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Medicina (Kaunas) 2020 Jun 12;56(6). Epub 2020 Jun 12.

Collegium Medicum, Jan Kochanowski University, IX Wieków Kielc Av.19, 25-319 Kielce, Poland.

Agranulocytosis is a rare but very serious complication of thyrostatic therapy. In severe hyperthyroidism, the removal of circulating thyroid hormones by plasmapheresis may be an effective therapeutic option. This report describes the therapeutic difficulties and successful preoperative treatment with plasmapheresis in a 63-year-old patient admitted to the Endocrinology Clinic with severe hyperthyroidism, during the course of giant toxic nodular goiter and agranulocytosis, which occurred after 2 weeks of taking methimazole. Read More

Endokrynol Pol 2020 Apr 15. Epub 2020 Apr 15.

Department of Endocrinology, Holycross Cancer Center, Kielce, Poland.

Background: Graves disease (GD) as a consequence of radioactive iodine (RAI) therapy is rare, usually presenting as post-therapeutic-RAI immunogenic hyperthyroidism. The present study describes a patient with a thyroid remnant after surgery and no metastases of papillary thyroid cancer who was treated with low activity RAI. Her RAI-induced GD manifested clinically as Graves orbitopathy (GO), and she had high levels of antibodies to thyroid stimulating hormone receptor (TRAb). Read More

Ann Ital Chir 2020 ;91:16-22

Objective: Hyperthyroidism is a group of diseases with many different etiologies and clinical manifestations. The most common causes include toxic multi-nodular goiter, Graves' disease and toxic adenoma. The prevalence of thyroid cancer developing in patients with hyperthyroidism has gradually increased in recent years. Read More

Ethiop J Health Sci 2020 Jan;30(1):31-36

Surgery and Renal Transplant Surgeon, St. Paulos Hospital Millennium Medical College.

Background: Thyroid disease is a common disorder of the endocrine system worldwide. It is a common problem in developing countries, including Ethiopia. The aim of this study was to determine the burden and the pattern of thyroid disease in St. Read More

Khirurgiia (Mosk) 2020 (1):89-93

Pirogov National Medical Surgical Center of the Ministry of Health of the Russia, Moscow, Russia.

A well-known feature of primary hyperparathyroidism (PHPT) is possible ectopic localization of parathyroid adenoma that can significantly complicate diagnostic process. Ectopia in the aortic window is extremely rare and accounts only 1% of ectopic parathyroid adenomas in the mediastinum and 0.24% among all parathyroid adenomas. Read More

Thyroid 2020 May 3;30(5):672-680. Epub 2020 Mar 3.

Department of Endocrinology and Metabolism, Odense University Hospital, Odense, Denmark.

Dementia is an increasing burden to the health care system. It is currently debated whether hyperthyroidism is associated with a risk of dementia. Our aim was to determine the risk of dementia in hyperthyroid individuals and whether this was associated with duration of hyperthyroidism. Read More

Nucl Med Commun 2020 Apr;41(4):344-349

Department of Nuclear Medicine, Faculty of Medicine University of Rijeka, Clinical Department of Nuclear Medicine, Clinical Hospital Centre Rijeka, Rijeka, Croatia.

Objectives: Thyroglobulin is routinely used as a tumor marker in follow up of patients with thyroid carcinoma, but is also elevated in patients with toxic nodular goiter. The aim of this study was to evaluate the role of thyroglobulin measurement prior to and after the radioiodine therapy (RIT) in patients with toxic nodular goiter and to compare the results with the therapy outcome.

Patients And Methods: In 109 patients with toxic nodular goiter (102 females, 7 males, aged 45-85 years), 61 with multinodular toxic goiter and 48 with toxic adenoma, thyroglobulin level was measured before RIT and during the first 12 months after the treatment and compared to therapy outcome, defined as euthyroid, hypothyroid and persistent hyperthyroidism. Read More

Biol Trace Elem Res 2020 Aug 5;196(2):393-399. Epub 2019 Nov 5.

Department of Epidemiology of Endocrine Diseases, Institute of Endocrinology and Metabolism of National Academy of Medical Sciences of Ukraine, Vyshgorodska St. 69, Kyiv, Ukraine.

