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J Ethnopharmacol 2021 Jul 7;279:114400. Epub 2021 Jul 7.

Department of Integrative Biotechnology, Biomedical Institute for Convergence at SKKU (BICS), Sungkyunkwan University, Suwon, 16419, Republic of Korea. Electronic address:

Ethnopharmacological Relevance: Saururus chinensis (Lour.) Baill (Saururaceae), also known as Asian lizard's tail, is a plant commonly found in East Asia. Its leaves have been used in traditional medicine to treat many diseases such as edema, pneumonia, hypertension, leproma, jaundice, gonorrhea, and rheumatoid arthritis. Read More

J Gen Intern Med 2021 May 19. Epub 2021 May 19.

Department of Medicine, Oregon Health and Science University, Portland, OR, USA.

A previously healthy 36-year-old woman was admitted to the hospital with vaginal discharge, bilateral ankle pain, and a lower extremity skin rash, all of which developed after unprotected vaginal intercourse with a new male partner. On examination, there was a petechial and purpuric rash involving the lower extremities and bilateral tenosynovitis of the ankle dorsiflexor tendons. Urine NAAT was positive for Neisseria gonorrhea, confirming disseminated gonococcal infection (DGI). Read More

J Investig Med High Impact Case Rep 2021 Jan-Dec;9:23247096211012194

University of Florida College of Medicine, Jacksonville, FL, USA.

, a gram-negative coccus, is a major cause of morbidity among sexually active individuals. Hematogenous spread of from the initial site of infection is thought to occur in only 0.5% to 3% of infected patients. Read More

Int J Surg Case Rep 2021 Mar 24;80:105701. Epub 2021 Feb 24.

Community Memorial Health System, Ventura, CA, USA.

Introduction: Septic arthritis is an orthopedic emergency that requires rapid diagnosis and treatment due to the rapid destruction to cartilage. The responsible organism and etiology differs depending on patient age, especially in children. Gonococcal Arthritis in toddlers is a rare occurrence with few documented cases in the literature. Read More

BMJ Case Rep 2021 Feb 1;14(2). Epub 2021 Feb 1.

Infectious Diseases, The George Washington University School of Medicine and Health Sciences, Washington, DC, USA.

We report a case of septic polyarthritis caused by in a woman with neuromyelitis optica who was receiving rituximab. Her case exemplifies some of the unique characteristics of invasive infections that can lead to delayed diagnosis as well as treatment challenges including recurrence following antibiotic discontinuation. Read More

Intern Med J 2020 Dec 21. Epub 2020 Dec 21.

Dept. Rheumatology, Sir Charles Gairdner Hospital, Perth, Australia.

Objective: To investigate the frequency, risk factors and long-term outcome of gonococcal arthritis in Western Australia (WA).

Methods: A population-based data linkage study of patients with a hospital-based diagnosis of gonococcal arthritis (GA) in WA between 1990-2014. Demographics, standardised incidence rates (IR) per million and comorbidity accrued before (lookback 186 months ,IQR 86-267) and after the index hospital contact for GA (follow-up 100 months, IQR 60-209). Read More

J Osteopath Med 2021 02;121(2):243

Department of Internal Medicine , The University of Louisville , Louisville , KY , USA.

IDCases 2020 29;22:e00967. Epub 2020 Sep 29.

Staten Island University Hospital, Northwell Health, 475 Seaview Ave, Staten Island, NY, 10305, United States.

Disseminated gonococcal infection (DGI) commonly presents with arthritis, flexor compartment tenosynovitis, and dermatitis. Osteomyelitis and extensor compartment tenosynovitis caused by DGI is rarely reported in medical literature. We describe one such case of extensor tenosynovitis and osteomyelitis of the wrist joint which symptomatically improved after arthrotomy and intravenous antibiotics. Read More

Access Microbiol 2019 20;1(7):e000052. Epub 2019 Aug 20.

Division of Infection, Inflammation and Immunology, University of Glasgow Medical School, Glasgow, UK.

is the most common non-gonococcal aetiology of septic arthritis. The efficacy of iclaprim against LS-1, a clinical strain identified from a patient with septic arthritis, was studied in MF1 mice to evaluate the activity of iclaprim, which is in clinical development, in preventing joint infections. Iclaprim (2. Read More

J Pediatric Infect Dis Soc 2021 Apr;10(3):367-369

Department of Pediatrics, University of California-San Diego, San Diego, California, USA.

Disseminated gonococcal infection (DGI) often manifests as gonococcal arthritis and may carry significant morbidity. However, diagnosis remains elusive due to limited sensitivity of available diagnostic tests. We used metagenomic next-generation sequencing to detect Neisseria gonorrhoeae from culture-negative joint aspirates of 2 patients with clinically diagnosed DGI. Read More

J Community Hosp Intern Med Perspect 2020 May 21;10(2):174-178. Epub 2020 May 21.

Methodist Dallas Medical Center, Dallas, TX, USA.

