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Microbes Infect 2022 Aug 5:105037. Epub 2022 Aug 5.

Laboratório de Investigação Médica, Bacteriologia e Resistência Antimicrobiana, Instituto de Medicina Tropical da FMUSP (LIM 49), Av. Dr. Enéas Carvalho de Aguiar, 470, São Paulo, CEP: 05403-000; Brazil. Electronic address:

In this study, we describe a case report of gonococcal arthritis in a Systemic Lupus Erythematosus patient. Although several mechanisms favor disseminated gonococcal infection (DGI) in patients immunosuppressed by SLE, this association is rarely reported in literature. We performed whole genome sequencing (WGS) of the etiologic agent involved and molecular analysis using a global collection of N. Read More

Clin Rheumatol 2022 May 20. Epub 2022 May 20.

Internal Medicine Department, CHU Nord, La Réunion, France.

Objectives: Extra-genital manifestations of gonococcal infection are rare (0.5-3%). Among them, gonococcal arthritis (GA) is the most frequent, accounting for 30-90% of disseminated infections. Read More

CMAJ 2022 04;194(14):E534-E536

Section d'infectiologie (Boodman, MacKenzie, Wuerz), Département de médecine interne et Département de microbiologie médicale et d'infectiologie (Boodman, Alexander), Faculté de médecine Max Rady, Université du Manitoba; Programme VIH du Manitoba (MacKenzie); Section de médecine interne (Navarro), Département de médecine interne, Faculté de médecine Max Rady, Université du Manitoba; Laboratoire provincial Cadham (Alexander); Département de sciences de la santé communautaire (Wuerz), Faculté de médecine Max Rady, Université du Manitoba, Winnipeg, Man.

IDCases 2022 15;28:e01474. Epub 2022 Mar 15.

Division of Infectious Diseases, University of Connecticut School of Medicine, Farmington, CT, United States.

Gonorrhea caused by is a very common sexually transmitted infection in the United States and World-wide (Kirkcaldy et al., 2019) [1]. The population with highest prevalence is young sexually active adults aged 15-24 years. Read More

J Clin Microbiol 2022 04 23;60(4):e0253021. Epub 2022 Mar 23.

Cadham Provincial Laboratory, Winnipeg, Manitoba, Canada.

Gonorrhea is a sexually transmitted bacterial infection caused by Neisseria gonorrhoeae. Nucleic acid amplification testing is the preferred method for routine diagnosis of gonorrhea from urogenital specimens, but culture is commonly used for diagnosis of disseminated infections, including gonococcal arthritis. The Hologic Aptima Combo 2 (AC2), a transcription-mediated amplification assay, is FDA and Health Canada licensed for detection of N. Read More

Sex Transm Dis 2022 Mar 10. Epub 2022 Mar 10.

Division of Infectious Diseases, Department of Internal Medicine; University of California, San Francisco, Fresno, California, USA.

Abstract: Infection caused by Neisseria gonorrhoeae is a global health concern. Occasionally, gonococcal infections may disseminate and cause clinical syndromes, such as arthritis, tenosynovitis, and skin lesions. Here, we report a very rare presentation of a liver abscess due to Neisseria gonorrhoeae in a 29-year-old woman with sickle cell disease without prior genitourinary complaints. Read More

Am J Ophthalmol Case Rep 2022 Mar 10;25:101415. Epub 2022 Feb 10.

Department of Ophthalmology, Bernice and Harvey Jones Eye Institute, University of Arkansas for Medical Sciences, Little Rock, AR, USA.

Purpose: To report a rare case of endogenous endophthalmitis caused by Staphylococcus capitis.

Observation: A 34-year-old male patient with a history of gonococcal urethritis and arthritis presented with right endogenous endophthalmitis. Vitreous biopsy culture confirmed Staphylococcus capitis involvement. Read More

CMAJ 2021 12;193(50):E1918-E1920

Section of Infectious Diseases (Boodman, MacKenzie, Wuerz), Department of Internal Medicine, and Department of Medical Microbiology and Infectious Diseases (Boodman, Alexander), Max Rady College of Medicine, University of Manitoba; Manitoba HIV Program (MacKenzie); Section of Internal Medicine (Navarro), Department of Internal Medicine, Max Rady College of Medicine, University of Manitoba; Cadham Provincial Laboratory (Alexander); Department of Community Health Sciences (Wuerz), Max Rady College of Medicine, University of Manitoba, Winnipeg, Man.

Cureus 2021 Sep 14;13(9):e17955. Epub 2021 Sep 14.

Internal Medicine, Rochester Regional Health, Rochester, USA.

Disseminated gonococcal infection occurs in 0.5%-3% of gonorrhea cases, usually in the form of either a triad of arthralgia, tenosynovitis, and skin lesions or purulent arthritis. Other rare complications include gonococcal infective endocarditis that occurs in 1%-2% of cases with 99 cases reported in the literature since 1938. Read More

Int J Rheum Dis 2021 Nov 5;24(11):1386-1393. Epub 2021 Oct 5.

