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    The Concomitant Association of Thyroid Disorders and Myasthenia Gravis.
    Transl Neurosci 2017 30;8:27-30. Epub 2017 Apr 30.
    Division of Endocrinology and Metabolism, Department of Internal Medicine, Taipei Medical University Hospital, Taipei, Taiwan.
    Background: Some of the thyroid disorders (TD) and Myasthenia gravis (MG) are autoimmune related disease. The purpose of the study to evaluate the relationship of MG with all morphological and functional thyroid disorders.

    Methods: We constructed a population-based cohort study during the period from January 2000-December 2002 by using reimbursement data from the Bureau National Health Insurance (NHI) system in Taiwan. Read More

    Subclinical Hyperthyroidism: When to Consider Treatment.
    Am Fam Physician 2017 Jun;95(11):710-716
    Allegheny Health Network, Pittsburgh, PA, USA.
    Subclinical hyperthyroidism is defined by a low or undetectable serum thyroid-stimulating hormone level, with normal free thyroxine and total or free triiodothyronine levels. It can be caused by increased endogenous production of thyroid hormone (e.g. Read More

    Retrograde Thyroidectomy for preservation of the External Branch of the Superior Laryngeal Nerve: A case series.
    Int J Surg Case Rep 2017 May 15. Epub 2017 May 15.
    Department of Clinical Surgical Sciences, The University of West Indies, St Augustine, Trinidad and Tobago.
    Background: The external branch of the Superior Laryngeal nerve (EBSLN) is at high risk of injury in surgery for large multinodular goitre (MNG) since the upper pole is high in the neck, well cephalad to the EBSLN. We present a technique of drawing the lobe caudally by retrograde thyroidectomy in order to minimize nerve injury.

    Design & Method: All patients having surgery for benign MNG were included. Read More

    Study of factors that influence the outcome of (131)I treatment in hyperthyroidism secondary to nodular goitre.
    Rev Esp Med Nucl Imagen Mol 2017 Jun 12. Epub 2017 Jun 12.
    Servicio de Medicina Interna, Hospital POVISA, Vigo, España.
    Objective: To assess the outcome after (131)I treatment in patients with multinodular (MNG) and nodular toxic goitre (NTG) according to the administered dose and other factors related to the patient, pathology, or previous treatments.

    Material And Methods: A retrospective study was conducted on 108 patients (67 MNG and 41 NTG) treated in our department, with a follow-up period of at least 2 years. Development of hypothyroidism and treatment failure were evaluated along with their relationship with the administered dose and other factors such as age, sex, grade of hyperthyroidism, type of goitre, presence of autoimmunity, or previous antithyroid medication. Read More

    Thyrotoxicosis - investigation and management .
    Clin Med (Lond) 2017 Jun;17(3):274-277
    King's College Hospital, Denmark Hill, London
    Graves' disease (GD) and toxic nodular (TN) goitre account for most cases of thyrotoxicosis associated with hyperthyroidism. Hyperthyroidism is confirmed with measurement of a suppressed serum thyrotropin concentration (TSH) and elevated free thyroid hormones. The three therapeutic options are antithyroid drugs, radioactive iodine and surgery. Read More

    Increased Cardiovascular Mortality and Morbidity in Patients Treated for Toxic Nodular Goiter Compared to Graves' Disease and Nontoxic Goiter.
    Thyroid 2017 Jul 5;27(7):878-885. Epub 2017 Jun 5.
    6 Department of Clinical Research and Education, Sodersjukhuset, Karolinska Institutet , Stockholm, Sweden .
    Background: Previous research has suggested an increased risk of death and cardiovascular disease in patients treated for hyperthyroidism. However, studies on this subject are heterogeneous, often based on old data, or have not considered the impact that treatment for hyperthyroidism might have on cardiovascular risk. It is also unclear whether long-term prognosis differs between Graves' disease and toxic nodular goiter. Read More