The present study investigated the status of calcium and magnesium as well as essential trace elements including iodine, selenium, copper, iron, and zinc in adults residing in the Zhytomyr region of Ukraine. In addition, the relative risk of goiter occurrence was evaluated. In this comparative study, 40 adults without goiter (control group) and 16 adults with diagnosed nodular goiter (NG) were examined. Read More

Front Endocrinol (Lausanne) 2019 17;10:707. Epub 2019 Oct 17.

Department of Radiology, National Institute of Geriatrics Rheumatology and Rehabilitation, Warsaw, Poland.

Despite unquestionable clinical usefulness of Clinical Activity Score, the evaluating system needs frequent supplementation. One of such diagnostic tools is Doppler imaging that is used for the analysis of flow in the retrobulbar vessels. The improvement of the reliability and sensibility of measurements could make Doppler imaging an everyday clinical tool and improve the efficacy of treatment in patients with active thyroid-associated orbitopathy. Read More

Diagn Cytopathol 2020 Jan 31;48(1):3-9. Epub 2019 Oct 31.

Department of Endocrinology and Metabolism, Ankara Yildirim Beyazit University Faculty of Medicine, Ankara, Turkey.

Background: In this study, we aimed to evaluate ultrasonographical and cytological features of thyroid nodules in patients who were treated with radioactive iodine (RAI) for hyperthyroidism years ago.

Methods: Patients who had a history of RAI treatment for hyperthyroidism and had thyroid nodules that were evaluated with fine-needle aspiration biopsy (FNAB) were included in the study.

Results: There were 27 patients (22 female and 5 male) with a mean age of 59. Read More

J Surg Res 2020 01 23;245:523-528. Epub 2019 Aug 23.

Division of Endocrine Surgery, DeWitt Daughtry Family Department of Surgery, Leonard M. Miller School of Medicine, University of Miami, Miami, Florida.

Background: The rate of thyroid cancer in patients with hyperthyroidism is reported to be rare, and patients with toxic thyroid nodules do not routinely undergo fine-needle aspiration (FNA) to evaluate for malignancy. However, higher rates of malignancy in hyperthyroid patients may exist than previously reported. This study examines the rate of malignancy in patients with hyperthyroidism who have undergone thyroidectomy. Read More

Clin Endocrinol (Oxf) 2019 11 10;91(5):652-659. Epub 2019 Sep 10.

Department of Endocrinology, Aalborg University Hospital, Aalborg, Denmark.

Objective: To investigate the impact of mandatory iodine fortification (IF) on the incidence of nosological subtypes of overt thyrotoxicosis and hypothyroidism.

Design: We identified and scrutinized all possible new cases of overt thyrotoxicosis and hypothyroidism in an open cohort in Northern Jutland (n = 309 434; 1 January 1997) during the years 2014-2016. Individual medical history was evaluated to verify and detail the incidence of overt thyroid dysfunction and for classification into nosological subtypes. Read More

JAMA Intern Med 2019 Jul 1. Epub 2019 Jul 1.

Hirosoft International, Eureka, California.

Importance: Radioactive iodine (RAI) has been used extensively to treat hyperthyroidism since the 1940s. Although widely considered a safe and effective therapy, RAI has been associated with elevated risks of total and site-specific cancer death among patients with hypothyroidism.

Objective: To determine whether greater organ- or tissue-absorbed doses from RAI treatment are associated with overall and site-specific cancer mortality in patients with hyperthyroidism. Read More

Ann Endocrinol (Paris) 2019 Sep 21;80(4):211-215. Epub 2019 Jun 21.

Université de Tunis El Manar, faculté de médecine de Tunis, department of Endocrinology, La Rabta hospital, 1007 Tunis, Tunisia. Electronic address:

Cardiothyreosis (CT) or thyrotoxic heart disease is associated with higher morbidity and mortality than the other forms of hyperthyroidism. Its risk factors have been analyzed in a limited number of studies. The aims of our study were to investigate the prevalence of CT and its risk factors in patients with hyperthyroidism. Read More

Ann Ital Chir 2019 May 8;8. Epub 2019 May 8.

