7,226 results match your criteria Graefe's Archive for Clinical and Experimental Ophthalmology[Journal]


Efficacy of azithromycin 1.5% eyedrops vs oral doxycycline in meibomian gland dysfunction: a randomized trial.

Graefes Arch Clin Exp Ophthalmol 2019 Apr 22. Epub 2019 Apr 22.

Department of Ophthalmology, Faculty of Medicine, Chulalongkorn University and King Chulalongkorn Memorial Hospital, 1873 Rama 4 road, Bangkok, 10330, Thailand.

Purpose: To determine the efficacy of azithromycin 1.5% eyedrops compared with oral doxycycline in patients with moderate to severe meibomian gland dysfunction (MGD).

Methods: This prospective randomized trial included 169 participants with newly diagnosed moderate to severe MGD. Read More

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http://dx.doi.org/10.1007/s00417-019-04322-1DOI Listing

Comparison of the efficacy of different cell sources for transplantation in total limbal stem cell deficiency.

Graefes Arch Clin Exp Ophthalmol 2019 Apr 19. Epub 2019 Apr 19.

State Key Laboratory Cultivation Base, Shandong Provincial Key Laboratory of Ophthalmology, Shandong Eye Institute, Shandong Academy of Medical Sciences, 5 Yanerdao Road, Qingdao, 266071, China.

Purpose: The purpose of this study was to compare the efficacy of allogeneic cultured limbal epithelial transplantation (ACLET) and cultivated oral mucosal epithelial transplantation (COMET) in treating total limbal stem cell deficiency (LSCD).

Methods: In this retrospective cohort study, 73 patients (76 eyes) with total LSCD, including 41 patients (42 eyes) treated with ACLET and 32 patients (34 eyes) receiving COMET, were evaluated. The age, gender and injury cause of all patients were recorded. Read More

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http://dx.doi.org/10.1007/s00417-019-04316-zDOI Listing

Characterization of deeply embedded corneal foreign bodies with anterior segment optical coherence tomography.

Graefes Arch Clin Exp Ophthalmol 2019 Apr 18. Epub 2019 Apr 18.

Department of Ophthalmology, Meir Medical Center, Kfar Saba, Israel.

Purpose: The purpose of the study was to describe findings demonstrated by anterior segment spectral domain optical coherence tomography (AS-OCT) in various types of deeply embedded corneal foreign bodies.

Methods: In this experimental study, an ex vivo model of calf eyes was used and seven different foreign bodies were deeply embedded in the cornea, consisting of five different materials: glass, plastic, metal, wood, and pencil graphite. The eyes were photographed and then scanned by AS-OCT. Read More

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http://dx.doi.org/10.1007/s00417-019-04309-yDOI Listing

Correlation of retinal vascular perfusion density with dark adaptation in diabetic retinopathy.

Graefes Arch Clin Exp Ophthalmol 2019 Apr 17. Epub 2019 Apr 17.

Department of Ophthalmology, National Taiwan University Hospital, No. 7, Chun-Shan S. Rd., Taipei City, 100, Taiwan.

Purpose: To evaluate the anatomic versus functional changes in diabetic retinopathy (DR) by studying the correlation of retinal vascular perfusion density and dark adaptation (DA).

Methods: Optical coherence tomography angiography (OCTA) and DA tests were performed in diabetic patients and nondiabetic controls. DA was measured using AdaptDx dark adaptometer and the rod intercept was recorded. Read More

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http://link.springer.com/10.1007/s00417-019-04321-2
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http://dx.doi.org/10.1007/s00417-019-04321-2DOI Listing
April 2019
1 Read

Implementations of 3D printing in ophthalmology.

Graefes Arch Clin Exp Ophthalmol 2019 Apr 16. Epub 2019 Apr 16.

Department of Ophthalmology, Rambam Health Care Campus, 9602, 31096, Haifa, Israel.

Purpose: The purpose of this paper is to provide an in-depth understanding of how to best utilize 3D printing in medicine, and more particularly in ophthalmology in order to enhance the clinicians' ability to provide out-of-the-box solutions for unusual challenges that require patient personalization. In this review, we discuss the main applications of 3D printing for diseases of the anterior and posterior segments of the eye and discuss their current status and implementation. We aim to raise awareness among ophthalmologists and report current and future developments. Read More

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http://link.springer.com/10.1007/s00417-019-04312-3
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http://dx.doi.org/10.1007/s00417-019-04312-3DOI Listing
April 2019
1 Read

Age-related course of visual acuity obtained with ETDRS 2000 charts in persons with healthy eyes.

Graefes Arch Clin Exp Ophthalmol 2019 Apr 15. Epub 2019 Apr 15.

Department of Development Studies, Sensengasse 3, 1090, Vienna, Austria.

Purpose: To investigate the age-related course of best-corrected visual acuity in healthy eyes.

Methods: Two hundred participants (400 eyes) 25 to 74 years of age (114 females, 86 males) were investigated, 20 per 5-year age group. Best-corrected visual acuity was measured monocularly with the ETDRS 2000 charts at a distance of 4 m (Precision Vision, Woodstock, IL, USA). Read More

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http://dx.doi.org/10.1007/s00417-019-04320-3DOI Listing

Disinhibition of intrinsic photosensitive retinal ganglion cells in patients with X-linked congenital stationary night blindness.

Graefes Arch Clin Exp Ophthalmol 2019 Apr 13. Epub 2019 Apr 13.

