18,891 results match your criteria Gout


Does any mother's body odor stimulate interest in mother's face in 4-month-old infants?

Infancy 2020 Mar 12;25(2):151-164. Epub 2020 Jan 12.

Laboratoire Développement, Individu, Processus, Handicap, Éducation (DIPHE), Département Psychologie du Développement, de l'Éducation et des Vulnérabilités (PsyDEV), Institut de psychologie, Université de Lyon (Lumière Lyon 2), Bron, France.

Little is known about the effects of olfaction on visual processing during infancy. We investigated whether and how an infant's own mother's body odor or another mother's body odor affects 4-month-old infants' looking at their mother's face when it is paired with a stranger's face. In Experiment 1, infants were exposed to their mother's body odor or to a control odor, while in Experiment 2, infants were exposed to a stranger mother's body odor while their visual preferences were recorded. Read More

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http://dx.doi.org/10.1111/infa.12322DOI Listing

Risk factors for cutaneous reactions to allopurinol in Kinh Vietnamese: results from a case-control study.

Arthritis Res Ther 2020 Aug 3;22(1):182. Epub 2020 Aug 3.

French Vietnamese Research Center on Gout and Chronic Diseases, Vien Gut Medical Centre, Ho Chi Minh City, Vietnam.

Objective: The aim of this study was to investigate risk factors for cutaneous adverse reactions (CARs) in Kinh Vietnamese.

Methods: All patients were prospectively recruited in Ho Chi Minh City. Presence of the HLA-B*58:01 allele was determined by real-time PCR-sequence-specific amplification by using the PG5801 Detection Kit (Pharmigene, Taipei). Read More

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http://dx.doi.org/10.1186/s13075-020-02273-1DOI Listing

Physical activity measured using wearable activity tracking devices associated with gout flares.

Arthritis Res Ther 2020 Aug 3;22(1):181. Epub 2020 Aug 3.

University of Alabama at Birmingham, 1720 2nd Avenue South, Birmingham, AL, 35294, USA.

Objective: To determine the feasibility and validity of using wearable activity trackers to test associations between gout flares with physical activity and sleep.

Methods: Participants with physician-diagnosed gout, hyperuricemia (≥ 6.8 mg/dl), current smartphone use, and ≥ 2 self-reported flares in the previous 6 months were enrolled. Read More

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http://dx.doi.org/10.1186/s13075-020-02272-2DOI Listing

Efficacy of Rebixiao Chinese herbal tablets and Chinese formula granules in acute gout arthritis patients: a randomized, multicenter, double-blind, controlled trial.

J Tradit Chin Med 2020 Aug;40(4):664-673

Department of Rheumatology, Chongqing Hospital of Traditional Chinese Medicine, Chongqing 400021, China.

Objective: To evaluate the clinical efficacy and safety of Rebixiao (RBX) Chinese herbal tablets (CHT) and Chinese formula granules (CFG) in the treatment of acute gout arthritis (AGA).

Methods: This randomized, multicenter, double-blind, controlled trial included 165 AGA patients with the damp-heat symptom pattern who were randomly divided into an RBX CHT group and an RBX CFG group and treated for 7 d at three centers. The total effective rates of the joint symptom score, Traditional Chinese Medicine (TCM) symptoms score, erythrocyte sedimentation rate (ESR), and C-reactive protein (CRP) were used to evaluate the clinical efficacy. Read More

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http://dx.doi.org/10.19852/j.cnki.jtcm.2020.04.016DOI Listing

Tophaceous gout of the middle ear.

J Otol 2019 Dec 28;14(4):155-157. Epub 2019 Aug 28.

Department of Otolaryngogy, Head and Neck Surgery, Foundation Adolphe de Rothschild Hospital, Paris, France.

We present a very rare case of tophaceous gout of the middle ear causing conductive hearing loss, with special emphasis on Computed Tomography presentation. Read More

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http://dx.doi.org/10.1016/j.joto.2019.08.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7387856PMC
December 2019

Comparative efficacy and safety of pharmacological interventions in patients experiencing a gout flare: a systematic review and network meta-analysis.

Arthritis Care Res (Hoboken) 2020 Aug 2. Epub 2020 Aug 2.

Department of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, Canada.

Objective: To compare the relative efficacy and safety of pharmacological anti-inflammatory interventions for gout flares.

