7,177 results match your criteria Graefe's Archive for Clinical and Experimental Ophthalmology[Journal]


Optical coherence tomography analysis of filtering blebs after long-term, functioning trabeculectomy and XEN® stent implant.

Graefes Arch Clin Exp Ophthalmol 2019 Feb 20. Epub 2019 Feb 20.

Department of Ophthalmology, Hospital Universitario Príncipe de Asturias, Carretera Alcalá-Meco s/n, Alcalá de Henares, 28805, Madrid, Spain.

Purpose: The purpose of this study was to use Triton® SweptSource OCT to evaluate the morphology of blebs formed when eyes are treated with XEN® implants and to compare these with the blebs in successfully functioning eyes after trabeculectomy (TB) and with eyes of healthy controls.

Methods: A cross-sectional, observational study. We analyzed 25 eyes, 15 after TB and 10 with XEN® implants, comparing them with 23 healthy eyes (controls). Read More

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http://dx.doi.org/10.1007/s00417-019-04272-8DOI Listing
February 2019

Choroidal neovascularization imaging using multiple en face optical coherence tomography angiography image averaging.

Graefes Arch Clin Exp Ophthalmol 2019 Feb 19. Epub 2019 Feb 19.

Department of Ophthalmology, Tokyo Women's Medical University, 8-1 Kawadacho, Shinjuku-ku, Tokyo, 162-8666, Japan.

Purpose: To determine the effects of averaging five en face optical coherence tomography angiographic (OCTA) images on the quality of the images in eyes with a choroidal neovascularization (CNV).

Methods: Twenty-seven eyes of 25 patients (18 men, 7 women; average age 71.0 years) with a CNV were examined by OCTA (OCT HS-100, Canon. Read More

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http://dx.doi.org/10.1007/s00417-019-04275-5DOI Listing
February 2019

Impact of antibiotic resistance of pathogens and early vitrectomy on the prognosis of infectious endophthalmitis: a 10-year retrospective study.

Graefes Arch Clin Exp Ophthalmol 2019 Feb 13. Epub 2019 Feb 13.

Department of Ophthalmology, Gangnam Severance Hospital, Yonsei University College of Medicine, 211, Eonjuro, Gangnam-gu, Seoul, 135-720, South Korea.

Purpose: Infectious endophthalmitis (IE) is a severe complication that can lead to blindness even with treatment. However, the impact of antibiotic resistance and early vitrectomy on its prognosis has scarcely been documented. This study investigated the impact of antibiotic resistance of pathogen and early vitrectomy on the prognosis of IE. Read More

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http://dx.doi.org/10.1007/s00417-019-04261-xDOI Listing
February 2019

Two-year results of a multicenter study of the ab interno gelatin implant in medically uncontrolled primary open-angle glaucoma.

Graefes Arch Clin Exp Ophthalmol 2019 Feb 13. Epub 2019 Feb 13.

Department of Ophthalmology, University Hospitals UZ Leuven, Leuven, Belgium.

Purpose: To evaluate the effectiveness of an ab interno subconjunctival gelatin implant as primary surgical intervention in reducing intraocular pressure (IOP) and IOP-lowering medication count in medically uncontrolled moderate primary open-angle glaucoma (POAG).

Methods: In this prospective, non-randomized, open-label, multicenter, 2-year study, eyes with medicated baseline IOP 18-33 mmHg on 1-4 topical medications were implanted with (phaco + implant) or without (implant alone) phacoemulsification. Changes in mean IOP and medication count at months 12 (primary outcomes) and 24, clinical success rate (eyes [%] achieving ≥ 20% IOP reduction from baseline on the same or fewer medications without glaucoma-related secondary surgical intervention), intraoperative complications, and postoperative adverse events were assessed. Read More

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http://dx.doi.org/10.1007/s00417-019-04251-zDOI Listing
February 2019

Long-term follow-up of intraocular pressure and pressure-lowering medication in patients after ab-interno trabeculectomy with the Trabectome.

Graefes Arch Clin Exp Ophthalmol 2019 Feb 9. Epub 2019 Feb 9.

Eye Center, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany.

Background: The minimally invasive ab-interno trabeculectomy (AIT) via electro-ablation with the Trabectome has been on the European market since 2009. Many studies have proven the safety and efficacy of the procedure. Up until now, studies investigating the long-term effect of AIT have been sparse. Read More

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http://dx.doi.org/10.1007/s00417-019-04259-5DOI Listing
February 2019

Surgical treatment of neovascular glaucoma: a systematic review and meta-analysis.

Graefes Arch Clin Exp Ophthalmol 2019 Feb 6. Epub 2019 Feb 6.

Department of Ophthalmology, Hospital Santa Maria, Av Prof. Dr. Egas Moniz, 1649-035, Lisbon, Portugal.

Purpose: This literature review and meta-analysis aims to compare intraocular pressure (IOP) lowering efficacy, failure rates and loss of light perception (LP) rates 6 months after an IOP-lowering surgical procedure in neovascular glaucoma (NVG) eyes.

Methods: MEDLINE and EMBASE were used as data sources. Only studies including NVG patients who underwent two different surgical approaches were considered. Read More

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http://dx.doi.org/10.1007/s00417-019-04256-8DOI Listing
February 2019

Inhibitory role of transforming growth factor β2 in experimental autoimmune anterior uveitis.

