17,786 results match your criteria Gonococcal Infections


Extragenital Screening for Chlamydia and Gonorrhea Among Adolescents and Young Adults at a Sexual Health Clinic.

Nurs Womens Health 2020 Jul 7. Epub 2020 Jul 7.

Objective: To increase screening rates for oropharyngeal and rectal (extragenital) chlamydia and gonorrhea infections among adolescents and young adults by 20% and for 90% of nurses to demonstrate a change in behavior and knowledge surrounding extragenital screening.

Design: A pre- and posttest design to evaluate nurse knowledge and the percentage of extragenital chlamydia and gonorrhea screenings completed before and after a 2-month intervention period.

Setting: Reproductive health clinic for adolescents and young adults up to age 25 years in the Twin Cities metropolitan area of Minnesota. Read More

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http://dx.doi.org/10.1016/j.nwh.2020.05.007DOI Listing

Epidemiologic treatment of contacts to Neisseria gonorrhea and Chlamydia trachomatis infection in STD clinic patients in Seattle, WA 1994-2018.

Sex Transm Dis 2020 Jul 6. Epub 2020 Jul 6.

Department of Medicine, Division of Infectious Diseases, University of Washington, Seattle, WA.

Introduction: Current Centers for Disease Control and Prevention (CDC) guidelines recommend that clinicians empirically treat the sex partners of persons with Neisseria gonorrhoeae (GC) or Chlamydia trachomatis (CT) infection before confirming that they are infected. It is possible that this practice, known as epidemiological treatment, results in overtreatment of uninfected persons and may contribute to development of antimicrobial resistance. We sought to quantify the number of patients who received epidemiologic treatment and the proportion overtreated. Read More

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http://dx.doi.org/10.1097/OLQ.0000000000001234DOI Listing

Gonococcal osteomyelitis in a pediatric patient with disseminated gonococcal infection: Implications for antimicrobial management.

IDCases 2020 18;21:e00875. Epub 2020 Jun 18.

Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, 500 Hofstra Blvd, Hempstead, New York, 11549, United States.

We report a case of a female teenager with gonococcal septic arthritis of the right shoulder that also caused osteomyelitis of the humeral head. Infection with is a frequently diagnosed sexually transmitted infection in the sexually active teenage population and disseminated gonococcal infection (DGI) is the most common systemic manifestation of acute gonorrhea. DGI commonly involves acute arthritis, tenosynovitis and dermatitis with less common complications of endocarditis, hepatitis and meningitis. Read More

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http://dx.doi.org/10.1016/j.idcr.2020.e00875DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7327928PMC

High Mobility and STIs/HIV among Women Informal Cross Border Traders in Southern Mozambique: Exploring Knowledge, Risk Perception, and Sexual Behaviors.

Int J Environ Res Public Health 2020 Jun 30;17(13). Epub 2020 Jun 30.

International Public Health and Biostatistics Unit, Institute of Hygiene and Tropical Medicine, NOVA, University of Lisbon, 1349-008 Lisbon, Portugal.

High circular mobility creates vulnerability and elevates risk for sexually transmitted infections (STIs) including Human Immunodeficiency Virus (HIV). We aim to explore knowledge, perceptions of risk, and sexual behaviors in relation to STIs/HIV, in Mozambican women involved in an informal cross border trade (ICBT) and residing in South Mozambique. A cross-sectional quantitative study, in 200 women cross border traders (WICBT), affiliated to the Association, using a structured, face-to-face questionnaire, was conducted. Read More

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http://dx.doi.org/10.3390/ijerph17134724DOI Listing

Determinants of gonorrhea and syphilis infections among pregnant women attending antenatal clinic at Dilla University Referral Hospital, Ethiopia: Unmatched case-control study.

Womens Health (Lond) 2020 Jan-Dec;16:1745506520940095

School of Public Health, Hawassa University, Hawassa, Ethiopia.

Objective: This study was designed to determine the risk factors associated with gonorrhea and syphilis infections among pregnant women attending antenatal care clinic at Dilla University Referral Hospital.

Method: A hospital-based unmatched case-control study (64 cases and 128 controls) with 1:2 ratios was conducted from 29 January 2018 to 20 June 2018, at the antenatal care clinic of the Dilla University Referral Hospital. Venous blood and vaginal swab were collected to screen for gonorrhea and syphilis. Read More

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http://dx.doi.org/10.1177/1745506520940095DOI Listing

Disseminated gonococcal infection in a patient with paroxysmal nocturnal hemoglobinuria having received ravulizumab and meningococcal vaccine.

J Microbiol Immunol Infect 2020 Jun 30. Epub 2020 Jun 30.

Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan; Department of Tropical Medicine and Parasitology, National Taiwan University College of Medicine, Taipei, Taiwan; Department of Medical Research, China Medical University Hospital, Taichung, Taiwan; China Medical University, Taichung, Taiwan. Electronic address:

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http://dx.doi.org/10.1016/j.jmii.2020.06.013DOI Listing

The Impact of Pre-exposure Prophylaxis for Human Immunodeficiency Virus on Gonorrhea Prevalence.

Bull Math Biol 2020 Jul 1;82(7):85. Epub 2020 Jul 1.

Department of Applied Mathematics, University of Waterloo, 200 University Ave West, Waterloo, ON, N2L 3G1, Canada.

Pre-exposure prophylaxis (PrEP) has been shown to be highly effective in reducing the risk of HIV infection in gay and bisexual men who have sex with men (GbMSM). However, PrEP does not protect against other sexually transmitted infections (STIs). In some populations, PrEP has also led to riskier behavior such as reduced condom usage, with the result that the prevalence of bacterial STIs like gonorrhea has increased. Read More

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http://dx.doi.org/10.1007/s11538-020-00762-7DOI Listing

Changing demography of genital chlamydia, gonorrhea, genital herpes, condyloma and syphilis infections in Japan.

Jpn J Infect Dis 2020 Jun 30. Epub 2020 Jun 30.

National Institute of Infectious Diseases, Japan.

There was epidemiological correlation in time and in space between gonorrhea and genital chlamydia and between condyloma and genital herpes. There was, however, no correlation in other combinations, such as, gonorrhea and condyloma, genital herpes and chlamydia, etc. The annual incidence of gonorrhea and that of genital chlamydia were mono-phasic with a peak in 2005-2006. Read More

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http://dx.doi.org/10.7883/yoken.JJID.2020.005DOI Listing

MYCOPLASMA GENITALIUM AS A CAUSE OF PELVIC INFLAMMATORY DISEASE.

J Pediatr Adolesc Gynecol 2020 Jun 28. Epub 2020 Jun 28.

Department of Pediatrics, Division of Pediatric and Young Women's Gynecology, New York Medical College, Valhalla, NY.

Background: Mycoplasma genitalium is an increasingly recognized cause of pelvic inflammatory disease.

Case: A 17-year-old adolescent female presented with chronic pelvic pain and dysmenorrhea. Testing for Chlamydia trachomatis and Neisseria gonorrhea were negative. Read More

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http://dx.doi.org/10.1016/j.jpag.2020.06.015DOI Listing

Intrauterine Devices in the Context of Gonococcal Infection, Chlamydial Infection, and Pelvic Inflammatory Disease: Not Mutually Exclusive.

J Midwifery Womens Health 2020 Jun 27. Epub 2020 Jun 27.

Egan School of Nursing and Health Studies, Fairfield University, Fairfield, Connecticut.

The use of long-acting reversible contraception, namely, intrauterine device (IUDs) and the subdermal implant, has been recommended to address the high rate of the unintended pregnancy in the United States. IUDs are a safe, highly effective contraceptive method, suitable for most women. The underutilization of IUDs arises in part from the lack of translation of best practices in the clinical setting as well as fears and misperceptions about this contraceptive method held by health care providers and women. Read More

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http://dx.doi.org/10.1111/jmwh.13120DOI Listing

Evaluation of Self-Collection as a Method of Extragenital STI Screening.

Mil Med 2020 Jun 27. Epub 2020 Jun 27.

Department of Infectious Diseases, Brooke Army Medical Center, Fort Sam Houston, TX 78234, USA.

Introduction: The goal of this study is to improve overall screening, detection, and treatment of Neisseria gonorrhea (GC) and Chlamydia trachomatis (CT) at our institution.

Materials And Methods: An observational study with two phases was conducted at a U.S. Read More

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http://dx.doi.org/10.1093/milmed/usaa123DOI Listing

Low HIV incidence among women following sexually transmitted infection does not support national pre-exposure prophylaxis recommendations.

AIDS 2020 Jul;34(9):1429-1431

Public Health-Seattle & King County HIV/STD Program.

: Current United States guidelines recommend that clinicians offer HIV pre-exposure prophylaxis (PrEP) to women with gonorrhea or syphilis. We estimated HIV incidence among women following a syphilis, gonorrhea, or chlamydia diagnosis among women in King County, WA using surveillance data from 2008 to 2018. Among women with diagnosed with gonorrhea and among women diagnosed with chlamydia the estimated HIV incidence rates were 0. Read More

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http://dx.doi.org/10.1097/QAD.0000000000002561DOI Listing

[Rapid testing for sexually transmitted infections].

