18,456 results match your criteria Gonorrhea


Determinants of gonorrhea and syphilis infections among pregnant women attending antenatal clinic at Dilla University Referral Hospital, Ethiopia: Unmatched case-control study.

Womens Health (Lond) 2020 Jan-Dec;16:1745506520940095

School of Public Health, Hawassa University, Hawassa, Ethiopia.

Objective: This study was designed to determine the risk factors associated with gonorrhea and syphilis infections among pregnant women attending antenatal care clinic at Dilla University Referral Hospital.

Method: A hospital-based unmatched case-control study (64 cases and 128 controls) with 1:2 ratios was conducted from 29 January 2018 to 20 June 2018, at the antenatal care clinic of the Dilla University Referral Hospital. Venous blood and vaginal swab were collected to screen for gonorrhea and syphilis. Read More

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http://dx.doi.org/10.1177/1745506520940095DOI Listing

Disseminated gonococcal infection in a patient with paroxysmal nocturnal hemoglobinuria having received ravulizumab and meningococcal vaccine.

J Microbiol Immunol Infect 2020 Jun 30. Epub 2020 Jun 30.

Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan; Department of Tropical Medicine and Parasitology, National Taiwan University College of Medicine, Taipei, Taiwan; Department of Medical Research, China Medical University Hospital, Taichung, Taiwan; China Medical University, Taichung, Taiwan. Electronic address:

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http://dx.doi.org/10.1016/j.jmii.2020.06.013DOI Listing

Prevalence of mutations associated with resistance to macrolides and fluoroquinolones in Mycoplasma genitalium: a systematic review and meta-analysis.

Lancet Infect Dis 2020 Jul 2. Epub 2020 Jul 2.

Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Parkville, VIC, Australia; Melbourne Sexual Health Centre, Alfred Health, Melbourne, VIC, Australia; Central Clinical School, Monash University, Melbourne, VIC, Australia.

Background: Mycoplasma genitalium is now recognised as an important bacterial sexually transmitted infection. We summarised data from studies of mutations associated with macrolide and fluoroquinolone resistance in M genitalium to establish the prevalence of resistance. We also investigated temporal trends in resistance and aimed to establish the association between resistance and geographical location. Read More

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http://dx.doi.org/10.1016/S1473-3099(20)30154-7DOI Listing

The Impact of Pre-exposure Prophylaxis for Human Immunodeficiency Virus on Gonorrhea Prevalence.

Bull Math Biol 2020 Jul 1;82(7):85. Epub 2020 Jul 1.

Department of Applied Mathematics, University of Waterloo, 200 University Ave West, Waterloo, ON, N2L 3G1, Canada.

Pre-exposure prophylaxis (PrEP) has been shown to be highly effective in reducing the risk of HIV infection in gay and bisexual men who have sex with men (GbMSM). However, PrEP does not protect against other sexually transmitted infections (STIs). In some populations, PrEP has also led to riskier behavior such as reduced condom usage, with the result that the prevalence of bacterial STIs like gonorrhea has increased. Read More

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http://dx.doi.org/10.1007/s11538-020-00762-7DOI Listing

Changing demography of genital chlamydia, gonorrhea, genital herpes, condyloma and syphilis infections in Japan.

Jpn J Infect Dis 2020 Jun 30. Epub 2020 Jun 30.

National Institute of Infectious Diseases, Japan.

There was epidemiological correlation in time and in space between gonorrhea and genital chlamydia and between condyloma and genital herpes. There was, however, no correlation in other combinations, such as, gonorrhea and condyloma, genital herpes and chlamydia, etc. The annual incidence of gonorrhea and that of genital chlamydia were mono-phasic with a peak in 2005-2006. Read More

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http://dx.doi.org/10.7883/yoken.JJID.2020.005DOI Listing

Prevalence of and antibiotic resistance-associated mutations in an Icelandic STI population, and comparison of the S-DiaMGTV and Aptima assays for diagnosis.

J Clin Microbiol 2020 Jul 1. Epub 2020 Jul 1.

Department of Microbiology, Landspítali - The University Hospital of Iceland, Reykjavík, Iceland.

(MG) is prevalent among attendees in sexually transmitted infections (STI) clinics and therapy is hampered by rapidly rising levels of resistance to azithromycin and moxifloxacin. In this study we evaluated, for the first time in Iceland, the prevalence of MG and azithromycin and moxifloxacin resistance-associated mutations, and assessed the diagnostic performance of the CE/IVD-marked S-DiaMGTV (Diagenode Diagnostics) versus the US FDA/CE/IVD-approved Aptima MG (AMG; Hologic) for MG detection. From October 2018 to January 2019, urine and vaginal swabs were provided by male and female attendees at Iceland's only STI clinic. Read More

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http://dx.doi.org/10.1128/JCM.01084-20DOI Listing

Changing from clinician-collected to self-collected throat swabs for oropharyngeal gonorrhoea and chlamydia screening among men who have sex with men.