Methods: We searched Ovid Medline, Embase and Cochrane library for randomized controlled trials (RCTs) that compared pharmacological anti-inflammatory treatment of gout flares. We conducted a network meta-analysis (NMA) using a frequentist framework, and assessed the certainty of evidence and made conclusions using the GRADE for NMA. Read More

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http://dx.doi.org/10.1002/acr.24402DOI Listing

A Review of Neutrophil Extracellular Traps (NETs) in Disease: Potential Anti-NETs Therapeutics.

Clin Rev Allergy Immunol 2020 Aug 1. Epub 2020 Aug 1.

Department of Pathology, Microbiology, and Immunology, School of Veterinary Medicine, University of California Davis, 1 Shields Ave, Davis, CA, USA.

Activated neutrophils release neutrophil extracellular traps (NETs) in response to a variety of stimuli. NETosis is driven by protein-arginine deiminase type 4, with the release of intracellular granule components that function by capturing and destroying microbes, including viral, fungal, bacterial, and protozoal pathogens. The positive effects of pathogen control are countered by pro-inflammatory effects as demonstrated in a variety of diseases. Read More

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http://dx.doi.org/10.1007/s12016-020-08804-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7395212PMC

Enhancement of saltiness perception by odorants selected from Chinese soy sauce: A gas chromatography/olfactometry-associated taste study.

Food Chem 2020 Jul 26;335:127664. Epub 2020 Jul 26.

School of Food Science and Engineering, South China University of Technology, Guangzhou 510640, China; Guangdong Food Green Proc & Nutr Regulat Technol, Guangzhou 510640, China. Electronic address:

Odor-taste interaction has become a popular salt reduction method. In this study, the odorants associated with saltiness in soy sauce were selected by gas chromatography/olfactometry-associated taste (GC/O-AT), and their ability to induce saltiness/umami enhancement was verified by sensory evaluation. A total of 30 taste-associated odorants were perceived, including 5 saltiness-associated and 2 umami-associated odorants. Read More

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http://dx.doi.org/10.1016/j.foodchem.2020.127664DOI Listing

Hyperuricaemia and gout in cardiovascular, metabolic and kidney disease.

Eur J Intern Med 2020 Jul 29. Epub 2020 Jul 29.

National and Kapodistrian University of Athens, Athens 15772, Greece.

During the last century, there has been an increasing prevalence of hyperuricaemia noted in many populations. While uric acid is usually discussed in the context of gout, hyperuricaemia is also associated with hypertension, chronic kidney disease, hypertriglyceridaemia, obesity, atherosclerotic heart disease, metabolic syndrome, and type 2 diabetes. Here we review the connection between hyperuricaemia and cardiovascular, kidney and metabolic diseases. Read More

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http://dx.doi.org/10.1016/j.ejim.2020.07.006DOI Listing

MicroRNA and long noncoding RNA involvement in gout and prospects for treatment.

Int Immunopharmacol 2020 Jul 29;87:106842. Epub 2020 Jul 29.

Jiangsu Key Laboratory of Bioactive Natural Product Research and State Key Laboratory of Natural Medicines, China Pharmaceutical University, 24 Tong Jia Xiang, Nan Jing 210009, China. Electronic address:

MicroRNAs (miRNAs) and long noncoding RNAs (lncRNAs) are both types of noncoding RNA. They have been demonstrated to be involved in the regulation of various human inflammatory diseases and can be used as biomarkers for disease diagnosis and prognosis, and even be developed into new drugs. Gout is an arthritic disease caused by the deposition of monosodium urate crystal (MSU) in the joints, which can lead to acute inflammation and damage adjacent tissue. Read More

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http://dx.doi.org/10.1016/j.intimp.2020.106842DOI Listing

Comparative analysis of the efficacy of angiotensin II receptor blockers for uric acid level change in asymptomatic hyperuricaemia.

J Clin Pharm Ther 2020 Aug 1. Epub 2020 Aug 1.

Division of Biomedical Informatics, Systems Biomedical Informatics Research Centre, Seoul National University College of Medicine, Seoul, Korea.

What Is Known And Objective: There is much controversy over how angiotensin II receptor blockers (ARB) or angiotensin-converting enzyme inhibitors (ACEI) affect blood uric acid levels. Though ARB is not used to lorcwer the uric acid concentration in the blood, losartan, one of the ARB series, is known to reduce the uric acid concentration in the blood and is a preferred drug for hypertensive patients with gout. However, there is no clear conclusive consideration which ARB should be selected for the patients who have simply increased uric acid concentration, other than gout patients. Read More

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http://dx.doi.org/10.1111/jcpt.13202DOI Listing

Diabetes Mellitus Is Associated with a Lower Risk of Gout: A Meta-Analysis of Observational Studies.