MMW Fortschr Med 2020 Jun;162(Suppl 2):44-48

Immunschwäche-Ambulanz, Klinik und Poliklinik für Dermatologie, Universitätsklinikum Carl Gustav Carus an der Technischen Universität Dresden, Fetscherstraße 74, D-01307, Dresden, Deutschland.

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http://dx.doi.org/10.1007/s15006-020-0646-xDOI Listing

Epithelial Haven and Autophagy Breakout in Gonococci Infection.

Front Cell Dev Biol 2020 9;8:439. Epub 2020 Jun 9.

Departamento de Genética, Ecologia e Evolução, Instituto de Ciencias Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.

The World Health Organization (WHO) has estimated that in 2016, there were 87 million new cases of gonorrhea. Gonorrhea is caused by the sexually transmitted human-exclusive agent , a Gram-negative diplococcus that causes cervicitis in females and urethritis in males and may lead to more severe complications. Currently, there is no vaccine against . Read More

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http://dx.doi.org/10.3389/fcell.2020.00439DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7295977PMC

Preliminary assessment of antimicrobial activity and acute toxicity of norfloxacin chlorination by-product mixture.

Environ Sci Pollut Res Int 2020 Jun 23. Epub 2020 Jun 23.

Department of Sanitary and Environmental Engineering, Federal University of Minas Gerais (UFMG), Belo Horizonte, Minas Gerais, Brazil.

Among drugs and personal care products, antibiotics arouse interest since they are widely used in human and veterinary medicine and can lead to the development of bacterial resistance. Usually, sewage treatment does not remove most of these compounds. So, these drugs can reach water treatment plants (WTP), where disinfection with chlorine compounds is common. Read More

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http://dx.doi.org/10.1007/s11356-020-09748-3DOI Listing

Balanophora polyandra Griff. prevents dextran sulfate sodium-induced murine experimental colitis via the regulation of NF-κB and NLRP3 inflammasome.

Food Funct 2020 Jun 23. Epub 2020 Jun 23.

College of Medical Science, China Three Gorges University, Yichang, 443002, China. and Third-Grade Pharmacological Laboratory on Chinese Medicine Approved by State Administration of Traditional Chinese Medicine, China Three Gorges University, Yichang, 443002, China and Tumor Microenvironment and Immunotherapy Key Laboratory of Hubei province, China Three Gorges University, Yichang, 443002, China.

Balanophora polyandra Griff. (B. polyandra) is a folk medicine used as an antipyretic, antidote, haemostatic, dressing and haematic tonic, for the treatment of gonorrhea, syphilis, wounds, and the bleeding of the alimentary tract by the local people in China. Read More

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http://dx.doi.org/10.1039/c9fo02494hDOI Listing

Increasing Chlamydia and Gonorrhea Infections among Female Juveniles: The Need for Collaboration to Improve Treatment.

Cureus 2020 Jun 4;12(6):e8446. Epub 2020 Jun 4.

Emergency Medicine, Arrowhead Regional Medical Center, Colton, USA.

Background:  Youth in juvenile detention centers are at a high risk for sexually transmitted disease (STD). The current study assesses the trends of chlamydia and gonorrhea (GC) infections and treatment among females within a single county's juvenile correctional facilities.

Methods: This is a retrospective review of aggregate data of female adolescents between 12 and 18 years old who underwent STD screening from 2009 to 2016 in San Bernardino County. Read More

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http://dx.doi.org/10.7759/cureus.8446DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7301431PMC

Prescription Patterns of Wu Lin San Concentrated Extract Product for Cystitis in Taiwan: A Population-Based Study.

Evid Based Complement Alternat Med 2020 20;2020:2605462. Epub 2020 May 20.

PhD Program in Clinical Drug Development of Herbal Medicine, College of Pharmacy, Taipei Medical University, Taipei, Taiwan.

The indications for the concentrated extract product (CEP) of Wu Lin San (WLS) are urethritis, cystitis, and gonorrhea. In clinical settings, WLS is combined with other CEPs used. However, there are no prescribed guidelines of CEPs in Taiwan. Read More

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http://dx.doi.org/10.1155/2020/2605462DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7256769PMC

Current Perspectives on the Impact of Pre-Exposure Prophylaxis Stigma Regarding Men Who Have Sex with Men in the United States.

Authors:
Patrick D Herron

HIV AIDS (Auckl) 2020 18;12:187-192. Epub 2020 May 18.

Department of Family and Social Medicine, Albert Einstein College of Medicine, Bronx, NY, USA.