    New Daily Persistent Headache Caused by a Multinodular Goiter and Headaches Associated With Thyroid Disease.
    Headache 2017 Feb 27;57(2):285-289. Epub 2016 Dec 27.
    Neuroradiology Private Practice.
    A 33-year-old female is presented with the first case to our knowledge of new daily persistent headache (NDPH) with a large right benign non-toxic multinodular goiter causing carotid and vertebral compression with complete resolution of the headache immediately after thyroidectomy. Although this may be quite rare, hypothyroidism or hyperthyroidism causing NDPH, migraine, or an exacerbation of pre-existing migraine is not. Clinicians should consider routinely obtaining serum thyroid-stimulating hormone (TSH) and free T4 in patients with new onset frequent headaches or an exacerbation of prior primary headaches. Read More

    Thyroid Peroxidase Antibodies in Non-Autoimmune Hyperthyroidism Treated with Radioactive Iodine.
    Exp Clin Endocrinol Diabetes 2016 Oct 13;124(9):572-576. Epub 2016 Oct 13.
    Department of Nuclear Medicine, Pomeranian Medical University, Szczecin, Poland.
    Introduction: Earlier studies suggest increased serum levels of thyroid peroxidase antibodies (TPOAb) in some cases with non-autoimmune hyperthyroidism. The aim of the study was to assess the incidence of hypothyroidism in patients with nodular toxic goitre and toxic adenoma at 12 months after radioactive iodine therapy in the relation to TPOAb levels. Patients & Measurements: The study comprised 100 patients (83 females; 17 males) treated with radioactive iodine therapy. Read More

    A Novel Germline Mutation of KEAP1 (R483H) Associated with a Non-Toxic Multinodular Goiter.
    Front Endocrinol (Lausanne) 2016 20;7:131. Epub 2016 Sep 20.
    Center for Excellence in Thyroid Care, Kuma Hospital , Kobe , Japan.
    Background: A germline mutation of KEAP1 gene was reported as a novel genetic abnormality associated with familial multinodular goiter. That report was limited, and the pathogenic features were not well established.

    Patient Findings: We report a 47-year-old Japanese woman who presented with hyperthyroidism and a large multinodular goiter. Read More

    Vitamin D status in Egyptian euthyroid multinodular non-toxic goiter patients and its correlation with TSH levels.
    Endocrinol Nutr 2016 Oct 21;63(8):380-6. Epub 2016 Aug 21.
    Clinical Pathology, Faculty of Medicine, Mansoura University, Mansoura, Egypt.
    Background And Aim: Although the prevalence of MNG is widespread throughout the world, its pathogenesis is poorly understood, and the complex interactions of both genetic predisposition and the individuals' environment are likely. However, to the best of our knowledge, it remains unknown whether there is a relationship between vitamin D status and prevalence or pathogenesis of euthyroid MNG. Therefore, the goal of the present study was determination of vitamin D status in euthyroid MNG as well as exploration of the correlation between vitamin D status & TSH levels. Read More

    Graves Disease Induced by Radioiodine Therapy for Toxic Nodular Goiter: A Case Report.
    Mol Imaging Radionucl Ther 2015 Oct;24(3):135-7
    Adnan Menderes University Faculty of Medicine, Department of Nuclear Medicine, Aydın, Turkey Phone: +90 256 444 12 56 E-mail:
    Graves' disease (GD) may be observed as an infrequent adverse effect after radioiodine therapy (RAIT) for toxic thyroid adenoma (TA) and toxic multi nodular goiter (MNG). We present a case of a 55-year-old male with a toxic nodule who was treated with RAI. After therapy, the patient's serum free triiodothyronine (fT3) and free thyroxine (fT4) levels gradually increased. Read More

    Effectiveness of Radioiodine Treatment for Toxic Nodular Goiter.
    Mol Imaging Radionucl Ther 2015 Oct;24(3):100-4
    Adnan Menderes University Faculty of Medicine, Department of Nuclear Medicine, Aydın, Turkey Phone: +90 256 444 12 56 E-mail:
    Objective: The aim of this retrospective study is to evaluate the treatment outcomes in patients with toxic nodular goiter (TNG) that received radioiodine treatment (RAIT) and to determine the influence of age, gender, nodule size, I-131 dose, underlying etiology and antithyroid drugs on the outcomes of RAIT.

