667 results match your criteria Gout and Pseudogout


White blood cell count and total protein concentration to predict the absence of microcrystals in synovial fluid.

Clin Biochem 2020 May 26. Epub 2020 May 26.

Clinical Laboratory. Emergency Department. Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí I3PT. Universitat Autònoma de Barcelona. Sabadell, Spain.

Background: Synovial fluid analysis is essential for diagnosing crystal-induced arthritis. Monosodium urate monohydrate (MSU) crystals in gout and calcium pyrophosphate dihydrate (CPP) crystals in pseudogout trigger inflammatory reactions that result in white blood cell (WBC) activation. This study aimed to evaluate the predictive value of synovial fluid WBC count and total protein concentration for the absence of microcrystals. Read More

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http://dx.doi.org/10.1016/j.clinbiochem.2020.05.010DOI Listing

Cartilage icing and chondrocalcinosis on knee radiographs in the differentiation between gout and calcium pyrophosphate deposition.

PLoS One 2020 16;15(4):e0231508. Epub 2020 Apr 16.

Department of Rheumatology, University of Rochester, Rochester, New York, United States of America.

Objective: To determine if findings of "cartilage icing" and chondrocalcinosis on knee radiography can differentiate between gout and calcium pyrophosphate deposition (CPPD).

Methods: IRB-approval was obtained and informed consent was waived for this retrospective study. Electronic medical records from over 2. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0231508PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7162505PMC

Pseudogout Mimicking Aortic Dissection: A Case Report.

Cureus 2019 Nov 26;11(11):e6239. Epub 2019 Nov 26.

Emergency Medicine, Thomas Jefferson University Hospital, Philadelphia, USA.

Calcium pyrophosphate dihydrate (CPPD) crystal deposition disease or pseudogout is an idiopathic articular disease that predominantly affects elderly patients. It is caused by a systemic deposition of calcium pyrophosphate (CPP) crystals in the articular and hyaline joint cartilage. The majority of cases present as chronic arthritis, but a subset of CPPD can present as rapid onset of sharp pain and joint swelling, posing a diagnostic challenge. Read More

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http://dx.doi.org/10.7759/cureus.6239DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6935328PMC
November 2019

Prevalence and incidence of non-gout crystal arthropathy in southern Sweden.

Arthritis Res Ther 2019 12 17;21(1):291. Epub 2019 Dec 17.

Department of Clinical Sciences, Lund, Section for Rheumatology, Lund University, Lund and Skåne University Hospital, Lund, Sweden.

Objective: To estimate the prevalence and incidence of non-gout crystal arthropathy in relation to socioeconomic factors in southern Sweden.

Methods: All patients (age ≥ 18 years) with at least one visit to a physician with the diagnosis of interest in the Skåne region (population of 1.3 million) in 1998-2014 were identified. Read More

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http://dx.doi.org/10.1186/s13075-019-2077-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6918617PMC
December 2019

Dual-energy CT in the differentiation of crystal depositions of the wrist: does it have added value?

Skeletal Radiol 2020 May 4;49(5):707-713. Epub 2019 Dec 4.

Department of Radiology, Charité - Universitätsmedizin Berlin, Berlin, Germany.

Objectives: To evaluate the ability of dual-energy computed tomography (DECT) to improve diagnostic discrimination between gout and other crystal arthropathies such as calcium pyrophosphate deposition disease (CPPD) of the wrist in a clinical patient population.

Materials And Methods: This retrospective case-control study included 29 patients with either gout (case group; n = 9) or CPPD (control group; n = 20) who underwent DECT of the wrist for clinically suspected crystal arthropathy. Color-coded urate and enhanced calcium as well as virtual 120 kVe blended images were reconstructed from the DECT datasets. Read More

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http://dx.doi.org/10.1007/s00256-019-03343-5DOI Listing

Heterotopic ossification: radiological and pathological review.

Radiol Oncol 2019 09 24;53(3):275-284. Epub 2019 Sep 24.

Department of Diagnostic Imaging, University of Texas MD Anderson Cancer Center, Houston, USA.

Background Heterotopic Ossification (HO) is a common condition referring to ectopic bone formation in soft tissues. It has two major etiologies, acquired (more common) and genetic. The acquired form is closely related to tissue trauma. Read More

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http://dx.doi.org/10.2478/raon-2019-0039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6765162PMC
September 2019
1 Read

[Chondrocalcinosis: idiopathic or manifestation of rare metabolic diseases?]