Graefes Arch Clin Exp Ophthalmol 2019 Feb 5. Epub 2019 Feb 5.

Department of Ophthalmology, Jones Eye Institute, Pat and Willard Walker Eye Research Center, College of Medicine, University of Arkansas for Medical Sciences, 4301 West Markham, Mail Slot 523, Little Rock, AR, 72205, USA.

Purpose: Experimental autoimmune anterior uveitis (EAAU) is a clinically relevant animal model for human idiopathic anterior uveitis (IAU). The role of the immunomodulator transforming growth factor β2 (TGF-β2) in EAAU pathology is unknown. In this study, we investigated the regulatory role of TGF-β2 in EAAU. Read More

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http://dx.doi.org/10.1007/s00417-019-04255-9DOI Listing
February 2019

Involvement of circulatory disturbance in optic disk melanocytoma with visual dysfunction.

Graefes Arch Clin Exp Ophthalmol 2019 Feb 4. Epub 2019 Feb 4.

Department of Ophthalmology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, N-15, W-7, Kita-ku, Sapporo, 060-8638, Japan.

Purpose: This study aims to examine the relationship between ocular circulation changes and visual field defects in optic disk melanocytoma (ODM).

Methods: Five eyes of five patients were enrolled in this study. All patients were diagnosed with ODM in the Department of Ophthalmology, Hokkaido University Hospital from March 2009 to November 2017. Read More

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http://dx.doi.org/10.1007/s00417-019-04257-7DOI Listing
February 2019

The treatment of amblyopia: current practice and emerging trends.

Graefes Arch Clin Exp Ophthalmol 2019 Jan 31. Epub 2019 Jan 31.

Department of Neuroscience, Psychology and Behaviour, Robert Kilpatrick Clinical Sciences Building, Leicester Royal Infirmary, University of Leicester, Leicester, UK.

Purpose: The purpose of this review is to provide an update on current management and recent research for amblyopia treatment. Part I will review patching, atropine penalization, and pharmacological treatments. Part II will focus on perceptual learning, video gaming, and binocular dichoptic approaches. Read More

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http://dx.doi.org/10.1007/s00417-019-04254-wDOI Listing
January 2019

Comparison of objective accommodation in phakic and pseudophakic eyes between age groups.

Graefes Arch Clin Exp Ophthalmol 2019 Jan 30. Epub 2019 Jan 30.

The Institute of Vision Research, Department of Ophthalmology, Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemun-gu, Seoul, 03722, Republic of Korea.

Purpose: To compare objective accommodation of phakic and pseudophakic eyes between two different age groups.

Methods: Eighty-three eyes (83 participants aged ≥ 40 years) with a visual acuity of 20/25 or better, and refractive error < spherical - 1.0 diopters (D) and cylindrical 1. Read More

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http://dx.doi.org/10.1007/s00417-019-04249-7DOI Listing
January 2019

Lipofuscin-dependent stimulation of microglial cells.

Graefes Arch Clin Exp Ophthalmol 2019 Jan 28. Epub 2019 Jan 28.

Research Laboratory, Department of Ophthalmology, University Medical Center, Domagkstr. 15, D-48149, Münster, Germany.

Purpose: To examine the reaction of microglial cells (MG) when incubated with lipofuscin (LP) in vitro with emphasis on the immunological reaction of the MG toward LP and the suppression of this reaction by immunomodulatory agents. MG are involved in the pathogenesis of degenerative eye disorders such as age-related macular degeneration (AMD). LP is a heterogeneous waste material that accumulates in the retinal pigment epithelium (RPE) cells with advancing age. Read More

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http://dx.doi.org/10.1007/s00417-019-04253-xDOI Listing
January 2019
1 Read

Multimodal imaging of the retina and choroid in healthy Macaca fascicularis at different ages.

Graefes Arch Clin Exp Ophthalmol 2019 Jan 25. Epub 2019 Jan 25.

State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, 510060, China.

Purpose: The aim of this study was to identify the morphological features of the retina and choroid in Macaca fascicularis of different ages using multimodal imaging.

Methods: A total of 27 Macaca fascicularis with no ocular diseases were studied (mean age, 104.2 months; range, 1. Read More

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http://dx.doi.org/10.1007/s00417-019-04237-xDOI Listing
January 2019

OLIMPIC: a 12-month study on the criteria driving retreatment with ranibizumab in patients with visual impairment due to myopic choroidal neovascularization.

Graefes Arch Clin Exp Ophthalmol 2019 Jan 24. Epub 2019 Jan 24.

Novartis Farma SpA, Largo Umberto Boccioni 1, 21040, Origgio, VA, Italy.

Purpose: To evaluate criteria driving retreatment with ranibizumab in Italian patients with myopic choroidal neovascularization (mCNV).

Methods: OLIMPIC was a 12-month, phase IIIb, open-label study. Patients with active mCNV were treated with ranibizumab 0. Read More

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http://dx.doi.org/10.1007/s00417-019-04248-8DOI Listing
January 2019

Use of log-scaled crowded visual acuity charts in clinical studies regarding amblyopia.

Graefes Arch Clin Exp Ophthalmol 2019 Jan 24. Epub 2019 Jan 24.

IInd Department of Ophthalmology, Medical School, Aristotle University of Thessaloniki "Papageorpiou" Hospital, N.Efkarpia, 56429, Thessaloniki, Greece.