    Methods: Two hundred thirty three patients (mean 64±10 years old) with TNG that received RAIT were included in the study. Treatment success was analyzed according to demographic (age and gender) and clinical data (thyroid function tests before and after RAIT, thyroid sonography and scintigraphy, I-131 dose, antithyroid drugs). Read More

    Long-Term Results of Fixed High-Dose I-131 Treatment for Toxic Nodular Goiter: Higher Euthyroidism Rates in Geriatric Patients.
    Mol Imaging Radionucl Ther 2015 Oct;24(3):94-9
    Trakya University Faculty of Medicine, Department of Nuclear Medicine, Edirne, Turkey Phone: +90 284 235 76 41-10 42 E-mail:
    Objective: Geriatric patient population has special importance due to particular challenges. In addition to the increase in incidence of toxic nodular goiter (TNG) with age, it has a high incidence in the regions of low-medium iodine intake such as in our country. The aim of this study was to evaluate the overall outcome of high fixed dose radioiodine (RAI) therapy, and investigate the particular differences in the geriatric patient population. Read More

    Is the TSHR D727E polymorphism a genetic predisposition for multinodular goiter in the Turkish population?
    Genet Mol Res 2016 Aug 5;15(3). Epub 2016 Aug 5.
    Division of Biology, Department of Molecular Biology and Genetics, Faculty of Arts and Sciences, Namık Kemal University, Tekirdag, Turkey
    The D727E germline polymorphism in the thyroid-stimulating hormone receptor gene (TSHR) may cause genetic susceptibility to the development of goiter. Therefore, in this study we investigated allele frequencies and genotype distributions of the TSHR D727E polymorphism, their association with clinical parameters, and the development of goiter in the Turkish population. We investigated the TSHR D727E polymorphism in 123 patients and 97 healthy subjects using the polymerase chain reaction-restriction fragment length polymorphism technique. Read More

    Managing thyroid disease in general practice.
    Med J Aust 2016 Aug;205(4):179-84
    Sir Charles Gairdner Hospital, Perth, WA
    Serum thyroid-stimulating hormone (TSH) testing is the best screening tool for thyroid dysfunction. When TSH levels are in the reference range, additional tests such as free thyroxine, free triiodothyronine or thyroid antibodies rarely add value, except in patients with pituitary disease, when TSH is unreliable. Overt hypothyroidism and subclinical hypothyroidism with TSH levels > 10 mU/L can be treated without further investigation. Read More

    Is there a group of patients at greater risk for hematoma following thyroidectomy? A systematic review and meta-analysis.
    Laryngoscope 2017 Jun 2;127(6):1483-1490. Epub 2016 Aug 2.
    Department of Otolaryngology-Head and Neck Surgery, University of Ottawa, Ontario, Canada.
    Objective: The purpose of this study was to perform a systematic review and meta-analysis to determine whether a difference exists in hematoma rates following thyroidectomy for any of the following subgroups of patients: Graves disease, toxic nodular goiter (TNG), and malignancy.

    Study Design: Systematic review and meta-analysis.

    Methods: A systematic literature search was performed for all relevant English and French language studies (1946-2015) using Ovid MEDLINE, EMBASE, and PubMed. Read More

    Recombinant human thyrotropin stimulated (131)I treatment for multinodular goiter.
    Nuklearmedizin 2016 Dec 2;55(6):228-235. Epub 2016 Aug 2.
    Dr. Fengyu Wu, Haier Road 59, Qingdao 266003, China, E-Mail:
    The aim of the study was to investigate the effects of rhTSH stimulation before (131)I treatment in patients with MNG.

    Methods: Sources included the Cochrane Library, MEDLINE, EMBASE, and SCOPUS database (all until January 2016). Randomized controlled trials (RCTs) that assessed the efficacy of rhTSH-stimulated (131)I treatment compared to placebo or (131)I treatment alone were collected. Read More

    Quality-of-Life Impairments Persist Six Months After Treatment of Graves' Hyperthyroidism and Toxic Nodular Goiter: A Prospective Cohort Study.
    Thyroid 2016 Aug;26(8):1010-8
    1 Department of Medical Endocrinology, Copenhagen University Hospital Rigshospitalet , Copenhagen, Denmark .
    Background: The treatment of hyperthyroidism is aimed at improving health-related quality of life (HRQoL) and reducing morbidity and mortality. However, few studies have used validated questionnaires to assess HRQoL prospectively in such patients. The purpose of this study was to assess the impact of hyperthyroidism and its treatment on HRQoL using validated disease-specific and generic questionnaires. Read More

    Transcriptional activity of TGFβ1 and its receptors genes in thyroid gland.
    Endokrynol Pol 2016 27;67(4):375-82. Epub 2016 Jun 27.
    Department of Pathophysiology and Endocrinology, School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia, Katowice.
    Introduction: Determination of gene-candidates' profile expression responsible for fibrosis, immunosuppression, angiogenesis, and neoplasia processes in the pathogenesis of thyroid gland disease.

