17,359 results match your criteria Gout


Effects of febuxostat on serum cytokines IL-1, IL-4, IL-6, IL-8, TNF-α and COX-2.

Exp Ther Med 2019 Jan 15;17(1):812-816. Epub 2018 Nov 15.

Department of Endocrinology Ⅱ, Affiliated Zhongshan Hospital of Dalian University, Dalian, Liaoning 116001, P.R. China.

Effects of febuxostat on serum cytokines interleukin (IL)-1, IL-4, IL-6, IL-8, tumor necrosis factor-α (TNF-α) and cyclooxygenase-2 (COX-2) in patients with gout were investigated. A total of 80 patients with gout admitted and treated in the Affiliated Zhongshan Hospital of Dalian University from January 2015 to September 2017 were selected and divided into two groups by virtue of a random number table, with 40 patients in each group. All the enrolled patients received strict gout diet adjustment and took colchicine at the same time. Read More

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http://dx.doi.org/10.3892/etm.2018.6972DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307400PMC
January 2019

The long and winding road in pharmaceutical development of canakinumab from rare genetic autoinflammatory syndromes to myocardial infarction and cancer.

Authors:
Hermann Gram

Pharmacol Res 2019 Jan 12. Epub 2019 Jan 12.

Novartis Institutes for BioMedical Research, Forum 1, CH-4002 Basel, Switzerland. Electronic address:

Interleukin-1beta (IL-1β) is an ancient and evolutionary conserved cytokine, which orchestrates innate immune responses triggered by infections in vertebrates. While temporally limited induction of IL-1β protects the organism against traumatic or infectious insults, its chronic production in unabated inflammation causes or enhances clinical manifestations of disease in almost all organ systems. Therefore, pharmacological targeting of IL-1β in a variety of clinical inflammatory conditions may provide symptomatic relief or profound disease modification. Read More

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http://dx.doi.org/10.1016/j.phrs.2019.01.023DOI Listing
January 2019

Use of Anakinra in Hospitalized Patients with Crystal-associated Arthritis.

J Rheumatol 2019 Jan 15. Epub 2019 Jan 15.

From the Division of Rheumatology, Department of Medicine, University of Washington, Seattle, Washington. Address correspondence to Jean W. Liew, MD, University of Washington, 1959 NE Pacific St, BB561, Seattle, WA 98195. Email:

Objective: In this retrospective observational study, we assess the efficacy and safety of the interleukin-1 receptor antagonist anakinra in medically complex, hospitalized patients with acute gout and calcium pyrophosphate crystal arthritis.

Methods: Adult inpatients patients treated with anakinra from 2014-2017 were identified for inclusion. Charts were reviewed for demographics, comorbidities, laboratory data, pain scores, joint involvement, prior treatment, dosing and response to anakinra, concurrent infections, and surgical interventions. Read More

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http://dx.doi.org/10.3899/jrheum.181018DOI Listing
January 2019

No causal effects of serum urate levels on the risk of chronic kidney disease: A Mendelian randomization study.

PLoS Med 2019 Jan 15;16(1):e1002725. Epub 2019 Jan 15.

Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America.

Background: Studies have shown strong positive associations between serum urate (SU) levels and chronic kidney disease (CKD) risk; however, whether the relation is causal remains uncertain. We evaluate whether genetic data are consistent with a causal impact of SU level on the risk of CKD and estimated glomerular filtration rate (eGFR).

Methods And Findings: We used Mendelian randomization (MR) methods to evaluate the presence of a causal effect. Read More

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http://dx.plos.org/10.1371/journal.pmed.1002725
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http://dx.doi.org/10.1371/journal.pmed.1002725DOI Listing
January 2019
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Ultrasound measurement of knee synovial fluid during external pneumatic compression.

J Orthop Res 2019 Jan 15. Epub 2019 Jan 15.

Department of Medicine Rheumatology Division National Jewish Health.

Synovial fluid based biomarker research has been limited by the small volumes of synovial fluid from the knees of some patients. We used ultrasound (US) to determine if synovial fluid could be displaced into an access port during pneumatic compression to 100 mmHg. Forty knees from thirty-seven consecutive arthritis patients with rheumatoid arthritis -25, osteoarthritis -8, psoriatic arthritis -2, and 1 each with systemic lupus erythematosus and gout were evaluated. Read More

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http://doi.wiley.com/10.1002/jor.24216
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http://dx.doi.org/10.1002/jor.24216DOI Listing
January 2019
1 Read

Evaluation of Turmeric Nanoparticles as Anti-Gout Agent: Modernization of a Traditional Drug.

Medicina (Kaunas) 2019 Jan 11;55(1). Epub 2019 Jan 11.

Department of Bioinformatics and Biotechnology, Faculty of Basic and Applied sciences, International Islamic University Islamabad, Islamabad, 44000, Pakistan.

