18,291 results match your criteria Gonorrhea


Clonal expansion and spread of the ceftriaxone-resistant Neisseria gonorrhoeae strain FC428, identified in Japan in 2015, and closely related isolates.

J Antimicrob Chemother 2019 Apr 19. Epub 2019 Apr 19.

Department of Bacteriology I, National Institute of Infectious Diseases, Tokyo, Japan.

Objectives: Ceftriaxone resistance in Neisseria gonorrhoeae is a major public health concern globally because a high-dose (1 g) injection of ceftriaxone is the only remaining option for empirical monotherapy of gonorrhoea. The ceftriaxone-resistant gonococcal strain FC428, cultured in Osaka in 2015, is suspected to have spread nationally and internationally. We describe the complete finished genomes of FC428 and two closely related isolates from Osaka in 2015, and examine the genomic epidemiology of these isolates plus three ceftriaxone-resistant gonococcal isolates from Osaka and Hyogo in 2016-17 and four ceftriaxone-resistant gonococcal isolates cultured in 2017 in Australia, Canada and Denmark. Read More

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http://dx.doi.org/10.1093/jac/dkz129DOI Listing

Superimposing incident sexually transmitted infections on HIV phylogram to investigate possible misclassification of men who have sex with men as heterosexuals in a cohort in Antwerp, Belgium.

Int J STD AIDS 2019 Apr 4;30(5):486-495. Epub 2019 Feb 4.

1 Department of Clinical Sciences, Institute of Tropical Medicine, Antwerp, Belgium.

In this study, we assessed if the superimposition of incident sexually transmitted infections (STIs) on HIV phylogenetic analyses could reveal possible sexual behaviour misclassifications in our HIV-infected population. HIV-1 sequences collected between 1997 and 2014 from 1169 individuals attending a HIV clinic in Antwerp, Belgium were analysed to infer a partial HIV transmission network. Individual demographic, clinical and laboratory data collected during routine HIV follow-up were used to compare clustered and non-clustered individuals using logistic regression analyses. Read More

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http://journals.sagepub.com/doi/10.1177/0956462418821752
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http://dx.doi.org/10.1177/0956462418821752DOI Listing
April 2019
1 Read

Evidence for a new paradigm of gonorrhoea transmission: cross-sectional analysis of infections by anatomical site in both partners in 60 male couples.

Sex Transm Infect 2019 Apr 17. Epub 2019 Apr 17.

Melbourne Sexual Health Centre, Carlton, Victoria, Australia.

Objective: Gonorrhoea transmission between men is currently thought to occur primarily to and from the urethra. Transmission without urethral involvement, from throat-to-throat and throat-to-anus, is considered to be uncommon. Using gonorrhoea results from male couples, we aimed to investigate the transmission dynamics of gonorrhoea. Read More

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http://dx.doi.org/10.1136/sextrans-2018-053803DOI Listing
April 2019
3.401 Impact Factor

Trends and Characteristics Associated with HPV Vaccination Uptake Among Men Who Have Sex with Men in the United States, 2014 - 2017.

Sex Transm Dis 2019 Apr 15. Epub 2019 Apr 15.

Department of Epidemiology, Rollins School of Public Health, Emory University; Atlanta, GA.

Background: Human papillomavirus (HPV) and HPV-associated cancer rates are high among men who have sex with men (MSM). The US Advisory Committee on Immunization Practices (ACIP) recommends HPV vaccination for all MSM through age 26. We examined trends in HPV vaccine uptake among young US MSM between 2014-2017. Read More

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http://dx.doi.org/10.1097/OLQ.0000000000001008DOI Listing

A double strand break does not promote pilin antigenic variation.

J Bacteriol 2019 Apr 15. Epub 2019 Apr 15.

Department of Microbiology-Immunology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611

The major subunit of the Type IV pilus (T4p) of undergoes Antigenic variation (Av) dependent on a guanine quadruplex (G4) DNA structure located upstream of the pilin gene. Since the presence of G4 DNA induces genome instability in both eukaryotic and prokaryotic chromosomes, we tested whether a double strand break (DSB) at the site of the G4 sequence can substitute for G4 directed pilin Av. The G4 motif was replaced by an I-SceI cut site and the cut site was also introduced to locations near the origin of replication and the terminus. Read More

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http://jb.asm.org/lookup/doi/10.1128/JB.00256-19
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http://dx.doi.org/10.1128/JB.00256-19DOI Listing
April 2019
6 Reads

Location, Location, Location-Commensalism, Damage and Evolution of the Pathogenic Neisseria.

Authors:
H Steven Seifert

J Mol Biol 2019 Apr 12. Epub 2019 Apr 12.