J Clin Microbiol 2020 Jul 1. Epub 2020 Jul 1.

Melbourne Sexual Health Centre, Alfred Health, Melbourne, Victoria, Australia.

The coronavirus (COVID-19) pandemic has led many clinics to move from clinician-collected to self-collected oropharyngeal swabs for the detection of sexually transmitted infections (STIs). Before this change, however, self-collection was primarily used for genital and anorectal infections with only limited studies on the performance of self-collected oropharyngeal swabs for oropharyngeal STIs. Melbourne Sexual Health Centre (MSHC) changed from clinician-collected to self-collected oropharyngeal swabs for oropharyngeal gonorrhoea and chlamydia screening on March 16, 2020 to reduce healthcare worker risk during the COVID-19 pandemic. Read More

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http://dx.doi.org/10.1128/JCM.01215-20DOI Listing

Risk-based screening to identify reproductive tract infection among HIV-infected women desiring use of intrauterine contraceptives.

BMJ Sex Reprod Health 2020 Jul 1. Epub 2020 Jul 1.

Division of Epidemiology and Biostatistics, University of Cape Town, Cape Town, South Africa.

Background: Reproductive tract infections (RTIs) are a major cause of morbidity and mortality, yet RTI testing remains limited in resource-constrained settings. We assessed performance of an existing RTI risk assessment screening tool among women living with HIV (WLHIV) considering intrauterine contraceptive (IUC) use.

Methods: We conducted a cross-sectional analysis among WLHIV screened for participation in an IUC trial in Cape Town, South Africa (NCT01721798). Read More

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http://dx.doi.org/10.1136/bmjsrh-2019-200494DOI Listing

MYCOPLASMA GENITALIUM AS A CAUSE OF PELVIC INFLAMMATORY DISEASE.

J Pediatr Adolesc Gynecol 2020 Jun 28. Epub 2020 Jun 28.

Department of Pediatrics, Division of Pediatric and Young Women's Gynecology, New York Medical College, Valhalla, NY.

Background: Mycoplasma genitalium is an increasingly recognized cause of pelvic inflammatory disease.

Case: A 17-year-old adolescent female presented with chronic pelvic pain and dysmenorrhea. Testing for Chlamydia trachomatis and Neisseria gonorrhea were negative. Read More

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http://dx.doi.org/10.1016/j.jpag.2020.06.015DOI Listing

Gonococcal resistance can be viewed productively as part of a syndemic of antimicrobial resistance: an ecological analysis of 30 European countries.

Antimicrob Resist Infect Control 2020 Jun 30;9(1):97. Epub 2020 Jun 30.

HIV/STI Unit, Institute of Tropical Medicine, 2000, Antwerp, Belgium.

Background: It is unclear how important bystander selection is in the genesis of antimicrobial resistance (AMR) in Neisseria gonorrhoeae.

Methods: We assessed bystander selection in a novel way. Mixed-effects linear regression was used to assess if country-level prevalence of gonococcal AMR in 30 European countries predicts homologous AMR in other bacteria. Read More

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http://dx.doi.org/10.1186/s13756-020-00764-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7325135PMC

Genomics against gonorrhoea.

Authors:
Nicholas Medland

Elife 2020 Jun 30;9. Epub 2020 Jun 30.

Kirby Institute, University of New South Wales, Sydney, Australia.

Surveillance strategies based on whole genome sequencing could help with the early identification and detection of new forms of drug-resistant gonorrhoea. Read More

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http://dx.doi.org/10.7554/eLife.59379DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7326486PMC

Factors associated with severity and resolution of intramuscular injection site pain following treatment for uncomplicated gonorrhoea: a prospective cohort study of GToG trial participants.

Sex Health 2020 Jun 29. Epub 2020 Jun 29.

Intramuscular injection (IMI) pain reduces the acceptability of treatment, but data identifying those at highest risk of severe pain following an injection are limited. This study identified factors associated with the severity, duration and resolution of IMI pain following treatment for uncomplicated gonorrhoea. Data from a subset of participants (aged 16-70 years) recruited between October 2014 and November 2016 into the 'Gentamicin for the treatment of gonorrhoea' trial in England were analysed. Read More

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http://dx.doi.org/10.1071/SH19176DOI Listing

Evaluation of Self-Collection as a Method of Extragenital STI Screening.

Mil Med 2020 Jun 27. Epub 2020 Jun 27.

Department of Infectious Diseases, Brooke Army Medical Center, Fort Sam Houston, TX 78234, USA.

Introduction: The goal of this study is to improve overall screening, detection, and treatment of Neisseria gonorrhea (GC) and Chlamydia trachomatis (CT) at our institution.

