17,259 results match your criteria Gout Imaging


Reliability of OMERACT ultrasound elementary lesions in gout: results from a multicenter exercise.

Rheumatol Int 2018 Dec 11. Epub 2018 Dec 11.

Rheumatology Unit, Instituto de Rehabilitación Psicofísica, Echeverria 955, Buenos Aires, C1428DQG, Argentina.

The aim of this study was to evaluate the reliability of the outcome measures in rheumatology (OMERACT) definitions for ultrasound (US) elementary lesions in gout through an image reading exercise. Images from patients with gout (static images and videos) were collected. As an initial step, we carried out a image reading exercise within the experts of the Pan-American League of Associations for Rheumatology (PANLAR) US Study Group (n = 16). Read More

View Article
December 2018

Evaluating the Efficacy and Adverse Effects of Clearing Heat and Removing Dampness Method of Traditional Chinese Medicine by Comparison with Western Medicine in Patients with Gout.

Evid Based Complement Alternat Med 2018 13;2018:8591349. Epub 2018 Nov 13.

Institute of Integrative Medicine, Dalian Medical University, No. 9, South Road of Lvshun, Dalian 116044, China.

In China, the method of clearing heat and removing dampness medicine of Chinese traditional medicine has been widely used on gout. However, the clinical effects are various and not summarized systematically. In this study, a large number of randomized controlled clinical trials were reviewed and analyzed and the clinical efficacy and adverse reactions of traditional Chinese medicine with clearing heat and removing dampness effects for the treatment of gout were systematically evaluated. Read More

View Article
November 2018

Resveratrol attenuates the MSU crystal-induced inflammatory response through the inhibition of TAK1 activity.

Int Immunopharmacol 2018 Dec 7;67:62-68. Epub 2018 Dec 7.

Institute of Rheumatology and Immunology, The Affiliated Hospital of North Sichuan Medical College, 63# Wenhua Road, Nanchong 637000, Sichuan, China; Sichuan Key Laboratory of Medical Imaging, North SiChuan Medical College, 234# Fujiang Road, Nanchong 637000, Sichuan, China; Preclinical School of North SiChuan Medical College, 234# Fujiang Road, Nanchong 637000, Sichuan, China. Electronic address:

TAK1 is closely associated with the NF-κB and MAPK signaling pathways. In the present study, we aimed to explore the relationship between TAK1 and gout as well as the effects of resveratrol on TAK1 activity and MSU crystal-induced inflammation. The expression levels of total TAK1 and phosphorylated TAK1 in gout patients were detected by western blotting. Read More

View Article
December 2018
1 Read

Gout in the Gilded Age: The Case of Richard Morris Hunt.

Authors:
Robert S Pinals

J Clin Rheumatol 2018 Dec 5. Epub 2018 Dec 5.

From the Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ.

Richard Morris Hunt, a distinguished American architect of the late 19th century (the Gilded Age), had onset of gout at age 41 years. His attacks became more frequent and severe, eventually leading to chronic pain and disability. His medical care by highly regarded physicians resulted in very limited benefit, but through his dedication and work ethic, he remained productive until his death at age 67 years. Read More

View Article
December 2018

Knowledge and practice in the management of asymptomatic hyperuricemia among primary health care physicians in Jeddah, Western Region of Saudi Arabia.

Saudi Med J 2018 Dec;39(12):1218-1225

Joint Program of Family Medicine, King Fahad Armed Forces Hospital, Jeddah, Kingdom of Saudi Arabia. E-mail.

Objectives: To assess knowledge and practice levels in asymptomatic hyperuricemia (AH) and investigate predictors of urate-lowering therapy (ULT) misprescribing among primary health care (PHC) physicians.

Methods: A cross-sectional study was conducted among 201 PHC physicians from December 2017 to May 2018. A based clinical guidelines for hyperuricemia management from American Professional Organizations, a semi-structured questionnaire was administered to collect demographic and professional data; knowledge and practice levels in management of AH; and barriers to the management of hyperuricemia and gout, with focus of the misprescribing of ULT in AH. Read More

View Article
December 2018

Does interindividual variability of saliva affect the release and metabolisation of aroma compounds ex-vivo? The particular case of elderly suffering or not from hyposalivation.

J Texture Stud 2018 Dec 5. Epub 2018 Dec 5.

Centre des Sciences du Goût et de l'Alimentation, UMR1324 INRA, UMR6265 CNRS Université de Bourgogne, Agrosup Dijon, F-21000 Dijon, France.