Pre-exposure prophylaxis or PrEP is a Food and Drug Administration approved human immunodeficiency virus (HIV) prevention tool that reduces the risk of infection by greater than 90%. While it does not provide protection against other sexually transmittable infections and blood-borne illnesses such as hepatitis C, syphilis, chlamydia, and gonorrhea, it is a highly effective in reducing the risk of transmission of HIV among men who have sex with men. Despite the success of PrEP, there remain barriers to PrEP uptake rooted in stigmatized perspectives shared by health professionals, patients, and community members. Read More

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http://dx.doi.org/10.2147/HIV.S214380DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7244237PMC

Sensitivity, specificity, inclusivity and exclusivity of the updated Aptima Combo 2 assay, which provides detection coverage of the new diagnostic-escape Chlamydia trachomatis variants.

BMC Infect Dis 2020 Jun 16;20(1):419. Epub 2020 Jun 16.

World Health Organization Collaborating Centre for Gonorrhoea and Other Sexually Transmitted Infections (STIs), National Reference Laboratory for STIs, Department of Laboratory Medicine, Clinical Microbiology, Faculty of Medicine and Health, Örebro University, SE-701 85, Örebro, Sweden.

Background: Four new variants of Chlamydia trachomatis (nvCTs), detected in several countries, cause false-negative or equivocal results using the Aptima Combo 2 assay (AC2; Hologic). We evaluated the clinical sensitivity and specificity, as well as the analytical inclusivity and exclusivity of the updated AC2 for the detection of CT and Neisseria gonorrhoeae (NG) on the automated Panther system (Hologic).

Methods: We examined 1004 clinical AC2 samples and 225 analytical samples spiked with phenotypically and/or genetically diverse NG and CT strains, and other potentially cross-reacting microbial species. Read More

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http://dx.doi.org/10.1186/s12879-020-05148-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7298785PMC
June 2020
2.613 Impact Factor

Evaluation of Text Message Reminders to Encourage Retesting for Chlamydia and Gonorrhea Among Female Patients at the Municipal Sexually Transmitted Disease Clinic in Seattle, Washington.

Sex Transm Dis 2020 07;47(7):458-463

From the Department of Epidemiology.

Background: United States guidelines recommend retesting for chlamydia (CT) and gonorrhea (GC) approximately 3 months after treatment, but adherence to these guidelines is poor.

Methods: In May 2016, the municipal sexually transmitted disease (STD) Clinic in Seattle, WA, integrated opt-in short message system (SMS) (text message) retesting reminders for female patients into our clinic's routine electronic intake. Women were asked if they wanted to receive an SMS reminder for retesting for GC/CT in 3 months. Read More

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http://dx.doi.org/10.1097/OLQ.0000000000001184DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7301878PMC

Early sex work initiation and its association with condomless sex and sexually transmitted infections among female sex workers in Iran.

Int J STD AIDS 2020 Jun;31(7):671-679

Department of Epidemiology, Key Populations Program, Center for Public Health and Human Rights, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.

Early sex work initiation among female sex workers (FSWs) increases their vulnerabilities to high-risk sexual practices and sexually transmitted infections (STIs). We examined the association of early sex work with condomless sex indicators, HIV, and other STIs, including human papillomavirus, chlamydia, trichomoniasis, syphilis, and gonorrhea, among FSWs in Iran. We recruited 1347 FSWs from 13 cities in 2015, with 1296 participants (94. Read More

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http://dx.doi.org/10.1177/0956462420913431DOI Listing

Meningococcal disease and sexual transmission: urogenital and anorectal infections and invasive disease due to Neisseria meningitidis.

Lancet 2020 06;395(10240):1865-1877

Immunisation and Countermeasures Division, Public Health England, London, UK.

Neisseria meningitidis is an obligate human commensal bacterium that frequently colonises the upper respiratory tract. Person-to-person transmission occurs via direct contact or through dispersion of respiratory droplets from a carrier of the bacteria, and can lead to invasive meningococcal disease. Rare sporadic cases of meningococcal urogenital and anorectal infections, including urethritis, proctitis, and cervicitis, have been reported, typically following orogenital contact with an oropharyngeal meningococcal carrier. Read More

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http://dx.doi.org/10.1016/S0140-6736(20)30913-2DOI Listing

Lack of STI Treatment Accuracy When Relying on Syndromic Management in an Urgent Care Setting.

Sex Transm Dis 2020 Jun 8. Epub 2020 Jun 8.

UnityPoint Clinic - Waterloo.

Background: Chlamydia and gonorrhea are two of the most common sexually transmitted infections and patients are increasingly seeking care for them in urgent care clinics. Providers often rely on syndromic management due to prolonged test turnaround times which can result in inappropriate treatment.