Turmeric has assisted in the control of inflammation and pain for decades and has been used in combination with other nutraceuticals to treat acute and chronic osteoarthritis pain. Recently, the effect of turmeric, turmeric extract, or curcuminoids on musculoskeletal pain, either by themselves or in conjunction with other substances, has been reported. The aim of this study was to develop and characterize turmeric nanoparticles (T-NPs) for various parameters, both in vitro and in vivo. Read More

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http://dx.doi.org/10.3390/medicina55010010DOI Listing
January 2019
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Web Exclusive. Annals On Call - Understanding Gout Pathophysiology.

Ann Intern Med 2019 01;170(2):OC1

University of Alabama at Birmingham, Birmingham, Alabama (A.L.G.).

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http://dx.doi.org/10.7326/A18-0012DOI Listing
January 2019

Allopurinol-Induced Stevens-Johnson Syndrome.

Am J Med Sci 2018 Dec 4. Epub 2018 Dec 4.

Department of Critical Care Medicine, Maimonides Medical Center, Brooklyn, New York.

Allopurinol is a first line agent in treating gout, but it also carries the risk of severe side effects. Stevens-Johnson syndrome (SJS) is one of the life threatening severe cutaneous adverse reactions caused by allopurinol. The severity of the severe cutaneous adverse reactions can be categorized based upon the area of skin involvement: (1) erythema multiforme major limited to 1-2 % of the body surface area (BSA); (2) SJS involving <10% of the BSA, (3) SJS and toxic epidermal necrolysis overlap involving 10-30% of the BSA and (4) toxic epidermal necrolysis syndrome involving >30% of the BSA. Read More

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http://dx.doi.org/10.1016/j.amjms.2018.11.018DOI Listing
December 2018

Experience of finding footwear and factors contributing to footwear choice in people with gout: a mixed methods study using a web-based survey.

J Foot Ankle Res 2019 8;12. Epub 2019 Jan 8.

1Department of Podiatry, Health and Rehabilitation Research Institute, Auckland University of Technology, Private Bag 92006, Auckland, 1142 New Zealand.

Background: Gout frequently affects the foot, particularly the first metatarsophalangeal joint. People with gout commonly wear ill-fitting footwear that lacks cushioning and support, which may further contribute to foot pain and disability. Footwear with good cushioning and motion control may be an effective non-pharmacological intervention. Read More

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http://dx.doi.org/10.1186/s13047-018-0313-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6325840PMC
January 2019

A Pilot Study: Urinary Uromodulin-Creatinine Ratio as a Potential Clinical Biomarker for CKD Patients with Gout.

Med Princ Pract 2019 Jan 13. Epub 2019 Jan 13.

Objective: Recent studies have reported that reduced excretion of urinary uromodulin (uUMOD) was associated with renal tubular function and risks of progressive kidney disease. Gouty nephropathy is usually seen in patients with gout. Patients with chronic gouty nephropathy are characterized by the deposition of monosodium urate crystals primarily involving the collecting ducts in the medulla. Read More

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http://dx.doi.org/10.1159/000496844DOI Listing
January 2019

Cardiorespiratory Fitness and Risk of All-Cause, Cardiovascular Disease, and Cancer Mortality in Men With Musculoskeletal Conditions.

J Phys Act Health 2019 Jan 11:1-7. Epub 2019 Jan 11.

Background: To investigate the association between cardiorespiratory fitness and risk of cardiovascular disease, cancer, and all-cause mortality in men with musculoskeletal conditions.

Methods: Participants were 12,728 men (mean age 47.0 [9. Read More

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http://dx.doi.org/10.1123/jpah.2017-0644DOI Listing
January 2019

Gout as a Risk Factor for Dry Eye Disease: A Population-Based Cohort Study.

J Clin Med 2019 Jan 9;8(1). Epub 2019 Jan 9.

Institute of Medicine, Chung Shan Medical University, Taichung 402, Taiwan.

This study evaluated the effect of gout on the risk of dry eye disease (DED) by using the National Health Insurance Research Database (NHIRD). Data for 30,192 gout patients (21,081 men and 9111 women) and 30,192 non-gout patients (21,005 men and 9187 women) were analyzed. Approximately 1 million patients were randomly sampled from the NHIRD registry. Read More

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http://www.mdpi.com/2077-0383/8/1/62
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http://dx.doi.org/10.3390/jcm8010062DOI Listing
January 2019
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IL-1β functionally attenuates ABCG2 and PDZK1 expression in HK-2 cells partially through NF-κB activation.

Cell Biol Int 2019 Jan 11. Epub 2019 Jan 11.

Department of Rheumatology, the Second Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou, 310009, China.

