Search Our Scientific Publications & Authors

Sci Rep 2021 May 11;11(1):10019. Epub 2021 May 11.

Division of Aging Research, Gwangju Center, Korea Basic Science Institute (KBSI), 49 Dosicheomdansaneop-ro, Nam-gu, Gwangju, 61751, South Korea.

Optical diffraction tomography (ODT) enables imaging of unlabeled intracellular components by measuring the three-dimensional (3D) refractive index (RI). We aimed to detect intracellular monosodium urate (MSU) crystals in synovial leukocytes derived from gout patients using ODT. The 3D RI values of the synthetic MSU crystals, measured by ODT, ranged between 1. Read More

BMJ Case Rep 2021 May 11;14(5). Epub 2021 May 11.

Division of Cardiology and Department of Radiology, George Washington University School of Medicine, Washington, DC, USA.

This report documents a rare case of COVID-19-associated constrictive pericarditis (CP) in the setting of a recent COVID-19 infection. A 55-year-old man with a history of hypertension and gout presented with acute hypoxic respiratory failure and was diagnosed with COVID-19 pneumonia with progression to acute respiratory distress syndrome. His hospital course was complicated by a large pericardial effusion; an emergent bedside transthoracic echocardiography was concerning for cardiac tamponade, so pericardiocentesis was performed. Read More

Autoimmun Rev 2021 May 7:102848. Epub 2021 May 7.

Rheumatology Unit, Bnai-Zion Medical Center and Technion, Haifa, Israel; Ruth & Bruce Rappaport Faculty of Medicine, Technion, Haifa, Israel. Electronic address:

Purpose: To reassess the diagnostic approach to a patient with a monoarticular disease in light of the up-to-date medical literature and to examine the practical utility of traditional and newer imaging tools in the setting of monoarthritis.

Results: The monoarticular disease can represent a medical emergency on the one hand and be a diagnostic conundrum on the other. The management rules of patients with monoarthritis have been established long ago, but various pitfalls still lead physicians off the right diagnosis at times. Read More

Int J Surg Case Rep 2021 Apr 27;82:105920. Epub 2021 Apr 27.

Michael Garron Hospital, Toronto, ON, Canada; University of Toronto, Toronto, ON, Canada.

Introduction And Importance: Tophacious gout presenting at the anterior cruciate ligament (ACL) is extremely rare and difficult to differentiate from other intraarticular pathology. This is mainly due to conventional diagnostic tools, such as MRI, producing ambiguous results versus pigmented villonodular synovitis (PVNS) and ganglion cysts.

Case Presentation: Here we report an individual in their late-20s with a gouty tophus located at the origin of the ACL in the knee. Read More

PLoS One 2021 22;16(4):e0247813. Epub 2021 Apr 22.

Department of Neuroradiology, Foundation Adolphe de Rothschild Hospital, Paris, France.

Background And Purpose: To compare 3D-Fast Gray Matter Acquisition with Phase Sensitive Inversion Recovery (3D-FGAPSIR) with conventional 3D-Short-Tau Inversion Recovery (3D-STIR) and sagittal T1-and T2-weighted MRI dataset at 3 Tesla when detecting MS spinal cord lesions.

Material And Methods: This prospective single-center study was approved by an institutional review board and enrolled participants from December 2016 to August 2018. Two neuroradiologists blinded to all data, individually analyzed the 3D-FGAPSIR and the conventional datasets separately and in random order. Read More

Beijing Da Xue Xue Bao Yi Xue Ban 2020 Oct;53(2):261-265

Department of Rheumatology and Clinical Immunology, Peking University First Hospital, Beijing 100034, China.

Objective: To explore the risk factors of detection of uric acid crystals by dual energy CT (DECT) in patients with gout diagnosed by gold standard.

Methods: From June 2011 to December 2018, clinical data of 29 patients were collected who were diagnosed with acute or chronic gout by positive polarized light analysis of joint synovial fluid in First Hospital of Peking University. Chi-square test, Logistic regression and -test were used. Read More

Br J Radiol 2021 May 16;94(1121):20200493. Epub 2021 Apr 16.

The Second School of Clinical Medicine, Southern Medical University, Guangzhou, China.