Department of Microbiology-Immunology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA. Electronic address:

The 10 human-restricted Neisseria species all colonize mucosal surfaces, but show a spectrum of pathogenicity. The commensal Neisseria do not normally cause pathology, while the two pathogenic species, Neisseria meningitidis and Neisseria gonorrhoeae, straddle the border between commensalism and pathogenicity. Why the pathogenic Neisseria continue to mediate host damage after thousands of years of co-evolution with their human host, and why the commensal species have not acquired the ability to damage the host, if this capability provides a selective advantage, is not understood. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00222836193018
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http://dx.doi.org/10.1016/j.jmb.2019.04.007DOI Listing
April 2019
2 Reads

Improving Tracking of Postdischarge Results of Sexually Transmitted Infection Screening Tests in Hospitalized Adolescents and Young Adults: A Quality Improvement Initiative.

Sex Transm Dis 2019 May;46(5):354-356

Division of Pediatric Hospitalist Medicine, Department of Pediatrics, Children's Hospital at Montefiore, Albert Einstein College of Medicine, Bronx, NY.

Hospitalizations offer chlamydia and gonorrhea screening opportunities for youth who may not seek preventive care. Tracking of screening test results still pending after hospital discharge is an important component of clinical care. This process can be improved by protocol use and enhanced by effective, automated electronic health record tools. Read More

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http://dx.doi.org/10.1097/OLQ.0000000000000973DOI Listing

Efficacy and Safety of Single-Dose Oral Delafloxacin Compared With Intramuscular Ceftriaxone for Uncomplicated Gonorrhea Treatment: An Open-Label, Noninferiority, Phase 3, Multicenter, Randomized Study.

Sex Transm Dis 2019 May;46(5):279-286

Melinta Therapeutics, Lincolnshire, IL.

Background: We evaluated single oral dose of delafloxacin versus single intramuscular ceftriaxone in participants with uncomplicated urogenital gonorrhea (primary objective). Secondary objectives included the efficacy, safety, and tolerability of delafloxacin versus ceftriaxone for uncomplicated urogenital, rectal, and/or pharyngeal gonorrhea.

Methods: In this open-label, multicenter study, 460 participants at 25 study centers were randomized (2:1) to receive a single 900-mg oral dose of delafloxacin or 250-mg intramuscular ceftriaxone. Read More

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http://dx.doi.org/10.1097/OLQ.0000000000000971DOI Listing

Australian Gonococcal Surveillance Programme Annual Report, 2017

Commun Dis Intell (2018) 2019 Apr 15;43. Epub 2019 Apr 15.

Neisseria Reference Laboratory and World Health Organisation Collaborating Centre for STI and AMR, Sydney. New South Wales Health Pathology, Microbiology, The Prince of Wales Hospital, Randwick, NSW Australia.

The Australian Gonococcal Surveillance Programme (AGSP) has continuously monitored antimicrobial resistance in clinical isolates of Neisseria gonorrhoeae from all states and territories since 1981. In 2017, there were 7,835 clinical isolates of gonococci from public and private sector sources tested for in vitro antimicrobial susceptibility by standardised methods. Current treatment recommendations for gonorrhoea for the majority of Australia, is a dual therapeutic strategy of ceftriaxone and azithromycin. Read More

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April 2019
1 Read

High burden of chlamydia and gonorrhoea in pharyngeal, rectal and urethral sites among Thai transgender women: implications for anatomical site selection for the screening of STI.

Sex Transm Infect 2019 Apr 13. Epub 2019 Apr 13.

PREVENTION, Thai Red Cross AIDS Research Centre, Bangkok, Thailand.

Objective: Comprehensive data on (CT) and (NG) infections to guide screening services among transgender women (TGW) are limited. We studied the burden of CT/NG infections in pharyngeal, rectal and urethral sites of Thai TGW and determined missed CT/NG diagnoses if selected site screening was performed.

Methods: Thai TGW were enrolled to the community-led test and treat cohort. Read More

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http://dx.doi.org/10.1136/sextrans-2018-053835DOI Listing
April 2019
1 Read

Borderline personality disorder is associated with an increased risk of sexually transmitted infections: A nationwide population-based cohort study in Taiwan.

Sex Transm Infect 2019 Apr 13. Epub 2019 Apr 13.

Department of Psychiatry, Tzu Chi General Hospital, and School of Medicine, Tzu Chi University, Hualien, Taiwan

Background: Several features of borderline personality disorder (BPD) are likely to be associated with sexual health problems, such as unstable attachment, unstable sexual identity and sexual impulsivity. Since the issue of sex is not openly discussed in Taiwanese society, sexual health needs, including screening and prevention of sexually transmitted infections (STI), are often neglected in this population.

Objective: The study aims to determine whether BPD is associated with an increased risk of subsequent STI in Taiwan. Read More

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http://sti.bmj.com/lookup/doi/10.1136/sextrans-2018-053812
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http://dx.doi.org/10.1136/sextrans-2018-053812DOI Listing
April 2019
8 Reads

Rates of new HIV diagnoses after Reported STI, Women in Louisiana 2000-2015: Implications for HIV Prevention.

