18,192 results match your criteria Gonorrhea


[Ancient and modern plagues: Sexual transmitted diseases (STD)].

MMW Fortschr Med 2019 Feb;161(3):44-47

Klinik und Poliklinik für Innere Medizin II, Klinikum rechts der Isar, Ismaninger Str. 22, D-81675, München, Deutschland.

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http://dx.doi.org/10.1007/s15006-019-0185-5DOI Listing
February 2019

In vitro activity of the novel oral antimicrobial SMT-571, with a new mechanism of action, against MDR and XDR Neisseria gonorrhoeae: future treatment option for gonorrhoea?

J Antimicrob Chemother 2019 Feb 18. Epub 2019 Feb 18.

WHO Collaborating Centre for Gonorrhoea and Other Sexually Transmitted Infections, National Reference Laboratory for Sexually Transmitted Infections, Department of Laboratory Medicine, Faculty of Medicine and Health, Örebro University, Örebro, Sweden.

Background: Lack of effective treatment of gonorrhoea due to increasing antimicrobial resistance in Neisseria gonorrhoeae is a serious threat to the management and control of the infection. Novel antimicrobials are required to prevent the infection becoming untreatable.

Objectives: Herein, we investigated the in vitro activity of a novel small-molecule antimicrobial with a new mechanism of action, SMT-571, against a large collection of clinical N. Read More

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http://dx.doi.org/10.1093/jac/dkz060DOI Listing
February 2019

Risk of ectopic pregnancy and tubal infertility following gonorrhoea and chlamydia infections.

Clin Infect Dis 2019 Feb 18. Epub 2019 Feb 18.

University of New South Wales, Sydney, Australia.

Gonorrhoea and chlamydia are important causes of pelvic inflammatory disease. Chlamydia also causes long-term sequelae, but the role of gonorrhoea is unclear. We followed 300,000 reproductive-aged women for 10 years for ectopic pregnancy and tubal infertility; our findings suggest that both infections confer similar increases in risk of these outcomes. Read More

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http://dx.doi.org/10.1093/cid/ciz145DOI Listing
February 2019

Modelling the in-host dynamics of Neisseria gonorrhoeae infection.

Pathog Dis 2019 Feb 16. Epub 2019 Feb 16.

School of Public Health and Community Medicine, UNSW Sydney, NSW 2052, Australia.

The bacterial species Neisseria gonorrhoeae (NG) has evolved to replicate effectively and exclusively in human epithelia, with its survival dependent on complex interactions between bacteria, host cells and antimicrobial agents. A better understanding of these interactions is needed to inform development of new approaches to gonorrhoea treatment and prevention but empirical studies have proven difficult, suggesting a role for mathematical modelling. Here we describe an in-host model of progression of untreated male symptomatic urethral infection, including NG growth and interactions with epithelial cells and neutrophils, informed by in vivo and in vitro studies. Read More

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http://dx.doi.org/10.1093/femspd/ftz008DOI Listing
February 2019

Trichomonas vaginalis virus (TVV) among women with trichomoniasis and associations with demographics, clinical outcomes, and metronidazole resistance.

Clin Infect Dis 2019 Feb 15. Epub 2019 Feb 15.

Division of Infectious Diseases, University of Alabama at Birmingham.

Background: Trichomonas vaginalis virus (TVV) is a non-segmented, 4.5-5.5 kbp, double-stranded RNA virus infecting T. Read More

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http://dx.doi.org/10.1093/cid/ciz146DOI Listing
February 2019

Does Male Circumcision Reduce Women's Risk of Sexually Transmitted Infections, Cervical Cancer, and Associated Conditions?

Front Public Health 2019 31;7. Epub 2019 Jan 31.

Department of Urology, University of Washington School of Medicine, Seattle, WA, United States.

Male circumcision (MC) is proven to substantially reduce men's risk of a number of sexually transmitted infections (STIs). We conducted a detailed systematic review of the scientific literature to determine the relationship between MC and risk of STIs and associated conditions in women. Database searches by "circumcision women" and "circumcision female" identified 68 relevant articles for inclusion. Read More

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http://dx.doi.org/10.3389/fpubh.2019.00004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365441PMC
January 2019
1 Read

Rigour after gonorrhea treatment in a 55-year-old man.

Authors:
Patrick O'Byrne

Can Fam Physician 2019 Feb;65(2):112-115

Associate Professor in the School of Nursing at the University of Ottawa in Ontario and a nurse practitioner at the Sexual Health Clinic in Ottawa.