Objective: This study aimed to investigate the diagnostic performance of minimally invasive arthroscopy for knee gout when comparing with joint ultrasonography and dual-energy computed tomography (DECT).

Methods: From January 2016 to December 2018, 121 inpatients with knee joint swelling and pain were prospectively enrolled, including 63 gout patients and 58 non-gout patients. All patients underwent pre-operative ultrasonography and DECT to evaluate knee joint monosodium urate (MSU) deposits, followed by minimally invasive arthroscopy. Read More

Arthritis Res Ther 2021 Apr 15;23(1):115. Epub 2021 Apr 15.

Department of Medical Imaging, Chung Shan Medical University Hospital, Taichung City, Taiwan.

Background: Gout stems from both modifiable and genetic sources. We evaluated the risk of gout among Taiwanese adults with aldehyde dehydrogenase-2 (ALDH2) rs671 single nucleotide polymorphism (SNP) according to body mass index (BMI) and alcohol drinking.

Methods: We obtained information of 9253 individuals having no personal history of cancer from the Taiwan Biobank (2008-2016) and estimated the association between gout and independent variables (e. Read More

N Engl J Med 2021 Apr;384(15):1474-1475

National and Kapodistrian University of Athens, Athens, Greece

N Engl J Med 2021 Apr;384(15):1474

Bethesda, MD

BMC Musculoskelet Disord 2021 Apr 12;22(1):343. Epub 2021 Apr 12.

Department of Orthopedics, Inner Mongolia People's Hospital, No. 20 Zhao Wu Da Street, Inner Mongolia Autonomous Region, 010017, Hohhot, China.

Background: Gout is a metabolic disease characterized by recurrent episodes of acute arthritis. Gout has been reported in many locations but is rarely localized in the shoulder joint. We describe a rare case of gouty arthritis involving bilateral shoulder joints and leading to severe destructive changes in the right shoulder glenoid. Read More

Mil Med 2021 Apr 7. Epub 2021 Apr 7.

Department of Rheumatology, Tripler Army Medical Center, Honolulu, HI 96859, USA.

Urate crystal gout arthritis and calcium pyrophosphate deposition disease (CPPD) are crystalline arthropathies seen in middle age to elderly patients, but are also seen in the active duty military population. Flares of either can be identified by acute joint pain, associated swelling, tenderness, and warmth. Definitive diagnosis involves synovial analysis from arthrocentesis. Read More

Arthrosc Tech 2021 Feb 30;10(2):e499-e505. Epub 2021 Jan 30.

The Steadman Clinic, Vail, Colorado, U.S.A.

Popliteal tendon tears without concomitant damage to the cruciate ligaments or other posterolateral corner ligaments are rare entities with few studies reporting on their existence, with rare case reports discussing their treatment. Continued pain, instability, and effusions are typical symptoms, with magnetic resonance imaging being the main tool for diagnosis. Furthermore, monosodium urate crystals that induce gout have been shown to collect in the popliteal groove and thus may lead to degeneration and isolated tearing. Read More

Pan Afr Med J 2020 3;37:306. Epub 2020 Dec 3.

Faculté de Médecine de Monastir, Service d'Orthopédie, CHU Taher Sfar, Mahdia, Tunisia.

This study reports a case of gouty arthritis in the hip joint in a 57-year-old woman with diabetes and hypertension, with no history of gout, presenting with chronic pain in the right hip. Clinical examination showed obese patient, having painful right limping with lateral hip flexion during walking. Standard radiography objectified osteocondensing formations at the level of the anterior femoral neck. Read More

Eur J Neurol 2021 Mar 1. Epub 2021 Mar 1.

Service de Neurologie, Hôpital Maison-Blanche, Centre Hospitalier Universitaire de Reims, Reims, France.

Background And Purpose: Disease-modifying therapies (DMTs) have an impact on relapses and disease progression. Nonetheless, many patients with multiple sclerosis (MS) remain untreated. The objectives of the present study were to determine the proportion of untreated patients with MS followed in expert centers in France and to determine the predictive factors of nontreatment. Read More

Autophagy 2021 Jan 8;17(1):1-382. Epub 2021 Feb 8.

