17,529 results match your criteria Gout


Causative Pathogens of Endophthalmitis after Intravitreal Anti-VEGF Injection: An International Multicenter Study.

Ophthalmologica 2019 Mar 19:1-9. Epub 2019 Mar 19.

Division of Ophthalmology, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv,

Purpose: The main objective of this study was to investigate the microbiological spectrum of endophthalmitis after anti-VEGF injections and to compare streptococcal with non-streptococcus-associated cases with regard to baseline characteristics and injection procedure.

Methods: Retrospective, international multicenter study of patients with culture-positive endophthalmitis after intravitreal anti-VEGF injection at 17 different retina referral centers.

Results: Eighty-three cases with 87 identified pathogens were included. Read More

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http://dx.doi.org/10.1159/000496942DOI Listing

Urate Bulla: a Rare Manifestation of Gout.

J Gen Intern Med 2019 Mar 18. Epub 2019 Mar 18.

Emergency Department, San Francisco VA Medical Center, San Francisco, CA, USA.

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http://dx.doi.org/10.1007/s11606-019-04864-4DOI Listing

Gout and sexual function: patient perspective of how gout affects personal relationships and intimacy.

BMC Rheumatol 2019 28;3. Epub 2019 Feb 28.

1Medicine Service, Birmingham VA Medical Center, 700 19th St S, Birmingham, AL 35233 USA.

Background: In absence of previous studies, we assessed how gout impacts relationship and intimacy with spouse/significant other.

Methods: We enrolled a convenience sample of consecutive patients with doctor-diagnosed gout from a community-based outpatient clinic. Nominal groups were conducted until saturation was achieved. Read More

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http://dx.doi.org/10.1186/s41927-019-0056-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396531PMC
February 2019

Asymptomatic hyperuricemia and coronary flow reserve in patients with metabolic syndrome.

BMC Rheumatol 2018 20;2:17. Epub 2018 Jun 20.

Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, 1620 Tremont St, Suite 3030, Boston, MA 02120 USA.

Background: Patients with metabolic syndrome (MetS) are at increased risk of asymptomatic hyperuricemia (i.e., elevated serum uric acid (SUA) level without gout) and cardiovascular disease. Read More

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http://dx.doi.org/10.1186/s41927-018-0027-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6390615PMC

An evaluation of gout visits in the United States for the years 2007 to 2011.

BMC Rheumatol 2018 30;2:14. Epub 2018 May 30.

Campbell University College of Pharmacy & Health Sciences, 180 Main Street PO Box 1090, Buies Creek, NC 27506 USA.

Background: This study analyzed visits for and factors associated with gout and gout medication treatment trends for the years 2007-2011 in the United States given the introduction of febuxostat, the first new treatment option for gout in over 40 years, which was introduced to the market in 2009.

Methods: This study was a retrospective, cross-sectional, observational study of patients age 20 and older seen by providers who participated in the National Ambulatory Medical Care Survey (NAMCS), the National Hospital Ambulatory Medical Care Survey Outpatient Department (NHAMCS-OPD) or Emergency Department (NHAMCS-ED) in the United States. The outcome of interest was visits for gout diagnosis and visits where a gout medication was prescribed. Read More

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http://dx.doi.org/10.1186/s41927-018-0020-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6390619PMC

Rapid and automatic discrimination between facial expressions in the human brain.

Neuropsychologia 2019 Mar 15. Epub 2019 Mar 15.

Developmental Ethology and Cognitive Psychology Group, Centre des Sciences du Goût et de l'Alimentation, CNRS, Université Bourgogne Franche-Comté, Inra, AgroSup Dijon, F-21000, Dijon, France. Electronic address:

Automatic responses to brief expression changes from a neutral face have been recently isolated in the human brain using fast periodic visual stimulation (FPVS) coupled with scalp electroencephalography (EEG). Based on these observations, here we isolate specific neural signatures for the rapid categorization of each of 5 basic expressions, i.e. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00283932193006
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http://dx.doi.org/10.1016/j.neuropsychologia.2019.03.006DOI Listing
March 2019
1 Read

Early influencing factors on the development of sensory and food preferences.

Curr Opin Clin Nutr Metab Care 2019 Mar 14. Epub 2019 Mar 14.

Centre des Sciences du GoÛt et de l'Alimentation, AgroSup Dijon, CNRS, INRA, Université Bourgogne Franche-Comté, Dijon, France.

Purpose Of Review: The current review focuses on studies investigating the factors related to the development of preferences for foods and sensory inputs (tastes, odours, and food textures) in the first years of life, which constitutes a specific window for food learning.