Department of Ophthalmology, Klinikum Stuttgart, Kriegsbergstr. 60, 70174, Stuttgart, Germany.

Purpose: To assess the pupil light response (PLR) to chromatic stimulation in patients with different types of X-linked congenital stationary night blindness (CSNB).

Methods: Eight patients with CSNB due to CACNA1F and NYX mutations were exposed to blue and red light stimuli, and PLR was evaluated using infrared video pupillography. Pupil responses were compared between CSNB patients and healthy subjects (n = 34) at baseline, at maximum of constriction, for post-illumination pupil responses (PIPR) and the slope of redilation using Cohen's d. Read More

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http://dx.doi.org/10.1007/s00417-019-04319-wDOI Listing

A novel strategy for quantification of panoramic en face optical coherence tomography angiography scan field.

Graefes Arch Clin Exp Ophthalmol 2019 Apr 10. Epub 2019 Apr 10.

Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan.

Purpose: To compare the retinal area measured on a panoramic en face optical coherence tomography angiography (OCTA) image with that on an ultra-widefield fluorescein angiography (UWF FA) image.

Methods: Sixteen eyes (11 with branch retinal vein occlusion, 2 with central retinal vein occlusion, 1 with branch retinal artery occlusion, and 2 with hypertensive retinopathy) were included in this study. A panoramic en face OCTA image was created from five single non-panoramic en face OCTA 12 × 12-mm images. Read More

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http://dx.doi.org/10.1007/s00417-019-04310-5DOI Listing

Diffractive trifocal pseudophakic intraocular lenses in high myopic eyes: 2-year assessment after implantation.

Graefes Arch Clin Exp Ophthalmol 2019 Apr 9. Epub 2019 Apr 9.

Department of Refractive Surgery, Clínica Baviera Castellón, Castellón, Spain.

Purpose: To assess the visual outcomes and ocular safety when implanting diffractive trifocal intraocular lenses in a population of high myopic eyes.

Methods: This is a retrospective cumulative clinical study. Two hundred five myopic eyes consecutively operated in the hospitals of Clínica Baviera, Spain, were included. Read More

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http://dx.doi.org/10.1007/s00417-019-04302-5DOI Listing
April 2019
2 Reads

Outflow facility and extent of angle closure in a porcine model.

Graefes Arch Clin Exp Ophthalmol 2019 Apr 3. Epub 2019 Apr 3.

Department of Ophthalmology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.

Purpose: To establish the extent of anterior chamber angle circumference needed to maintain a physiological outflow facility (C). This could create a model to investigate focal outflow regulation.

Methods: Twenty anterior segments of porcine eyes were assigned to five groups, each with a different degree of cyanoacrylate-mediated angle closure: 90° (n = 4), 180° (n = 4), 270° (n = 4), 360° (n = 4), and four unoccluded control eyes. Read More

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http://dx.doi.org/10.1007/s00417-019-04279-1DOI Listing
April 2019
2 Reads

Eye Movement Perimetry and Frequency Doubling Perimetry: clinical performance and patient preference during glaucoma screening.

Graefes Arch Clin Exp Ophthalmol 2019 Apr 3. Epub 2019 Apr 3.

Medical and Vision Research Foundation, Chennai, India.

Purpose: To evaluate the screening accuracy of an Eye Movement Perimetry (EMP) in comparison with Frequency Doubling Perimetry (FDP) and to investigate the patient preference and perception towards these visual field screening methods.

Methods: A total of 104 healthy subjects (mean age (SD) of 48 (14) years) and 73 glaucoma patients (mean age (SD) of 52 (13) years) were recruited. All the participants underwent a comprehensive ophthalmic evaluation including the 24-2 SITA standard protocol on the Humphrey Field Analyzer (HFA). Read More

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http://dx.doi.org/10.1007/s00417-019-04311-4DOI Listing
April 2019
3 Reads
1.908 Impact Factor

Ocular surface system alterations in ocular graft-versus-host disease: all the pieces of the complex puzzle.

Graefes Arch Clin Exp Ophthalmol 2019 Apr 3. Epub 2019 Apr 3.

Ophthalmology Unit, St. Orsola-Malpighi University Hospital, University of Bologna, Via Palagi 9, 40138, Bologna, Italy.

Purpose: Graft-versus-host disease (GVHD) is a major complication of allogeneic hematopoietic stem cells transplantation, occurring in about half of transplanted patients. This condition seems to be the result of a progressive immune-mediated damage that can involve various tissues, including the eyes. The ocular surface system is the ocular structure most frequently impaired, and dry eye disease is considered the hallmark of ocular GVHD. Read More

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http://link.springer.com/10.1007/s00417-019-04301-6
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http://dx.doi.org/10.1007/s00417-019-04301-6DOI Listing
April 2019
3 Reads

Video recording and light intensity change analysis during cataract surgery using an animal model.

Graefes Arch Clin Exp Ophthalmol 2019 Apr 3. Epub 2019 Apr 3.

Department of Ophthalmology, Shiley Eye Institute, University of California, La Jolla, San Diego, USA, 9415 Campus Point Dr #0946, La Jolla, San Diego, CA, 92093-0946, USA.

Purpose: To estimate light exposure changes during cataract surgery through intraoperative images simulated from the "patient's perspective" using an animal model.