Orthopade 2019 Nov;48(11):949-956

Medizinische Klinik 3 - Rheumatologie und Immunologie, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Ulmenweg 18, 91054, Erlangen, Deutschland.

Calcification in hyaline and fibrocartilage is caused by the deposition of calcium pyrophosphate dehydrate, commonly referred to as chondrocalcinosis. Clinically, this can lead to arthritis symptoms similar to a gout attack -"pseudogout". Nonetheless, also chronic or asymptomatic disease courses are possible. Read More

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http://dx.doi.org/10.1007/s00132-019-03805-7DOI Listing
November 2019
7 Reads

Nanostructured TiO Materials for Analysis of Gout-Related Crystals Using Laser Desorption/Ionization Time-of-Flight (LDI-ToF) Mass Spectrometry.

Anal Chem 2019 09 12;91(17):11283-11290. Epub 2019 Aug 12.

Department of Materials Science and Engineering , Yonsei University , 134 Shinchon-dong , Seodaemun-gu, Seoul 03722 , Korea.

Crystals of monosodium urate monohydrate (MSU) and calcium pyrophosphate dihydrate (CPPD) are known to induce arthropathic diseases called gout and pseudogout, respectively. These crystals are deposited in various joints or tissues, causing severe pain. Correct identification of crystals is crucial for the appropriate treatment of gout and pseudogout, which exhibit very similar symptoms. Read More

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https://pubs.acs.org/doi/10.1021/acs.analchem.9b02231
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http://dx.doi.org/10.1021/acs.analchem.9b02231DOI Listing
September 2019
4 Reads

Monosodium urate deposition in the articular cartilage and meniscus can mimic chondrocalcinosis.

Joint Bone Spine 2020 Jan 17;87(1):95-96. Epub 2019 Jul 17.

Service de rhumatologie, hôpital Lariboisière, AP-HP, 2, rue Ambroise Paré, 75010 Paris, France; Inserm U1132, université Paris-Diderot, 75010 Paris, France.

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http://dx.doi.org/10.1016/j.jbspin.2019.06.014DOI Listing
January 2020
4 Reads

Dual-energy computed tomography in calcium pyrophosphate deposition: initial clinical experience.

Osteoarthritis Cartilage 2019 09 27;27(9):1309-1314. Epub 2019 May 27.

EA 4490, PMOI, Physiopathologie des Maladies Osseuses Inflammatoires, University of Lille, Lille, France; Department of Diagnostic and Interventional Radiology, Lille Catholic Hospitals, University of Lille, Lomme, France. Electronic address:

Objective: To determine the dual-energy computed tomography (DECT) attenuation properties of meniscal calcifications in calcium pyrophosphate deposition (CPPD) in vivo, and assess whether DECT was able to discriminate meniscal CPP deposits from calcium hydroxyapatite (HA) in subchondral and trabecular bone.

Method: Patients with clinical suspicion of crystal-related arthropathy (gout and/or CPPD) and knee DECT scans were retrospectively assigned to CPPD (n = 19) or control (n = 21) groups depending on the presence/absence of chondrocalcinosis on DECT. Two observers drew standardized regions of interest (ROI) in meniscal calcifications, non-calcified menisci, as well as subchondral and trabecular bone. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10634584193100
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http://dx.doi.org/10.1016/j.joca.2019.05.007DOI Listing
September 2019
14 Reads

Hand Infections.

Clin Plast Surg 2019 Jul;46(3):371-381

The University of Michigan Health System, 1500 East Medical Center Drive, 2130 Taubman Center, SPC 5340, Ann Arbor, MI 48109-5340, USA.

Hand infections can lead to debilitating and permanent disability, particularly if they are not treated promptly or properly. The unique anatomy of the hand, with its numerous enclosed and confined spaces, warrants special considerations. For instance, infections in deep spaces of the hand may require surgical drainage despite an appropriate course of antimicrobial treatment. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00941298193002
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http://dx.doi.org/10.1016/j.cps.2019.03.003DOI Listing
July 2019
30 Reads

Crowned dens syndrome presenting as pyrexia of unknown origin (PUO).

Rom J Intern Med 2019 Sep;57(3):266-269

Department of Internal Medicine, Cleveland Clinic Ohio, USA.