Long-standing untreated hyperuricemia could lead to gout. Several recent studies have demonstrated a significant decrease of serum urate during acute gout attack, which is an aseptic inflammation process focusing on IL-1β. However, how IL-1β, by itself, alters the expression and the functional activity of urate transporters in renal tubular epithelial cells is still unclear. Read More

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http://doi.wiley.com/10.1002/cbin.11100
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http://dx.doi.org/10.1002/cbin.11100DOI Listing
January 2019
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Incidentally Detected Amyloid Light-Chain Amyloidosis Caused by Monoclonal Gammopathy of Undetermined Significance: Possible Time-Dependent Change in Colonic Findings.

Case Rep Gastroenterol 2018 Sep-Dec;12(3):737-746. Epub 2018 Dec 6.

Division of Gastroenterology and Hepatology, Third Department of Internal Medicine, Kansai Medical University, Hirakata, Hirakata, Japan.

Amyloid light-chain (AL) amyloidosis is associated with plasma cell disorder and monoclonal light chains. This type of amyloidosis is the prominent type involving the gastrointestinal tract. Monoclonal gammopathy of undetermined significance (MGUS) is the most common plasma cell disorder and a known precursor of more serious diseases. Read More

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http://dx.doi.org/10.1159/000494919DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323391PMC
December 2018

Discovery of 2-phenylthiazole-4-carboxylic acid, a novel and potent scaffold as xanthine oxidase inhibitors.

Bioorg Med Chem Lett 2019 Jan 7. Epub 2019 Jan 7.

School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, PR China; Key Laboratory of New Drug Discovery and Evaluation of Ordinary Universities of Guangdong Province, Guangdong Pharmaceutical University, Guangzhou 510006, PR China. Electronic address:

The xanthine oxidase (XO) plays an important role in producing uric acid, and therefore XO inhibitors are considered as one of the promising therapies for hyperuricemia and gout. We have previously reported a series of XO inhibitors with pyrazole scaffold to extend the chemical space of current XO inhibitors. Herein, we describe further structural optimization to explore the optimal heterocycle by replacing the thiazole ring of Febuxostat with 5 heterocycle scaffolds unexplored in this field. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0960894X193000
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http://dx.doi.org/10.1016/j.bmcl.2019.01.005DOI Listing
January 2019
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Achievement of Target Serum Uric Acid Levels and Factors Associated with Therapeutic Failure among Japanese Men Treated for Hyperuricemia/Gout.

Intern Med 2019 Jan 10. Epub 2019 Jan 10.

Department of General Medicine, Juntendo University School of Medicine, Japan.

Objective To assess the rate of successfully achieving treatment goals among Japanese men with hyperuricemia/gout and identify factors influencing the success rate. Methods This cross-sectional study, conducted from January to December 2012, examined the serum uric acid (SUA) levels and clinical characteristics of 2,103 men with hyperuricemia/gout selected from an initial population of 136,770 individuals who participated in a workplace health checkup. The success rates (defined as SUA ≤6. Read More

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https://www.jstage.jst.go.jp/article/internalmedicine/advpub
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http://dx.doi.org/10.2169/internalmedicine.1899-18DOI Listing
January 2019
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A rare cause of back pain and radiculopathy - spinal tophi: a case report.

J Med Case Rep 2019 Jan 8;13(1). Epub 2019 Jan 8.

Orthopaedics Department, Universiti Malaysia Sarawak, 94300, Kota Samarahan, Sarawak, Malaysia.

Background: Gout is a monosodium urate deposition disease which is prevalent worldwide. The usual manifestations are crystal arthropathy and tophi deposition in the soft tissues. Spinal tophi may also occur and are rarely reported, resulting in various clinical manifestations such as back pain, spinal cord compression, radiculopathy, and even mimicking epidural abscess and spondylodiscitis. Read More

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http://dx.doi.org/10.1186/s13256-018-1940-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6325858PMC
January 2019

Interactions between serum urate-associated genetic variants and sex on gout risk: analysis of the UK Biobank.

Arthritis Res Ther 2019 Jan 9;21(1):13. Epub 2019 Jan 9.

Department of Medicine, Faculty of Medical and Health Sciences, University of Auckland, 85 Park Road, Grafton, Auckland, 1023, New Zealand.

Background: Sex-specific differences in the effect of genetic variants on serum urate levels have been described. The aim of this study was to systematically examine whether serum urate-associated genetic variants differ in their influence on gout risk in men and women.

Methods: This research was conducted using the UK Biobank Resource. Read More

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https://arthritis-research.biomedcentral.com/articles/10.118
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http://dx.doi.org/10.1186/s13075-018-1787-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327586PMC
January 2019
2 Reads

Indicators of Male Gout Patients' Comorbidities with the Theory on Traditional Chinese Medicine.

Evid Based Complement Alternat Med 2018 4;2018:9679213. Epub 2018 Dec 4.

Graduate School of Peking Union Medical College, Beijing, China.