Methods: In this experimental study, a 3-mm maculostomy was performed through the posterior globe's surface of 15 porcine eyes. Eyes were fixated to a glass slide and placed over an iPad camera. Read More

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http://link.springer.com/10.1007/s00417-019-04288-0
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http://dx.doi.org/10.1007/s00417-019-04288-0DOI Listing
April 2019
3 Reads

Optimizing esthetic outcomes in graded full-thickness anterior blepharotomy for Graves' ophthalmopathy.

Graefes Arch Clin Exp Ophthalmol 2019 Apr 2. Epub 2019 Apr 2.

Department of Ophthalmology, National Taiwan University Hospital, Taipei, Taiwan.

Purpose: Current outcome measures do not adequately address the esthetic aspect of the surgical outcome of anterior blepharotomy for Graves' ophthalmopathy. This study aims to highlight the role of tarsal platform show (TPS) in optimizing the esthetic outcome of graded full-thickness anterior blepharotomy for dysthyroid upper eyelid retraction in an ethnic Chinese population.

Methods: The records of patients with Graves' ophthalmopathy who underwent anterior blepharotomy for upper eyelid retraction over a period of 30 months were retrospectively reviewed. Read More

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http://dx.doi.org/10.1007/s00417-019-04308-zDOI Listing
April 2019
2 Reads

Serum and aqueous humor vitamin D levels in patients with diabetic macular edema.

Graefes Arch Clin Exp Ophthalmol 2019 Apr 1. Epub 2019 Apr 1.

Department of Ophthalmology, Kangdong Sacred Heart Hospital, Hallym University College of Medicine, #150 Seongan-ro, Seoul, Gangdong-gu, 05355, South Korea.

Purpose: To compare serum and aqueous humor (AH) vitamin D levels between the patients with diabetic macular edema (DME) and controls.

Methods: A total of 65 subjects (30 DME, 35 control) were included. One-third of the control group had hypertension, dyslipidemia, or diabetes mellitus without diabetic retinopathy as underlying diseases. Read More

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http://dx.doi.org/10.1007/s00417-019-04305-2DOI Listing

Early detection of cone photoreceptor cell loss in retinitis pigmentosa using adaptive optics scanning laser ophthalmoscopy.

Graefes Arch Clin Exp Ophthalmol 2019 Apr 1. Epub 2019 Apr 1.

Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Maidashi 3-1-1, Higashi-ku, Fukuoka, 812-8582, Japan.

Purpose: The purpose of the study was to investigate the characteristics of the parafoveal cone density changes in patients with retinitis pigmentosa (RP) using adaptive optics scanning laser ophthalmoscopy (AO-SLO).

Methods: A total of 14 eyes of RP patients and 10 eyes of control subjects were examined. High-resolution images of cone photoreceptor cells were obtained with a Canon AO-SLO system in the four retinal regions of the superior, inferior, temporal, and nasal areas located 1. Read More

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http://dx.doi.org/10.1007/s00417-019-04307-0DOI Listing
April 2019
2 Reads

Long-term incidence and timing of reactivation in patients with type 3 neovascularization after initial treatment.

Graefes Arch Clin Exp Ophthalmol 2019 Apr 1. Epub 2019 Apr 1.

Department of Ophthalmology, Kim's Eye Hospital, Konyang University College of Medicine, #156 Youngdeungpo-dong 4ga, Youngdeungpo-gu, Seoul, 150-034, South Korea.

Purpose: The purpose of the present study was to evaluate the long-term incidence and timing of reactivation in patients with type 3 neovascularization who were treated with three monthly anti-vascular endothelial growth factor (VEGF) injections.

Methods: A total of 179 patients (179 eyes) diagnosed with type 3 neovascularization with dry macula after three monthly anti-VEGF loading injections were included in this retrospective study. After the initial treatment, patients were followed up without further injection until the first reactivation. Read More

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http://dx.doi.org/10.1007/s00417-019-04306-1DOI Listing
April 2019
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Comparison of Spectralis and Cirrus spectral domain optical coherence tomography for the objective morphometric assessment of the neuroretinal rim width.

Graefes Arch Clin Exp Ophthalmol 2019 Mar 29. Epub 2019 Mar 29.

Department of Ophthalmology and Optometry, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria.

Purpose: The assessment of cup-disc ratio as a surrogate parameter for the neuroretinal rim width (NRW) of the optic nerve is well established, but prone to human error and imprecision. Objective assessment of the NRW is provided by spectral domain optical coherence tomography (SD-OCT). This study is the first to systematically compare NRW measurements acquired with the Carl Zeiss Meditech Cirrus HD-OCT 5000 and the Heidelberg Engineering Spectralis SD-OCT. Read More

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http://dx.doi.org/10.1007/s00417-019-04299-xDOI Listing
March 2019
2 Reads

Impact of pigment dispersion on trabecular meshwork cells.

Graefes Arch Clin Exp Ophthalmol 2019 Mar 28. Epub 2019 Mar 28.

Department of Ophthalmology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.

Purpose: Dysfunction of the trabecular meshwork (TM) in pigmentary glaucoma contributes to increased aqueous humor outflow resistance and intraocular pressure. In this study, we investigated the effect of pigment dispersion on trabecular meshwork cells.

Methods: Porcine TM cells from ab interno trabeculectomy specimens were exposed to pigment dispersion, then, analyzed for changes in morphology, immunostaining, and ultrastructure. Read More

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http://dx.doi.org/10.1007/s00417-019-04300-7DOI Listing
March 2019
1.908 Impact Factor

Folic acid deficiency and vision: a review.