    Material And Methods: Sixty-three patients underwent thyroidectomy: 27 with non-toxic nodular goitre (NG), 22 with toxic nodular goitre (TNG), six with papillary cancer (PTC), and eight with Graves' disease (GD). In thyroid tissues, transcriptional activity of TGFbeta1 and its receptors TGFbetaRI, TGFbetaRII, and TGFbetaRIII genes were assessed using RT-qPCR (Reverse Transcriptase Quantitative Polymerase Chain Reaction). Read More

    Hyperthyroidism in patients with thyroid cancer.
    Ear Nose Throat J 2016 Jun;95(6):236-9
    Department of Otorhinolaryngology, Queens Hospital, Rom Valley Way, Romford, Essex RM7 0AG, UK.
    We present a retrospective case series of patients with hyperthyroidism and thyroid cancer. Our goal was to look at their clinical characteristics and outcomes to determine which patients would require further investigation. We reviewed the case notes of all patients with a histopathologic diagnosis of thyroid cancer and biochemical evidence of hyperthyroidism who had been treated at a thyroid cancer center from January 2006 through October 2013. Read More

    Hyperthyroidism.
    Lancet 2016 Aug 30;388(10047):906-918. Epub 2016 Mar 30.
    Endocrine Unit, Fondazione IRCCS Cà Granda, Milan, Italy (S De Leo MD); Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy (S De Leo); and Section of Endocrinology, Diabetes and Nutrition, Boston University School of Medicine, Boston, MA, USA (S De Leo, S Y Lee MD, Prof L E Braverman MD).
    Hyperthyroidism is characterised by increased thyroid hormone synthesis and secretion from the thyroid gland, whereas thyrotoxicosis refers to the clinical syndrome of excess circulating thyroid hormones, irrespective of the source. The most common cause of hyperthyroidism is Graves' disease, followed by toxic nodular goitre. Other important causes of thyrotoxicosis include thyroiditis, iodine-induced and drug-induced thyroid dysfunction, and factitious ingestion of excess thyroid hormones. Read More

    [AUTOIMMUNE REACTIONS IN PATIENTS WITH DISEASES OF A THYROID GLAND].
    Klin Khir 2015 Nov(11):51-3
    A state of autoimmunity was studied in 25 patients, suffering diffuse toxic goiter (DTG), and in 20--in nodular euthyroid goiter (NEG) before and after the operation. The level of circulating immune complexes, quantity of cytotoxic lymphocytes, the subpopulation index, the apoptosis marker were determined. There was established, that in NEG autoimmune disorders have occurred rarer and were less severe, than in DTG. Read More

    Single, very low dose (0.03 mg) of recombinant human thyrotropin (rhTSH) effectively increases radioiodine uptake in the I-131 treatment of large nontoxic multinodular goiter.
    Nucl Med Rev Cent East Eur 2016 ;19(1):3-11
    Nuclear Medicine Department, Medical University of Bialystok, Poland.
    Background: Radioiodine therapy (RIT) in patients with large nontoxic multinodular goiter (MNG) recently becomes more common method in comparison to surgery (especially in elderly patients and with contraindications because of severe chronic diseases other systems). Repeatedly low thyroid radioactive iodine uptake (RAIU) decreases effectiveness of RIT or makes it impossible. The recombinant human thyrotropin can increase RAIU and improve the results of RIT. Read More

    [ANALYSIS OF ULTRASONIC, CYTOLOGICAL AND MORPHOLOGIC RESEARCHES RESULTS OF PATIENTS WITH GRAVES' DISEASE (TOXIC GOITER) DEPENDING ON DISEASE DURATION].
    Lik Sprava 2015 Apr-Jun(3-4):115-20
    The aim of research is to arrange the results of ultrasonic and cytological researches during long-term drug treatment (more than 1 year) of patients with Graves' disease. From 2008 to 2013 the detailed examination of 220 patients was carried out in Kyiv City Centre for Endocrine Surgery which operates on the basis of the 3d Clinical Hospital. There were established three kinds of echographic patterns which pointed out the ultrasonic changes of the thyroid gland tissue, occurred during the drug treatment. Read More