Gout, typically manifesting as acute burning pain and swelling in a joint, has a high frequency of comorbidities. Based on Traditional Chinese Medicine syndrome (TCMS) theory, obstruction of dampness and heat syndrome (ODHS) and intermingled phlegm-stasis blood syndrome (IPSBS) were the two main TCMS subtypes in Chinese suffering from acute gout. In this study, we did a retrospective study enrolling 4,417 ODHS male gout cases and 1,413 IPSBS male gout cases, to investigate the comorbidities distribution difference between the two subtype groups and seek the potential indicators of male gout with some comorbidities. Read More

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http://dx.doi.org/10.1155/2018/9679213DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304596PMC
December 2018

Ethanol Extract of Leaf Ameliorates Hyperuricemia in Mice via Inhibition of Hepatic and Serum Xanthine Oxidase Activity.

Evid Based Complement Alternat Med 2018 2;2018:8037925. Epub 2018 Dec 2.

Department of Pharmacy, College of Pharmacy, Mokpo National University, Muan, Jeonnam 58554, Republic of Korea.

Bureau (Moraceae) (CT) is a dietary and medicinal plant distributed widely in Northeast Asia. There have been no studies on the effect of CT and/or its active constituents on xanthine oxidase (XO) activity, hyperuricemia, and gout. The aim of this study was to investigate XO inhibitory and antihyperuricemic effects of the ethanol extract of CT leaf (CTLE) and its active constituents and . Read More

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https://www.hindawi.com/journals/ecam/2018/8037925/
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http://dx.doi.org/10.1155/2018/8037925DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304516PMC
December 2018
1 Read

Unusual presentation of gouty tophus in the liver with subsequent appearance in the same site of HCC: a correlate diagnosis? Case report.

World J Surg Oncol 2019 Jan 8;17(1):10. Epub 2019 Jan 8.

Department of Clinical and Experimental Sciences, Surgical Clinic, University of Brescia, Brescia, Italy.

Background: Although gout is a common disease, the presence of gouty tophi outside joints is rare and in literature, there is to date only one report of hepatic tophaceous nodule. We would like to highlight here the difficult diagnostic workup in a patient with history of cancer and the presence of a tophus inside the liver. Moreover, we address the possible etiologic role of chronic inflammation related to tophi and liver cancer. Read More

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http://dx.doi.org/10.1186/s12957-018-1546-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6325729PMC
January 2019
2 Reads

Polymorphisms of and Genes Associated with Gout Risk in Vietnamese Population.

Medicina (Kaunas) 2019 Jan 7;55(1). Epub 2019 Jan 7.

Institute of Genome Research, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Cau Giay, Hanoi 100000, Vietnam.

Gout is a common form of inflammatory arthritis caused by the crystallization of uric acid. Previous studies have demonstrated that the genetic predisposition of gout varies in different ethnic populations. However the association study of genetic variants with gout remains unknown in the Vietnamese population. Read More

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http://www.mdpi.com/1010-660X/55/1/8
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http://dx.doi.org/10.3390/medicina55010008DOI Listing
January 2019
1 Read

One year in review 2018: gout.

Clin Exp Rheumatol 2018 Dec 21. Epub 2018 Dec 21.

Rheumatology Unit, Department of Medicine - DIMED, University of Padova, ltaly.

Gout is the most common form of inflammatory arthropathy, and is associated with excruciating pain, major impairment of quality of life, and increased risk of comorbidities and mortality. Although gout has somehow been neglected by researchers and clinicians in the past, in more recent times there has been a renewed interest in this disease, which has led to major improvements in its management. This article reviews the new clinical and experimental evidence about gout that emerged in 2017 and in the first half of 2018. Read More

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December 2018
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Lack of Hypothalamus Polysialylation Inducibility Correlates With Maladaptive Eating Behaviors and Predisposition to Obesity.

Front Nutr 2018 10;5:125. Epub 2018 Dec 10.

Centre des Sciences du Goût et de l'Alimentation, AgroSup Dijon, CNRS, INRA, Université de Bourgogne, Dijon, France.

High variability exists in individual susceptibility to develop overweight in an obesogenic environment and the biological underpinnings of this heterogeneity are poorly understood. In this brief report, we show in mice that the vulnerability to diet-induced obesity is associated with low level of polysialic acid-neural cell adhesion molecule (PSA-NCAM), a factor of neural plasticity, in the hypothalamus. As we previously shown that reduction of hypothalamic PSA-NCAM is sufficient to alter energy homeostasis and promote fat storage under hypercaloric pressure, inter-individual variability in hypothalamic PSA-NCAM might account for the vulnerability to diet-induced obesity. Read More

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https://www.frontiersin.org/article/10.3389/fnut.2018.00125/
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http://dx.doi.org/10.3389/fnut.2018.00125DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6295648PMC
December 2018
2 Reads

Contemporary Prevalence of Gout and Hyperuricemia in the United States and Decadal Trends: The National Health and Nutrition Examination Survey 2007-2016.