Clin Infect Dis 2019 Apr 12. Epub 2019 Apr 12.

Division of STD Prevention, National Center for HIV, Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta GA.

Background: Interventions to prevent HIV in women include screening, partner notification, promoting condoms, and pre-exposure prophylaxis (PrEP). Identifying a woman's risk of acquiring HIV can help guide intervention recommendations.

Methods: We used data from Louisiana's STI and HIV registries to study 13- to 59-year-old women following their first diagnosis of syphilis, (or if none) gonorrhea, or (if none) chlamydia during 2000-2015. Read More

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http://dx.doi.org/10.1093/cid/ciz303DOI Listing

Extragenital Chlamydia and Gonorrhea Among Community Venue-Attending Men Who Have Sex with Men - Five Cities, United States, 2017.

MMWR Morb Mortal Wkly Rep 2019 Apr 12;68(14):321-325. Epub 2019 Apr 12.

Sexually transmitted diseases (STDs) disproportionately affect gay, bisexual, and other men who have sex with men (MSM) in the United States (1). Because chlamydia and gonorrhea at extragenital (rectal and pharyngeal) anatomic sites are often asymptomatic, these anatomic sites serve as a reservoir of infection, which might contribute to gonococcal antimicrobial resistance (2) and increased risk for human immunodeficiency virus (HIV) transmission and acquisition (3). To ascertain prevalence of extragenital STDs, MSM attending community venues were recruited in five U. Read More

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http://dx.doi.org/10.15585/mmwr.mm6814a1DOI Listing
April 2019
1 Read

Association of HIV Preexposure Prophylaxis With Incidence of Sexually Transmitted Infections Among Individuals at High Risk of HIV Infection.

JAMA 2019 04;321(14):1380-1390

Disease Elimination Program, Burnet Institute, Melbourne, Victoria, Australia.

Importance: Emerging evidence suggests that risk of bacterial sexually transmitted infections (STIs) increases among gay and bisexual men following initiation of HIV preexposure prophylaxis (PrEP).

Objective: To describe STI incidence and behavioral risk factors among a cohort of predominantly gay and bisexual men who use PrEP, and to explore changes in STI incidence following PrEP commencement.

Design, Setting, And Participants: The Pre-exposure Prophylaxis Expanded (PrEPX) Study, a multisite, open-label intervention study, was nested within the Australian Collaboration for Coordinated Enhanced Sentinel Surveillance (ACCESS) clinic network. Read More

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http://dx.doi.org/10.1001/jama.2019.2947DOI Listing
April 2019
3 Reads

Il n'y a pas d'amour heureux pour Casanova: Chemical- and bio-analysis of his Memoirs.

Electrophoresis 2019 Apr 8. Epub 2019 Apr 8.

Department of Chemistry, Materials and Chemical Engineering ''Giulio Natta'', Politecnico di Milano, Milano, Italy.

The original manuscript of Casanova's Memoirs is stored at the Bibliothèque Nationale de France in Paris. We have gained access to it and explored the surfaces of chapters one and two (via the ethylene vinyl acetate [EVA] film technology, i.e. Read More

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http://dx.doi.org/10.1002/elps.201800505DOI Listing
April 2019
1 Read

Rationale for a Neisseria gonorrhoeae Susceptible Only Interpretive Breakpoint for Azithromycin.

Clin Infect Dis 2019 04 9. Epub 2019 Apr 9.

Departments of Medicine and Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.

Background: Azithromycin (AZI) is recommended with Ceftriaxone (CRO) for treatment of uncomplicated gonococcal urethritis and cervicitis in the United States (US) and an AZI susceptibility breakpoint is needed. Neither the FDA (Food and Drug Administration) nor the CLSI (Clinical and Laboratory Standards Institute) has set interpretive breakpoints for AZI susceptibility. As a result, AZI antimicrobial susceptibility testing (AST) cannot be interpreted using recognized standards. Read More

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http://dx.doi.org/10.1093/cid/ciz292DOI Listing
April 2019
1 Read

Health implications of sex trading characteristics in Long Beach, California, USA.

Int J STD AIDS 2019 Apr 8:956462419828138. Epub 2019 Apr 8.

6 Office of Research, Pacific University, Forest Grove, OR, USA.

This study examined the comparative health risk behaviors of women who (a) traded sex for money, (b) traded sex for drugs, (c) traded sex for both drugs and money, or (d) did not trade sex. Self-report data were collected from 2369 women who received services through HIV and sexually transmitted infection (STI) testing programs and a subset were tested for HIV, hepatitis B, hepatitis C, and syphilis. Results revealed those women who traded sex only for money used condoms, were tested for HIV, and received the HIV test results more often than the other women. Read More

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http://dx.doi.org/10.1177/0956462419828138DOI Listing
April 2019
1 Read

Prevalence of HIV/STIs and correlates with municipal characteristics among female sex workers in 13 Mexican cities.

