1,672 results match your criteria Gout Imaging


Advanced Ulcerated Squamous Cell Carcinoma of the Hand with Locoregional Axillary Lymph Node Metastasis - Case Report and Literature Review.

Open Access Maced J Med Sci 2019 Mar 14;7(5):791-793. Epub 2019 Mar 14.

Center for Physical and Rehabilitative Medicine, Städtisches Klinikum Dresden, Dresden, Germany.

Background: Cutaneous squamous cell carcinoma (SCC) of the hand is the most common soft-tissue malignancy in this particular region. A literature survey suggested a higher rate of metastases in advanced SCC of the hand compared to head-and-neck cutaneous SCC.

Case Report: An 84-year-old man presented with an ulcerated firm tumour on the dorsum of his right hand. Read More

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http://dx.doi.org/10.3889/oamjms.2019.200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447345PMC
March 2019
1 Read

Imaging in rheumatoid arthritis: the role of magnetic resonance imaging and computed tomography.

Radiol Med 2019 Mar 18. Epub 2019 Mar 18.

Department of Radiology, Bispebjerg and Frederiksberg Hospital, University of Copenhagen, Copenhagen, Denmark.

In suspected and diagnosed rheumatoid arthritis (RA), magnetic resonance imaging (MRI) allows detection of all relevant pathologies, such as synovitis, tenosynovitis, bone marrow edema (osteitis), bone erosion and cartilage damage. MRI is more sensitive than clinical examination for monitoring disease activity (i.e. Read More

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http://link.springer.com/10.1007/s11547-019-01014-y
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http://dx.doi.org/10.1007/s11547-019-01014-yDOI Listing
March 2019
4 Reads

The application of dual-energy computed tomography in the diagnosis of musculoskeletal disorders: a review of current concepts and applications.

Radiol Med 2019 Mar 4. Epub 2019 Mar 4.

Radiology Department, Università Politecnica delle Marche, Via Conca 71, 60020, Ancona, Italy.

With the assistance of innovations in scanner engineering and software design, dual-energy computed tomography (DECT) is an advanced imaging method that has been developed over the last decade. With its unique ability to differentiate materials by their atomic number, DECT has opened new perspectives in imaging. The principal advantages of DECT over conventional CT in the musculoskeletal setting relate to the additional information provided regarding tissue composition, artifact reduction and image optimization. Read More

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http://dx.doi.org/10.1007/s11547-019-01015-xDOI Listing
March 2019
3 Reads

mTOR inhibition by metformin impacts monosodium urate crystal-induced inflammation and cell death in gout: a prelude to a new add-on therapy?

Ann Rheum Dis 2019 May 27;78(5):663-671. Epub 2019 Feb 27.

Department of Rheumatology and Clinical Immunology, Laboratory of Translational Immunology, University Medical Center Utrecht, Utrecht, The Netherlands.

Objective: Gout is the most common inflammatory arthritis worldwide, and patients experience a heavy burden of cardiovascular and metabolic diseases. The inflammation is caused by the deposition of monosodium urate (MSU) crystals in tissues, especially in the joints, triggering immune cells to mount an inflammatory reaction. Recently, it was shown that MSU crystals can induce mechanistic target of rapamycin (mTOR) signalling in monocytes encountering these crystals in vitro. Read More

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http://dx.doi.org/10.1136/annrheumdis-2018-214656DOI Listing
May 2019
1 Read
10.377 Impact Factor

The classical NLRP3 inflammasome controls FADD unconventional secretion through microvesicle shedding.

Cell Death Dis 2019 Feb 25;10(3):190. Epub 2019 Feb 25.

Department of Infection, Immunity and Inflammation, Cochin Institute, 75014, Paris, France.

Fas-associated death domain (FADD) is a key adaptor molecule involved in numerous physiological processes including cell death, proliferation, innate immunity and inflammation. Therefore, changes in FADD expression have dramatic cellular consequences. In mice and humans, FADD regulation can occur through protein secretion. Read More

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http://dx.doi.org/10.1038/s41419-019-1412-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6389912PMC
February 2019
1 Read

A Case of Calcium Pyrophosphate Deposition Disease Involving a Lumbar Facet Joint Following Urinary Tract Infection.

Intern Med 2019 Feb 25. Epub 2019 Feb 25.

Disease Control and Prevention Center, National Center for Global Health and Medicine, Japan.

A 75-year-old woman was admitted with urosepsis due to Escherichia coli infection. After improvement with a ureteral stent and antimicrobial agent, she complained of back pain and showed elevated inflammation marker levels. Arthralgia and arthritis of multiple peripheral joints were noted, and radiography indicated cartilage calcification. Read More

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http://dx.doi.org/10.2169/internalmedicine.2099-18DOI Listing
February 2019
1 Read

Gouty spondylodiscitis with lumbar vertebral body retrolisthesis: A case report.