The aim of this work was to study the effects of interindividual variability of human elderly saliva on aroma release and metabolisation by ex vivo approaches. Thirty individuals suffering or not from hyposalivation were selected from a panel formed by 110 elderly people (aged >65 years old) that were matched by age and sex. Then, their stimulated saliva samples were independently incubated in presence of three aroma compounds (ethyl hexanoate, octanal, 2-nonanone) to perform headspace-gas chromatography (HS-GC) and liquid/liquid extraction-gas chromatography mass spectrometry (LLE-GC/MS) analyses. Read More

View Article
December 2018

How Would You Manage This Patient With Gout?: Grand Rounds Discussion From Beth Israel Deaconess Medical Center.

Ann Intern Med 2018 Dec;169(11):788-795

Beth Israel Deaconess Medical Center, Boston, Massachusetts (R.B.B., C.C.S., R.H.S., A.T.).

Gout is the most common form of inflammatory arthritis. In 2012, the American College of Rheumatology (ACR) issued a guideline, which was followed in 2017 by one from the American College of Physicians (ACP). The guidelines agree on treating acute gout with a corticosteroid, nonsteroidal anti-inflammatory drug, or colchicine and on not initiating long-term urate-lowering therapy (ULT) for most patients after a first gout attack and in those whose attacks are infrequent (<2 per year). Read More

View Article
December 2018

Antioxidant and xanthine oxidase inhibitory activities of total polyphenols from onion.

Saudi J Biol Sci 2018 Nov 18;25(7):1509-1513. Epub 2017 Aug 18.

School of Materials Science and Engineering, Central South University of Forestry and Technology, Changsha 410004, China.

Onions ( L.) comprise a valuable vegetable crop in many countries. Modern scientific research has shown that onions possess many biological activities, including antibacterial, anticancer, hypoglycemic, hypolipidemic, antiplatelet aggregation, and antioxidant activities. Read More

View Article
November 2018

A Pharmacist-Led Intervention to Improve Gout Medication Adherence and Outcomes with Urate Lowering Therapy: A Site Randomized Trial.

Am J Med 2018 Nov 29. Epub 2018 Nov 29.

Division of Rheumatology, University of Alabama at Birmingham, Birmingham, AL.

Purpose: To test a pharmacist-led intervention to improve gout treatment adherence and outcomes.

Methods: We conducted a site-randomized trial (n=1,463 patients) comparing a one-year, pharmacist-led intervention to usual care in gout patients initiating allopurinol. The intervention was delivered primarily through automated telephone technology. Read More

View Article
November 2018

Impact of Non-Adherence and Flare Resolution on the Cost-Effectiveness of Treatments for Gout: Application of a Linked Pharmacometric/Pharmacoeconomic Model.

Value Health 2018 Dec 26;21(12):1373-1381. Epub 2018 Jul 26.

Centre for Health Economics and Medicines Evaluation, Bangor University, Bangor, UK. Electronic address:

Background: Dual urate-lowering therapy (ULT) with lesinurad in combination with either allopurinol or febuxostat is an option for patients with gout unsuccessfully treated on either monotherapy. Treatment failure is often a result of poor medication adherence. Imperfect adherence in clinical trials may lead to biased estimates of treatment effect and confound the results of cost-effectiveness analyses. Read More

View Article
December 2018

ASSOCIATION OF DYSADIPOKINEMIA WITH TLR4 SERUM CONCENTRATION IN GOUT PATIENTS.

Georgian Med News 2018 Oct(283):59-62

National Pirogov Memorial Medical University, Vinnytsya, Ukraine.

Study objective was to estimate the levels of TLR4 in gout patients and evaluate their association with the dysadipokinemia. The study involved 65 gout patients and 24 healthy individuals. All study subjects proceeded clinical and laboratory examination. Read More

View Article
October 2018

Effectiveness of healthcare educational and behavioral interventions to improve gout outcomes: a systematic review and meta-analysis.

Ther Adv Musculoskelet Dis 2018 Dec 19;10(12):235-252. Epub 2018 Nov 19.

Division of Clinical Immunology and Rheumatology, University of Alabama, Birmingham VA Medical Center, Faculty Office Tower 805B, 510 20th Street South, Birmingham, AL, 35294, USA.

Background: We aimed to systematically review the effectiveness of healthcare behavioral and education interventions for gout patients on clinical outcomes.

Methods: We searched multiple databases to identify trials or observational studies of educational or behavioral interventions in gout. Risk of bias was assessed with the Cochrane tool for randomized control trials (RCTs) and the Newcastle-Ottawa Scale for observational studies. Read More

View Article
December 2018
1 Read

[A woman with a white skin lesion of her toe].