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February 2019

Is fosfomycin a good alternative drug for gonorrhoea treatment in our setting?

Enferm Infecc Microbiol Clin 2019 Feb 11. Epub 2019 Feb 11.

Consorci del Laboratori Intercomarcal de l'Alt Penedès, l'Anoia i el Garraf,, Vilafranca del Penedès, Barcelona, España.

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http://dx.doi.org/10.1016/j.eimc.2018.12.010DOI Listing
February 2019

An evaluation of sexually transmitted infection and odds of preterm or early term birth using propensity score matching.

Sex Transm Dis 2019 Feb 11. Epub 2019 Feb 11.

California Preterm Birth Initiative, University of California San Francisco, San Francisco, California, USA.

Background: Few studies have examined the relationship between sexually transmitted infections (STIs) and preterm birth (<37 weeks gestation) by subtype (<32 weeks, 32 - 36 weeks, spontaneous, provider-initiated). Here, we evaluate the odds of preterm (by subtype) and early term (37 and 38 weeks gestation) birth in women with an STI compared to a propensity score matched reference population.

Methods: The sample was selected from California births in 2007-2012. Read More

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http://dx.doi.org/10.1097/OLQ.0000000000000985DOI Listing
February 2019
2 Reads

Cross-sectional analysis of chemsex drug use and gonorrhoea diagnosis among men who have sex with men in the UK.

Sex Health 2019 Feb 14. Epub 2019 Feb 14.

Illicit drug use among men who have sex with men (MSM) has been associated with sexual risk and HIV. Less is documented about associations with other sexually transmissible infections (STIs). The aim of the present study was to determine whether the use of drugs commonly associated with chemsex is associated with increased risk of gonorrhoea among MSM. Read More

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http://dx.doi.org/10.1071/SH18159DOI Listing
February 2019

Mechanistic and Structural Basis for the Actions of the Antibacterial Gepotidacin against Staphylococcus aureus Gyrase.

ACS Infect Dis 2019 Feb 13. Epub 2019 Feb 13.

Gepotidacin is a first-in-class triazaacenaphthylene novel bacterial topoisomerase inhibitor (NBTI). The compound has successfully completed phase II trials for the treatment of acute bacterial skin/skin structure infections and for the treatment of uncomplicated urogenital gonorrhea. It also displays robust in vitro activity against a range of wild-type and fluoroquinolone-resistant bacteria. Read More

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http://dx.doi.org/10.1021/acsinfecdis.8b00315DOI Listing
February 2019

Presumptive and Follow-up Treatment for Gonorrhea and Chlamydia Among Patients Attending Public Health Department Clinics in Virginia, 2016.

Sex Transm Dis 2019 Mar;46(3):199-205

Background: Presumptive antibiotic treatment is common for suspected chlamydia (CT) and gonorrhea (GC) infections before laboratory confirmation to prevent complications, reduce loss-to-follow-up, and interrupt transmission. We assessed this practice in sexually transmitted disease (STD) and family planning clinics.

Methods: We performed a retrospective analysis of data from clinics in Virginia in 2016 using administrative data merged with electronic laboratory reporting data. Read More

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http://dx.doi.org/10.1097/OLQ.0000000000000922DOI Listing
March 2019
1 Read

Burgeoning Irrational Antibiotics use in Primary Health Care in Nepal.

J Nepal Health Res Counc 2019 Jan 28;16(41):473-475. Epub 2019 Jan 28.

Department of Clinical Pharmacology, Institute of Medicine, Tribhuvan University, Kathmandu, Nepal.

Rational use of drugs has immense impact on quality health care. Developing nations have 80% essential drug list prescription. Even though WHO estimates 15-25% antibiotics prescription in these regions, majority of Nepalese patients are prescribed more than one antibiotic in addition to inappropriate prescription in 10%-42% patients. Read More

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January 2019

Investigation of Safety Profile of Four Species and of Kaurenoic Acid by /Microsome Test.

Evid Based Complement Alternat Med 2019 10;2019:7631531. Epub 2019 Jan 10.

Laboratory of Research in Applied Microbiology (LAPEMA), University of Franca, Avenida Dr. Armando Salles de Oliveira 201, 14404-600 Franca, SP, Brazil.