Medicine (Baltimore) 2019 Feb;98(7):e14415

Orthopaedics Surgery Department, China-Japan Union Hospital of Jilin University, Changchun, Jilin Province, China.

Rationale: Gout occurs mainly in joints, but rarely in the spine. In the spine, urate crystals can cause intervertebral space instability but rarely lead to retrolisthesis. Here, we present an extremely rare disease with gout invaded the intervertebral disc with lumbar retrolisthesis. Read More

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http://dx.doi.org/10.1097/MD.0000000000014415DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6408027PMC
February 2019
7 Reads

A new association: acute macular neuroretinopathy in acute optic neuritis.

Acta Ophthalmol 2019 Feb 13. Epub 2019 Feb 13.

Clinical Research Department, Fondation Ophtalmologique Adolphe de Rothschild, Paris, France.

Background: Acute optic neuritis (AON) is a common optic nerve disease leading to retrograde degeneration of optic nerve axons, reflected by thinning of the inner retinal layers on optical coherence tomography. On the contrary, acute macular neuroretinopathy (AMN) type 2 is a rare outer retinal disorder that leads to thinning of the outer nuclear layers and is diagnosed by multimodal imaging. The aim of this study was to report a new association between these two diseases. Read More

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http://dx.doi.org/10.1111/aos.14054DOI Listing
February 2019
1 Read

Resveratrol-Induced Xenophagy Promotes Intracellular Bacteria Clearance in Intestinal Epithelial Cells and Macrophages.

Front Immunol 2018 14;9:3149. Epub 2019 Jan 14.

AgroSup Dijon, PAM UMR A 02.102, University Bourgogne Franche-Comté, Dijon, France.

Autophagy is a lysosomal degradation process that contributes to host immunity by eliminating invasive pathogens and the modulating inflammatory response. Several infectious and immune disorders are associated with autophagy defects, suggesting that stimulation of autophagy in these diseases should be beneficial. Here, we show that resveratrol is able to boost xenophagy, a selective form of autophagy that target invasive bacteria. Read More

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http://dx.doi.org/10.3389/fimmu.2018.03149DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339935PMC
January 2019
7 Reads

Odontoid cervical gout causing atlantoaxial instability: case report.

J Neurosurg Spine 2019 Jan 25:1-4. Epub 2019 Jan 25.

Departments of1Neurosurgery and.

The authors present a case report of a patient discovered to have a rotatory subluxation of the C1-2 joint and a large retroodontoid pannus with an enhancing lesion in the odontoid process eventually proving to be caused by gout. This patient represented a diagnostic conundrum as she had known prior diagnoses of not only gout but also sarcoidosis and possible rheumatoid arthritis, and was in the demographic range where concern for an oncological process cannot fully be ruled out. Because she presented with signs and symptoms of atlantoaxial instability, she required posterior stabilization to reduce the rotatory subluxation and to stabilize the C1-2 instability. Read More

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http://dx.doi.org/10.3171/2018.9.SPINE18122DOI Listing
January 2019
15 Reads

A 3T Phase-Sensitive Inversion Recovery MRI Sequence Improves Detection of Cervical Spinal Cord Lesions and Shows Active Lesions in Patients with Multiple Sclerosis.

AJNR Am J Neuroradiol 2019 Feb 24;40(2):370-375. Epub 2019 Jan 24.

From the Departments of Neuroradiology (A.F., J.S., J.C.S., A.L.)

Background And Purpose: Magnetic Resonance Imaging is the modality of choice to detect spinal cord lesions in patients with Multiple Sclerosis (MS). However, this imaging is challenging. New sequences such as phase-sensitive inversion recovery have been developed to improve detection. Read More

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http://dx.doi.org/10.3174/ajnr.A5941DOI Listing
February 2019
2 Reads

Unusual presentation of gouty tophus in the liver with subsequent appearance in the same site of HCC: a correlate diagnosis? Case report.

World J Surg Oncol 2019 Jan 8;17(1):10. Epub 2019 Jan 8.

Department of Clinical and Experimental Sciences, Surgical Clinic, University of Brescia, Brescia, Italy.

Background: Although gout is a common disease, the presence of gouty tophi outside joints is rare and in literature, there is to date only one report of hepatic tophaceous nodule. We would like to highlight here the difficult diagnostic workup in a patient with history of cancer and the presence of a tophus inside the liver. Moreover, we address the possible etiologic role of chronic inflammation related to tophi and liver cancer. Read More

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http://dx.doi.org/10.1186/s12957-018-1546-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6325729PMC
January 2019
11 Reads

Starvation-induced diplopia and weakness: a case of beriberi and Wernicke's encephalopathy.