Objective: Hyperthyroidism is a group of diseases with many different etiologies and clinical manifestations. The most common causes include toxic multi-nodular goiter, Graves' disease and toxic adenoma. The prevalence of thyroid cancer developing in patients with hyperthyroidism has gradually increased in recent years. Read More

Acta Endocrinol (Buchar) 2018 Jul-Sep;14(3):324-329

Necmettin Erbakan University, Faculty of Medicine, Endocrinology, Konya, Turkey.

Purpose: Previous studies have demonstrated the relationship between hyperthyroidism and increased risk of cardiac arrhythmias. The most common causes of hyperthyroidism are Graves' disease (GD) and toxic nodular goiter (TNG). The aim of our study was to demonstrate if the underlying mechanism of hyperthyroidism, in other words autoimmunity, has an impact on the type of cardiac arrhythmias accompanying hyperthyroidism. Read More

Surgery 2019 09 16;166(3):356-361. Epub 2019 May 16.

Department of Endocrinology and Metabolism, Ankara Yıldırım Beyazıt University Faculty of Medicine, Ankara, Turkey.

Background: The suppressive effect of the increase in thyroid hormone in patients with toxic nodular goiter is thought to protect the extranodular thyroid tissue from thyroid malignancy. In this study, we aimed to evaluate the prevalence and features of thyroid cancer in patients with toxic nodular goiter who underwent thyroidectomy.

Methods: Medical data of patients who had solitary toxic or nontoxic nodules and underwent total thyroidectomy were reviewed retrospectively. Read More

Niger J Surg 2019 Jan-Jun;25(1):64-69

Department of Surgery, Obafemi Awolowo University Teaching Hospitals Complex, Ile Ife, Osun State, Nigeria.

Background: The principles of safe and efficient thyroid surgery had been established and the technique has remained the same for over the century without any major significant changes. The introductions of electrosurgical devices constitute a major shift in the technique of thyroid surgery.

Objective: We present our early experience with the use of LIGASURE vessel sealing system for the procedure of thyroidectomy. Read More

Nuklearmedizin 2019 Jun 11;58(3):265-271. Epub 2019 Apr 11.

Department of Nuclear Medicine, University Hospital of Cologne.

Aim: Thyroid hemiagenesis (TH) is a rare congenital anomaly in which one thyroid lobe fails to develop. We describe our experience with at least 13 patients presenting with TH at our department.

Methods: We retrospectively analysed patients with TH, who had been referred primarily to our clinic between 2004 and 2010. Read More

Pan Afr Med J 2018 20;31:43. Epub 2018 Sep 20.

Service d'Oto-Rhino-Laryngologie, Hôpital Militaire Avicenne, Marrakech, Maroc.

Hyperthyroidism includes several diseases characterized by high level of circulating thyroid hormones. Thyroidectomy is one of the main treatment options. We conducted a retrospective study to evaluate the epidemiological, clinical, therapeutic, evolutionary features of patients who had undergone surgery for hyperthyroidism in the ENT Department at the Avicenne Military Hospital in Marrakech. Read More

Thyroid 2019 04 22;29(4):595-606. Epub 2019 Mar 22.

1 School of Medicine, Department of Normal and Pathological Cytology and Histology, University of Seville, Seville, Spain.

Background: Primary cilia (PC) are conserved structures in the adult thyroid gland of different mammals. It was recently described that in humans, PC are usually present as a single copy per follicular cell emerging from the follicular cell apex into the follicular lumen.

Methods: To understand the role developed by PC in thyroid hormonogenesis better, their changes in different human functional thyroid diseases (diffuse toxic hyperplasia/Graves' disease [GD] and nodular hyperplasia [NH]/nodular goiter), in comparison to normal thyroid tissue, were investigated using immunofluorescence, morphometry, and electron microscopy analyses. Read More

Ethiop J Health Sci 2019 Jan;29(1):887-894

Department of Internal Medicine, Cardiology Unit, St. Paul's Hospital Millennium Medical College, Addis Ababa, Ethiopia.