A 48-year-old male presented to the emergency room for 2 weeks of joint pain and swelling of his four extremities. His symptoms started suddenly and were quite debilitating. His hands, fingers, knees, and ankles were so swollen and painful that he was unable to get out of bed and had to use crutches to ambulate. Read More

RMD Open 2020 08;6(2)

Department of Nephrology and Rheumatology, Kyorin University School of Medicine, Shinkawa, Mitaka-shi, Tokyo, Japan.

Reactive arthritis (ReA) is typically preceded by sexually transmitted disease or gastrointestinal infection. An association has also been reported with bacterial and viral respiratory infections. Herein, we report the first case of ReA after the he severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Read More

IDCases 2020 18;21:e00875. Epub 2020 Jun 18.

Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, 500 Hofstra Blvd, Hempstead, New York, 11549, United States.

We report a case of a female teenager with gonococcal septic arthritis of the right shoulder that also caused osteomyelitis of the humeral head. Infection with is a frequently diagnosed sexually transmitted infection in the sexually active teenage population and disseminated gonococcal infection (DGI) is the most common systemic manifestation of acute gonorrhea. DGI commonly involves acute arthritis, tenosynovitis and dermatitis with less common complications of endocarditis, hepatitis and meningitis. Read More

Sex Transm Dis 2020 09;47(9):e36-e38

Department of Radiology, Division of Musculoskeletal Imaging.

Neisseria gonorrhoeae osteomyelitis is a rare complication of disseminated gonococcal infection. As the rates of N. gonorrhoeae continue to increase in the United States, clinicians may encounter patients with disseminated gonococcal infection complicated by gonococcal osteomyelitis. Read More

Infez Med 2020 Jun;28(2):253-257

Division of Infectious Diseases, Department of Medicine, University of Miami, Miller School of Medicine, Miami, Florida, USA.

Neisseria gonorrhoeae is an uncommon present-day cause of septic arthritis. It is generally seen in the younger patient population and is often difficult to isolate in the lab. Blood cultures performed as routine work are usually negative, and when positive tend to be seen in the classic form of disseminated gonococcal infection. Read More

Curr Urol 2020 Mar 20;14(1):1-13. Epub 2020 Mar 20.

East and North Hertfordshire NHS Trust, Department of Urology, Lister Hospital, Stevenage.

Background: It is estimated that between 50 and 89% of non-gonococcal urethritis is not caused by . Associations between non-chlamydial non-gonococcal urethritis (NCNGU) with balanoposthitis, epididymo-orchitis and reactive arthritis have been suggested, but evidence to support these often-theoretical relationships is sparse and further investigation is called for. Concerns over increasing antimicrobial resistance has rendered the need for clarity over this question ever more pressing in recent years. Read More

IDCases 2020 23;20:e00763. Epub 2020 Apr 23.

Department of Infectious Disease, Jersey Shore University Medical Center, Hackensack Meridian Health, Neptune, NJ 07753, United States.

Disseminated gonococcal infection (DGI) is seen in about 0.5-3% of patients with . Patients with DGI present with mucosal involvement, septic arthritis and sometimes bacteremia. Read More

J Community Hosp Intern Med Perspect 2020 10;10(1):55-59. Epub 2020 Feb 10.

Department of Internal Medicine, OSF Saint Francis Medical Center, Peoria, IL, USA.

Disseminated Neisseria gonorrhea (N. Gonorrhoeae) infection can present with polyarticular involvement. Acute vertebral discitis/osteomyelitis due to this organism infection has been rarely reported. Read More

BMJ Case Rep 2020 Feb 3;13(2). Epub 2020 Feb 3.

Internal Medicine, Northwestern Memorial Hospital, Chicago, Illinois, USA.

is the causative organism in 0.6%-1.2% of septic arthritis cases in North America and Europe, and classically presents as migratory polyarthralgias and tenosynovitis, with later development of septic oligoarthritis. Read More

Saudi Pharm J 2019 Dec 11;27(8):1210-1215. Epub 2019 Oct 11.

Department of Pharmaceutical Chemistry, College of Pharmacy, Prince Sattam Bin Abdulaziz University, P.O. Box No. 173, Al-Kharj 11942, Saudi Arabia.

Traditional Pertinence: Sweet (Linn.), belongs to the family convolvulaceae, a traditional Indian medicinal herb, has been used to treat acute/chronic ulcers, gonorrhea, rheumatoid arthritis and several nervous disorders having a long history.

Aim Of The Study: A broad spectrum approach of this work was to find out the antioxidant activity of seeds, and antioxidant assay were performed. Read More

IDCases 2020 5;19:e00662. Epub 2019 Nov 5.

Icahn School of Medicine at Mount Sinai, Mount Sinai Beth Israel, United States.

We present a case of a generally healthy, immunocompetent, 57 year old male on HIV pre-exposure prophylaxis (PrEP) who developed the sudden onset of right wrist pain and swelling with associated left second finger tenosynovitis, due to a disseminated gonococcal infection (DGI) with purulent arthritis. This case's aim is to demonstrate a well-documented but infrequently seen manifestation of infection and to highlight the need for awareness of extragenital manifestations of gonococcal infection in the era of HIV PrEP. DGI accounts for less than 3 % of infections, with purulent arthritis being one presentation. Read More

Adv Rheumatol 2019 11 15;59(1):50. Epub 2019 Nov 15.