Background: Deposition of calcium pyrophosphate crystals in the cervical spine around the odontoid process may lead to neck pain and fever. This condition is called crowned dens syndrome (CDS).

Case Report: An 89-year-old female presented with complaints of fever for one-month duration and recent onset neck pain. Read More

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https://content.sciendo.com/view/journals/rjim/ahead-of-prin
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http://dx.doi.org/10.2478/rjim-2019-0011DOI Listing
September 2019
27 Reads

Consistency of the Sonographic Image (Double Contour Sign) in Patients with Gout after Ambulation.

Authors:
Angel Checa

J Med Ultrasound 2019 Jan-Mar;27(1):40-42. Epub 2019 Jan 8.

Lourdes Medical Center of Burlington County, Endoscopy Unit, Willingboro, New Jersey, USA.

The aim of this study was to know whether or not any crystal shedding occurs after ambulation in patients with gout and how it affects the consistency of the sonographic image of crystal deposition on hyaline cartilage. A total of 18 consecutive patients (29 knees), 11 with early gout (17 knees) and seven with chondrocalcinosis (12 knees), were prospectively scanned by ultrasound. Examination at rest and after ambulation was performed in each patient. Read More

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http://dx.doi.org/10.4103/JMU.JMU_77_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6445031PMC
January 2019
11 Reads

Adsorption of Proteins on m-CPPD and Urate Crystals Inhibits Crystal-induced Cell Responses: Study on Albumin-crystal Interaction.

J Funct Biomater 2019 Apr 25;10(2). Epub 2019 Apr 25.

CIRIMAT, Université de Toulouse, CNRS, Université Toulouse 3, Toulouse INP - ENSIACET, Toulouse 31030, France.

The biological effects and cellular activations triggered by monosodium urate (MSU) and calcium pyrophosphate dihydrate (monoclinic: m-CPPD) crystals might be modulated by protein coating on the crystal surface. This study is aimed at: (i) Identifying proteins adsorbed on m-CPPD crystals, and the underlying mechanisms of protein adsorption, and (ii) to understand how protein coating did modulate the inflammatory properties of m-CPPD crystals. The effects of protein coating were assessed in vitro using primary macrophages and THP1 monocytes. Read More

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http://dx.doi.org/10.3390/jfb10020018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6616386PMC
April 2019
10 Reads

A Rare Case of Gout and Pseudogout Occurring in the Same Joint.

Authors:
Y H Wang Swl Ho

Malays Orthop J 2019 Mar;13(1):54-56

Department of Orthopaedic Surgery, Tan Tock Seng Hospital, Singapore.

Pseudogout and gout are common types of inflammatory joint disease in the elderly. However, the existence of both in a single joint in a patient is relatively rare. This case report describes an interesting case of a 42-year old man who presented with simultaneous gout and pseudogout in the knee joint, diagnosed via polarised light microscopy. Read More

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http://www.morthoj.org/2019/v13n1/gout-and-pseudogout.pdf
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http://dx.doi.org/10.5704/MOJ.1903.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6459035PMC
March 2019
9 Reads

Dual-Energy Computed Tomography for the Noninvasive Diagnosis of Coexisting Gout and Calcium Pyrophosphate Deposition Disease.

Arthritis Rheumatol 2019 08 20;71(8):1392. Epub 2019 Jun 20.

Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.

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http://dx.doi.org/10.1002/art.40907DOI Listing
August 2019
7 Reads

Calcium Pyrophosphate Deposition Disease Involving a Lumbar Facet Joint Following Urinary Tract Infection.

Intern Med 2019 Jun 25;58(12):1787-1789. Epub 2019 Feb 25.

Disease Control and Prevention Center, National Center for Global Health and Medicine, Japan.

A 75-year-old woman was admitted with urosepsis due to Escherichia coli infection. After improvement with a ureteral stent and antimicrobial agent, she complained of back pain and showed elevated inflammation marker levels. Arthralgia and arthritis of multiple peripheral joints were noted, and radiography indicated cartilage calcification. Read More

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http://dx.doi.org/10.2169/internalmedicine.2099-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6630135PMC
June 2019
32 Reads

Clinical Presentation, Management, and Prognosis of Pseudogout in Joint Arthroplasty: A Retrospective Cohort Study.

