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Wellcome Open Res 2018 25;3:65. Epub 2018 Sep 25.

Medical Research Council Integrative Epidemiology Unit, Avon Longitudinal Study of Parents and Children, Population Health Science, Bristol Medical School, University of Bristol, Bristol, BS8 2BN, UK.

The (fucosyltransferase-2) gene determines blood group secretor status. Being homozygous for the inactive "non-secretor" rs601338(A) allele confers resistance to certain infections (e.g. Read More

J Emerg Med 2018 06 21;54(6):844-848. Epub 2018 Apr 21.

Department of Emergency Medicine, Northwell Health Long Island Jewish Medical Center, New Hyde Park, New York.

Background: Gonorrhea is the second most common sexually transmitted infection. Disseminated gonococcal infection (DGI) consists of gonococcal infection plus one or more of the triad of arthritis, tenosynovitis, and dermatitis. Diagnosis in the emergency department (ED) must be suspected clinically, as confirmatory tests are often not available. Read More

J Clin Microbiol 2018 04 26;56(4). Epub 2018 Mar 26.

Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA

J Clin Microbiol 2018 04 26;56(4). Epub 2018 Mar 26.

Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA

Am J Case Rep 2017 Dec 29;18:1396-1400. Epub 2017 Dec 29.

Department of Internal Medicine, Hospital de Clínicas "Jose de San Martin", University of Buenos Aires, Buenos Aires, Argentina.

BACKGROUND Fitz-Hugh-Curtis (FHC) syndrome is a perihepatitis linked to inflammatory pelvic disease. It can be caused by Neisseria gonorrhoeae or Chlamydia trachomatis infections. FHC syndrome usually presents with pain in the right hypochondrium and fever, associated with symptoms and signs of pelvic infection in women. Read More

Reumatol Clin 2017 Nov 1. Epub 2017 Nov 1.

Servicio de Microbiología, Hospital Universitario La Paz, Madrid, España.

Disseminated gonococcal infection is a rare presentation of the sexually transmitted pathogen, Neisseria gonorrhoeae. Here, we report the case of a 64-year-old woman with disseminated gonococcal infection, which started with symptoms of oligoarthritis and malaise. Neisseria gonorrhoeae was identified in the carpal synovial fluid. Read More

J Ethnopharmacol 2018 Jan 27;211:295-310. Epub 2017 Sep 27.

Natural Product Chemistry Division, CSIR-Indian Institute of Integrative Medicine, Jammu 180001, India.

Ethnopharmacological Relevance: Tinospora cordifolia is a miraculous ayurvedic herb used in the treatment of innumerable diseases such as diabetes, gonorrhea, secondary syphilis, anaemia, rheumatoid arthritis, dermatological diseases, cancer, gout, jaundice, asthma, leprosy, in the treatment of bone fractures, liver & intestinal disorders, purifies the blood, gives new life to the whole body; (rejuvenating herb) and many more. Recent studies have revealed the anticancer potential of this plant but not much work has been done on the anticancer chemical constituents actually responsible for its amazing anticancer effects. This prompted us to investigate this plant further for new potent anticancer molecules. Read More

N Engl J Med 2017 09;377(12):1189-1195

From the Departments of Medicine (L.P., S.B.N., S.E.T.) and Pathology (S.E.T.), Massachusetts General Hospital, and the Departments of Medicine (L.P., S.B.N., S.E.T.) and Pathology (S.E.T.), Harvard Medical School - both in Boston.

J Bone Jt Infect 2017 18;2(3):160-162. Epub 2017 Aug 18.

Department of Infectious Diseases, Princess Alexandra Hospital, Queensland Health, Woolloongabba, Queensland, Australia.

is a common sexually transmitted infection worldwide. Disseminated gonococcal infection is an infrequent presentation and rarely can be associated with septic arthritis. Incidence of this infection is rising, both internationally and in older age groups. Read More

Rev Med Interne 2018 Jan 24;39(1):54-56. Epub 2017 Aug 24.

Service des maladies infectieuses et tropicales, centre hospitalier universitaire de Bordeaux, place Amélie-Raba-Léon, 33076 Bordeaux cedex, France.

Introduction: The incidence of Neisseria gonorrhoeae septic arthritis remains low in the general population. Its clinical and microbiological diagnostic remains difficult.

Case Report: We report a 44-year-old man who presented with a monoarthritis of the right ankle. Read More

Eur J Intern Med 2017 Dec 6;46:e3-e4. Epub 2017 May 6.