Materials And Methods: An observational study with two phases was conducted at a U.S. Read More

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http://dx.doi.org/10.1093/milmed/usaa123DOI Listing

Low HIV incidence among women following sexually transmitted infection does not support national pre-exposure prophylaxis recommendations.

AIDS 2020 Jul;34(9):1429-1431

Public Health-Seattle & King County HIV/STD Program.

: Current United States guidelines recommend that clinicians offer HIV pre-exposure prophylaxis (PrEP) to women with gonorrhea or syphilis. We estimated HIV incidence among women following a syphilis, gonorrhea, or chlamydia diagnosis among women in King County, WA using surveillance data from 2008 to 2018. Among women with diagnosed with gonorrhea and among women diagnosed with chlamydia the estimated HIV incidence rates were 0. Read More

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http://dx.doi.org/10.1097/QAD.0000000000002561DOI Listing

[Rapid testing for sexually transmitted infections].

MMW Fortschr Med 2020 Jun;162(Suppl 2):44-48

Immunschwäche-Ambulanz, Klinik und Poliklinik für Dermatologie, Universitätsklinikum Carl Gustav Carus an der Technischen Universität Dresden, Fetscherstraße 74, D-01307, Dresden, Deutschland.

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http://dx.doi.org/10.1007/s15006-020-0646-xDOI Listing

Epithelial Haven and Autophagy Breakout in Gonococci Infection.

Front Cell Dev Biol 2020 9;8:439. Epub 2020 Jun 9.

Departamento de Genética, Ecologia e Evolução, Instituto de Ciencias Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.

The World Health Organization (WHO) has estimated that in 2016, there were 87 million new cases of gonorrhea. Gonorrhea is caused by the sexually transmitted human-exclusive agent , a Gram-negative diplococcus that causes cervicitis in females and urethritis in males and may lead to more severe complications. Currently, there is no vaccine against . Read More

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http://dx.doi.org/10.3389/fcell.2020.00439DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7295977PMC

Preliminary assessment of antimicrobial activity and acute toxicity of norfloxacin chlorination by-product mixture.

Environ Sci Pollut Res Int 2020 Jun 23. Epub 2020 Jun 23.

Department of Sanitary and Environmental Engineering, Federal University of Minas Gerais (UFMG), Belo Horizonte, Minas Gerais, Brazil.

Among drugs and personal care products, antibiotics arouse interest since they are widely used in human and veterinary medicine and can lead to the development of bacterial resistance. Usually, sewage treatment does not remove most of these compounds. So, these drugs can reach water treatment plants (WTP), where disinfection with chlorine compounds is common. Read More

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http://dx.doi.org/10.1007/s11356-020-09748-3DOI Listing

Balanophora polyandra Griff. prevents dextran sulfate sodium-induced murine experimental colitis via the regulation of NF-κB and NLRP3 inflammasome.

Food Funct 2020 Jun 23. Epub 2020 Jun 23.

College of Medical Science, China Three Gorges University, Yichang, 443002, China. and Third-Grade Pharmacological Laboratory on Chinese Medicine Approved by State Administration of Traditional Chinese Medicine, China Three Gorges University, Yichang, 443002, China and Tumor Microenvironment and Immunotherapy Key Laboratory of Hubei province, China Three Gorges University, Yichang, 443002, China.

Balanophora polyandra Griff. (B. polyandra) is a folk medicine used as an antipyretic, antidote, haemostatic, dressing and haematic tonic, for the treatment of gonorrhea, syphilis, wounds, and the bleeding of the alimentary tract by the local people in China. Read More

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http://dx.doi.org/10.1039/c9fo02494hDOI Listing

Age, ethnic and travel-related disparities in kissing and sexual practices among heterosexual men in Melbourne, Australia.

Sex Health 2020 Jun;17(3):279-287

Melbourne Sexual Health Centre, Alfred Health, 580 Swanston Street, Carlton, Vic. 3053, Australia; and Central Clinical School, Monash University, 99 Commercial Road, Melbourne, Vic. 3004, Australia; and Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, 207 Bouverie Street, Carlton, Vic. 3053, Australia; and Corresponding authors. Emails:

Background The kissing practices of heterosexual men are not well understood, despite the potential of kissing to be a significant risk factor for gonorrhoea transmission. This study aimed to explore kissing and sex practices among heterosexual men.

Methods: A cross-sectional survey among heterosexual men attending the Melbourne Sexual Health Centre in 2016-2017 was conducted. Read More

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http://dx.doi.org/10.1071/SH19230DOI Listing

Optimising treatments for sexually transmitted infections: surveillance, pharmacokinetics and pharmacodynamics, therapeutic strategies, and molecular resistance prediction.

Lancet Infect Dis 2020 Jun 19. Epub 2020 Jun 19.