    [Changes in radioiodine therapy for thyroid disorders].
    Orv Hetil 2016 Jan;157(3):83-8
    Belgyógyászati Osztály és Izotóp Részleg, Jávorszky Ödön Kórház Vác.
    Radioiodine therapy for benign and malignant thyroid diseases was introduced about 70 years ago, however, there is still a lack of consensus regarding indications, doses and procedure. This review covers treatment results in immunogenic hyperthyroidism including the problem of orbitopathy. Radioiodine therapy for toxic and non-toxic multinodular goiter is also discussed with striking possibility of enhanching the radioiodine uptake. Read More

    Non cancer thyroid and other endocrine disease in children and adults exposed to ionizing radiation after the ChNPP accident.
    Probl Radiac Med Radiobiol 2015 Dec;20:341-55
    State Institution National Research Center for Radiation Medicine of National Academy of MedicalSciences of Ukraine, Melnikova str., 53, Kyiv, 04050, Ukraine.
    Study Objective: To summarize the verified clinical and epidemiological data on the natural history of non cancer endocrine disease in remote period after the ChNPP accident in survivors of adult and children age.

    Materials And Methods: Retrospective estimation was carried out of data on 24,588 adult persons and 20,087 chil dren survived after the ChNNP accident and being healthy or having any diseases. Data were retrieved from database of the Clinical Epidemiological Registry (CER), NRCRM for the 23 years (1992-2014) of survey. Read More

    Organ Dose Estimates for Hyperthyroid Patients Treated with (131)I: An Update of the Thyrotoxicosis Follow-Up Study.
    Radiat Res 2015 Dec 18;184(6):595-610. Epub 2015 Nov 18.
    a  Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892;
    The Thyrotoxicosis Therapy Follow-up Study (TTFUS) is comprised of 35,593 hyperthyroid patients treated from the mid-1940s through the mid-1960s. One objective of the TTFUS was to evaluate the long-term effects of high-dose iodine-131 ((131)I) treatment (1-4). In the TTFUS cohort, 23,020 patients were treated with (131)I, including 21,536 patients with Graves disease (GD), 1,203 patients with toxic nodular goiter (TNG) and 281 patients with unknown disease. Read More

    TREATMENT OF SUBCLINICAL HYPERTHYROIDISM: EFFECT ON BODY COMPOSITION.
    Nutr Hosp 2015 Nov 1;32(5):2331-7. Epub 2015 Nov 1.
    Hospital Universitario Miguel Servet, Department of Nuclear Medicine. Spain..
    Background: subclinical hyperthyroidism (SHT) is associated with harmful effects on cardiovascular system, bone metabolism and progression to clinical hyperthyroidism. Loss of weight is a common fact in patients with clinical hyperthyroidism and of particular relevance in elderly patients.

    Objective: to assess changes in body composition after radioiodine therapy for SHT due to toxic nodular goiter. Read More

    Robot-assisted laparoscopic (RAL) procedures in general surgery.
    Int J Med Robot 2016 Sep 6;12(3):427-30. Epub 2015 Oct 6.
    Umraniye Research and Training Hospital, Department of Surgery, Istanbul, Turkey.
    Background: Robotics was introduced in clinical practice more than two decades ago, and it has gained remarkable popularity for a wide variety of laparoscopic procedures. We report our results of robot-assisted laparoscopic surgery (RALS) in the most commonly applied general surgical procedures.

    Method: Ninety seven patients underwent RALS from 2009 to 2012. Read More

    Hyperthyroidism is associated with work disability and loss of labour market income. A Danish register-based study in singletons and disease-discordant twin pairs.
    Eur J Endocrinol 2015 Nov 24;173(5):595-602. Epub 2015 Sep 24.
    Department of Endocrinology and MetabolismElite Endocrine Research Centre, Odense University Hospital, Sønder Boulevard 29, DK-5000 Odense C, Denmark.
    Objective: To examine the risk of disability pension and changes in labour market income in patients with hyperthyroidism.