University of Crete, School of Medicine, Laboratory of Clinical Microbiology and Microbial Pathogenesis, Voutes, Heraklion, Crete, Greece; Foundation for Research and Technology, Institute of Molecular Biology and Biotechnology (IMBB), Heraklion, Crete, Greece.

In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Read More

J Orthop Case Rep 2020 Jul;10(4):17-19

Department of Surgical Oncology, Tata Memorial Centre, Homi Bhabha National Institute, Mumbai, Maharashtra, India.

Introduction: Gout is a metabolic disorder known to mimic other disorders. Here is a case report of a patient in which gout was mimicking giant cell tumour of bone.

Case Report: A 48-year-old lady presented with gradually progressive pain and swelling in the right foot. Read More

Front Neurol 2020 29;11:627077. Epub 2021 Jan 29.

Department of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing, China.

Optic perineuritis (OPN) is a special optic neuropathy that has a distinct etiology from neuromyelitis optica spectrum disorders (NMOSDs) or multiple sclerosis (MS)-related optic neuritis (ON). The mechanisms of how this inflammation developed and invaded the nerve sheath remain unknown. This study is aimed to analyze the etiology and different clinical characteristics of OPN in a Chinese patient population. Read More

Beijing Da Xue Xue Bao Yi Xue Ban 2020 Dec;53(1):143-149

Department of Rheumatology and Immunology, Peking University First Hospital, Beijing 100034, China.

Objective: To evaluate frequency and patterns, risk factors of MSU (monosodium urate) crystal deposition at lower extremity tendon by ultrasonography in gout patients, and to explore diagnostic value by ultrasonography.

Methods: Patients diagnosed with gout and age matched healthy controls had ultrasound scanning of both feet and knees including joints and tendons (achilles, quadriceps, and patellar tendon). Readers who scored the ultrasound scans for MSU crystal deposition were blinded to the patients' clinical diagnoses. Read More

Cancer Res 2021 Feb 2. Epub 2021 Feb 2.

Department of Internal Medicine I, University Hospital Ulm

Pancreatic ductal adenocarcinoma (PDAC) still presents with a dismal prognosis despite intense research. Better understanding of cellular homeostasis could identify druggable targets to improve therapy. Here we propose RAD50-interacting protein 1 (RINT1) as an essential mediator of cellular homeostasis in PDAC. Read More

Mod Rheumatol Case Rep 2021 Jan 25:1-6. Epub 2021 Jan 25.

Department of Orthopedic Surgery, Nagato General Hospital, Yamaguchi, Japan.

This is a very rare case of gouty tophus in the patella of a 31-year-old male, without any medical co-morbidities. The patient initially presented after an injury to left knee but came back months later due to persistence of pain. Surgical decision was made based on imaging findings in computed tomography and magnetic resonance imaging of an intraosseous lesion that has increased in size. Read More

Oxid Med Cell Longev 2020 31;2020:8706898. Epub 2020 Dec 31.

Institute of Rheumatology and Immunology, The Affiliated Hospital of North Sichuan Medical College, 63# Wenhua Road, Nanchong, 637000 Sichuan, Nanchong, China.

Acute gout is an inflammatory response induced by monosodium urate (MSU) crystals. HSP60 is a highly conserved stress protein that acts as a cellular "danger" signal for immune reactions. In this study, we aimed to investigate the role and molecular mechanism of HSP60 in gout. Read More

Joint Bone Spine 2021 05 20;88(3):105134. Epub 2021 Jan 20.

Rheumatology Department, CHRU de Besançon, boulevard Fleming, 25030 Besançon, France.

Radiographics 2021 Mar-Apr;41(2):543-558. Epub 2021 Jan 22.

From the Division of Musculoskeletal Radiology, Laboratório Delboni Auriemo, Diagnósticos da América SA (DASA), R. Dr. Diogo de Faria 1379, Vila Clementino, São Paulo, SP 04037-005, Brazil (J.E.C.A., S.R.N.C., A.K.T., F.N.C., A.Y.S., A.Y.A.); Division of Musculoskeletal Radiology, Alta Diagnósticos, São Paulo, Brazil (J.E.C.A., S.R.N.C., A.K.T., A.Y.S.); Musculoskeletal Imaging Division, Hospital Israelita Albert Einstein, São Paulo, Brazil (A.K.T.); Department of Diagnostic Imaging, Federal University of São Paulo, São Paulo, Brazil (F.N.C., A.Y.A.); Division of Musculoskeletal Radiology, Hospital do Coração (HCor), São Paulo, Brazil (A.K.T., A.Y.S.); and Teleimagem, São Paulo, Brazil (A.K.T., A.Y.S.).