Purpose: Log-scaled crowded charts using standardized testing protocol are essential for precise and reproducible visual acuity (VA) testing regarding amblyopia. Despite common acceptance of these standards, current VA testing clinical practice shows considerable diversity. The purpose of this retrospective literature review was to investigate the methodology of VA measurement and reporting in pediatric ophthalmology literature regarding amblyopia. Read More

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http://dx.doi.org/10.1007/s00417-018-04235-5DOI Listing
January 2019
1 Read

Value of ultrasound biomicroscopy in assessment of small masses at medial canthal region.

Graefes Arch Clin Exp Ophthalmol 2019 Jan 23. Epub 2019 Jan 23.

Department of Ophthalmology, Fudan Eye and ENT Hospital, 83 Fen Yang Road, Xuhui District, Shanghai, 200031, China.

Purpose: Conventional imaging techniques are not sensitive enough to reveal detailed structures of lacrimal drainage system (LDS) and its surrounding tissue (ST). Our study aimed to explore utility of ultrasound biomicroscopy (UBM) in assessment of small masses at the medial canthal region and compare performance of UBM with conventional imaging techniques.

Methods: We prospectively recruited cases with small mass (long axis < 1 cm) at the medial canthal region (upper LDS-located area) from June 2017 to October 2018. Read More

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http://dx.doi.org/10.1007/s00417-019-04252-yDOI Listing
January 2019

Magnetic resonance imaging findings of age-related distance esotropia in Japanese patients with high myopia.

Graefes Arch Clin Exp Ophthalmol 2019 Jan 22. Epub 2019 Jan 22.

Department of Ophthalmology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan.

Purpose: This study aimed to investigate the characteristics of the extraocular muscles and the orbital connective tissue pulleys in Japanese patients with age-related distance esotropia (ARDE) and high myopia using magnetic resonance imaging (MRI).

Methods: This was a retrospective case-series study. High-resolution coronal MRI scans of 12 orbits were obtained in 6 patients with ARDE and high myopia (age range: 51-69 years). Read More

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http://dx.doi.org/10.1007/s00417-019-04250-0DOI Listing
January 2019

HMG-CoA reductase expression in human eyelid tissue and in a human meibomian gland epithelial cell line.

Graefes Arch Clin Exp Ophthalmol 2019 Jan 21. Epub 2019 Jan 21.

Save Sight Institute, University of Sydney, Sydney Eye Hospital Campus, 8 Macquarie Street, Sydney, NSW, 2000, Australia.

Purpose: 3-Hydroxy-3-methyl-glutaryl-coenzyme A reductase (HMGCR), the rate-limiting enzyme of cholesterol production, has been found to contribute to lipid secretion from skin sebaceous glands and hair follicles. We assessed for HMGCR expression in human eyelid tissue and in immortalized human meibomian gland epithelial cells (HMGECs) using immunohistochemistry.

Methods: Full thickness human eyelid specimens in archival paraffin blocks were obtained. Read More

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http://dx.doi.org/10.1007/s00417-019-04247-9DOI Listing
January 2019
3 Reads

Infrared photographs with a selective wavelength filter to diagnose small-angle esotropia in young children.

Graefes Arch Clin Exp Ophthalmol 2019 Jan 19. Epub 2019 Jan 19.

Department of Ophthalmology, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, South Korea.

Purpose: To validate the effectiveness of the selective wavelength filter analysis with infrared photographs for diagnosing small-angle esotropia in children under age 4.

Methods: This is a retrospective, observational, case-control study. A total of 83 esotropes with an esodeviation of ≤ 16 prism diopters (PD) and 75 orthotropic controls under 4 years of age were included. Read More

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http://dx.doi.org/10.1007/s00417-019-04240-2DOI Listing
January 2019
1 Read

Requirement of age-dependent normalization of spectral-domain optical coherent tomography parameters in non-human primates for translational studies.

Authors:
Marc M Abitbol

Graefes Arch Clin Exp Ophthalmol 2019 Jan 19. Epub 2019 Jan 19.

Centre de Recherches des Cordeliers, UMR-S INSERM no.1138 Team 17, Hôpital Universitaire Necker-Enfants Malades, Assistance Publique-Hôpitaux de Paris, Université Paris Descartes, 75015, Paris, France.

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http://dx.doi.org/10.1007/s00417-019-04238-wDOI Listing
January 2019

Intrascleral fixation of intraocular lens haptics: histological advantages in a comparison with scleral suture fixation in rabbits.

Graefes Arch Clin Exp Ophthalmol 2019 Jan 19. Epub 2019 Jan 19.

Department of Oculoplastic, Orbital and Lacrimal Surgery, Aichi Medical University Hospital, Aichi, Japan.

Purpose: To disclose histological advantages of intrascleral fixation of intraocular lens haptics, in comparison with scleral suture fixation, in a study with rabbits.

Methods: Ten white rabbits, 10 weeks of age, were used in this experimental histopathological study. After unilateral lensectomy and anterior vitrectomy, an intraocular lens haptic was inserted into one eye of each rabbit. Read More

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http://link.springer.com/10.1007/s00417-019-04243-z
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http://dx.doi.org/10.1007/s00417-019-04243-zDOI Listing
January 2019
6 Reads

Phenotypic spectrum of autosomal recessive retinitis pigmentosa without posterior column ataxia caused by mutations in the FLVCR1 gene.

Graefes Arch Clin Exp Ophthalmol 2019 Jan 17. Epub 2019 Jan 17.