Recent Findings: Foetal nutrition, intrauterine growth, and prematurity influence food preferences; this topic warrants more research to broaden our understanding of the 1000 days phenomenon. Although it is less studied than other sensory inputs, food texture acceptance, and the related sensitive period for texture introduction are attracting more attention, as is the impact of fat acceptance. Read More

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http://dx.doi.org/10.1097/MCO.0000000000000554DOI Listing

Imaging in rheumatoid arthritis: the role of magnetic resonance imaging and computed tomography.

Radiol Med 2019 Mar 18. Epub 2019 Mar 18.

Department of Radiology, Bispebjerg and Frederiksberg Hospital, University of Copenhagen, Copenhagen, Denmark.

In suspected and diagnosed rheumatoid arthritis (RA), magnetic resonance imaging (MRI) allows detection of all relevant pathologies, such as synovitis, tenosynovitis, bone marrow edema (osteitis), bone erosion and cartilage damage. MRI is more sensitive than clinical examination for monitoring disease activity (i.e. Read More

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http://link.springer.com/10.1007/s11547-019-01014-y
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http://dx.doi.org/10.1007/s11547-019-01014-yDOI Listing
March 2019
1 Read

Death of captive-bred vultures caused by flunixin poisoning in Italy.

Environ Toxicol Pharmacol 2019 Mar 11;68:91-93. Epub 2019 Mar 11.

Istituto Zooprofilattico Sperimentale del Lazio e della Toscana "M. Aleandri", Via Appia Nuova 1411, 00178 Rome, Italy. Electronic address:

Among non steroidal anti-inflammatory drugs (NSAIDs) diclofenac is considered the main cause for the decline of vulture populations in the Indian subcontinent since the '90 s. Chemical analysis showed high levels of flunixin (31,350 μg/kg) in beef which three captive Gyps vultures fed on, later dying with severe visceral gout. Levels in dead vultures' organs and tissues ranged from 4 to 38. Read More

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http://dx.doi.org/10.1016/j.etap.2019.03.011DOI Listing

Gout is associated with a higher risk of chronic renal disease in older adults: a retrospective cohort study of U.S. Medicare population.

BMC Nephrol 2019 Mar 15;20(1):93. Epub 2019 Mar 15.

Department of Medicine at School of Medicine, University of Alabama at Birmingham, 1720 Second Ave. South, Birmingham, AL, 35294-0022, USA.

Background: Hyperuricemia and gout have been linked to chronic kidney disease (CKD). Whether the increased risk of CKD in gout is due to shared risk factors such as hypertension, diabetes or heart disease, or due to gout itself is not known. Studies in older adults, who tend to have a high incidence of CKD, are limited. Read More

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http://dx.doi.org/10.1186/s12882-019-1274-5DOI Listing

Use of Pre-Infusion Serum Uric Acid Levels as a Biomarker for Infusion Reaction Risk in Patients on Pegloticase.

Rheumatol Ther 2019 Mar 14. Epub 2019 Mar 14.

Horizon Pharma, Lake Forest, IL, USA.

Introduction: The aim of this work is to evaluate the impact of the timing of pre-infusion serum uric acid (sUA) test results for use in applying stopping rules for pegloticase to identify patients at risk for infusion reactions (IRs) while on therapy.

Methods: Data from the phase 3 clinical trials of pegloticase were reviewed and individual uric acid levels of the 85 patients who received the approved regimen of biweekly infusions were examined in relation to the occurrence of IRs.

Results: Of the 22 patients (26%) who experienced an IR on pegloticase therapy without uric acid stopping rules, only seven (8%) would have had IRs if pegloticase therapy had been discontinued after two consecutive pre-infusion sUA levels above 6 mg/dl. Read More

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http://dx.doi.org/10.1007/s40744-019-0151-9DOI Listing

Dual actions on gout flare and acute kidney injury along with enhanced renal transporter activities by Yokuininto, a Kampo medicine.

BMC Complement Altern Med 2019 Mar 12;19(1):57. Epub 2019 Mar 12.

The K-herb Research Center, Korea Institute of Oriental Medicine, 1672 Yuseong-daero, Yuseong-gu, Daejeon, 34054, Republic of Korea.

Background: Prolonged hyperuricemia is associated with kidney disease or gouty arthritis. Whether Yokuininto, a commercially available Kampo medicine that has been used for osteoarthritis or rheumatoid arthritis, can exhibit anti-hyperuricemic and inflammatory effects remains elusive. In the present study, Yokuininto exerts multiple homeostatic action on serum uric acid (sUA) levels by blocking pro-inflammatory cytokine activities and inducing uricosuric function with anti-renal injury functions. Read More

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http://dx.doi.org/10.1186/s12906-019-2469-9DOI Listing
March 2019
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Ultra-performance hydrophilic interaction liquid chromatography coupled with tandem mass spectrometry for simultaneous determination of allopurinol, oxypurinol and lesinurad in rat plasma: Application to pharmacokinetic study in rats.