Spinal pain due to facet joint disease is difficult to diagnose since the clinical history and physical examination findings are usually nonspecific. Facet joint disorders have a wide range of causes and, because of the potential for chronic back pain and disability, an accurate diagnosis is essential. The most frequent cause of pain in facet joints is osteoarthritis, which can be assessed at radiography, CT, or MRI. Read More

Radiologia 2021 Mar-Apr;63(2):127-144. Epub 2021 Jan 13.

Reumatóloga, profesor titular investigador, Instituto de Investigaciones, Fundación Universitaria de Ciencias de la Salud (FUCS), Bogotá, Colombia.

Background And Aims: Digital tomosynthesis has proven useful in the evaluation of damage to joints. This study aims to describe the most common digital tomosynthesis findings for four rheumatological entities and to compare the usefulness of this technique with that of other imaging techniques.

Materials And Methods: Following the PRISMA guidelines, we systematically searched the literature for articles about the use of digital tomosynthesis in rheumatoid arthritis, osteoarthritis, spondyloarthritis, and gout. Read More

Mult Scler 2021 Jan 11:1352458520981300. Epub 2021 Jan 11.

CHU de Caen, MS Expert Centre, Department of Neurology, avenue de la Côte-de-Nacre, Normandy University, Caen, France.

Background: A delayed onset of treatment effect, termed therapeutic lag, may influence the assessment of treatment response in some patient subgroups.

Objectives: The objective of this study is to explore the associations of patient and disease characteristics with therapeutic lag on relapses and disability accumulation.

Methods: Data from MSBase, a multinational multiple sclerosis (MS) registry, and OFSEP, the French MS registry, were used. Read More

Rheumatology (Oxford) 2021 Jan 7. Epub 2021 Jan 7.

ULR 4490, Marrow Adiposity and Bone Laboratory (MABLab), University of Lille, Lille, France.

Objective: To examine the accuracy of dual-energy computed tomography (DECT) vs ultrasound or their combination for the diagnosis of gout.

Methods: Using prospectively collected data from an outpatient rheumatology clinic at a tertiary-care hospital, we examined the diagnostic accuracy of either modality alone or their combination, by anatomical site (feet/ankles and/or knees), for the diagnosis of gout. We used two standards: (1) demonstration of monosodium urate crystals in synovial fluid (gold), and (2) modified (excluding DECT and ultrasound) 2015 ACR-EULAR gout classification criteria (silver). Read More

Rheumatology (Oxford) 2021 Jan 7. Epub 2021 Jan 7.

Rheumatology department, Lille Catholic Hospitals, Lille Catholic University, Lille, France.

Objectives: To determine whether the volume of monosodium urate (MSU) crystal deposition measured with dual-energy computed tomography (DECT) is predictive of short-term mortality and development of cardiovascular comorbidities and diabetes mellitus.

Methods: Patients with a diagnosis of gout having had baseline DECT scans of their knees and feet to measure the volume of MSU crystals deposition were included to undergo a follow-up visit. Risk factors for mortality and a composite variable (onset of any cardio-metabolic event) were examined using multivariable Cox models. Read More

J Stroke Cerebrovasc Dis 2021 Mar 30;30(3):105580. Epub 2020 Dec 30.

Department of Cardiology, Kocaeli Government Hospital, Gunes Street, 41300 Kocaeli, Turkey.

Objectives: Inflammation plays an important role in the development of atherosclerotic vascular disease, which is the leading cause of morbidity and mortality in the adult population. Several clinical trials have shown that suppression of the inflammatory response can delay or decrease the atherosclerotic process. The aim of this study was to investigate carotid intima-media thickness (CIMT) between patients with chronic disease history plus gout using colchicine and patients with cardiovascular risk factors. Read More

Ann Acad Med Singap 2020 Nov;49(11):931-933

Department of Diagnostic Imaging, Tan Tock Seng, Singapore.