Salud Publica Mex 2019 Mar-Apr;61(2):116-124

Departamento de Cuidado Integral, Centro Nacional para la Prevención y el Control del VIH y el Sida, Secretaría de Salud. Mexico City, Mexico.

Objective: To identify correlates of HIV/STI prevalence among 13 cities with varying sizes of female sex worker (FSW) populations and municipal characteristics in Mexico.

Materials And Methods: FSWs underwent interviews and testing for HIV, syphilis, gonorrhea and chlamydia. Logistic regression explored variations in HIV/STI prevalence. Read More

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http://dx.doi.org/10.21149/8863DOI Listing
June 2017
1 Read

Population-level antimicrobial consumption is associated with decreased antimicrobial susceptibility in Neisseria gonorrhoeae in 24 European countries: an ecological analysis.

J Infect Dis 2019 Apr 8. Epub 2019 Apr 8.

WHO Collaborating Centre for Gonorrhoea and other Sexually Transmitted Infections, Department of Laboratory Medicine, Faculty of Medicine and Health, Örebro University, Örebro, Sweden.

Objectives: There are substantial variations in Neisseria gonorrhoeae susceptibility to antimicrobials between different populations, and the reasons for this are largely unexplored. We aimed to assess if the population level consumption of antimicrobials is a contributory factor.

Methods: Using antimicrobial susceptibility data from 24 countries in the European Gonococcal Antimicrobial Surveillance Programme and antimicrobial consumption data from the IQVIA MIDAS database, we built mixed effects linear/logistic regression models with country-level cephalosporin, fluoroquinolone and macrolide consumption (standard doses/1000 population/year) as the explanatory variables (from 2009 to 2015) and 1-year lagged ceftriaxone, cefixime, azithromycin and ciprofloxacin geometric mean minimum inhibitory concentrations (MIC) as the outcome variables (2010 to 2016). Read More

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http://dx.doi.org/10.1093/infdis/jiz153DOI Listing

Gonorrhoea and chlamydia in persons with HIV: number needed to screen.

Sex Transm Infect 2019 Apr 6. Epub 2019 Apr 6.

Department of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.

Objectives: Current guidelines recommend screening sexually active persons with HIV (PWH) for (NG) and (CT) at least annually. Yet, screening rates in many HIV clinics remain low. In this study, we estimated the number needed to screen (NNS) to detect a NG and/or CT infection at each anatomic site among different subpopulations of PWH. Read More

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http://sti.bmj.com/lookup/doi/10.1136/sextrans-2018-053793
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http://dx.doi.org/10.1136/sextrans-2018-053793DOI Listing
April 2019
2 Reads

Screening for Gonorrhea and Chlamydia in Pregnancy: Room for Improvement.

J Obstet Gynaecol Can 2019 Apr 2. Epub 2019 Apr 2.

Department of Obstetrics and Gynaecology, St. Michael's Hospital, University of Toronto, Toronto, ON.

Objective: This study sought to determine the proportion of pregnant women who are tested for gonorrhea and chlamydia as part of their prenatal care and to examine patient and provider factors affecting testing rates.

Methods: The study investigators conducted a retrospective chart review of all patients who were delivered at St. Michael's Hospital, an urban tertiary care centre in Toronto, Ontario, between November 2015 and April 2016. Read More

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http://dx.doi.org/10.1016/j.jogc.2019.02.006DOI Listing

Addressing gaps in the management of Chlamydia trachomatis and Neisseria gonorrhoea in primary care: lessons learned in a pilot intervention study.

Sex Transm Dis 2019 Apr 3. Epub 2019 Apr 3.

Department of Primary Health Care and General Practice, University of Otago, Wellington, PO Box 7343, Wellington South 6242, New Zealand.

Background: Partner notification, follow-up and re-testing help to interrupt the transmission and health consequences of sexually transmitted infections (STIs) like chlamydia and gonorrhoea, but for a range of reasons are not routinely undertaken in primary care. This pilot study aimed to test the acceptability and utility of strategies designed to facilitate the delivery of clinical best practice for patients diagnosed with chlamydia or gonorrhoea in primary care.

Methods: A non-randomised pilot intervention study with a historic control period was run over nine months in six primary health care clinics in Wellington, New Zealand. Read More

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http://dx.doi.org/10.1097/OLQ.0000000000001005DOI Listing

Defining characteristics of genital health in South African adolescent girls and young women at high risk for HIV infection.

PLoS One 2019 4;14(4):e0213975. Epub 2019 Apr 4.

Institute of Infectious Disease and Molecular Medicine (IDM), University of Cape Town, Cape Town, South Africa.

