19,135 results match your criteria Gonococcal Infections


The serogroup B meningococcal vaccine Bexsero elicits antibodies to Neisseria gonorrhoeae.

Clin Infect Dis 2018 Dec 14. Epub 2018 Dec 14.

Institute for Glycomics, Griffith University, Gold Coast, Australia.

Background: Neisseria gonorrhoeae and Neisseria meningitidis are closely related bacteria that cause a significant global burden of disease. Control of gonorrhoea is becoming increasingly difficult due to widespread antibiotic resistance. While vaccines are routinely used for N. Read More

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December 2018

Individual and sexual network predictors of HIV incidence among men who have sex with men in Nigeria.

J Acquir Immune Defic Syndr 2018 Dec 10. Epub 2018 Dec 10.

Institute of Human Virology, University of Maryland School of Medicine, Baltimore, MD, USA.

Background: To date, HIV incidence studies among men who have sex with men (MSM) across sub-Saharan Africa have focused on studying sexual risk practices with less focus on sexual networks.

Setting: TRUST/RV368 conducted in Abuja and Lagos, Nigeria recruited MSM using respondent driven sampling (RDS) and followed HIV negative men for incident infection over 4 years.

Methods: Four-hundred forty-one HIV-uninfected MSM underwent a parallel rapid HIV testing algorithm every 3 months for up to 18 months. Read More

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December 2018
1 Read

HIV DIAGNOSIS FOLLOWING A SYPHILIS, GONORRHEA, OR REPEAT DIAGNOSIS AMONG MALES INCLUDING NON-MSM: WHAT IS THE INCIDENCE?

Sex Transm Dis 2018 Dec 13. Epub 2018 Dec 13.

Center for Child and Community Health Research (CCHR), Department of Pediatrics, Johns Hopkins School of Medicine, Baltimore, MD, USA.

Background: The release of the first drug for HIV pre-exposure prophylaxis (PrEP) in 2012 marked the beginning of a new era of HIV prevention. Although PrEP is highly efficacious, identifying and ultimately increasing uptake among the highest risk male subgroups remains a challenge.

Methods: Public health surveillance data from 2009-2016 was used to evaluate the risk of an HIV diagnosis following a syphilis (i. Read More

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December 2018
2 Reads

Rebound in Sexually Transmitted Infections Following the Success of Antiretrovirals for HIV/AIDS.

AIDS Rev 2018 ;20(4):187-204

Sexually Transmitted infections Unit, Centro Sanitario Sandoval. Madrid, Spain.

Nearly 1 million people become infected every day with any of the four major curable sexually transmitted infections (STIs), namely trichomoniasis, chlamydia, gonorrhea, and syphilis. Despite huge global incidence, STIs remain as neglected diseases. The success of antiretrovirals for halting progression to AIDS in HIV-infected individuals and for stopping HIV transmission to uninfected contacts, either as pre- or post-exposure -prophylaxis, has to lead to increased risky sexual behaviors through risk compensation. Read More

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January 2018

Resistance profile of clinically relevant bacterial isolates against fluoroquinolone in Ethiopia: a systematic review and meta-analysis.

BMC Pharmacol Toxicol 2018 Dec 12;19(1):86. Epub 2018 Dec 12.

Department of Medical Laboratory Sciences, College of Health and Medical Sciences, Haramaya University, P.O.Box 235, Harar, Ethiopia.

Background: Fluoroquinolones are among the most frequently utilized antibacterial agents in developing countries like Ethiopia. Ciprofloxacin has become the most prescribed drug within this class and remains as one of the top three antibacterial agents prescribed in Ethiopia. However, several studies indicated that there is a gradual increase of antibacterial resistance. Read More

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December 2018
9 Reads

Pathogenesis of and the Host Defense in Ascending Infections of Human Fallopian Tube.

Front Immunol 2018 21;9:2710. Epub 2018 Nov 21.

Department of Medical Microbiology and Immunology, University of Wisconsin-Madison, Madison, WI, United States.

is an obligate human pathogen that causes mucosal surface infections of male and female reproductive tracts, pharynx, rectum, and conjunctiva. Asymptomatic or unnoticed infections in the lower reproductive tract of women can lead to serious, long-term consequences if these infections ascend into the fallopian tube. The damage caused by gonococcal infection and the subsequent inflammatory response produce the condition known as pelvic inflammatory disease (PID). Read More

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November 2018
1 Read

Antimicrobial Consumption and Susceptibility of : A Global Ecological Analysis.