PLoS One 2019 14;14(3):e0213786. Epub 2019 Mar 14.

Medicinal Chemistry and Molecular Modelling Lab, Department of Pharmaceutical Chemistry, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi, India.

A fixed dose combination of lesinurad and allopurinol has been recently approved by USFDA and EMA for treatment of gout-associated hyperuricemia in patients who have not achieved target serum uric acid levels with allopurinol alone. In this study, an ultra-performance hydrophilic interaction liquid chromatography (UPHILIC) coupled with tandem mass spectrometry method was developed and validated for simultaneous determination of allopurinol, oxypurinol and lesinurad in rat plasma. Liquid liquid extraction using ethyl acetate as extracting agent was used for samples extraction procedure. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0213786PLOS
March 2019
3 Reads

Patient-Centered Outcomes and Key Study Procedure Finalization in the Pilot Feasibility Gout Randomized Trial: Comparative Feasibility Study in GOUt, CHerry Extract Versus Diet Modification (Mini-GOUCH).

J Clin Rheumatol 2019 Mar 12. Epub 2019 Mar 12.

Division of Infectious Diseases, Department of Medicine at School of Medicine, and.

Objective: The aim of this study was to report patient-centered outcomes and finalization of key study procedures from a 9-month pilot internet randomized controlled trial of cherry extract versus diet modification.

Methods: We randomized 84 people with physician-confirmed gout in an internet study to cherry extract (n = 41) or dietitian-assisted diet modification for gout (n = 43). All study outcomes were collected via internet and phone calls. Read More

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http://dx.doi.org/10.1097/RHU.0000000000001018DOI Listing
March 2019
2 Reads

[Gout with tophi].

Rev Prat 2018 Nov;68(9):987

Service de médecine interne, Hôpital américain de Paris, Neuilly-sur-Seine, France.

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November 2018
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Association Of Non-Alcoholic Fatty Liver Disease With Serum Uric Acid.

J Ayub Med Coll Abbottabad 2019 Jan-Mar;31(1):64-66

Department of Surgery, Ayub Medical College Abbottabad, Pakistan.

Background: Non-alcoholic fatty liver disorder is a clinicopathological condition, characterized by macro vesicular steatosis in hepatic cells and metabolic stress related disorders without other causes of chronic hepatic disease. Uric acid is basically a heterocyclic compound of hydrogen, carbon, oxygen and nitrogen. Uric acid is the metabolic end product of purine metabolism. Read More

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March 2019
2 Reads

Cardiovascular Disease in Gout and the Protective Effect of Treatments Including Urate-Lowering Therapy.

Drugs 2019 Mar 13. Epub 2019 Mar 13.

Department of Medicine, University of Alabama School of Medicine, 510 20th Street South, Faculty Office Tower 805B, Birmingham, AL, 35294, USA.

Cardiovascular disease affects more than 90 million Americans. Recent studies support an increased cardiovascular disease risk in inflammatory conditions, such as gout. Increased serum urate levels, or hyperuricemia, are a precursor to gout. Read More

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http://dx.doi.org/10.1007/s40265-019-01081-5DOI Listing
March 2019
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Metal-Assisted and Microwave-Accelerated Decrystallization of Pseudo-Tophus in Synthetic Human Joint Models.

ACS Omega 2019 Feb;4(2):4417-4428

Department of Civil Engineering, Department of Physics and Engineering Physics, and Department of Biology, Morgan State University, 1700 East Cold Spring Lane, Baltimore, Maryland 21251, United States.

In this paper, we tested a hypothesis that the metal-assisted and microwave-accelerated decrystallization (MAMAD) technique, based on the combined use of low-power medical microwave heating (MWH) and gold nanoparticles (Au NPs), can be used to decrystallize laboratory-prepared monosodium urate monohydrate crystal aggregate (pseudo-tophus) placed in three-dimensional (3D) synthetic human joint models. To simulate a potential treatment of chronic tophaceous gout using the MAMAD technique, we used three different 3D synthetic human joint models and assessed the percent mass reduction (PMR, i.e. Read More

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http://dx.doi.org/10.1021/acsomega.8b03497DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6407899PMC
February 2019
1 Read

Safety and Efficacy of Bempedoic Acid to Reduce LDL Cholesterol.