The genital tract of African women has been shown to differ from what is currently accepted as 'normal', defined by a pH≤4.5 and lactobacilli-dominated microbiota. Adolescent girls and young women (AGYW) from sub-Saharan Africa are at high risk for HIV, and we hypothesized that specific biological factors are likely to be influential. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0213975PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448899PMC
April 2019
3 Reads

Prevalence and factors associated with gonorrhea infection with respect to anatomic distributions among men who have sex with men.

PLoS One 2019 3;14(4):e0211682. Epub 2019 Apr 3.

Family Physician, Department of Microbiology, Faculty of Medicine, Srinagarind Hospital, Khon Kaen University, Thailand.

Introduction: Gonorrhea (GC) infection caused by Neisseria gonorrhoeae has been steadily increasing in Thailand over the last decade. Men who have sex with men (MSM) are at high risk for gonorrhea infection.

Materials And Methods: In this study, we determined the prevalence of and risk factors associated with gonococcal infections by three anatomical sites among MSM. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0211682PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447148PMC

Sexually Transmitted Diseases in the Emergency Department.

Emerg Med Clin North Am 2019 May;37(2):165-192

Prisma Health, University of South Carolina School of Medicine Greenville, 701 Grove Road, Greenville, SC 29605, USA. Electronic address:

Sexually transmitted diseases (STDs) continue to be underrecognized leading to devastating health and economic consequences. Emergency clinicians play an important role in diagnosing and managing STDs and in improving health care outcomes for both the patient and their partners. In addition, antibiotic resistance and emerging infections continue to challenge providers in clinical practice. Read More

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http://dx.doi.org/10.1016/j.emc.2019.01.001DOI Listing
May 2019
1 Read

Trends in diagnosis of pelvic inflammatory disease in an Australian sexual health clinic, 2002-16: before and after clinical audit feedback.

Sex Health 2019 Apr 3. Epub 2019 Apr 3.

A 2006 Australian sexual health clinic audit of pelvic inflammatory disease (PID) diagnosis rates found variability between doctors. Doctors were given audit feedback towards increasing diagnosis and reducing variability. The clinic implemented other improvements to increase capacity. Read More

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http://dx.doi.org/10.1071/SH18119DOI Listing
April 2019
3 Reads

Evaluation of the BD MAX™ Vaginal Panel for the detection of vaginal infections in a sexual health service in the UK.

Authors:
Jackie Sherrard

Int J STD AIDS 2019 Mar 8;30(4):411-414. Epub 2019 Jan 8.

Department of Sexual Health, Buckinghamshire Healthcare NHS Trust, Wycombe General Hospital, Wycombe, UK.

The aim of this study is to compare the performance of the BD MAX™ Vaginal Panel (Becton, Dickinson and company, Franklin Lakes, NJ, USA) in the diagnosis of bacterial vaginosis (BV), candidiasis and trichomoniasis with current standard tests in a UK specialist sexual health service. Women with abnormal vaginal discharge attending the service who had not used douches or vaginal treatment in the preceding 48 hours had two vulvovaginal swabs taken: one for Chlamydia and gonorrhoea nucleic acid amplification test (NAAT) and one for testing on the BD MAX™ Vaginal Panel on the BD MAX System. Speculum examination was then performed and vaginal swabs taken for vaginal pH, and microscopy of vaginal secretions: Gram stain for Candida and BV using the Hay-Ison score and wet-mount for clue cells and Trichomonas vaginalis (TV). Read More

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http://dx.doi.org/10.1177/0956462418815284DOI Listing
March 2019
2 Reads

Bacterial sexually transmitted infections.

J Dtsch Dermatol Ges 2019 Mar;17(3):287-315

WIR "Walk In Ruhr", competence network HIV/AIDS, Center for Sexual Health and Medicine, Department of Dermatology, Venereology and Allergology, Ruhr University, Bochum, Germany.

Worldwide, the incidence of bacterial sexually transmitted infections (STIs) has shown a significant increase in recent years. In Germany, this circumstance is reflected by a rise in the number of reported syphilis cases. There has also been an uptick in the incidence of non-notifiable STIs such as gonorrhea and infections caused by Chlamydia trachomatis and Mycoplasma genitalium. Read More

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http://dx.doi.org/10.1111/ddg.13804DOI Listing
March 2019
2 Reads

Evolving patterns of reactive arthritis.

Clin Rheumatol 2019 Mar 27. Epub 2019 Mar 27.

Department of Medicine, Schulich School of Medicine & Dentistry, Western University, London, Canada.

Objective: To characterize rheumatologists' perspectives on evolving trends of reactive arthritis (ReA).

Methods: After ethics approval, 548 members of the Canadian Rheumatology Association were surveyed with 37 questions covering their demographic information, subspecialty, level of experience, practice setting and opinions on prevalence, treatment, and causes of ReA. Results were analyzed with descriptive statistics. Read More

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http://dx.doi.org/10.1007/s10067-019-04522-4DOI Listing
March 2019
1 Read

Predictive factors for HIV infection among men who have sex with men and who are seeking PrEP: a secondary analysis of the PROUD trial.