BMJ Case Rep 2019 Jan 3;12(1). Epub 2019 Jan 3.

Department of Internal Medicine, Singapore General Hospital, Singapore.

A 56-year-old teetotaller man with hypertension and gout presented with a week duration of painless worsening diplopia on a background of loss of weight and appetite, generalised lethargy and weakness for 1 year. On examination, he was noted to be hypothermic and tachycardic with generalised muscle wasting. Proximal myopathy, lower limb fasciculations and areflexia, restricted bilateral eye abduction and nystagmus were observed. Read More

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http://dx.doi.org/10.1136/bcr-2018-227412DOI Listing
January 2019
21 Reads

Polyarticular arthropathy and encephalopathy in a 70-year-old woman.

BMJ Case Rep 2018 Dec 13;11(1). Epub 2018 Dec 13.

Bendat Respiratory Research and Development Fund, Perth, Western Australia, Australia.

A 70-year-old woman with a background of portopulmonary hypertension, managed with sildenafil and oral diuretics, and cirrhosis, presented with acute on chronic haemorrhoidal bleeding, iron deficiency anaemia and worsening right heart failure. She presented in a normal conscious and cognitive state. Management involved intravenous diuresis with frusemide and blood transfusion. Read More

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http://dx.doi.org/10.1136/bcr-2018-227058DOI Listing
December 2018
5 Reads

Pilot trial of inosine to elevate urate levels in amyotrophic lateral sclerosis.

Ann Clin Transl Neurol 2018 Dec 22;5(12):1522-1533. Epub 2018 Oct 22.

Neurological Clinical Research Institute (NCRI) Massachusetts General Hospital (MGH) Boston Massachusetts.

Objective: To test the safety, tolerability, and urate-elevating capability of the urate precursor inosine taken orally or by feeding tube in people with amyotrophic lateral sclerosis (ALS).

Methods: This was a pilot, open-label trial in 25 participants with ALS. Treatment duration was 12 weeks. Read More

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http://dx.doi.org/10.1002/acn3.671DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6292193PMC
December 2018
2 Reads

Mitochondrial Dynamin-Related Protein 1 (DRP1) translocation in response to cerebral glucose is impaired in a rat model of early alteration in hypothalamic glucose sensing.

Mol Metab 2019 Feb 27;20:166-177. Epub 2018 Nov 27.

Centre des Sciences du Goût et de l'Alimentation, UMR CNRS 6265, INRA 1324, AgroSup, Univ. Bourgogne Franche-Comté, F-21000 Dijon, France. Electronic address:

Objective: Hypothalamic glucose sensing (HGS) initiates insulin secretion (IS) via a vagal control, participating in energy homeostasis. This requires mitochondrial reactive oxygen species (mROS) signaling, dependent on mitochondrial fission, as shown by invalidation of the hypothalamic DRP1 protein. Here, our objectives were to determine whether a model with a HGS defect induced by a short, high fat-high sucrose (HFHS) diet in rats affected the fission machinery and mROS signaling within the mediobasal hypothalamus (MBH). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22128778183109
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http://dx.doi.org/10.1016/j.molmet.2018.11.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358535PMC
February 2019
20 Reads

Overview of Metatarsalgia.

Orthopedics 2019 Jan 13;42(1):e138-e143. Epub 2018 Dec 13.

Metatarsalgia can be viewed as more of a symptom rather than a distinct diagnosis. Timing of forefoot pain during the gait cycle and evaluation of whether the pain is from anatomic abnormalities, indirect overloading, or iatrogenic causes can suggest a specific metatarsalgia etiology. A thorough physical examination of the lower extremity, especially evaluation of the plantar foot, and weight-bearing radiographs are critical for diagnosis and treatment. Read More

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https://www.healio.com/doiresolver?doi=10.3928/01477447-2018
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http://dx.doi.org/10.3928/01477447-20181206-06DOI Listing
January 2019
13 Reads

Reliability of OMERACT ultrasound elementary lesions in gout: results from a multicenter exercise.

Rheumatol Int 2019 Apr 11;39(4):707-713. Epub 2018 Dec 11.

Rheumatology Unit, Instituto de Rehabilitación Psicofísica, Echeverria 955, Buenos Aires, C1428DQG, Argentina.