Trees of the genus are native to the tropical regions of Latin America and Western Africa. sp is widely used as a popular medicine and it has various ethnopharmacological indications, including gonorrhea, bronchitis, asthma, skin ulcers, ulcers, sore throat, uterine infections, general inflammations, cancer, and leishmanioses. Kaurenoic acid is a naturally occurring diterpene found in and has been used as an anti-inflammatory, treatment of ulcer, leishmaniasis, and cancer. Read More

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http://dx.doi.org/10.1155/2019/7631531DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348810PMC
January 2019
1 Read

Typing and antimicrobial susceptibility of 134 Neisseria gonorrhoeae strains from Southern Spain.

Rev Esp Quimioter 2019 Feb 4. Epub 2019 Feb 4.

Fernando Cobo, Department of Microbiology and Instituto Biosanitario de Granada. University Hospital Virgen de las Nieves, Avda Fuerzas Armadas, 2 - 18014 Granada, Spain.

Objective: Last guidelines have recommended the introduction of dual antimicrobial therapy in order to avoid treatment failure. In the present report, the susceptibility to some antibiotics was evaluated, and the typing of Neisseria gonorrhoeae strains was performed.

Methods: Gonococcal isolates were tested for susceptibility according to the recommendations of both CLSI and EUCAST. Read More

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February 2019

A multisite implementation of a real-time polymerase chain reaction assay to predict ciprofloxacin susceptibility in Neisseria gonorrhoeae.

Diagn Microbiol Infect Dis 2019 Jan 14. Epub 2019 Jan 14.

UCLA Division of Infectious Diseases, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.

There are no commercially available Food and Drug Administration-cleared rapid tests for Neisseria gonorrhoeae antimicrobial susceptibility testing. This study evaluated the performance of a laboratory-developed real-time polymerase chain reaction assay for genotyping the gyrA gene to determine antimicrobial susceptibility to ciprofloxacin. Validation and clinical performance of the gyrA assay were evaluated across 3 geographic locations (Los Angeles, San Francisco, Philadelphia). Read More

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http://dx.doi.org/10.1016/j.diagmicrobio.2018.12.018DOI Listing
January 2019

Bacterial sexually transmitted infections in France: recent trends and patients' characteristics in 2016.

Euro Surveill 2019 Jan;24(5)

Santé publique France (the French national public health agency), Saint-Maurice, France.

Diagnoses of bacterial sexually transmitted infections (STI) have been increasing in France since their resurgence in the late 1990s. This article presents recent epidemiological trends until 2016 and the patients' characteristics. STI surveillance relies on sentinel networks: a clinician-based network RésIST (clinical, biological and behavioural data for early syphilis and gonorrhoea), the lymphogranuloma venereum (LGV) network (clinical, biological and behavioural data for rectal LGV, and the laboratory networks Rénachla and Rénago (demographic and biological data for chlamydial infections and gonorrhoea, respectively). Read More

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http://dx.doi.org/10.2807/1560-7917.ES.2019.24.5.1800038DOI Listing
January 2019
3 Reads

Quantitation of all Four Gardnerella vaginalis Clades Detects Abnormal Vaginal Microbiota Characteristic of Bacterial Vaginosis More Accurately than Putative G. vaginalis Sialidase A Gene Count.

Mol Diagn Ther 2019 Feb;23(1):139-147

WHO Collaborating Centre for Gonorrhoea and other STIs, Department of Laboratory Medicine, Microbiology, Örebro University Hospital, Södra Grevrosengatan 2, 701 85, Örebro, Sweden.

Background: Bacterial vaginosis (BV) is a vaginal disorder characterized by a depletion of the normal lactobacillus-dominant microbiota and overgrowth of mainly anaerobic bacteria.

Objectives: The study aimed to evaluate the distribution and abundance of the Gardnerella vaginalis clades and sialidase A gene in vaginal samples from Russian women, and investigate if the G. vaginalis sialidase A gene count detects an abnormal vaginal microbiota characteristic of BV more accurately than G. Read More

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http://dx.doi.org/10.1007/s40291-019-00382-5DOI Listing
February 2019
2 Reads

Correlations between HIV infection and rectal gonorrhea incidence in men who have sex with men: Implications for future HIV pre-exposure prophylaxis trials.

J Infect Dis 2019 Jan 31. Epub 2019 Jan 31.

Deputy Director, Division of Antiviral Products Office of Antimicrobial Products, Office of New Drugs Center for Drug Evaluation and Research U.S. Food and Drug Administration 10903 New Hampshire Avenue Building 22, Room 6370, Silver Spring MD.