Front Med (Lausanne) 2018 27;5:329. Epub 2018 Nov 27.

Department of Reproductive Health and Research, World Health Organization, Geneva, Switzerland.

The reasons why antimicrobial resistance in has emerged explosively in certain populations but not others are poorly understood. We hypothesized that population level consumption of antimicrobials plays a role. Using susceptibility data from the World Health Organizations Global Gonococcal Antimicrobial Surveillance Programme and antimicrobial consumption data from the IMS Health MIDAS database we built linear regression models with country-level cephalosporin, macrolide, and fluoroquinolone consumption (standard doses/1,000 population/year) as the explanatory variable and 1-year lagged ceftriaxone, azithromycin, and ciprofloxacin resistance as the outcome variables. Read More

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November 2018

Lipid-Modified Azurin of Is Not Surface Exposed and Does Not Interact With the Nitrite Reductase AniA.

Front Microbiol 2018 27;9:2915. Epub 2018 Nov 27.

Department of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, Corvallis, OR, United States.

Lipid-modified cupredoxin azurin (Laz) is involved in electron transport in and proposed to act as an electron donor to the surface-displayed nitrite reductase AniA. We identified Laz in cell envelopes and naturally elaborated membrane vesicles in proteomic investigations focused on discovering new vaccine and therapeutic targets for this increasingly difficult to treat pathogen. Its surface exposure in suggested Laz could be a vaccine candidate for . Read More

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November 2018

[Anual Report Epidemiology of gonorrohea (CIE 10: A54)].

Authors:
Karen Cáceres

Rev Chilena Infectol 2018 Aug;35(4):403-412

Departamento de Epidemiología, División de Planificación Sanitaria, Ministerio de Salud de Chile, Chile.

Gonorrhea is produced by the bacterium Neisseria gonorrhoeae, which is capable of infecting different types of mucous membranes depending on sexual practices. It is located preferably in the man's urethra and in the woman's cervix, also in the rectum and pharynx. Its main form of transmission is through unprotected sex and, occasionally, through the birth canal in newborns. Read More

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Contraceptive use and the risk of sexually transmitted infection: systematic review and current perspectives.

Open Access J Contracept 2018 12;9:91-112. Epub 2018 Nov 12.

Global Health, Population and Nutrition, FHI 360, Durham, NC, USA,

Purpose: Evidence on the association between contraceptive use and risk of sexually transmitted infections (STIs) and bacterial vaginosis (BV) is lacking, with few prospective studies. We systematically reviewed the last 10 years' evidence on the association between contraception and STI/BV, building on the most recent systematic reviews published in 2006 and 2009.

Methods: We searched the MEDLINE and POPLINE databases for peer-reviewed articles p ublished between January 1, 2008 and January 31, 2018 reporting prospective studies that assessed the association between contraceptive use and incident STI and/or incident or recurrent BV. Read More

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November 2018
2 Reads

Is the Current Classification of Urethritis as Gonococcal or Nongonoccal Becoming Obsolete?

Authors:
V M Leis-Dosil

Actas Dermosifiliogr 2018 Nov 28. Epub 2018 Nov 28.

Servicio de Dermatología, Hospital Universitario Infanta Sofía, San Sebastián de los Reyes, Madrid, España. Electronic address:

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November 2018
1 Read

Assessing uncertainty in an anatomical site-specific gonococcal infection transmission model of men who have sex with men.

Sex Transm Dis 2018 Dec 3. Epub 2018 Dec 3.

Division of STD Prevention, Centers for Disease Control and Prevention Department of Medicine, Beth Israel Deaconess Medical Center/Harvard Medical School and The Fenway Institute, Fenway Health Division of STD Prevention, Centers for Disease Control and Prevention Theoretical Biology and Biophysics Group, Los Alamos National Laboratory.

Background: Increased gonorrhea detection highlights the need for additional prevention efforts. Gonorrhea may only be acquired when there is contact between infected and uninfected anatomical sites. With three sites of infection this leads to seven plausible routes of MSM transmission: urethra-to-rectum, rectum-to-urethra, urethra-to-oropharynx, rectum-to-oropharynx, oropharynx-to-urethra, oropharynx-to-rectum, and oropharynx-to-oropharynx. Read More

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December 2018
2 Reads

The MtrCDE Efflux Pump Contributes to Survival of From Human Neutrophils and Their Antimicrobial Components.