Department of Pathology, Tenon Hospital (AP-HP), Paris, France. Electronic address:

Dermatol Online J 2017 Jan 15;23(1). Epub 2017 Jan 15.

Medical School, Louisiana State University Health Sciences Center, New Orleans.

Background: Sexually transmitted infections, includingurogenital gonorrheal infection, are a growing healthconcern in the United States. Nearly 50% of cervicalinfections are asymptomatic. If left undiagnosedand untreated, there is a risk of disseminatedinfection. Read More

J Ethnopharmacol 2017 Feb 18;198:302-312. Epub 2017 Jan 18.

Department of Pharmacognosy and Pharmaceutical Chemistry, College of Pharmacy, Taibah University, Al Madinah Al Munawwarah 30078, Saudi Arabia. Electronic address:

Ethnopharmacological Relevance: Cancer has proceeded to surpass one of the most chronic illnesses to be the major cause of mortality in both the developing and developed world. Garcinia mangostana L. (mangosteen, family Guttiferae) known as the queen of fruits, is one of the most popular tropical fruits. Read More

Tidsskr Nor Laegeforen 2016 Dec 20;136(23-24):1999-2001. Epub 2016 Dec 20.

Medisinsk avdeling Haukeland universitetssykehus.

Kansenshogaku Zasshi 2016 Nov;90(6):809-13

We report a case of iatrogenic vesical tuberculosis diagnosed 4 years after intravesical immunotherapy using Bacillus Calmette- Guérin (BCG) for the treatment of bladder carcinoma. A 72-year-old man underwent a transurethral resection (TUR) of multiple noninvasive urothelial carcinomas and intravesical BCG infusion (40 mg/week) for 7 weeks to prevent the recurrence of bladder carcinoma. BCG infusion therapy was terminated because of the appearance of Reiter's syndrome, including arthritis of the left toe joint, conjunctivitis and non-gonococcal urethritis as complications. Read More

J Community Hosp Intern Med Perspect 2016 6;6(3):31841. Epub 2016 Jul 6.

Department of Medicine, Reading Hospital and Medical Centre, West Reading, PA, USA.

Gonococcus typically affects the mucosal surfaces but in rare cases can spread to bloodstream causing disseminated gonococcal infection (DGI). The usual presentation of DGI is rash, polyarthralgia, and tenosynovitis. We present the case of a 23-year-old female who presented to our hospital with pustular rash and tenosynovitis of hand and was sent home on Augmentin. Read More

Curr Pharm Des 2016 ;22(27):4151-9

Department of Experimental Therapeutics, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA.

Background: Spice and spice-derived compounds have been identified and explored for their health benefits since centuries. One of the spice long pepper has been traditionally used to treat chronic bronchitis, asthma, constipation, gonorrhea, paralysis of the tongue, diarrhea, cholera, malaria, viral hepatitis, respiratory infections, stomach ache, diseases of the spleen, cough, and tumors.

Methods: In this review, the evidences for the chemopreventive and chemotherapeutic potential of piperlongumine have been described. Read More

J Clin Rheumatol 2016 Jun;22(4):200-2

From the Department of Medicine, Rutgers-Robert Wood Johnson Medical School, New Brunswick, NJ.

In 1867, Alexandra, the 22-year-old Princess of Wales, late in her third pregnancy, had sudden onset of a febrile illness. There was a brief period of migratory arthritis, followed by persistent, severe inflammation in 1 knee. A diagnosis of rheumatic fever was made by her physicians, but the course of her illness differed greatly from the expected one. Read More

J Ethnopharmacol 2016 Apr 3;181:236-51. Epub 2016 Feb 3.

Pharmanza Herbal Pvt. Ltd., At post. Kaniya, District Anand 388430, India.

Ethnopharmacological Relevance: Symplocos racemosa Roxb. belongs to a unigeneric family Symplocaceae, known as lodhra in Sanskrit; is a small evergreen tree, found throughout the tropical and sub-tropical countries. Ethnobotanical literature indicates use of S. Read More

Reumatol Clin 2017 Jan - Feb;13(1):39-41. Epub 2016 Jan 27.

UGC de Enfermedades Infecciosas y Microbiología Clínica, Hospital Virgen de la Victoria, Málaga, España; Instituto de Biomedicina de Málaga (IBIMA), Málaga, España.