Methods: This study retrospectively evaluated chlamydia and gonorrhea treatment accuracy of adults, men and women, aged 18 and older in four urgent cares in Northeast Iowa, using standard NAAT in a 6-month timeframe through medical records review. Read More

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http://dx.doi.org/10.1097/OLQ.0000000000001216DOI Listing

Transcriptional control of the gonococcal ompA gene by the MisR/MisS two-component regulatory system.

Sci Rep 2020 Jun 10;10(1):9425. Epub 2020 Jun 10.

Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA, 30032, USA.

Neisseria gonorrhoeae, the causative agent of gonorrhea, is an exclusive human pathogen whose growing antibiotic resistance is causing worldwide concern. The increasing rise of antibiotic resistance expressed by gonococci highlights the need to find alternative approaches to current gonorrhea treatment such as vaccine development or novel therapeutics. The gonococcal OmpA protein was previously identified as a potential vaccine candidate due to its conservation and stable expression amongst strains of Neisseria gonorrhoeae. Read More

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http://dx.doi.org/10.1038/s41598-020-66382-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7286886PMC
June 2020
5.078 Impact Factor

A population-specific optimized GeneXpert pooling algorithm for and to reduce cost of molecular STI screening in resource-limited settings.

J Clin Microbiol 2020 Jun 10. Epub 2020 Jun 10.

Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA 30322.

The sexually transmitted infections (STIs) chlamydia (CT) and gonorrhea (NG) are often asymptomatic in women and undetected by syndromic management, leading to complications such as pelvic inflammatory disease, infertility, and ectopic pregnancy. Molecular testing, such as the GeneXpert CT/NG assay, is highly sensitive, but cost restraints preclude implementation of these technologies in resource-limited settings. Pooled testing is one strategy to reduce the cost-per-sample, but the extent of savings depends on disease prevalence. Read More

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http://dx.doi.org/10.1128/JCM.00176-20DOI Listing

Antimicrobial Resistance of Neisseria Gonorrhoeae in a Newly Implemented Surveillance Program in Uganda: Surveillance Report.

JMIR Public Health Surveill 2020 Jun 10;6(2):e17009. Epub 2020 Jun 10.

Division of Infectious Diseases, Johns Hopkins School of Medicine, Baltimore, MD, United States.

Background: Neisseria gonorrhoeae (commonly known as gonorrhea) has developed resistance to all first-line therapy in Southeast Asia. East Africa has historically had absent or rudimentary gonorrhea surveillance programs and, while the existence of antimicrobial-resistant gonorrhea is recognized, the extent of its resistance is largely unknown. In 2016, the World Health Organization's Enhanced Gonococcal Antimicrobial Surveillance Program (EGASP) was initiated in Uganda to monitor resistance trends. Read More

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http://dx.doi.org/10.2196/17009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7315362PMC

, and among women with genitourinary infection and pregnancy-related complications in Tehran: A cross-sectional study.

Int J STD AIDS 2020 Jul 10;31(8):773-780. Epub 2020 Jun 10.

Faculty of Medicine, Centre for Clinical Research, The University of Queensland, Herston, Queensland, Australia.

The present study investigates the prevalence of (CT), (NG), and (TV) among women with genitourinary infection and pregnancy-related complications in Tehran. It also evaluates the demographic information, symptoms, and sequelae. Endocervical samples were obtained over a period of eight months from 360 women including 180 symptomatic patients and 180 patients with pregnancy-related complications and infertility. Read More

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http://dx.doi.org/10.1177/0956462420922462DOI Listing

Budgeting for comprehensive sexual and reproductive health and rights under universal health coverage.

Sex Reprod Health Matters 2020 Jun 9:1-26. Epub 2020 Jun 9.

Senior Research Associate, Guttmacher Institute, New York, NY, USA.

Achieving universal health coverage (UHC) for sexual and reproductive health (SRH) requires informed budgeting that is aligned with UHC objectives. We draw data from , to provide critical new country-level and regional, intervention-specific costs for provision of SRH services. AIU-2019 is a cost-outcomes analysis, undertaken from the health system perspective, which estimates the costs and impacts of offering SRH care in low- and middle-income countries (LMICs). Read More

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http://dx.doi.org/10.1080/26410397.2020.1779631DOI Listing

Trends and Characteristics of Sexually Transmitted Infections During Pregnancy: United States, 2016-2018.

Natl Vital Stat Rep 2020 Mar;69(3):1-11

Objectives-This report presents data on recent trends for three sexually transmitted infections (STIs)-chlamydia, gonorrhea, and syphilis-reported among women giving birth in the United States from 2016 through 2018, and rates by selected characteristics for 2018. Methods-Data are from birth certificates and are based on 100% of births registered in the United States for 2016, 2017, and 2018. Birth certificate data on infections during pregnancy are recommended to be collected from the mother's medical records (1). Read More

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Point-by-Point Progress: Gonorrhea Point of Care Tests.

