21,046 results match your criteria Gout

Simulation of Febuxostat Pharmacokinetics in Healthy Subjects and Patients with Impaired Kidney Function Using Physiologically Based Pharmacokinetic Modeling.

Biopharm Drug Dispos 2022 Jun 24. Epub 2022 Jun 24.

Center of Clinical Pharmacology, the Second Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou, Zhejiang, China.

Febuxostat is recommend by the American College of Rheumatology Gout Management Guidelines as a first-line therapy for lowering the level of urate in patients with gout. At present, this drug is being prescribed mainly based on the clinical experience of doctors. The potential effects of clinical and demographic variables on the bioavailability and therapeutic effectiveness of febuxostat are not being considered. Read More

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Insight into the Epidemiology and Evolutionary History of Novel Goose Astrovirus-Associated Gout in Goslings in Southern China.

Viruses 2022 Jun 15;14(6). Epub 2022 Jun 15.

College of Animal Science & Technology, Zhongkai University of Agriculture and Engineering, Guangzhou 510225, China.

A novel gout disease, characterized by visceral urate deposition with high-mortality, with outbreaks in goslings in China since 2016 was caused by a novel goose astrovirus (GoAstV) and resulted in serious economic loss. However, the epidemiology and variation of the GoAstV in goslings in southern China and its evolutionary history as well as the classification of the GoAstV are unclear. In the present study, systematic molecular epidemiology, and phylogenetic analyses of the GoAstV were conducted to address these issues. Read More

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The Effect of Gout on Thyroid Cancer Incidence: A Nested Case-Control Study Using a National Health Screening Cohort.

J Pers Med 2022 May 27;12(6). Epub 2022 May 27.

Bundang CHA Medical Center, Department of Otorhinolaryngology-Head and Neck Surgery, CHA University, Seongnam 13488, Korea.

In this study, we investigated the risk of thyroid cancer in patients with gout. Participants ≥40 years old in the Korean National Health Insurance Service-Health Screening Cohort were investigated. A total of 5844 patients with thyroid cancer were paired with 23,376 comparison participants (no history of thyroid cancer) to build the nested case-control study. Read More

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Retinal Microvascular Changes in Familial Hypercholesterolemia: Analysis with Swept-Source Optical Coherence Tomography Angiography.

J Pers Med 2022 May 26;12(6). Epub 2022 May 26.

Cardiology Department, University Hospital, 21000 Dijon, France.

Familial hypercholesterolemia (FH) is a common but underdiagnosed genetic disorder affecting cholesterol metabolism, leading to atherosclerotic disease. The relationship between retinal microvascular changes and the presence of atheroma in patients with FH (FH group), and in comparison to volunteers without FH (CT group), needs further investigation. This cross-sectional study was conducted in a university hospital between October 1, 2020 and May 31, 2021. Read More

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Prevalence of Patients Receiving Urate-Lowering Medicine in Greenland and Denmark: A Cross-Sectional Case-Control Study.

Int J Environ Res Public Health 2022 Jun 13;19(12). Epub 2022 Jun 13.

Steno Diabetes Center Greenland, Queen Ingrid's Hospital, Nuuk 3900, Greenland.

This study estimates the age- and sex-specific prevalence of patients receiving urate-lowering therapy (ULT) in Greenland and compares the results with estimates in Denmark. Characteristics of patients receiving ULT in Greenland were compared to age- and sex-matched controls. The study was designed as a cross-sectional case-control study based on nationwide data from medical and population registers in Greenland and Denmark. Read More

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Risk factors of urinary calculi in men with gout.

Clin Rheumatol 2022 Jun 24. Epub 2022 Jun 24.

Department of Family Medicine and Division of General Internal Medicine, Department of Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, State Key Laboratory of Complex Severe and Rare Diseases (Peking Union Medical College Hospital), Shuaifuyuan No.1, Dongcheng District, Beijing, 100730, China.

Objective: To investigate risk factors of urinary calculi in men with gout.

Method: A study was conducted at a tertiary hospital in Beijing from October 2016 to January 2020. Male gouty patients were included. Read More

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Hypouricemic Effect of Submerged Culture of in Potassium Oxonate-Induced Hyperuricemic Rats.

Metabolites 2022 Jun 16;12(6). Epub 2022 Jun 16.

Department of Food Science, National Taiwan Ocean University, Keelung 20224, Taiwan.

Hyperuricemia is a disease caused by a high level of uric acid in the blood. It is an important factor for gout and may be linked to renal and hepatic failure. The objective of this study was to investigate the hypouricemic effects of submerged culture of . Read More

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Increased risk of cardiovascular events and death in the initial phase after discontinuation of febuxostat or allopurinol: another story of the CARES trial.