    Methods: From a 5% random sample of the Danish population and twins from the Danish Twin Registry we identified 1942 hyperthyroid singletons and 7768 non-hyperthyroid (matched 1:4) controls as well as 584 same-sex twin pairs discordant for hyperthyroidism. Singletons and twins were followed for a mean of 9 years (range 1-20). Read More

    Etiopathology, clinical features, and treatment of diffuse and multinodular nontoxic goiters.
    J Endocrinol Invest 2016 Apr 21;39(4):357-73. Epub 2015 Sep 21.
    Thyroid Unit, Division of Endocrinology and Metabolism, Hospital das Clínicas, University of São Paulo Medical School, Av. Dr. Enéas de Carvalho Aguiar, 155 - 8th floor, bl 3, PAMB, São Paulo, 05403-900, Brazil.
    Goiter, an enlargement of the thyroid gland, is a common problem in clinical practice associated with iodine deficiency, increase in serum thyroid-stimulating hormone (TSH) level, natural goitrogens, smoking, and lack of selenium and iron. Evidence suggests that heredity also has an important role in the etiology of goiter. The current classification divides goiter into diffuse and nodular, which may be further subdivided into toxic (associated with symptoms of hyperthyroidism, suppressed TSH or both), or nontoxic (associated with a normal TSH level). Read More

    Non-Recurrent Laryngeal Nerve.
    Pol Przegl Chir 2015 Jul;87(7):336-9
    Unlabelled: The aim of the study was to assess the frequency of non-recurrent laryngeal nerves (Non-RLN).

    Material And Methods: A total of 6110 patients were operated in our hospital between 1 January 2005 and 31 December 2013 for various goiters (5429) and various types of hyperparathyroidism (618). Laryngeal nerve was exposed during operation in 1700 patients from superior aperture of the chest to superior aperture of the larynx. Read More

    Postoperative Acute Respiratory Failure In Patients Treated Surgically For Goiters.
    Pol Przegl Chir 2015 Jul;87(7):331-5
    Unlabelled: The aim of the study was to present a clinical picture, treatment and prognosis regarding patients who developed acute respiratory failure (ARF) while treated surgically for a goiter.

    Material And Methods: A total of 3810 patients were treated for goiters between 2008 to 2013. Symptoms of postoperative ARF were recognized in 39 (1%) patients. Read More

    Cardiothyreosis: Pathogenic Conjectures, Clinical Aspects and Surgical Approach.
    Chirurgia (Bucur) 2015 Jul-Aug;110(4):333-8
    Introduction: The presence of striking cardiovascular manifestations were noted in the first descriptions of hyperthyroidism owing to Parry (1825) and Basedow (1840) in his famous Merseburg triad. Hyperthyroidism may either cause cardiac complications in individuals with a normal myocardium (genuine form of disorder) or complicate preexisting cardiac troubles.

    Material And Method: An homogenous series of 49 cardiothyreosis, 11 males and 38 females, aged 12 - 78 (mean 45) years selected between 138 thyrotoxic patients operated on in a period of two decades is herein presented. Read More

    Lipid peroxidation and antioxidants status in human malignant and non-malignant thyroid tumours.
    Hum Exp Toxicol 2016 Jun 12;35(6):585-97. Epub 2015 Aug 12.
    Department of Endocrinology, Dr ALM Post Graduate Institute of Basic Medical Sciences, University of Madras, Taramani, Chennai, Tamil Nadu, India.
    Introduction: Thyroid epithelial cells produce moderate amounts of reactive oxygen species that are physiologically required for thyroid hormone synthesis. Nevertheless, when they are produced in excessive amounts, they may become toxic.