Pediatric Rheumatology Unit, Children's Institute, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Av. Dr. Eneas Carvalho Aguiar, 647 - Cerqueira César, São Paulo, SP, 05403-000, Brazil.

Background: To evaluate human papillomavirus (HPV), Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (NG) infections in juvenile idiopathic arthritis (JIA) patients.

Methods: After exclusion, 33 female adolescent and young JIA patients (ILAR criteria) and 28 healthy controls were selected for this study. Demographic data, gynecological, sexual function, cervical cytology and histological abnormalities were evaluated. Read More

Med Sante Trop 2019 Aug;29(3):251-252

Service des maladies infectieuses, CHU Donka, Université Gamal Abdel Nasser de Conakry, Guinée.

We report the case of a 32-year-old man with septic arthritis and Neisseria gonorrhoeae tenosynovitis, diagnosed after joint fluid culture treated with ceftriaxone. It is one of the most frequent causes of purulent septic arthritis in young people in undeveloped countries. Early diagnosis is important to avoid complications. Read More

Cureus 2019 Jul 24;11(7):e5222. Epub 2019 Jul 24.

Family Medicine, Prohealth Medical Group, Waukesha, USA.

Reactive arthritis is defined as a sterile inflammation involving the synovial membrane, tendons and/or fascia, elicited by an infection, usually originating from gastrointestinal or genitourinary tracts. Reactive arthritis can also be triggered by a sexually transmitted disease, referred to as sexually acquired reactive arthritis. The most common identifiable cause of non-gonococcal urethritis is . Read More

BMC Rheumatol 2019 16;3:38. Epub 2019 Sep 16.

Rheumatic Disease Unit, Department of Internal Medicine, Phramongkutklao Hospital and College of Medicine, 315 Ratchawithi road, Bangkok, Ratchathewi District 10400 Thailand.

Background: Group B Streptococcus (GBS) emerged as the frequent pathogen for septic arthritis. There was no study comparing risks, clinical presentations and outcomes between GBS septic arthritis and other bacterial septic arthritis.The aim of this study is to evaluate the differences in risks, clinical presentations, and outcomes of GBS septic arthritis and other bacterial septic arthritis, and identify independent risks and clinical presentations suggesting GBS septic arthritis. Read More

Am J Trop Med Hyg 2019 10;101(4):753-760

Northern Territory Centre for Disease Control, Darwin, Australia.

The "Top End" of Australia is presently experiencing a gonorrhea epidemic. Gonococcal infection is usually limited to mucosal tissues but can lead to disseminated gonococcal infection (DGI), joint destruction, and severe sepsis. This study aimed to explore the epidemiology, presentation, management, and health-care impact of DGI in the Top End of the Northern Territory. Read More

Clin Med (Lond) 2019 07;19(4):340-341

Chang Gung Memorial Hospital and Chang Gung University, Taoyuan, Taiwan

Clin Rheumatol 2019 Aug 27;38(8):2083-2088. Epub 2019 Mar 27.

Department of Medicine, Schulich School of Medicine & Dentistry, Western University, London, Canada.

Objective: To characterize rheumatologists' perspectives on evolving trends of reactive arthritis (ReA).

Methods: After ethics approval, 548 members of the Canadian Rheumatology Association were surveyed with 37 questions covering their demographic information, subspecialty, level of experience, practice setting and opinions on prevalence, treatment, and causes of ReA. Results were analyzed with descriptive statistics. Read More

Mil Med 2019 07;184(7-8):e368-e370

Department of Chemistry and Life Science, Bartlett Hall, 753 Cullum Road, West Point, NY.

Lyme disease is a continuing threat to military personnel operating in arboriferous and mountainous environments. Here we present the case of a 24-year-old Second Lieutenant, a recent graduate from the United States Military Academy, with a history of Lyme disease who developed recurrent knee effusions following surgery to correct a hip impingement. Although gonococcal arthritis was initially suspected from preliminary laboratory results, a comprehensive evaluation contradicted this diagnosis. Read More

J Arthroplasty 2019 02 25;34(2):359-364. Epub 2018 Oct 25.

Department of Molecular Pathology, National Research Institute of Tuberculosis and Lung Diseases, Shahid Behshti University of Medical Sciences, Tehran, Iran; Department of Molecular Biology, Dr. Khosroshahi's Pathobiology Laboratory, Tehran, Iran.

Background: PCR-RFLP (polymerase chain reaction-restriction fragment length polymorphism) techniques have been used for the diagnosis of bacteria in some infections. In this study, we aimed to evaluate the diagnostic accuracy of PCR for the diagnosis of prosthetic joint infections (PJI) and to identify isolated microorganisms, using the RFLP method.

Methods: During January 2015 to January 2018, patients who were suspected of having PJI after arthroplasty surgery or were candidates for revision surgery due to loosening of implant entered the study. Read More