Ned Tijdschr Geneeskd 2018 11 27;163. Epub 2018 Nov 27.

Huisartsenpraktijk Vondelplein, Amersfoort.

A 78-year-old woman visited her general practitioner with a sharply bounded white lesion of her toe. We diagnosed it as gouty tophus, which was confirmed by a high serum urate level. Gout is a chronic disease, characterised by deposition of monosodium urate crystals in joints and tissues. Read More

View Article
November 2018
4 Reads

Dietary factors and risk of gout and hyperuricemia: a meta-analysis and systematic review.

Asia Pac J Clin Nutr 2018 ;27(6):1344-1356

Department of Clinical Nutrition, Tianjin Union Medical Center, China.

Background And Objectives: To evaluate the associations of dietary factors and the risk of gout and hyperuricemia.

Methods And Study Design: PubMed and Embase databases were searched from inception to June 2017 for eligible studies. Nineteen prospective cohort or cross-sectional studies with adequate sample sizes are included, all involving red meat, seafoods, alcohol, fructose, dairy products, soy foods, high-purine vegetables and coffee. Read More

View Article
January 2018
1 Read

Acute effect of soy and soy products on serum uric acid concentration among healthy Chinese men.

Asia Pac J Clin Nutr 2018 ;27(6):1239-1242

School of Public Health, Bengbu Medical College, Anhui, China.

Background And Objectives: Soy products are essential to the daily life of the Chinese population. However, the association between soy products and serum uric acid remains unclear. Better understanding of their relationship could provide food choice information for patients with gout. Read More

View Article
January 2018
1 Read

Characteristics of gout patients according to the laterality of nephrolithiasis: A cross-sectional study using helical computed tomography.

Int J Rheum Dis 2018 Nov 28. Epub 2018 Nov 28.

Department of Internal Medicine, Midorigaoka Hospital, Takatsuki-shi, Japan.

Objective: To clarify the clinical and laboratory characteristics of nephrolithiasis in gout by computed tomography (CT).

Methods: In 350 gout patients, unenhanced CT was performed at the 1st visit to hospital. Calculus density spots exceeding 1 mm in diameter with a CT value >120 Hounsfield units in the kidneys were defined as kidney stones. Read More

View Article
November 2018

Volatile compounds profiling by using Proton Transfer Reaction - Time of Flight - Mass Spectrometry (PTR-ToF-MS). The case study of dark chocolates organoleptic differences.

J Mass Spectrom 2018 Nov 26. Epub 2018 Nov 26.

Centre des Sciences du Goût et de lꞋAlimentation (CSGA), AgroSup Dijon, CNRS, INRA, Université Bourgogne Franche-Comté, F-21000, Dijon, France.

Direct-injection mass spectrometry (DIMS) techniques have evolved into powerful methods to analyse volatile organic compounds (VOCs) without the need of chromatographic separation. Combined to chemometrics, they have been used in many domains to solve samples categorization issues based on volatilome determination. In this paper, different DIMS methods that have largely outperformed conventional electronic noses (e-noses) in classification tasks are briefly reviewed, with an emphasis on food-related applications. Read More

View Article
November 2018
1 Read

Patient-reported gout attack frequency and allopurinol use in general practice in the Netherlands: a prospective observational cohort study protocol.

BMJ Open 2018 Nov 25;8(11):e024335. Epub 2018 Nov 25.

Department of General Practice, Erasmus Medical Center, Rotterdam, The Netherlands.

Introduction: Gout is the most common inflammatory arthritis in the Dutch general practice population and is often managed with long-term uric acid lowering treatment. The clinical relevance of this treatment in preventing gout attacks is unclear.

Primary Research Question: What is the frequency of self-reported gout attacks and what is the effect of allopurinol use in patients diagnosed with gout in general practice?

Methods And Analysis: Adult patients with a diagnostic consultation code for gout in the year 2013, 2014 or 2015 will be invited to participate in this prospective observational cohort study. Read More

View Article
November 2018
10 Reads

The prevalence and factors associated with bone erosion in patients with gout.

Arthritis Care Res (Hoboken) 2018 Nov 26. Epub 2018 Nov 26.

Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Clinical Center for Diabetes, Department of Endocrinology and Metabolism, Shanghai Jiaotong University Affiliated Sixth People's Hospital, Shanghai, China.

Objective: The aim of this study was to determine the prevalence, distribution and factors associated with bone erosion detectable by ultrasound in patients with gout.