The aim of this study was to evaluate the reliability of the outcome measures in rheumatology (OMERACT) definitions for ultrasound (US) elementary lesions in gout through an image reading exercise. Images from patients with gout (static images and videos) were collected. As an initial step, we carried out a image reading exercise within the experts of the Pan-American League of Associations for Rheumatology (PANLAR) US Study Group (n = 16). Read More

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http://dx.doi.org/10.1007/s00296-018-4220-0DOI Listing
April 2019
6 Reads

Resveratrol attenuates the MSU crystal-induced inflammatory response through the inhibition of TAK1 activity.

Int Immunopharmacol 2019 Feb 8;67:62-68. Epub 2018 Dec 8.

Institute of Rheumatology and Immunology, The Affiliated Hospital of North Sichuan Medical College, 63# Wenhua Road, Nanchong 637000, Sichuan, China; Sichuan Key Laboratory of Medical Imaging, North SiChuan Medical College, 234# Fujiang Road, Nanchong 637000, Sichuan, China; Preclinical School of North SiChuan Medical College, 234# Fujiang Road, Nanchong 637000, Sichuan, China. Electronic address:

TAK1 is closely associated with the NF-κB and MAPK signaling pathways. In the present study, we aimed to explore the relationship between TAK1 and gout as well as the effects of resveratrol on TAK1 activity and MSU crystal-induced inflammation. The expression levels of total TAK1 and phosphorylated TAK1 in gout patients were detected by western blotting. Read More

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http://dx.doi.org/10.1016/j.intimp.2018.12.004DOI Listing
February 2019
4 Reads

Should we treat patients with radiologically isolated syndrome (RIS)? No.

Authors:
O Gout

Rev Neurol (Paris) 2018 Dec 16;174(10):693-695. Epub 2018 Nov 16.

Department of neurology, fondation ophtalmologique A.de-Rothschild, 29, rue Manin, 75019 Paris, France. Electronic address:

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http://dx.doi.org/10.1016/j.neurol.2018.05.002DOI Listing
December 2018
2 Reads

Diagnostic Imaging and Management of Common Intra-articular and Peri-articular Soft Tissue Tumors and Tumorlike Conditions of the Knee.

J Knee Surg 2019 Apr 16;32(4):322-330. Epub 2018 Nov 16.

Department of Orthopedic Surgery, Wake Forest University School of Medicine, Winston-Salem, North Carolina.

Intra-articular (IA) and peri-articular (PA) tumors of the knee are frequently encountered by orthopaedic surgeons. Nonetheless, due to the possibility of great morbidity and potential mortality, it is important to recognize and differentiate between benign and malignant lesions in a timely manner. Therefore, the purpose of this article is to provide a concise, practical, and updated review of commonly encountered IA and PA tumors including intratendinous gout, synovial chondromatosis, schwannoma, pigmented villonodular synovitis, and synovial sarcoma, and a detailed description of differentiating features to include various imaging modalities. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/s-0038-1675609
Publisher Site
http://dx.doi.org/10.1055/s-0038-1675609DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6445722PMC
April 2019
15 Reads

Gout: Update on Dual-Energy Computed Tomography with Emphasis on Artifact Identification.

Curr Rheumatol Rep 2018 Nov 13;20(12):86. Epub 2018 Nov 13.

Department of Radiology, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL, 32224, USA.

Purpose Of Review: Gout is the most common inflammatory arthritis and is increasing in prevalence and incidence in many countries worldwide. Accurate diagnosis is important to direct treatment that may include chronic medication. Burden quantification and treatment monitoring are key in the effective care of patients with gout. Read More

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http://link.springer.com/10.1007/s11926-018-0783-8
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http://dx.doi.org/10.1007/s11926-018-0783-8DOI Listing
November 2018
10 Reads

Diagnostic accuracy of dual-energy computed tomography and joint aspiration: a prospective study in patients with suspected gouty arthritis.

Clin Exp Rheumatol 2018 Nov-Dec;36(6):1061-1067. Epub 2018 Nov 5.

Department of Radiology, Charité-Universitätsmedizin Berlin Campus Mitte, Humboldt-Universität zu Berlin, Freie Universität Berlin, Germany.

Objectives: To validate the diagnostic benefit of dual-energy computed tomography (DECT) and synovial fluid aspiration in suspected gout.

Methods: A total of 43 patients with suspected gout underwent aspiration and DECT (320-row CT; Canon Medical Systems, Japan). The patients were assessed (gout vs. Read More

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March 2019
31 Reads

Coexisting polyarticular septic arthritis, gout and pseudogout.

BMJ Case Rep 2018 Oct 28;2018. Epub 2018 Oct 28.

Infectious Diseases, Blacktown Mount Druitt Hospital, Blacktown, New South Wales, Australia.

