19,744 results match your criteria Gonorrhea

Increasing incidence rates of sexually transmitted infections from 2010 to 2019: an analysis of temporal trends by geographical regions and age groups from the 2019 Global Burden of Disease Study.

BMC Infect Dis 2022 Jun 26;22(1):574. Epub 2022 Jun 26.

Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China.

Background: World Health Organization announced its goal of ending sexually transmitted infection (STI) epidemics by 2030. To provide a reference for tailored prevention strategies, we analyzed trends and differences in STIs by geographical regions and age groups from 1990 to 2019.

Methods: Annual number of new infections and age-standardized incidence rates (ASRs) of syphilis, chlamydia, gonorrhea, trichomoniasis, and genital herpes were recorded from the 2019 Global Burden of Disease study. Read More

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We need estimates of gonorrhoea vaccine protection and symptomaticity by sex and anatomical site.

Lancet Infect Dis 2022 Jul;22(7):937

Medical Research Council Centre for Global Infectious Disease Analysis and National Institute for Health and Care Research Health Protection Research Unit in Modelling and Health Economics, Imperial College London, London W2 1PG, UK.

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Antimicrobial Susceptibility Testing Patterns of from Patients Attending Sexually Transmitted Infections Clinics in Six Regions in Tanzania.

Trop Med Infect Dis 2022 Jun 2;7(6). Epub 2022 Jun 2.

National Institute for Medical Research, Mwanza Research Centre, Mwanza P.O. Box 1462, Tanzania.

Antimicrobial resistance (AMR) is global health threat that is on the increase, and it has been adversely affecting the proper management of sexually transmitted infections (STI). Data on antimicrobial susceptibility testing patterns of are limited in local settings. We determined in vitro antimicrobial susceptibility and phenotypic profiles of isolated from STI/Outpatient Department (OPD) clinics. Read More

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Sexual behavior and drug use impact in gay, bisexual, and other men who have sex with men.

Med Clin (Barc) 2022 Jun 17. Epub 2022 Jun 17.

Infectious Diseases Department, Hospital Universitari Vall d'Hebron, Barcelona, Spain; Infectious Diseases Research Group, Vall d'Hebron Institut de Recerca (VHIR), Barcelona, Spain; Medicine Department, Universitat Autònoma de Barcelona, Barcelona, Spain.

Background: The emergence of chemsex has raised several concerns about gay, bisexual, and other men who have sex with men's (GBMSM) health. In this study we aim to analyze illicit drugs and chemsex use, sexual behavior and sexually transmitted infections (STI) in GBMSM who attended to a sexual health clinic and to explore any potential association between drug use and STI.

Methods: We conducted an observational study between January and June 2019 among GBMSM population attending to a STI clinic in Barcelona, Spain. Read More

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Facilitators and barriers to point-of-care testing for sexually transmitted infections in low- and middle-income countries: a scoping review.

BMC Infect Dis 2022 Jun 20;22(1):561. Epub 2022 Jun 20.

Department of Global Health and Infection, Brighton and Sussex Medical School, Brighton, UK.

Background: Sexually transmitted infections (STIs) in low- and middle-income countries (LMICs) are predominantly managed by syndromic management. However, most STIs are asymptomatic. These untreated STIs cause individual morbidity, and lead to high STI prevalences. Read More

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Preconception reproductive tract infections status and adverse pregnancy outcomes: a population-based retrospective cohort study.

BMC Pregnancy Childbirth 2022 Jun 20;22(1):501. Epub 2022 Jun 20.

NHC Key Lab. of Reproduction Regulation, Shanghai Institute for Biomedical and Pharmaceutical Technologies, Fudan University, 400020, Shanghai, China.

Background: Reproductive tract infections can cause serious adverse outcomes for pregnant women such as spontaneous abortion and preterm birth. However, it is unclear whether maternal reproductive tract infection before pregnancy would also be related to any adverse pregnancy outcomes. This study aims to investigate the association of maternal preconception reproductive tract infections with subsequent adverse pregnancy outcomes. Read More

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Sexually Transmitted Infection Testing, Prevalence, and Treatment among Individuals Receiving HIV Pre-Exposure Prophylaxis within an Integrated Healthcare Delivery System.