N Engl J Med 2019 03;380(11):1022-1032

From the Imperial Centre for Cardiovascular Disease Prevention, Department of Primary Care and Public Health, Imperial College London, London (K.K.R.); the Louisville Metabolic and Atherosclerosis Research Center, Louisville, KY (H.E.B.); the University of Milan and Multimedica IRCCS, Milan (A.L.C.); Esperion Therapeutics, Ann Arbor, MI (N.D.L., L.T.B., L.R.S., P.L.R.); and Baylor College of Medicine, Houston (C.M.B.).

Background: Short-term studies have shown that bempedoic acid, an inhibitor of ATP citrate lyase, reduces levels of low-density lipoprotein (LDL) cholesterol. Data are limited regarding the safety and efficacy of bempedoic acid treatment in long-term studies involving patients with hypercholesterolemia who are receiving guideline-recommended statin therapy.

Methods: We conducted a randomized, controlled trial involving patients with atherosclerotic cardiovascular disease, heterozygous familial hypercholesterolemia, or both. Read More

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http://dx.doi.org/10.1056/NEJMoa1803917DOI Listing
March 2019
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Precision drug repurposing via convergent eQTL-based molecules and pathway targeting independent disease-associated polymorphisms.

Pac Symp Biocomput 2019 ;24:308-319

Center for Biomedical Informatics and Biostatistics (CB2), The University of Arizona, Tucson, AZ 85721, USA2Department of Medicine COM-T, The University of Arizona, Tucson, AZ 85721, USA†Authors contributed equally to this work,

Repurposing existing drugs for new therapeutic indications can improve success rates and streamline development. Use of large-scale biomedical data repositories, including eQTL regulatory relationships and genome-wide disease risk associations, offers opportunities to propose novel indications for drugs targeting common or convergent molecular candidates associated to two or more diseases. This proposed novel computational approach scales across 262 complex diseases, building a multi-partite hierarchical network integrating (i) GWAS-derived SNP-to-disease associations, (ii) eQTL-derived SNP-to-eGene associations incorporating both cis- and trans-relationships from 19 tissues, (iii) protein target-to-drug, and (iv) drug-to-disease indications with (iv) Gene Ontology-based information theoretic semantic (ITS) similarity calculated between protein target functions. Read More

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January 2019
2 Reads

Febuxostat and Cardiovascular Events: A Systematic Review and Meta-Analysis.

Int J Rheumatol 2019 3;2019:1076189. Epub 2019 Feb 3.

Division of Population Health and Computational Medicine, Miller School of Medicine, University of Miami, Miami, FL, USA.

Background: Febuxostat is approved in the United States for the management of hyperuricemia in patients with gout. In November 2017 the FDA released a warning alert on a possible link between febuxostat and cardiovascular disease (CVD) reported in a single clinical trial.

Objective: To conduct a systematic review and meta-analysis and assess the risk of major adverse cardiovascular events (MACE) in patients receiving febuxostat compared to a control group. Read More

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http://dx.doi.org/10.1155/2019/1076189DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6378016PMC
February 2019
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IL-33 Ameliorates the Development of MSU-Induced Inflammation Through Expanding MDSCs-Like Cells.

Front Endocrinol (Lausanne) 2019 26;10:36. Epub 2019 Feb 26.

Department of Rheumatology and Clinical Immunology, Jiangxi Provincial People's Hospital, Nanchang, China.

Interleukin-33 (IL-33), a member of the IL-1 superfamily, has been shown to play a critical role in many diseases through regulating the immune cell responses, including myeloid-derived suppressor cells (MDSCs). Our previous study demonstrated that IL-33 might play a protective role in kidney injury in gout patients by regulating the lipid metabolism. However, the role of IL-33in the development of MSU-induced inflammation remains elusive. Read More

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http://dx.doi.org/10.3389/fendo.2019.00036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6399133PMC
February 2019
2 Reads

In Vitro Anti-proliferative Activity and Mechanism of Action of .

Int J Mol Sci 2019 Mar 11;20(5). Epub 2019 Mar 11.

Department of Biochemistry and Microbiology, PO Box 77000, Nelson Mandela University, Port Elizabeth 6031, South Africa.

is part of the Ranunculaceae genus (order Ranunculales) which comprises more than 150 species. Various parts of the plant have been used for the treatment of numerous medical conditions such as headaches, tertian agues, rheumatic gout, leprosy, lethargy, eye inflammation as well as malignant and corroding ulcers. The plants have been found to contain various medicinal compounds with anti-cancer, immunomodulatory, anti-inflammatory, anti-oxidant and anti-microbial activities. Read More

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http://dx.doi.org/10.3390/ijms20051217DOI Listing
March 2019
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Factors Associated with Functional Disability Among Lebanese Elderly Living in Rural Areas: Role of Polypharmacy, Alcohol Consumption, and Nutrition-based on the Aging and Malnutrition in Elderly Lebanese (AMEL) Study.