J Bone Jt Infect 2019 1;4(1):20-26. Epub 2019 Jan 1.

Division of Infectious Diseases, Department of Internal Medicine, Mayo Clinic School of Graduate Medical Education. 200 1st St SW, Rochester, MN 55905.

Calcium pyrophosphate deposition disease (CPPD), or pseudogout, is rare in prosthetic joints, but can mimic prosthetic joint infection (PJI) according to case reports. The purpose of this case series is to describe the demographics, presentation, management, and outcomes of a cohort of these patients seen at our academic medical center. Patients with post-implant pseudogout, who were evaluated at our medical center between January 1, 2000 and June 30, 2016, were identified from our EHR. Read More

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http://dx.doi.org/10.7150/jbji.29983DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367192PMC
January 2019
31 Reads

Acute monoarthritis.

Authors:
Jill M Ellis

JAAPA 2019 Mar;32(3):25-31

Jill M. Ellis is an associate professor in the PA program at Grand Valley State University in Grand Rapids, Mich. The author has disclosed no potential conflicts of interest, financial or otherwise.

Acute monoarthritis affects a single joint and has many potential underlying causes, including crystal deposition diseases, infection, trauma, and osteoarthritis. A comprehensive health history and physical examination can help narrow the list of differential diagnoses; judicious diagnostic testing can help pinpoint the diagnosis. Clinicians also must be able to recognize which patients require emergency referral to prevent long-term adverse consequences. Read More

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http://dx.doi.org/10.1097/01.JAA.0000553379.52389.ebDOI Listing
March 2019
15 Reads

Clinical Utility of Multi-Energy Spectral Photon-Counting Computed Tomography in Crystal Arthritis.

Arthritis Rheumatol 2019 07 28;71(7):1158-1162. Epub 2019 May 28.

University of Otago, Christchurch, New Zealand.

Objective: To determine whether novel multi-energy spectral photon-counting computed tomography (SPCCT) imaging can detect and differentiate between monosodium urate (MSU), calcium pyrophosphate (CPP), and hydroxyapatite (HA) crystal deposits ex vivo.

Methods: A finger with a subcutaneous gouty tophus and a calcified knee meniscus excised at the time of surgery were obtained. The finger was imaged using plain x-ray, dual-energy CT (DECT), and multi-energy SPCCT. Read More

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http://doi.wiley.com/10.1002/art.40848
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http://dx.doi.org/10.1002/art.40848DOI Listing
July 2019
60 Reads

Patients Presenting with a Hot, Swollen Joint: A Single-Centre Retrospective Analysis.

Curr Rheumatol Rev 2020 ;16(1):38-42

Division of Trauma & Orthopaedics, Addenbrooke's Hospital, University of Cambridge, Cambridge, CB2 0QQ, United Kingdom.

Background: A hot, swollen joint is a common clinical condition encountered in the ED and elective orthopaedic and rheumatology clinics. These patients can be difficult to manage and properly treat.

Aims And Objectives: The aim of this study was to report a single centre retrospective analysis of patients presenting to our institution for a hot, swollen joint over a three-month period. Read More

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http://dx.doi.org/10.2174/1573397115666190122113659DOI Listing
January 2020
31 Reads

Use of Anakinra in Hospitalized Patients with Crystal-associated Arthritis.

J Rheumatol 2019 10 15;46(10):1345-1349. Epub 2019 Jan 15.

From the Division of Rheumatology, Department of Medicine, University of Washington, Seattle, Washington, USA.

Objective: In this retrospective observational study, we assess the efficacy and safety of the interleukin 1 receptor antagonist anakinra in medically complex, hospitalized patients with acute gout and calcium pyrophosphate crystal arthritis.

Methods: Adult inpatients treated with anakinra from 2014 to 2017 were identified for inclusion. Charts were reviewed for demographics, comorbidities, laboratory data, pain scores, joint involvement, prior treatment, dosing and response to anakinra, concurrent infections, and surgical interventions. Read More

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http://dx.doi.org/10.3899/jrheum.181018DOI Listing
October 2019
2 Reads

Utility of Anakinra in Acute Crystalline Diseases: A Retrospective Study Comparing a University Hospital with a Veterans Affairs Medical Center.

J Rheumatol 2019 07 15;46(7):748-750. Epub 2018 Nov 15.