Institute for Ophthalmic Research, Molecular Genetics Laboratory, Eberhard Karls University Tuebingen, Tuebingen, Germany.

Purpose: Posterior column ataxia and retinitis pigmentosa (PCARP) is a rare form of syndromic RP associated with mutations in the FLVCR1 gene. Recent evidence has suggested a spectrum in the phenotype depending on the genotype.

Methods: Six individuals with retinitis pigmentosa (RP) carrying mutations in the FLVCR1 gene underwent detailed ophthalmological examinations at the Center for Ophthalmology and two of these also an extensive neurological examination at the Department of Neurology in Tuebingen, Germany. Read More

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http://link.springer.com/10.1007/s00417-018-04233-7
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http://dx.doi.org/10.1007/s00417-018-04233-7DOI Listing
January 2019
6 Reads

Inflammatory responses after vitrectomy with vitreous substitutes in a rabbit model.

Graefes Arch Clin Exp Ophthalmol 2019 Jan 17. Epub 2019 Jan 17.

Department of Ophthalmology, Lund University, BMC D10, 22184, Lund, Sweden.

Purpose: To investigate the inflammatory response of current and future potential vitreous substitutes in an experimental in vivo vitrectomy model.

Methods: Twenty-five gauge pars plana vitrectomy was performed in the right eye of 60 pigmented rabbits, with subsequent injection of 0.5-1. Read More

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http://dx.doi.org/10.1007/s00417-019-04242-0DOI Listing
January 2019

Simulators in the training of surgeons: is it worth the investment in money and time? 2018 Jules Gonin lecture of the Retina Research Foundation.

Graefes Arch Clin Exp Ophthalmol 2019 Jan 15. Epub 2019 Jan 15.

Copenhagen Academy for Medical Education and Simulation, Centre for HR, Copenhagen, Capital Region of Denmark, Denmark.

This paper describes transfer of skills obtained from training with the EyeSI virtual reality simulator of ophthalmic surgery to real-life surgical performance. Skills in real-life phacoemulsification surgery were assessed by systematic blinded evaluation of surgical videos based on the OSACCS system. Nineteen Danish cataract surgeons with varying clinical experience levels had their cataract surgery skills evaluated before and after completing a standardized mastery learning program on the EyeSI. Read More

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http://link.springer.com/10.1007/s00417-019-04244-y
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http://dx.doi.org/10.1007/s00417-019-04244-yDOI Listing
January 2019
2 Reads

Depressive symptoms, resilience, and personality traits in dry eye disease.

Graefes Arch Clin Exp Ophthalmol 2019 Jan 15. Epub 2019 Jan 15.

Department of Ophthalmology, University Hospital Düsseldorf, Heinrich-Heine-University, Düsseldorf, Germany.

Purpose: Dry eye disease (DED) is a multifactorial disease of the ocular surface that leads to symptoms of discomfort and reduces quality of life. Several studies have shown an association with depression. We investigated the prevalence of depressive symptoms and their severity in DED patients and examined whether depressive symptoms correlate with signs, symptoms, or subtypes of DED or with psychological factors (resilience, premorbid personality, and subjective well-being). Read More

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http://dx.doi.org/10.1007/s00417-019-04241-1DOI Listing
January 2019
1 Read

Efficacy and safety of ranibizumab 0.5 mg in Chinese patients with visual impairment due to diabetic macular edema: results from the 12-month REFINE study.

Graefes Arch Clin Exp Ophthalmol 2019 Jan 15. Epub 2019 Jan 15.

Department of Ophthalmology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.

Purpose: To demonstrate the efficacy and safety of ranibizumab 0.5 mg pro re nata (PRN) versus laser photocoagulation for the treatment of Chinese patients with visual impairment due to diabetic macular edema (DME).

Methods: REFINE was a phase III, 12-month, double-masked, multicenter, laser-controlled study in patients (aged ≥ 18 years) with DME. Read More

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http://dx.doi.org/10.1007/s00417-018-04213-xDOI Listing
January 2019
1 Read
1.908 Impact Factor

An experimental and clinical study on the initial experiences of Brazilian vitreoretinal surgeons with heads-up surgery.

Graefes Arch Clin Exp Ophthalmol 2019 Jan 15. Epub 2019 Jan 15.

From the Department of Ophthalmology-Retina, Federal University of São Paulo, São Paulo, Brazil.

Purpose: To evaluate the initial experiences of several vitreoretinal surgeons in Brazil, both experienced and beginners, with a three-dimensional (3D) system, and to report the advantages and disadvantages of this technology. We also report surgical manipulations performed using the heads-up method in porcine eyes. For full-thickness idiopathic macular holes (MHs), we analyzed the times required for pars plana vitrectomy (PPV) and internal limiting membrane (ILM) rhexis by using traditional microscopy and 3D system, and to evaluate anatomical surgical results. Read More

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http://link.springer.com/10.1007/s00417-019-04246-w
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http://dx.doi.org/10.1007/s00417-019-04246-wDOI Listing
January 2019
4 Reads

Is primary open-angle glaucoma an ocular manifestation of systemic disease?

Graefes Arch Clin Exp Ophthalmol 2019 Jan 15. Epub 2019 Jan 15.

Glaucoma Research Center, Wills Eye Hospital, 840 Walnut Street, Suite 1140, Philadelphia, PA, 19107, USA.