Front Microbiol 2018 20;9:2688. Epub 2018 Nov 20.

Department of Microbiology, Immunology, and Cancer Biology, University of Virginia, Charlottesville, VA, United States.

The mucosal inflammatory response to (Gc) is characterized by recruitment of neutrophils to the site of infection. Gc survives exposure to neutrophils by limiting the ability of neutrophils to make antimicrobial products and by expressing factors that defend against these products. The multiple transferable resistance (Mtr) system is a tripartite efflux pump, comprised of the inner membrane MtrD, the periplasmic attachment protein MtrC, and the outer membrane channel MtrE. Read More

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November 2018
1 Read

Antimicrobial resistance prediction and phylogenetic analysis of Neisseria gonorrhoeae isolates using the Oxford Nanopore MinION sequencer.

Sci Rep 2018 Dec 4;8(1):17596. Epub 2018 Dec 4.

WHO Collaborating Centre for Gonorrhoea and other Sexually Transmitted Infections, Department of Laboratory Medicine, Clinical Microbiology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden.

Antimicrobial resistance (AMR) in Neisseria gonorrhoeae is common, compromising gonorrhoea treatment internationally. Rapid characterisation of AMR strains could ensure appropriate and personalised treatment, and support identification and investigation of gonorrhoea outbreaks in nearly real-time. Whole-genome sequencing is ideal for investigation of emergence and dissemination of AMR determinants, predicting AMR, in the gonococcal population and spread of AMR strains in the human population. Read More

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December 2018
1 Read

Gonorrhea and syphilis co-infection and related risk factors in HIV patients from Shiraz, South of Iran.

Caspian J Intern Med 2018 ;9(4):397-402

Department of Bacteriology and Virology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.

Background: and as an obligate human pathogen are two common causes of sexually transmitted diseases (STDs). The present study aimed to determine the prevalence of and among human immunodeficiency virus (HIV) patients in the southwest Iran.

Methods: This retrospective study was performed from 2004 to 2013, on HIV patients who were tested for detection of gonorrhea and syphilis infection at Shiraz HIV/AIDS Research Center. Read More

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January 2018
2 Reads

The role of gonococcal Neisserial surface protein A (NspA) in serum resistance and comparison of its factor H binding properties with that of its meningococcal counterpart.

Infect Immun 2018 Dec 3. Epub 2018 Dec 3.

Department of Medicine, Division of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, MA 01605.

the causative agent of gonorrhea, has evolved several mechanisms to subvert complement, including binding of the complement inhibitor factor H (FH). We previously reported FH binding to independently of lipooligosaccharide (LOS) sialylation. Here we report that Factor H-like protein 1 (FHL-1), which contains FH domains 1 through 7 and possesses complement inhibitory activity, also binds to The ligand for both FH and FHL-1 was identified as Neisserial surface protein A (NspA), which has previously been identified as a ligand for these molecules on As with -NspA, NspA bound FH/FHL-1 through FH domains 6 and 7. Read More

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December 2018
1 Read
3.731 Impact Factor

PBP3 and PBP4 facilitate NOD1 agonist peptidoglycan fragment release and survival in stationary phase.

Infect Immun 2018 Dec 3. Epub 2018 Dec 3.

Department of Medical Microbiology and Immunology, University of Wisconsin-Madison, Madison, Wisconsin, USA

releases peptidoglycan fragments during growth, and these molecules induce an inflammatory response in the human host. The proinflammatory molecules include peptidoglycan monomers, peptidoglycan dimers, and free peptides. These molecules can be released by the actions of lytic transglycosylases or an amidase. Read More

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December 2018
1 Read

Stably high azithromycin resistance and decreasing ceftriaxone susceptibility in Neisseria gonorrhoeae in 25 European countries, 2016.

BMC Infect Dis 2018 Dec 3;18(1):609. Epub 2018 Dec 3.

WHO Collaborating Centre for Gonorrhea and other STIs, Örebro University, Örebro, Sweden.

