19,098 results match your criteria Gonorrhea


Trends in asymptomatic STI among HIV-positive MSM and lessons for systematic screening.

PLoS One 2021 24;16(6):e0250557. Epub 2021 Jun 24.

Réseau Ville-Hôpital, Service de Médecine Interne, Hôpital Foch, Suresnes, France.

The burden of STIs is particularly high in HIV-infected MSM patients. A recent increase in STIs prevalence has been noticed in the US and western European countries. We aim to assess trends in asymptomatic STIs following the publication of recommendations for STIs screening, i. Read More

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Transient association between semen exposure and biomarkers of genital inflammation in South African women at risk of HIV infection.

J Int AIDS Soc 2021 Jun;24(6):e25766

Centre for the AIDS Programme of Research in South Africa (CAPRISA), University of KwaZulu-Natal, Durban, South Africa.

Introduction: Semen induces mucosal changes in the female reproductive tract to improve pregnancy outcomes. Since semen-induced alterations are likely short-lived and genital inflammation is linked to HIV acquisition in women, we investigated the contribution of recent semen exposure on biomarkers of genital inflammation in women at high HIV risk and the persistence of these associations.

Methods: We assessed stored genital specimens from 152 HIV-negative KwaZulu-Natal women who participated in the CAPRISA 008 trial between November 2012 and October 2014. Read More

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Phylogenomic analysis reveals persistence of gonococcal strains with reduced-susceptibility to extended-spectrum cephalosporins and mosaic penA-34.

Nat Commun 2021 06 21;12(1):3801. Epub 2021 Jun 21.

Division of STD Prevention, Centers for Disease Control and Prevention, Atlanta, GA, USA.

The recent emergence of strains of Neisseria gonorrhoeae associated with treatment failures to ceftriaxone, the foundation of current treatment options, has raised concerns over a future of untreatable gonorrhea. Current global data on gonococcal strains suggest that several lineages, predominately characterized by mosaic penA alleles, are associated with elevated minimum inhibitory concentrations (MICs) to extended spectrum cephalosporins (ESCs). Here we report on whole genome sequences of 813 N. Read More

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Free online chlamydia and gonorrhoea urine test request in Queensland, Australia: convenience of home sample collection versus pathology collection centre attendance for faster results.

Sex Health 2021 Jun 21. Epub 2021 Jun 21.

Background: A free online chlamydia and gonorrhoea urine testing service (Webtest) is available for people living in Queensland, Australia. There are two options to provide a urine sample: at a pathology collection centre or by using a home mailing kit. The study aimed to trial these two testing options designed for young people and describe which is the preferred testing choice. Read More

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Sexually transmitted infection laboratory testing and education trends in US outpatient physician offices, 2009-2016.

Fam Med Community Health 2021 Jun;9(3)

College of Pharmacy, The University of Texas at Austin, San Antonio, Texas, USA

Objective: To describe national rates of sexually transmitted infection (STI) testing and education overall and among patient subgroups in US outpatient physician offices from 2009 to 2016.

Design: This was a cross-sectional study of the Centers for Disease Control and Prevention's National Ambulatory Medical Care Survey from 2009 to 2016. Data weights were applied to extrapolate to national estimates. Read More

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Economic evaluation of point-of-care testing and treatment for sexually transmitted and genital infections in pregnancy in low- and middle-income countries: A systematic review.

PLoS One 2021 17;16(6):e0253135. Epub 2021 Jun 17.

The Kirby Institute, University of New South Wales, Sydney, Australia.

Background: Sexually transmitted and genital infections in pregnancy are associated with adverse pregnancy and birth outcomes. Point-of-care tests for these infections facilitate testing and treatment in a single antenatal clinic visit and may reduce the risk of adverse outcomes. Successful implementation and scale-up depends on understanding comparative effectiveness of such programmes and their comparative costs and cost effectiveness. Read More

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Visible colorimetric growth indicators of Neisseria gonorrhoeae for low-cost diagnostic applications.

PLoS One 2021 17;16(6):e0252961. Epub 2021 Jun 17.

Sibley School of Mechanical and Aerospace Engineering, Cornell University, Ithaca, New York, United States of America.