Authors:
Ouafa Sijilmassi

Graefes Arch Clin Exp Ophthalmol 2019 Mar 27. Epub 2019 Mar 27.

Faculty of Optics and Optometry, Department of Anatomy and Human Embryology, Universidad Complutense de Madrid, Avda. Arcos de Jalón, 118, 28037, Madrid, Spain.

Folic acid (FA), also termed folate, is an essential vitamin for health at all ages since it participates in the biosynthesis of nucleotides, amino acids, neurotransmitters, and certain vitamins. It is therefore crucial for rapidly growing tissues such as those of the fetus. It is becoming clear that FA deficiency and impaired folate pathways are implicated in many diseases of both early life and old age. Read More

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http://dx.doi.org/10.1007/s00417-019-04304-3DOI Listing
March 2019
1 Read

Conservative management of suspicious melanocytic lesions of the iris.

Graefes Arch Clin Exp Ophthalmol 2019 Mar 27. Epub 2019 Mar 27.

Ocular Melanoma Center, Retina Service, Mass Eye and Ear, 243 Charles Street., Boston, MA, 02114, USA.

Purpose: The diagnosis of iris melanoma can be difficult, with no established diagnostic criteria currently available. Careful monitoring of patients with suspicious iris lesions is one approach to managing these tumors. We determined the risk of malignant transformation and melanoma-related mortality in patients under observation to evaluate the validity of this management approach. Read More

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http://dx.doi.org/10.1007/s00417-019-04296-0DOI Listing
March 2019
1 Read

Proton radiotherapy in advanced malignant melanoma of the conjunctiva.

Graefes Arch Clin Exp Ophthalmol 2019 Mar 27. Epub 2019 Mar 27.

Department of Radiation Therapy, University Hospital Essen, Hufelandstrasse 55, 45147, Essen, Germany.

Background: The management of conjunctival melanoma is challenging and frequently ends in exenteration. The aim of this retrospective study was to evaluate the long-term results of proton beam radiation with regard to various clinical parameters.

Methods: Eighty-nine patients with extended conjunctival melanoma (≥T2) and multifocal bulbar located tumors (T1c/d) were treated consecutively with proton radiotherapy (dose 45 Gy). Read More

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http://dx.doi.org/10.1007/s00417-019-04286-2DOI Listing
March 2019
1 Read

Retinopathy screening results of late-preterm infants born at 32-35 weeks of gestational age.

Graefes Arch Clin Exp Ophthalmol 2019 Mar 26. Epub 2019 Mar 26.

Department of Ophthalmology, Sisli Hamidiye Etfal Training and Research Hospital, University of Health Sciences, Halaskargazi Cad. Etfal St. 34371 Sisli, Istanbul, Turkey.

Purpose: The aim of this retrospective, nonrandomized, observational clinical study was to evaluate the screening results for retinopathy of prematurity (ROP) of late-preterm infants born at 32-35 weeks gestational age (GA).

Methods: Retinopathy screening data of late-preterm infants were evaluated between January 2015 and September 2018. The zones and stages of ROP development were classified according to the International ROP Committee criteria. Read More

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http://dx.doi.org/10.1007/s00417-019-04298-yDOI Listing

Growth curves of myopia-related parameters to clinically monitor the refractive development in Chinese schoolchildren.

Graefes Arch Clin Exp Ophthalmol 2019 May 23;257(5):1045-1053. Epub 2019 Mar 23.

Carl Zeiss Vision International GmbH, Technology and Innovation, Turnstraße 27, 73430, Aalen, Germany.

Purpose: To produce a clinical model for the prediction of myopia development based on the creation of percentile curves of axial length in school-aged children from Wuhan in central China.

Methods: Data of 12,554 children (6054 girls and 6500 boys) were collected and analyzed for the generation of the axial length growth curves. A second data set with 226 children and three yearly successive measurements was used to verify the predictive power of the axial length growth percentile curves. Read More

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http://dx.doi.org/10.1007/s00417-019-04290-6DOI Listing

Müller cells and choriocapillaris in the pathogenesis of geographic atrophy secondary to age-related macular degeneration.

Graefes Arch Clin Exp Ophthalmol 2019 Mar 23. Epub 2019 Mar 23.

IRCCS - Fondazione Bietti, Rome, Italy.

Purpose: To better understand the pathophysiology of geographic atrophy (GA), secondary to age-related macular degeneration, eyes affected by unilateral GA (and CNV in the fellow eye; U-GA group) or by bilateral GA (B-GA group) were evaluated using an integrated morpho-functional approach and quantifying biomarker of retinal macroglial activity.

Methods: Patients with U-GA and B-GA and foveal-sparing were consecutively enrolled in a prospective study. All included eyes underwent fundus photography, fundus autofluorescence (FAF), foveal retinal and choroidal thicknesses (RT, CT), contrast sensitivity, best-corrected visual acuity (BCVA), low-luminance VA (LLVA) and low-luminance deficit (LLD), and mesopic and scotopic microperimetry and multifocal electroretinography (mfERG). Read More

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http://dx.doi.org/10.1007/s00417-019-04289-zDOI Listing

The absence of fundus abnormalities in Stargardt disease.

Graefes Arch Clin Exp Ophthalmol 2019 Mar 22. Epub 2019 Mar 22.

Department of Ophthalmology (400), Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, P.O. Box 9101, 6500 HB, Nijmegen, The Netherlands.