Using published data, we found a direct correlation between the incidence of rectal gonorrhea and HIV infection in MSM who were not using oral pre-exposure prophylaxis. HIV incidence was predicted using rectal gonorrhea incidence as the determinant in regression analysis. The observed correlations suggest the rectal gonorrhea incidence can potentially serve as a predictor of HIV incidence. Read More

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https://academic.oup.com/jid/advance-article/doi/10.1093/inf
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http://dx.doi.org/10.1093/infdis/jiz037DOI Listing
January 2019
5 Reads

Screening for Sexually Transmitted Diseases.

Prim Care 2019 Mar 24;46(1):157-173. Epub 2018 Dec 24.

Residency in General Preventive Medicine and Public Health, Florida Department of Health, Palm Beach County, 800 Clematis, West Palm Beach, FL 33401, USA.

This article discusses sexually transmitted infections (STI) screening and focuses on reportable STIs. This includes gonorrhea, chlamydia, syphilis, and human immunodeficiency virus. Hepatitis B and C, trichomonas, and herpes are covered as well. Read More

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http://dx.doi.org/10.1016/j.pop.2018.10.013DOI Listing
March 2019
4 Reads

[Sexually Transmitted Infections - What's New, What's Different?]

Dtsch Med Wochenschr 2019 Feb 31;144(3):165-170. Epub 2019 Jan 31.

Abteilung Infektiologie, Klinik für Innere Medizin II, Universitätsklinikum Freiburg.

The incidence of sexually transmitted infections like syphilis or gonorrhea is still rising, particularly in the high-risk population of men having sex with men (MSM). Neisseria gonorrhoeae is capable to develop resistance to all antibiotics previously or currently used for treatment. Dual antimicrobial therapy with ceftriaxone and azithromycin is considered the current empirical first-line therapy. Read More

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http://dx.doi.org/10.1055/a-0655-6657DOI Listing
February 2019
4 Reads

Using genomics to understand antimicrobial resistance and transmission in Neisseria gonorrhoeae.

Microb Genom 2019 Jan 30. Epub 2019 Jan 30.

Infection Genomics, Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridgeshire, UK.

Gonorrhoea infections are on the increase and strains that are resistant to all antimicrobials used to treat the disease have been found worldwide. These observations encouraged the World Health Organization to include Neisseria gonorrhoeae on their list of high-priority organisms in need of new treatments. Fortunately, concurrent resistance to both antimicrobials used in dual therapy is still rare. Read More

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http://dx.doi.org/10.1099/mgen.0.000239DOI Listing
January 2019

Evolution of the exclusively human pathogen : Human-specific engagement of immunoregulatory Siglecs.

Evol Appl 2019 Feb 3;12(2):337-349. Epub 2019 Jan 3.

Glycobiology Research and Training Center University of California, San Diego La Jolla California.

causes the sexually transmitted disease gonorrhea exclusively in humans and uses multiple strategies to infect, including acquisition of host sialic acids that cap and mask lipooligosaccharide termini, while restricting complement activation. We hypothesized that gonococci selectively target human anti-inflammatory sialic acid-recognizing Siglec receptors on innate immune cells to blunt host responses and that pro-inflammatory Siglecs and pseudogene polymorphisms represent host evolutionary adaptations to counteract this interaction. can indeed engage multiple human but not chimpanzee CD33rSiglecs expressed on innate immune cells and in the genitourinary tract--including Siglec-11 (inhibitory) and Siglec-16 (activating), which we detected for the first time on human cervical epithelium. Read More

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http://dx.doi.org/10.1111/eva.12744DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346652PMC
February 2019
2 Reads

Novel Antibiotic Efficacious in Treating Gonorrhea.

Authors:
Anita Slomski

JAMA 2019 Jan;321(4):335

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http://dx.doi.org/10.1001/jama.2018.22029DOI Listing
January 2019

Extragenital chlamydia infection among active-duty women in the United States Navy.

Mil Med Res 2019 01 29;6(1). Epub 2019 Jan 29.

Division of Infectious Diseases, Naval Medical Center San Diego, 34800 Bob Wilson Drive, Ste 201, San Diego, CA, 92134, USA.