J Diabetes Res 2020 9;2020:5470739. Epub 2020 Jul 9.

Department of Internal Medicine, Hebei Medical University, Shijiazhuang 050017, China.

Aims: Although several epidemiological studies have investigated the relationship between diabetes mellitus (DM) and the risk of gout, the results are inconsistent. Therefore, we systematically retrospected available observational studies to clarify the impact of DM on the risk of gout.

Methods: Embase, PubMed, Cochrane Library, Scopus, Web of Science, and China National Knowledge Infrastructure were searched for relevant articles from inception to 2 March 2020. Read More

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http://dx.doi.org/10.1155/2020/5470739DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7369651PMC

Colchicine Alleviates Cholesterol Crystal-Induced Endothelial Cell Pyroptosis through Activating AMPK/SIRT1 Pathway.

Oxid Med Cell Longev 2020 15;2020:9173530. Epub 2020 Jul 15.

The Key Laboratory of Myocardial Ischemia Organization, Chinese Ministry of Education, Harbin, Heilongjiang 150086, China.

Cholesterol crystal- (CC-) induced endothelial cell inflammation and pyroptosis play an important role in the development of cardiovascular diseases, especially in atherosclerosis (AS). Increasing evidence suggests that cholesterol crystals are known to be a pivotal pathological marker of atherosclerotic plaque vulnerability. As a classical nonspecific anti-inflammatory drug, colchicine has been widely used in the treatment of acute gout. Read More

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http://dx.doi.org/10.1155/2020/9173530DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7378601PMC

Cardiovascular safety risks associated with gout treatments.

Expert Opin Drug Saf 2020 Jul 30. Epub 2020 Jul 30.

University of Alabama at Birmingham Department of Medicine, Birmingham, Alabama, United States.

Introduction: Uric acid is the final byproduct of purine metabolism. Along the evolutionary process, the loss of the enzyme that hydrolyzes uric acid to allantoin was lost, leading to a decrease in uric acid excretion and its further accumulation. The buildup of uric acid leads to damage in different organ systems, including the cardiovascular system. Read More

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http://dx.doi.org/10.1080/14740338.2020.1804551DOI Listing

Cherry extracts attenuate inflammation and oxidative stress triggered by monosodium urate crystals in THP-1 cells.

J Food Biochem 2020 Jul 29:e13403. Epub 2020 Jul 29.

Laboratorio de Líquido Sinovial, Instituto Nacional de Rehabilitación "Luis Guillermo Ibarra-Ibarra (INR-LGII), México City, México.

The microwaves-assisted extraction (MAE) for concentration of cherry phytochemicals has seen explored. Polyphenols from cherries, Prunus avium (L.) L. Read More

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http://dx.doi.org/10.1111/jfbc.13403DOI Listing

Acute Gouty Arthritis During Favipiravir Treatment for Coronavirus Disease 2019: A Case Report.

Intern Med 2020 Jul 28. Epub 2020 Jul 28.

Department of Infectious Diseases, Japanese Red Cross Narita Hospital, Japan.

A 42-year-old man exhibiting hypoxia was diagnosed with coronavirus disease 2019. He had medical histories of type 2 diabetes, hyperlipidemia, hyperuricemia, and gout attack. He received favipiravir for compassionate use for 14 days. Read More

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http://dx.doi.org/10.2169/internalmedicine.5377-20DOI Listing

Natural Products and Extracts as Xantine Oxidase Inhibitors - A Hope for Gout Disease?

Curr Pharm Des 2020 Jul 28. Epub 2020 Jul 28.

Department of Pharmacognosy, Faculty of Pharmacy, Gazi University, 06330 Ankara. Turkey.

Xanthine oxidase (EC 1.17.3. Read More

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http://dx.doi.org/10.2174/1381612826666200728144605DOI Listing

Increased Efficacy and Tolerability of Pegloticase in Patients With Uncontrolled Gout Co-Treated With Methotrexate: A Retrospective Study.

Rheumatol Ther 2020 Jul 27. Epub 2020 Jul 27.

Horizon Therapeutics plc, 150 S. Saunders Road, Lake Forest, IL, USA.

Introduction: Gout is a painful inflammatory condition caused by chronically elevated serum uric acid levels (sUA). When standard urate-lowering therapies fail/are not tolerated, uncontrolled gout (elevated sUA, subcutaneous tophi, chronic gouty arthritis, frequent flares) can occur. Pegloticase, a recombinant uricase, converts uric acid to allantoin, a readily excreted molecule. Read More

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http://dx.doi.org/10.1007/s40744-020-00222-7DOI Listing

Adrenocorticotropic hormone: an effective "natural" biologic therapy for acute gout?

