641 results match your criteria Gout and Pseudogout


Clinical Presentation, Management, and Prognosis of Pseudogout in Joint Arthroplasty: A Retrospective Cohort Study.

J Bone Jt Infect 2019 1;4(1):20-26. Epub 2019 Jan 1.

Division of Infectious Diseases, Department of Internal Medicine, Mayo Clinic School of Graduate Medical Education. 200 1st St SW, Rochester, MN 55905.

Calcium pyrophosphate deposition disease (CPPD), or pseudogout, is rare in prosthetic joints, but can mimic prosthetic joint infection (PJI) according to case reports. The purpose of this case series is to describe the demographics, presentation, management, and outcomes of a cohort of these patients seen at our academic medical center. Patients with post-implant pseudogout, who were evaluated at our medical center between January 1, 2000 and June 30, 2016, were identified from our EHR. Read More

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http://dx.doi.org/10.7150/jbji.29983DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367192PMC
January 2019

Patients Presenting with a Hot, Swollen Joint: a Single-Centre Retrospective Analysis.

Curr Rheumatol Rev 2019 Jan 21. Epub 2019 Jan 21.

Division of Trauma & Orthopaedics, Addenbrooke's Hospital, University of Cambridge, Cambridge, CB2 0QQ. United Kingdom.

A hot, swollen joint is a common clinical condition encountered in the ED and elective orthopaedic and rheumatology clinics. These patients can be difficult to manage and properly treat. The aim of this study was to report a single centre retrospective analysis of patients presenting to our institution for a hot, swollen joint over a three-month period. Read More

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http://dx.doi.org/10.2174/1573397115666190122113659DOI Listing
January 2019
6 Reads

Utility of Anakinra in Acute Crystalline Diseases: A Retrospective Study Comparing a University Hospital with a Veterans Affairs Medical Center.

J Rheumatol 2018 Nov 15. Epub 2018 Nov 15.

From the Division of Arthritis and Rheumatic Diseases, Oregon Health & Science University; Rheumatology Section, Veterans Affairs (VA) Portland Health Care System, Portland, Oregon, USA. J. Desmarais, MD, Division of Arthritis and Rheumatic Diseases, Oregon Health & Science University; C.Q. Chu, MD, PhD, Division of Arthritis and Rheumatic Diseases, Oregon Health & Science University, and Rheumatology Section, VA Portland Health Care System. Address correspondence to Dr. J. Desmarais, 3181 SW Sam Jackson Park Road, Mail Code OP 09, Portland, Oregon 97239, USA. E-mail: Accepted for publication August 15, 2018.

Objective: To evaluate the efficacy and safety of anakinra in inpatient management of acute gout and pseudogout.

Methods: Hospitalized patients with acute gout (n = 77) or pseudogout (n = 11) or both (n = 3) were analyzed for response to anakinra and adverse effects.

Results: Half of all patients had comorbidities limiting the treatment choice. Read More

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http://www.jrheum.org/lookup/doi/10.3899/jrheum.180393
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http://dx.doi.org/10.3899/jrheum.180393DOI Listing
November 2018
6 Reads

Coexisting polyarticular septic arthritis, gout and pseudogout.

BMJ Case Rep 2018 Oct 28;2018. Epub 2018 Oct 28.

Infectious Diseases, Blacktown Mount Druitt Hospital, Blacktown, New South Wales, Australia.

A case of a 67-year-old man with coexisting polyarticular septic arthritis due to group G , gout and pseudogout is presented. Septic arthritis of the left knee joint was further complicated by the development of an adjacent osteomyelitis. Appropriate management led to a full clinical recovery. Read More

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http://casereports.bmj.com/lookup/doi/10.1136/bcr-2018-22681
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http://dx.doi.org/10.1136/bcr-2018-226810DOI Listing
October 2018
9 Reads

A Case of Tophaceous Pseudogout on 18F-FDG PET/CT Imaging.

Clin Nucl Med 2019 Feb;44(2):e98-e100

From the Department of Nuclear Medicine, West China Hospital of Sichuan University, Chengdu, Sichuan, China.

A 53-year-old man with a 10-year history of gout was admitted to our hospital due to chronic low back pain. Initial CT examinations showed a high-density mass with bone destruction of bilateral facet joints at the L3 to L5 level. MRI findings also revealed lesion with the dural sac compression. Read More

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http://Insights.ovid.com/crossref?an=00003072-900000000-9742
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http://dx.doi.org/10.1097/RLU.0000000000002308DOI Listing
February 2019
12 Reads

Severe calcium pyrophosphate dihydrate deposition disease of the metacarpophalangeal joints.

BMJ Case Rep 2018 Sep 28;2018. Epub 2018 Sep 28.

Medicine/Rheumatology, University of Kentucky, Lexington, Kentucky, USA.