Background: Pharyngeal and anorectal reservoirs of gonorrhea (GC) and chlamydia (CT) are increasingly recognized among heterosexual women. While a number of studies performed at sexually transmitted disease (STD) clinics have found a high prevalence of extragenital GC/CT infection, such screening is typically not offered during routine primary care visits for women. We sought to define the prevalence of and factors associated with extragenital GC/CT among women in the U. Read More

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http://dx.doi.org/10.1186/s40779-019-0193-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350339PMC
January 2019
2 Reads

A Review on Blighia Sapida K.D. Koenig (syn. Cupania sapida Voigt.)'s: Its Economic Importance, Phytochemistry and Pharmacological Activity: Channeling these Claims for the Present and Future.

J Ethnopharmacol 2019 Jan 24. Epub 2019 Jan 24.

Dept. of Applied Chemistry, Federal University Dutsin-Ma, Katsina State, Nigeria; National Center for Natural Products Research, School of Pharmacy, The University of Mississippi, University, MS 38677, USA.

Ethnopharmacological Relevance: Ackee plant (Blighia sapida K. D. Koenig) (Sapindaceae) is used in Sub-Saharan African where it has its origin and in different parts of the world (The Caribbean, North and South America, Europe) traditionally to manage numerous ailments like backache, constipation, cancer, fever in young children, gonorrhea, dysentery, psychosis, hernia, stomach ache, malaria, rheumatism, typhoid and several others. Read More

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http://dx.doi.org/10.1016/j.jep.2019.01.017DOI Listing
January 2019
6 Reads

The Denominator problem: estimating the size of local populations of men-who-have-sex-with-men and rates of HIV and other STIs in Switzerland.

Sex Transm Infect 2019 Jan 24. Epub 2019 Jan 24.

Communicable Diseases Division, Swiss Federal Office of Public Health, Bern, Switzerland.

Objectives: There is no estimate of the current number of men who have sex with men (MSM) in Switzerland, or of their geographical distribution. We aimed to (1) estimate MSM concentration factors and population sizes for 83 Swiss postal code areas (PCA), including the nine largest Swiss cities, and (2) calculate MSM-specific local HIV prevalence and yearly rates of diagnosed HIV, hepatitis C virus (HCV), syphilis and gonorrhoea.

Methods: We triangulated data from general population estimates, MSM online surveys, published data on HIV prevalence and Swiss notification data for HIV and STDs. Read More

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http://sti.bmj.com/lookup/doi/10.1136/sextrans-2017-053363
Publisher Site
http://dx.doi.org/10.1136/sextrans-2017-053363DOI Listing
January 2019
3 Reads

Proportion of Incident HIV Cases among Men Who Have Sex with Men Attributable to Gonorrhea and Chlamydia: A Modeling Analysis.

Sex Transm Dis 2019 Jan 19. Epub 2019 Jan 19.

Department of Epidemiology, Emory University, Atlanta, Georgia.

Background: Sexually transmitted infections (STIs) are associated with an increased risk of HIV acquisition and transmission. We estimated the proportion of HIV incidence among men who have sex with men attributable to infection with the two most common bacterial STIs, Neisseria gonorrhoeae (NG) and Chlamydia trachomatis (CT).

Methods: We used a stochastic, agent-based model of a sexual network of MSM with co-circulating HIV, NG, and CT infections. Read More

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http://dx.doi.org/10.1097/OLQ.0000000000000980DOI Listing
January 2019
1 Read
2.842 Impact Factor

Efficacy and safety of single dose oral delafloxacin compared with intramuscular ceftriaxone for uncomplicated gonorrhea treatment: an open-label, non-inferiority, Phase 3, multicenter, randomized study.

Sex Transm Dis 2019 Jan 19. Epub 2019 Jan 19.

Melinta Therapeutics, Lincolnshire.

Background: We evaluated single oral dose delafloxacin versus single intramuscular (IM) ceftriaxone in participants with uncomplicated urogenital gonorrhea (primary objective). Secondary objectives included the efficacy, safety, and tolerability of delafloxacin versus ceftriaxone for uncomplicated urogenital, rectal, and/or pharyngeal gonorrhea.

Methods: In this open-label, multicenter study, 460 participants at 25 study centers were randomized (2:1) to receive a single 900mg oral dose of delafloxacin or 250mg IM ceftriaxone. Read More

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http://dx.doi.org/10.1097/OLQ.0000000000000971DOI Listing
January 2019
1 Read

Extragenital Gonorrhea and Chlamydia Among Men and Women According to Type of Sexual Exposure.

Sex Transm Dis 2019 Jan 19. Epub 2019 Jan 19.

Department of Biomedical & Health Informatics, University of Missouri-Kansas City School of Medicine, Kansas City, MO, USA.