From the Division of Arthritis and Rheumatic Diseases, Oregon Health & Science University; Rheumatology Section, Veterans Affairs (VA) Portland Health Care System, Portland, Oregon, USA.

Objective: To evaluate the efficacy and safety of anakinra in inpatient management of acute gout and pseudogout.

Methods: Hospitalized patients with acute gout (n = 77) or pseudogout (n = 11) or both (n = 3) were analyzed for response to anakinra and adverse effects.

Results: Half of all patients had comorbidities limiting the treatment choice. Read More

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http://www.jrheum.org/lookup/doi/10.3899/jrheum.180393
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http://dx.doi.org/10.3899/jrheum.180393DOI Listing
July 2019
21 Reads

Coexisting polyarticular septic arthritis, gout and pseudogout.

BMJ Case Rep 2018 Oct 28;2018. Epub 2018 Oct 28.

Infectious Diseases, Blacktown Mount Druitt Hospital, Blacktown, New South Wales, Australia.

A case of a 67-year-old man with coexisting polyarticular septic arthritis due to group G , gout and pseudogout is presented. Septic arthritis of the left knee joint was further complicated by the development of an adjacent osteomyelitis. Appropriate management led to a full clinical recovery. Read More

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http://casereports.bmj.com/lookup/doi/10.1136/bcr-2018-22681
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http://dx.doi.org/10.1136/bcr-2018-226810DOI Listing
October 2018
38 Reads

A Case of Tophaceous Pseudogout on 18F-FDG PET/CT Imaging.

Clin Nucl Med 2019 Feb;44(2):e98-e100

From the Department of Nuclear Medicine, West China Hospital of Sichuan University, Chengdu, Sichuan, China.

A 53-year-old man with a 10-year history of gout was admitted to our hospital due to chronic low back pain. Initial CT examinations showed a high-density mass with bone destruction of bilateral facet joints at the L3 to L5 level. MRI findings also revealed lesion with the dural sac compression. Read More

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http://Insights.ovid.com/crossref?an=00003072-900000000-9742
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http://dx.doi.org/10.1097/RLU.0000000000002308DOI Listing
February 2019
23 Reads

Crowned Dens Syndrome: Calcium Pyrophosphate Deposition Disease Masquerading as Osteomyelitis.

J Rheumatol 2018 10;45(10):1422-1423

Department of Medicine, Divisions of Infectious Diseases and Hospital Medicine, University of Missouri, Columbia, Missouri, USA.

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http://dx.doi.org/10.3899/jrheum.170921DOI Listing
October 2018
14 Reads

Severe calcium pyrophosphate dihydrate deposition disease of the metacarpophalangeal joints.

BMJ Case Rep 2018 Sep 28;2018. Epub 2018 Sep 28.

Medicine/Rheumatology, University of Kentucky, Lexington, Kentucky, USA.

We report a case of calcium pyrophosphate deposition disease (CPPD) with an unusual presentation of severe chondrocalcinosis with atypical large burden deposited in the metacarpophalangeal joints as well as more typical deposition in wrists and knees as demonstrated on plain radiographs. A 77-year-old African-American woman 1-year status post parathyroidectomy for hyperparathyroidism initially presented to the rheumatology clinic to treat suspected rheumatoid arthritis given her pattern of joint involvement but was found to have CPPD. The patient's history is notable for end-stage renal disease which complicates medical management. Read More

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http://dx.doi.org/10.1136/bcr-2018-226132DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6169684PMC
September 2018
21 Reads

[Histopathological classification principles of rheumatic joint diseases : Contribution of pathology to the diagnosis].

Orthopade 2018 Nov;47(11):941-948

Unfallchirurgische Klinik, Sektion obere Extremität, Fuß- und Rheumachirurgie, Medizinische Hochschule Hannover, Hannover, Deutschland.

Even though the diagnostics of rheumatic joint diseases are mostly based on clinical, immunoserological and imaging criteria, histopathology can also make a significant contribution. This is particularly true for clinically unclear monoarticular and periarticular diseases. The contribution of histopathology to the diagnosis of rheumatic diseases is manifold since the histopathological differential diagnosis includes the complete spectrum of synovial diseases. Read More

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http://dx.doi.org/10.1007/s00132-018-3649-xDOI Listing
November 2018
10 Reads

Crystallising the role of adrenocorticotrophic hormone in the management of acute gout: a review.