Sex Transm Dis 2022 Jun 17. Epub 2022 Jun 17.

Centers for Disease Control and Prevention, Atlanta, GA.

Background: Initial and follow-up sexually transmitted infection (STI) and HIV testing is recommended when taking HIV preexposure prophylaxis (PrEP). We assessed STI services before and after PrEP initiation among persons aged ≥18 years.

Methods: We conducted this retrospective cohort study at an US integrated healthcare delivery system. Read More

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Extensively drug-resistant (XDR) causing possible gonorrhoea treatment failure with ceftriaxone plus azithromycin in Austria, April 2022.

Euro Surveill 2022 Jun;27(24)

Institute for Global Health, University College London, London, United Kingdom.

We describe a gonorrhoea case with ceftriaxone plus high-level azithromycin resistance. In April 2022, an Austrian heterosexual male was diagnosed with gonorrhoea after sexual intercourse with a female sex worker in Cambodia. Recommended treatment with ceftriaxone (1 g) plus azithromycin (1. Read More

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Patterns of Sexually Transmitted Co-infections and Associated Factors Among Men Who Have Sex With Men: A Cross-Sectional Study in Shenyang, China.

Front Public Health 2022 31;10:842644. Epub 2022 May 31.

National Health Commission Key Laboratory of AIDS Immunology, National Clinical Research Center for Laboratory Medicine, The First Affiliated Hospital of China Medical University, Shenyang, China.

Background: Men who have sex with men (MSM) are disproportionately affected by sexually transmitted infections (STIs). We sought to describe patterns of sexually transmitted co-infections and explore factors associated with increased acquisition of STIs among MSM.

Methods: We enrolled MSM in Shenyang, China, between July and December 2020 to test for four STIs, including human papillomavirus (HPV), (CT), (NG), and (TP). Read More

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Performance of the first commercial dual resistance assay, AmpliSens -ML/FQ-Resist-FL, for detection of potential macrolide and quinolone resistance-associated mutations and prevalence of resistance mutations in St. Petersburg, Russia.

Sex Transm Infect 2022 Jun 16. Epub 2022 Jun 16.

WHO Collaborating Centre for Gonorrhoea and Other STIs, Department of Laboratory Medicine, Orebro universitet, Orebro, Sweden

Objectives: Antimicrobial resistance in (MG) is a poorly surveyed and controlled global health concern. We evaluated the first commercial dual resistance assay, AmpliSens -ML/FQ-Resist-FL assay, for detection of potential macrolide and quinolone resistance-associated mutations (MRAMs and QRAMs, respectively) and estimated the prevalence of these mutations in MG in St. Petersburg, Russia. Read More

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Doxycycline post-exposure prophylaxis for prevention of sexually transmitted infections among Kenyan women using HIV pre-exposure prophylaxis: study protocol for an open-label randomized trial.

Trials 2022 Jun 16;23(1):495. Epub 2022 Jun 16.

Department of Global Health, University of Washington, Box 359931, 325 Ninth Ave, WA, 98104, Seattle, USA.

Background: Women in Africa face disproportionate risk of human immunodeficiency virus (HIV) acquisition, accounting for more than half of new infections in Africa and similarly face a disproportionate burden of sexually transmitted infections (STIs). Very high STI prevalence is being observed globally, especially among people taking pre-exposure prophylaxis (PrEP) for HIV prevention. Doxycycline post-exposure prophylaxis (dPEP) has been proposed as an STI prevention strategy to reduce chlamydia, syphilis, and possibly gonorrhea, and trials are ongoing among cisgender men who have sex with men (MSM) and transgender women who are taking PrEP in high-income settings. Read More

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Prevalence of active trachoma and its associated factors among 1-9 years of age children from model and non-model kebeles in Dangila district, northwest Ethiopia.