Expert Rev Mol Diagn 2020 Jun 30:1-11. Epub 2020 Jun 30.

Division of Infectious Diseases, Department of Medicine, Johns Hopkins University , Baltimore, Maryland, USA.

Introduction: Point-of-care (POC) tests for (Ng) are urgently needed to control the gonorrhea epidemic, so patients can receive immediate diagnoses and treatment. While the advent of nucleic acid amplification tests (NAATs) has improved the accuracy of Ng identification, very few POC assays are able to provide results of such tests at the clinical visit. Additionally, antimicrobial resistance (AMR) presents a unique treatment challenge for Ng. Read More

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http://dx.doi.org/10.1080/14737159.2020.1778467DOI Listing

Stigma Surrounding Sexually Transmitted Infections among Medical Students in Germany.

J Sex Res 2020 Jun 5:1-8. Epub 2020 Jun 5.

Department of Psychiatry and Psychotherapy, University Medical Center Mainz.

Stigmatization by health care professionals leads to decreased help-seeking behaviors in those being stigmatized. Prejudicial attitudes are especially pronounced concerning sexually transmitted infections (STIs), which is crucial in light of rising prevalence rates of STIs in recent years. We aimed to examine stigmatization against patients with sexually versus non-sexually transmitted infections among medical students in Germany. Read More

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http://dx.doi.org/10.1080/00224499.2020.1763238DOI Listing

Neisseria gonorrhoeae Septic Arthritis with Contiguous Infection Consistent with Acute Osteomyelitis.

Sex Transm Dis 2020 Jun 2. Epub 2020 Jun 2.

Department of Internal Medicine, Section on Infectious Diseases.

Neisseria gonorrhoeae osteomyelitis is a rare complication of disseminated gonococcal infection (DGI). As the rates of N. gonorrhea continue to increase in the U. Read More

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http://dx.doi.org/10.1097/OLQ.0000000000001212DOI Listing

Interest in Taking HIV Pre-exposure Prophylaxis Is Associated with Behavioral Risk Indicators and Self-Perceived HIV Risk Among Men Who Have Sex with Men Attending HIV Testing Venues in Sweden.

Arch Sex Behav 2020 Aug 3;49(6):2165-2177. Epub 2020 Jun 3.

Clinical Infection Medicine, Department of Translational Medicine, Lund University, Malmö, Sweden.

This study explored factors associated with interest in taking PrEP among men who have sex with men (MSM) attending HIV testing venues in Sweden. Data from 658 HIV-negative respondents, surveyed by a questionnaire at six sites, were analyzed descriptively and by univariable and multivariable logistic regression. A total of 453 (68. Read More

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http://dx.doi.org/10.1007/s10508-020-01740-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7316853PMC

Fifteen years of a nationwide culture collection of Neisseria gonorrhoeae antimicrobial resistance in Portugal.

Eur J Clin Microbiol Infect Dis 2020 Jun 3. Epub 2020 Jun 3.

National Reference Laboratory for Sexually Transmitted Infections, Department of Infectious Diseases, National Institute of Health, Avenida Padre Cruz, 1649-016, Lisbon, Portugal.

Neisseria gonorrhoeae antimicrobial resistance (AMR) and gonorrhea disease burden remain major public health concerns worldwide. To contribute to the supranational demands to monitor and manage the spread of antimicrobial-resistant N. gonorrhoeae, the Portuguese NIH promoted the creation of the National Laboratory Network for Neisseria gonorrhoeae Collection (PTGonoNet). Read More

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http://dx.doi.org/10.1007/s10096-020-03907-7DOI Listing
June 2020
2.668 Impact Factor

Fracking and risky sexual activity.

J Health Econ 2020 May 15;72:102322. Epub 2020 May 15.

Montana State University, United States.

This paper examines the impact of the U.S. fracking boom on local STI transmission rates and prostitution activity as measured by online prostitution review counts. Read More

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http://dx.doi.org/10.1016/j.jhealeco.2020.102322DOI Listing

Antimicrobial susceptibility profile of Gonococcal isolates obtained from men presenting with urethral discharge in Addis Ababa, Ethiopia: Implications for national syndromic treatment guideline.

PLoS One 2020 1;15(6):e0233753. Epub 2020 Jun 1.

Clinical Bacteriology and Mycology, Ethiopian Public Health Institute Ethiopia, Addis Ababa, Ethiopia.