Arthritis Rheumatol 2019 Jan 7. Epub 2019 Jan 7.

Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.

Objectives: To estimate the contemporary prevalences of gout and hyperuricemia and their decadal trends in the US, as well as the prevalence of urate-lowering therapy (ULT) use among gout patients, using data from the latest and prior nationally-representative samples of US men and women (National Health and Nutrition Examination Survey [NHANES] 2007-2016).

Methods: Using data from 5,467 participants from NHANES 2015-2016, we estimated the latest prevalence of gout and hyperuricemia. During the NHANES, all participants were asked about a history of health professional-diagnosed gout and medication use. Read More

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http://dx.doi.org/10.1002/art.40807DOI Listing
January 2019

Efficacy and safety during extended treatment of lesinurad in combination with febuxostat in patients with tophaceous gout: CRYSTAL extension study.

Arthritis Res Ther 2019 Jan 7;21(1). Epub 2019 Jan 7.

Hospital Universitario Cruces, Baracaldo, Vizcaya, Spain.

Background: In gout, long-term urate-lowering therapy (ULT) promotes dissolution of tissue urate crystal deposits. However, no studies using combined xanthine oxidase inhibition and uricosuric ULT have focused on clinical outcomes or adverse events (AEs) beyond 12 months of therapy. Our objective in the present study was to examine efficacy and long-term safety in patients with tophaceous gout receiving febuxostat plus lesinurad as combination therapy. Read More

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http://dx.doi.org/10.1186/s13075-018-1788-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322285PMC
January 2019

Unusual milia-type intradermal tophi in a patient with gout.

Korean J Intern Med 2018 Dec 31. Epub 2018 Dec 31.

Division of Rheumatology, Department of Internal Medicine, Gyeongsang National University Hospital, Jinju, Korea.

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http://dx.doi.org/10.3904/kjim.2018.352DOI Listing
December 2018

Associations between urate-lowering therapy and the risk of type 2 diabetes mellitus.

PLoS One 2019 7;14(1):e0210085. Epub 2019 Jan 7.

Department of Public Health, China Medical University, Taichung, Taiwan.

Background: Gout is independently associated with increased risk of type 2 diabetes mellitus (T2DM). Urate-lowering therapy (ULT) might be beneficial in lowering the risks of T2DM. Therefore, we conducted a nested case-control study to evaluate the associations between ULT and T2DM. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0210085PLOS
January 2019
1 Read

Patient Perceptions of Gout Management Goals: A Cross-sectional Internet Survey.

J Clin Rheumatol 2019 Jan 4. Epub 2019 Jan 4.

Department of Medicine, Division of Rheumatology, Immunology and Allergy, University of Florida, Gainesville, FL.

Objective: To assess patient perceptions of gout management goals.

Methods: We conducted a cross-sectional Internet survey of people who visited the Gout and Uric Acid Education Society's website to assess patient/respondent perception of gout management goals. We used chi-square test for categorical or t-test for continuous variables. Read More

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http://dx.doi.org/10.1097/RHU.0000000000000981DOI Listing
January 2019
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Extended Flight Bouts Require Disinhibition from GABAergic Mushroom Body Neurons.

Curr Biol 2018 Dec 22. Epub 2018 Dec 22.

National Centre for Biological Sciences, Tata Institute of Fundamental Research, Bangalore 560065, India. Electronic address:

Insect flight is a complex behavior that requires the integration of multiple sensory inputs with flight motor output. Although previous genetic studies identified central brain monoaminergic neurons that modulate Drosophila flight, neuro-modulatory circuits underlying sustained flight bouts remain unexplored. Certain classes of dopaminergic and octopaminergic neurons that project to the mushroom body, a higher integrating center in the insect brain, are known to modify neuronal output based on contextual cues and thereby organismal behavior. Read More

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http://dx.doi.org/10.1016/j.cub.2018.11.070DOI Listing
December 2018

Gouty Tophi in Sinus Tarsi of Bilateral Feet Mimicking Synovial Sarcoma:A Case Report.

J Foot Ankle Surg 2019 Jan 3. Epub 2019 Jan 3.

Director, Podiatric Surgical Residency, Beaumont Hospital Wayne, Wayne, MI.

Chronic gout is defined as accumulation of monosodium urate crystals in joints, cartilage, tendons, bursae, bone, and soft tissue. The foot is the most common location for acute gout flares, with the first metatarsophalangeal joint being the most frequent site of tophus formation. However, few studies have reported gouty tophus formation in the subtalar joint. Read More

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http://dx.doi.org/10.1053/j.jfas.2018.08.031DOI Listing
January 2019

Rhein, An Anthraquinone Drug, Suppresses the NLRP3 Inflammasome and Macrophage Activation in Urate Crystal-Induced Gouty Inflammation.

Am J Chin Med 2019 Jan 7:1-17. Epub 2019 Jan 7.