Authors:
Muhammad K Nisar

Clin Exp Rheumatol 2019 Jan-Feb;37(1):137-145. Epub 2018 Aug 29.

Luton and Dunstable University Hospital NHSFT, Luton, UK.

Objectives: Acute gout is traditionally treated with NSAIDs, corticosteroids, and colchicine. However, the presence of comorbid conditions and advancing age, often seen in hospitalised patients, may prevent their use. We reviewed the published data on the use of ACTH in the treatment of acute gouty arthritis. Read More

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May 2019
8 Reads

Localised foot and ankle amyloid deposition.

Pathol Res Pract 2018 Oct 27;214(10):1661-1666. Epub 2018 Aug 27.

Department of Histopathology, NDORMS, University of Oxford, Nuffield Orthopaedic Centre, Oxford, OX3 7HE, UK. Electronic address:

Background: Localised (transthyretin-associated) amyloid is commonly seen in articular/periarticular tissues of elderly individuals. Whether age-associated, amyloid deposition occurs in foot and ankle (F&A) tissues has not previously been investigated. In this study we assessed the nature and frequency of F&A amyloid deposition and determined whether it is associated with age and/or specific articular/periarticular F&A lesions. Read More

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http://dx.doi.org/10.1016/j.prp.2018.08.027DOI Listing
October 2018
12 Reads

Clinical features and risk of recurrence of acute calcium pyrophosphate crystal arthritis.

Clin Exp Rheumatol 2019 Mar-Apr;37(2):254-259. Epub 2018 Jul 19.

Division of Rheumatology, Department of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.

Objectives: It is unclear whether attack recurrence rates are similar between acute calcium pyrophosphate (CPP) crystal arthritis and gout. This study compared the clinical features and recurrence rates of both conditions.

Methods: In this retrospective study, we reviewed 106 patients with acute CPP crystal arthritis (based on the presence of CPP crystals and/or chondrocalcinosis) and 173 patients with gout (based on the presence of monosodium urate crystals). Read More

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May 2019
17 Reads

[Update on Gout and Calcium pyrophosphate deposition (CPPD)].

Dtsch Med Wochenschr 2018 Aug 7;143(16):1157-1166. Epub 2018 Aug 7.

The metabolic diseases gout and calciumpyrophosphate deposition (CPPD) (formerly: chondrocalcinosis/pseudogout) are crystal arthropathies which are caused by crystals in synovial fluid and in the case of gout also in periarticular structures. Today, in particular gout is considered as an auto-inflammatory process since phagocytosis of monosodium urate crystals by monocytes/macrophages results in the activation of the innate immune system by activation of the NRLP3-Inflammasome and consecutive secretion of the key cytokine interleukin-1ß and other pro-inflammatory cytokines. The prevalence of both crystal arthropathies rises with increasing age of patients. Read More

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http://dx.doi.org/10.1055/a-0504-5684DOI Listing
August 2018
16 Reads

Does early seronegative arthritis develop into rheumatoid arthritis? A 10-year observational study.

Clin Exp Rheumatol 2019 Jan-Feb;37(1):37-43. Epub 2018 Jun 7.

Department of Rheumatology, Central Hospital of Central Finland, Jyväskylä, Finland.

Objectives: To investigate the 10-year clinical course of patients with seronegative arthritis with the emphasis of reclassification of diagnoses when applicable.

Methods: A total of 1030 patients including 435 seronegative cases were classified as early RA in 1997-2005 at Jyväskylä Rheumatology Centre and prospectively scheduled for a ten-year follow-up. Clinical data from the follow-up visits and the case-reports until and including the 10-year visit or death, whichever happened earlier, were retrospectively collected and reviewed with re-classification of the cases when applicable. Read More

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May 2019
20 Reads

Synovial fluid uric acid level aids diagnosis of gout.

Biomed Rep 2018 Jul 14;9(1):60-64. Epub 2018 May 14.

Department of Rheumatology, Bangabandhu Sheikh Mujib Medical University, Shahbag, Dhaka-1000, Bangladesh.