WHO Collaborating Centre for Gonorrhoea and Other Sexually Transmitted Infections and the Swedish Reference Laboratory for STIs, Department of Laboratory Medicine, Faculty of Medicine and Health, Örebro University, Örebro, Sweden.

Progressive antimicrobial resistance in Neisseria gonorrhoeae, Mycoplasma genitalium, and Trichomonas vaginalis has created a pressing need for treatment optimisations for sexually transmitted infections (STIs). In this Review, we aim to highlight urgent needs in global STI management, including: (1) improved surveillance to monitor antimicrobial resistance and clinical outcomes; (2) systematic pharmacokinetic and pharmacodynamic evaluations to ensure resistance suppression and bacterial eradication at all sites of infection; (3) development of novel, affordable antimicrobials; and (4) advancements in new molecular and point-of-care tests to detect antimicrobial resistance determinants. Antimicrobial resistance among STIs is a global public health crisis. Read More

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http://dx.doi.org/10.1016/S1473-3099(20)30171-7DOI Listing

Increasing Chlamydia and Gonorrhea Infections among Female Juveniles: The Need for Collaboration to Improve Treatment.

Cureus 2020 Jun 4;12(6):e8446. Epub 2020 Jun 4.

Emergency Medicine, Arrowhead Regional Medical Center, Colton, USA.

Background:  Youth in juvenile detention centers are at a high risk for sexually transmitted disease (STD). The current study assesses the trends of chlamydia and gonorrhea (GC) infections and treatment among females within a single county's juvenile correctional facilities.

Methods: This is a retrospective review of aggregate data of female adolescents between 12 and 18 years old who underwent STD screening from 2009 to 2016 in San Bernardino County. Read More

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http://dx.doi.org/10.7759/cureus.8446DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7301431PMC

Prescription Patterns of Wu Lin San Concentrated Extract Product for Cystitis in Taiwan: A Population-Based Study.

Evid Based Complement Alternat Med 2020 20;2020:2605462. Epub 2020 May 20.

PhD Program in Clinical Drug Development of Herbal Medicine, College of Pharmacy, Taipei Medical University, Taipei, Taiwan.

The indications for the concentrated extract product (CEP) of Wu Lin San (WLS) are urethritis, cystitis, and gonorrhea. In clinical settings, WLS is combined with other CEPs used. However, there are no prescribed guidelines of CEPs in Taiwan. Read More

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http://dx.doi.org/10.1155/2020/2605462DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7256769PMC

Outreach services to brothels facilitate sexually transmissible infection testing for Asian sex workers in regional Australia.

Sex Health 2020 Jun;17(3):301-302

HNE Sexual Health, Hunter New England Local Health District, Level 2, 670 Hunter Street, Newcastle West, NSW 2302, Australia; and School of Medicine and Public Health, University of Newcastle, University Drive, Callaghan, NSW 2308, Australia; and The Kirby Institute, UNSW Sydney, Level 6, Wallace Wurth Building, High Street, Kensington, NSW 2052, Australia.

Outreach services providing sexually transmissible infection (STI) testing on-site in brothels were introduced in 2012 by Pacific Clinic Newcastle, Australia. Asian female sex workers (FSW) were more likely than non-culturally and linguistically diverse (CALD) FSW to access testing via outreach services than in clinics (OR 2.38, 95% CI 1. Read More

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http://dx.doi.org/10.1071/SH19213DOI Listing

Current Perspectives on the Impact of Pre-Exposure Prophylaxis Stigma Regarding Men Who Have Sex with Men in the United States.

Authors:
Patrick D Herron

HIV AIDS (Auckl) 2020 18;12:187-192. Epub 2020 May 18.

Department of Family and Social Medicine, Albert Einstein College of Medicine, Bronx, NY, USA.

Pre-exposure prophylaxis or PrEP is a Food and Drug Administration approved human immunodeficiency virus (HIV) prevention tool that reduces the risk of infection by greater than 90%. While it does not provide protection against other sexually transmittable infections and blood-borne illnesses such as hepatitis C, syphilis, chlamydia, and gonorrhea, it is a highly effective in reducing the risk of transmission of HIV among men who have sex with men. Despite the success of PrEP, there remain barriers to PrEP uptake rooted in stigmatized perspectives shared by health professionals, patients, and community members. Read More

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http://dx.doi.org/10.2147/HIV.S214380DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7244237PMC

Sensitivity, specificity, inclusivity and exclusivity of the updated Aptima Combo 2 assay, which provides detection coverage of the new diagnostic-escape Chlamydia trachomatis variants.

BMC Infect Dis 2020 Jun 16;20(1):419. Epub 2020 Jun 16.