We report a case of calcium pyrophosphate deposition disease (CPPD) with an unusual presentation of severe chondrocalcinosis with atypical large burden deposited in the metacarpophalangeal joints as well as more typical deposition in wrists and knees as demonstrated on plain radiographs. A 77-year-old African-American woman 1-year status post parathyroidectomy for hyperparathyroidism initially presented to the rheumatology clinic to treat suspected rheumatoid arthritis given her pattern of joint involvement but was found to have CPPD. The patient's history is notable for end-stage renal disease which complicates medical management. Read More

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http://dx.doi.org/10.1136/bcr-2018-226132DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6169684PMC
September 2018
9 Reads

[Histopathological classification principles of rheumatic joint diseases : Contribution of pathology to the diagnosis].

Orthopade 2018 Nov;47(11):939-946

Unfallchirurgische Klinik, Sektion obere Extremität, Fuß- und Rheumachirurgie, Medizinische Hochschule Hannover, Hannover, Deutschland.

Even though the diagnostics of rheumatic joint diseases are mostly based on clinical, immunoserological and imaging criteria, histopathology can also make a significant contribution. This is particularly true for clinically unclear monoarticular and periarticular diseases. The contribution of histopathology to the diagnosis of rheumatic diseases is manifold since the histopathological differential diagnosis includes the complete spectrum of synovial diseases. Read More

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http://dx.doi.org/10.1007/s00132-018-3649-xDOI Listing
November 2018
2 Reads

Crystallising the role of adrenocorticotrophic hormone in the management of acute gout: a review.

Authors:
Muhammad K Nisar

Clin Exp Rheumatol 2019 Jan-Feb;37(1):137-145. Epub 2018 Aug 29.

Luton and Dunstable University Hospital NHSFT, Luton, UK.

Objectives: Acute gout is traditionally treated with NSAIDs, corticosteroids, and colchicine. However, the presence of comorbid conditions and advancing age, often seen in hospitalised patients, may prevent their use. We reviewed the published data on the use of ACTH in the treatment of acute gouty arthritis. Read More

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August 2018
4 Reads

Localised foot and ankle amyloid deposition.

Pathol Res Pract 2018 Oct 27;214(10):1661-1666. Epub 2018 Aug 27.

Department of Histopathology, NDORMS, University of Oxford, Nuffield Orthopaedic Centre, Oxford, OX3 7HE, UK. Electronic address:

Background: Localised (transthyretin-associated) amyloid is commonly seen in articular/periarticular tissues of elderly individuals. Whether age-associated, amyloid deposition occurs in foot and ankle (F&A) tissues has not previously been investigated. In this study we assessed the nature and frequency of F&A amyloid deposition and determined whether it is associated with age and/or specific articular/periarticular F&A lesions. Read More

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http://dx.doi.org/10.1016/j.prp.2018.08.027DOI Listing
October 2018
2 Reads

Clinical features and risk of recurrence of acute calcium pyrophosphate crystal arthritis.

Clin Exp Rheumatol 2018 Jul 19. Epub 2018 Jul 19.

Division of Rheumatology, Department of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.

Objectives: It is unclear whether attack recurrence rates are similar between acute calcium pyrophosphate (CPP) crystal arthritis and gout. This study compared the clinical features and recurrence rates of both conditions.

Methods: In this retrospective study, we reviewed 106 patients with acute CPP crystal arthritis (based on the presence of CPP crystals and/or chondrocalcinosis) and 173 patients with gout (based on the presence of monosodium urate crystals). Read More

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July 2018
7 Reads

[Update on Gout and Calcium pyrophosphate deposition (CPPD)].

Dtsch Med Wochenschr 2018 Aug 7;143(16):1157-1166. Epub 2018 Aug 7.

The metabolic diseases gout and calciumpyrophosphate deposition (CPPD) (formerly: chondrocalcinosis/pseudogout) are crystal arthropathies which are caused by crystals in synovial fluid and in the case of gout also in periarticular structures. Today, in particular gout is considered as an auto-inflammatory process since phagocytosis of monosodium urate crystals by monocytes/macrophages results in the activation of the innate immune system by activation of the NRLP3-Inflammasome and consecutive secretion of the key cytokine interleukin-1ß and other pro-inflammatory cytokines. The prevalence of both crystal arthropathies rises with increasing age of patients. Read More

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http://dx.doi.org/10.1055/a-0504-5684DOI Listing
August 2018
3 Reads

Does early seronegative arthritis develop into rheumatoid arthritis? A 10-year observational study.

Clin Exp Rheumatol 2019 Jan-Feb;37(1):37-43. Epub 2018 Jun 7.

Department of Rheumatology, Central Hospital of Central Finland, Jyväskylä, Finland.