Methods: Ultrasound scans were performed in 980 gout patients, and bone erosion was detected. The prevalence and distribution of bone erosion in gout patients were calculated. Read More

View Article
November 2018
2 Reads

Prescribing patterns and healthcare costs of gout.

Curr Med Res Opin 2018 Nov 26:1-18. Epub 2018 Nov 26.

a Department of Pharmacy , College of Pharmacy, Taipei Medical University , Taipei , Taiwan.

The Longitudinal Health Insurance Database (LHID) 2010 was used to identify gout cases and their number of gout flares. Out of 21,376 gout patients, a total of 3,561 (16.7%) had frequent gout flares (> = 3 gout flares/year). Read More

View Article
November 2018
1 Read

Detection of Various Biomarkers and Enzymes via Nanocluster-Based Fluorescence Turn-On Sensing Platform.

Anal Chem 2018 Nov 26. Epub 2018 Nov 26.

The profiling of disease-related biomarkers is an essential procedure for the accurate diagnosis and intervention of metabol-ic disorders. Therefore, the development of ultrasensitive and highly selective fluorogenic biosensors for diverse biomarkers is extremely desirable. There is still a considerable challenge to prepare nanocluster-based fluorescence turn-on probes capa-ble of recognizing multiple biomolecules. Read More

View Article
November 2018
2 Reads

Urate and Osteoarthritis: Evidence For a Reciprocal Relationship.

Joint Bone Spine 2018 Nov 21. Epub 2018 Nov 21.

Rheumatology Section, Department of Medicine, New York Harbor Health Care System, New York Campus, US Department of Veterans Affairs, New York, NY, 10003, USA; Crystal Diseases Study Group, Division of Rheumatology, Department of Medicine, New York University School of Medicine/NYU Langone Health, New York, NY, 10016, USA. Electronic address:

Hyperuricemia is a common condition, and in a subset of patients leads to gout, the most common inflammatory arthritis. Osteoarthritis is the most common form of arthritis overall, and gout and osteoarthritis frequently coexist in the same patient. However, the relationship between the two remains poorly defined. Read More

View Article
November 2018
2 Reads

The Intentional Non-Adherence Scale (INAS): Initial development and validation.

J Psychosom Res 2018 Dec 21;115:110-116. Epub 2018 Oct 21.

Department of Psychological Medicine, University of Auckland, New Zealand.

Objective: Adherence continues to be a major challenge in healthcare but there is still limited understanding of all the factors which can influence adherence behaviour. The present study was designed to identify a range of factors associated with intentional non-adherence and to see if they could be formed into a psychometrically sound scale.

Methods: Patients in three different clinical groups (Hypertension (N = 175); Oncology (N = 115); Gout (N = 196)) were given the new scale together with an adherence self-report and/or biomarker measure. Read More

View Article
December 2018
1 Read

Identification of Glycine Receptor α3 as a Colchicine-Binding Protein.

Front Pharmacol 2018 8;9:1238. Epub 2018 Nov 8.

State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center of Biotherapy, Chengdu, China.

Colchicine (Col) is considered a kind of highly effective alkaloid for preventing and treating acute gout attacks (flares). However, little is known about the underlying mechanism of Col in pain treatment. We have previously developed a customized virtual target identification method, termed IFPTarget, for small-molecule target identification. Read More

View Article
November 2018
7 Reads

Extracellular traps in kidney disease.

Kidney Int 2018 Dec;94(6):1087-1098

Division of Nephrology, Medizinische Klinik und Poliklinik IV, Klinikum der Universität München, LMU München, Germany. Electronic address:

During the past decade the formation of neutrophil extracellular traps (NETs) has been recognized as a unique modality of pathogen fixation (sticky extracellular chromatin) and pathogen killing (cytotoxic histones and proteases) during host defense, as well as collateral tissue damage. Numerous other triggers induce NET formation in multiple forms of sterile inflammation, including thrombosis, gout, obstruction of draining ducts, and trauma. Whether neutrophils always die along with NET release, and if they do die, how, remains under study and is most likely context dependent. Read More

View Article
December 2018
4 Reads

Flavanoids and Anthranquinones as Xanthine oxidase and Monoamine oxidase inhibitors: A new approach towards Inflammation and oxidative stress.

Curr Top Med Chem 2018 Nov 20. Epub 2018 Nov 20.

Faculty of Pharmaceutical Sciences, M. D. University, Rohtak. India.