World Health Organization Collaborating Centre for Gonorrhoea and Other Sexually Transmitted Infections (STIs), National Reference Laboratory for STIs, Department of Laboratory Medicine, Clinical Microbiology, Faculty of Medicine and Health, Örebro University, SE-701 85, Örebro, Sweden.

Background: Four new variants of Chlamydia trachomatis (nvCTs), detected in several countries, cause false-negative or equivocal results using the Aptima Combo 2 assay (AC2; Hologic). We evaluated the clinical sensitivity and specificity, as well as the analytical inclusivity and exclusivity of the updated AC2 for the detection of CT and Neisseria gonorrhoeae (NG) on the automated Panther system (Hologic).

Methods: We examined 1004 clinical AC2 samples and 225 analytical samples spiked with phenotypically and/or genetically diverse NG and CT strains, and other potentially cross-reacting microbial species. Read More

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http://dx.doi.org/10.1186/s12879-020-05148-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7298785PMC
June 2020
2.613 Impact Factor

Evaluation of Text Message Reminders to Encourage Retesting for Chlamydia and Gonorrhea Among Female Patients at the Municipal Sexually Transmitted Disease Clinic in Seattle, Washington.

Sex Transm Dis 2020 07;47(7):458-463

From the Department of Epidemiology.

Background: United States guidelines recommend retesting for chlamydia (CT) and gonorrhea (GC) approximately 3 months after treatment, but adherence to these guidelines is poor.

Methods: In May 2016, the municipal sexually transmitted disease (STD) Clinic in Seattle, WA, integrated opt-in short message system (SMS) (text message) retesting reminders for female patients into our clinic's routine electronic intake. Women were asked if they wanted to receive an SMS reminder for retesting for GC/CT in 3 months. Read More

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http://dx.doi.org/10.1097/OLQ.0000000000001184DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7301878PMC

Early sex work initiation and its association with condomless sex and sexually transmitted infections among female sex workers in Iran.

Int J STD AIDS 2020 Jun;31(7):671-679

Department of Epidemiology, Key Populations Program, Center for Public Health and Human Rights, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.

Early sex work initiation among female sex workers (FSWs) increases their vulnerabilities to high-risk sexual practices and sexually transmitted infections (STIs). We examined the association of early sex work with condomless sex indicators, HIV, and other STIs, including human papillomavirus, chlamydia, trichomoniasis, syphilis, and gonorrhea, among FSWs in Iran. We recruited 1347 FSWs from 13 cities in 2015, with 1296 participants (94. Read More

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http://dx.doi.org/10.1177/0956462420913431DOI Listing

Lack of STI Treatment Accuracy When Relying on Syndromic Management in an Urgent Care Setting.

Sex Transm Dis 2020 Jun 8. Epub 2020 Jun 8.

UnityPoint Clinic - Waterloo.

Background: Chlamydia and gonorrhea are two of the most common sexually transmitted infections and patients are increasingly seeking care for them in urgent care clinics. Providers often rely on syndromic management due to prolonged test turnaround times which can result in inappropriate treatment.

Methods: This study retrospectively evaluated chlamydia and gonorrhea treatment accuracy of adults, men and women, aged 18 and older in four urgent cares in Northeast Iowa, using standard NAAT in a 6-month timeframe through medical records review. Read More

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http://dx.doi.org/10.1097/OLQ.0000000000001216DOI Listing

Pay-it-forward gonorrhoea and chlamydia testing among men who have sex with men in China: a randomised controlled trial.

Lancet Infect Dis 2020 Apr 28. Epub 2020 Apr 28.

University of North Carolina at Chapel Hill, Project-China, Guangzhou, China; London School of Hygiene and Tropical Medicine, London, UK. Electronic address:

Background: WHO recommends that men who have sex with men (MSM) receive gonorrhoea and chlamydia testing, but many evidence-based preventive services are unaffordable. The pay-it-forward strategy offers an individual a gift (eg, a test for sexually transmitted diseases) and then asks whether they would like to give a gift (eg, a future test) to another person. This study examined the effectiveness of a pay-it-forward programme to increase gonorrhoea and chlamydia testing among MSM in China. Read More

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http://dx.doi.org/10.1016/S1473-3099(20)30172-9DOI Listing
April 2020
22.433 Impact Factor

Transcriptional control of the gonococcal ompA gene by the MisR/MisS two-component regulatory system.

Sci Rep 2020 Jun 10;10(1):9425. Epub 2020 Jun 10.

Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA, 30032, USA.

Neisseria gonorrhoeae, the causative agent of gonorrhea, is an exclusive human pathogen whose growing antibiotic resistance is causing worldwide concern. The increasing rise of antibiotic resistance expressed by gonococci highlights the need to find alternative approaches to current gonorrhea treatment such as vaccine development or novel therapeutics. The gonococcal OmpA protein was previously identified as a potential vaccine candidate due to its conservation and stable expression amongst strains of Neisseria gonorrhoeae. Read More

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http://dx.doi.org/10.1038/s41598-020-66382-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7286886PMC
June 2020
5.078 Impact Factor

A population-specific optimized GeneXpert pooling algorithm for and to reduce cost of molecular STI screening in resource-limited settings.