Background: Thyro-cardiac disease describes the existence of a combination of thyroid toxicity and significant heart disease in an individual patient. The frequent manifestations of thyro-cardiac disease are hypertension, atrial flutter or fibrillation, pulmonary hypertension and dilated cardiomyopathy. The aim of the study was to determine the pattern and presentation of cardiovascular diseases in patients with hyperthyroidism on follow-up at St. Read More

Eur J Obstet Gynecol Reprod Biol 2019 Mar 9;234:43-48. Epub 2019 Jan 9.

Department of Internal Medicine and Clinical Pharmacology, Medical University of Silesia, Katowice, Poland.

Objective: Despite high prevalence in a female population, surprisingly little is known about sexual functioning of women with thyroid hyperfunction. This study was aimed at assessing female sexual function and depressive symptoms in women with overt hyperthyroidism of autoimmune and non-autoimmune origin.

Study Design: The study included three age-matched groups of young women inhabiting the Upper Silesia (a selenium-deficient and iodine-sufficient area): individuals with overt hyperthyroidism induced by Graves' disease (group A, n = 31), women with overt hyperthyroidism caused by toxic multinodular goiter or toxic adenoma (group B, n = 30) and women with normal thyroid function (group C, n = 34). Read More

Ann Endocrinol (Paris) 2019 Apr 25;80(2):101-109. Epub 2018 Sep 25.

Service de chirurgie viscérale et endocrinienne, CHU d'Angers, 4, rue Larrey, 49100 Angers, France.

Objectives: Multinodular goiter is a common disorder, found in 5% of the general population. If only one thyroid lobe is affected, hemithyroidectomy may be preferred to total thyroidectomy, to limit the risk of complications and avoid hormone replacement therapy, but incurs a risk of subsequent completion thyroidectomy. The aim of the present study is to determine whether the arguments in favor of hemithyroidectomy are justified and whether it still provides real benefit. Read More

Front Endocrinol (Lausanne) 2018 3;9:737. Epub 2018 Dec 3.

Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, Philadelphia, PA, United States.

This article reviews those pathologic lesions which are associated with clinical and/or biochemical hyperthyroidism. Beginning with the descriptive pathology of classical Graves' disease and the less common toxic nodular goiter and hyper-functioning thyroid nodules, this paper describes the effects of non-thyroidal hormones, glandular function (including pituitary and hypothalamic lesions), ectopic production of thyroid stimulating proteins by non-thyroidal neoplasms, exogenous drug reactions causing hyper-function and finally conditions associated with a mechanic- destructive cause of hyperthyroidism. Read More

World J Surg 2019 Apr;43(4):1022-1028

Department of General Surgery, Monash University Endocrine Surgery Unit, The Alfred Hospital, 55 Commercial Rd, Melbourne, VIC, 3004, Australia.

Background: Since the mid-1800s, thyroidectomy has transformed from a procedure associated with high to near-zero mortality. Nonetheless, surgeons must continue to strive to improve patient care. Using historical records and contemporary data, this study compares the practice and outcomes of thyroid surgery at a tertiary institution during two periods, 50 years apart. Read More

Clin Epidemiol 2018 10;10:1447-1455. Epub 2018 Oct 10.

Division or Rheumatology, Orthopaedics and Dermatology, School of Medicine, University of Nottingham, Nottingham, UK,

Purpose: To estimate the extent of familial aggregation of type 1 diabetes (T1D) and coaggregation of related chronic diseases and assess the relative contribution of environmental and genetic factors on the risks.

Patients And Methods: This population-based study used the Taiwan National Health Insurance database to reconstruct family structure and identify people with T1D and other chronic diseases between 1999 and 2015. Relative risks (RRs) for T1D and other chronic diseases and heritability of T1D were estimated. Read More

Pak J Med Sci 2018 Sep-Oct;34(5):1146-1151

Muhammad Areeb Ashfaq, Medical Student, Aga Khan University Hospital, Karachi, Pakistan.

Objective: To determine the outcome of patients receiving radioactive iodine therapy for toxic nodular goiter coming to Aga Khan University Hospital Karachi.

Methods: A total of 89 patients who visited the outpatient department of Aga Khan University Hospital from January 2010 to August 2017 were recruited for the study. Toxic nodular goiter was diagnosed on the basis of having hot nodule on thyroid scan with low TSH and high FT4/T4. Read More

Endokrynol Pol 2019 11;70(1):64-71. Epub 2018 Oct 11.