A case of a 67-year-old man with coexisting polyarticular septic arthritis due to group G , gout and pseudogout is presented. Septic arthritis of the left knee joint was further complicated by the development of an adjacent osteomyelitis. Appropriate management led to a full clinical recovery. Read More

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http://casereports.bmj.com/lookup/doi/10.1136/bcr-2018-22681
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http://dx.doi.org/10.1136/bcr-2018-226810DOI Listing
October 2018
19 Reads

Detection of uric acid crystal deposition by ultrasonography and dual-energy computed tomography: A cross-sectional study in patients with clinically diagnosed gout.

Medicine (Baltimore) 2018 Oct;97(42):e12834

Department of Rheumatology and Clinical Immunology.

The aim of our study was to compare the performance of ultrasonography (US) and dual-energy computed tomography (DECT) in detecting the crystal deposition at lower extremity joints in patients with gout. The correlation of imaging findings with microscopic findings was further assessed whenever aspiration is available.We recruited consecutive patients who were presented with arthritis of lower extremity from January 2012 to December 2014. Read More

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http://dx.doi.org/10.1097/MD.0000000000012834DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6211858PMC
October 2018
16 Reads

Urate crystal deposition, prevention and various diagnosis techniques of GOUT arthritis disease: a comprehensive review.

Health Inf Sci Syst 2018 Dec 8;6(1):19. Epub 2018 Oct 8.

School of Electrical Engineering, VIT University, Vellore, Tamilnadu India.

Gout is described as difficult in joint sore, uttermost ordinarily in the principal metatarsophalangeal joint, attend from formation of urate monosodium crystallization in a joint space. Analysis might be affirmed by recognizable proof of urate monosodium precious stones in synovial liquid of the influenced joint. There has been expanded enthusiasm for gout in common scholarly and clinical practice settings. Read More

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http://dx.doi.org/10.1007/s13755-018-0058-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6175756PMC
December 2018
1 Read

[CME Rheumatology 17/Answer: Suture Granuloma or Gout?]

Praxis (Bern 1994) 2018;107(21):1175-1176

2 OrthoPraxis Leumann, Orthopädische Chirurgie und Traumatologie des Bewegungsapparates und Sportmedizin, Basel.

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http://dx.doi.org/10.1024/1661-8157/a003087DOI Listing
January 2019
2 Reads

A Case of Tophaceous Pseudogout on 18F-FDG PET/CT Imaging.

Clin Nucl Med 2019 Feb;44(2):e98-e100

From the Department of Nuclear Medicine, West China Hospital of Sichuan University, Chengdu, Sichuan, China.

A 53-year-old man with a 10-year history of gout was admitted to our hospital due to chronic low back pain. Initial CT examinations showed a high-density mass with bone destruction of bilateral facet joints at the L3 to L5 level. MRI findings also revealed lesion with the dural sac compression. Read More

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http://Insights.ovid.com/crossref?an=00003072-900000000-9742
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http://dx.doi.org/10.1097/RLU.0000000000002308DOI Listing
February 2019
15 Reads

Magnetic Resonance Imaging in Rheumatology.

Magn Reson Imaging Clin N Am 2018 Nov;26(4):599-613

Department of Radiology and Diagnostic Imaging, University of Alberta, 8440 - 112 Street, Edmonton, Alberta T6G 2B7, Canada.

Magnetic resonance (MR) imaging has traditionally only played a small role in the clinical care of most patients with arthritis. However, with modern therapeutic strategies, early diagnosis is now more important than ever before. Consequently, advanced MRI techniques and applications now play a crucial role in managing an increasing proportion of rheumatology patients. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10649689183004
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http://dx.doi.org/10.1016/j.mric.2018.06.008DOI Listing
November 2018
18 Reads

Rat bite erosion: Gout.

J Med Imaging Radiat Oncol 2018 Oct;62 Suppl 1:150-151

Department of Radiology, Concord Repatriation General Hospital, Concord, New South Wales, Australia.

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http://doi.wiley.com/10.1111/1754-9485.25_12786
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http://dx.doi.org/10.1111/1754-9485.25_12786DOI Listing
October 2018
27 Reads

Porcupine appearance: Gout.

J Med Imaging Radiat Oncol 2018 Oct;62 Suppl 1:149

Department of Radiology, Concord Repatriation General Hospital, Concord, New South Wales, Australia.

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http://doi.wiley.com/10.1111/1754-9485.24_12786
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http://dx.doi.org/10.1111/1754-9485.24_12786DOI Listing
October 2018
2 Reads

Tophaceous Gout in the Lumbar Spine Causing Radiculopathy.

Reumatol Clin 2018 Oct 5. Epub 2018 Oct 5.