J Epidemiol Glob Health 2018 Dec;8(1-2):82-90

Faculty of Pharmacy, Lebanese University, Beirut, Lebanon.

The objective is to describe disability risk factors in Lebanese elderly living in rural settings, focusing on the role of polypharmacy, alcohol consumption, and nutrition. The Aging and Malnutrition in Elderly Lebanese study, a cross-sectional population-based one (April 2011-April 2012), included 1200 individuals aged ≥65 years from 24 Lebanese rural districts. The results showed that 288 (24%) were disabled and 287 (23. Read More

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http://dx.doi.org/10.2991/j.jegh.2018.08.002DOI Listing
December 2018
1 Read

Development and validation of a patient-reported gout attack intensity score for use in gout clinical studies.

Rheumatology (Oxford) 2019 Mar 11. Epub 2019 Mar 11.

Arthritis Center Twente, Department of Psychology, Health and Technology, University of Twente.

Objective: Inflammation-related symptoms such as pain, swelling and tenderness of the affected joint are frequently assessed using 5-point diary rating scales in gout clinical trials. Combining these into a single gout attack symptom intensity score may be a useful summary measure for these data, which is potentially more responsive to change compared with the individual components. The objective of this study was to develop a patient-reported gout flare intensity score, the Gout Attack Intensity Score (GAIS), for use in clinical studies, that includes components for gout-related pain, swelling and tenderness. Read More

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http://dx.doi.org/10.1093/rheumatology/kez064DOI Listing

Weanling Infants Prefer the Odors of Green Vegetables, Cheese, and Fish When Their Mothers Consumed These Foods During Pregnancy and/or Lactation.

Chem Senses 2019 Feb 19. Epub 2019 Feb 19.

Centre des Sciences du Goût et de l'Alimentation, AgroSup Dijon, CNRS, INRA, Université Bourgogne Franche-Comté, Dijon, France.

Infants' olfactory experience begins before birth and extends after birth through milk and complementary foods. Until now, studies on the effects of chemosensory experience in utero and/or through human milk focused on experimentally controlled exposure to only 1 target food bearing a specific odor quality and administered in sizeable amounts. This study aimed to assess whether early olfactory experience effect was measurable in "everyday conditions" of maternal food intake during pregnancy and lactation, and of infant intake at weaning, leading to expose the infant to corresponding odors as fetus, neonate, and infant up to 8 and 12 months of age. Read More

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http://dx.doi.org/10.1093/chemse/bjz011DOI Listing
February 2019
1 Read

Tonic spinal cord stimulation as therapeutic option in Parkinson disease with axial symptoms: Effects on walking and quality of life.

Parkinsonism Relat Disord 2019 Mar 2. Epub 2019 Mar 2.

James Parkinson Unit, Department of Neurology, Fondation Ophtalmologique Adolphe de Rothschild, Paris, France.

Spinal cord stimulation (SCS) is an effective surgical therapy used for the treatment of chronic neuropathic pain. Tonic SCS is safe and improve not only gait disorders, motor symptoms, but also quality of life in Parkinson patients even with dopa-resistant symptoms with or without associated deep brain stimulation. Read More

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http://dx.doi.org/10.1016/j.parkreldis.2019.02.044DOI Listing
March 2019
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The anti-hyperuricemic effect of four astilbin stereoisomers in Smilax glabra on hyperuricemic mice.

J Ethnopharmacol 2019 Mar 6. Epub 2019 Mar 6.

Key Laboratory of Modern Preparation of Traditional Chinese Medicine, Jiangxi University of Traditional Chinese Medicine, Ministry of Education, Nanchang, 330004, China. Electronic address:

Ethnopharmacological Relevance: Smilax glabra Roxb. (SG), a Chinese medicinal herb which called "tufuling", is believed to be effective in treating hyperuricemia and gout symptoms. But the active substance and pharmacological mechanism of reducing uric acid remain unknown. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03788741183414
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http://dx.doi.org/10.1016/j.jep.2019.03.004DOI Listing
March 2019
2 Reads

Determination of Elements in Gymnema inodorum Lour by Particle Induced X-Ray Emission (PIXE).

Biol Trace Elem Res 2019 Mar 7. Epub 2019 Mar 7.

Plasma and Beam Physics Research Facility, Faculty of Science, Chiang Mai University, Chiang Mai, 50200, Thailand.