The development of xanthine oxidase and monoamine oxidase inhibitors led to important breakthroughs in the therapy of oxidative damage, hyperuricemia, gout, neurological, neuropsychiatric disorders and management of reperfusion injury. Drugs obtained from natural sources play an important role in treatment of various pathological disorders and act as lead compound for the discovery of new synthetic drug substances. In this review various pharmacological effects produced by inhibition of xanthine oxidase and monoamine oxidase through natural and synthetic flavanoids as well as anthraquinones are discussed in detail. Read More

View Article
November 2018
4 Reads

Anakinra Therapy for Non-cancer Inflammatory Diseases.

Front Pharmacol 2018 6;9:1157. Epub 2018 Nov 6.

Department of Medicine, Radboud University Medical Center, Nijmegen, Netherlands.

Interleukin-1 (IL-1) is the prototypical inflammatory cytokine: two distinct ligands (IL-1α and IL-1β) bind the IL-1 type 1 receptor (IL-1R1) and induce a myriad of secondary inflammatory mediators, including prostaglandins, cytokines, and chemokines. IL-1α is constitutively present in endothelial and epithelial cells, whereas IL-1β is inducible in myeloid cells and released following cleavage by caspase-1. Over the past 30 years, IL-1-mediated inflammation has been established in a broad spectrum of diseases, ranging from rare autoinflammatory diseases to common conditions such as gout and rheumatoid arthritis (RA), type 2 diabetes, atherosclerosis, and acute myocardial infarction. Read More

View Article
November 2018
6 Reads

Three-dimensional cancer cell culture in high-yield multiscale scaffolds by shear spinning.

Biotechnol Prog 2018 Nov 20. Epub 2018 Nov 20.

Inst. of Structural and Molecular Biology, University College London, London, WC1E 6BT, U.K.

Polymeric scaffolds comprising two size scales of microfibers and submicron fibers can better support three-dimensional (3D) cell growth in tissue engineering, making them an important class of healthcare material. However, a major manufacturing barrier hampers their translation into wider practical use: scalability. Traditional production of two-scale scaffolds by electrospinning is slow and costly. Read More

View Article
November 2018
6 Reads

Severe Disseminated Gonococcal Infection with Polyarticular Gout: Two Cases in Older Travelers.

Am J Trop Med Hyg 2018 Nov 19. Epub 2018 Nov 19.

Global and Tropical Health Division, Menzies School of Health Research, Darwin, Australia.

Two male travelers with histories of gout and hazardous alcohol consumption, presented with a triad of severe culture-positive disseminated gonococcal infection, crystal-positive polyarticular gout, and gonococcal soft tissue collections, following unprotected sexual contact in The Philippines. Both men initially attributed symptoms to gout, since their usual joints were affected, but clinical deterioration occurred with self-administration of anti-inflammatory agents alone. The clinical courses were severe and protracted, requiring aggressive management of infection with prolonged intravenous antimicrobials and repeated surgery, and prolonged anti-inflammatory agents for gout. Read More

View Article
November 2018
2 Reads

Should we treat patients with radiologically isolated syndrome (RIS)? No.

Authors:
O Gout

Rev Neurol (Paris) 2018 Dec 16;174(10):693-695. Epub 2018 Nov 16.

Department of neurology, fondation ophtalmologique A.de-Rothschild, 29, rue Manin, 75019 Paris, France. Electronic address:

View Article
December 2018
1 Read

Impact of Olfactory Priming on Food Intake in an Alzheimer's Disease Unit.

J Alzheimers Dis 2018 Nov 12. Epub 2018 Nov 12.

Centre des Sciences du Goût et de l'Alimentation, AgroSup Dijon, CNRS, INRA, Université Bourgogne Franche-Comté, Dijon, France.

Alzheimer's disease (AD) is often associated with feeding difficulties and changes in eating behavior with may lead to malnutrition. In French nursing homes, AD patients may live in special care units that better meet dementia residents' needs. However, meals are often delivered to AD patients by using meal trays coming from central kitchens. Read More

View Article
November 2018
8 Reads

Diagnostic Imaging and Management of Common Intra-articular and Peri-articular Soft Tissue Tumors and Tumorlike Conditions of the Knee.

J Knee Surg 2018 Nov 16. Epub 2018 Nov 16.

Department of Orthopedic Surgery, Wake Forest University School of Medicine, Winston-Salem, North Carolina.