Servicio de Rehabilitación de Columna, Instituto Nacional de Rehabilitación «Luis Guillermo Ibarra Ibarra», Tlalpan, Ciudad de México, México.

Tophaceous deposits in lumbar spine is considered a rare condition. We report the case of a 44-year-old patient with low back pain and radiculopathy. Radiographs revealed lytic spondylolisthesis in L5. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S1699258X183018
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http://dx.doi.org/10.1016/j.reuma.2018.08.005DOI Listing
October 2018
15 Reads

Ultrasonography in gout: utility in diagnosis and monitoring.

Clin Exp Rheumatol 2018 Sep-Oct;36 Suppl 114(5):61-67. Epub 2018 Oct 1.

Copenhagen Center for Arthritis Research (COPECARE), Center for Rheumatology and Spine Diseases, Rigshospitalet, Glostrup, Copenhagen, Denmark.

The use of ultrasonography has a considerable potential for diagnosis and monitoring of gout due to its capacity to detect urate crystal deposits in joints, e.g. on the cartilage surface, visualised as the double contour sign, and in soft tissues, e. Read More

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January 2019
12 Reads

Update on imaging in gout: contrasting and comparing the role of dual-energy computed tomography to traditional diagnostic and monitoring techniques.

Clin Exp Rheumatol 2018 Sep-Oct;36 Suppl 114(5):53-60. Epub 2018 Oct 1.

Friedrich-Alexander-University Erlangen-Nürnberg (FAU), Department of Internal Medicine 3, Rheumatology and Immunology, Universitätsklinikum Erlangen, Germany.

In this systematic literature review, we update imaging modalities in gout, with a focus on newer technologies, particularly Dual-energy computed tomography (DECT). Conventional radiography (CR), ultrasonography (US), magnetic resonance imaging (MRI), computed tomography (CT) and dual-energy CT (DECT) have been used to evaluate different stages and clinical manifestations of gout and hyperuricaemia. We compare and contrast these modalities across the spectrum of this disease and of clinical scenarios and objectives (1). Read More

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January 2019
7 Reads

[Recent advances in gout: pathogenesis, diagnosis, comorbidities, treatment].

Orv Hetil 2018 Oct;159(40):1625-1636

Reumatológiai Tanszék, Debreceni Egyetem, Általános Orvostudományi Kar, Belgyógyászati Intézet Debrecen, Nagyerdei krt. 98., 4032.

After a "silence" period for decades, a great body of new information has become available about the pathogenesis, diagnosis and treatment of gout. New data on purine metabolism and urate transporters have been published. It has become evident that gout is an autoinflammatory disease involving the inflammasome and interleukin-1. Read More

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https://www.akademiai.com/doi/10.1556/650.2018.31270
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http://dx.doi.org/10.1556/650.2018.31270DOI Listing
October 2018
3 Reads

Spinal Gout-Dual-Energy CT for Noninvasive Diagnosis.

J Clin Rheumatol 2018 Sep 27. Epub 2018 Sep 27.

From the Department of Diagnostic Imaging, National University Hospital, Singapore.

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http://Insights.ovid.com/crossref?an=00124743-900000000-9914
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http://dx.doi.org/10.1097/RHU.0000000000000903DOI Listing
September 2018
4 Reads

Juvenile-onset gout and adipsic diabetes insipidus: A case report and literature review.

J Int Med Res 2018 Nov 1;46(11):4829-4836. Epub 2018 Oct 1.

1 Department of General Internal Medicine, Peking Union Medical College Hospital (PUMCH), Chinese Academy of Medical Science (CAMS) and Peking Union Medical College (PUMC), Beijing, China.

The prevalence of juvenile-onset gout has been increasing. Hereditary factors and secondary diseases should be considered in these patients. Adipsic diabetes insipidus (ADI) is characterized by arginine vasopressin (AVP) deficiency, which results in hypotonic polyuria, and dysfunction of thirst osmoreceptors, which results in failure to generate a thirst sensation in response to hypernatremia. Read More

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http://journals.sagepub.com/doi/10.1177/0300060518800114
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http://dx.doi.org/10.1177/0300060518800114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6259371PMC
November 2018
13 Reads

Severe calcium pyrophosphate dihydrate deposition disease of the metacarpophalangeal joints.

BMJ Case Rep 2018 Sep 28;2018. Epub 2018 Sep 28.

Medicine/Rheumatology, University of Kentucky, Lexington, Kentucky, USA.