Department Rheumatology, Sir Charles Gairdner Hospital, Perth, Western Australia, Australia.

Objective: To describe the incidence and long-term outcome of non-gonococcal septic arthritis (SA) in Western Australia (WA).

Methods: Newman criteria were applied to define culture-positive SA and suspected SA cases in the state-wide West Australian Rheumatic Diseases Epidemiological Registry with longitudinally linked health data for patients >16 years with a first diagnostic code of pyogenic arthritis (711.xx [ICD-9-CM] and M00. Read More

Dermatol Online J 2021 Jul 15;27(7). Epub 2021 Jul 15.

Department of Oral Pathology and Medicine, Faculty of Dentistry, University of Chile, Santiago.

Reactive arthritis is an extremely rare spondyloarthritis that affects the peripheral joints and spine, resulting in common symptoms such as arthritis, urethritis, conjunctivitis, and mucocutaneous lesions. On rare occasions, oral lesions such as circinate erosions on the hard and soft palate, gums, tongue, and cheeks may occur. Reactive arthritis may develop during or after genitourinary or gastrointestinal bacterial infections such as Shigella, Salmonella, Yersinia, and Chlamydia. Read More

J Ethnopharmacol 2021 Oct 7;279:114400. Epub 2021 Jul 7.

Department of Integrative Biotechnology, Biomedical Institute for Convergence at SKKU (BICS), Sungkyunkwan University, Suwon, 16419, Republic of Korea. Electronic address:

Ethnopharmacological Relevance: Saururus chinensis (Lour.) Baill (Saururaceae), also known as Asian lizard's tail, is a plant commonly found in East Asia. Its leaves have been used in traditional medicine to treat many diseases such as edema, pneumonia, hypertension, leproma, jaundice, gonorrhea, and rheumatoid arthritis. Read More

J Gen Intern Med 2021 09 19;36(9):2836-2838. Epub 2021 May 19.

Department of Medicine, Oregon Health and Science University, Portland, OR, USA.

A previously healthy 36-year-old woman was admitted to the hospital with vaginal discharge, bilateral ankle pain, and a lower extremity skin rash, all of which developed after unprotected vaginal intercourse with a new male partner. On examination, there was a petechial and purpuric rash involving the lower extremities and bilateral tenosynovitis of the ankle dorsiflexor tendons. Urine NAAT was positive for Neisseria gonorrhea, confirming disseminated gonococcal infection (DGI). Read More

J Investig Med High Impact Case Rep 2021 Jan-Dec;9:23247096211012194

University of Florida College of Medicine, Jacksonville, FL, USA.

, a gram-negative coccus, is a major cause of morbidity among sexually active individuals. Hematogenous spread of from the initial site of infection is thought to occur in only 0.5% to 3% of infected patients. Read More

Am J Med 2021 09 1;134(9):1107-1109. Epub 2021 Apr 1.

Division of Rheumatology, Mayo Clinic, Rochester, Minn. Electronic address:

Rev Esp Quimioter 2021 Jun 16;34(3):256-258. Epub 2021 Mar 16.

Inés Olaya García Rodríguez, Servicio de Microbiología y Control de la Infección. Hospital Universitario de Canarias. Crtra Ofra s/n. 38320. La Cuesta. La Laguna. Spain.

Int J Surg Case Rep 2021 Mar 24;80:105701. Epub 2021 Feb 24.

Community Memorial Health System, Ventura, CA, USA.

Introduction: Septic arthritis is an orthopedic emergency that requires rapid diagnosis and treatment due to the rapid destruction to cartilage. The responsible organism and etiology differs depending on patient age, especially in children. Gonococcal Arthritis in toddlers is a rare occurrence with few documented cases in the literature. Read More

BMJ Case Rep 2021 Feb 1;14(2). Epub 2021 Feb 1.

Infectious Diseases, The George Washington University School of Medicine and Health Sciences, Washington, DC, USA.

We report a case of septic polyarthritis caused by in a woman with neuromyelitis optica who was receiving rituximab. Her case exemplifies some of the unique characteristics of invasive infections that can lead to delayed diagnosis as well as treatment challenges including recurrence following antibiotic discontinuation. Read More

Intern Med J 2022 Jun 31;52(6):1029-1034. Epub 2022 May 31.

Department of Rheumatology, Sir Charles Gairdner Hospital, Perth, Western Australia, Australia.

Background: A high prevalence of gonococcal infections has been reported from remote parts of Western Australia, but the occurrence of disseminated infection leading to arthritis has not been studied.

Aims: To investigate the frequency, risk factors and long-term outcome of gonococcal arthritis (GA) in Western Australia (WA).

Methods: A population-based data linkage study of patients with a hospital-based diagnosis of GA in WA between 1990 and 2014. Read More

J Osteopath Med 2021 02;121(2):243

Department of Internal Medicine , The University of Louisville , Louisville , KY , USA.