Department of Internal Medicine and Clinical Pharmacology, Medical University of Silesia, Katowice, Poland.

Introduction: Although hyperthyroidism is characterised by female predominance, its presence may lead to the development of numerous complications in both sexes. This study was aimed at investigating sexual function and depressive symptoms in men with overt hyperthyroidism of autoimmune and non-autoimmune origin.

Material And Methods: The study population consisted of three age-matched groups: men with overt hyperthyroidism and Graves' disease (group A; n = 20), men with overt hyperthyroidism and toxic multinodular goitre or toxic adenoma (group B; n = 21), and men with normal thyroid function (group C; n = 23). Read More

BMJ Case Rep 2018 Sep 25;2018. Epub 2018 Sep 25.

Nuclear Medicine Division, Radiotherapy, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, Karnataka, India.

Neck haematoma following thyroid surgery can present with respiratory distress which is generally attributed to airway obstruction. We recently had a 63-year-old female patient who underwent total thyroidectomy for toxic nodular goitre. However, within 4 hours of surgery, she developed sudden respiratory distress which was managed by prompt evacuation of the neck haematoma. Read More

Horm Metab Res 2018 Sep 5;50(9):653-660. Epub 2018 Sep 5.

Department of Endocrinology, Metabolism and Internal Medicine, Poznan University of Medical Sciences, Poznań, Poland.

We aimed to analyze the potential influence of thyroid autoimmunity on visfatin/NAMPT serum concentration and its leukocyte expression in hyperthyroid patients. This is a single-center, cross-sectional study with consecutive enrollment. All patients with newly diagnosed overt hyperthyroidism in a course of Graves' disease or toxic nodular goiter were included in the study. Read More

Endocr Connect 2018 Aug 23. Epub 2018 Aug 23.

F Brandt, Department of Internal Medicine, Hospital of Southern Jutland, Sønderborg, Denmark

Background: Season of birth, an exogenous indicator of early life environment, has been linked with a higher risk of adverse health outcomes such as autoimmune thyroiditis, multiple sclerosis and schizophrenia later in life. Whether the development and cause of hyperthyroidism is influenced by season of birth is unclarified. We aimed, at a nationwide level, to investigate whether season of birth influences the risk of hyperthyroidism due to Graves' disease (GD) and/or toxic nodular goitre (TNG). Read More

J Clin Endocrinol Metab 2018 10;103(10):3668-3677

Molecular Thyroid Research Laboratory, Department of Medicine I, Johannes Gutenberg University Medical Center, Mainz Germany.

Context: We hypothesized that TSH-receptor (TSHR) stimulating antibodies (TSAbs) are involved in oxidative stress mechanisms in patients with Graves disease (GD).

Methods: Nicotinamide adenine dinucleotide phosphate oxidase, isoform 2 (NOX2); oxidative parameters; and oxidative burst were measured in serum, urine, and whole blood from patients with GD and control subjects. Superoxide production was investigated in human embryonic kidney (HEK)-293 cells stably overexpressing the TSHR. Read More

Endocr Pract 2018 Jul;24(7):628-633

Objective: Primary hyperparathyroidism (PHPT) and thyroid diseases are highly prevalent in the general population, but the putative link between the 2 conditions remains unclear.

Methods: A monocentric consecutive series of 434 patients with PHPT was retrospectively evaluated by lab and ultrasonography to look for thyroid abnormalities. Patients were classified in 3 groups: without thyroid abnormalities (group 1, n = 171), with thyroid diseases not previously known (group 2a, n = 69), and thyroid diseases previously known (group 2b, n = 194). Read More

Thyroid 2018 10 21;28(10):1261-1269. Epub 2018 Aug 21.

2 Department of Medical Endocrinology, Copenhagen University Hospital Rigshospitalet , Copenhagen, Denmark .

Background: This study aimed to characterize the frequency of self-reported thyroid-related impaired sex life in patients with thyroid diseases, to examine its clinical correlates and relationship with overall quality of life (QOL), and to investigate the effect of treatment.