Purpose: To raise awareness of Stargardt disease (STGD1) patients without fundus abnormalities.

Methods: Medical records were evaluated for age at onset, initial symptoms and diagnosis, reason for delay of diagnosis, age at STGD1 diagnosis, best-corrected visual acuity (BCVA), ophthalmoscopy, fundus photography, fundus autofluorescence (FAF), fluorescein angiography (FA), spectral-domain optical coherence tomography (SD-OCT), full-field electroretinography (ffERG), color vision test, and the presence of ABCA4 variants.

Results: In 11. Read More

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http://link.springer.com/10.1007/s00417-019-04280-8
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http://dx.doi.org/10.1007/s00417-019-04280-8DOI Listing
March 2019
1 Read

Aggressive Posterior Retinopathy of Prematurity Treated with Intravitreal Bevacizumab: Late Period Fluorescein Angiographic Findings.

Graefes Arch Clin Exp Ophthalmol 2019 Mar 20. Epub 2019 Mar 20.

Izmir S.B.U. Dr. Behcet Uz Child Diseases and Surgery Research and Training Hospital, Izmir, Turkey.

Objective: To evaluate vascularization end limit of the peripheral retina and describe vascular development patterns of patients at the late period with aggressive posterior retinopathy of prematurity (APROP) who were treated with a single intravitreal injection of bevacizumab.

Methods: All patients were examined with RetCam III and fluorescein angiography (FA) within 90-100 gestational week. The vascularization end limit according to the zones and vascular structural abnormalities were noted. Read More

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http://dx.doi.org/10.1007/s00417-019-04292-4DOI Listing
March 2019
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Sickle cell retinopathy. A focused review.

Graefes Arch Clin Exp Ophthalmol 2019 Mar 20. Epub 2019 Mar 20.

Vitreoretinal Division, King Khaled Eye Specialist Hospital, Al-Oruba Street, 7191, Riyadh, 11462, Kingdom of Saudi Arabia.

Purpose: To provide a focused review of sickle cell retinopathy in the light of recent advances in the pathogenesis, multimodal retinal imaging, management of the condition, and migration trends, which may lead to increased prevalence of the condition in the Western world.

Methods: Non-systematic focused literature review.

Results: Sickle retinopathy results from aggregation of abnormal hemoglobin in the red blood cells in the retinal microcirculation, leading to reduced deformability of the red blood cells, stagnant blood flow in the retinal precapillary arterioles, thrombosis, and ischemia. Read More

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http://dx.doi.org/10.1007/s00417-019-04294-2DOI Listing
March 2019
2 Reads

Relationship between choroidal structure and duration of diabetes.

Graefes Arch Clin Exp Ophthalmol 2019 Mar 18. Epub 2019 Mar 18.

Department of Ophthalmology, Teine Keijinkai Hospital, Sapporo, Japan.

Background: The aim of this study was to evaluate the relationship between the choroidal structure of diabetic patients without diabetic retinopathy (DR) and duration of diabetes.

Methods: This study is a retrospective observational study in diabetic patients without DR. Eyes with diabetes mellitus (DM) (n = 105) were divided into two groups based on the duration: long duration group (over 10 years, n = 31) and short duration group (less than 10 years, n = 74). Read More

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http://dx.doi.org/10.1007/s00417-019-04295-1DOI Listing
March 2019
2 Reads

Idiopathic retinal vasculitis, aneurysms and neuroretinitis (IRVAN): case series of three patients with multimodal imaging.

Graefes Arch Clin Exp Ophthalmol 2019 May 15;257(5):1013-1018. Epub 2019 Mar 15.

Addenbrookes Hospital, Cambridge University Hospitals NHS Trust, Hills Road, Cambridge, CB2 0QQ, UK.

Purpose: The purpose of this study was to report the clinical presentation, disease progression, treatment and complications of IRVAN.

Method: Case series PATIENTS: Six eyes from three patients were included.

Results: All eyes were treated with pan-retinal photocoagulation (PRP). Read More

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http://link.springer.com/10.1007/s00417-019-04291-5
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http://dx.doi.org/10.1007/s00417-019-04291-5DOI Listing
May 2019
8 Reads

Risk factors for failure of vitrectomy cell block technique in cytological diagnosis of vitreoretinal lymphoma.

Graefes Arch Clin Exp Ophthalmol 2019 May 13;257(5):1029-1036. Epub 2019 Mar 13.

Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

Purpose: To determine the factors that may affect the accuracy of vitrectomy cell block technique in detecting atypical lymphoid cells in patients with vitreoretinal lymphoma (VRL).

Methods: We retrospectively reviewed 43 eyes in 39 patients who underwent vitrectomy for definitive histological diagnosis of VRL with vitrectomy cell block technique and/or smear preparation at Kyushu University Hospital from January 2001 to March 2016. The association of detection of atypical lymphoid cells using vitrectomy cell block technique with the following factors was assessed using logistic regression analysis: age at diagnosis, sex, presence or absence of concurrent cataract surgery with vitrectomy, clinical grading of vitreous haze, presence or absence of subretinal tumor infiltration, interval between initial symptoms and vitrectomy, and presence or absence of systemic corticosteroid therapy before vitrectomy. Read More

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http://dx.doi.org/10.1007/s00417-019-04266-6DOI Listing
May 2019
3 Reads

Long-term surgical outcomes of patients with consecutive exotropia.

Graefes Arch Clin Exp Ophthalmol 2019 May 13;257(5):1037-1044. Epub 2019 Mar 13.