N. gonorrhoeae is one of the most pressing antibiotic resistant threats of our time and low-cost diagnostics that can easily identify antibiotic resistance are desperately needed. However, N. Read More

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Social and Behavioral Correlates of Sexually Transmitted Infections among Men who Have Sex with Men who Use Alcohol in the San Francisco Bay Area.

Am J Mens Health 2021 May-Jun;15(3):15579883211026830

Department of Community Health Systems, School of Nursing, University of California, San Francisco, CA, USA.

The risk of acquiring sexually transmitted infections (STIs) among men who have sex with men (MSM) is driven by various socio-behavioral factors. From 2015-2017, 247 MSM ≥ 18 years-old who reported alcohol use in the past year, were recruited into a cross-sectional study in San Francisco. Participants completed a survey assessing socio-demographics, substance use and treatment, sexual behaviors, HIV status and self-reported STI diagnosis in the past 6 months. Read More

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Epidemiology of reported HIV and other sexually transmitted infections during the COVID-19 pandemic, New York City.

J Infect Dis 2021 Jun 16. Epub 2021 Jun 16.

Bureau of Sexually Transmitted Infections, New York City Department of Health and Mental Hygiene, New York, NY, USA.

Early in the COVID-19 crisis, a statewide executive order ("PAUSE") severely restricted the movement of New Yorkers from March 23-June 7, 2020. We used NYC surveillance data for HIV, chlamydia, gonorrhea, and syphilis to describe trends in diagnosis and reporting surrounding PAUSE. During PAUSE, the volume of positive HIV/STI tests, and diagnoses of HIV, chlamydia, gonorrhea, and syphilis declined substantially, reaching a nadir in April before rebounding. Read More

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Sperm parameters and mitochondrial DNA sequence variants among patients at a fertility clinic in Ghana.

PLoS One 2021 15;16(6):e0252923. Epub 2021 Jun 15.

Department of Biochemistry, Cell and Molecular Biology, University of Ghana, Legon, Accra, Ghana.

Purpose: The present study sought to investigate the common abnormalities and mtDNA mutations in the sperm of Ghanaian men attending the fertility Clinic at the Korle-Bu Teaching Hospital (KBTH). The study therefore provides a baseline data mtDNA mutations in a cross-section of Ghanaian men on referral to the fertility clinic at the KBTH.

Materials And Methods: The semen of 55 men attending the fertility clinic were collected from the Urology and the Obstetrics and Gynaecology Departments of the KBTH. Read More

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Antimicrobial resistance and molecular epidemiological typing of Neisseria gonorrhoeae isolates from Kyrgyzstan in Central Asia, 2012 and 2017.

BMC Infect Dis 2021 Jun 12;21(1):559. Epub 2021 Jun 12.

WHO Collaborating Centre for Gonorrhoea and Other STIs, National Reference Laboratory for STIs, Department of Laboratory Medicine, Clinical Microbiology, Faculty of Medicine and Health, Örebro University Hospital, SE-701 85, Örebro, Sweden.

Background: Gonorrhoea and antimicrobial resistance (AMR) in Neisseria gonorrhoeae are significant public health concerns globally. Nearly no gonococcal AMR data are available from Central Asia, and no data from Kyrgyzstan has been published. We examined, for the first time, AMR and molecular epidemiology of N. Read More

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Genus Pterocarpus: A Review of Ethnopharmacology, Phytochemistry, Biological Activities, and Clinical Evidence.

J Ethnopharmacol 2021 Jun 8:114316. Epub 2021 Jun 8.

Department of Pharmaceutical Technology, Kulliyyah of Pharmacy, International Islamic University Malaysia, Kuantan, 25200, Malaysia. Electronic address:

Ethnopharmacological Relevance: The genus Pterocarpus (Fabaceae) has about 46 species that are distributed over Asia, especially Indonesia, Africa, and several countries in America. Particularly, P. indicus and P. Read More

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Ethnomedicinal uses, phytochemistry, pharmacological activities and toxicological profile of Glycosmis pentaphylla (Retz.) DC.: A review.

J Ethnopharmacol 2021 Jun 8;278:114313. Epub 2021 Jun 8.