Primary open-angle glaucoma is currently characterized by a pattern of progressive retinal ganglion cell loss that stems from a complex underlying pathophysiology that remains poorly elucidated. The roles of blood flow and intraocular pressure (IOP) in glaucoma pathogenesis have been extensively studied. Further, it has been established that lowering IOP can slow the progression of glaucoma. Read More

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http://dx.doi.org/10.1007/s00417-019-04239-9DOI Listing
January 2019

Effect of intravitreal injection of aflibercept or ranibizumab on chorioretinal atrophy in myopic choroidal neovascularization.

Graefes Arch Clin Exp Ophthalmol 2019 Jan 14. Epub 2019 Jan 14.

Department of Ophthalmology, Osaka University Medical School, Osaka, Japan.

Purpose: To compare chorioretinal atrophy (CRA) progression in myopic choroidal neovascularization (mCNV) between intravitreal injections of ranibizumab (IVR) and aflibercept (IVA) in the eyes with mCNV.

Methods: Thirty eyes (28 patients) with treatment-naïve mCNV were included in this study. IVR or IVA was administered for up to 1 year. Read More

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http://link.springer.com/10.1007/s00417-018-04214-w
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http://dx.doi.org/10.1007/s00417-018-04214-wDOI Listing
January 2019
2 Reads

Comparison of the posterior corneal elevation and biomechanics after SMILE and LASEK for myopia: a short- and long-term observation.

Graefes Arch Clin Exp Ophthalmol 2019 Jan 14. Epub 2019 Jan 14.

Department of Ophthalmology, Eye and ENT Hospital, Fudan University, No. 83 Fenyang Road, Shanghai, 200031, China.

Purpose: This study compares the posterior corneal elevation and corneal biomechanics after small incision lenticule extraction (SMILE) and laser-assisted subepithelial keratomileusis (LASEK) for myopia correction in a short- and long-term observation.

Methods: This prospective study included 32 patients in the SMILE group and 32 patients in the LASEK group. Corneal posterior central elevation (PCE), posterior mean elevation (PME), corneal back power (Kb), and anterior chamber depth (ACD) were evaluated with Pentacam, and intraocular pressure (IOP), corneal hysteresis (CH), and corneal resistance factor (CRF) were evaluated with the ORA at pre-operation and 3 months and 3 years post-operation. Read More

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http://link.springer.com/10.1007/s00417-018-04227-5
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http://dx.doi.org/10.1007/s00417-018-04227-5DOI Listing
January 2019
5 Reads

In vivo confocal microscopy morphometric analysis of corneal subbasal nerve plexus in dry eye disease using newly developed fully automated system.

Graefes Arch Clin Exp Ophthalmol 2019 Jan 14. Epub 2019 Jan 14.

Ophthalmology Unit, DIMES, S.Orsola-Malpighi University Hospital, University of Bologna, Via Palagi 9, 40138, Bologna, Italy.

Purpose: To evaluate in vivo confocal microscopy (IVCM) features of corneal subbasal nerve plexus (SNP) in the setting of dry eye disease (DED) using fully automated software "ACCMetrics," and to further investigate its diagnostic performance in discriminating DED patients.

Methods: IVCM exams of SNP in DED patients and matched control subjects were performed using Heidelberg Retina Tomograph with the Rostock Cornea Module. The following parameters were obtained with ACCMetrics: corneal nerve fiber density (CNFD), corneal nerve branch density (CNBD), corneal nerve fiber length (CNFL), corneal nerve total branch density (CTBD), corneal nerve fiber area (CNFA), corneal nerve fiber width (CNFW), and corneal nerve fractal dimension (CNFrD). Read More

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http://dx.doi.org/10.1007/s00417-018-04225-7DOI Listing
January 2019

Relationship between the morphology of the foveal avascular zone and the degree of aniseikonia before and after vitrectomy in patients with unilateral epiretinal membrane.

Graefes Arch Clin Exp Ophthalmol 2019 Jan 14. Epub 2019 Jan 14.

Hayashi Eye Hospital, 4-23-35, Hakataekimae, Fukuoka, 812-0011, Japan.

Purpose: Persistent metamorphopsia, particularly aniseikonia, is a troublesome problem which may occur after epiretinal membrane (ERM) surgery. To clarify if the preoperative foveal avascular zone (FAZ) morphology can be used as a predictor of postoperative residual aniseikonia, the morphological changes in the FAZ and the degree of aniseikonia between before and 12 months after vitrectomy for epiretinal membrane (ERM) were measured and analyzed.

Methods: Thirty patients, each with a unilateral idiopathic ERM, who underwent treatment between September 2016 and March 2017 were enrolled for this prospective case series study. Read More

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http://dx.doi.org/10.1007/s00417-019-04245-xDOI Listing
January 2019

Fundus autofluorescence and ellipsoid zone (EZ) line width can be an outcome measurement in RHO-associated autosomal dominant retinitis pigmentosa.

Graefes Arch Clin Exp Ophthalmol 2019 Jan 11. Epub 2019 Jan 11.

Department of Ophthalmology, Columbia University, New York, NY, USA.

Purpose: To evaluate the progression of retinitis pigmentosa (RP) due to mutations in rhodopsin (RHO) by measuring the short-wavelength autofluorescence (SW-AF) increased autofluorescence ring and ellipsoid zone (EZ)-line width.