    Objective: The present study is aimed to compare the lipid peroxidation (LPO), antioxidant enzymes - superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and non-protein thiols (reduced glutathione (GSH)) in human thyroid tissues with malignant and non-malignant disorders. Read More

    Total or near-total thyroidectomy versus subtotal thyroidectomy for multinodular non-toxic goitre in adults.
    Cochrane Database Syst Rev 2015 Aug 7(8):CD010370. Epub 2015 Aug 7.
    Department of General Surgery, University of Perugia, Terni, Italy, 05100.
    Background: Total thyroidectomy (TT) and subtotal thyroidectomy (ST) are worldwide treatment options for multinodular non-toxic goitre in adults. Near TT, defined as a postoperative thyroid remnant less than 1 mL, is supposed to be a similarly effective but safer option than TT. ST has been shown to be marginally safer than TT, but it may leave an undetected thyroid cancer in place. Read More

    Propylthiouracil induced pulmonary-renal syndrome: a case report.
    Acta Reumatol Port 2015 Apr-Jun;40(2):190-2
    Propylthiouracil (PTU) is known to induce antineutrophil cytoplasmatic antibody (ANCA) seropositivity; however, small vessel vasculitis (SVV) with pulmonary and renal involvement is rare. We present the case of an 81-year-old woman on PTU treatment due to toxic nodular goitre who developed alveolar hemorrhage and rapidly progressive glomerulonephritis. The authors highlight the importance of early recognising drug-induced pulmonary-renal syndrome (PRS) in order to avoid unnecessary tests, a delay in the diagnosis and evolution to end-stage kidney disease or life-threatening conditions. Read More

    Is hemithyroidectomy a rational management for benign nodular goitre? A Multicentre Retrospective Single Group Study.
    Neth J Med 2015 Jan;73(1):17-22
    Department of General Surgery, Marmara University School of Medicine, Istanbul, Turkey, Department of Surgery, Ankara Training and Research Hospital, Ankara, Turkey, Department of General Surgery, Kocaeli University School of Medicine, Kocaeli, Turkey, Istanbul Faculty of Medicine, Surgery Unit E, Istanbul University, Istanbul, Turkey, Department of General Surgery, Gulhane Military Medical Academy, Ankara, Turkey, Department of Surgery, Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, Turkey, Department of General Surgery, Dokuz Eylul University School of Medicine, Izmir, Turkey, Department of General Surgery, Maltepe University School of Medicine, Istanbul, Turkey, Department of General Surgery, Adnan Menderes University School of Medicine, Aydin, Turkey, *corresponding author: tel.: +90 2166570606, fax: +90 2166570695, email:
    Background: The incidence and potential risk factors for the recurrence of benign nodular goitre after unilateral thyroidectomy are not clearly defined. The aim of this study was to assess the rate of progression of nodular goitre in the contralateral thyroid lobe and of hypothyroidism requiring replacement therapy after unilateral thyroid lobectomy for benign nodular goitre.

    Patients And Methods: Patients who underwent hemithyroidectomy for benign nodular goitre between 2000 and 2009 were included in the study. Read More

    B Cell Activating Factor (BAFF) and BAFF Receptor Expression in Autoimmune and Nonautoimmune Thyroid Diseases.
    Thyroid 2015 Sep 13;25(9):1043-9. Epub 2015 Aug 13.
    1 Graves' Orbitopathy Center , Endocrinology Unit, Department of Clinical Sciences and Community Health, Ospedale Maggiore Policlinico of Milan and Università degli Studi di Milano , Milan, Italy .
    Background: The B cell activating factor (BAFF) is a member of the tumor necrosis factor family, which controls the survival/proliferation of B cells and is involved in the pathogenesis of a number of autoimmune diseases. The objective of the present study was to investigate the expression of BAFF and BAFF receptor (BAFF-R) in the thyroid tissue of patients affected with autoimmune thyroid disorders (AITD) or multinodular goiter (MNG) compared with those with normal thyroids.

    Methods: Immunohistochemistry was performed using a panel of antibodies against BAFF, BAFF-R, CD3, CD4, CD8, CD20, CD34, CD79a, CD1a, CD68, and CD163 on the thyroid sections of 27 patients affected with Graves' disease (GD), 23 with Hashimoto's thyroiditis (HT), 16 with nontoxic nodular goiter (NTG), and 15 with toxic nodular goiter (TG), submitted to total thyroidectomy between 2000 and 2011. Read More

    Marine-Lenhart syndrome with papillary thyroid carcinoma.
    J Res Med Sci 2015 Apr;20(4):412-5
    Department of Nuclear Medicine, Ondokuz Mayis University Medical School, Samsun, Turkey.
    Graves' disease with accompanying functioning nodules is known as Marine-Lenhart syndrome. Autonomously functioning thyroid nodules (AFTNs) also within Graves' thyroid tissue are almost always bening in nature. A 45-year-old man developed hyperthyroidism due to the coexistence of Graves' disease and AFTN. Read More

    Thyroid cancer in patients with toxic nodular goiter--is the incidence increasing?
    Am J Surg 2015 Jun 25;209(6):974-6. Epub 2015 Mar 25.
    Department of Surgery, MetroHealth Medical Center, Case Western Reserve University, Cleveland, OH, USA. Electronic address:
    Background: There has been a dramatic increase in the incidence of thyroid cancer, but it is unclear if this has occurred in patients with toxic nodular goiter (TNG).