Department of Pharmacy, International Islamic University Chittagong, Chittagong, 4318, Bangladesh; Faculty of Pharmacy, Universiti Kebangsaan Malaysia, 50300, Kuala Lumpur, Malaysia. Electronic address:

Ethnopharmacological Relevance: Glycosmis pentaphylla (Retz.) DC. is a perennial shrub indigenous to the tropical and subtropical regions of India, China, Sri Lanka, Myanmar, Bangladesh, Indonesia, Malaysia, Thailand, Vietnam, Philippine, Java, Sumatra, Borneo and Australia. Read More

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Society for Maternal-Fetal Medicine (SMFM) Consult Series #56: Hepatitis C in Pregnancy: Updated Guidelines.

Am J Obstet Gynecol 2021 Jun 8. Epub 2021 Jun 8.

In the United States, it is estimated that 1% to 4% of pregnant women are infected with hepatitis C virus, which carries approximately a 5% risk of transmission from mother to infant. Hepatitis C virus can be transmitted to the infant in utero or during the peripartum period, and infection during pregnancy is associated with an increased risk of adverse fetal outcomes, including fetal growth restriction and low birthweight. The purpose of this document is to discuss the current evidence, provide updated recommendations regarding screening, review treatment, and address management of hepatitis C virus during pregnancy. Read More

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Dynamics of Drug Resistance: Optimal Control of an Infectious Disease.

Oper Res 2019 May-Jun;67(3):599-904. Epub 2019 May 10.

Division of Health Policy & Management, School of Public Health, University of Minnesota, Minneapolis, MN.

Antimicrobial resistance is a significant public health threat. In the U.S. Read More

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Prevalence of Chlamydia trachomatis Infection in Young Women and Associated Predictors.

Sex Transm Dis 2021 Jan 12. Epub 2021 Jan 12.

*School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA †Departments of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA ‡Departments of Pediatrics, University of Alabama at Birmingham, Birmingham, AL, USA §Emergency Medicine; University of Alabama at Birmingham, Birmingham, AL, USA ¶Department of Microbiology and Immunology, University of Arkansas for Medical Sciences, Little Rock, AR, USA.

Background: Chlamydia trachomatis (CT) infection remains highly prevalent and young women are disproportionately affected. Most CT-infected women are asymptomatic and their infection often goes unrecognized and untreated. We hypothesized that testing for active CT infection with molecular diagnostics and obtaining a reported history of CT infection underestimates the prevalence of current and past CT infection, and incorporating serum CT antibody testing in addition to these other prevalence measures would generate more accurate estimates of the prevalence of CT infection in asymptomatic young women. Read More

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January 2021

The estimated impact of implementing a funding allocation formula on the number of gonorrhea cases in the United States, 2014-2018.

Sex Transm Dis 2021 Feb 11. Epub 2021 Feb 11.

National Center for HIV, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, GA.

Background: The Centers for Disease Control and Prevention (CDC) allocates funds annually to state and local programs in the United States to monitor and prevent sexually transmitted diseases (STDs). In 2014 a funding formula was implemented to allocate prevention funds to jurisdictions according to their STD burden and population size. We estimated the effect of implementing the funding formula in terms of gonorrhea cases averted from 2014-2018, a period during which inflation-adjusted CDC STD prevention funding declined. Read More

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February 2021

Improved gonorrhea and chlamydia testing among men who have sex with men living with HIV through implementation of self-collected tests.

Sex Transm Dis 2021 Mar 16. Epub 2021 Mar 16.

1California Prevention Training Center, University of California San Francisco, San Francisco, CA 2Kaiser Permanente Regional Laboratory, Berkeley, CA 3Kaiser Permanente Northern California Division of Research, Oakland, CA 4The Permanente Medical Group, Oakland, CA.

We implemented self-collected gonorrhea/chlamydia (GC/CT) testing in 17 medical centers in California serving men who have sex with men living with HIV. From 2012-2018, GC/CT testing increased from 45.2% to 63. Read More

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Rectal douching and anal human papillomavirus among young men who have sex with men in China.

Sex Transm Dis 2021 Mar 16. Epub 2021 Mar 16.