Methods: Fundus autofluorescence (FAF) and spectral domain optical coherence tomography (SD-OCT) images were obtained from 10 patients with autosomal dominant RP due to mutations in the RHO gene. Measurements of ring area on FAF images, as well as the EZ line width on SD-OCT images and horizontal, vertical diameter, were performed by two independent masked graders. Read More

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http://link.springer.com/10.1007/s00417-018-04234-6
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http://dx.doi.org/10.1007/s00417-018-04234-6DOI Listing
January 2019
3 Reads

Fovea-sparing rhegmatogenous retinal detachments: impact of clinical factors including time to surgery on visual and anatomic outcomes.

Graefes Arch Clin Exp Ophthalmol 2019 Jan 11. Epub 2019 Jan 11.

Retina Consultants of Houston, 6560 Fannin Street, Suite 750, Houston, TX, 77030, USA.

Purpose: Evaluate the impact of time to surgery and other clinical factors on visual and anatomic outcomes following surgical repair of fovea-sparing rhegmatogenous retinal detachments (RRD).

Methods: Visual and anatomic outcomes were analyzed for their association with clinical factors, including lens status, preoperative visual acuity (VA), contralateral RRD, RRD symptom duration, time to surgery, single-operation anatomic success, number of quadrants involved, posterior RRD extent, RRD extent closest to the fovea, number of retinal breaks, quadrants with retinal breaks, and surgery performed Saturday or Sunday versus Monday-Friday.

Results: Medical records of 423 eyes with fovea-sparing RRD repaired with pneumatic retinopexy (PR), scleral buckle (SB), pars plana vitrectomy (PPV), and PPV with SB (PPV/SB) were included. Read More

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http://link.springer.com/10.1007/s00417-018-04236-4
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http://dx.doi.org/10.1007/s00417-018-04236-4DOI Listing
January 2019
6 Reads
1.908 Impact Factor

Effectiveness of multifocal and monofocal intraocular lenses for cataract surgery and lens replacement: a systematic review and meta-analysis.

Graefes Arch Clin Exp Ophthalmol 2019 Jan 10. Epub 2019 Jan 10.

West Los Angeles Veterans Affairs Medical Center, 11301 Wilshire Blvd, Building 500, Los Angeles, CA, 90073, USA.

Purpose: Multifocal intraocular lenses (IOLs) offer the possibility of spectacle-free vision following cataract surgery compared to standard IOLs. Existing systematic reviews have generally concluded that multifocal IOLs result in better uncorrected near vision and greater spectacle independence, but more unwanted visual phenomena such as glare and halos, compared to monofocal IOLs. However, the certainty of evidence has been low for most outcomes, and pooled analyses have grouped together technologically obsolete lenses with newer lenses, potentially obscuring differences in performance across different lens types. Read More

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http://link.springer.com/10.1007/s00417-018-04218-6
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http://dx.doi.org/10.1007/s00417-018-04218-6DOI Listing
January 2019
10 Reads

In vivo imaging of the fibrillar architecture of the posterior vitreous and its relationship to the premacular bursa, Cloquet's canal, prevascular vitreous fissures, and cisterns.

Graefes Arch Clin Exp Ophthalmol 2019 Jan 8. Epub 2019 Jan 8.

Vitreous Retina Macula Consultants of New York, 460 Park Avenue, 5th floor, New York, NY, 10022, USA.

Purpose: To describe the fibrillar architecture of the posterior cortical vitreous and identify variations across eyes of different axial lengths in vivo.

Methods: Sixty-four eyes of 32 subjects were examined with swept-source optical coherence tomography (SS-OCT). Grading of vitreous degeneration, presence of vitreous cisterns/lacunae, posterior hyaloid status, directionality of vitreous fibers and their relations to vitreous spaces, and lamellar reflectivity of the posterior vitreous were assessed. Read More

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http://dx.doi.org/10.1007/s00417-018-04221-xDOI Listing
January 2019

Increased soluble urokinase plasminogen activator receptor (suPAR) levels in neovascular age-related macular degeneration: a role for inflammation in the pathogenesis of the disease?

Graefes Arch Clin Exp Ophthalmol 2019 Jan 7. Epub 2019 Jan 7.

Complications of Diabetes Unit, Diabetes Research Institute, IRCCS San Raffaele Scientific Institute, Milan, Italy.

Purpose: To evaluate the plasma concentration of the soluble form of the urokinase-type plasminogen activator receptor ((s)uPAR), an established biomarker of chronic inflammation, in patients affected by neovascular age-related macular degeneration.

Methods: Forty consecutive patients affected by age-related macular degeneration and 52 subjects with no history of the disease were included in this case-control study. The two groups of individuals considered for the study were matched for age, sex, and class of medications taken. Read More

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http://dx.doi.org/10.1007/s00417-018-04230-wDOI Listing
January 2019

Fundus autofluorescence and spectral domain optical coherence tomography as predictors for long-term functional outcome in rhegmatogenous retinal detachment.

Graefes Arch Clin Exp Ophthalmol 2019 Jan 7. Epub 2019 Jan 7.

Department of Ophthalmology, Odense University Hospital, Sdr. Boulevard 29, DK-5000, Odense, Denmark.

Purpose: To detect pre- and postoperative retinal changes in fundus autofluorescence (AF) and spectral domain optical coherence tomography (SD-OCT) and to correlate these with functional outcome in patients with primary rhegmatogenous retinal detachment (RRD).