We report a case of gonococcal arthritis in a patient with human immunodeficiency virus (HIV) infection and review 17 previously published cases; only one patient presented urethritis, and blood cultures were positive in one case. Gonococcal arthritis is rare in HIV-infected patients and is not usually associated with other symptoms. It should be considered in the differential diagnosis of acute arthritis in patients with HIV infection. Read More

Clin Med (Lond) 2015 Oct;15(5):447-51

Great Western Hospitals NHS Foundation Trust, Swindon, UK

Adolescence is a time of sexual risk-taking and experimentation but also vulnerability. Young people may present to general physicians with systemic symptoms of sexually transmitted infections (STIs), such as arthritis, hepatitis or rash, but may not necessarily volunteer information about sexual activity. It is important for physicians to ask directly about sexual risks and if appropriate test for STIs and pregnancy. Read More

Int J STD AIDS 2016 09 16;27(10):882-9. Epub 2015 Sep 16.

Sydney Sexual Health Centre, Sydney Hospital, Sydney, NSW, Australia The Kirby Institute, UNSW Australia, Sydney, NSW, Australia

Reactive arthritis is an under-studied complication of genital Chlamydia trachomatis infection (chlamydia). We assessed trends and risk factors for reactive arthritis in a large urban sexual health clinic. Using a case-control design, data on reactive arthritis cases and controls at the Sydney Sexual Health Centre over the period 1992-2012 were extracted and multivariate analyses were performed. Read More

Int J STD AIDS 2016 May 6;27(6):490-3. Epub 2015 May 6.

Blackpool Sexual Health Services, Whitegate Health Centre, Blackpool, UK.

With recent increases in annual gonorrhoea incidence and disproportionately high infection rates amongst men who have sex with men, the clinical picture of disseminated gonococcal infection is changing. We present two cases where consideration of, and investigation for, disseminated Neisseria gonorrhoeae infection provided the answer when routine inpatient diagnostics had been unsuccessful. Read More

BMJ 2015 Apr 21;350:h1985. Epub 2015 Apr 21.

Sandyford Sexual Health Service, Glasgow G3 7NB, UK.

Sex Transm Infect 2015 Nov 19;91(7):497-501. Epub 2015 Mar 19.

Baker IDI Central Australia, Alice Springs Hospital, Alice Springs, Northern Territory, Australia Alice Springs Hospital, Alice Springs, Northern Territory, Australia School of Medicine, James Cook University, Cairns, Queensland, Australia.

Background: Disseminated Gonococcal Infection (DGI) is caused by Neisseria gonorrhoeae bacteraemia. Typically the primary source is a sexually acquired mucosal infection. If not recognised and treated promptly DGI can be associated with significant morbidity and, in rare cases, death. Read More

J Infect Dev Ctries 2014 Sep 12;8(9):1222-7. Epub 2014 Sep 12.

University of KwaZulu-Natal, Durban, South Africa.

Gonococcal urethritis is common with HIV, but gonococcal arthritis is rare. We report two HIV-positive patients with gonococcal arthritis and review previously published reports. A 27-year-old HIV-positive female presented with a pustular skin rash and acute oligoarthritis. Read More

Pan Afr Med J 2014 31;17:242. Epub 2014 Mar 31.

Rheumatology Department, Medical School, Sidi Mohammed Ibn Abdellah University, Hassan II University Hospital, Fez, Morocco.

Pregnancy is one of conditions that increase the risk of gonococcal arthritis which result from blood dissemination of neisseria gonorrhoeae. A 20-year-old africain female patient (in the second trimester of pregnancy), was admitted to hospital because of fever, asymmetric joint swollen affecting the hands, wrists, left ankle, and right sternoclavicular joint. Laboratory findings (erythrocyte sedimentation rate was 117 mm in first hour, The serum C-reactive protein level was 152 mg/L) the gram stain of genital sample was positif of neisseria gonorrhoeae and trichomonas vaginalis. Read More

Int J STD AIDS 2015 Mar 14;26(3):139-44. Epub 2014 May 14.

Department of Rheumatology, Northwick Park Hospital, Middlesex, UK.

There are problems in attributing causality in inflammatory arthritis. So far as C. trachomatis and sexually acquired reactive arthritis are concerned, there is much in favour of a causal relationship, although there are important caveats which need to be explored before it is possible to say unreservedly that C. Read More

Clin Rheumatol 2014 Sep 29;33(9):1351-3. Epub 2014 Apr 29.