Objectives: To investigate the 10-year clinical course of patients with seronegative arthritis with the emphasis of reclassification of diagnoses when applicable.

Methods: A total of 1030 patients including 435 seronegative cases were classified as early RA in 1997-2005 at Jyväskylä Rheumatology Centre and prospectively scheduled for a ten-year follow-up. Clinical data from the follow-up visits and the case-reports until and including the 10-year visit or death, whichever happened earlier, were retrospectively collected and reviewed with re-classification of the cases when applicable. Read More

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June 2018
8 Reads

Synovial fluid uric acid level aids diagnosis of gout.

Biomed Rep 2018 Jul 14;9(1):60-64. Epub 2018 May 14.

Department of Rheumatology, Bangabandhu Sheikh Mujib Medical University, Shahbag, Dhaka-1000, Bangladesh.

Examination of urate crystal in synovial fluid (SF) remains the gold standard for diagnosis of gout, but is not universally available. SF uric acid (UA) level may be measured by the uricase method with an automated analyzer. The present study aimed to evaluate the utility of SF to serum UA ratio (SSR) for diagnosis of gout. Read More

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http://dx.doi.org/10.3892/br.2018.1097DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6007039PMC
July 2018
14 Reads

Systematic Overview of Solid Particles and Their Host Responses.

Authors:
Fei Shu Yan Shi

Front Immunol 2018 28;9:1157. Epub 2018 May 28.

Department of Basic Medical Sciences, Institute for Immunology, Center for Life Sciences, Beijing Key Laboratory for Immunological Research on Chronic Diseases, Tsinghua University, Beijing, China.

Crystalline/particulate substances trigger a plethora of signaling events in host cells. The most prominent consequence is the inflammatory reactions that underlie crystal arthropathies, such as gout and pseudogout. However, their impact on our health was underestimated. Read More

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http://dx.doi.org/10.3389/fimmu.2018.01157DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5985299PMC
May 2018
2 Reads

Emergent nanotherapies in microcrystal-induced arthritis.

Int Immunopharmacol 2018 Aug 8;61:197-203. Epub 2018 Jun 8.

Laboratorio de Líquido Sinovial, Instituto Nacional de Rehabilitación "Luis Guillermo Ibarra-Ibarra (INR-LGII), Calz. México-Xochimilco No. 289, Col. Arenal de Guadalupe, Delegación Tlalpan, C.P. 14389 Ciudad de México, Mexico.

The anti-inflammatory and immunomodulatory effects of nanoparticles in several chronic diseases have been extensively researched. The aim of this review is to examine how nanoparticles modulate the inflammatory pathways that characterize the most prevalent forms of microcrystal-induced arthritis, including gout, pseudogout, and BCP-induced arthritis. The nanoparticles of chitosan-coated calcium phosphate, uricase, aceclofenac, and gold have been investigated in crystal-inducedarthritis. Read More

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http://dx.doi.org/10.1016/j.intimp.2018.06.007DOI Listing
August 2018
20 Reads

Diagnosis and Treatment of Gout and Pseudogout for Everyday Practice.

Prim Care 2018 Jun;45(2):213-236

San Antonio Uniformed Services Health Consortium, Department of Rheumatology, 3851 Roger Brooke Drive, San Antonio, TX 78234, USA.

Gout and pseudogout are crystalline arthropathies commonly seen in primary care. It is important to understand their pathophysiology to facilitate recognition and appropriate treatment. Prompt gouty arthritis treatment relieves short-term suffering. Read More

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http://dx.doi.org/10.1016/j.pop.2018.02.004DOI Listing
June 2018
8 Reads

Acute arthritis: predictive factors and current practice in the approach to diagnosis and management across two hospitals in Sydney.

Intern Med J 2018 09;48(9):1087-1095

Department of Rheumatology, Westmead Hospital, Sydney, New South Wales, Australia.

Background: Literature pertaining to the predictive factors for septic arthritis is limited.

Aims: The primary objective was to investigate the predictive factors for septic arthritis. The secondary objectives were to investigate the predictive factors for crystal arthritis and to explore current practices in the management of acute arthritis. Read More

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http://dx.doi.org/10.1111/imj.13969DOI Listing
September 2018

Coexisting Gout and Chondrocalcinosis on Hand Radiograph.

J Rheumatol 2018 May;45(5):723-724

Department of Rheumatology, University Teaching Hospital, Besançon, France. Ethics approval for this case report was not required in accordance with the policy of the authors' institution.

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http://dx.doi.org/10.3899/jrheum.171154DOI Listing
May 2018
17 Reads

Therapy for CPPD: Options and Evidence.

Curr Rheumatol Rep 2018 Apr 19;20(6):31. Epub 2018 Apr 19.

Instituto de Investigación Sanitaria y Biomédica de Alicante (ISABIAL), Universidad Miguel Hernández, Alicante, Spain.