Background: Neisseria gonorrhoeae (gonococcus) is the etiologic agent for the sexually transmitted Infection gonorrhea, a disease with a significant global public health impact. The treatment regimen for gonorrhea has been changed frequently over the past few decades due to the organism's propensity for developing antibiotic resistance. This study investigated antimicrobial susceptibility patterns of quinolones, third-generation cephalosporin, and other relevant antimicrobials found in N. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0233753PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7263590PMC

Age specific evaluation of sexual behavior, STI knowledge and infection among asymptomatic adolescents and young adults.

J Infect Public Health 2020 May 26. Epub 2020 May 26.

Walk In Ruhr (WIR), Center for Sexual Health and Medicine, Bochum, Germany; Interdisciplinary Immunological Outpatient Clinic, Center for Sexual Health and Medicine, Department of Dermatology, Venereology and Allergology, Ruhr Universität Bochum, Germany. Electronic address:

Objectives: Adolescents and young adults account for 50% of new infections with sexually transmitted infection (STI), while representing only 25% of the sexually active population. An evaluation of sexual behavior, STI knowledge and infection among youth of different age groups is relevant to formulate effective sexual health strategies.

Methods: In this monocentric, open, prospective cross-sectional study, 268 asymptomatic subjects (14-30 years) were partitioned into three cohorts I: 14-19 (n=42), II: 20-25 (n=147) and III: 25-30 (n=79) years. Read More

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http://dx.doi.org/10.1016/j.jiph.2020.04.005DOI Listing

Cryo-EM Structures of a Gonococcal Multidrug Efflux Pump Illuminate a Mechanism of Drug Recognition and Resistance.

mBio 2020 May 26;11(3). Epub 2020 May 26.

Department of Pharmacology, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA

is an obligate human pathogen and causative agent of the sexually transmitted infection (STI) gonorrhea. The most predominant and clinically important multidrug efflux system in is the ultiple ransferrable esistance (Mtr) pump, which mediates resistance to a number of different classes of structurally diverse antimicrobial agents, including clinically used antibiotics (e.g. Read More

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http://dx.doi.org/10.1128/mBio.00996-20DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7251214PMC

Molecular Insight into TdfH-Mediated Zinc Piracy from Human Calprotectin by Neisseria gonorrhoeae.

mBio 2020 May 26;11(3). Epub 2020 May 26.

Center for Translational Immunology, Institute for Biomedical Sciences, Georgia State University, Atlanta, Georgia, USA

, responsible for the sexually transmitted infection gonorrhea, is an obligate human pathogen exquisitely adapted for survival on mucosal surfaces of humans. This host-pathogen relationship has resulted in evolution by of pathways that enable the use of host metalloproteins as required nutrients through the deployment of outer membrane-bound TonB-dependent transporters (TdTs). Recently, a TdT called TdfH was implicated in binding to calprotectin (CP) and in removal of the bound zinc (Zn), enabling gonococcal growth. Read More

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http://dx.doi.org/10.1128/mBio.00949-20DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7251212PMC

A Need for Standardization of the Diagnosis and Treatment of Pelvic Inflammatory Disease: Pilot Study in an Outpatient Clinic in Quito, Ecuador.

Infect Dis Obstet Gynecol 2020 9;2020:5423080. Epub 2020 May 9.

Instituto de Investigaciones en Biomedicina, Universidad San Francisco de Quito, 17-12-841 Quito, Ecuador.

Background: Pelvic inflammatory disease (PID) diagnosis is often challenging as well as its treatment. This study sought to characterize the diagnostic and therapeutic trend among physicians at the outpatient level, in Quito, Ecuador, where currently no nationwide screening or specific clinical guideline has been implemented on PID or its main microbiological agents.

Methods: A retrospective analysis of medical records with pelvic inflammatory disease diagnosis in an outpatient clinic was performed. Read More

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http://dx.doi.org/10.1155/2020/5423080DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7232719PMC

[Analysis on infection status and related factors in outpatients of sexually transmitted diseases in Shenzhen].

Zhonghua Liu Xing Bing Xue Za Zhi 2020 May;41(5):743-746

Institute of Dermatology and Hospital for Skin Diseases, Chinese Academy of Medical Sciences and Peking Union Medical Collage, Nanjing 210042, China; National Center for STD Control, Chinese Center for Disease Control and Prevention, Nanjing 210042, China.

To understand the prevalence of (NG) infection and related factors in outpatients of sexually transmitted disease (STD) in Shenzhen and provide scientific evidence for targeted intervention. A cross-sectional study was conducted in STD outpatients who were aged 18-49 years, had had sexual intercourse, had not received antibiotics in the last 2 weeks and sought medical cares in 22 medical institutions in 6 districts of Shenzhen from 15 April, 2018 to 16 May, 2018, their basic information and urine samples were collected, and NG in urine sample was detected by nucleic acid amplification test. Logistic regression analysis was conducted to identify the related factors for NG infection. Read More

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http://dx.doi.org/10.3760/cma.j.cn112338-20190711-00513DOI Listing

Test of cure study: a feasibility study to estimate the time to test of cure (TOC) for and infections.