PLoS One 2022 15;17(6):e0268441. Epub 2022 Jun 15.

Department of Public Health, College of Health Sciences, Debre Markos University, Debre Markos, Ethiopia.

Background: Trachoma is the leading infectious disease that leads to blindness worldwide, especially in developing countries. Though Ethiopia had targeted a trachoma elimination program by 2020, the problem worsens, particularly in the Amhara Region. Even though sustained intervention measures are undertaken across the region, it is unclear why trachoma is still a significant public health problem. Read More

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Genetic characteristics of azithromycin-resistant collected in Hyogo, Japan during 2015-2019.

J Med Microbiol 2022 Jun;71(6)

Department of Urology, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe, 650-0017, Japan.

Azithromycin (AZM) is a therapeutic drug for sexually transmitted infections and is used for when first- and second-line drugs are not available. Recently, the susceptibility of against AZM has been decreasing worldwide. Azithromycin-resistance (AZM-R) rates among in Japan are increasing, and the gene mutations and epidemiological characteristics of AZM-R in have not been fully investigated. Read More

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Tailoring a sexual health curriculum to the sexual health challenges seen by midwifery, nursing and medical providers and students in Tanzania.

Afr J Prim Health Care Fam Med 2022 May 31;14(1):e1-e9. Epub 2022 May 31.

Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, United States of America.

Background:  Tanzania is a country experiencing multiple sexual health challenges, but providers receive no formal training in sexual health.

Aim:  This study aimed to assess (1) what sexual health challenges are commonly seen in clinics in Tanzania, (2) which are raised by patients, (3) which are not addressed and (4) which topics to prioritise for a sexual health curriculum.

Setting:  Healthcare settings in Tanzania. Read More

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Rifampicin Resistance Associated with Mutations in Neisseria gonorrhoeae Clinical Strains Isolated in Austria, 2016 to 2020.

Microbiol Spectr 2022 Jun 9:e0275721. Epub 2022 Jun 9.

Institute for Medical Microbiology and Hygiene, Austrian Agency for Health and Food Safetygrid.414107.7, Vienna, Austria.

Due to increasing rates of antimicrobial resistance (AMR) in Neisseria gonorrhoeae, alternative treatments should be considered. To assess rifampicin's potential as a gonorrhea treatment, we used mutations to estimate rifampicin resistance in Austrian N. gonorrhoeae isolates. Read More

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Gynecologic care utilization in asylum-seeking women in New York City.

J Migr Health 2022 29;6:100116. Epub 2022 May 29.

Libertas Center, Elmhurst Hospital, 79-01 Broadway, Queens, NY, USA.

Introduction: Over 25,000 individuals are granted asylum status in the United States annually. Gender-based violence (GBV) has historically been supported as a claim for persecution to apply for asylum. In women, GBV is a known risk factor for sexually transmitted infections, poor mental health, and worse perinatal outcomes. Read More

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Systematic Review and Meta-Analysis to Estimate the Treatment Effect and Inform a Non-Inferiority Margin for a Phase 3 Non-Inferiority Trial in Uncomplicated Urogenital Gonorrhea.

Sex Transm Dis 2022 Jun 8. Epub 2022 Jun 8.

GlaxoSmithKline plc., Orchard Park, New York, USA.

Background: Active-controlled non-inferiority studies are used to investigate novel agents for uncomplicated urogenital gonorrhea (uUGC) as placebo-controlled trials are unethical. A systematic literature review and meta-analysis were conducted to estimate the ceftriaxone and proxy-for-placebo microbiological treatment effect and determine an appropriate non-inferiority margin for phase 3 trials.

Methods: Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines were followed. Read More

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Development of a psychometric tool to measure community solidarity among sexual minorities: Evidence from a pay-it-forward randomized controlled trial.

Sex Transm Dis 2022 Jun 8. Epub 2022 Jun 8.

University of Connecticut School of Medicine, Farmington, CT, USA.