Rheumatol Int 2020 Jul 26. Epub 2020 Jul 26.

Department of Rheumatology, Patras University Hospital, University of Patras Medical School, Patras, Greece.

Treatment of acute gout consists of non-steroidal anti-inflammatory drugs (NSAIDs), colchicine and steroids. However, the typical patient with gout has multiple comorbidities such as cardiovascular disease, hypertension, renal dysfunction or diabetes/metabolic syndrome that represent contraindications to these therapeutic options. The aim of this study is to review the available evidence regarding the use of ACTH as an alternative therapeutic option for acute gout and explore potential mechanisms of action. Read More

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http://dx.doi.org/10.1007/s00296-020-04659-5DOI Listing

Correction to: Anakinra for colchicine-intolerant/colchicine-resistant acute gout flare precipitated by decompensated heart failure.

Ir J Med Sci 2020 Jul 23. Epub 2020 Jul 23.

Department of Rheumatology, Albany Medical College, Albany, NY, USA.

The published version of the original article has the corresponding author last name switched with first name. Read More

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http://dx.doi.org/10.1007/s11845-020-02323-2DOI Listing

Response to 2020 American College of Rheumatology Guideline for the Management of Gout.

Arthritis Care Res (Hoboken) 2020 Jul 23. Epub 2020 Jul 23.

Medicine, Rutger-Robert Wood Johnson Medical School, New Brunswick, United States, Charlottesville.

We reviewed the 2020 American College of Rheumatology (ACR) Guideline for the Management of Gout with interest. First, we want to commend the committee for the excellent job they did in updating the guidelines. We noted the commitment to evidence- based medicine and also that the indications for starting urate-lowering therapy (ULT) have been expanded to consider patients with infrequent gout flares or a first gout flare if they also have moderate to severe chronic kidney disease (CKD stage ≥ 3), marked hyperuricemia (serum urate (SU) > 9 mg/dl) or kidney stones. Read More

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http://dx.doi.org/10.1002/acr.24379DOI Listing

Achievement of the target serum urate level among patients with gout treated with allopurinol or febuxostat in an arthritis clinic in the Philippines.

Mod Rheumatol 2020 Jul 23:1-18. Epub 2020 Jul 23.

Division of Rheumatology, Department of Medicine, University of the Philippines Manila, Philippine General Hospital, Philippines.

Gout is an important cause of disability among Filipinos, despite measures for effective management. This study aims to determine attainment of target serum uric acid level (SUA ≤6 mg/dl) among patients with gout given urate- lowering therapy (ULT) over 6 to 12 months. This is a single-center, prospective cohort study conducted in one adult Arthritis Clinic at the University of the Philippines- Philippine General Hospital which included 138 patients with gout (1977 ACR criteria), SUA ≥6 mg/dl prior to ULT, initiated on ULT (allopurinol or febuxostat), with six months minimum follow-up and with SUA determination post-treatment. Read More

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http://dx.doi.org/10.1080/14397595.2020.1800557DOI Listing

Gout and pseudo-gout-related crystals promote GLUT1-mediated glycolysis that governs NLRP3 and interleukin-1β activation on macrophages.

Ann Rheum Dis 2020 Jul 22. Epub 2020 Jul 22.

Universite de Paris, Paris, France

Objective: Macrophage activation by monosodium urate (MSU) and calcium pyrophosphate (CPP) crystals mediates an interleukin (IL)-1β-dependent inflammation during gout and pseudo-gout flare, respectively. Since metabolic reprogramming of macrophages goes along with inflammatory responses dependently on stimuli and tissue environment, we aimed to decipher the role of glycolysis and oxidative phosphorylation in the IL-1β-induced microcrystal response.

Methods: Briefly, an in vitro study (metabolomics and real-time extracellular flux analysis) on MSU and CPP crystal-stimulated macrophages was performed to demonstrate the metabolic phenotype of macrophages. Read More

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http://dx.doi.org/10.1136/annrheumdis-2020-217342DOI Listing

Gout in primary healthcare: still a long way to go.

Curr Med Res Opin 2020 Jul 22. Epub 2020 Jul 22.

Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.

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http://dx.doi.org/10.1080/03007995.2020.1799774DOI Listing

Ultrasound for the diagnosis of gout-the value of gout lesions as defined by the Outcome Measures in Rheumatology ultrasound group.

Rheumatology (Oxford) 2020 Jul 22. Epub 2020 Jul 22.

Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, Glostrup.