Department of Ophthalmology, Seoul National University College of Medicine, 101 Daehak-Ro, Jongno-Gu, Seoul, 110-744, South Korea.

Purpose: To evaluate the long-term surgical outcome of patients with consecutive exotropia.

Methods: Patients who underwent surgery for the treatment of consecutive exotropia between January 2008 and July 2016 with a minimum follow-up period of 2 years were retrospectively reviewed. Surgical outcomes were classified based on postoperative angle of deviation at 2 years as follows: success (esodeviation ≤ 5 prism diopters [PD] to exodeviation ≤ 10 PD), and recurrence [exodeviation > 10 PD]). Read More

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http://link.springer.com/10.1007/s00417-019-04293-3
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http://dx.doi.org/10.1007/s00417-019-04293-3DOI Listing
May 2019
4 Reads

Dermatologic tacrolimus ointment on the eyelids for steroid-refractory vernal keratoconjunctivitis.

Graefes Arch Clin Exp Ophthalmol 2019 May 9;257(5):967-974. Epub 2019 Mar 9.

Department of Ophthalmology, National Taiwan University Hospital, No.7, Chung-Shan South Road, Taipei, Taiwan.

Purpose: The study aims to evaluate the therapeutic effects of dermatologic tacrolimus ointment on eyelids to treat refractory vernal keratoconjunctivitis (VKC).

Method: This institutional study examined the effects of steroid treatment for 10 patients diagnosed with severe VKC refractory to steroid treatment. Patients received 0. Read More

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http://dx.doi.org/10.1007/s00417-019-04287-1DOI Listing
May 2019
1 Read

Clinical characteristics of pachydrusen in central serous chorioretinopathy.

Graefes Arch Clin Exp Ophthalmol 2019 Mar 9. Epub 2019 Mar 9.

Department of Ophthalmology, Gunma University, School of Medicine, 3-39-15 Showa-machi, Maebashi, Gunma, 371-8511, Japan.

Purpose: To evaluate the clinical characteristics of pachydrusen in central serous chorioretinopathy (CSC) and investigate the relationship between choroidal circulation and pachydrusen.

Methods: In a retrospective case series of 302 eyes of 151 patients with treatment-naïve CSC, we assessed the incidence of pachydrusen and their features on indocyanine green angiography (ICGA) and optical coherence tomography (OCT).

Results: Pachydrusen were observed in 82 of the 302 eyes (27. Read More

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http://dx.doi.org/10.1007/s00417-019-04284-4DOI Listing

Rho kinase inhibitors-a review on the physiology and clinical use in Ophthalmology.

Graefes Arch Clin Exp Ophthalmol 2019 Mar 7. Epub 2019 Mar 7.

Ophthalmology Department, Centro Hospitalar Universitário Lisboa Central (CHULC), Alameda Santo António Capuchos, 1169-050, Lisbon, Portugal.

The Rho kinase (ROCK) signaling pathway is involved in several cellular events that include cell proliferation and cytoskeleton modulation leading to cell adhesion. The ROCK pathway in the human eye has been hypothesized to play important roles in corneal endothelial cell physiology and pathologic states. In addition, ROCK signaling has been identified as an important regulator of trabecular meshwork (TM) outflow, which is altered in glaucomatous eyes. Read More

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http://dx.doi.org/10.1007/s00417-019-04283-5DOI Listing
March 2019
1.908 Impact Factor

Endothelial cell density and corneal graft thickness following excimer laser vs. femtosecond laser-assisted penetrating keratoplasty-a prospective randomized study.

Graefes Arch Clin Exp Ophthalmol 2019 May 21;257(5):975-981. Epub 2019 Feb 21.

Department of Ophthalmology, Saarland University Medical Center, Kirrberger Str. 100, 66424, Homburg/Saar, Germany.

Purpose: The study aims to compare the impact of non-mechanical excimer laser-assisted (EXCIMER) and femtosecond laser-assisted (FEMTO) trephinations on graft endothelial cell density (ECD) and graft thickness before and after suture removal following penetrating keratoplasty (PK).

Methods: The inclusion criteria for this prospective, randomized, clinical study were as follows: (1) surgeries performed by one surgeon; (2) primary central PK; (3) keratoconus (KC) or Fuchs' dystrophy (FUCHS); (4) no previous intraocular surgery; (5) graft oversize, 0.1 mm; and (6) 16-bite double-running suture. Read More

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http://dx.doi.org/10.1007/s00417-019-04263-9DOI Listing

Correction to: Visual impairment and blindness in institutionalized elderly in Germany.

Graefes Arch Clin Exp Ophthalmol 2019 05;257(5):1057

Department of Ophthalmology, University of Bonn, Ernst-Abbe-Str. 2, D-53127, Bonn, Germany.

The original version of this article inadvertently contained a mistake. Authors incorrectly listed in PDF version while correctly presented in the html version. Read More

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http://dx.doi.org/10.1007/s00417-019-04277-3DOI Listing

Correction to: Heredity and in vivo confocal microscopy of punctiform and polychromatic pre-Descemet dystrophy.

Graefes Arch Clin Exp Ophthalmol 2019 05;257(5):1059

Department of Ophthalmology, La Paz University Hospital, idiPaz, Sor Ángela de la Cruz road, number 9, 7A door, 28020, Madrid, Spain.