1School of Public Health, Sun Yat-sen University, Guangzhou, Guangdong 510080, China. 2School of Public Health, Southwest Medical University, Luzhou, Sichuan 646000, China. 3School of Public Health (Shenzhen), Sun Yat-sen University, Shenzhen, Guangdong 510006, China. 4Department of AIDS/STD Control and Prevention, Chongqing Center for Disease Control and Prevention, Chongqing 400042, China. 5Department of AIDS/STD Control and Prevention, Tianjin Center for Disease Control and Prevention, Tianjin 300011, China. 6Nanshan Center for Chronic Disease Control, Shenzhen 518000, China. 7Kirby Institute, University of New South Wales, Sydney, Australia.

Background: Young men who have sex with men (YMSM) are particularly at increased risk of human papillomavirus (HPV) infection and related malignancies. Rectal douching, commonly practiced among MSM, has been associated in HIV, chlamydia, gonorrhea and viral hepatitis in cross-sectional studies. We conducted this study to understand the association between self-reported rectal douching and anal HPV among YMSM in China. Read More

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Recurrent sexually transmitted infections among a cohort of men who have sex with men using pre-exposure prophylaxis in Belgium are highly associated with sexualized drug use.

Sex Transm Dis 2021 Mar 16. Epub 2021 Mar 16.

1 STI Reference Laboratory, Clinical Reference Laboratory, Department of Clinical Sciences, Institute of Tropical Medicine, Belgium 2 HIV/STD Unit, Department of Public Health, Institute of Tropical Medicine, Belgium 3 STI clinic, Department of Clinical Sciences, Institute of Tropical Medicine, Belgium 4 Clinical Trials Unit, Department of Clinical Sciences, Institute of Tropical Medicine, Belgium.

Background: Men who have sex with men (MSM) experiencing recurrent STIs may play a crucial role in the STI epidemic. However, there is limited understanding of what kind of behaviour leads to recurrent STIs.

Methods: A total of 179 MSM using PrEP were followed up for 18 months and were screened quarterly for chlamydia, gonorrhoea, and syphilis from 2015-2018 in Belgium. Read More

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Medicaid Expansion and Rates of Reportable Sexually Transmitted Infections in the United States A County-Level Analysis.

Sex Transm Dis 2021 Mar 16. Epub 2021 Mar 16.

1Rietmeijer Consulting, LLC 2Denver Public Health Department, Denver Health and Hospital 3Colorado School of Public Health, University of Colorado Denver.

Chlamydia, gonorrhea, and primary/secondary syphilis rates in 2018 were significantly higher in counties located in states without Medicaid expansion compared to those with Medicaid expansion. For STI combined, 59.9% of counties without Medicaid expansion were in the highest two STI rate quartiles compared to 42. Read More

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Utility of whole genome sequencing in assessing and enhancing partner notification of Neisseria gonorrhoeae infection.

Sex Transm Dis 2021 Mar 12. Epub 2021 Mar 12.

1Leeds Teaching Hospitals NHS Trust, UK 2Leeds Institute for Medical Research, Faculty of Medicine and Health, University of Leeds, UK 3Leeds Sexual Health, UK 4Nuffield Department of Medicine, University of Oxford, UK 5Public Health England, UK 6NIHR Oxford Biomedical Research Centre, University of Oxford, UK 7NIHR Health Protection Research Centre in Antimicrobial Resistance and Healthcare Associated Infections, University of Oxford, UK.

Background: Gonorrhea is a sexually transmitted infection of global concern. We investigated whole genome sequencing (WGS) as a tool to measure and enhance partner notification (PN) in gonorrhea management.

Methods: Between May-November 2018, all N. Read More

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Prevalence and Clinical Manifestations of Penile Gonococcal Cutaneous and Accessory Gland Infections in Men with Gonorrhea.

Sex Transm Dis 2021 Mar 12. Epub 2021 Mar 12.