Background: The European Gonococcal Antimicrobial Surveillance Programme (Euro-GASP) performs annual sentinel surveillance of Neisseria gonorrhoeae susceptibility to therapeutically relevant antimicrobials across the European Union/European Economic Area (EU/EEA). We present the Euro-GASP results from 2016 (25 countries), linked to patient epidemiological data, and compared with data from previous years.

Methods: Agar dilution and minimum inhibitory concentration (MIC) gradient strip methodologies were used to determine the antimicrobial susceptibility (using EUCAST breakpoints) of 2660 N. Read More

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December 2018
1 Read

Mechanistic Basis for Decreased Antimicrobial Susceptibility in a Clinical Isolate of Neisseria gonorrhoeae Possessing a Mosaic-Like Efflux Pump Locus.

MBio 2018 Nov 27;9(6). Epub 2018 Nov 27.

Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia, USA

Recent reports suggest that mosaic-like sequences within the (ultiple ransferable esistance) efflux pump locus of , likely originating from commensal sp. by transformation, can increase the ability of gonococci to resist structurally diverse antimicrobials. Thus, acquisition of numerous nucleotide changes within the gene encoding the transcriptional repressor (MtrR) of the efflux pump-encoding operon or overlapping promoter region for both along with those that cause amino acid changes in the MtrD transporter protein were recently reported to decrease gonococcal susceptibility to numerous antimicrobials, including azithromycin (Azi) (C. Read More

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November 2018
1 Read

Multidrug-resistant isolate, belonging to the internationally spreading Japanese FC428 clone, with ceftriaxone resistance and intermediate resistance to azithromycin, Ireland, August 2018.

Euro Surveill 2018 Nov;23(47)

Authors contributed equally to the work and share joint authorship.

We describe a multidrug-resistant urethritis case with ceftriaxone resistance and azithromycin intermediate resistance in a heterosexual man in Ireland, August 2018. Whole-genome sequencing showed that the isolate IR72 belongs to the internationally spreading multidrug-resistant ceftriaxone-resistant FC428 clade, initially described in Japan in 2015. IR72 was assigned MSLT ST1903, NG-MAST ST17842 and NG-STAR type 1133, including the ceftriaxone resistance-mediating 60. Read More

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November 2018
1 Read

Reaching key populations through key venues: Insights from the Jamaica HIV Prevention Program.

PLoS One 2018 26;13(11):e0206962. Epub 2018 Nov 26.

Department of Medicine, University of North Carolina, North Carolina, United States of America.

Introduction: HIV prevention strategies often include outreach to female sex workers at social venues identified as places where people meet new sexual partners. Patrons and staff at these venues may include female sex workers, their clients, as well as others who have high rates of new sexual partnerships. Few studies have compared HIV/STI among venue-based and general populations, across types of venues, or by sub-group of the venue population. Read More

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November 2018
6 Reads

Polymerase Chain Reaction Assay Using the Restriction Fragment Length Polymorphism Technique in the Detection of Prosthetic Joint Infections: A Multi-Centered Study.

J Arthroplasty 2018 Oct 25. Epub 2018 Oct 25.

Department of Molecular Pathology, National Research Institute of Tuberculosis and Lung Diseases, Shahid Behshti University of Medical Sciences, Tehran, Iran; Department of Molecular Biology, Dr. Khosroshahi's Pathobiology Laboratory, Tehran, Iran.

Background: PCR-RFLP (polymerase chain reaction-restriction fragment length polymorphism) techniques have been used for the diagnosis of bacteria in some infections. In this study, we aimed to evaluate the diagnostic accuracy of PCR for the diagnosis of prosthetic joint infections (PJI) and to identify isolated microorganisms, using the RFLP method.

Methods: During January 2015 to January 2018, patients who were suspected of having PJI after arthroplasty surgery or were candidates for revision surgery due to loosening of implant entered the study. Read More

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October 2018
2 Reads

Epidemiology and current control of sexually transmitted infections. The role of STI clinics.

Enferm Infecc Microbiol Clin 2018 Nov 19. Epub 2018 Nov 19.

Servicio Enfermedades Infecciosas, OSI Bilbao-Basurto, Osakidetza, Grupo de estudio de ITS (GeITS) de la SEIMC, Instituto de Investigación Biocruces Bizkaia, Bizkaia, España. Electronic address:

The burden of disease from sexually transmitted infections (STI) undermines sexual and reproductive health and the health of newborn infants. The presence of some STI facilitates the transmission of others, such as HIV, and cause cellular changes that precede some types of cancer. For all these reasons STIs are a first order uncontrolled public health problem. Read More

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November 2018
6 Reads

In vitro activity of ceftazidime-avibactam, ceftolozane-tazobactam, and other comparable agents against clinically important Gram-negative bacilli: results from the 2017 Surveillance of Multicenter Antimicrobial Resistance in Taiwan (SMART).