We report a case of calcium pyrophosphate deposition disease (CPPD) with an unusual presentation of severe chondrocalcinosis with atypical large burden deposited in the metacarpophalangeal joints as well as more typical deposition in wrists and knees as demonstrated on plain radiographs. A 77-year-old African-American woman 1-year status post parathyroidectomy for hyperparathyroidism initially presented to the rheumatology clinic to treat suspected rheumatoid arthritis given her pattern of joint involvement but was found to have CPPD. The patient's history is notable for end-stage renal disease which complicates medical management. Read More

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http://dx.doi.org/10.1136/bcr-2018-226132DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6169684PMC
September 2018
10 Reads

Tophaceous gout of the cervical and thoracic spine with concomitant epidural infection.

AME Case Rep 2018 10;2:35. Epub 2018 Jul 10.

Department of Orthopaedics and Sports Medicine, Harborview Medical Center, Seattle, Washington, USA.

Tophaceous gout of the spine is an underappreciated source of back pain in patients with or without neurological decline. It has been reported to occur in the cervical, thoracic and lumbar spine. Rarely, does it occur at more than one region of the spine. Read More

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http://dx.doi.org/10.21037/acr.2018.07.01DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6155567PMC
July 2018
2 Reads

[Histopathological classification principles of rheumatic joint diseases : Contribution of pathology to the diagnosis].

Orthopade 2018 Nov;47(11):939-946

Unfallchirurgische Klinik, Sektion obere Extremität, Fuß- und Rheumachirurgie, Medizinische Hochschule Hannover, Hannover, Deutschland.

Even though the diagnostics of rheumatic joint diseases are mostly based on clinical, immunoserological and imaging criteria, histopathology can also make a significant contribution. This is particularly true for clinically unclear monoarticular and periarticular diseases. The contribution of histopathology to the diagnosis of rheumatic diseases is manifold since the histopathological differential diagnosis includes the complete spectrum of synovial diseases. Read More

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http://dx.doi.org/10.1007/s00132-018-3649-xDOI Listing
November 2018
3 Reads

Referral Patterns for Dual-Energy Computed Tomography in Diagnosis and Management of Gout: Ten-Year Experience at a Canadian Institution.

Can Assoc Radiol J 2018 Nov 22;69(4):430-436. Epub 2018 Sep 22.

Department of Radiology, Vancouver General Hospital, Vancouver, British Columbia, Canada.

Purpose: To analyze the utilization, indications, and outcomes of dual-energy computed tomography (DECT) gout imaging in clinical practice.

Methods: This retrospective study was ethics approved. Radiology reports of DECT gout scans between 2007 and 2016 were analyzed for trends of utilization, referral pattern, indication, and diagnosis. Read More

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http://dx.doi.org/10.1016/j.carj.2018.06.003DOI Listing
November 2018
5 Reads

Combining non-contrast and dual-energy CT improves diagnosis of early gout.

Eur Radiol 2019 Mar 17;29(3):1267-1275. Epub 2018 Sep 17.

Division of Rheumatology, Department of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, 06591, Republic of Korea.

Objectives: To determine the incremental value of non-contrast CT (NCCT) on dual-energy CT (DECT) in symptomatic first metatarsophalangeal (MTP) joints in early gout.

Methods: One hundred and fifteen painful joints were consecutively enrolled and gout was diagnosed based on the 2015 EULAR/ACR criteria and/or arthrocentesis. Two readers independently evaluated DECT alone and combined NCCT and DECT (NCCT+DECT) based on four semiquantitative scales. Read More

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http://dx.doi.org/10.1007/s00330-018-5716-4DOI Listing

The Role of Dual-Energy Computed Tomography in Musculoskeletal Imaging.

PET Clin 2018 Oct 17;13(4):567-578. Epub 2018 Aug 17.

Centre for International Affairs, The Jikei University, 3-25-8, Nishi-Shimbashi, Minato-ku, Tokyo 105-8461, Japan.

Dual-energy computed tomography (DECT) enables material decomposition and virtual monochromatic images by acquiring 2 different energy X-ray data sets. DECT can detect musculoskeletal pathologic conditions that CT alone cannot, and that would otherwise require MR imaging. In this review, the authors discuss several useful techniques and applications of DECT in musculoskeletal research: virtual monochromatic images, virtual noncalcium images, gout, iodine map, and tendons. Read More

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http://dx.doi.org/10.1016/j.cpet.2018.05.009DOI Listing
October 2018
1 Read

Pulmonary Artery Pseudoaneurysms in the Setting of Gout Polyarthropathy: A Case Report.

J Clin Med Res 2018 Oct 10;10(10):781-785. Epub 2018 Sep 10.

Radiology Department, The Prince Charles Hospital, Chermside, QLD 4032, Australia.