J Clin Microbiol 2020 Jun 10. Epub 2020 Jun 10.

Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA 30322.

The sexually transmitted infections (STIs) chlamydia (CT) and gonorrhea (NG) are often asymptomatic in women and undetected by syndromic management, leading to complications such as pelvic inflammatory disease, infertility, and ectopic pregnancy. Molecular testing, such as the GeneXpert CT/NG assay, is highly sensitive, but cost restraints preclude implementation of these technologies in resource-limited settings. Pooled testing is one strategy to reduce the cost-per-sample, but the extent of savings depends on disease prevalence. Read More

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http://dx.doi.org/10.1128/JCM.00176-20DOI Listing

Antimicrobial Resistance of Neisseria Gonorrhoeae in a Newly Implemented Surveillance Program in Uganda: Surveillance Report.

JMIR Public Health Surveill 2020 Jun 10;6(2):e17009. Epub 2020 Jun 10.

Division of Infectious Diseases, Johns Hopkins School of Medicine, Baltimore, MD, United States.

Background: Neisseria gonorrhoeae (commonly known as gonorrhea) has developed resistance to all first-line therapy in Southeast Asia. East Africa has historically had absent or rudimentary gonorrhea surveillance programs and, while the existence of antimicrobial-resistant gonorrhea is recognized, the extent of its resistance is largely unknown. In 2016, the World Health Organization's Enhanced Gonococcal Antimicrobial Surveillance Program (EGASP) was initiated in Uganda to monitor resistance trends. Read More

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http://dx.doi.org/10.2196/17009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7315362PMC

, and among women with genitourinary infection and pregnancy-related complications in Tehran: A cross-sectional study.

Int J STD AIDS 2020 Jun 10:956462420922462. Epub 2020 Jun 10.

Faculty of Medicine, Centre for Clinical Research, The University of Queensland, Herston, Queensland, Australia.

The present study investigates the prevalence of (CT), (NG), and (TV) among women with genitourinary infection and pregnancy-related complications in Tehran. It also evaluates the demographic information, symptoms, and sequelae. Endocervical samples were obtained over a period of eight months from 360 women including 180 symptomatic patients and 180 patients with pregnancy-related complications and infertility. Read More

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http://dx.doi.org/10.1177/0956462420922462DOI Listing

Budgeting for comprehensive sexual and reproductive health and rights under universal health coverage.

Sex Reprod Health Matters 2020 Jun 9:1-26. Epub 2020 Jun 9.

Senior Research Associate, Guttmacher Institute, New York, NY, USA.

Achieving universal health coverage (UHC) for sexual and reproductive health (SRH) requires informed budgeting that is aligned with UHC objectives. We draw data from , to provide critical new country-level and regional, intervention-specific costs for provision of SRH services. AIU-2019 is a cost-outcomes analysis, undertaken from the health system perspective, which estimates the costs and impacts of offering SRH care in low- and middle-income countries (LMICs). Read More

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http://dx.doi.org/10.1080/26410397.2020.1779631DOI Listing

Trends and Characteristics of Sexually Transmitted Infections During Pregnancy: United States, 2016-2018.

Natl Vital Stat Rep 2020 Mar;69(3):1-11

Objectives-This report presents data on recent trends for three sexually transmitted infections (STIs)-chlamydia, gonorrhea, and syphilis-reported among women giving birth in the United States from 2016 through 2018, and rates by selected characteristics for 2018. Methods-Data are from birth certificates and are based on 100% of births registered in the United States for 2016, 2017, and 2018. Birth certificate data on infections during pregnancy are recommended to be collected from the mother's medical records (1). Read More

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Point-by-Point Progress: Gonorrhea Point of Care Tests.

Expert Rev Mol Diagn 2020 Jun 30:1-11. Epub 2020 Jun 30.

Division of Infectious Diseases, Department of Medicine, Johns Hopkins University , Baltimore, Maryland, USA.

Introduction: Point-of-care (POC) tests for (Ng) are urgently needed to control the gonorrhea epidemic, so patients can receive immediate diagnoses and treatment. While the advent of nucleic acid amplification tests (NAATs) has improved the accuracy of Ng identification, very few POC assays are able to provide results of such tests at the clinical visit. Additionally, antimicrobial resistance (AMR) presents a unique treatment challenge for Ng. Read More

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http://dx.doi.org/10.1080/14737159.2020.1778467DOI Listing

Neisseria gonorrhoeae Septic Arthritis with Contiguous Infection Consistent with Acute Osteomyelitis.