Examination of urate crystal in synovial fluid (SF) remains the gold standard for diagnosis of gout, but is not universally available. SF uric acid (UA) level may be measured by the uricase method with an automated analyzer. The present study aimed to evaluate the utility of SF to serum UA ratio (SSR) for diagnosis of gout. Read More

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http://dx.doi.org/10.3892/br.2018.1097DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6007039PMC
July 2018
17 Reads

Systematic Overview of Solid Particles and Their Host Responses.

Authors:
Fei Shu Yan Shi

Front Immunol 2018 28;9:1157. Epub 2018 May 28.

Department of Basic Medical Sciences, Institute for Immunology, Center for Life Sciences, Beijing Key Laboratory for Immunological Research on Chronic Diseases, Tsinghua University, Beijing, China.

Crystalline/particulate substances trigger a plethora of signaling events in host cells. The most prominent consequence is the inflammatory reactions that underlie crystal arthropathies, such as gout and pseudogout. However, their impact on our health was underestimated. Read More

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http://dx.doi.org/10.3389/fimmu.2018.01157DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5985299PMC
August 2019
5 Reads

Emergent nanotherapies in microcrystal-induced arthritis.

Int Immunopharmacol 2018 Aug 8;61:197-203. Epub 2018 Jun 8.

Laboratorio de Líquido Sinovial, Instituto Nacional de Rehabilitación "Luis Guillermo Ibarra-Ibarra (INR-LGII), Calz. México-Xochimilco No. 289, Col. Arenal de Guadalupe, Delegación Tlalpan, C.P. 14389 Ciudad de México, Mexico.

The anti-inflammatory and immunomodulatory effects of nanoparticles in several chronic diseases have been extensively researched. The aim of this review is to examine how nanoparticles modulate the inflammatory pathways that characterize the most prevalent forms of microcrystal-induced arthritis, including gout, pseudogout, and BCP-induced arthritis. The nanoparticles of chitosan-coated calcium phosphate, uricase, aceclofenac, and gold have been investigated in crystal-inducedarthritis. Read More

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http://dx.doi.org/10.1016/j.intimp.2018.06.007DOI Listing
August 2018
39 Reads
2.472 Impact Factor

Diagnosis and Treatment of Gout and Pseudogout for Everyday Practice.

Prim Care 2018 Jun;45(2):213-236

San Antonio Uniformed Services Health Consortium, Department of Rheumatology, 3851 Roger Brooke Drive, San Antonio, TX 78234, USA.

Gout and pseudogout are crystalline arthropathies commonly seen in primary care. It is important to understand their pathophysiology to facilitate recognition and appropriate treatment. Prompt gouty arthritis treatment relieves short-term suffering. Read More

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http://dx.doi.org/10.1016/j.pop.2018.02.004DOI Listing
June 2018
32 Reads

Acute arthritis: predictive factors and current practice in the approach to diagnosis and management across two hospitals in Sydney.

Intern Med J 2018 09;48(9):1087-1095

Department of Rheumatology, Westmead Hospital, Sydney, New South Wales, Australia.

Background: Literature pertaining to the predictive factors for septic arthritis is limited.

Aims: The primary objective was to investigate the predictive factors for septic arthritis. The secondary objectives were to investigate the predictive factors for crystal arthritis and to explore current practices in the management of acute arthritis. Read More

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http://dx.doi.org/10.1111/imj.13969DOI Listing
September 2018
3 Reads

Coexisting Gout and Chondrocalcinosis on Hand Radiograph.

J Rheumatol 2018 05;45(5):723-724

Department of Rheumatology, University Teaching Hospital, Besançon, France. Ethics approval for this case report was not required in accordance with the policy of the authors' institution.

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http://dx.doi.org/10.3899/jrheum.171154DOI Listing
May 2018
32 Reads

Therapy for CPPD: Options and Evidence.

Curr Rheumatol Rep 2018 04 19;20(6):31. Epub 2018 Apr 19.

Instituto de Investigación Sanitaria y Biomédica de Alicante (ISABIAL), Universidad Miguel Hernández, Alicante, Spain.

Purpose Of Review: Current evidence and accumulated experience for the management of calcium pyrophosphate deposition disease (CPPD) are presented.

Recent Findings: Contrary to other rheumatic inflammatory conditions that account for high interest and growing research, advances in treating CPPD are still very limited and mostly derive from those achieved in gout. Once formed, calcium pyrophosphate crystals cannot be dissolved; therefore, management relies on the control of crystal-derived inflammation. Read More

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http://dx.doi.org/10.1007/s11926-018-0739-zDOI Listing
April 2018
35 Reads

Diagnosis of pseudo-gout (calcium pyrophosphate deposition disease) clinched on cytology.