Patients And Methods: Two separate patient samples with benign thyroid diseases were investigated: a cross-sectional sample (759 women and 118 men) treated at two Danish university hospital outpatient clinics, in 2007-2008, and a longitudinal sample (358 women and 74 men) undergoing treatment at the abovementioned centers, during 2008-2012, evaluated before and 6 months after therapy. The thyroid-specific QOL questionnaire ThyPRO was used to measure patient-evaluated thyroid-related sex life impairment. Read More

Med J Aust 2018 07;209(2):92-98

Austin Health, Melbourne, VIC.

Thyroid nodules are common. Their importance lies in the need to assess thyroid function, degree of and future risk of mass effect, and exclude thyroid cancer, which occurs in 7-15% of thyroid nodules. There are four key components to thyroid nodule assessment: clinical history and examination, serum thyroid stimulating hormone (TSH) measurement, ultrasound and, if indicated, fine-needle aspiration (FNA). Read More

Endocrine 2018 10 2;62(1):144-148. Epub 2018 Jul 2.

Ege University Medical Faculty, Division of Endocrinology and Metabolism Disorders, Izmir, Turkey.

Purpose: For the treatment of thyrotoxicosis, alternative treatment modalities may be necessary if anti-thyroid drugs cannot be used due to side effects, inefficiencies, or there is a need to start a rapid action such as thyroid storm. By using therapeutic plasma exchange (TPE), it is possible to effectively and rapidly remove the increased thyroid hormones. We evaluated our results and experience on a rapid, effective, and reliable alternative treatment modality in thyrotoxic patients. Read More

Porto Biomed J 2018 Nov-Dec;3(3):e19. Epub 2018 Jul 3.

Internal Medicine Department, Hospital São Sebastião, Centro Hospitalar Entre Douro e Vouga, Santa Maria da Feira, Portugal.

Hiccups differential diagnosis is a challenging one often being inconclusive and sometimes attributed to malignancies, and so of extreme importance to an internist. Seventy-five-year-old man with history of alcohol abuse, hypertension, and hyperlipidemia presented to the emergency department after having initiated diarrhea, hiccups, and vomiting for 4 days. Physical examination revealed signs of dehydration and persistent hiccups at rest. Read More

Cancer Manag Res 2018 21;10:1201-1207. Epub 2018 May 21.

Department of Endocrinology and Metabolism, West China Hospital, Sichuan University, Wuhou District, Chengdu, Sichuan, People's Republic of China.

Background: The association between Graves' disease (GD) and thyroid carcinoma remains controversial. This study aimed to investigate incidental thyroid carcinoma (ITC) in surgery-treated hyperthyroid patients with and without GD.

Materials And Methods: We searched PubMed and EMBASE for cohort studies investigating ITC in surgery-treated hyperthyroid patients without prediagnosed thyroid carcinoma in accordance with the Meta-Analysis of Observational Studies in Epidemiology guidelines. Read More

Endocr Pract 2018 Jun 24;24(6):573-579. Epub 2018 Apr 24.

Objective: Few studies on hyperthyroidism treatment have been reported in the past 3 decades. We used a nationwide population-based database to evaluate the current practices and management of hyperthyroidism in Taiwan.

Methods: This retrospective study included a random selection of 1 million people in Taiwan between 2004 and 2010. Read More

Biomed Res Int 2018 6;2018:1316390. Epub 2018 Feb 6.

Department of Endocrinology, Metabolism and Internal Medicine, Poznan University of Medical Sciences, Przybyszewskiego St. 49, 60-355 Poznań, Poland.

Purpose: Our aim was to analyze NAMPT expression in thyroid tissue derived from patients with Graves' disease with (GD) and without (GO) orbitopathy, patients with toxic nodular goiters (TNG) and thyroid cancers (TC), and healthy controls.

Methods: 153 thyroid tissue samples of consecutive patients who underwent thyroidectomy were collected. Previous therapy with steroids was an exclusion criterion. Read More

Endokrynol Pol 2018 5;69(3):235-240. Epub 2018 Mar 5.

Department of Endocrinology, Metabolism and Internal Medicine, Poznan University of Medical Sciences; Department of Pharmacology, University of Medical Sciences, Poznan.