Infectious Diseases, Raymond Poincaré Teaching Hospital, Garches, 92380, France,

Gonococcal arthritis is typically acute and appears within 3 weeks after initial infection. Chronic gonococcal arthritis is now exceptionally rare, since the advent of the antibiotic era. Numerous host factors are involved in gonococcal dissemination, such as complement deficiency, HIV and gonococcus strain characteristics. Read More

Ann Emerg Med 2014 May;63(5):528, 571

University of California at San Francisco, San Francisco, CA; San Francisco General Hospital, San Francisco, CA.

Clin Dermatol 2014 Mar-Apr;32(2):196-208

STI Outpatient Clinic, Cluster of Infectious diseases, Public Health Service Amsterdam, Amsterdam, The Netherlands; Department of Dermatology, Academic Medical Center, Post Office Box 22700, 1100 DE, University of Amsterdam, Amsterdam, The Netherlands; Centre for Infection and Immunity Amsterdam (CINIMA) Academic Medical Centre University of Amsterdam, Amsterdam, The Netherlands; Centre for Infectious Diseases Control; National Institute for Public Health and the Environment (CIb/RIVM), Bilthoven, The Netherlands. Electronic address:

Cutaneous signs and skin conditions associated with sexually transmitted infections (STIs) are discussed. Syphilis, condyloma acuminata, and scabies are well-known STIs with cutaneous manifestations. Chlamydia and gonorrhea can also cause specific muco-cutaneous signs and symptoms. Read More

Lupus 2014 10;23(1):81-3. Epub 2013 Oct 10.

1Department of Internal Medicine, Centre Hospitalier Lyon Sud, Pierre Benite, France.

Gonorrhea is a common sexually transmitted infection, which can present as the 'arthritis-dermatitis syndrome'. Patients with systemic lupus erythematosus often develop disseminated neisserial infections, because of inherited and acquired complement deficiencies. Neisserial infection, and particularly gonococcemia, can mimic a lupus flare. Read More

Clin Pediatr (Phila) 2013 Oct 5;52(10):991-3. Epub 2013 Aug 5.

1Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.

Sex Transm Infect 2013 Dec 6;89(8):613-5. Epub 2013 Aug 6.

Department of Infectious and Tropical Diseases, Centre Hospitalier Intercommunal, , Villeneuve Saint Georges, France.

Objectives: Disseminated gonococcal infections (DGIs) are rare. We describe the characteristics of DGIs in France.

Methods: This is a 3-year retrospective analysis of DGI cases collected through two networks of microbiologists and infectious disease specialists in France between 2009 and 2011. Read More

J Ethnopharmacol 2013 Jun 3;147(3):547-63. Epub 2013 Apr 3.

Department of Pharmacognosy, School of Pharmacy, Second Military Medical University, 325 Guohe Road, Shanghai 200433, China.

Ethnopharmacological Relevance: In the genus Curculigo, Curculigo orchioides Gaertn, Curculigo capitulata (Lour) O. Ktze and Curculigo pilosa (Schumach. & Thonn. Read More

Arch Pediatr Adolesc Med 2012 Nov;166(11):1065-6

Department of Pediatric Infectious Diseases, Children’s Hospital of Philadelphia, Philadelphia, PA 19104, USA.

Case Rep Infect Dis 2012 5;2012:790478. Epub 2012 Aug 5.

Division of Infectious Disease and Tropical Medicine, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand.

Disseminated gonococcal infection (DGI) is an uncommon complication of Neisseria gonorrhoeae infection, its manifestation varies from a classic arthritis-dermatitis syndrome to uncommon pyogenic infections of several organs. Herein, we reported atypical presentation of DGI with subcutaneous abscess of right knee, pyomyositis of right lower extremity, and subsequently complicated by Escherichia coli pyomyositis. This infection responded to appropriate antimicrobial therapy and prompt surgical management with good clinical outcome. Read More

Pharmacogn Rev 2012 Jan;6(11):68-73

Department of Pharmaceutics, Institute of Technology, Banaras Hindu University, Varanasi, India.

Medicinal plants are widely being used by the traditional medical practitioners for curing various diseases in their day-to-day practice. Biophytum sensitivum DC (Oxalidaceae) is used as a traditional folk medicine in ailments such as inflammation, arthritis, wounds, tumors and burns, gonorrhea, stomach ache, asthma, cough, degenerative joint disease, urinary calculi, diabetes, snake bite, amenorrhea and dysmenorrhea. It is a small, flowering, annual herb with sensitive leaves. Read More

West Indian Med J 2011 Dec;60(6):688-9

Division of Orthopaedics, Department of Surgery, Faculty of Medical Sciences, The University of the West Indies, Kingston 7, Jamaica, West Indies.