Sex Transm Infect 2019 Mar 27. Epub 2019 Mar 27.

Medical Research Council Clinical Trials Unit at University College London, London, UK.

Objectives: Pre-exposure prophylaxis (PrEP) is a highly effective method of HIV prevention for men who have sex with men (MSM). However, uncertainty remains around the optimal eligibility criteria for PrEP, specifically whether there are subgroups at low risk of HIV for whom PrEP might not be warranted.

Methods: PROUD was an open-label waitlist trial design that randomised MSM attending participating sexual health centres in England to receive PrEP immediately (IMM) or after a deferral period of 1 year (DEF). Read More

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http://dx.doi.org/10.1136/sextrans-2018-053808DOI Listing
March 2019
1 Read

Emergence of Neisseria gonorrhoeae Strains Harboring a Novel Combination of Azithromycin-Attenuating Mutations.

Antimicrob Agents Chemother 2019 Apr 27;63(4). Epub 2019 Mar 27.

Centers for Disease Control and Prevention, Atlanta, Georgia, USA.

The nimbleness of to evade the effect of antibiotics has perpetuated the fight against antibiotic-resistant gonorrhea for more than 80 years. The ability to develop resistance to antibiotics is attributable to its indiscriminate nature in accepting and integrating exogenous DNA into its genome. Here, we provide data demonstrating a novel combination of the 23S rRNA A2059G mutation with a mosaic-multiple transferable resistance (mosaic-) locus haplotype in 14 isolates with high-level azithromycin MICs (≥256 μg/ml), a combination that may confer more fitness than in previously identified isolates with high-level azithromycin resistance. Read More

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http://aac.asm.org/lookup/doi/10.1128/AAC.02313-18
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http://dx.doi.org/10.1128/AAC.02313-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437510PMC
April 2019
2 Reads

Sexually transmitted infections, active component, U.S. Armed Forces, 2010-2018.

MSMR 2019 Mar;26(3):2-10

This report summarizes incidence rates of the 5 most common sexually transmitted infections (STIs) among active component service members of the U.S. Armed Forces during 2010-2018. Read More

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March 2019
1 Read

Ten years of external quality assessment (EQA) of Neisseria gonorrhoeae antimicrobial susceptibility testing in Europe elucidate high reliability of data.

BMC Infect Dis 2019 Mar 25;19(1):281. Epub 2019 Mar 25.

WHO Collaborating Centre for Gonorrhoea and other STIs, Örebro University, Örebro, Sweden.

Background: Confidence in any diagnostic and antimicrobial susceptibility testing data is provided by appropriate and regular quality assurance (QA) procedures. In Europe, the European Gonococcal Antimicrobial Susceptibility Programme (Euro-GASP) has been monitoring the antimicrobial susceptibility in Neisseria gonorrhoeae since 2004. Euro-GASP includes an external quality assessment (EQA) scheme as an essential component for a quality-assured laboratory-based surveillance programme. Read More

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http://dx.doi.org/10.1186/s12879-019-3900-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434634PMC
March 2019
1 Read
2.613 Impact Factor

Antimicrobial susceptibility of Neisseria gonorrhoeae isolates and treatment of gonorrhoea patients in Ternopil and Dnipropetrovsk regions of Ukraine, 2013-2018.

APMIS 2019 Mar 23. Epub 2019 Mar 23.

WHO Collaborating Centre for Gonorrhoea and other STIs, National Reference Laboratory for STIs, Department of Laboratory Medicine, Faculty of Medicine and Health, Örebro University, Örebro, Sweden.

Antimicrobial resistance (AMR) in Neisseria gonorrhoeae is a major public health concern globally. However, recent gonococcal AMR data from Eastern Europe are extremely limited and no AMR data for strains spreading in Ukraine has ever been internationally published. We investigated the AMR of N. Read More

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http://dx.doi.org/10.1111/apm.12948DOI Listing
March 2019
2 Reads

Assessing the Burden of Chlamydia and Gonorrhea for Deployed and Active Duty Personnel Assigned Outside the USA.

Mil Med 2019 Mar;184(Supplement_1):21-27

EpiData Center, Navy and Marine Corps Public Health Center, 620 John Paul Jones Circle, Suite 100, Portsmouth, VA.

Sexually transmitted infections (STIs) have posed a threat to military service members throughout history, but limited evidence describes current sexually transmitted infection burden for personnel in-theater and stationed abroad. This study assessed chlamydia and gonorrhea rates by unit of country assignment and evaluated the demographic profile of affected personnel during deployment. Chlamydia and gonorrhea cases among active duty personnel were identified from laboratory results and ambulatory encounter records in the Military Health System from fiscal years October 2006 through September 2015; these were linked to personnel and deployment records to ascertain demographic characteristics, unit of country assignment, and if the case was captured during a period of deployment. Read More

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http://dx.doi.org/10.1093/milmed/usy366DOI Listing
March 2019
1 Read

Sexually Transmitted Infection Among Adolescents and Young Adults With Bipolar Disorder: A Nationwide Longitudinal Study.