RMD Open 2022 Jun;8(2)

Rheumatology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, The Republic of Korea

Objectives: The Cardiovascular Safety of Febuxostat or Allopurinol in Patients with Gout (CARES) trial suggested a higher risk of cardiovascular (CV) death from febuxostat than from allopurinol. However, a significant number of patients died after discontinuation of febuxostat or allopurinol. We investigated whether major adverse cardiovascular events (MACE) and CV death were increased because of discontinuation of febuxostat or allopurinol using the CARES trial data. Read More

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Upregulated expression of FFAR2 and SOC3 genes is associated with Gout.

Rheumatology (Oxford) 2022 Jun 22. Epub 2022 Jun 22.

Academic Rheumatology, School of Medicine, University of Nottingham, Nottingham, UK.

Objective: To examine the expression of Free fatty acid receptor 2 (FFAR2) and Suppressor of cytokine signalling 3 (SOCS3) genes in asymptomatic hyperuricaemia (AH), AH with monosodium urate (MSU) crystal deposition, inter-critical gout, and gout flare.

Method: Study participants (n = 120) comprised 34 people with serum urate (SU) <360 micromol/l, 69 with AH +/- MSU crystal deposition, and 17 with a gout flare. Sixteen of the 17 patients with a gout flare attended a second visit 6-12 weeks later. Read More

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Effect modification by contextual factors of urate-lowering therapy on serum urate in people with gout: A systematic review with meta-regression analysis.

Semin Arthritis Rheum 2022 Jun 15;56:152049. Epub 2022 Jun 15.

Department of Internal Medicine, Division of Rheumatology, Maastricht University Medical Center, P.O. Box 5800, Maastricht, AZ 6202, the Netherlands; Care and Public Health Research Institute (CAPHRI), Maastricht University, Maastricht, the Netherlands.

Objective: To synthesize evidence of the effect of contextual factors (CFs) on efficacy of urate-lowering therapy (ULT) on serum urate (SU) as outcome in gout patients.

Methods: Randomised controlled trials (RCTs) from (updated) Cochrane reviews were the starting point. RCTs were included if they explored the role of any CF on efficacy of ULT on SU in gout patients. Read More

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In vitro and in silico xanthine oxidase inhibitory activities of 3-aryl-2-thioxo-2,3-dihydroquinazolin-4(1H)-one derivatives.

Med Chem 2022 Jun 20. Epub 2022 Jun 20.

H. E. J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi-75270, Pakistan.

Background: Hyperuricemia is associated with several disease conditions, such as atherosclerosis, arthritis, kidney stones, and many others. Xanthine oxidase (XO), is an enzyme catalyzes the conversion of xanthine to uric acid. Hence, XO is a major therapeutic drug target in the treatment of hyperuricemia, and associated disorders. Read More

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Prevalence of Hyperuricemia and the Relationship Between Serum Uric Acid and Hypertension in New Onset Diabetic Patients: A Cross-Sectional Indian Study.

Diabetes Metab Syndr Obes 2022 14;15:1809-1817. Epub 2022 Jun 14.

Department of Extension and Communication Management & Home Science, Acharya Narendra Deva University of Agriculture and Technology, Ayodhya, Uttar Pradesh, India.

Objective: Prevalence of hyperuricemia (HU) is increasing and it is associated with hypertension, metabolic syndrome, diabetes mellitus (DM), obesity, chronic kidney disease, gout and cardiovascular disease. Elevated level of serum uric acid (SUA) has been shown to be associated with hypertension and diabetes in many countries but there is lack of evidence from India. The aim of this study is to know the prevalence of HU and to know the relationship between SUA and hypertension in newly onset DM. Read More

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Synergistic Impacts of Seed Extract and Allopurinol against Experimental Hyperuricemia.

Biomed Res Int 2022 11;2022:2824535. Epub 2022 Jun 11.

KM Science Research Division, Korea Institute of Oriental Medicine, 1672 Yuseong-daero, Yuseong-gu, Daejeon 34054, Republic of Korea.

In traditional medicine, Miquel seed has been used to treat gout and hyperuricemia-related symptoms by enhancing kidney functions. Allopurinol is the most commonly used drug to treat hyperuricemia; however, the drug has many adverse effects. Combining allopurinol with another compound could reduce the need for high doses and result in improved safety. Read More

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Evaluation of the safety and efficacy of a Fuling-Zexie decoction for people with asymptomatic hyperuricemia: protocol for a prospective, double-blinded, randomized, placebo-controlled clinical trial.

Trials 2022 Jun 20;23(1):517. Epub 2022 Jun 20.

Department of Rheumatology, Guangdong Provincial Hospital of Chinese Medicine, No. 55 of Neihuanxi Road, Higher Education Mega Center, Guangzhou, 510006, China.