Infect Drug Resist 2018 26;11:1983-1992. Epub 2018 Oct 26.

Department of Laboratory Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan.

Objectives: We investigated the in vitro antimicrobial susceptibilities of clinically important Gram-negative bacteria (GNB) from 16 major teaching hospitals in Taiwan in 2017.

Materials And Methods: (n=686) and bloodstream isolates (n=673), non-typhoid (NTS; n=221) from various sources, species (n=21) from fecal samples, and (n=129) from the genitourinary tract were collected. Antibiotic minimum inhibitory concentrations (MICs) were determined using the broth microdilution method. Read More

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October 2018
5 Reads

Neonatal Conjunctivitis Caused by Neisseria cinerea: A Case of Mistaken Identity.

J Pediatric Infect Dis Soc 2018 Nov 21. Epub 2018 Nov 21.

Division of Pediatric Infectious Diseases, Department of Pediatrics, NYU Winthrop Hospital, Mineola, New York.

We report a case of a 3-day-old boy with Neisseria cinerea conjunctivitis, originally misidentified as Neisseria gonorrhoeae conjunctivitis. Neonates are at increased risk for disseminated gonococcal infection, and physicians should be cognizant of N cinerea and its potential to be mistaken for N gonorrhoeae. Read More

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November 2018
3 Reads

Establishment of a gonococcal antimicrobial surveillance programme (GASP), in accordance with WHO standards, in Côte d'Ivoire, Western Africa, 2014-2017.

Sex Transm Dis 2018 Nov 19. Epub 2018 Nov 19.

World Health Organization Collaborating Centre for Gonorrhoea and other STIs, Department of Laboratory Medicine, Microbiology, Örebro University Hospital, Örebro, Sweden.

Background: Antimicrobial resistance (AMR) in Neisseria gonorrhoeae is compromising the treatment of gonorrhea globally. Recent AMR data are extremely limited in Africa, and mainly totally lacking in Western Africa including Côte d'Ivoire. This study i) established a quality-assured gonococcal antimicrobial surveillance programme (GASP), according to WHO quality criteria, ii) investigated the AMR to eight therapeutic antimicrobials in gonococcal isolates from 2014 to 2017, and iii) provided evidence for updating the national STD syndromic management guidelines in Côte d'Ivoire. Read More

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November 2018
8 Reads

Severe Disseminated Gonococcal Infection with Polyarticular Gout: Two Cases in Older Travelers.

Am J Trop Med Hyg 2018 Nov 19. Epub 2018 Nov 19.

Global and Tropical Health Division, Menzies School of Health Research, Darwin, Australia.

Two male travelers with histories of gout and hazardous alcohol consumption, presented with a triad of severe culture-positive disseminated gonococcal infection, crystal-positive polyarticular gout, and gonococcal soft tissue collections, following unprotected sexual contact in The Philippines. Both men initially attributed symptoms to gout, since their usual joints were affected, but clinical deterioration occurred with self-administration of anti-inflammatory agents alone. The clinical courses were severe and protracted, requiring aggressive management of infection with prolonged intravenous antimicrobials and repeated surgery, and prolonged anti-inflammatory agents for gout. Read More

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November 2018
2 Reads

Antimicrobial resistance and molecular characterization of Neisseria gonorrhoeae isolates in Fukuoka, Japan, from 1996 to 2016.

J Glob Antimicrob Resist 2018 Nov 15. Epub 2018 Nov 15.

Department of Infection Control and Prevention, Faculty of Nursing, Toho University, Tokyo, Japan.

Objectives: We examined the antimicrobial resistance and molecular characteristics of Neisseria gonorrhoeae isolates obtained from 1996 -2005 (n=200) and 2008-2016 (n=200) in Fukuoka, Japan.

Methods: MICs were determined by agar dilution and sequence types (STs) were examined using N. gonorrhoeae multi-antigen sequence typing (NG-MAST). Read More

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November 2018
5 Reads

Associations between county-level voter turnout, county-level felony voter disenfranchisement, and sexually transmitted infections among women in the Southern United States.