Methods: A prospective, 30-month study of patients operated with 25-gauge vitrectomy for primary RRD. Patients were examined preoperatively and after 6 and 30 months, using ultrawide-field AF images (UWFI) (Optos 200Tx) and SD-OCT (Topcon 3D OCT-2000) imaging. Read More

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http://dx.doi.org/10.1007/s00417-018-04222-wDOI Listing
January 2019
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Age-related differences in the prevalence of subtypes of Neovascular age-related macular degeneration in the first diagnosed eye.

Graefes Arch Clin Exp Ophthalmol 2019 Jan 7. Epub 2019 Jan 7.

Department of Ophthalmology, Kim's Eye Hospital, Konyang University College of Medicine, #156 Youngdeungpo-dong 4ga, Youngdeungpo-gu, Seoul, 150-034, South Korea.

Purpose: To evaluate age-related differences in the prevalence of subtypes of neovascular age-related macular degeneration (AMD) in the first diagnosed eye.

Methods: This retrospective, observational study included 1099 eyes of 1099 patients diagnosed with neovascular AMD. The neovascular AMD cases were classified into three subtypes: typical neovascular AMD, polypoidal choroidal vasculopathy (PCV), and type 3 neovascularization. Read More

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http://link.springer.com/10.1007/s00417-018-04228-4
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http://dx.doi.org/10.1007/s00417-018-04228-4DOI Listing
January 2019
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Vascular and structural alterations of the choroid evaluated by optical coherence tomography angiography and optical coherence tomography after half-fluence photodynamic therapy in chronic central serous chorioretinopathy.

Graefes Arch Clin Exp Ophthalmol 2019 Jan 7. Epub 2019 Jan 7.

Department of Ophthalmology, Ankara University Faculty of Medicine Ankara, Mamak Street, Dikimevi, Ankara, Turkey.

Purpose: To concurrently evaluate the effect of half-fluence photodynamic therapy (hf PDT) on choriocapillaris (CC) perfusion and choroidal structure in chronic central serous chorioretinopathy (CSC).

Methods: This prospective study included 48 eyes of 41 patients with chronic CSC. Enhanced depth imaging optical coherence tomography and optical coherence tomography angiography (OCTA) images were analyzed. Read More

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http://link.springer.com/10.1007/s00417-018-04226-6
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http://dx.doi.org/10.1007/s00417-018-04226-6DOI Listing
January 2019
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Multiple subretinal fluid blebs after pars plana vitrectomy for rhegmatogenous retinal detachment repair.

Graefes Arch Clin Exp Ophthalmol 2019 Jan 6. Epub 2019 Jan 6.

Department of Ophthalmology, Hidaka Medical Center, Toyooka, Japan.

Purpose: To investigate the incidence of and clinical risk factors for multiple subretinal fluid (SRF) blebs after pars plana vitrectomy (PPV).

Methods: This study examined patients who underwent PPV (25- or 27-gauge) to repair a primary rhegmatogenous retinal detachment (RRD). Clinical characteristics, including age, sex, axial length, symptom duration, and postoperative best-corrected visual acuity (BCVA), were compared between eyes with and without multiple SRF blebs. Read More

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http://dx.doi.org/10.1007/s00417-018-04231-9DOI Listing
January 2019
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Impact of segmentation density on spectral domain optical coherence tomography assessment in Stargardt disease.

Graefes Arch Clin Exp Ophthalmol 2019 Jan 6. Epub 2019 Jan 6.

Doheny Eye Institute, 1355 San Pablo Street DVRC211, Los Angeles, CA, 90033, USA.

Purpose: Automated spectral domain optical coherence tomography (SD-OCT) segmentation algorithms currently do not perform well in segmenting individual intraretinal layers in eyes with Stargardt disease (STGD). We compared selective B-scan segmentation strategies for generating mean retinal layer thickness and preserved area data from SD-OCT scans in patients with STGD1.

Methods: Forty-five eyes from 40 Stargardt patients were randomly selected from the ongoing Natural History of the Progression of Atrophy Secondary to Stargardt Disease (ProgStar) study. Read More

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http://dx.doi.org/10.1007/s00417-018-04229-3DOI Listing
January 2019

Incidence and timing of recurrence of optic neuritis.

Graefes Arch Clin Exp Ophthalmol 2019 Jan 5. Epub 2019 Jan 5.

Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.

Purpose: To describe the incidence and timing of recurrence in patients with optic neuritis (ON).

Methods: Medical documents of adult patients with ON were retrospectively reviewed. The incidence and timing of recurrence of an ON episode were analyzed. Read More

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http://link.springer.com/10.1007/s00417-018-04217-7
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http://dx.doi.org/10.1007/s00417-018-04217-7DOI Listing
January 2019
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Bevacizumab versus bevacizumab and macular grid photocoagulation for macular edema in eyes with non-ischemic branch retinal vein occlusion: results from a prospective randomized study.

Graefes Arch Clin Exp Ophthalmol 2019 Jan 4. Epub 2019 Jan 4.

Department of Ophthalmology, University Medical Center Goettingen, Robert-Koch-Str 40, 37075, Goettingen, Germany.

Background: The objective of the study was the investigation of the effects of intravitreal bevacizumab (BEV) with or without additional macular grid laser photocoagulation (GRID) for macular edema (ME) secondary to branch retinal vein occlusion (BRVO).