* Institute of Pharmacology, School of Medicine, National Yang-Ming University, Taipei, Taiwan.

Rhein, an anthraquinone drug, is a widely used traditional Chinese medicine. Rhein is a major bioactive metabolite of diacerein which has been approved for treating osteoarthritis with a good safety profile in humans. Gouty arthritis is an inflammatory disease characterized by urate crystal-induced NLRP3 inflammasome activation with up-regulated caspase-1 protease and IL-1 in macrophages. Read More

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https://www.worldscientific.com/doi/abs/10.1142/S0192415X195
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http://dx.doi.org/10.1142/S0192415X19500071DOI Listing
January 2019
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A Summary of 2018 and What Lies Ahead for Rheumatology and Therapy in 2019.

Authors:
Roy Fleischmann

Rheumatol Ther 2019 Jan 5. Epub 2019 Jan 5.

Metroplex Clinical Research Center, University of Texas Southwestern Medical Center, Dallas, USA.

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http://dx.doi.org/10.1007/s40744-018-0136-0DOI Listing
January 2019
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Potential dangers of serum urate-lowering therapy.

Am J Med 2019 Jan 3. Epub 2019 Jan 3.

Department of Nephrology and Hypertension, IIS-Fundacion Jimenez Diaz UAM, Madrid, Spain; REDINREN; Madrid, Spain; FRIAT, Madrid, Spain. Electronic address:

In observational studies, high serum urate levels are associated with adverse outcomes, including mortality. However, the hypothesis that urate lowering may improve non-gout outcomes has not been confirmed by placebo-controlled clinical trials. On the contrary, seven recent placebo-controlled trials of urate lowering drugs with different mechanisms of action (uricosuric: lesinurad; xanthine oxidase inhibition: febuxostat; uricase: pegloticase) have observed higher mortality or trends to higher mortality in gout patients with the largest decreases in serum urate. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00029343193000
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http://dx.doi.org/10.1016/j.amjmed.2018.12.010DOI Listing
January 2019
1 Read

Gout and the risk of Parkinson's disease in older adults: a study of U.S. Medicare data.

BMC Neurol 2019 Jan 5;19(1). Epub 2019 Jan 5.

Department of Medicine at School of Medicine, University of Alabama at Birmingham, Faculty Office Tower 805B, 510 20th Street S, Birmingham, AL, 35294-0022, USA.

Background: In the presence of limited available data, our objective was to assess the association of gout with the risk of incident Parkinson's disease (PD) in adults 65 years or older.

Methods: We used the 5% random sample of Medicare claims data from 2006 to 2012 to examine the association of gout with incident PD. The multivariable Cox regression model adjusted for demographics, comorbidity, and common cardiovascular disease and gout medications. Read More

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http://dx.doi.org/10.1186/s12883-018-1234-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6321725PMC
January 2019

Starvation-induced diplopia and weakness: a case of beriberi and Wernicke's encephalopathy.

BMJ Case Rep 2019 Jan 3;12(1). Epub 2019 Jan 3.

Department of Internal Medicine, Singapore General Hospital, Singapore.

A 56-year-old teetotaller man with hypertension and gout presented with a week duration of painless worsening diplopia on a background of loss of weight and appetite, generalised lethargy and weakness for 1 year. On examination, he was noted to be hypothermic and tachycardic with generalised muscle wasting. Proximal myopathy, lower limb fasciculations and areflexia, restricted bilateral eye abduction and nystagmus were observed. Read More

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http://dx.doi.org/10.1136/bcr-2018-227412DOI Listing
January 2019
5 Reads

Association and risk factors of chronic kidney disease and incident diabetes: a nationwide population-based cohort study.

Diabetologia 2019 Jan 3. Epub 2019 Jan 3.

Department of Internal Medicine, Changhua Christian Hospital, 135 Nanxiao Street, Changhua City, 500, Taiwan.

Aims/hypothesis: Chronic kidney disease (CKD) is a known complication of diabetes mellitus, and insulin resistance is a well-known complication of CKD. However, there is no consensus in the published data on the association of CKD with incident diabetes.

Methods: A total of 15,403 people with CKD were identified from the Taiwan National Health Insurance Research Database to determine their risk of incident diabetes compared with that of 15,403 matched individuals without CKD. Read More

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http://dx.doi.org/10.1007/s00125-018-4788-7DOI Listing
January 2019
2 Reads

Identification of the multivalent PDZ protein PDZK1 as a binding partner of sodium-coupled monocarboxylate transporter SMCT1 (SLC5A8) and SMCT2 (SLC5A12).

J Physiol Sci 2019 Jan 2. Epub 2019 Jan 2.

Department of Pharmacology, Chiba University Graduate School of Medicine, Chuo-ku, Chiba, Japan.