Ann Epidemiol 2018 Oct 29. Epub 2018 Oct 29.

Institute for Global Health and Infectious Diseases, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA and Department of Health Sciences, Bouvé College of Health Sciences, Northeastern University, Boston, MA; Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC.

Purpose: Voting may play a critical role in the allocation of social and structural resources to communities, which in turn shapes neighborhood environments, and ultimately, an individual's sexually transmitted infection (STI) risk. We assessed relationships among county-level voter turnout and felony voter disenfranchisement, and STIs.

Methods: This cross-sectional multilevel analysis included 666 women in Alabama, Florida, Georgia, Mississippi, and North Carolina enrolled in the Women's Interagency HIV Study between 2013 and 2015. Read More

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October 2018
4 Reads

Sexuality, sexually transmitted infections and contraception among health sciences students in university of Lomé, Togo.

BMC Res Notes 2018 Nov 14;11(1):808. Epub 2018 Nov 14.

Department of Histology-Embryology, University of Lomé, Lomé, Togo.

Objectives: Evaluate the practice of sexuality, contraception and the risk of sexually transmitted infections among students in the Faculty of Health Sciences, University of Lomé, Togo.

Results: Three hundred and sixteen (316) students were interviewed, with a response rate of 43.3%. Read More

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November 2018
2 Reads

Disseminated gonococcal infections in patients receiving eculizumab: a case series.

Clin Infect Dis 2018 Nov 12. Epub 2018 Nov 12.

Division of Pharmacovigilance, Office of Surveillance and Epidemiology, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, MD, USA.

Background: Gonorrhea is the second most commonly reported notifiable condition in the United States (U.S.). Read More

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November 2018
7 Reads

The first year of the global Enhanced Gonococcal Antimicrobial Surveillance Programme (EGASP) in Bangkok, Thailand, 2015-2016.

PLoS One 2018 9;13(11):e0206419. Epub 2018 Nov 9.

Thailand Ministry of Public Health-U.S. Centers for Disease Control and Prevention Collaboration, Nonthaburi, Thailand.

Antimicrobial-resistant Neisseria gonorrhoeae (NG) infection is a global public health threat, and there is a critical need to monitor patterns of resistance and risk factors. In collaboration with the World Health Organization (WHO), the U.S. Read More

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November 2018
3 Reads

Risk of sexually transmitted infections following depressive disorder: A nationwide population-based cohort study.

Medicine (Baltimore) 2018 Oct;97(43):e12539

Department of Psychiatry, Chiayi Branch, Taichung Veterans General Hospital, Chiayi.

Depressive disorder is a severe mental disorder associated with functional and cognitive impairment. Numerous papers in the literature investigated associations between sexually transmitted infections (STIs) and psychiatric illnesses. However, the results of these studies are controversial. Read More

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October 2018
5 Reads

Unusual Neisseria species as a cause of infection in patients taking eculizumab.

J Infect 2018 Nov 6. Epub 2018 Nov 6.

Division of Pharmacovigilance, Office of Surveillance and Epidemiology, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, MD, USA.

Background: Non-meningococcal, non-gonococcal Neisseria spp. are typically commensal and rarely cause invasive disease. Eculizumab is a terminal complement inhibitor that increases susceptibility to meningococcal disease, but data on disease caused by typically-commensal Neisseria spp. Read More

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November 2018
7 Reads

Single-Dose Zoliflodacin (ETX0914) for Treatment of Urogenital Gonorrhea.

N Engl J Med 2018 11;379(19):1835-1845

From the Louisiana State University Health Sciences Center, New Orleans (S.N.T.); University of Alabama at Birmingham, Birmingham (J. Marrazzo, E.W.H.); University of Washington, Seattle (J. Marrazzo); Indiana University, Indianapolis (B.E.B.); University of North Carolina, Chapel Hill (A.C.S.), and FHI 360, Durham (S.M.J.) - both in North Carolina; Division of Microbiology and Infectious Diseases, National Institute of Allergy and Infectious Disease, Bethesda (J.L.), and Emmes, Rockville (M.R.W., H.K.) - both in Maryland; and Entasis Therapeutics, Waltham, MA (K.L., J. Mueller).