Purpose Of Review: Current evidence and accumulated experience for the management of calcium pyrophosphate deposition disease (CPPD) are presented.

Recent Findings: Contrary to other rheumatic inflammatory conditions that account for high interest and growing research, advances in treating CPPD are still very limited and mostly derive from those achieved in gout. Once formed, calcium pyrophosphate crystals cannot be dissolved; therefore, management relies on the control of crystal-derived inflammation. Read More

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http://dx.doi.org/10.1007/s11926-018-0739-zDOI Listing
April 2018
13 Reads

Diagnosis of pseudo-gout (calcium pyrophosphate deposition disease) clinched on cytology.

Diagn Cytopathol 2018 Sep 11;46(9):748-751. Epub 2018 Apr 11.

Department of Pathology, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India.

Calcium pyrophosphate dihydrate (CPPD) deposition disease is a metabolic arthropathy which results from deposition of calcium pyrophosphate crystals in and around joints especially the hyaline cartilage and disc material. This metabolic disease in uncommon in the smaller joints and multiple diagnostic modalities along with biochemical investigations would be necessary for definite diagnosis. We highlight the case of a 48 year old male who presented with a painful mass at the base of left thumb and was clinic-radiologically suspected as malignancy. Read More

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http://dx.doi.org/10.1002/dc.23939DOI Listing
September 2018
6 Reads

Maltese cross interpretation. Comment on: "Acute phospholipid microspherule associated arthritis: Is it rare?" by Coiffier et al., Joint Bone Spine 2017;84;537-40.

Authors:
Bruce Rothschild

Joint Bone Spine 2018 May 23;85(3):391. Epub 2018 Feb 23.

West Virginia University School of Medicine, 1, Medical center DR, Morgantown, WV 26501, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jbspin.2018.02.003DOI Listing
May 2018
3 Reads

Differential diagnostic perspectives provided by en face microscopic examination of articular surface defects.

Clin Rheumatol 2018 Mar 4;37(3):831-836. Epub 2018 Feb 4.

Department of Vertebrate Paleontology, Carnegie Museum, Pittsburgh, PA, 15213, USA.

Surface defects have a central position in diagnosis of articular pathology. Recognizing the limitations of standard radiologic techniques and those imposed by positioning and averaging artifacts on CT evaluation, direct visualization of surface defects was pursued to identify disease characteristics that would facilitate interpretation of radiologic findings. Epi-illumination surface microscopy was utilized to examine macroscopically recognized articular surface defects in individuals in the Hamann-Todd, Terry, and Huntington human skeletal collections with previously verified diagnoses of rheumatoid arthritis, spondyloarthropathy, juvenile inflammatory arthritis (JIA), calcium pyrophosphate deposition disease (CPPD), gout, metastatic cancer, multiple myeloma, septic arthritis, tuberculosis, fungal arthritis, histiocytosis and sickle cell anemia (Rothschild and Rothschild Clin Infect Dis 20(5):1402-1408, 1995; Rothschild et al. Read More

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http://dx.doi.org/10.1007/s10067-018-4001-xDOI Listing
March 2018
11 Reads

Intraarticular calcifying aponeurotic fibroma of the wrist: mimicking gout or calcium pyrophosphate dihydrate deposition disease.

Skeletal Radiol 2018 May 14;47(5):729-734. Epub 2017 Dec 14.

Department of Radiology, CHA Bundang Medical Center, College of Medicine, CHA University, 59, Yatap-ro, Bundang-gu, Seongnam-si, Gyeonggi-do, 13496, Republic of Korea.

Calcifying aponeurotic fibroma is a rare, benign fibroblastic tumor that typically occurs in the palms of the hands and soles of the feet in children and adolescents. We report an unusual case of a calcifying aponeurotic fibroma with diffuse intra-articular involvement of the carpal joints in a 59-year-old female. Radiographs and computed tomography scans revealed a large lobulated soft tissue mass with multiple stippled calcifications around the carpal joints and numerous erosions of the second to fifth carpometacarpal and intercarpal joints. Read More

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http://link.springer.com/10.1007/s00256-017-2847-7
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http://dx.doi.org/10.1007/s00256-017-2847-7DOI Listing
May 2018
15 Reads

An investigation of the independent risk factors that differentiate gout from pseudogout in patients with crystal-induced acute arthritis: a cross-sectional study.

Rheumatol Int 2018 Jan 6;38(1):89-95. Epub 2017 Dec 6.

Division of Rheumatology, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, 2 Wanglang Road, Bangkoknoi, Bangkok, 10700, Thailand.

Objectives: To identify independent risk factors that differentiate gout from pseudogout in patients that present with crystal-induced acute arthritis.