Objective: To evaluate ultrasound for diagnosing gout using consensus-based Outcome Measures in Rheumatology ultrasound definitions of gout lesions.

Methods: Ultrasound was performed in patients with clinically suspected gout. Joints (28) and tendons (26) were binarily evaluated for the Outcome Measures in Rheumatology gout lesions-double contour (DC), tophus, aggregates and erosions. Read More

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http://dx.doi.org/10.1093/rheumatology/keaa366DOI Listing

Gout: Where Is the Weak Link?

J Clin Rheumatol 2020 Aug;26(5):208-212

From the Department of Medicine, University Miguel Hernandez, Elche.

In the field of rheumatic and musculoskeletal diseases, no other condition has evolved so significantly since the mid-1950s as gout. In this period, the cause of gout has been firmly established; the close relationship with other conditions clarified; a rapid, unequivocal diagnostic test established; and agents effective in dissolving monosodium urate crystals and controlling inflammation made widely available. All these insights have ultimately led to deem gout as curable, an end point formerly considered out of reach. Read More

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http://dx.doi.org/10.1097/RHU.0000000000001492DOI Listing

Can gout management guidelines be solely evidence based?

Nat Rev Rheumatol 2020 Jul 20. Epub 2020 Jul 20.

Department of Rheumatology, Hôpital Lariboisière, Paris, France.

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http://dx.doi.org/10.1038/s41584-020-0471-8DOI Listing

Identification of GLUT12/SLC2A12 as a urate transporter that regulates the blood urate level in hyperuricemia model mice.

Proc Natl Acad Sci U S A 2020 Aug 20;117(31):18175-18177. Epub 2020 Jul 20.

Department of Pharmacy, The University of Tokyo Hospital, Bunkyo-ku, 113-8655 Tokyo, Japan.

Recent genome-wide association studies have revealed some genetic loci associated with serum uric acid levels and susceptibility to gout/hyperuricemia which contain potential candidates of physiologically important urate transporters. One of these novel loci is located upstream of and , suggesting that variations in these genes increase the risks of hyperuricemia and gout. We herein focused on encoding a transporter, GLUT12, the physiological function of which remains unclear. Read More

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http://dx.doi.org/10.1073/pnas.2006958117DOI Listing

Efficacy and Safety of Bempedoic Acid in Patients With Hypercholesterolemia: Systematic Review and Meta-Analysis of Randomized Controlled Trials.

J Am Heart Assoc 2020 Aug 21;9(15):e016262. Epub 2020 Jul 21.

Department of Translational Medical Sciences Federico II University Naples Italy.

Background Bempedoic acid (BA) is a novel lipid-lowering drug. We performed a systematic review and meta-analysis on efficacy and safety of BA compared with standard treatment in patients with hypercholesterolemia. Methods and Results Studies were systematically searched in the PubMed, Web of Science, Scopus, and EMBASE databases. Read More

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http://dx.doi.org/10.1161/JAHA.119.016262DOI Listing
August 2020
2.882 Impact Factor

Associations of serum uric acid level and gout with cardiac structure, function and sex differences from large scale asymptomatic Asians.

PLoS One 2020 20;15(7):e0236173. Epub 2020 Jul 20.

Division of Cardiology, Department of Internal Medicine, MacKay Memorial Hospital, Taipei, Taiwan.

Hyperuricemia (HU) is a marker for heart failure. There are relatively few data in the Asian population regarding the effects of hyperuricemia and gouty disorders on cardiac remodeling and diastolic dysfunction (DD), an intermediate stage in the development of heart failure. We consecutively recruited asymptomatic Asian individuals to undergo cardiovascular surveys. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0236173PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7371161PMC

Management of ulcerated finger pad tophi.

Reumatologia 2020 29;58(3):173-178. Epub 2020 Jun 29.

Department of Plastic Surgery, Shri Ram Murti Smarak Institute of Medical Sciences, Bareilly, Uttar Pradesh, India.

Finger pad tophi are an unusual but not very rare presentation of uncontrolled gout. Unlike tophaceous lesions of other locations, finger pad tophi are often difficult to diagnose at presentation due to resemblance to a variety of nodular lesions, coexistence with other connective tissue disorders and sometimes occurrence in asymptomatic hyperuricemia. They also pose a therapeutic dilemma due to a lack of clear treatment guidelines. Read More

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http://dx.doi.org/10.5114/reum.2020.96631DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7362275PMC

The potential effect of Ramadan fasting on musculoskeletal diseases: new perspectives.

Clin Rheumatol 2020 Jul 18. Epub 2020 Jul 18.