Pulmonary artery pseudoaneurysm is a dangerous pathology often missed as a differential and on imaging. With a 50% mortality rate early detection and intervention are critical to patient outcome, rendering diagnosis based on clinical grounds to be of paramount importance. A high index of suspicion should be placed on patients presenting with unprovoked hemoptysis, hemorrhage or hemothorax. Read More

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http://dx.doi.org/10.14740/jocmr3513wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6135000PMC
October 2018
4 Reads

Chronic carpal tunnel syndrome caused by covert tophaceous gout: A case report.

World J Clin Cases 2018 Sep;6(9):279-283

Department of Orthopaedic Surgery, Shanghai Jiaotong University Affiliated Sixth People's Hospital, Shanghai 200233, China.

Carpal tunnel syndrome (CTS) is well recognized as the most common type of peripheral neuropathy. A rare cause of CTS is tophaceous gout. Tophi deposits can accumulate in various structures including the flexor tendons, tendon sheaths, the carpal tunnel floor, transverse carpal ligament, and even the median nerve, causing various symptoms such as pain, numbness, and weakness. Read More

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http://www.wjgnet.com/2307-8960/full/v6/i9/279.htm
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http://dx.doi.org/10.12998/wjcc.v6.i9.279DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6134276PMC
September 2018
29 Reads

Highly sensitive olfactory biosensors for the detection of volatile organic compounds by surface plasmon resonance imaging.

Biosens Bioelectron 2019 Jan 31;123:230-236. Epub 2018 Aug 31.

Uni. Grenoble Alpes, CEA, CNRS, INAC-SyMMES, 17 Rue des Martyrs, 38000 Grenoble, France. Electronic address:

Nowadays, monitoring of volatile organic compounds (VOCs) is very important in various domains. In this work, we aimed to develop sensitive olfactory biosensors using odorant binding proteins (OBPs) as sensing materials. Three rat OBP3 derivatives with customized binding properties were designed and immobilized on the same chip for the detection of VOCs in solution by surface plasmon resonance imaging (SPRi). Read More

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http://dx.doi.org/10.1016/j.bios.2018.08.072DOI Listing
January 2019
2 Reads

Monosodium urate crystals reduce osteocyte viability and indirectly promote a shift in osteocyte function towards a proinflammatory and proresorptive state.

Arthritis Res Ther 2018 09 10;20(1):208. Epub 2018 Sep 10.

Department of Medicine, Bone & Joint Research Group, University of Auckland, Auckland, New Zealand.

Background: Bone erosion is a frequent complication of gout and is strongly associated with tophi, which are lesions comprising inflammatory cells surrounding collections of monosodium urate (MSU) crystals. Osteocytes are important cellular mediators of bone remodeling. The aim of this study was to investigate the direct effects of MSU crystals and indirect effects of MSU crystal-induced inflammation on osteocytes. Read More

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https://arthritis-research.biomedcentral.com/articles/10.118
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http://dx.doi.org/10.1186/s13075-018-1704-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6131786PMC
September 2018
3 Reads

Antiremodeling Effect of Xanthine Oxidase Inhibition in a Canine Model of Atrial Fibrillation.

Int Heart J 2018 Sep 29;59(5):1077-1085. Epub 2018 Aug 29.

Department of Cardiovascular Medicine, Kitasato University School of Medicine.

In a canine rapid atrial stimulation model of atrial fibrillation (AF), we have demonstrated an increased production of reactive oxygen species (ROS) along with electrical and structural remodeling. In the present study, we hypothesized that antioxidants can suppress atrial remodeling canines with AF. We therefore evaluated the effect of febuxostat, a xanthine oxidase (XO) inhibitor and a pure antioxidant, on atrial remodeling. Read More

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https://www.jstage.jst.go.jp/article/ihj/59/5/59_17-391/_art
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http://dx.doi.org/10.1536/ihj.17-391DOI Listing
September 2018
18 Reads

An Untypical Case of Gouty Infiltration of Both Peroneal Tendons and a Longitudinal Lesion of the Peroneus Brevis Tendon Mimicking Synovial Sarcoma.

Case Rep Orthop 2018 26;2018:8790916. Epub 2018 Jul 26.

Zentrum für Orthopädie und Unfallchirurgie, Städtisches Klinikum Saarbrücken, Saarbrücken, Germany.

We present a case of a 70-year-old male patient with an untypical gout infiltration of the peroneal tendons mimicking synovial sarcoma. The patient had a negative history of gout at initial presentation in our department. Magnetic resonance imaging of the region revealed a finding highly suspicious for synovial sarcoma of the peroneal tendons. Read More

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http://dx.doi.org/10.1155/2018/8790916DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6083480PMC
July 2018
3 Reads