Background: Current guidelines recommend screening for extragenital gonorrhea (GC) and chlamydia (CT) only among men having sex with men (MSM). Extragenital GC and CT is associated with treatment failure and disease transmission. The prevalence of exragenital GC/CT infections in women and in men having sex with women (MSW) are less well studied. Read More

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http://dx.doi.org/10.1097/OLQ.0000000000000967DOI Listing
January 2019
1 Read

Results from e-KISS: electronic-KIOSK Intervention for Safer Sex: A pilot randomized controlled trial of an interactive computer-based intervention for sexual health in adolescents and young adults.

PLoS One 2019 23;14(1):e0209064. Epub 2019 Jan 23.

Departments of Global Health and Medicine, University of Washington Schools of Medicine and Public Health; and Center for AIDS & STD, Seattle, WA, United States of America.

Introduction: Interactive computer-based interventions (ICBI) are potentially scalable tools for use in real-world settings to promote sexual health and prevent sexually transmitted infections (STIs) and unintended pregnancies. We developed and assessed the feasibility and acceptability of an ICBI for promoting adolescent and young adult sexual health, and the effectiveness of the intervention in reducing unprotected sex, STIs, and unintended pregnancy.

Methods: This pilot randomized controlled trial enrolled STI Clinic patients, in Seattle, Washington, who were 14-24 years old and reported unprotected vaginal sex during the last 2 months. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0209064PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343886PMC
January 2019
1 Read

The Reliability of Computerized Physician Order Entry Data for Research Studies.

Pediatr Emerg Care 2019 Jan 21. Epub 2019 Jan 21.

From the Division of Emergency Medicine and.

Objectives: In the United States, adolescents account for nearly half of the newly diagnosed sexually transmitted infections annually, and many of these infections are asymptomatic. Adolescents often seek care in pediatric emergency departments; thus, the emergency department is an important setting to implement adolescent sexually transmitted infection screening. Before implementation, baseline data reflecting current screening rates of symptomatic and asymptomatic patients were needed. Read More

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http://Insights.ovid.com/crossref?an=00006565-900000000-9825
Publisher Site
http://dx.doi.org/10.1097/PEC.0000000000001726DOI Listing
January 2019
5 Reads

Recommended screenings for chlamydia and gonorrhea: A Canadian guidelines review.

Authors:
Patrick OʼByrne

Nurse Pract 2019 Feb;44(2):35-41

Patrick O'Byrne is an associate professor and NP at the University of Ottawa School of Nursing in Ottawa, Ontario, Canada.

Chlamydia and gonorrhea are the most commonly diagnosed bacterial sexually transmitted infections (STIs), and both are increasing in incidence. Because these STIs are often asymptomatic and found at extragenital sites, such as the pharynx and rectum, it is important that clinicians know when and how to screen for them. This article reviews recent updates to Canadian screening guidelines, including the evidence that led to updates on this topic. Read More

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http://dx.doi.org/10.1097/01.NPR.0000552681.53898.05DOI Listing
February 2019
1 Read

Period of Measurement in Time-Series Predictions of Disease Counts from 2007 to 2017 in Northern Nevada: Analytics Experiment.

JMIR Public Health Surveill 2019 Jan 15;5(1):e11357. Epub 2019 Jan 15.

Center for Research and Education in Advanced Transportation Engineering Systems, Rowan University, Glassboro, NJ, United States.

Background: The literature in statistics presents methods by which autocorrelation can identify the best period of measurement to improve the performance of a time-series prediction. The period of measurement plays an important role in improving the performance of disease-count predictions. However, from the operational perspective in public health surveillance, there is a limitation to the length of the measurement period that can offer meaningful and valuable predictions. Read More

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http://dx.doi.org/10.2196/11357DOI Listing
January 2019
4 Reads

Evaluation of the performance of nucleic acid amplification tests (NAATs) in detection of chlamydia and gonorrhoea infection in vaginal specimens relative to patient infection status: a systematic review.

BMJ Open 2019 Jan 17;9(1):e022510. Epub 2019 Jan 17.

Department of Infectious Disease Epidemiology, Imperial College London, London, UK.

Objective: We evaluated the performance of nucleic acid amplification tests (NAATs) using vaginal specimens in comparison to specimens from the cervix or urine in their ability to detect chlamydia and gonorrhoea infection in women based on patient infection status (PIS).

Design: Systematic review.

Data Sources: EMBASE and Ovid MEDLINE databases were searched through 3 October 2017. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-022510DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340625PMC
January 2019
2 Reads

Impacts of Federal Prevention Funding on Reported Gonorrhea and Chlamydia Rates.