Methods: This cross-sectional study was conducted at Siriraj Hospital (Bangkok, Thailand) during the 25 May 2014-28 November 2014 study period. Patients who presented with crystal-induced acute arthritis were eligible for inclusion. Read More

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http://dx.doi.org/10.1007/s00296-017-3891-2DOI Listing
January 2018
12 Reads

Wrist inflammation: a retrospective comparison between septic and non-septic arthritis.

J Hand Surg Eur Vol 2018 May 3;43(4):431-437. Epub 2017 Dec 3.

Singapore General Hospital, Singapore.

This study aims to identify differences in demographics, clinical and laboratory data between wrist septic arthritis and non-septic arthritis in patients admitted for wrist inflammation. A retrospective review of inpatients from May 2012 to April 2015 was conducted. Seventy-seven patients were included. Read More

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http://dx.doi.org/10.1177/1753193417738166DOI Listing
May 2018
14 Reads

Crystalline arthropathy and bone health.

Curr Opin Rheumatol 2018 03;30(2):173-176

Division of Rheumatology, Department of Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.

Purpose Of Review: The purpose of this review is to provide insight on the proposed association between crystal arthritis and bone health. Crystal arthritis is the most common type of inflammatory arthritis, and fractures contribute to significant morbidity and mortality, therefore, the relationship between the two is of clinical importance.

Recent Findings: There have been variable findings regarding hyperuricemia, low bone density and risk of fracture. Read More

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http://dx.doi.org/10.1097/BOR.0000000000000469DOI Listing
March 2018
7 Reads

Nonrheumatoid Arthritis of the Hand.

J Hand Surg Am 2018 01 11;43(1):61-67. Epub 2017 Nov 11.

Department of Orthopedic Surgery, Hand and Upper Extremity Service, Massachusetts General Hospital, Harvard Medical School, Boston, MA.

Arthropathy of the hand is commonly encountered. Contributing factors such as aging, trauma, and systemic illness all may have a role in the evolution of this pathology. Besides rheumatoid arthritis, other diseases affect the small joints of the hand. Read More

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http://dx.doi.org/10.1016/j.jhsa.2017.10.021DOI Listing
January 2018
14 Reads

Calcium pyrophosphate deposition disease: a frequent finding in patients with long-standing erosive gout.

Scand J Rheumatol 2018 Mar 16;47(2):127-130. Epub 2017 Aug 16.

a Department of Rheumatology , University Hospital Basel , Basel , Switzerland.

Objective: To characterize patients with both monosodium urate (MSU) and calcium pyrophosphate (CPP) crystals in their synovial fluid (SF).

Method: Forty-nine gout patients with acute arthritis were included. Those patients with MSU crystals only in their SF were compared to those patients with both MSU and CPP crystals in their SF. Read More

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http://dx.doi.org/10.1080/03009742.2017.1332239DOI Listing
March 2018
4 Reads

[Contemporary use of radiosynoviorthesis in chronic polyarthrtitis].

Wiad Lek 2017;70(3 pt 2):677-684

Klinika Reumatologii I Układowych Chorób Tkanki Łącznej, Uniwersytet Medyczny, Lublin, Polska.

Radiosynoviorthesis is used for local treatment of recurrent joint effusions, leads to necrosis of inflamed synovium due to beta radiation energy served after intraarticular radionuclide administration. The aim of the therapy is destruction and fibrosis of abnormal, hypertrophic synovial membrane and then full recovery of its normal function after local corticosteroids and systemic modifying drugs failure. Radiosynoviorthesis is effective in different type of peripheral arthritis like rheumatoid arthritis, inflammatory spondyloarthtropaties, gout, chondrocalcinosis, pigmented villo-nodular synovitis, recurrent knee effusion after total joint replacement, idiopathic knee joint effusion, osteoarthritis and secondary prevention of intraarticular bleeding in haemophilia. Read More

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October 2018
12 Reads

The value of musculoskeletal ultrasound in geriatric care and rehabilitation.

Int J Rehabil Res 2017 Dec;40(4):285-296

aDepartment of Internal Medicine, Gazi University Medical School, Division of Geriatrics bDepartment of Physical and Rehabilitation Medicine, Hacettepe University Medical School, Ankara, Turkey cDepartment of Physical Medicine, Rehabilitation, and Sports Medicine, Nashville, Tennessee dDepartment of Physiology and Biophysics University of Puerto Rico School of Medicine, San Juan, Puerto Rico, USA.

The WHO reports that one of the major chronic conditions affecting the elderly worldwide is musculoskeletal disorders that are associated with long-term pain and disability. Considering the healthcare needs of the elderly (i.e. Read More

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http://dx.doi.org/10.1097/MRR.0000000000000239DOI Listing
December 2017
78 Reads

ACR Appropriateness Criteria Chronic Extremity Joint Pain-Suspected Inflammatory Arthritis.