Sex Transm Dis 2020 Jun 2. Epub 2020 Jun 2.

Department of Internal Medicine, Section on Infectious Diseases.

Neisseria gonorrhoeae osteomyelitis is a rare complication of disseminated gonococcal infection (DGI). As the rates of N. gonorrhea continue to increase in the U. Read More

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http://dx.doi.org/10.1097/OLQ.0000000000001212DOI Listing

Interest in Taking HIV Pre-exposure Prophylaxis Is Associated with Behavioral Risk Indicators and Self-Perceived HIV Risk Among Men Who Have Sex with Men Attending HIV Testing Venues in Sweden.

Arch Sex Behav 2020 Aug 3;49(6):2165-2177. Epub 2020 Jun 3.

Clinical Infection Medicine, Department of Translational Medicine, Lund University, Malmö, Sweden.

This study explored factors associated with interest in taking PrEP among men who have sex with men (MSM) attending HIV testing venues in Sweden. Data from 658 HIV-negative respondents, surveyed by a questionnaire at six sites, were analyzed descriptively and by univariable and multivariable logistic regression. A total of 453 (68. Read More

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http://dx.doi.org/10.1007/s10508-020-01740-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7316853PMC

Fifteen years of a nationwide culture collection of Neisseria gonorrhoeae antimicrobial resistance in Portugal.

Eur J Clin Microbiol Infect Dis 2020 Jun 3. Epub 2020 Jun 3.

National Reference Laboratory for Sexually Transmitted Infections, Department of Infectious Diseases, National Institute of Health, Avenida Padre Cruz, 1649-016, Lisbon, Portugal.

Neisseria gonorrhoeae antimicrobial resistance (AMR) and gonorrhea disease burden remain major public health concerns worldwide. To contribute to the supranational demands to monitor and manage the spread of antimicrobial-resistant N. gonorrhoeae, the Portuguese NIH promoted the creation of the National Laboratory Network for Neisseria gonorrhoeae Collection (PTGonoNet). Read More

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http://dx.doi.org/10.1007/s10096-020-03907-7DOI Listing
June 2020
2.668 Impact Factor

Acute septic elbow monoarthritis with associated Neisseria gonorrhoeae bacteraemia: an uncommon presentation of an old disease.

Infez Med 2020 Jun;28(2):253-257

Division of Infectious Diseases, Department of Medicine, University of Miami, Miller School of Medicine, Miami, Florida, USA.

Neisseria gonorrhoeae is an uncommon present-day cause of septic arthritis. It is generally seen in the younger patient population and is often difficult to isolate in the lab. Blood cultures performed as routine work are usually negative, and when positive tend to be seen in the classic form of disseminated gonococcal infection. Read More

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Fracking and risky sexual activity.

J Health Econ 2020 May 15;72:102322. Epub 2020 May 15.

Montana State University, United States.

This paper examines the impact of the U.S. fracking boom on local STI transmission rates and prostitution activity as measured by online prostitution review counts. Read More

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http://dx.doi.org/10.1016/j.jhealeco.2020.102322DOI Listing

Diagnosis and treatment of gonorrhoea: 2019 Belgian National guideline for primary care.

Acta Clin Belg 2020 Jun 2:1-9. Epub 2020 Jun 2.

Department of Clinical Sciences, Institute of Tropical Medicine , Antwerp, Belgium.

Objectives: Gonorrhoea continues to be a public health concern in Belgium with pharyngeal and rectal infections increasing in persons with high-risk sexual behaviour. Belgian health care practitioners rely on international guidance when managing gonorrhoea resulting in non-adapted suboptimal care for the Belgian patient. This guideline will rectify this situation. Read More

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http://dx.doi.org/10.1080/17843286.2020.1773111DOI Listing

Antimicrobial susceptibility profile of Gonococcal isolates obtained from men presenting with urethral discharge in Addis Ababa, Ethiopia: Implications for national syndromic treatment guideline.

PLoS One 2020 1;15(6):e0233753. Epub 2020 Jun 1.

Clinical Bacteriology and Mycology, Ethiopian Public Health Institute Ethiopia, Addis Ababa, Ethiopia.

Background: Neisseria gonorrhoeae (gonococcus) is the etiologic agent for the sexually transmitted Infection gonorrhea, a disease with a significant global public health impact. The treatment regimen for gonorrhea has been changed frequently over the past few decades due to the organism's propensity for developing antibiotic resistance. This study investigated antimicrobial susceptibility patterns of quinolones, third-generation cephalosporin, and other relevant antimicrobials found in N. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0233753PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7263590PMC

Sustained transmission of the ceftriaxone-resistant Neisseria gonorrhoeae FC428 clone in China.

J Antimicrob Chemother 2020 May 30. Epub 2020 May 30.