Background: Antibiotic-resistant Neisseria gonorrhoeae has prompted the development of new therapies. Zoliflodacin is a new antibiotic that inhibits DNA biosynthesis. In this multicenter, phase 2 trial, zoliflodacin was evaluated for the treatment of uncomplicated gonorrhea. Read More

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November 2018
23 Reads

Neisseria gonorrhoeae - Rising Infection Rates, Dwindling Treatment Options.

N Engl J Med 2018 Nov;379(19):1795-1797

From the Division of Disease Control, New York City Department of Health and Mental Hygiene, New York (S.B., D.C.D.); and the Division of STD Prevention, National Center for HIV, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta (S.B.).

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November 2018
6 Reads

Assessing the Impacts of Integrated Decision Support Software on Sexual Orientation Recording, Comprehensive Sexual Health Testing, and Detection of Infections Among Gay and Bisexual Men Attending General Practice: Observational Study.

JMIR Med Inform 2018 Nov 6;6(4):e10808. Epub 2018 Nov 6.

The Kirby Institute, University of New South Wales Sydney, Sydney, NSW, Australia.

Background: Gay and bisexual men are disproportionately affected by HIV and other sexually transmissible infections (STIs), yet opportunities for sexual health testing of this population are often missed or incomplete in general practice settings. Strategies are needed for improving the uptake and completeness of sexual health testing in this setting.

Objectives: The goal of the research was to evaluate the impact of an intervention centered around integrated decision support software and routine data feedback on the collection of sexual orientation data and sexual health testing among gay and bisexual men attending general practice. Read More

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November 2018
1 Read

Urogenital pathogens, associated with Trichomonas vaginalis, among pregnant women in Kilifi, Kenya: a nested case-control study.

BMC Infect Dis 2018 Nov 6;18(1):549. Epub 2018 Nov 6.

Laboratory Bacteriology Research, Faculty of Medicine and Health Sciences, Ghent University, De Pintelaan, 185, Ghent, Belgium.

Background: Screening of curable sexually transmitted infections is frequently oriented towards the diagnosis of chlamydia, gonorrhea, syphilis and trichomoniasis, whereas other pathogens, sometimes associated with similar urogenital syndromes, remain undiagnosed and/or untreated. Some of these pathogens are associated with adverse pregnancy outcomes.

Methods: In a nested case-control study, vaginal swabs from 79 pregnant women, i. Read More

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November 2018
10 Reads

Acceptability and efficacy of partner notification for curable sexually transmitted infections in sub-Saharan Africa: A systematic review.

Int J STD AIDS 2018 Nov 5:956462418803983. Epub 2018 Nov 5.

1 Department of Infectious Disease, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.

Comprehensive case management of sexually transmitted infections (STIs) includes partner notification. We reviewed the recent literature evaluating the acceptability and efficacy of partner notification strategies (i.e. Read More

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November 2018
2 Reads

The Association Between Multiple Abortions Within 1 Year and Previous Postabortal Desired Contraception at an Urban, Public Hospital.

J Womens Health (Larchmt) 2018 Nov 3. Epub 2018 Nov 3.

2 Division of Family Planning, John H. Stroger, Jr. Hospital of Cook County , Chicago, Illinois.

Objectives: To determine the proportion of women undergoing multiple abortions within 1 year at an urban, public hospital and the association with desired contraception after the index abortion.

Study Design: We conducted a retrospective analysis of all women undergoing abortion up to 13 weeks and 6 days gestation at Stroger Hospital from June 1, 2012 to May 31, 2014. We examined the proportion of women with additional abortions up to 1 year after the index abortion and contraception desired at the index abortion. Read More

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November 2018
5 Reads

Complete ciprofloxacin resistance in gonococcal isolates in an urban Ugandan clinic: findings from a cross-sectional study.

Int J STD AIDS 2018 Nov 4:956462418799017. Epub 2018 Nov 4.

3 Infectious Disease Institute, Makerere University College of Health Sciences, Kampala, Uganda.

Antimicrobial resistance (AMR) to gonorrhoea is a threat to global health security. There have been concerns expressed that countries with high rates of disease have poor surveillance. The objectives of the study were to determine the AMR patterns of Neisseria gonorrhoeae clinical isolates to antimicrobial agents in patients with HIV or high risk of HIV acquisition, to compare the concordance of disk diffusion and agar dilution as methods for determining AMR to N. Read More

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November 2018
1 Read

Haemophilus Species Isolated in Urethral Exudates as a Possible Causative Agent in Acute Urethritis: A Study of 38 Cases.