J Am Coll Radiol 2017 May;14(5S):S81-S89

Specialty Chair, Brigham & Women's Hospital, Boston, Massachusetts.

Evaluation for suspected inflammatory arthritis as a cause for chronic extremity joint pain often relies on imaging. This review first discusses the characteristic osseous and soft tissue abnormalities seen with inflammatory arthritis and how they may be imaged. It is essential that imaging results are interpreted in the context of clinical and serologic results to add specificity as there is significant overlap of imaging findings among the various types of arthritis. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15461440173018
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http://dx.doi.org/10.1016/j.jacr.2017.02.006DOI Listing
May 2017
19 Reads

Milwaukee Shoulder Syndrome.

J Surg Orthop Adv 2017 ;26(1):54-57

ProScan Imaging Education Foundation, Cincinnati, Ohio.

Milwaukee shoulder syndrome (MSS) is a rare, rapidly destructive arthropathy associated with calcium hydroxyapatite crystal deposition. This condition is a combination of rotator cuff tear, osteoarthritic changes, noninflammatory joint effusion containing crystals, synovial hyperplasia, cartilage and subchondral bone destruction, and multiple osteochondral loose bodies. This article discusses pathophysiology, clinical presentation, differential considerations, and magnetic resonance imaging findings of MSS. Read More

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July 2017
8 Reads

The added value of synovial fluid centrifugation for monosodium urate and calcium pyrophosphate crystal detection.

Clin Rheumatol 2017 Jul 19;36(7):1599-1605. Epub 2017 Apr 19.

Arthritis Centre Twente at Medisch Spectrum Twente, Enschede, The Netherlands.

The aim of the study was to assess the added value of synovial fluid (SF) centrifugation for microscopic monosodium urate (MSU) and calcium pyrophosphate (CPP) crystal detection in patients with arthritis. This is a prospective observational study using SF samples from joints of patients undergoing joint arthrocentesis. Two blinded observers assessed the SF smears by polarized light microscopy for the presence of crystals before as well as after centrifugation. Read More

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http://dx.doi.org/10.1007/s10067-017-3633-6DOI Listing
July 2017
8 Reads

Adverse reaction to metal debris with concomitant incidental crystalline arthropathy in hip arthroplasty.

Arthroplast Today 2017 Mar 1;3(1):19-23. Epub 2016 Dec 1.

Tufts University School of Medicine, Boston, MA, USA; Division of Joint Replacement Surgery, Maine Medical Center and Maine Joint Replacement Institute, Portland, ME, USA.

Adverse reaction to metal debris (ARMD) is a known cause of failed metal in hip arthroplasty. Diagnosis of this type of prosthesis failure may be difficult, and the hallmark is an abnormally elevated serum cobalt level. Concomitant diagnoses may also be present, such as infection, instability, and loosening, and this may confuse interpretation of abnormal laboratories. Read More

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http://dx.doi.org/10.1016/j.artd.2016.10.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5365402PMC
March 2017
6 Reads

Neutrophil Extracellular Traps and Microcrystals.

Authors:
Balázs Rada

J Immunol Res 2017 7;2017:2896380. Epub 2017 Mar 7.

College of Veterinary Medicine, Department of Infectious Diseases, The University of Georgia, Athens, GA, USA.

Neutrophil extracellular traps represent a fascinating mechanism by which PMNs entrap extracellular microbes. The primary purpose of this innate immune mechanism is thought to localize the infection at an early stage. Interestingly, the ability of different microcrystals to induce NET formation has been recently described. Read More

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http://dx.doi.org/10.1155/2017/2896380DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5361057PMC
May 2017
9 Reads

Monoarticular Arthritis.

Med Clin North Am 2017 May 2;101(3):607-613. Epub 2017 Mar 2.

Division of Immunology: Rheumatology and Allergy, Department of Internal Medicine, University of Iowa Carver College of Medicine, 200 Hawkins Drive, C 42 GH, Iowa City, IA 52242, USA; Division of Immunology: Rheumatology and Allergy, Department of Internal Medicine, University of Iowa Carver College of Medicine, 200 Hawkins Drive, C 42 GH, Iowa City, IA 52242, USA. Electronic address:

Monoarticular arthritis is inflammation characterized by joint pain, swelling, and sometimes periarticular erythema. Although chronic causes are seen, the onset is often acute. An infected joint can quickly lead to permanent damage, making it a medical emergency. Read More

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http://dx.doi.org/10.1016/j.mcna.2016.12.004DOI Listing
May 2017
10 Reads

Crystal arthritides - gout and calcium pyrophosphate arthritis : Part 1: Epidemiology and pathophysiology.

Z Gerontol Geriatr 2018 Jun 23;51(4):453-460. Epub 2017 Feb 23.