Rheumatology Department, Kassab Orthopedics Institute, Ksar Said, Tunisia.

Ramadan, the ninth month of the Muslim lunar calendar, is a period of intermittent fasting alternated with moments of refeeding. The last decades have seen a growing number of reports that examine the potential effect of Ramadan intermittent fasting (RIF) on chronic musculoskeletal disorders. In this paper, we reviewed data that assessed the relationship of intermittent diurnal fasting during Ramadan with rheumatic diseases. Read More

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http://dx.doi.org/10.1007/s10067-020-05297-9DOI Listing

Occupational exposure to inorganic dust and risk of gout: a population-based study.

RMD Open 2020 Jul;6(2)

Occupational and Environmental Medicine, School of Public Health and Community Medicine, Sahlgrenska Academy, University of Gothenburg, Goteborg, Sweden.

Background: Risk factors operating independently of hyperuricemia could be of importance in determining why only a minority of people with hyperuricemia develop gout. Exposure to inorganic dust has been linked to other inflammatory diseases and could influence the development of gout.

Objectives: To evaluate if occupational exposure to inorganic dust increases the risk of gout. Read More

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http://dx.doi.org/10.1136/rmdopen-2020-001178DOI Listing

[Delays in the management of ocular complications of giant cell arteritis: A retrospective monocentric study of 33 patients].

Rev Med Interne 2020 Jul 16. Epub 2020 Jul 16.

Service de Neuro-Ophtalmologie, Hôpital Fondation Adolphe de Rothschild, 75019 Paris, France; Service des Urgences Ophtalmologiques, Hôpital Fondation Adolphe de Rothschild, 75019 Paris, France.

Introduction: Ocular complications of giant cell arteritis (GCA) can lead to irreversible bilateral blindness and represent a therapeutic emergency. Recommendations for the management of GCA have recently been updated. The objective of the study was to evaluate delays in appropriate management of the ocular complications of GCA and its determinants. Read More

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http://dx.doi.org/10.1016/j.revmed.2020.06.012DOI Listing

Regulation of catechins on uric acid metabolism disorder related human diseases.

Mini Rev Med Chem 2020 Jul 18. Epub 2020 Jul 18.

College of Horticulture, South China Agricultural University, Guangzhou 510000. China.

Background: Uric acid is the end product of purine metabolism in humans. High uric acid levels form sodium urate crystals that trigger biological processes, which lead to the development of several diseases, including diabetes, hyperuricemia, gout, inflammatory disease, kidney disease, cardiovascular disease and hypertension. Catechins have been suggested to be beneficial for the regulation of uric acid metabolic disorders due to their powerful antioxidant and antiinflammatory properties. Read More

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http://dx.doi.org/10.2174/1389557520666200719015919DOI Listing

Breast malignancy in female-to-male transsexuals: systematic review, case report, and recommendations for screening.

Breast 2020 Jul 2;53:92-100. Epub 2020 Jul 2.

Medisch Centrum Bloemendaal, Zomerzorgerlaan 50, Bloemendaal, the Netherlands.

Background: Female-to-male (FtM) transsexuals may use testosterone therapy for masculinization, which potentially influences the risk of breast cancer development. Guided by our case report, we aimed to investigate the evidence regarding the risk of testosterone therapy on breast malignancy in female-to-male transsexuals and evaluate breast cancer screening in this subgroup.

Methods: We conducted a systematic literature search according to the PRISMA checklist in June 2020 in PubMed/MEDLINE and Ovid/EMBASE. Read More

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http://dx.doi.org/10.1016/j.breast.2020.06.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7375644PMC

Association of MASP2 levels and MASP2 gene polymorphisms with systemic lupus erythematosus.

J Cell Mol Med 2020 Jul 17. Epub 2020 Jul 17.

Department of Rheumatology and Immunology, Affiliated Hospital of Southwest Medical University, Luzhou, China.

Systemic lupus erythematosus (SLE) is a chronic inflammatory autoimmune disorder. MASP2 is a mediator that plays an important role in complement system. As dysregulation of the complement system has been demonstrated to correlate with SLE pathogenesis, the role of MASP2 in lupus has not been widely discussed. Read More

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http://dx.doi.org/10.1111/jcmm.15656DOI Listing

Characteristics of Acute Gout Flare in Patients Initiated on Intravenous Bumetanide for Acute Heart Failure Exacerbation.

Cureus 2020 Jun 13;12(6):e8605. Epub 2020 Jun 13.

Rheumatology, Einstein Medical Center, Philadelphia, USA.