Methods: Prospective, randomized, monocentric study. Thirty-two patients were included. Read More

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http://dx.doi.org/10.1007/s00417-018-04223-9DOI Listing
January 2019

Ahmed glaucoma valve implantation versus suprachoroidal silicone tube implantation following the injection of bevacizumab into the anterior chamber in patients with neovascular glaucoma.

Graefes Arch Clin Exp Ophthalmol 2019 Jan 4. Epub 2019 Jan 4.

Department of Ophthalmology, School of Medicine, Eskişehir Osmangazi University, Eskişehir, Turkey.

Purpose: This study compared the efficacy and safety of Ahmed glaucoma valve (AGV) implantation versus suprachoroidal silicone tube (SST) implantation after the injection of bevacizumab into the anterior chamber in patients with neovascular glaucoma.

Methods: Patients were randomly assigned to undergo AGV or SST implantation. Bevacizumab was injected into the anterior chamber at a dosage of 1. Read More

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http://dx.doi.org/10.1007/s00417-018-04219-5DOI Listing
January 2019

Fully automated detection of retinal disorders by image-based deep learning.

Graefes Arch Clin Exp Ophthalmol 2019 Jan 4. Epub 2019 Jan 4.

Department of Precision Mechanical Engineering, Shanghai University, Shanghai, 200072, China.

Purpose: With the aging population and the global diabetes epidemic, the prevalence of age-related macular degeneration (AMD) and diabetic macular edema (DME) diseases which are the leading causes of blindness is further increasing. Intravitreal injections with anti-vascular endothelial growth factor (anti-VEGF) medications are the standard of care for their indications. Optical coherence tomography (OCT), as a noninvasive imaging modality, plays a major part in guiding the administration of anti-VEGF therapy by providing detailed cross-sectional scans of the retina pathology. Read More

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http://dx.doi.org/10.1007/s00417-018-04224-8DOI Listing
January 2019
1.908 Impact Factor

A new dye based on anthocyanins from the acai fruit (Euterpe oleracea) for chromovitrectomy in humans: clinical trial results.

Graefes Arch Clin Exp Ophthalmol 2019 Jan 3. Epub 2019 Jan 3.

Vision Institute, Department of Ophthalmology, Federal University of São Paulo, 781, Pedro de Toledo Street, 2nd floor, São Paulo, 04039-032, Brazil.

Purpose: To test the applicability of the acai dye at a 25% concentration for identifying the posterior hyaloids and internal limiting membranes (ILMs) during pars plana vitrectomy (PPV) in human eyes with macular holes (MHs).

Methods: This study included 25 patients with chronic idiopathic MHs. The exclusion criteria included glaucoma, previous significant ocular conditions, and previous ocular surgeries except uncomplicated cataract. Read More

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http://dx.doi.org/10.1007/s00417-018-04204-yDOI Listing
January 2019

Efficacy of a Novel Retrobulbar Extension Shunt to Rescue Eyes with Fibrotic Encapsulated Blebs and Uncontrolled Ocular Hypertension.

Graefes Arch Clin Exp Ophthalmol 2019 Jan 3. Epub 2019 Jan 3.

University of Texas Health Science Center at San Antonio Long School of Medicine, San Antonio, TX, USA.

Purpose: Retrobulbar glaucoma shunts are large-bore fenestrated silicone stents that redirect aqueous humor into the retrobulbar space. They were designed to rescue failed standard tube shunts with fibrotic encapsulation in patients with intractable ocular hypertension. This article evaluates longer-term outcomes of a larger population undergoing retrobulbar aqueous redirection. Read More

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http://dx.doi.org/10.1007/s00417-018-4186-3DOI Listing
January 2019
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Identification of novel PROM1 mutations responsible for autosomal recessive maculopathy with rod-cone dystrophy.

Graefes Arch Clin Exp Ophthalmol 2018 Dec 26. Epub 2018 Dec 26.

Department of Ophthalmology, Shanghai General Hospital (Shanghai First People's Hospital), Shanghai Jiao Tong University School of Medicine, 100 Haining Road, Shanghai, 200080, China.

Purpose: To characterize two patients with macular and rod-cone dystrophy and identify the genetic basis for disease.

Method: Ophthalmic examinations were performed for the family and the peripheral blood samples were collected for whole exome sequencing. The mutated sequences of PROM1 gene were cloned and expressed in cultured cell lines after transient transfection followed by analysis with confocal microscopy and bridge-PCR. Read More

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http://link.springer.com/10.1007/s00417-018-04206-w
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http://dx.doi.org/10.1007/s00417-018-04206-wDOI Listing
December 2018
6 Reads

Development of a novel noninvasive system for measurement and imaging of the arterial phase oxygen density ratio in the retinal microcirculation.

Graefes Arch Clin Exp Ophthalmol 2018 Dec 19. Epub 2018 Dec 19.

Department of Ophthalmology, Faculty of Medicine, Saga University, 5-1-1 Nabeshima, Saga, 849-8501, Japan.

Purpose: This study was conducted in order to develop a novel noninvasive system for measurement and imaging of the arterial oxygen density ratio (ODR) in the retinal microcirculation.

Methods: We developed a system composed of two digital cameras with two different filters, which were attached to a fundus camera capable of simultaneously obtaining two images. Actual measurements were performed on healthy volunteer eyes (n = 61). Read More

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http://dx.doi.org/10.1007/s00417-018-04211-zDOI Listing
December 2018
7 Reads