J Clin Psychiatry 2019 Mar 12;80(2). Epub 2019 Mar 12.

Department of Psychiatry, No. 201, Shih-Pai Rd, Sec. 2, 11217, Taipei, Taiwan.

Background: Evidence has shown a significant association between bipolar disorder and prevalence of risky sexual behaviors. However, the relationship between bipolar disorder and risk for sexually transmitted infections (STIs) requires further investigation, as do the effects of bipolar disorder medications on STI risk.

Methods: In the present study, data from 26,028 adolescents and young adults with bipolar disorder (ICD-9-CM code 296 except 296. Read More

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http://dx.doi.org/10.4088/JCP.18m12199DOI Listing
March 2019
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5.498 Impact Factor

Acceptability of self-collecting oropharyngeal swabs for sexually transmissible infection testing among men and women.

Sex Health 2019 Mar 22. Epub 2019 Mar 22.

In 2016, the rate of USA gonorrhoea and chlamydia cases increased by 18.6% and 6.9% respectively. Read More

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http://dx.doi.org/10.1071/SH18209DOI Listing

Evaluation of the ResistancePlus GC (beta) assay: a commercial diagnostic test for the direct detection of ciprofloxacin susceptibility or resistance in Neisseria gonorrhoeae.

J Antimicrob Chemother 2019 Mar 20. Epub 2019 Mar 20.

Faculty of Medicine, Centre for Clinical Research, The University of Queensland, Herston, Queensland, Australia.

Objectives: To evaluate the performance of the ResistancePlus GC (beta) assay for the simultaneous detection of Neisseria gonorrhoeae and gyrA S91 markers of resistance (S91F) and susceptibility (WT) to ciprofloxacin, from both clinical specimens and isolates.

Methods: Performance was assessed on several sample banks, including N. gonorrhoeae isolates (n = 822), non-gonococcal isolates (n = 110), N. Read More

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http://dx.doi.org/10.1093/jac/dkz108DOI Listing
March 2019
3 Reads

Emergency Department Testing Patterns for Sexually Transmitted Diseases in North Texas.

Sex Transm Dis 2019 Mar 20. Epub 2019 Mar 20.

Department of Clinical Sciences, UT Southwestern Medical Center.

Background: Little is known about population-level sexually transmitted disease (STD) testing in emergency departments. We sought to explore STD testing patterns in emergency departments (EDs) in a large, urban metroplex in North Texas, a high prevalence region.

Methods: ED claims data were extracted from the Dallas Fort Worth Hospital Council databank for patients attending 54 EDs in four counties (Dallas, Tarrant, Collin, and Denton) who were tested for an STD during an ED visit between July 2014 and June 2015. Read More

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http://dx.doi.org/10.1097/OLQ.0000000000001003DOI Listing
March 2019
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[Mercury or sarsaparilla. On the pharmacotherapy of venereal diseases by Johannes Franc (1649-1725) and Friedrich Hoffmann (1660-1742)].

Urologe A 2019 Mar 20. Epub 2019 Mar 20.

Institut für Geschichte, Theorie und Ethik der Medizin, Universität Ulm, Parkstraße 11, 89073, Ulm, Deutschland.

In the late 17th and early 18th centuries, ancient humoral pathology was gradually complemented by new concepts of medical theory. Two important theories that emerged in this context were iatrochemistry and iatrophysics. The physician Johannes Franc (1649-1725) from Ulm and Friedrich Hoffmann (1660-1742), the first professor of the medical faculty of the Fridericiana in Halle (Saale), are representatives of these concepts. Read More

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http://link.springer.com/10.1007/s00120-019-0908-3
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http://dx.doi.org/10.1007/s00120-019-0908-3DOI Listing
March 2019
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Summary and Trends of the Russian Gonococcal Antimicrobial Surveillance Programme, 2005-2016.

J Clin Microbiol 2019 Mar 20. Epub 2019 Mar 20.

State Research Center of Dermatovenerology and Cosmetology, Moscow, Russia

The Russian Gonococcal Antimicrobial Surveillance Programme (RU-GASP) was established in 2004 and operated continuously during the years 2005-2016. The aims of this study were to summarize the RU-GASP results over this 12-year period and evaluate the trends in antimicrobial resistance in Russia. In total, 5,038 verified isolates from 40 participating regions were tested for susceptibility to six antimicrobials via an agar dilution method. Read More

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http://dx.doi.org/10.1128/JCM.02024-18DOI Listing
March 2019
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Does including violent crime rates in ecological regression models of sexually transmissible infection rates improve model quality? Insights from spatial regression analyses.

Sex Health 2019 Mar 19. Epub 2019 Mar 19.