Background Heart failure is a clinical syndrome with significant morbidity, mortality, and financial burden. These factors are magnified in patients with associated comorbidities. Therefore, addressing such conditions is critical in decreasing healthcare costs and improving patient outcomes. Read More

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http://dx.doi.org/10.7759/cureus.8605DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7362594PMC

Uric acid fluctuation had no effect on renal function among gout patients.

Nutr Metab Cardiovasc Dis 2020 Jun 20. Epub 2020 Jun 20.

Department of Public Health, and Department of Anesthesiology, the Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China. Electronic address:

Background And Aims: To investigate the effects of serum uric acid (SUA) level and its fluctuation on renal dysfunction in gout patients.

Methods And Results: Data on gout patients was collected from Huzhou city electronic medical record system data sharing platform, and information about relevant diagnoses, prescriptions, biochemical indexes and imaging characteristics was extracted. The gout patients with baseline normal renal function were enrolled in this analysis, and the estimated glomerular filtration rate (eGFR) < 60 mL/min/1. Read More

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http://dx.doi.org/10.1016/j.numecd.2020.06.008DOI Listing

NSAIDs detected in Iberian avian scavengers and carrion after diclofenac registration for veterinary use in Spain.

Environ Pollut 2020 Jul 3;266(Pt 2):115157. Epub 2020 Jul 3.

Instituto de Investigación en Recursos Cinegéticos (IREC), CSIC-UCLM-JCCM, 13005, Ciudad Real, Spain.

Despite the now well recognised impact of diclofenac on vultures across the Indian subcontinent, this non-steroidal anti-inflammatory drug (NSAID) was registered in 2013 for livestock treatment in Spain, Europe's main vulture stronghold. We assessed the risk of exposure to diclofenac and nine other NSAIDs in avian scavengers in the Iberian Peninsula (Spain and Portugal) after the onset of diclofenac commercialization. We sampled 228 livestock carcasses from vulture feeding sites, primarily pig (n = 156) and sheep (n = 45). Read More

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http://dx.doi.org/10.1016/j.envpol.2020.115157DOI Listing

Ultrasound shows rapid reduction of crystal depositions during a treat-to-target approach in gout patients: 12-month results from the NOR-Gout study.

Ann Rheum Dis 2020 Jul 15. Epub 2020 Jul 15.

Department of Rheumatology, Diakonhjemmet Sykehus, Oslo, Norway.

Objectives: As ultrasound is sensitive for detecting crystal depositions in patients with gout, our objectives were to explore the main locations for depositions and the extent of dissolution of depositions during a treat-to-target approach with urate lowering treatment (ULT) in patients with gout.

Methods: Patients with a recent flare of gout were consecutively included in this single-centre study and managed by a treat-to-target approach with ULT. All patients were assessed at baseline, 3, 6 and 12 months including bilateral ultrasound examinations of joints/tendons/entheses of hands, elbows, knees, ankles and feet. Read More

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http://dx.doi.org/10.1136/annrheumdis-2020-217392DOI Listing

[Gout arthritis: Pathogenesis, diagnostics and treatment].

Authors:
Gernot Keyßer

Dtsch Med Wochenschr 2020 Jul 15;145(14):991-1005. Epub 2020 Jul 15.

The initial presentation of gouty arthritis can be a dramatic event. Chronic gout may lead to the destruction of joints, invalidity and increased mortality. The incidence of this disorder is high, despite effective therapeutic measures. Read More

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http://dx.doi.org/10.1055/a-1036-8348DOI Listing

Rebranding Gout: Could a Name Change for Gout Improve Adherence to Urate-Lowering Therapy?

Ther Innov Regul Sci 2020 Jul 13. Epub 2020 Jul 13.

St Vincent's Clinical School, UNSW Medicine, UNSW Sydney, Sydney, Australia.

Gout is the most common form of inflammatory arthritis in men, yet both patients and the public often do not recognise gout as a form of arthritis. Instead, due to historical misconceptions, gout is typically seen as a lifestyle disease caused by poor diet. In reality, there are a number of risk factors that contribute to gout, including genetic factors. Read More

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http://dx.doi.org/10.1007/s43441-020-00198-0DOI Listing

Comparison of efficacy and safety of urate-lowering therapies for hyperuricemic patients with gout: a meta-analysis of randomized, controlled trials.

Clin Rheumatol 2020 Jul 11. Epub 2020 Jul 11.

Department of Medicine, Division of Rheumatology, Rutgers-Robert Wood Johnson Medical School, New Brunswick, NJ, 08901, USA.