Sodium-coupled monocarboxylate transporters SMCT1 (SLC5A8) and SMCT2 (SLC5A12) mediate the high- and low-affinity transport of lactate in the kidney, but their regulatory mechanism is still unknown. Since these two transporters have the PDZ-motif at their C-terminus, the function of SMCTs may be modulated by a protein-protein interaction. To investigate the binding partner(s) of SMCTs in the kidney, we performed yeast two-hybrid (Y2H) screenings of a human kidney cDNA library with the C-terminus of SMCT1 (SMCT1-CT) and SMCT2 (SMCT2-CT) as bait. Read More

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http://link.springer.com/10.1007/s12576-018-00658-1
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http://dx.doi.org/10.1007/s12576-018-00658-1DOI Listing
January 2019
2 Reads

Anti-hyperuricemic effect of isorhamnetin in cultured hepatocytes and model mice: structure-activity relationships of methylquercetins as inhibitors of uric acid production.

Cytotechnology 2019 Jan 2. Epub 2019 Jan 2.

Center for Bioscience Research and Education, Utsunomiya University, Utsunomiya, Tochigi, 321-8505, Japan.

Hyperuricemia is an important risk factor for gout. Isorhamnetin (3'-O-methylquercetin) is an O-methylated flavonol, which occurs in onion, almond and sea buckthorn. It is also one of the metabolites of quercetin in mammals. Read More

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http://dx.doi.org/10.1007/s10616-018-0275-8DOI Listing
January 2019
1 Read

Anakinra for the treatment of acute gout flares: a randomized, double-blind, placebo-controlled, active-comparator, non-inferiority trial.

Rheumatology (Oxford) 2019 Jan 2. Epub 2019 Jan 2.

Arthritis Center Twente, Department of Psychology, Health and Technology, University of Twente, The Netherlands.

Objectives: To evaluate the efficacy and safety of anakinra in treating acute gout flares in a randomized, double-blind, placebo-controlled, active comparator, non-inferiority (NI) trial.

Methods: Patients with a crystal-proven acute gout flare were randomized (1: 1) to treatment with anakinra or treatment as usual (free choice: either colchicine, naproxen or prednisone). The primary end point was the change in pain between baseline and the averaged pain score on days 2-4 measured on a five-point rating scale. Read More

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http://dx.doi.org/10.1093/rheumatology/key402DOI Listing
January 2019
4.475 Impact Factor

Diagnostic advances in synovial fluid analysis and radiographic identification for crystalline arthritis.

Curr Opin Rheumatol 2018 Dec 27. Epub 2018 Dec 27.

Monica Zell and Dawen Zhang contributed equally to the work.

Purpose Of Review: The present review addresses diagnostic methods for crystalline arthritis including synovial fluid analysis, ultrasound, and dual energy CT scan (DECT).

Recent Findings: There are new technologies on the horizon to improve the ease, sensitivity, and specificity of synovial fluid analysis. Raman spectroscopy uses the spectral signature that results from a material's unique energy absorption and scatter for crystal identification. Read More

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http://dx.doi.org/10.1097/BOR.0000000000000582DOI Listing
December 2018
1 Read

Gout and cardiovascular disease: crystallized confusion.

Curr Opin Rheumatol 2018 Dec 27. Epub 2018 Dec 27.

Crystal Diseases Study Group, Division of Rheumatology, New York University School of Medicine, New York, USA.

Purpose Of Review: Gout is associated with the risk of cardiovascular morbidity and mortality, but the biological relationship between the two remains uncertain. The demonstration of reduction of cardiovascular risk with appropriate gout treatment would argue for a causal role for gout in cardiovascular disease. We reviewed recent studies that address the relationship between gout and cardiovascular disease. Read More

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http://dx.doi.org/10.1097/BOR.0000000000000585DOI Listing
December 2018

The role of febuxostat in gout.

Curr Opin Rheumatol 2018 Dec 27. Epub 2018 Dec 27.

Department of Rheumatology, Hôpital Lariboisière, APHP.

Purpose Of The Review: Concerns about the cardiovascular safety of febuxostat lead to reconsideration of the place of febuxostat in the management of gout.

Recent Findings: The CARES trial is a randomized controlled trial mandated by the FDA to compare the cardiovascular safety of febuxostat and allopurinol in the management of gout. About 6190 patients with gout and major cardiovascular disease, randomly assigned to allopurinol or febuxostat, were prospectively followed up for a median of 32 months. Read More

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http://dx.doi.org/10.1097/BOR.0000000000000573DOI Listing
December 2018
1 Read

Isolation, characterization, and xanthine oxidase inhibitory activities of flavonoids from the leaves of Perilla frutescens.

Nat Prod Res 2019 Jan 2:1-7. Epub 2019 Jan 2.

a Department of Natural Medicine and Pharmacognosy, School of Pharmacy , Qingdao University , Qingdao , China.