At present, Thailand uses medicinal plants to treat various diseases. Alternative medicine utilizes Gymnema inodorum Lour for antipyretic and anti-allergic purposes. There are also other research studies to treat diabetes mellitus, coronary artery disease, cataract, rheumatoid arthritis, gout, liver cancer, and stomach cancer. Read More

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http://link.springer.com/10.1007/s12011-019-01669-8
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http://dx.doi.org/10.1007/s12011-019-01669-8DOI Listing
March 2019
3 Reads

Comparison table: Some drugs for gout.

Authors:

Med Lett Drugs Ther 2019 Mar 11;61(1567):e40-e42. Epub 2019 Mar 11.

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March 2019
1 Read

Drugs for gout.

Authors:

Med Lett Drugs Ther 2019 Mar;61(1567):33-37

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March 2019
1 Read

Characterization of patients with chronic refractory gout who do and do not have clinically apparent tophi and their response to pegloticase.

Rheumatology (Oxford) 2019 Mar 6. Epub 2019 Mar 6.

AMPEL BioSolutions, LLC, Charlottesville, VA, USA.

Objectives: To determine the characteristics and response to pegloticase of patients with chronic refractory gout with and without clinically apparent tophi.

Methods: Results from two randomized controlled trials of pegloticase in patients with chronic refractory gout with clinically apparent tophi or without tophi were used to assess baseline and on-treatment between-group differences.

Results: Patients with tophi were significantly older than those without tophi, had a significantly longer duration of disease, higher numbers of tender and swollen joints, higher Patient Global Assessment scores and Health Assessment Questionnaire-Disability Index scores, and lower Arthritis-Specific Health Index scores. Read More

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http://dx.doi.org/10.1093/rheumatology/kez017DOI Listing
March 2019
1 Read

Elevated expression of interleukin-37 in patients with rheumatoid arthritis.

Int J Rheum Dis 2019 Mar 6. Epub 2019 Mar 6.

Department of Evidence-Based Medicine, School of Public Health, Southwest Medical University, Luzhou, Sichuan, China.

Aim: This study aims to discuss plasma and messenger RNA (mRNA) levels of interleukin (IL)-37 in rheumatoid arthritis (RA) patients and evaluate the potential of plasma IL-37 as a biomarker for RA.

Method: Plasma IL-37 levels and IL-37 mRNA relative concentrations were measured by enzyme-linked immunosorbent assay (ELISA) and quantitative reverse transcriptase-polymerase chain reaction (RT-PCR). We discussed the association of IL-37 levels and clinical, laboratory parameters in RA patients in a training cohort. Read More

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http://dx.doi.org/10.1111/1756-185X.13539DOI Listing
March 2019
1 Read

Osteoclasts in the Inflammatory Arthritis: Implications for Pathologic Osteolysis.

Immune Netw 2019 Feb 20;19(1):e2. Epub 2019 Feb 20.

Division of Rheumatology, Department of Internal medicine, Kyungpook National University Hospital, Daegu, Korea.

The enhanced differentiation and activation of osteoclasts (OCs) in the inflammatory arthritis such as rheumatoid arthritis (RA) and gout causes not only local bone erosion, but also systemic osteoporosis, leading to functional disabilities and morbidity. The induction and amplification of NFATc1, a master regulator of OC differentiation, is mainly regulated by receptor activator of NF-κB (RANK) ligand-RANK and calcium signaling which are amplified in the inflammatory milieu, as well as by inflammatory cytokines such as TNFα, IL-1β and IL-6. Moreover, the predominance of CD4 T cell subsets, which varies depending on the condition of inflammatory diseases, can determine the fate of OC differentiation. Read More

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http://dx.doi.org/10.4110/in.2019.19.e2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6399096PMC
February 2019
1 Read

Revisiting the Association Between Systemic Lupus Erythematosus and Gout.

Reumatol Clin 2019 Mar 2. Epub 2019 Mar 2.

Department of Rheumatology, University Hospital of Strasbourg, France; Centre National de Référence "Maladies auto-immunes systémiques rares", France.

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http://dx.doi.org/10.1016/j.reuma.2019.01.001DOI Listing
March 2019
1 Read

Hyperuricemia is Associated with Immunoglobulin G N-Glycosylation: A Community-Based Study of Glycan Biomarkers.

OMICS 2019 Mar 5. Epub 2019 Mar 5.