IDCases 2020 29;22:e00967. Epub 2020 Sep 29.

Staten Island University Hospital, Northwell Health, 475 Seaview Ave, Staten Island, NY, 10305, United States.

Disseminated gonococcal infection (DGI) commonly presents with arthritis, flexor compartment tenosynovitis, and dermatitis. Osteomyelitis and extensor compartment tenosynovitis caused by DGI is rarely reported in medical literature. We describe one such case of extensor tenosynovitis and osteomyelitis of the wrist joint which symptomatically improved after arthrotomy and intravenous antibiotics. Read More

Access Microbiol 2019 20;1(7):e000052. Epub 2019 Aug 20.

Division of Infection, Inflammation and Immunology, University of Glasgow Medical School, Glasgow, UK.

is the most common non-gonococcal aetiology of septic arthritis. The efficacy of iclaprim against LS-1, a clinical strain identified from a patient with septic arthritis, was studied in MF1 mice to evaluate the activity of iclaprim, which is in clinical development, in preventing joint infections. Iclaprim (2. Read More

J Pediatric Infect Dis Soc 2021 Apr;10(3):367-369

Department of Pediatrics, University of California-San Diego, San Diego, California, USA.

Disseminated gonococcal infection (DGI) often manifests as gonococcal arthritis and may carry significant morbidity. However, diagnosis remains elusive due to limited sensitivity of available diagnostic tests. We used metagenomic next-generation sequencing to detect Neisseria gonorrhoeae from culture-negative joint aspirates of 2 patients with clinically diagnosed DGI. Read More

J Community Hosp Intern Med Perspect 2020 May 21;10(2):174-178. Epub 2020 May 21.

Methodist Dallas Medical Center, Dallas, TX, USA.

A 48-year-old male presented to the emergency room for 2 weeks of joint pain and swelling of his four extremities. His symptoms started suddenly and were quite debilitating. His hands, fingers, knees, and ankles were so swollen and painful that he was unable to get out of bed and had to use crutches to ambulate. Read More

RMD Open 2020 08;6(2)

Department of Nephrology and Rheumatology, Kyorin University School of Medicine, Shinkawa, Mitaka-shi, Tokyo, Japan.

Reactive arthritis (ReA) is typically preceded by sexually transmitted disease or gastrointestinal infection. An association has also been reported with bacterial and viral respiratory infections. Herein, we report the first case of ReA after the he severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Read More

IDCases 2020 18;21:e00875. Epub 2020 Jun 18.

Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, 500 Hofstra Blvd, Hempstead, New York, 11549, United States.

We report a case of a female teenager with gonococcal septic arthritis of the right shoulder that also caused osteomyelitis of the humeral head. Infection with is a frequently diagnosed sexually transmitted infection in the sexually active teenage population and disseminated gonococcal infection (DGI) is the most common systemic manifestation of acute gonorrhea. DGI commonly involves acute arthritis, tenosynovitis and dermatitis with less common complications of endocarditis, hepatitis and meningitis. Read More

Sex Transm Dis 2020 09;47(9):e36-e38

Department of Radiology, Division of Musculoskeletal Imaging.

Neisseria gonorrhoeae osteomyelitis is a rare complication of disseminated gonococcal infection. As the rates of N. gonorrhoeae continue to increase in the United States, clinicians may encounter patients with disseminated gonococcal infection complicated by gonococcal osteomyelitis. Read More

Infez Med 2020 Jun;28(2):253-257

Division of Infectious Diseases, Department of Medicine, University of Miami, Miller School of Medicine, Miami, Florida, USA.

Neisseria gonorrhoeae is an uncommon present-day cause of septic arthritis. It is generally seen in the younger patient population and is often difficult to isolate in the lab. Blood cultures performed as routine work are usually negative, and when positive tend to be seen in the classic form of disseminated gonococcal infection. Read More

Curr Urol 2020 Mar 20;14(1):1-13. Epub 2020 Mar 20.

East and North Hertfordshire NHS Trust, Department of Urology, Lister Hospital, Stevenage.

Background: It is estimated that between 50 and 89% of non-gonococcal urethritis is not caused by . Associations between non-chlamydial non-gonococcal urethritis (NCNGU) with balanoposthitis, epididymo-orchitis and reactive arthritis have been suggested, but evidence to support these often-theoretical relationships is sparse and further investigation is called for. Concerns over increasing antimicrobial resistance has rendered the need for clarity over this question ever more pressing in recent years. Read More

IDCases 2020 23;20:e00763. Epub 2020 Apr 23.

Department of Infectious Disease, Jersey Shore University Medical Center, Hackensack Meridian Health, Neptune, NJ 07753, United States.

Disseminated gonococcal infection (DGI) is seen in about 0.5-3% of patients with . Patients with DGI present with mucosal involvement, septic arthritis and sometimes bacteremia. Read More