Background: Hyperuricemia increases the risk of gout and cardiovascular complications, and how to manage asymptomatic hyperuricemia is controversial. Randomized controlled trials and comparative studies are needed to guide management and treatment. Studies show that Chinese medicine can decrease uric acid through multiple targets, but many of these studies have been conducted in animals because of the lack of a consistent prescription and mechanism. Read More

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Costochondral gout.

CMAJ 2022 Jun;194(24):E845

Department of Diagnostic and Generalist Medicine, Dokkyo Medical University Hospital, Tochigi, Japan

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Gout and susceptibility and severity of COVID-19: a bidirectional Mendelian randomization analysis.

J Infect 2022 Jun 17. Epub 2022 Jun 17.

Department of Thoracic Oncology and Surgery, China State Key Laboratory of Respiratory Disease & National Clinical Research Center for Respiratory Disease, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China. Electronic address:

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Erosive Tophaceous Gouty Arthropathy of the Hand: A Case Report.

S D Med 2022 May;75(5):216-219

Sanford Orthopedics and Sports Medicine, Sioux Falls, South Dakota.

The presence of tophaceous gout in the hand is a classic finding seen in uncontrolled gout. Occasionally gouty tophi can be the initial physical finding in asymptomatic hyperuricemia. Composed of monosodium urate (MSU) crystals, gouty tophi can cause significant soft tissue and joint pathology. Read More

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Gout increases length of stay in patients hospitalized for heart failure exacerbation.

Ther Adv Musculoskelet Dis 2022 14;14:1759720X221102853. Epub 2022 Jun 14.

Division of Rheumatology, Columbia University Irving Medical Center, 630 West 168th Street, Suite 3-450, New York, NY 10032, USA.

Background: It is unclear whether patients with a history of gout have longer hospitalizations in general, or only when suffering a flare. This study examines the effect of gout diagnosis and gout flare on the length of stay (LoS) in patients admitted for heart failure (HF) exacerbation.

Methods: We conducted a matched retrospective cohort study and searched electronic medical records for patients admitted for HF with a prior diagnosis of gout from 1 July 2012 to 30 June 2017 and matched them to patients admitted for HF without gout. Read More

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Risk factors associated with hospitalization in patients with asymptomatic or mild COVID-19 in public accommodation facilities in Tokyo.

J Infect Chemother 2022 Jun 13. Epub 2022 Jun 13.

The Jikei University School of Medicine, 3-25-8, Nishi-Shimbashi, Minato-ku, Tokyo, 105-8461, Japan.

Introduction: In Japan, patients with coronavirus disease 2019 (COVID-19) who do not require medical intervention are provided care in recovery accommodation facilities (RAFs). However, some patients may require hospitalization if their symptoms become more severe during their stay. We conducted an observational study using epidemiological data of patients with COVID-19 admitted to RAFs in Tokyo. Read More

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RvD1 disrupts nociceptor neuron and macrophage activation, and neuroimmune communication reducing pain and inflammation in gouty arthritis in mice.

Br J Pharmacol 2022 Jun 18. Epub 2022 Jun 18.

Laboratory of Pain, Inflammation, Neuropathy, and Cancer, Department of Pathology, Centre of Biological Sciences, Londrina State University, Londrina, Paraná, Brazil.

Background And Purpose: Gouty arthritis is characterised by an intense inflammatory response to monosodium urate crystals (MSU), which induces severe pain. Current therapies are often ineffective in reducing gout-related pain. Resolvin D1 (RvD1) is a specialised pro-resolving lipid mediator with anti-inflammatory and analgesic proprieties. Read More

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Birefringent Crystals Deposition and Inflammasome Expression in Human Atheroma Plaques by Levels of Uricemia.

Joint Bone Spine 2022 Jun 14:105423. Epub 2022 Jun 14.

Rheumatology Unit, Dr. Balmis General University Hospital-ISABIAL, Alicante, Spain; Clinical Medicine Department, Miguel Hernández University, San Juan de Alicante, Spain.

Objective: To verify the monosodium urate (MSU) crystal deposition in artery walls following a structure assessment and to assess NLRP3 inflammasome expression in human atheroma plaques by levels of uricemia.

Methods: Patients with peripheral arterial disease who were candidates for amputation were recruited and classified as normouricemic or hyperuricemic. During surgery, an artery segment from the amputated limb was sampled, divided and fixed separately by cryo-embedding, 100% ethanol or Glyo-fixx. Read More

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Caffeic acid phenethyl ester alleviated hypouricemia in hyperuricemic mice through inhibiting XOD and up-regulating OAT3.

Phytomedicine 2022 Aug 8;103:154256. Epub 2022 Jun 8.