3 Beijing Key Laboratory of Clinical Epidemiology, School of Public Health, Capital Medical University, Beijing, China.

The increasing prevalence of hyperuricemia has been recognized as an emerging public health concern in both developed and developing countries. Hyperuricemia is a metabolic condition characterized by an elevated serum uric acid, and associated with renal damage, diabetes, autoimmune disorders, and cardiovascular diseases. Although human genetic variation has been recognized as a factor, posttranslational cellular processes and glycan biomarkers have not been studied extensively for susceptibility to hyperuricemia. Read More

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http://dx.doi.org/10.1089/omi.2019.0004DOI Listing
March 2019
1 Read
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Modified Chuanhu anti-gout mixture, a traditional Chinese medicine, protects against potassium oxonate-induced hyperuricemia and renal dysfunction in mice.

J Int Med Res 2019 Mar 5:300060519831182. Epub 2019 Mar 5.

1 Department of Endocrinology, Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.

Objective: Acute gout is a painful, inflammatory arthritis that features a rapidly escalating inflammatory response resulting from the formation of monosodium urate crystals in the affected joint space. Previously, we found that Chuanhu anti-gout mixture (CAGM) had similar effects as colchicine against gout in the clinic. Subsequently, to improve its effectiveness and efficacy, we modified the original formulation of CAGM. Read More

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http://dx.doi.org/10.1177/0300060519831182DOI Listing
March 2019
2 Reads

Understanding the structure-function relationship of HPRT1 missense mutations in association with Lesch-Nyhan disease and HPRT1-related gout by in silico mutational analysis.

Comput Biol Med 2019 Feb 23;107:161-171. Epub 2019 Feb 23.

Department of Biomedical Sciences, College of Health and Sciences, Qatar University, Doha, Qatar. Electronic address:

The nucleotide salvage pathway is used to recycle degraded nucleotides (purines and pyrimidines); one of the enzymes that helps to recycle purines is hypoxanthine guanine phosphoribosyl transferase 1 (HGPRT1). Therefore, defects in this enzyme lead to the accumulation of DNA and nucleotide lesions and hence replication errors and genetic disorders. Missense mutations in hypoxanthine phosphoribosyl transferase 1 (HPRT1) are associated with deficiencies such as Lesch-Nyhan disease and chronic gout, which have manifestations such as arthritis, neurodegeneration, and cognitive disorders. Read More

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http://dx.doi.org/10.1016/j.compbiomed.2019.02.014DOI Listing
February 2019
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1.240 Impact Factor

Letter by Kuwabara Regarding Article, "Assessment of Cardiovascular Risk in Older Patients With Gout Initiating Febuxostat Versus Allopurinol: Population-Based Cohort Study".

Circulation 2019 Mar;139(10):1348-1349

Intensive Care Unit and Department of Cardiology, Toranomon Hospital, Tokyo, Japan.

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http://dx.doi.org/10.1161/CIRCULATIONAHA.118.037976DOI Listing
March 2019
3 Reads

The application of dual-energy computed tomography in the diagnosis of musculoskeletal disorders: a review of current concepts and applications.

Radiol Med 2019 Mar 4. Epub 2019 Mar 4.

Radiology Department, Università Politecnica delle Marche, Via Conca 71, 60020, Ancona, Italy.

With the assistance of innovations in scanner engineering and software design, dual-energy computed tomography (DECT) is an advanced imaging method that has been developed over the last decade. With its unique ability to differentiate materials by their atomic number, DECT has opened new perspectives in imaging. The principal advantages of DECT over conventional CT in the musculoskeletal setting relate to the additional information provided regarding tissue composition, artifact reduction and image optimization. Read More

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http://dx.doi.org/10.1007/s11547-019-01015-xDOI Listing
March 2019
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Moving the Needle: Improving the Care of the Gout Patient.

Rheumatol Ther 2019 Mar 2. Epub 2019 Mar 2.

Duke Gout and Crystal Arthropathies Clinic, Durham, NC, USA.

Gout is a the most common inflammatory arthritis in the United States. It is a significant cause of morbidity, disability, lost work days, and high healthcare utilization due to intermittent attacks, chronic inflammation, and joint damage. Despite our understanding of the prelude and pathophysiology of gout, hyperuricemia, it is still poorly misunderstood by patients and poorly managed by healthcare providers. Read More

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http://dx.doi.org/10.1007/s40744-019-0147-5DOI Listing
March 2019
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Precipitation of Soluble Uric Acid is Necessary for in vitro Activation of the NLRP3 Inflammasome in Primary Human Monocytes.

J Rheumatol 2019 Mar 1. Epub 2019 Mar 1.

Department and institution: Brighton and Sussex Medical School, University of Sussex, Brighton, UK, BN1 9PS Source of support: This work was supported by Brighton and Sussex Medical School. Corresponding author: Dr Lisa M Mullen. Medical Research Building, University of Sussex, Brighton, BN1 9PS.