    Methods: TNG was defined as one or more thyroid nodules in combination with a low serum TSH level. Patients who underwent thyroidectomy for TNG were identified from a prospectively maintained database. Read More

    Histopathological findings in goiter: A review of 624 thyroidectomies.
    Neuro Endocrinol Lett 2015 ;36(1):48-52
    Department of Microbiology, Faculty of Medicine, King Abdulaziz University, (Rabigh campus), Jeddah, Saudi Arabia.
    Objectives: To identify the histopathological patterns of goiter in thyroidectomy specimens and their frequency in relation to age and gender of the patients.

    Methodology: We present a retrospective data of 624 thyroidectomy specimens diagnosed over a period of six year (2007-2012) at the Department of Pathology, Holy Family Hospital, Rawalpindi, Pakistan.

    Results: A total of 624 consecutive thyroidectomy specimens were selected. Read More

    Factors affecting hypocalcaemia following total thyroidectomy: a prospective study.
    Eurasian J Med 2014 Feb;46(1):15-21
    Department of General Surgery, Faculty of Medicine, Ataturk University, Erzurum, Turkey.
    Objective: After thyroidectomy hypocalcaemia is the most significant complication for clinicians. In this study, we investigated the factors associated with development of hypocalcaemia after thyroidectomy.

    Materials And Methods: We investigated the patients prospectively for age, gender, preoperative diagnosis, hormonal status, operative time, operating surgeon, existence of parathyroid gland injury at the operation, parathyroid gland auto-transplantation, preoperative use of anti-thyroid drugs and amount of bleeding at the operation. Read More

    Surgical management of hyperthyroidism.
    Eur Ann Otorhinolaryngol Head Neck Dis 2015 Apr 12;132(2):63-6. Epub 2015 Jan 12.
    Service ORL et de Chirurgie Cervico-Faciale, Hôpital Nord, CHU de Saint-Étienne, 42055 Saint-Étienne cedex 2, France.
    Aims: Hyperthyroidism includes several clinical and histopathological situations. Surgery is commonly indicated after failure of medical treatment. The aim of this study was to analyze the indications and complications of surgery as well as endocrine results. Read More

    Iodine deficiency and thyroid disorders.
    Lancet Diabetes Endocrinol 2015 Apr 13;3(4):286-95. Epub 2015 Jan 13.
    Centre for Endocrinology, Diabetes & Metabolism, School of Clinical and Experimental Medicine, University of Birmingham, Birmingham, UK.
    Iodine deficiency early in life impairs cognition and growth, but iodine status is also a key determinant of thyroid disorders in adults. Severe iodine deficiency causes goitre and hypothyroidism because, despite an increase in thyroid activity to maximise iodine uptake and recycling in this setting, iodine concentrations are still too low to enable production of thyroid hormone. In mild-to-moderate iodine deficiency, increased thyroid activity can compensate for low iodine intake and maintain euthyroidism in most individuals, but at a price: chronic thyroid stimulation results in an increase in the prevalence of toxic nodular goitre and hyperthyroidism in populations. Read More

    Peculiarities of non-malignant endocrine disease in the Chornobyl NPP accident survivors, and hormonal interaction role.
    Probl Radiac Med Radiobiol 2014 Sep;19:256-66
    State Institution National Research Center for Radiation Medicine of the National Academy of Medical Sciences of Ukraine, Melnykov str., 53, Kyiv, 04050, Ukraine.
    Study objective. Identification of the role of intersystemic hormonal interactions in development of most prevalent central and peripheral non-malignant clinical/metabolic endocrine disorders in the Chornobyl NPP accident (ChNPPA) survivors. Materials and methods. Read More

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