Am J Prev Med 2019 Mar 15;56(3):352-358. Epub 2019 Jan 15.

Division of STD Prevention, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia.

Introduction: The Centers for Disease Control and Prevention allocates funds annually to jurisdictions nationwide for sexually transmitted infection prevention activities. The objective of this study was to assess the effectiveness of federal sexually transmitted infection prevention funding for reducing rates of reported sexually transmitted infections.

Methods: In 2017-2018, finite distributed lag regression models were estimated to assess the impact of sexually transmitted infection prevention funding (in 2016 dollars per capita) on reported chlamydia rates from 2000 to 2016 and reported gonorrhea rates from 1981 to 2016. Read More

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http://dx.doi.org/10.1016/j.amepre.2018.09.012DOI Listing
March 2019
3 Reads

Pharmacokinetic considerations regarding the treatment of bacterial sexually transmitted infections with azithromycin: a review.

J Antimicrob Chemother 2019 Jan 11. Epub 2019 Jan 11.

Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, Australia.

Rates of bacterial sexually transmitted infections (STIs) continue to rise, demanding treatments to be highly effective. However, curing infections faces significant challenges due to antimicrobial resistance in Neisseria gonorrhoeae and Mycoplasma genitalium and especially treating STIs at extragenital sites, particularly rectal chlamydia and oropharyngeal gonorrhoea. As no new antimicrobials are entering the market, clinicians must optimize the currently available treatments, but robust data are lacking on how the properties or pharmacokinetics of antimicrobials can be used to inform STI treatment regimens to improve treatment outcomes. Read More

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https://academic.oup.com/jac/advance-article/doi/10.1093/jac
Publisher Site
http://dx.doi.org/10.1093/jac/dky548DOI Listing
January 2019
5 Reads

STD Partner Services to Monitor and Promote HIV Pre-Exposure Prophylaxis Use Among Men Who Have Sex with Men.

J Acquir Immune Defic Syndr 2019 Jan 8. Epub 2019 Jan 8.

Department of Medicine , University of Washington, Seattle, WA, US.

Background: Men who have sex with men (MSM) with bacterial STDs are at elevated risk for HIV. We evaluated the integration of pre-exposure prophylaxis (PrEP) referrals into STD partner services (PS) for MSM.

Setting: King County, Washington METHODS:: Disease Intervention Specialists (DIS) in King County attempt to provide PS to all MSM with early syphilis and, as resources allow, MSM with gonorrhea or chlamydia. Read More

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http://dx.doi.org/10.1097/QAI.0000000000001952DOI Listing
January 2019
1 Read

Commensal Bacteria: Not Just Innocent Bystanders.

MBio 2019 Jan 15;10(1). Epub 2019 Jan 15.

Department of Microbiology and Immunology, The University of Iowa, Carver College of Medicine, Iowa City, Iowa, USA

is quickly becoming untreatable due to its acquisition of resistance to multiple antimicrobials. It is vital that we begin to understand the mechanisms by which this is occurring. The paper by C. Read More

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http://dx.doi.org/10.1128/mBio.02723-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6336428PMC
January 2019

Trends in antimicrobial management of gonorrhoea by general practitioners in Amsterdam, the Netherlands, between 2010 and 2016: a cross-sectional study.

BMC Fam Pract 2019 Jan 15;20(1):12. Epub 2019 Jan 15.

Department of General Practice, Amsterdam University Medical Center, University of Amsterdam, Meibergdreef 9, P.O. Box 22700, 1100 DE, Amsterdam, The Netherlands.

Background: Sexually transmitted infections (STI) caused by multidrug resistant Neisseria gonorrhoea are an emerging threat to global health. In the Netherlands, the general practitioner (GP) provides the major part of STI care. In 2013 an update of the Dutch guideline was published, recommending a single dose of intramuscular ceftriaxone as treatment for gonorrhoea infections. Read More

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http://dx.doi.org/10.1186/s12875-018-0900-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332518PMC
January 2019
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Pharmacokinetic Data Are Predictive of Efficacy for Cefixime and Ceftriaxone against Susceptible and Resistant Strains in the Gonorrhea Mouse Model.

Antimicrob Agents Chemother 2019 Jan 14. Epub 2019 Jan 14.