Klinik für Rheumatologie, Klinische Immunologie und Physikalische Therapie, Zentrum für Rheumatologische Akutdiagnostik, Katholisches Klinikum Mainz, Standort St. Vincenz und Elisabeth Hospital, An der Goldgrube 11, 55131, Mainz, Germany.

Gout and calcium pyrophosphate deposition disease (CPPD, pseudogout) are still the most frequent inflammatory arthritides in multimorbid elderly patients. Gout and CPPD are different diseases and based on different pathophysiological principles. Gout is closely associated with the metabolic syndrome and is an independent risk factor for cardiovascular mortality. Read More

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http://link.springer.com/10.1007/s00391-017-1197-3
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http://dx.doi.org/10.1007/s00391-017-1197-3DOI Listing
June 2018
5 Reads

Acute phospholipid microspherule associated arthritis: Is it rare?

Joint Bone Spine 2017 Oct 15;84(5):537-540. Epub 2016 Dec 15.

Service de Rhumatologie, CHU de Rennes, Hôpital Sud, 16, boulevard de Bulgarie, BP 90347, 35203 Rennes cedex 2, France; INSERM UMR 991, 35043 Rennes, France; Université Rennes 1, Faculté de médecine, 35043 Rennes, France.

Joint fluid analysis must be performed as part of the diagnostic workup for acute arthritis, most notably to rule out septic arthritis and to allow the identification of crystal-induced arthritis (gout or calcium pyrophosphate deposition disease), which is one of the most common causes. However, the detection of monosodium urate or calcium pyrophosphate microcrystals is not the only goal of the polarized light microscopy examination of joint fluid. Other, less common microcrystals may be found. Read More

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http://dx.doi.org/10.1016/j.jbspin.2016.11.001DOI Listing
October 2017
5 Reads

Systematic review and quality analysis of emerging diagnostic measures for calcium pyrophosphate crystal deposition disease.

RMD Open 2016 3;2(2):e000339. Epub 2016 Nov 3.

Department of Rheumatology , VAMC/UCSD , San Diego, California , USA.

Objectives: Calcium pyrophosphate crystal deposition disease (CPPD) is common, yet prevalence and overall clinical impact remain unclear. Sensitivity and specificity of CPPD reference standards (conventional crystal analysis (CCA) and radiography (CR)) were meta-analysed by EULAR (published 2011). Since then, new diagnostic modalities are emerging. Read More

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http://dx.doi.org/10.1136/rmdopen-2016-000339DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5133413PMC
November 2016
9 Reads

Calcium Pyrophosphate Dihydrate Deposition Disease in Young Patients: Two Case Reports.

Arch Rheumatol 2017 Mar 8;32(1):80-83. Epub 2016 Dec 8.

Department of Rheumatology, District General Hospital, Nuwara Eliya, Nuwara Eliya, Sri Lanka.

Calcium pyrophosphate deposition disease (CPDD) is a type of arthritis caused by the deposition of calcium pyrophosphate crystals, and may present as either acute or chronic arthritis. Development of CPPD crystal deposition disease in young people may be associated with metabolic diseases such as hemochromatosis, hyperparathyroidism, hypomagnesemia, Wilson's disease, hypothyroidism, gout, acromegaly, and X-linked hypophosphatemic rickets. Therefore, investigations for a predisposing metabolic condition are advised in young-onset polyarticular CPPD crystal deposition disease. Read More

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http://www.archivesofrheumatology.org/full-text/832
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http://dx.doi.org/10.5606/ArchRheumatol.2017.6015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6190932PMC
March 2017
3 Reads

[Differential diagnosis of monoarthritis].

Cas Lek Cesk Fall 2016;155(6):299-304

Making the diagnosis of monoarthritis can be quite difficult, because in contrast with polyarthritis just a few clinical data is available and wide diagnostic spectrum is present.The diagnosis of inflammatory rheumatic disease is usually in responsibility of a rheumatologist, but we know from experience that is necessary to carry out the basal differential diagnostic assessment as soon as possible to begin the optimal therapy. General practitioners and orthopaedists are usually first to face this problem. Read More

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June 2017
9 Reads

Calcium Pyrophosphate Deposition Disease and Associated Medical Comorbidities: A National Cross-Sectional Study of US Veterans.

Arthritis Care Res (Hoboken) 2017 09 8;69(9):1400-1406. Epub 2017 Aug 8.

University of Wisconsin and the William S. Middleton VA Medical Center, Madison, Wisconsin.

Objective: Calcium pyrophosphate deposition disease (CPDD) is a common cause of acute and chronic arthritis, yet there are few large epidemiologic studies of CPDD. We sought to characterize CPDD in the national Veterans Affairs (VA) population.