Sex Transm Infect 2020 May 23. Epub 2020 May 23.

Sexually Transmitted Bacteria Reference Unit, Public Health England, London, UK.

Objectives: Test of cure (TOC) for (NG) and (CT) infection is an important tool in the public health management of STIs. However, there are limited data about the optimal time to perform TOC using nucleic acid amplification tests (NAATs) for NG and CT infections. A study was performed to assess the feasibility of a larger study to determine the optimal time to TOC using NAATS. Read More

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http://dx.doi.org/10.1136/sextrans-2019-054302DOI Listing

Adolescent Trichomonas vaginalis in a High-burdened Region of the Southern United States.

Sex Transm Dis 2020 07;47(7):499-502

Department of Pediatrics, Division of Developmental-Behavioral Pediatrics, Prisma Health Upstate, Greenville, SC.

Background: We evaluated the clinical management and risk factors for Trichomonas vaginalis-positive adolescents in upstate South Carolina.

Methods: An Epic electronic medical record report was generated to identify any physician-ordered T. vaginalis test from February 2016 to December 2017 for patients aged 12 to 18 years within the Prisma Health Upstate system. Read More

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http://dx.doi.org/10.1097/OLQ.0000000000001186DOI Listing

EVA technology and proteomics: a two-pronged attack on Cultural Heritage.

J Proteome Res 2020 May 22. Epub 2020 May 22.

A novel way for exploring the world Cultural Heritage in the absence of damage or contamination of the items under investigation is here reported, called the EVA technique. It is based on films of ethylene vinyl acetate (EVA) impregnated with strong anion and cation exchangers, admixed with hydrophobic resins, C8 and C18. When in contact with any surface these films can harvest nano-moles of macromolecules (proteins and DNA) as well as metabolites, which can then be identified by standard instrumentation. Read More

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http://dx.doi.org/10.1021/acs.jproteome.0c00080DOI Listing

Transcriptomic Data Sets To Determine Gene Expression Changes Mediated by the Presence of PBT2 in Growth Medium of Multidrug-Resistant Neisseria gonorrhoeae WHO Z.

Microbiol Resour Announc 2020 May 21;9(21). Epub 2020 May 21.

Institute for Glycomics, Griffith University, Gold Coast, QLD, Australia

causes the sexually transmitted infection gonorrhea. High-coverage (∼3,300-fold) transcriptome sequencing data have been collected from multidrug-resistant strain WHO Z grown in the presence and absence of PBT2. Read More

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http://dx.doi.org/10.1128/MRA.00283-20DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7242666PMC

The Use of Gentamicin for Treatment of Urogenital and Extragenital Gonorrhea: A Systematic Review of Efficacy Data.

Ann Pharmacother 2020 May 21:1060028020927057. Epub 2020 May 21.

University of Otago, Dunedin, New Zealand.

To evaluate clinical efficacy data for gentamicin in the treatment of gonorrhea. A keyword search of PubMed (1966 to April 2020), EMBASE (1947 to April 2020), and International Pharmaceutical Abstracts (1970 to April 2020) was conducted. The electronic search was supplemented with manual screening of references from identified articles and a search of ClinicalTrials. Read More

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http://dx.doi.org/10.1177/1060028020927057DOI Listing

Sexually Transmitted and Blood-Borne Infections in Pregnant Women and Adverse Pregnancy Outcomes.

J Obstet Gynaecol Can 2020 May 14. Epub 2020 May 14.

Centre hospitalier universitaire Sainte-Justine, Montréal, QC; École de santé publique de l'Université de Montréal (ESPUM), Montréal, QC; Department of Obstetrics and Gynaecology, Faculty of Medicine, Université de Montréal, Montréal, QC. Electronic address:

Objectives: To analyze risk factors for the presence of sexually transmitted and blood-borne infections (STBBIs) in pregnancy and to determine whether pregnant women with STBBIs are more likely to experience adverse pregnancy outcomes.

Methods: This retrospective cohort study involved analyzing the electronic records of 3460 pregnant women followed at Sainte-Justine Hospital in Montréal, Québec, between March 2017 and January 2019. An outcome is defined as a pregnancy where the woman has at least one positive laboratory result for chlamydia, gonorrhea, syphilis, hepatitis B, or hepatitis C (i. Read More

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http://dx.doi.org/10.1016/j.jogc.2020.01.023DOI Listing