Objective: To investigate the effects of soluble uric acid (UA) on expression and activation of the NODlike receptor (NLR) pyrin domain containing protein 3 (NLRP3) inflammasome in human monocytes to elucidate the role of hyperuricemia in the pathogenesis of gout.

Methods: Primary human monocytes and the THP-1 human monocyte cell line were used to determine the effects of short- and long-term exposure to UA on activation of the NLRP3 inflammasome and subsequent interleukin-1β (IL-1β) secretion by enzyme linked immunosorbent assay (ELISA) and cell-based assays. Expression of key NLRP3 components in monocytes from patients with a history of gout were analysed by quantitative PCR. Read More

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http://dx.doi.org/10.3899/jrheum.180855DOI Listing
March 2019
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Gout Presenting as Acute Hip Pain in a Young Woman: A Case Report.

JBJS Case Connect 2019 Feb 28. Epub 2019 Feb 28.

University of Kansas Medical Center, Kansas City, Kansas.

Case: A 28-year-old previously healthy woman developed worsening right hip pain without any preceding trauma or injury. Because of concern for septic arthritis, she underwent arthroscopic irrigation and debridement. The culture specimens were negative; crystal analysis showed monosodium urate crystals, which are consistent with an acute gout flare. Read More

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http://dx.doi.org/10.2106/JBJS.CC.18.00164DOI Listing
February 2019
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Robotic radical prostatectomy in 93 cases: Outcomes of the first ERUS robotic urology curriculum trained surgeon in Turkey.

Turk J Urol 2019 Feb 4. Epub 2019 Feb 4.

Clinic of Urology, Ankara Atatürk Training and Research Hospital, Ankara, Turkey.

Objective: This study presents the surgical, oncological, and functional outcomes of the first 93 robotic radical prostatectomy (RARP) procedures performed in Erzurum, Turkey. These procedures were performed by a single surgeon who had completed the European Association of Urology Robotic Urology Section (ERUS) RARP curriculum in an ERUS-certified training center in Ankara.

Material And Methods: The mean patient age was 63. Read More

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http://turkishjournalofurology.com/eng/makale/3461/155/Full-
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http://dx.doi.org/10.5152/tud.2019.24444DOI Listing
February 2019
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Nasal mucus glutathione transferase activity and impact on olfactory perception and neonatal behavior.

Sci Rep 2019 Feb 28;9(1):3104. Epub 2019 Feb 28.

Centre des Sciences du Goût et de l'Alimentation, UMR 6265 CNRS/1324 INRA/Université de Bourgogne Franche-Comté, 9 boulevard Jeanne d'Arc, F-21000, Dijon, France.

In olfaction, to preserve the sensitivity of the response, the bioavailability of odor molecules is under the control of odorant-metabolizing enzymes (OMEs) expressed in the olfactory neuroepithelium. Although this enzymatic regulation has been shown to be involved in olfactory receptor activation and perceptual responses, it remains widely underestimated in vertebrates. In particular, the possible activity of OMEs in the nasal mucus, i. Read More

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http://dx.doi.org/10.1038/s41598-019-39495-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6395716PMC
February 2019

Hyperuricemia and acute gout after laparoscopic sleeve gastrectomy.

Clin Obes 2019 Apr 27;9(2):e12296. Epub 2019 Feb 27.

Department of Surgery, University Hospital of Larissa, University of Thessaly, Larissa, Greece.

The aim of this study was to evaluate the prevalence of hyperuricemia and acute gout after laparoscopic sleeve gastrectomy (LSG). Risk factors for developing gout were also examined. Eighty-five patients underwent LSG were enrolled in this prospective study. Read More

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http://dx.doi.org/10.1111/cob.12296DOI Listing
April 2019
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mTOR inhibition by metformin impacts monosodium urate crystal-induced inflammation and cell death in gout: a prelude to a new add-on therapy?

Ann Rheum Dis 2019 Feb 27. Epub 2019 Feb 27.

Department of Rheumatology and Clinical Immunology, Laboratory of Translational Immunology, University Medical Center Utrecht, Utrecht, The Netherlands.

Objective: Gout is the most common inflammatory arthritis worldwide, and patients experience a heavy burden of cardiovascular and metabolic diseases. The inflammation is caused by the deposition of monosodium urate (MSU) crystals in tissues, especially in the joints, triggering immune cells to mount an inflammatory reaction. Recently, it was shown that MSU crystals can induce mechanistic target of rapamycin (mTOR) signalling in monocytes encountering these crystals in vitro. Read More

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http://dx.doi.org/10.1136/annrheumdis-2018-214656DOI Listing
February 2019
1 Read
10.377 Impact Factor