Joint Bone Spine 2012 Oct 13;79(5):519-20. Epub 2012 Apr 13.

Obstet Gynecol 2012 Mar;119(3):597-602

Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75235-9032, USA.

Objective: To review the clinical presentation, complications, and response to treatment of pregnant and nonpregnant women admitted for management of disseminated gonococcal infection over a 34-year period.

Methods: This was a review of all women diagnosed with disseminated gonococcal infection who were admitted to Parkland Memorial Hospital from 1975 through 2008. Medical records were reviewed and data extracted that included demographic information, clinical and laboratory findings, and response to antimicrobial treatment. Read More

Singapore Med J 2012 Feb;53(2):e38-9

Section of Plastic, Reconstructive and Aesthetic Surgery, Department of General Surgery, National University Health System, 1E Kent Ridge Road, Singapore.

Gonococcal infection is a common sexually-transmitted infection in the older male population in our local setting. It is caused by Neisseria gonorrhoeae, and results in fever, dysuria and a foul-smelling discharge from the external urethral meatus. Occasionally, it may also present with disseminated gonococcal infection - dermatitis, septic arthritis and even meningitis or endocarditis. Read More

Arthritis Care Res (Hoboken) 2012 Feb;64(2):298-302

Dartmouth Medical School and Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire 03756, USA.

Best Pract Res Clin Rheumatol 2011 Jun;25(3):407-21

Rheumatology Unit, La Paz University Hospital, Paseo de la Castellana 261, 28046 Madrid, Spain.

This article presents a review of the current approach to diagnostic and therapeutic conditions of septic arthritis. Acute septic arthritis is an uncommon, but potentially fatal, emergency. Early diagnosis as well as prompt and effective treatment are essential to avoid either irreversible joint destruction or even death. Read More

J Ayurveda Integr Med 2010 Jul;1(3):183-9

Ayurveda Regional Research Institute, Tadong, Gangtok, Sikkim - 737 102, India.

Ancient medical systems are still prevalent in Sikkim, popularly nurtured by Buddhist groups using the traditional Tibetan pharmacopoeia overlapping with Ayurvedic medicine. Traditional medical practices and their associated cultural values are based round Sikkim's three major communities, Lepcha, Bhutia and Nepalis. In this study, a semi-structured questionnaire was prepared for folk healers covering age and sex, educational qualification, source of knowledge, types of practices, experience and generation of practice, and transformation of knowledge. Read More

Heart Lung 2012 Mar-Apr;41(2):177-80. Epub 2011 Mar 30.

Infectious Disease Division, Winthrop-University Hospital, Mineola, New York 11501, USA.

Background: Fever of unknown origin (FUO) has been defined as a fever of ≥101°F that persists for 3 weeks or more. It is not readily diagnosed after 1 week of intensive in-hospital testing or after intensive outpatient or inpatient testing. Fevers of unknown origin may be caused by infectious diseases, malignancies, collagen vascular diseases, or a variety of miscellaneous disorders. Read More

Ned Tijdschr Geneeskd 2011 ;155:A2250

TweeSteden ziekenhuis, Afd. Interne Geneeskunde, Tilburg, The Netherlands.

Disseminated gonococcal infection occurs in less than 5% of patients infected with Neisseria gonorrhoeae. The majority of these patients present with arthritis, tenosynovitis, polyarthralgia or dermatitis. In this article we present two patients with disseminated gonococcal infection, each with different symptoms. Read More

Afr J Tradit Complement Altern Med 2011 2;8(3):267-74. Epub 2011 Apr 2.

Department of Microbiology, Federal University of Technology, Akure, Nigeria.

For centuries, mushrooms have been appreciated as sources of food nutrients and pharmacologically important compounds useful in medicine. Yet not all the medicinal properties of mushrooms have been exploited. The above statement is more pertinent to mushrooms that are indigenous to Nigeria. Read More

Prim Care 2010 Dec;37(4):713-27, vi

Hinsdale Family Medicine Residency, Hinsdale, IL, USA.

About 15% of patients presenting in a primary care clinic have joint pain as their primary complaint (level B). Disseminated gonorrhea is the most common cause of infectious arthritis in sexually active, previously healthy patients (level B). Prompt arthrocentesis, microscopic examination, and the culture of any purulent material plus appropriate antibiotic therapy are the mainstay of treatment in infectious arthritis (level C). Read More