In the original publication, presentation of the following author names are incorrect in the HTML version. Read More

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http://dx.doi.org/10.1007/s00417-019-04276-4DOI Listing

Evaluation of adenovirus amplified detection of immunochromatographic test using tears including conjunctival exudate in patients with adenoviral keratoconjunctivitis.

Graefes Arch Clin Exp Ophthalmol 2019 Apr 2;257(4):815-820. Epub 2019 Mar 2.

Department of Ophthalmology, Fukuoka University School of Medicine, 7-45-1 Nanakuma, Jonan-ku, Fukuoka, 814-0180, Japan.

Background: We evaluated a novel silver amplification immunochromatography test for rapid detection of adenovirus (AdV) antigen equipped with an automated reader system using tears including conjunctival exudate in patients with adenoviral keratoconjunctivitis.

Methods: Two kinds of immunochromatographic (IC) kits, a conventional IC kit for conjunctival scrapings (control kit) and an IC kit using tears including conjunctival exudate collected by pressing a filter paper strip on the conjunctiva (test kit), were tested on 90 patients who attended Migita Eye Clinic with suspected adenoviral conjunctivitis. The results of the test kits were automatically obtained by a specific reader, which was based on silver amplification immunochromatography system, in 15 min. Read More

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http://dx.doi.org/10.1007/s00417-019-04281-7DOI Listing

Enlargement of the foveal avascular zone detected by optical coherence tomography angiography in diabetic children without diabetic retinopathy.

Graefes Arch Clin Exp Ophthalmol 2019 Apr 1;257(4):689-697. Epub 2019 Mar 1.

Department of Ophthalmology, Chair of Ophthalmology and Optometry. Heliodor Swiecicki University Hospital, Poznan University of Medical Sciences, 16/18 Grunwaldzka Street, 60-780, Poznan, Poland.

Purpose: Evaluation of foveal avascular zone (FAZ) in children with diabetes (DM) using OCTA.

Methods: We examined 112 diabetic children without DR aged 6-18 years and 30 age-matched controls using Topcon OCT Angiography and measured FAZ in superficial (SCP) and deep capillary plexus (DCP). The study group was divided into three subgroups depending on DM duration group 1: < 5 years (n = 40), group 2: 5-10 years (n = 42), group 3: > 10 years (n = 30). Read More

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http://dx.doi.org/10.1007/s00417-019-04264-8DOI Listing

Methods for evaluating quality of life and vision in patients undergoing lens refractive surgery.

Graefes Arch Clin Exp Ophthalmol 2019 Mar 1. Epub 2019 Mar 1.

Spektrum Eye Clinic, Wroclaw, Poland.

Purpose: Cataract surgery has evolved into a procedure that generally yields the best postoperative refractive result attainable. Patients with multifocal intraocular lenses (IOLs) present higher rates of spectacle independence, although reduced intermediate vision, dysphotopsias, and a loss of image quality might also be experienced. The aim of the study was to review the methods for assessing quality of life and vision in patients undergoing lens refractive surgery in randomized controlled trials. Read More

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http://link.springer.com/10.1007/s00417-019-04270-w
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http://dx.doi.org/10.1007/s00417-019-04270-wDOI Listing
March 2019
5 Reads

Additional thought concerning the glaucomas and systemic disease.

Authors:
Ian Murdoch

Graefes Arch Clin Exp Ophthalmol 2019 04 28;257(4):675-676. Epub 2019 Feb 28.

Institute of Ophthalmology, University College London, Bath Street EC1V 9EL, London, UK.

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http://dx.doi.org/10.1007/s00417-019-04282-6DOI Listing

Durability of every-8-week aflibercept maintenance therapy in treatment-experienced neovascular age-related macular degeneration.

Graefes Arch Clin Exp Ophthalmol 2019 Apr 26;257(4):741-748. Epub 2019 Feb 26.

Department of Ophthalmology, Jacobs Retina Center at the Shiley Eye Institute, University of California San Diego, 9415 Campus Point Drive, La Jolla, CA, 92037, USA.

Purpose: To determine the proportion of treatment-experienced eyes with exudative age-related macular degeneration successfully treated with every-4-week aflibercept that can be kept dry on fixed every-8-week aflibercept injections (maintenance).

Methods: In this retrospective chart review, we evaluated our cohort of patients treated with a treatment paradigm for CNV in AMD. Initially, patients were treated with bevacizumab or ranibizumab and switched to every-4-week aflibercept when therapeutic responses were not durable or were suboptimal. Read More

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http://dx.doi.org/10.1007/s00417-018-04232-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441364PMC
April 2019
2 Reads

Peripapillary and macular morpho-vascular changes in patients with genetic or clinical diagnosis of autosomal dominant optic atrophy: a case-control study.

Graefes Arch Clin Exp Ophthalmol 2019 May 24;257(5):1019-1027. Epub 2019 Feb 24.

Department of Ophthalmology, Centro Hospitalar e Universitário de Coimbra (CHUC), Praceta Prof. Mota Pinto, 3049, Coimbra, Portugal.

Purpose: To evaluate the macular and peripapillary morpho-vascular changes in ADOA, using optical coherence tomography (OCT) and OCT angiography (OCTA).

Methods: Prospectively defined, cross-sectional case-control study. Consecutive patients with a genetic or clinical diagnosis of ADOA along with age- and sex-matched controls were included. Read More

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http://dx.doi.org/10.1007/s00417-019-04267-5DOI Listing

Macular perfusion changes assessed with optical coherence tomography angiography after vitrectomy for rhegmatogenous retinal detachment.