Intra-articular (IA) and peri-articular (PA) tumors of the knee are frequently encountered by orthopaedic surgeons. Nonetheless, due to the possibility of great morbidity and potential mortality, it is important to recognize and differentiate between benign and malignant lesions in a timely manner. Therefore, the purpose of this article is to provide a concise, practical, and updated review of commonly encountered IA and PA tumors including intratendinous gout, synovial chondromatosis, schwannoma, pigmented villonodular synovitis, and synovial sarcoma, and a detailed description of differentiating features to include various imaging modalities. Read More

View Article
November 2018
2 Reads

Prevalence of malnutrition using harmonized definitions in older adults from different settings - A MaNuEL study.

Clin Nutr 2018 Nov 3. Epub 2018 Nov 3.

Leibniz Institute for Prevention Research and Epidemiology - BIPS, Achterstr. 30, 28359 Bremen, Germany.

Background & Aims: Malnutrition is widespread among older people and related to poor outcome. Reported prevalences vary widely, also because of different diagnostic criteria used. This study aimed to describe prevalences in several populations of older persons in different settings using harmonized definitions. Read More

View Article
November 2018
7 Reads

The Challenges of Approaching and Managing Gout.

Rheum Dis Clin North Am 2019 Feb;45(1):145-157

Division of Rheumatology, Hospital for Special Surgery, 535 East 70th Street, Suite 848G, New York, NY 10021, USA. Electronic address:

Despite many effective treatments for gout, its management remains a challenge internationally. Options for optimizing gout management may differ in different practice sizes and settings. Gout incidence is rising and it continues to be associated with increased mortality. Read More

View Article
February 2019
2 Reads

Antioxidant properties of citric acid interfere with the uricase-based measurement of circulating uric acid.

J Pharm Biomed Anal 2018 Nov 9;164:460-466. Epub 2018 Nov 9.

Department of Internal Medicine, Division of Rheumatology, University of Nebraska Medical Center, Omaha, NE, USA; Veteran Affairs Nebraska-Western Iowa Health Care System, Omaha, NE, USA.

Background: Circulating uric acid (UA) is an important biomarker, not only in the detection and management of gout, but also in assessing the risk of related comorbidity. The impact of collection methods on clinical UA measurements has been the subject of limited study. After observing significant differences between UA concentrations of blood samples obtained by different collection tubes, we began examining the effects of exogenous tube components on measured UA concentrations. Read More

View Article
November 2018
24 Reads

Ethanol upregulates the P2X7 purinergic receptor in human macrophages.

Fundam Clin Pharmacol 2018 Nov 17. Epub 2018 Nov 17.

INSERM, INRA, CHU Rennes, Institut NuMeCan (Nutrition, Metabolism and Cancer), Univ Rennes, F-35000, Rennes, France.

Alcohol consumption is considered to be the third leading cause of death in the United States. In addition to its direct toxicity, ethanol has two contrasting effects on the immune system: the nucleotide oligomerization domain-like receptor pyrin domain-containing-3 (NLRP3) inflammasome is inhibited by acute ethanol exposure but activated by chronic ethanol exposure. Purinergic receptors (especially the P2X7 receptor) are able to activate the NLRP3 inflammasome and are involved in many ethanol-related diseases (such as gout, pulmonary fibrosis, alcoholic steatohepatitis, and certain cancers). Read More

View Article
November 2018
7 Reads

Could the environmental toxicity of diclofenac in vultures been predictable if preclinical testing methodology were applied?

Environ Toxicol Pharmacol 2018 Dec 26;64:181-186. Epub 2018 Oct 26.

Veterinary Pharmacology/Toxicology, Department of Paraclinical Sciences, University of Pretoria, Onderstepoort, South Africa; University of Pretoria Biotechnology Research Centre, South Africa. Electronic address:

Diclofenac, a non-steroidal anti-inflammatory pharmaceutical agent was responsible for the death of millions of Gyps vulture's in the Indian sub-region with the safety of the other non-steroidal anti-inflammatory drugs (NSAIDs) being questionable. With preclinical safety testing not well established for avian species unlike for mammalian and environmental toxicity, we ask the question if a preclinical model could have predicted the toxic effect of the drug. For this study, we test an Organisation for Economic Co-operation and Development (OECD) guideline 223 for assessing the acute toxic potential of pesticides in birds by exposing three avian species to the drug. Read More

View Article
December 2018
3 Reads

Hyperuricemia-associated Mesoamerican Nephropathy: Case Report and Review of Literature.

Cureus 2018 Sep 11;10(9):e3282. Epub 2018 Sep 11.

Nephrology Unit, Howard University Hospital, Washington, D.C., USA.