Phytochemical investigation of the water extract from the leaves of Perilla frutescens (Lamiaceae) led to the isolation of a new flavanone, a new chalcone, and a new aurone, namely, (2S)-5,7-dimethoxy-8,4'-dihydroxyflavanone (1), 2',4'-dimethoxy-4,5',6'-trihydroxychalcone (2), and (Z)-4,6-dimethoxy-7,4'-dihydroxyaurone (3), respectively. The structures were unambiguously elucidated on the basis of spectroscopic data. And the absolute configuration of 1 was determined by analysis of electronic circular dichroism spectrum. Read More

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http://dx.doi.org/10.1080/14786419.2018.1544981DOI Listing
January 2019
2 Reads
0.919 Impact Factor

Resveratrol ameliorates gouty inflammation via upregulation of sirtuin 1 to promote autophagy in gout patients.

Inflammopharmacology 2019 Jan 1. Epub 2019 Jan 1.

Department of Rheumatology and Immunology, The First Affiliated Hospital of Chengdu Medical College, Chengdu, 610500, Sichuan Province, China.

Background: Resveratrol exerts an anti-inflammatory effect on collagen-induced arthritis and osteoarthritis in rats via activation of sirtuin 1 (SIRT1). Autophagy can be induced by resveratrol and leads to amelioration of interleukin-1 beta (IL-1β) release in vitro. We aimed to determine the anti-inflammatory mechanisms of resveratrol in patients with gout. Read More

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http://dx.doi.org/10.1007/s10787-018-00555-4DOI Listing
January 2019

An experiential culture: A review on user, product, drinking and eating experiences in consumer research.

Food Res Int 2019 Jan 22;115:328-337. Epub 2018 Nov 22.

Centre des Sciences du Goût et de l'Alimentation, AgroSup Dijon, CNRS, INRA, Univ. Bourgogne Franche-Comté, F-21000 Dijon, France. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S09639969183092
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http://dx.doi.org/10.1016/j.foodres.2018.11.035DOI Listing
January 2019
2 Reads

A cross-cultural perspective on feeling good in the context of foods and beverages.

Food Res Int 2019 Jan 12;115:292-301. Epub 2018 Dec 12.

Sensometrics & Consumer Science, Instituto Polo Tecnológico de Pando, Facultad de Química, Universidad de la República, Uruguay.

The aim of the present research was to explore consumers' conceptualization of feeling good in relation to food and beverages from a cross-cultural perspective. Participants from 14 countries across 5 continents and covering 10 languages (N = 8325) responded to an online survey including word association and free listing tasks related to feeling good in the context of food and beverages. Results were analyzed using inductive coding: a list of main codes was generated in English for each of the tasks, after which native speakers for each language coded the responses. Read More

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http://dx.doi.org/10.1016/j.foodres.2018.12.012DOI Listing
January 2019
1 Read

Colchicine in Cardiovascular Disease: Repurposing an Ancient Gout Drug.

Authors:
Peter L Thompson

Clin Ther 2018 Dec 26. Epub 2018 Dec 26.

Heart Research Institute, Sir Charles Gairdner Hospital Medical School, University of Western Australia, Crawley, Western Australia, Australia; Harry Perkins Institute of Medical Research, Perth, Western Australia, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.clinthera.2018.11.014DOI Listing
December 2018

Tophus resolution in patients with chronic refractory gout who have persistent urate-lowering responses to pegloticase.

Arthritis Res Ther 2018 Dec 29;20(1):286. Epub 2018 Dec 29.

AMPEL BioSolutions, LLC, 250 West Main Street, Charlottesville, VA, 22902, USA.

Background: Pegloticase is a recombinant mammalian uricase conjugated to polyethylene glycol approved in the United States for treatment of chronic refractory gout. It can profoundly decrease serum urate to < 1 mg/dl. In patients receiving pegloticase who did not generate high-titer antidrug antibodies (responders), the serum urate remained low for the duration of therapy, 6 months in the phase III clinical trials plus the open-label extension. Read More

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http://dx.doi.org/10.1186/s13075-018-1782-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311031PMC
December 2018
1 Read

[Analysis of animal models based on clinical symptoms of gout].

Zhongguo Zhong Yao Za Zhi 2018 Nov;43(22):4547-4552

Henan University of Traditional Chinese Medicine, Zhengzhou 450046, China.

According to the characteristics of gout's clinical symptoms, the common gout animal models were analyzed, and the anastomosis and application prospect of the existing gout animal models with the clinical symptoms were discussed. At present, there are three models of gout: hyperuricemia model, gouty arthritis model and gouty nephropathy model. There are many methods of gout modeling, but there is a lack of animal model replication that could reflect the characteristics of gout's clinical symptoms and reflect the etiology of gout, and there is still a gap between the clinical symptoms and the clinical symptoms. Read More

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http://dx.doi.org/10.19540/j.cnki.cjcmm.20180625.005DOI Listing
November 2018
1 Read