Violent crime rates are often correlated with the hard-to-measure social determinants of sexually transmissible infections (STIs). In this study, we examined whether including violent crime rate as an independent variable can improve the quality of ecological regression models of STIs. We obtained multiyear (2008-12) cross-sectional county-level data on violent crime and three STIs (chlamydia, gonorrhoea, and primary and secondary (P&S) syphilis) from counties in all the contiguous states in the US (except Illinois and Florida, due to lack of data). Read More

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http://www.publish.csiro.au/?paper=SH17221
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http://dx.doi.org/10.1071/SH17221DOI Listing
March 2019
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Reply to "Comment on Effectiveness of a Group B Outer Membrane Vesicle Meningococcal Vaccine in Preventing Hospitalization from Gonorrhea in New Zealand: A Retrospective Cohort Study, Vaccines, 2019, 1, 5; doi:10.3390/vaccines7010005".

Vaccines (Basel) 2019 Mar 15;7(1). Epub 2019 Mar 15.

Immunisation Advisory Centre, Department of General Practice and Primary Health Care, University of Auckland, Auckland, 1142, New Zealand.

Kenyon (2019) is correct to suggest that there is limited evidence of longer term effectiveness.[.. Read More

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http://dx.doi.org/10.3390/vaccines7010032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6466234PMC
March 2019
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Comment on "Effectiveness of a Group B outer membrane vesicle meningococcal vaccine in preventing hospitalization from gonorrhea in New Zealand: a retrospective cohort study, , 2019, 1, 5; doi:10.3390/vaccines7010005".

Authors:
Chris Kenyon

Vaccines (Basel) 2019 Mar 14;7(1). Epub 2019 Mar 14.

HIV/STI Unit, Institute of Tropical Medicine, 2000 Antwerp, Belgium.

Available evidence suggests MeNZB™ is not associated with a durable effect against . Read More

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http://dx.doi.org/10.3390/vaccines7010031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6466146PMC
March 2019
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Targeting Lipooligosaccharide (LOS) for a Gonococcal Vaccine.

Front Immunol 2019 27;10:321. Epub 2019 Feb 27.

Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, MA, United States.

The increasing incidence of gonorrhea worldwide and the global spread of multidrug-resistant strains of , constitute a public health emergency. With dwindling antibiotic treatment options, there is an urgent need to develop safe and effective vaccines. Gonococcal lipooligosaccharides (LOSs) are potential vaccine candidates because they are densely represented on the bacterial surface and are readily accessible as targets of adaptive immunity. Read More

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http://dx.doi.org/10.3389/fimmu.2019.00321DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6400993PMC
February 2019
3 Reads

Human Immunodeficiency Virus Diagnosis After a Syphilis, Gonorrhea, or Repeat Diagnosis Among Males Including non-Men Who Have Sex With Men: What Is the Incidence?

Sex Transm Dis 2019 Apr;46(4):271-277

Department of Medicine, Johns Hopkins School of Medicine.

Background: The release of the first drug for human immunodeficiency virus (HIV) preexposure prophylaxis (PrEP) in 2012 marked the beginning of a new era of HIV prevention. Although PrEP is highly efficacious, identifying and ultimately increasing uptake among the highest risk male subgroups remains a challenge.

Methods: Public health surveillance data from 2009 to 2016 was used to evaluate the risk of an HIV diagnosis after a syphilis (ie, primary, secondary, or early latent), gonorrhea, and repeat diagnoses among urban males, including men who have sex with men (MSM) and non-MSM in Baltimore City. Read More

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http://dx.doi.org/10.1097/OLQ.0000000000000964DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6426356PMC
April 2019
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Standards for Treatment and Control Regimens in Therapeutic Trials for Gonorrhea: Lessons From a "Failed" Trial.

Sex Transm Dis 2019 May;46(5):287-289

Division of Infectious Diseases, Department of Medicine, Johns Hopkins Bayview Medical Center, Baltimore, MD.

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http://dx.doi.org/10.1097/OLQ.0000000000000994DOI Listing

The resurgence of syphilis in high-income countries in the 2000s: a focus on Europe.

Epidemiol Infect 2019 Jan;147:e143

European Centre for Disease Prevention and Control,Stockholm,Sweden.

Syphilis can cause severe complications and sequelae. Following a decrease in reported cases in European Union/European Economic Area (EU/EEA) and other high-income countries in the 1980s and 1990s as a result of the HIV epidemic and ensuing changes in sexual behaviour, trends started to increase in the 2000s in a number of EU/EEA Member States with higher rates among men and a large proportion of cases reported among men who have sex with men (MSM), particularly HIV-positive MSM. Trends in EU/EEA Member States vary however with some countries continuing to report decreases in the number of reported cases (mostly in the Eastern part of EU/EEA) whereas many Western European countries report increasing numbers of cases. Read More

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http://dx.doi.org/10.1017/S0950268819000281DOI Listing
January 2019
1 Read