Guangdong Provincial Key Laboratory of Microbial Safety and Health, Key Laboratory of Agricultural Microbiomics and Precision Application of the Ministry of Agriculture and Rural Affairs and State Key Laboratory of Applied Microbiology Southern China, Institute of Microbiology, Guangdong Academy of Sciences, Guangzhou 510070, China.

Background: Hyperuricemia is characterized with high serum uric acids (SUAs) and directly causes suffering gout. Caffeic acid phenethyl ester (CAPE) is widely included in dietary plants and especially propolis of honey hives.

Hypothesis/purpose: Since CAPE exerts a property resembling a redox shuttle, the hypothesis is that it may suppress xanthine oxidase (XOD) and alleviate hyperuricemia. Read More

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TET2-mutant clonal hematopoiesis and risk of gout.

Blood 2022 Jun 17. Epub 2022 Jun 17.

Howard Hughes Medical Institute, United States.

Gout is a common inflammatory arthritis caused by precipitation of monosodium urate (MSU) crystals in individuals with hyperuricemia. Acute flares are accompanied by secretion of pro-inflammatory cytokines, including interleukin-1 beta (IL-1B). Clonal hematopoiesis of indeterminate potential (CHIP) is an age-related condition predisposing to hematologic cancers and cardiovascular disease. Read More

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Taxifolin blocks monosodium urate crystal-induced gouty inflammation by regulating phagocytosis and autophagy.

Inflammopharmacology 2022 Jun 16. Epub 2022 Jun 16.

Key Laboratory of Traditional Chinese Korean Medicine Research (Yanbian University) of State Ethnic Affairs Commission, College of Pharmacy, Yanbian University, Yanji, 133002, Jilin, China.

Gout is a chronic disease caused by monosodium urate (MSU) crystal deposition in the joints and surrounding tissues. We examined the effects of Taxifolin, a natural flavonoid mainly existing in vegetables and fruits, on MSU-induced gout. Pretreatment with Taxifolin significantly reduced IL-1β, Caspase-1 and HMGB1 levels, upregulation of autophagy-related protein, LC3, as well as improved phagocytosis of macrophages. Read More

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Examining an Association of Single Nucleotide Polymorphisms with Hyperuricemia in Chinese Flight Attendants.

Pharmgenomics Pers Med 2022 8;15:589-602. Epub 2022 Jun 8.

Center for Precision Medicine, School of Medicine and School of Biomedical Sciences, Huaqiao University, Xiamen, Fujian, People's Republic of China.

Background: Both genetic and environmental factors strongly affect serum uric acid (SUA) concentrations. The incidence of hyperuricemia tends to be younger in the Chinese population. In particular, we have found a high prevalence of hyperuricemia among Chinese flight attendants, aged from 20 to 40, in our survey. Read More

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Systemic lupus erythematosus dysregulates the expression of long noncoding RNAs in placentas.

Arthritis Res Ther 2022 Jun 14;24(1):142. Epub 2022 Jun 14.

Department of Obstetrics and Gynecology, University of Wisconsin-Madison, Madison, WI, 53715, USA.

Background: Systemic lupus erythematosus (SLE) can cause placental dysfunctions, which may result in pregnancy complications. Long noncoding RNAs (lncRNAs) are actively involved in the regulation of immune responses during pregnancy. The present study aimed to determine the lncRNA expression profiles in placentas from women with SLE to gain new insights into the underlying molecular mechanisms in SLE pregnancies. Read More

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High prevalence of chondrocalcinosis and frequent comorbidity with calcium pyrophosphate deposition disease in patients with seronegative rheumatoid arthritis.

RMD Open 2022 Jun;8(2)

Ruhr University Bochum, Bochum, Germany

Background: The crystal-induced calcium pyrophosphate deposition disease (CPPD) clinically appearing as pseudogout differs from the mere radiographic finding of chondrocalcinosis (CC) but may cause symptoms resembling rheumatoid arthritis (RA).

Objective: To study the prevalence of CPPD and CC in rheumatic diseases focusing on differences between seropositive and seronegative RA.

Patients And Methods: In a retrospective study design, we analysed records and radiographs of consecutive new patients presenting to our centre between January 2017 and May 2020. Read More

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Evidence of Magnon-Mediated Orbital Magnetism in a Quasi-2D Topological Magnon Insulator.

Nano Lett 2022 Jun 14. Epub 2022 Jun 14.

Department of Electrical and Computer Engineering, Auburn University, Auburn, Alabama 36849, United States.

We explore spin dynamics in Cu(1,3-bdc), a quasi-2D topological magnon insulator. The results show that the thermal evolution of the Landé factor () is anisotropic: decreases while increases with increasing temperature . Moreover, the anisotropy of the factor (Δ) and the anisotropy of saturation magnetization (Δ) are correlated below 4 K, but they diverge above 4 K. Read More

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