Background: Community solidarity is increasingly important in public health. However, few studies have examined solidarity in relation to health outcomes. The purpose of this study was to develop a psychometric tool to measure solidarity among Chinese men-who-have-sex-with-men (MSM) and assess whether community solidarity relates to differences in STI testing. Read More

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Significant increase in azithromycin "resistance" and susceptibility to ceftriaxone and cefixime in Neisseria gonorrhoeae isolates in 26 European countries, 2019.

BMC Infect Dis 2022 Jun 7;22(1):524. Epub 2022 Jun 7.

UK Health Security Agency, London, UK.

Background: The European Gonococcal Antimicrobial Surveillance Programme (Euro-GASP) performs annual sentinel surveillance of Neisseria gonorrhoeae susceptibility to therapeutically relevant antimicrobials across the European Union/European Economic Area (EU/EEA). We present the Euro-GASP results from 2019 (26 countries), linked to patient epidemiological data, and compared with data from previous years.

Methods: Agar dilution and minimum inhibitory concentration (MIC) gradient strip methodologies were used to determine the antimicrobial susceptibility (using EUCAST clinical breakpoints, where available) of 3239 N. Read More

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The ethnomedicinal and functional uses, phytochemical and pharmacology of compounds from Ardisia species: An updated review.

Med Res Rev 2022 Jun 6. Epub 2022 Jun 6.

Department of Pharmaceutical Sciences, St. John's University, New York City, New York, USA.

Medicinal plants are considered to be a critical source of novel compounds and pharmacophores. The genus Ardisia, consisting of approximately 500 species, is the largest genus in the Myrsinaceae family. Ardisia species are widely distributed throughout tropical and subtropical regions of the world and have been used for the treatment of cancer, hypertension, irregular menstruation, gonorrhea, diarrhea and postnatal syndromes, among others. Read More

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Prevalence and Incidence of Sexually Transmitted Infection in Injectable Progestin Contraception Users in South Africa.

Front Reprod Health 2021 Jul 16;3. Epub 2021 Jul 16.

University of Zimbabwe Clinical Trials Research Centre, Department of Obstetrics and Gynaecology, Harare, Zimbabwe.

Introduction: Whether intramuscular depot medroxyprogesterone acetate (DMPA-IM) and norethisterone enanthate (NET-EN) have a differential impact on the incidence of sexually transmitted infection (STI) remains unclear. In the Vaginal and Oral Interventions to Control the Epidemic (VOICE) trial, HIV-1 acquisition was higher for DMPA-IM users vs. NET-EN users. Read More

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Europe-wide expansion and eradication of multidrug-resistant Neisseria gonorrhoeae lineages: a genomic surveillance study.

Lancet Microbe 2022 Jun 10;3(6):e452-e463. Epub 2022 May 10.

WHO Collaborating Centre for Gonorrhoea and Other Sexually Transmitted Infections, Department of Laboratory Medicine, Faculty of Medicine and Health, Örebro University, Örebro, Sweden; Institute for Global Health, University College London, London, UK. Electronic address:

Background: Genomic surveillance using quality-assured whole-genome sequencing (WGS) together with epidemiological and antimicrobial resistance (AMR) data is essential to characterise the circulating Neisseria gonorrhoeae lineages and their association to patient groups (defined by demographic and epidemiological factors). In 2013, the European gonococcal population was characterised genomically for the first time. We describe the European gonococcal population in 2018 and identify emerging or vanishing lineages associated with AMR and epidemiological characteristics of patients, to elucidate recent changes in AMR and gonorrhoea epidemiology in Europe. Read More

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Impact of COVID-19 pandemic on the epidemiology of STDs in China: based on the GM (1,1) model.

BMC Infect Dis 2022 Jun 4;22(1):519. Epub 2022 Jun 4.

Shanghai Skin Disease Clinical College of Anhui Medical University, Shanghai Skin Disease Hospital, Shanghai, 200050, People's Republic of China.