Objectives: To assess the efficacy and safety of the commonly used urate-lowering therapies (ULTs): febuxostat, allopurinol, and lesinurad in hyperuricemic patients with gout.

Methods: We included all randomized controlled trials (RCTs) that compared ULTs with placebo or head to head. The primary efficacy endpoint was the proportion of subjects achieving the target serum urate (SU) level at month 6. Read More

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http://dx.doi.org/10.1007/s10067-020-05272-4DOI Listing
July 2020
1.774 Impact Factor

Initiating guideline-concordant gout treatment improves arterial endothelial function and reduces intercritical inflammation: a prospective observational study.

Arthritis Res Ther 2020 Jul 11;22(1):169. Epub 2020 Jul 11.

Section of Rheumatology, VA New York Harbor Health Care System, New York, NY, USA.

Background: Patients with gout have arterial dysfunction and systemic inflammation, even during intercritical episodes, which may be markers of future adverse cardiovascular outcomes. We conducted a prospective observational study to assess whether initiating guideline-concordant gout therapy with colchicine and a urate-lowering xanthine oxidase inhibitor (XOI) improves arterial function and reduces inflammation.

Methods: Thirty-eight untreated gout patients meeting American College of Rheumatology (ACR)/European League Against Rheumatism classification criteria for gout and ACR guidelines for initiating urate-lowering therapy (ULT) received colchicine (0. Read More

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http://dx.doi.org/10.1186/s13075-020-02260-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7353742PMC

Artificial intelligence to predict clinical disability in patients with multiple sclerosis using FLAIR MRI.

Diagn Interv Imaging 2020 Jul 7. Epub 2020 Jul 7.

Observatoire Français de la Sclérose en Plaques, Centre de Recherche en Neurosciences de Lyon, INSERM 1028 et CNRS UMR 5292, 69003 Lyon, France; Department of Radiology, Centre Hospitalier Lyon-Sud, Hospices Civils de Lyon, 69310 Pierre-Bénite, France; CREATIS, CNRS UMR 5220, INSERM U1044, 69622 Villeurbanne, France.

Purpose: The purpose of this study was to create an algorithm that combines multiple machine-learning techniques to predict the expanded disability status scale (EDSS) score of patients with multiple sclerosis at two years solely based on age, sex and fluid attenuated inversion recovery (FLAIR) MRI data.

Materials And Methods: Our algorithm combined several complementary predictors: a pure deep learning predictor based on a convolutional neural network (CNN) that learns from the images, as well as classical machine-learning predictors based on random forest regressors and manifold learning trained using the location of lesion load with respect to white matter tracts. The aggregation of the predictors was done through a weighted average taking into account prediction errors for different EDSS ranges. Read More

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http://dx.doi.org/10.1016/j.diii.2020.05.009DOI Listing

Pan-spinal cord compression from gout: Visual vignette of a young male patient with three spinal decompressive surgeries.

Am J Phys Med Rehabil 2020 Jul 6. Epub 2020 Jul 6.

Singapore General Hospital, Outram Road, Singapore 169608 Singapore General Hospital, Outram Road, Singapore 169608 Singapore General Hospital, Outram Road, Singapore 169608.

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http://dx.doi.org/10.1097/PHM.0000000000001524DOI Listing
July 2020
2.012 Impact Factor

Surgical Site Gout 12 Years After an Achilles Tendon Repair: A Case Report.

JBJS Case Connect 2020 Jul-Sep;10(3):e1900283

1Hawaii Island Family Medicine Residency Program, Hilo, Hawaii 2Hilo Community Surgery Center and Hilo Orthopedics, Hilo, Hawaii.

Case: We report a 58-year-old woman with no history of gout who subsequently developed gouty tophi around retained suture material identified 12 ½ years after repair of a ruptured Achilles tendon. The patient had intermittently developed an apparent postsurgical infection at and around the incision site. She had normal uric acid levels. Read More

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http://dx.doi.org/10.2106/JBJS.CC.19.00283DOI Listing

Allopurinol prescription patterns among patients in a Saudi tertiary care centre.

J Taibah Univ Med Sci 2020 Jun 27;15(3):185-189. Epub 2020 Apr 27.

Doctor Soliman Fakeeh Hospital, Jeddah, KSA.

Objective: Physicians frequently prescribe allopurinol for uric acid deposition disorders. However, reports have emerged of the inappropriate use and overprescription of allopurinol. We conducted this study to determine the rate of inappropriate prescription of allopurinol in a Saudi institution. Read More

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http://dx.doi.org/10.1016/j.jtumed.2020.03.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7336014PMC