Department of Microbiology and Immunology, Uniformed Services University of Health Sciences, Bethesda, MD, United States

There is a pressing need for drug development for gonorrhea. Here we describe pharmacokinetics/pharmacodynamics (PK/PD) analysis of extended-spectrum cephalosporins (ESC) against drug-susceptible and drug-resistant gonococcal strains in a murine genital tract infection model. PK determined in uninfected mice displayed a clear dose response in plasma levels following single doses of ceftriaxone (CRO) (intraperitoneal) or cefixime (CFM) (oral). Read More

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http://aac.asm.org/lookup/doi/10.1128/AAC.01644-18
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http://dx.doi.org/10.1128/AAC.01644-18DOI Listing
January 2019
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Associations Between Cannabis Use, Sexual Behavior, and Sexually Transmitted Infections/Human Immunodeficiency Virus in a Cohort of Young Men Who Have Sex With Men.

Sex Transm Dis 2019 Feb;46(2):105-111

From the Department of Epidemiology, Fielding School of Public Health.

Background: Among men who have sex with men (MSM) the relationship between sexually transmitted infections (STIs) and cannabis use is not well established. We assessed cannabis use, sexual behavior, and STIs including human immunodeficiency virus (HIV) in a diverse cohort of young MSM.

Methods: In Los Angeles, the mSTUDY cohort conducted visits every 6 months with 512 MSM between 2014 and 2017 collecting demographics, sexual behaviors, and reports of frequency of substance use. Read More

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http://dx.doi.org/10.1097/OLQ.0000000000000919DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6342487PMC
February 2019
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Case Report: Gonorrhea as a Cause of Exudative Tonsillitis.

Am Fam Physician 2019 Jan;99(2):77

Denver, CO, USA.

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January 2019
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Awareness and Interest in HIV Pre-Exposure Prophylaxis Among Street-Based Female Sex Workers: Results from a US Context.

AIDS Patient Care STDS 2019 Feb 11;33(2):49-57. Epub 2019 Jan 11.

1 Department of Health, Behavior, and Society, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland.

Pre-exposure prophylaxis (PrEP) has the potential to be an empowering HIV prevention tool among female sex workers (FSW), yet little is known about PrEP awareness and interest in this population. Sex workers and Police Promoting Health in Risky Environments (SAPPHIRE) is a prospective cohort study of street-based FSW in Baltimore, MD. A cross-sectional analysis explored awareness and interest in PrEP among HIV-negative FSW. Read More

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http://dx.doi.org/10.1089/apc.2018.0182DOI Listing
February 2019
5 Reads

Hormonal contraceptives and the acquisition of sexually transmitted infections: an updated systematic review.

Sex Transm Dis 2019 Jan 8. Epub 2019 Jan 8.

City University of New York, Graduate School of Public Health & Health Policy, New York, USA.

Background: Evidence suggests that some forms of hormonal contraception (HC) increase women's risk of non-HIV sexually transmitted infections (STIs), yet evidence has not been reviewed since 2008. We conducted an updated systematic review to incorporate studies published between January 2009 and June 2017 to examine the relationship between HCs and incident and/or recurrent STIs.

Methods: We searched PubMed and EMBASE to identify prospective studies comparing risk of Chlamydia trachomatis, Neisseria gonorrhoeae, human papillomavirus (HPV), herpes simplex virus type 2 (HSV-2), Treponema pallidum, or Trichomonas vaginalis, between women using HC vs. Read More

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http://dx.doi.org/10.1097/OLQ.0000000000000975DOI Listing
January 2019
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Trends in gonorrhoea infection and overseas sexual contacts among females attending a sexual health centre in Melbourne, Australia, 2008-2015.

Commun Dis Intell (2018) 2018 17;42. Epub 2018 Dec 17.

Melbourne Sexual Health Centre, Alfred Health, Melbourne, Victoria, Australia.

Introduction: There has been a steady increase in gonorrhoea cases among females in Australian major cities but the reasons remain unclear. The aim of this study was to identify the risk factors associated with gonorrhoea among females attending a sexual health centre in Melbourne.

Methods: Analysis of retrospective electronic patient records of females aged 16 to 80 years old attending the Melbourne Sexual Health Centre, Australia between 1st January 2008 and 20th March 2015. Read More

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December 2018
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Ophthalmia Neonatorum.

Authors:
Aik-Kah Tan

N Engl J Med 2019 Jan;380(2):e2

Normah Medical Specialist Center, Kuching, Malaysia

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http://dx.doi.org/10.1056/NEJMicm1808613DOI Listing
January 2019