Actas Dermosifiliogr 2018 Oct 31. Epub 2018 Oct 31.

Servicio de Dermatología, Hospital General Universitario de Valencia, Valencia, España.

Introduction: The incidence of urethritis due to Haemophilus species is increasing. The main aim of this study was to describe the clinical and microbiological characteristics of patients with this form of urethritis. A secondary aim was to discuss the adequacy of treatments in patients with different types of antibiotic resistance. Read More

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October 2018
1 Read

Evaluating the Impact of Housing Status on Gonorrhea and Chlamydia Screening in an HIV Primary Care Setting.

Sex Transm Dis 2018 Oct 31. Epub 2018 Oct 31.

Division of HIV, Infectious Diseases and Global Medicine, Zuckerberg San Francisco General Hospital, University of California San Francisco.

Introduction: Gonorrhea and chlamydia (GC/CT) testing falls below recommended rates for people living with HIV (PLWH) in routine care. Despite evidence that homelessness and unstable housing (HUH) negatively impacts clinical outcomes for PLWH, little is known about GC/CT screening for HUH PLWH in routine care METHODS: Using an observational cohort of PWLH establishing care at a large publicly funded HIV clinic in San Francisco between February, 2013 - December, 2014 and with at least one primary care visit (PCV) before February 2016, we assessed GC/CT testing for HUH (staying outdoors, in shelters, in vehicles, or in places not made for habitation in the last year) compared to stably housed patients. We calculated 1) the odds of having GC/CT screening at a PCV using logistic regression with random effects to handle intra-subject correlations 2) the percent of time enrolled in clinical care in which patients had any GC/CT testing ("time-in-coverage") based on 180-day periods and using linear regression modeling. Read More

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October 2018
4 Reads

Inconsistent Collection and Reporting of Gender Minority Data in HIV and Sexually Transmitted Infection Surveillance Across the United States in 2015.

Am J Public Health 2018 Nov;108(S4):S274-S276

Andy Nguyen is with the Department of Medicine, Mount Auburn Hospital, Cambridge, MA, and Harvard Medical School, Boston, MA. Kenneth A. Katz is with the Department of Dermatology, Kaiser Permanente, San Francisco, CA. Kieron S. Leslie and Erin H. Amerson are with the Department of Dermatology, University of California, San Francisco.

Objectives: To describe collection and reporting of gender data, including for transgender individuals and other gender minorities, in HIV and sexually transmitted infection (STI) surveillance in the United States.

Methods: We performed a cross-sectional study of the top 50 US jurisdictions in 2015 for incident infections of HIV, gonorrhea, chlamydia, or primary and secondary syphilis. For each jurisdiction, we described gender-reporting options on HIV and STI data collection forms (also called confidential morbidity report forms) and data surveillance reports, which present aggregate data at either the county or the state level. Read More

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November 2018
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Single-dose Pharmacokinetics, Excretion, and Metabolism of Zoliflodacin, a Novel Spiropyrimidinetrione Antibiotic, in Healthy Volunteers.

Antimicrob Agents Chemother 2018 Oct 29. Epub 2018 Oct 29.

ECD Serono, One Technology Place, Rockland, MA 02370.

Zoliflodacin is a novel spiropyrimidinetrione with activity against bacterial Type II topoisomerases that inhibits DNA biosynthesis and results in accumulation of double strand cleavages in bacteria. We report results from two Phase 1 studies that investigated the safety, tolerability, and pharmacokinetics (PK) of zoliflodacin, and the absorption, distribution, metabolism, and excretion (ADME) after single doses in healthy volunteers. In the single ascending dose study, zoliflodacin was rapidly absorbed with a T between 1. Read More

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October 2018
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Longitudinal association of gonorrhea and bacterial vaginosis with repeat chlamydia diagnoses among U.S. Army women: a retrospective cohort analysis.

Mil Med Res 2018 10 30;5(1):37. Epub 2018 Oct 30.

Armed Forces Health Surveillance Branch, Public Health Division, Defense Health Agency, Silver Spring, MD, USA.

Background: Historically, sexually transmitted infections have affected the health of the U.S. military. Read More

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October 2018
6 Reads