1Department of Dermatology, First People's Hospital of Changshu City, Changshu Hospital Affiliated to Soochow University, Changshu, Jiangsu Province215500, P. R. China 2Department of Dermatology, Traditional Chinese Medical Hospital of Changshu City, Changshu, Jiangsu Province215500, P. R. China 3Department of Urinary Surgery, First People's Hospital of Changsha City, Changshu Hospital Affiliated to Soochow University, Changshu, Jiangsu Province215500, P.R. China 4Department of Clinical Laboratory, First People's Hospital of Changshu City, Changshu Hospital Affiliated to Soochow University, Changshu, Jiangsu Province215500, P. R China.

Background: No studies have focused on the prevalence and clinical manifestations of penile gonococcal cutaneous and accessory gland infections in men with gonorrhea.

Methods: We enrolled patients with penile gonococcal cutaneous and accessory gland infections and patients with urethral gonorrhea from January 2014 to February 2020. Demographic data, occurrence sites, and manifestations of all patients were recorded. Read More

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A Narrative Review of Where We Are With Point-Of-Care STI Testing in the United States.

Sex Transm Dis 2021 May 14. Epub 2021 May 14.

1Division of Infectious Diseases, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland.

Introduction: Point-of-care (POC) tests enable immediate diagnosis and targeted treatment for sexually transmitted infections (STIs), which could accelerate control of ongoing epidemics. Although older nucleic acid amplification tests (NAATs) have improved the accuracy of lab-based tests for STIs, newer POC tests can facilitate control efforts. We sought to review the performance and time-to-result of POC assays for STIs in the last ten years. Read More

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A Collaborative Intervention between Emergency Medicine and Infectious Diseases to Increase Syphilis and HIV Screening in the Emergency Department.

Sex Transm Dis 2021 Jun 10. Epub 2021 Jun 10.

Division of Infectious Diseases, The Ohio State University College of Medicine, Columbus, Ohio, USA Sexual Health Clinic, Columbus Public Health, Columbus, Ohio, USA Department of Emergency Medicine, The Ohio State University College of Medicine, Columbus, Ohio, USA Division of General Internal Medicine, The Ohio State University College of Medicine, Columbus, Ohio, USA.

Background: Sexually transmitted infections (STIs) are a common reason for evaluation in the emergency department (ED). Given the overlapping risk factors for STIs, patients screened for gonorrhea and chlamydia should be tested for syphilis and HIV. Syphilis and HIV testing rates in the ED have been reported to be low. Read More

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Beyond the binary: sexual health outcomes of transgender and non-binary service users of an online sexual health service.

Int J STD AIDS 2021 Jun 9:956462420982830. Epub 2021 Jun 9.

Preventx Limited, Sheffield, UK.

Sexual health data on transgender and non-binary (TNB) people in the United Kingdom are limited. TNB individuals experience significant socioeconomic and stigma-related disadvantages. Sexual health morbidity and unmet need is likely to be significant. Read More

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The impact of physical restriction measures imposed during the two waves of COVID-19 on chlamydia and gonorrhea diagnoses in Belgium. Results of an sexually transmitted infection clinic.

Int J STD AIDS 2021 Jun 5:9564624211013289. Epub 2021 Jun 5.

National Reference Center for Sexually Transmitted Infections, Clinical Reference Laboratory, Department of Clinical Sciences, 567788Institute of Tropical Medicine, Antwerp, Belgium.

During the first two waves of COVID-19, several physical restriction measurements were imposed in Belgium. Our aim was to explore the impact of these restriction measures on the number of tests and positivity rate of (CT) (NG) before, during, and after the two lockdowns in Belgium. molecular data of a Belgian STI clinic were extracted for 2019 and 2020, and both years were divided into four periods (pre-lockdown 1, lockdown 1, after lockdown 1, and lockdown 2). Read More

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Genomic surveillance of in the Philippines, 2013-2014.

Western Pac Surveill Response J 2021 Jan-Mar;12(1):17-25. Epub 2021 Feb 26.

These authors contributed equally to this work.

Antimicrobial-resistant is a major threat to public health and is of particular concern in the Western Pacific Region, where the incidence of gonorrhoea is high. The Antimicrobial Resistance Surveillance Program (ARSP) has been capturing information on resistant gonorrhoea since 1996, but genomic epidemiology studies on this pathogen are lacking in the Philippines. We sequenced the whole genomes of 21 isolates collected in 2013-2014 by ARSP. Read More

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February 2021