Background: COVID-19 and Sexually Transmitted Diseases (STDs) are two very important diseases. However, relevant researches about how COVID-19 pandemic has impacted on the epidemiological trend of STDs are limited in China. This study aimed to analyze the impact of COVID-19 on STDs in China and proposed relevant recommendations to be used in bettering health. Read More

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Three-site screening for STIs in men who have sex with men using online self-testing in an English sexual health service.

Sex Transm Infect 2022 Jun 2. Epub 2022 Jun 2.

Department of Psychology, University of Southampton, Southampton, UK

Objectives: Among men who have sex with men (MSM) in the UK, (CT) and (NG) infections commonly occur asymptomatically at extragenital sites. Therefore, MSM seeking sexual health services are offered three-site (oropharyngeal, rectal and urogenital) STI screening. To increase access to screening, some UK sexual health services enable asymptomatic service users to order free STI screening kits online for self-sampling at home. Read More

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Comparing adverse neonatal and maternal outcomes of chlamydia, gonorrhoea, and syphilis infections and co-infections in pregnancy.

Paediatr Perinat Epidemiol 2022 May 29. Epub 2022 May 29.

Department of Medicine, University of Calgary, Calgary, Alberta, Canada.

Background: While maternal sexually transmitted infections (STIs) during pregnancy have been extensively studied, fewer studies have directly compared the associations of different infections and co-infections or investigated the association between STIs in pregnancy and maternal outcomes.

Objectives: We examine associations between STIs and co-infections in pregnancy on risks of adverse neonatal and maternal outcomes.

Methods: Data from the 2019 US natality files (n = 3,747,882) were used to assess the associations between STIs in pregnancy on adverse pregnancy outcomes. Read More

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Real-world trends in incidence of bacterial sexually transmissible infections among gay and bisexual men using HIV pre-exposure prophylaxis (PrEP) in Australia following nationwide PrEP implementation: an analysis of sentinel surveillance data.

Lancet Infect Dis 2022 May 25. Epub 2022 May 25.

Burnet Institute, Melbourne, VIC, Australia; School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia.

Background: Although data from large implementation trials suggest that sexually transmissible infection (STI) risk increases among gay and bisexual men who initiate HIV pre-exposure prophylaxis (PrEP), there are few data on the trends in population-level STI incidence in the years following widespread PrEP implementation. We aimed to describe trends in bacterial STI incidence among gay and bisexual men using PrEP across Australia in the context of broad PrEP availability through Australia's subsidised medicines scheme.

Methods: We analysed linked clinical data from HIV-negative gay and bisexual men aged 16 years or older who had been prescribed PrEP across a sentinel surveillance clinical network, including 37 clinics in Australia, between Jan 1, 2016, and Dec 31, 2019. Read More

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Prevention of Neisseria gonorrhoeae with meningococcal B vaccine: a matched cohort study in Southern California.

Clin Infect Dis 2022 Jun 1. Epub 2022 Jun 1.

Department of Research & Evaluation, Kaiser Permanente Southern California, Pasadena, CA, USA.

Background: Neisseria gonorrhoeae is acquiring increasing resistance to available oral antibiotics, and current screening and treatment approaches have not decreased gonorrhea incidence. Although a gonorrhea-specific vaccine does not exist, N. gonorrhoeae shares much of its genome with Neisseria meningitidis, notably critical antigenic determinants including outer membrane vesicles (OMV). Read More

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Pediatric Emergency Department Testing for Gonorrhea and Chlamydia in Children.

Pediatr Emerg Care 2022 Jun 21;38(6):247-252. Epub 2022 Feb 21.

From the Department of Pediatrics, Ann & Robert H. Lurie Children's Hospital.

Objective: This study aimed to describe trends in the utilization of nucleic acid amplification (NAAT) testing for gonorrhea and chlamydia in US pediatric emergency departments. Nucleic acid amplification has been recommended over genital culture by the American Academy of Pediatrics and Centers for Disease Control and Prevention for children evaluated for sexual abuse.

Methods: We conducted a multicenter study of children aged 12 months to 11 years tested for gonorrhea and chlamydia between 2004 and 2018 at 22 hospitals in the Pediatric Health Information System. Read More

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