Mesoamerican nephropathy (MeN), formerly called chronic kidney disease of unknown cause (CKDu), refers to chronic kidney disease (CKD) that presents in young and middle-aged Central Americans in the absence of any clear etiology. MeN is a relatively new diagnosis with rapidly rising prevalence in specific regions of El Salvador and Nicaragua, Guatemala, and Costa Rica. It is seldom associated with hyperuricemia. Read More

View Article
September 2018
1 Read

Hepatic Safety of Febuxostat Compared with Allopurinol in Gout Patients with Fatty Liver Disease.

J Rheumatol 2018 Nov 15. Epub 2018 Nov 15.

From the Department of Rheumatology, University of Ulsan College of Medicine, Asan Medical Center; Department of Radiology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea. J.S. Lee, MD, Department of Rheumatology, Asan Medical Center; J. Won, MD, Department of Rheumatology, Asan Medical Center; O.C. Kwon, MD, Department of Rheumatology, Asan Medical Center; S.S. Lee, MD, PhD, Department of Radiology, Asan Medical Center; J.S. Oh, MD, PhD, Clinical Research Center, University of Ulsan College of Medicine, Asan Medical Center; Y.G. Kim, MD, PhD, Department of Rheumatology, Asan Medical Center; C.K. Lee, MD, PhD, Department of Rheumatology, Asan Medical Center; B. Yoo, MD, PhD, Department of Rheumatology, Asan Medical Center; S. Hong, MD, PhD, Department of Rheumatology, Asan Medical Center. Address correspondence to Dr. S. Hong, Division of Rheumatology, University of Ulsan College of Medicine, Asan Medical Center 88, Olympic-ro 43-gil, Songpa-gu, Seoul 05505, Korea. E-mail: Accepted for publication October 4, 2018.

Objective: Febuxostat has superior renal safety to allopurinol, but data on its hepatic safety are limited. Thus we compared the hepatotoxicity of febuxostat and allopurinol, and the clinical factors associated with hepatotoxicity, in patients with gout and fatty liver disease (FLD).

Methods: We included gout patients treated with allopurinol or febuxostat who were diagnosed with fatty liver based on ultrasonography or computed tomography. Read More

View Article
November 2018
2 Reads

Utility of Anakinra in Acute Crystalline Diseases: A Retrospective Study Comparing a University Hospital with a Veterans Affairs Medical Center.

J Rheumatol 2018 Nov 15. Epub 2018 Nov 15.

From the Division of Arthritis and Rheumatic Diseases, Oregon Health & Science University; Rheumatology Section, Veterans Affairs (VA) Portland Health Care System, Portland, Oregon, USA. J. Desmarais, MD, Division of Arthritis and Rheumatic Diseases, Oregon Health & Science University; C.Q. Chu, MD, PhD, Division of Arthritis and Rheumatic Diseases, Oregon Health & Science University, and Rheumatology Section, VA Portland Health Care System. Address correspondence to Dr. J. Desmarais, 3181 SW Sam Jackson Park Road, Mail Code OP 09, Portland, Oregon 97239, USA. E-mail: Accepted for publication August 15, 2018.

Objective: To evaluate the efficacy and safety of anakinra in inpatient management of acute gout and pseudogout.

Methods: Hospitalized patients with acute gout (n = 77) or pseudogout (n = 11) or both (n = 3) were analyzed for response to anakinra and adverse effects.

Results: Half of all patients had comorbidities limiting the treatment choice. Read More

View Article
November 2018
2 Reads

CHARACTERIZATION OF STEREOSELECTIVE METABOLISM, INHIBITORY EFFECT ON URIC ACID UPTAKE TRANSPORTERS, AND PHARMACOKINETICS OFLESINURAD ATROPISOMERS.

Drug Metab Dispos 2018 Nov 15. Epub 2018 Nov 15.

Ardea Biosciences, Inc.,

Lesinurad (Zurampic), a selective inhibitor of uric acid reabsorption transporters used clinically for the treatment of gout, is a racemate of two atropisomers. The objectives were to evaluate the stereoselectivity of the metabolism, the inhibitory potency on (URAT1 and OAT4), and the clinical pharmacokinetics of the two atropisomers. In vitro incubations with human liver microsomes (HLM) or recombinant CYP2C9 and CYP3A4 and hydrolases were carried out to characterize metabolic stereoselectivity for the formation of two major metabolites in human, M3 (hydroxylation) and M4 (a dihydrodiol metabolite). Read More

View Article
November 2018
1 Read

Controversies in the treatment of gout.