Methods: Using data from the Department of VA Corporate Data Warehouse, patients with International Classification of Diseases, Ninth Revision, codes for CPDD seen at any VA medical center from 2010 through 2014 were matched by age and sex with control patients without CPDD. Read More

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http://dx.doi.org/10.1002/acr.23160DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5472491PMC
September 2017
31 Reads

Crowned dens syndrome developed after an endoscopic retrograde cholangiopancreatography procedure.

World J Gastroenterol 2016 Oct;22(39):8849-8852

Hiroyasu Nakano, Kazunari Nakahara, Yosuke Michikawa, Keigo Suetani, Ryo Morita, Nobuyuki Matsumoto, Fumio Itoh, Division of Gastroenterology and Hepatology, Department of Internal Medicine, St. Marianna University School of Medicine, Kanagawa 216-8511, Japan.

We present a unique case of crowned dens syndrome (CDS) that developed after endoscopic retrograde cholangiopancreatography (ERCP) in a patient who presented with fever and neck pain. Administration of non-steroidal anti-inflammatory drugs was extremely effective for relieving fever and neck pain, and in the improvement of inflammatory markers. To the best of our knowledge, this is the first case report of CDS caused by an ERCP procedure. Read More

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http://dx.doi.org/10.3748/wjg.v22.i39.8849DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5075560PMC
October 2016
4 Reads

Unusual Electromyographic Findings Associated With Colchicine Neuromyopathy: A Case Report.

PM R 2016 10 10;8(10):1016-1019. Epub 2016 Mar 10.

Departments of Physical Medicine and Rehabilitation and Neurology, Chicago, IL.

An 83-year-old man with multiple medical problems, including gout, pseudogout, and renal insufficiency, presented with more than a year of proximal weakness. He had an extensive previous medical workup, including a normal creatinine kinase. His weakness persisted despite endurance and strength training. Read More

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http://dx.doi.org/10.1016/j.pmrj.2016.03.003DOI Listing
October 2016
8 Reads

Imaging in Gout and Other Crystal-Related Arthropathies.

Rheum Dis Clin North Am 2016 11 9;42(4):621-644. Epub 2016 Sep 9.

Department of Rheumatology, Lausanne University Hospital, Av Pierre Decker 5, Lausanne 1011, Switzerland.

In this article, the authors consider the manifestations of intraarticular and periarticular crystal deposits. Most cases of crystal deposits are asymptomatic and represent incidental findings at imaging. In symptomatic arthropathies, imaging can play an important role in the diagnosis and assessment of disease progression and the extent of crystal deposits. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0889857X163004
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http://dx.doi.org/10.1016/j.rdc.2016.07.005DOI Listing
November 2016
14 Reads

Jolt accentuation of neck pain: a novel physical finding for crowned dens syndrome.

BMJ Case Rep 2016 Oct 12;2016. Epub 2016 Oct 12.

Department of General Internal Medicine, Tsukuba University, Mito, Ibaraki, Japan.

Crowned dens syndrome (CDS), a pseudogout attack involved with atlantoaxial joint, mimics meningitis, because jolt accentuation of headache, a physical sign for meningitis, is frequently considered mistakenly as 'positive' in CDS patients. Our patient with CDS experienced multiple ambulance transports and underwent lumbar puncture for suspected meningitis because of positive result of jolt accentuation of headache. We found that the patient actually had jolt accentuation of neck pain from CDS and treated her successfully. Read More

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http://dx.doi.org/10.1136/bcr-2016-217128DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5073716PMC
October 2016
5 Reads

MUSCULOSKELETAL IMPAIRMENT IN PRYMARY HYPOTHYROIDISM.

Rev Med Chir Soc Med Nat Iasi 2016 Apr-Jun;120(2):244-51

This article contains bibliographical data concerning the rheumatic clinical manifestations in hypothyroidism: polyarthralgias, lack of recent skill of fine movements of the hands, carpal tunnel syndrome or tarsal, degenerative arthropathy or acute type (gout, chondrocalcinosis), adhesive capsulitis (frozen shoulder syndrome), generalized muscular stiffness, hypothyroid myopathy, secondary osteoarthritis, Dupuytren's contracture, "trigger finger" (also called as stenosing tenosynovitis or trigger thumb) etc. and data on the short history, epidemiology, of these disorders. Review include 60 bibliographical sources. Read More

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October 2016
8 Reads

Calcium Pyrophosphate Dihydrate Deposition Disease in a Knee With Total Joint Replacement.

J Clin Rheumatol 2016 Aug;22(5):277

From the *Arthritis & Rheumatology Associates of South Jersey, PC, Vineland; and †Rothman Institute, Egg Harbor Township, NJ.

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http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:land
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http://dx.doi.org/10.1097/RHU.0000000000000384DOI Listing
August 2016
3 Reads