Institute of Dermatology, Chinese Academy of Medical Sciences & Peking Union Medical College, Nanjing, China.

Background: Ceftriaxone resistance in Neisseria gonorrhoeae has become an imminent threat to effective control of gonorrhoea globally. In recent years, the ceftriaxone-resistant FC428 clone has shown international dissemination. After our first report of the FC428 clone in China in 2016, we now describe another six cases of FC428-related ceftriaxone-resistant N. Read More

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http://dx.doi.org/10.1093/jac/dkaa196DOI Listing

Cryo-EM Structures of a Gonococcal Multidrug Efflux Pump Illuminate a Mechanism of Drug Recognition and Resistance.

mBio 2020 May 26;11(3). Epub 2020 May 26.

Department of Pharmacology, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA

is an obligate human pathogen and causative agent of the sexually transmitted infection (STI) gonorrhea. The most predominant and clinically important multidrug efflux system in is the ultiple ransferrable esistance (Mtr) pump, which mediates resistance to a number of different classes of structurally diverse antimicrobial agents, including clinically used antibiotics (e.g. Read More

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http://dx.doi.org/10.1128/mBio.00996-20DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7251214PMC

Molecular Insight into TdfH-Mediated Zinc Piracy from Human Calprotectin by Neisseria gonorrhoeae.

mBio 2020 May 26;11(3). Epub 2020 May 26.

Center for Translational Immunology, Institute for Biomedical Sciences, Georgia State University, Atlanta, Georgia, USA

, responsible for the sexually transmitted infection gonorrhea, is an obligate human pathogen exquisitely adapted for survival on mucosal surfaces of humans. This host-pathogen relationship has resulted in evolution by of pathways that enable the use of host metalloproteins as required nutrients through the deployment of outer membrane-bound TonB-dependent transporters (TdTs). Recently, a TdT called TdfH was implicated in binding to calprotectin (CP) and in removal of the bound zinc (Zn), enabling gonococcal growth. Read More

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http://dx.doi.org/10.1128/mBio.00949-20DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7251212PMC

Factors associated with interest in bacterial sexually transmitted infection vaccines at two large sexually transmitted infection clinics in British Columbia, Canada.

Sex Transm Infect 2020 May 26. Epub 2020 May 26.

British Columbia Centre for Disease Control, Vancouver, British Columbia, Canada.

Objective: To explore sexually transmitted infection (STI) clinic client attitudes and preferences towards STI vaccines and STI vaccine programming in an urban clinic setting.

Methods: A 31-item questionnaire was administered during check-in by clinic clerical staff at two STI clinics in Vancouver, Canada. Demographic characteristics and preferences were summarised descriptively. Read More

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http://dx.doi.org/10.1136/sextrans-2019-054311DOI Listing

[Analysis on infection status and related factors in outpatients of sexually transmitted diseases in Shenzhen].

Zhonghua Liu Xing Bing Xue Za Zhi 2020 May;41(5):743-746

Institute of Dermatology and Hospital for Skin Diseases, Chinese Academy of Medical Sciences and Peking Union Medical Collage, Nanjing 210042, China; National Center for STD Control, Chinese Center for Disease Control and Prevention, Nanjing 210042, China.

To understand the prevalence of (NG) infection and related factors in outpatients of sexually transmitted disease (STD) in Shenzhen and provide scientific evidence for targeted intervention. A cross-sectional study was conducted in STD outpatients who were aged 18-49 years, had had sexual intercourse, had not received antibiotics in the last 2 weeks and sought medical cares in 22 medical institutions in 6 districts of Shenzhen from 15 April, 2018 to 16 May, 2018, their basic information and urine samples were collected, and NG in urine sample was detected by nucleic acid amplification test. Logistic regression analysis was conducted to identify the related factors for NG infection. Read More

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http://dx.doi.org/10.3760/cma.j.cn112338-20190711-00513DOI Listing

Effects of stem bark aqueous extract of Fagara tessmannii Engl (Rutaceae) on cardiovascular risks related to monosodium glutamate-induced obesity in rat: In vivo and in vitro assessments.

J Ethnopharmacol 2020 May 22;260:112972. Epub 2020 May 22.

Department of Animal Biology and Physiology, Laboratory of Animal Physiology, University of Yaoundé I, P.O. Box 812, Yaoundé, Cameroon. Electronic address:

Ethnopharmacological Relevance: Fagara tessmannii is a shrub of the African rainforests in South-West, Centre, South and East provinces in Cameroon. It is used in traditional medicine for the treatment of tumors, swellings, inflammation, gonorrhoea, schistosomiasis, antifungal, heart diseases and as anti-hypertensive.

Aim Of The Study: We investigated the potential effects of F. Read More

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http://dx.doi.org/10.1016/j.jep.2020.112972DOI Listing
May 2020
2.998 Impact Factor