Vnitr Lek 2018 ;64(7-8):753-761

The authors discuss current options on the treatment of gout (acute gout attack, prophylaxis, management of hypouricemia) and asymptomatic hyperuricemia. They highlight the differences in individual guidelines in terms of the spectrum of drugs used, their preferences, dosing, dose titration, and goals of treatment as well as different positions over asymptomatic hyperuricemia. Further, the authors provide an overview of latest concepts related to uric acid and its association with some neurologic and cardiovascular diseases. Read More

View Article
January 2018
1 Read

Gout and dementia in the elderly: a cohort study of Medicare claims.

BMC Geriatr 2018 Nov 14;18(1):281. Epub 2018 Nov 14.

Department of Medicine at School of Medicine, University of Alabama at Birmingham, 1720 Second Ave. South, Birmingham, AL, 35294-0022, USA.

Background: Conflicting data in the literature raise the question whether gout, independent of its treatment, increases the risk of dementia in the elderly. Our objective was to assess whether gout in older adults is associated with the risk of incident dementia.

Methods: We used the 5% Medicare claims data for this observational cohort study. Read More

View Article
November 2018
1 Read

Serum urate levels and therapy in adults treated with long-term dialysis: a retrospective cross-sectional study.

Intern Med J 2018 Nov 13. Epub 2018 Nov 13.

Department of Rheumatology, Immunology and Allergy, Christchurch Hospital.

Background: To estimate the point prevalence of gout, gout treatment, and achievement of target serum urate (SU) among adults treated with long-term dialysis.

Methods: Three secular cohorts of adults receiving dialysis for at least 90 days on 1 February 2017, 1 January 2016 and 1 January 2015 were identified. Medical records were reviewed for SU concentrations. Read More

View Article
November 2018
3 Reads

Impact of pegloticase on patient outcomes in refractory gout: current perspectives.

Open Access Rheumatol 2018 18;10:141-149. Epub 2018 Oct 18.

Centre for Rheumatology, University College London, London, UK.

Gout is currently the most frequent cause of inflammatory arthritis worldwide and is responsible for poor health-related quality of life and loss of work productivity. It is caused by high levels of serum urate, leading to the deposition of monosodium urate crystals in joints and soft tissues. This condition is associated with acute flares and, if untreated or refractory, chronic and potentially destructive arthritis and tophi formation. Read More

View Article
October 2018
6 Reads

Effect of fenofibrate on uric acid level in patients with gout.

Sci Rep 2018 Nov 13;8(1):16767. Epub 2018 Nov 13.

Department of Rheumatology, Ajou University School of Medicine, 164 Worldcup-ro, Yeongtong-gu, Suwon, 16499, Korea.

Gout is a chronic disease associated with deposition of monosodium urate crystals and accompanied by diabetes, hypertension, and dyslipidemia. Hypertriglyceridemia is common among patients with gout, and fenofibrate is usually used to reduce triglyceride levels. The aim of this study is to determine the effect of uric acid reduction by fenofibrate in patients with gout administered uric acid lowering agents (viz. Read More

View Article
November 2018
10 Reads

Clinical manifestations and molecular aspects of phosphoribosylpyrophosphate synthetase superactivity in females.

Rheumatology (Oxford) 2018 Jul;57(7):1180-1185

Institute of Inherited Metabolic Disorders, First Faculty of Medicine, Charles University, Prague, Czech Republic.

Objectives: Phosphoribosylpyrophosphate synthetase (PRPS1) superactivity is an X-linked disorder characterized by urate overproduction Online Mendelian Inheritance in Man (OMIM) gene reference 300661. This condition is thought to rarely affect women, and when it does, the clinical presentation is mild. We describe a 16-year-old African American female who developed progressive tophi, nephrolithiasis and acute kidney failure due to urate overproduction. Read More

View Article
July 2018
5 Reads

Restricting maintenance allopurinol dose according to kidney function in patients with gout is inappropriate!

Br J Clin Pharmacol 2018 Nov 12. Epub 2018 Nov 12.

Department of Medicine, University of Auckland, Auckland, New Zealand.

View Article
November 2018
1 Read

Gout: Update on Dual-Energy Computed Tomography with Emphasis on Artifact Identification.

Curr Rheumatol Rep 2018 Nov 13;20(12):86. Epub 2018 Nov 13.

Department of Radiology, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL, 32224, USA.

Purpose Of Review: Gout is the most common inflammatory arthritis and is increasing in prevalence and incidence in many countries worldwide. Accurate diagnosis is important to direct treatment that may include chronic medication. Burden quantification and treatment monitoring are key in the effective care of patients with gout. Read More

View Article
November 2018
3 Reads