Diagn Cytopathol 2018 Sep 11;46(9):748-751. Epub 2018 Apr 11.

Department of Pathology, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India.

Calcium pyrophosphate dihydrate (CPPD) deposition disease is a metabolic arthropathy which results from deposition of calcium pyrophosphate crystals in and around joints especially the hyaline cartilage and disc material. This metabolic disease in uncommon in the smaller joints and multiple diagnostic modalities along with biochemical investigations would be necessary for definite diagnosis. We highlight the case of a 48 year old male who presented with a painful mass at the base of left thumb and was clinic-radiologically suspected as malignancy. Read More

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http://dx.doi.org/10.1002/dc.23939DOI Listing
September 2018
14 Reads

Review: Unmet Needs and the Path Forward in Joint Disease Associated With Calcium Pyrophosphate Crystal Deposition.

Arthritis Rheumatol 2018 08 14;70(8):1182-1191. Epub 2018 Jun 14.

Veterans Affairs, University of California at San Diego, San Diego, California.

Calcium pyrophosphate (CPP) crystal deposition (CPPD) is prevalent and can be associated with synovitis and joint damage. The population of elderly persons predominantly affected by CPPD is growing rapidly. Since shortfalls exist in many aspects of CPPD, we conducted an anonymous survey of CPPD unmet needs, prioritized by experts from the Gout, Hyperuricemia and Crystal-Associated Disease Network. Read More

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http://dx.doi.org/10.1002/art.40517DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6105380PMC
August 2018
43 Reads

Maltese cross interpretation. Comment on: "Acute phospholipid microspherule associated arthritis: Is it rare?" by Coiffier et al., Joint Bone Spine 2017;84;537-40.

Authors:
Bruce Rothschild

Joint Bone Spine 2018 05 23;85(3):391. Epub 2018 Feb 23.

West Virginia University School of Medicine, 1, Medical center DR, Morgantown, WV 26501, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jbspin.2018.02.003DOI Listing
May 2018
4 Reads

Crystal-induced oligoarthritis triggered by pembrolizumab, an immune checkpoint inhibitor.

Joint Bone Spine 2018 10 4;85(5):647-648. Epub 2018 Feb 4.

Division of rheumatology, Beth Israel Deaconess medical center, Harvard medical school, Boston, MA 02215, United States.

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http://dx.doi.org/10.1016/j.jbspin.2018.01.009DOI Listing
October 2018
6 Reads

Differential diagnostic perspectives provided by en face microscopic examination of articular surface defects.

Clin Rheumatol 2018 Mar 4;37(3):831-836. Epub 2018 Feb 4.

Department of Vertebrate Paleontology, Carnegie Museum, Pittsburgh, PA, 15213, USA.

Surface defects have a central position in diagnosis of articular pathology. Recognizing the limitations of standard radiologic techniques and those imposed by positioning and averaging artifacts on CT evaluation, direct visualization of surface defects was pursued to identify disease characteristics that would facilitate interpretation of radiologic findings. Epi-illumination surface microscopy was utilized to examine macroscopically recognized articular surface defects in individuals in the Hamann-Todd, Terry, and Huntington human skeletal collections with previously verified diagnoses of rheumatoid arthritis, spondyloarthropathy, juvenile inflammatory arthritis (JIA), calcium pyrophosphate deposition disease (CPPD), gout, metastatic cancer, multiple myeloma, septic arthritis, tuberculosis, fungal arthritis, histiocytosis and sickle cell anemia (Rothschild and Rothschild Clin Infect Dis 20(5):1402-1408, 1995; Rothschild et al. Read More

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http://dx.doi.org/10.1007/s10067-018-4001-xDOI Listing
March 2018
28 Reads

A Radiographic Double Contour Sign Mimicking Pseudogout.

J Clin Rheumatol 2018 Mar;24(2):92

From the Department of Rheumatology, University Diderot Paris-7, APHP, Bichat Claude Bernard hospital, 46 rue Henri Huchard 75877 Paris cedex 18, France.

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http://dx.doi.org/10.1097/RHU.0000000000000640DOI Listing
March 2018
6 Reads