Graefes Arch Clin Exp Ophthalmol 2019 Apr 22;257(4):733-740. Epub 2019 Feb 22.

Department of Ophthalmology, Shanghai General Hospital (Shanghai First People's Hospital), School of Medicine, Shanghai Jiao Tong University, 100 Hai Ning Road, Shanghai, 200080, China.

Purpose: To explore macular perfusion changes in patients with rhegmatogenous retinal detachment (RRD) involved the macula following successful surgery and to evaluate the correlation between macular blood flow density and visual outcomes using optical coherence tomography angiography (OCTA).

Methods: This retrospective study included 14 eyes (14 patients) with macular-off RRD that underwent a standard three-port 23-gauge pars plana vitrectomy (PPV) and intraocular gas tamponade combined with phacoemulsification, aspiration, and intraocular lens implantation. OCTA was used to evaluate the macular perfusion changes throughout postoperative 12 weeks in the superficial capillary plexus (SCP), deep capillary plexus (DCP), and choriocapillary plexus (CCP). Read More

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http://dx.doi.org/10.1007/s00417-019-04273-7DOI Listing
April 2019
3 Reads

Epiblepharon correction in Korean children based on the epicanthal pathology.

Graefes Arch Clin Exp Ophthalmol 2019 Apr 22;257(4):821-826. Epub 2019 Feb 22.

Department of Ophthalmology, CHA Bundang Medical Center, #59 Yatap-ro, Bundang-gu, Seongnam, 13496, Republic of Korea.

Purpose: This study aims to investigate the surgical outcomes of a novel epiblepharon correction method based on the pathologic features of epicanthal tissue. The correlation between the pathology and clinical presentations was also studied.

Methods: This retrospective study included 72 eyelids of 36 children with epiblepharon and epicanthal folds. Read More

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http://dx.doi.org/10.1007/s00417-019-04271-9DOI Listing

Three-dimensional pattern of extraretinal neovascular development in retinopathy of prematurity.

Graefes Arch Clin Exp Ophthalmol 2019 Apr 21;257(4):677-688. Epub 2019 Feb 21.

Department of Ophthalmology, Duke University School of Medicine, 2351 Erwin Road-Suite 1002 AERI, Durham, NC, 27710, USA.

Background: The application of three-dimensional (3D) visualization techniques to evaluate the earliest visible onset of abnormal retinal vascular development in preterm infants with retinopathy of prematurity (ROP), using bedside non-contact optical coherence tomography (OCT) imaging to characterize morphology and sequential structural changes of abnormal extraretinal neovascularization.

Methods: Thirty-one preterm infants undergoing routine ROP screening with written informed consent for research imaging were enrolled in this prospective observational study. We imaged the macula and temporal periphery of preterm infants using a handheld OCT system (Envisu 2300 or handheld swept-source research system). Read More

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http://dx.doi.org/10.1007/s00417-019-04274-6DOI Listing

Re: Baumgarten et al.: Vitrectomy with and without encircling band for pseudophakic retinal detachment with inferior breaks: VIPER Study Report No. 3. Graefes Arch Clin Exp Ophthalmol. 2018 Nov;256(11):2069-2073. doi: 10.1007/s00417-018-4106-6. Epub 2018 Aug 23.

Graefes Arch Clin Exp Ophthalmol 2019 04 20;257(4):843. Epub 2019 Feb 20.

Department of Ophthalmology, Addenbrooke's Hospital, Cambridge University Hospitals NHS Foundation Trust, Cambridge Biomedical Campus, Hills Road, Cambridge, CB2 0QQ, UK.

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http://dx.doi.org/10.1007/s00417-019-04268-4DOI Listing
April 2019
3 Reads

Investigating retinal toxicity of a lutein-based dye in a model of isolated and perfused bovine retina.

Graefes Arch Clin Exp Ophthalmol 2019 May 20;257(5):961-966. Epub 2019 Feb 20.

Center for Ophthalmology, University of Tuebingen, Elfriede-Aulhorn-Straße 7, 72076, Tuebingen, Germany.

Purpose: Retidyne™ is a new lutein-based dye for internal limiting membrane staining. It uses the intrinsic staining characteristics of lutein which is already known to act as an antioxidant and blue-light filter in the human retina. We investigated retinal tolerance to different staining times measured by the electroretinogram (ERG) of an isolated and perfused retina whole mount. Read More

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http://dx.doi.org/10.1007/s00417-019-04260-yDOI Listing

Optical coherence tomography analysis of filtering blebs after long-term, functioning trabeculectomy and XEN® stent implant.

Graefes Arch Clin Exp Ophthalmol 2019 May 20;257(5):1005-1011. Epub 2019 Feb 20.

Department of Ophthalmology, Hospital Universitario Príncipe de Asturias, Carretera Alcalá-Meco s/n, Alcalá de Henares, 28805, Madrid, Spain.

Purpose: The purpose of this study was to use Triton® SweptSource OCT to evaluate the morphology of blebs formed when eyes are treated with XEN® implants and to compare these with the blebs in successfully functioning eyes after trabeculectomy (TB) and with eyes of healthy controls.

Methods: A cross-sectional, observational study. We analyzed 25 eyes, 15 after TB and 10 with XEN® implants, comparing them with 23 healthy eyes (controls). Read More

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http://dx.doi.org/10.1007/s00417-019-04272-8DOI Listing