Introduction: Cardiovascular diseases constitute a major cause of health problems and death in developed countries across the world. The increased value of the index of distribution of red blood cells volume (RDW) may be a prognostic marker in patients diagnosed with chronic heart failure (CHF). Hypothyroid patients present higher RDW values if compared to healthy controls. Read More

Int J Hyperthermia 2018 08 22;34(5):631-635. Epub 2018 Feb 22.

b Studio Tiroide Prof. De Feo , Perugia , Italy.

Purpose: To confirm the effectiveness of laser ablation on toxic nodules in a large population with three years of follow-up.

Material And Methods: Between 2009 and 2014, we treated 82 patients with hyperthyroidism related to the presence of a toxic nodular goitre. Patients were pre-treated pharmacologically with methimazole prior to single session of laser ablation (LA) and then followed up every 3 months with FT4 and TSH blood tests as well as ultrasound examination of the nodules treated. Read More

J Endocrinol Invest 2018 Sep 20;41(9):1019-1028. Epub 2018 Jan 20.

Endocrinology, Diabetes and Metabolism Unit, Department of Internal Medicine, Hospital of Egas Moniz, Lisbon's Occidental Center of Hospitals, Estrada do Forte do Alto do Duque, 1449-005, Lisbon, Portugal.

Background: Graves' disease (GD) arising after the treatment of toxic multinodular goitre (TMNG) with radioiodine has long been described but it remained unclear whether GD was in fact iodine induced, its incidence, risk factors, natural history and treatment outcomes.

Methods: A systematic search using The Cochrane Library, Medline and PubMed Central allowed the pooling of data from 3633 patients with thyroid autonomy, 1340 patients with TMNG, to fill gaps in knowledge, regarding the clinical expression of iodine-induced GD (I-IGD) in adults.

Results: I-IGD developed in 0-5. Read More

N Z Med J 2018 01 19;131(1468):69-74. Epub 2018 Jan 19.

Endocrinologist, Waikato Clinical Campus, University of Auckland, Hamilton.

Background: Previously the risk of concomitant thyroid cancer in multinodular goitre (MNG) has been reported as approximately 4%. Cancer risk in toxic MNG was often considered lower than for non-toxic MNG, due to a possible protective effect of TSH suppression. However, recent American data suggest an approximately 18% risk of occult malignancy in both toxic and non-toxic MNG. Read More

Endocrine 2018 01 2;59(1):137-142. Epub 2017 Dec 2.

Department of Endocrinology and Metabolism, Odense University Hospital, Kløvervænget 6, 5000, Odense, Denmark.

Purpose: Graves' disease (GD) and toxic nodular goiter (TNG) are associated with various comorbidities. However, it is unclarified whether TNG and GD without orbitopathy are associated with glaucoma.

Methods: This was a case-control study using record-linkage data from nationwide Danish health registers. Read More

Cureus 2017 Sep 17;9(9):e1695. Epub 2017 Sep 17.

Department of Surgery, Duzce University Medical Faculty.

Thyroid hemiagenesis (TH) is a rare congenital anomaly that is usually asymptomatic. Functional disorders of the thyroid make the patient symptomatic. TH is usually and incidentally established during evaluation of patients with symptomatic thyroid pathology. Read More

Turk J Med Sci 2017 11 13;47(5):1509-1519. Epub 2017 Nov 13.

Background/aim: To evaluate the malignancy risk of thyroid nodules in different clinical thyroid diseases. Materials and methods: Patients who underwent thyroidectomy between 2007 and 2014 were grouped as euthyroid, hypothyroid, and hyperthyroid. Further classification was made depending on the presence of solitary/multiple thyroid nodules. Read More

Med Arch 2017 Aug;71(4):270-273

Clinic of Nuclear Medicine and Endocrinology, University Clinical Center Sarajevo, Sarajevo, Bosnia and Herzegovina.

Introduction: Consensus hasn't been yet achieved about optimal dose quantity that could prevent post therapy hypothyroidism, thus dosing approach varies among different centers. I131 doses can be fixed or calculated, although treatment outcomes don't differ significantly according to recent acknowledgments.

Aim: Determination of the incidence of hypothyroidism after radioiodine treatment (I131) in dependence of hyperthyroidism etiology and quantity of applied doses. Read More