Search Our Scientific Publications & Authors

Int J Surg Oncol 2022 23;2022:1054297. Epub 2022 May 23.

General Surgery, Faculty of Medicine, Al-Azhar University, Cairo, Egypt.

Background: Although hyperfunctioning thyroid disorders were thought to be protective against malignancy, some recent studies reported a high incidence of incidentally discovered cancer in patients with hyperfunctioning benign thyroid disorders. We performed this study to estimate the incidence and predictors of malignant thyroid disease in patients with toxic nodular goiter (TNG). . Read More

Sci Rep 2022 May 28;12(1):8987. Epub 2022 May 28.

School of Veterinary Medicine and Science, University of Nottingham, Sutton Bonington Campus, Nottingham, LE12 5RD, UK.

Hyperthyroidism is a common endocrinopathy of domestic felines. In humans, toxic nodular goitre is pathophysiologically similar to feline hyperthyroidism and can be caused by chronically low or fluctuating dietary iodine intake. The aetiopathogenesis of feline hyperthyroidism is not known, but chronically low or fluctuating dietary iodine intake is likely common. Read More

J Nucl Med Technol 2022 May 24. Epub 2022 May 24.

Temple University Hospital, United States.

Hyperthyroidism is often managed with radioactive iodine therapy. The dose of Iadministered to the patient is determined based on the calculated size of the thyroid gland in gram and 24 hour iodine uptake. Ultrasonography is a validated modality for determination of thyroid volume. Read More

Clin Endocrinol (Oxf) 2022 Jul 11;97(1):124-129. Epub 2022 May 11.

Department of Nuclear Medicine, Royal Melbourne Hospital, Parkville, Victoria, Australia.

Background: The modern era of radioiodine (I-131) theranostics for metastatic differentiated thyroid cancer requires us to rationalize the role of traditional empiric prescription in nonmalignant thyroid disease. We currently practice empiric I-131 prescription for treatment of hyperthyroidism. This study aims to assess outcomes after treatment of hyperthyroidism by empiric I-131 prescription at our centre, evaluate factors that impact on outcomes and prescribing practice, and gain insight into whether there is a place for theranostically-guided prescription in hyperthyroidism. Read More

Thyroid Res 2022 Apr 25;15(1). Epub 2022 Apr 25.

Department of Medical Radiation Physics and Nuclear Medicine, Karolinska University Hospital, Stockholm, Sweden.

Background: Hyperthyroidism has been treated with radioiodine therapy for eight decades, with known benefits and side-effects. No consensus exists on which activity dosage and pre-therapeutic measurements are required for optimal treatment, balancing risk of incomplete response, therapy-induced hypothyroidism and radiation exposure. A retrospective analysis was performed to assess these questions. Read More

Acta Endocrinol (Buchar) 2021 Jul-Sep;17(3):393-398

"Sf. Spiridon" County Emergency Hospital - Nuclear Medicine Laboratory.

A 62 years old woman was diagnosed with multinodular toxic goiter and primary hyperparathyroidism/left parathyroid adenoma by hormonal assessment, ultrasound and nuclear thyroid/parathyroid scans. Cervical ultrasound illustrated a multinodular aspect of the thyroid with solid nodules and cystic-component nodules; the larger one represented a multinodular complex with necrosis areas in the left thyroid lobe, ACR TI-RADS score 4 (moderately suspicious). Functional nuclear imaging was performed for accurate differential diagnosis between thyroid . Read More

World J Surg 2022 05 21;46(5):1105-1106. Epub 2022 Feb 21.

Karolinska University Hospital, Stockholm, Sweden.

Ther Clin Risk Manag 2021 15;17:1091-1101. Epub 2021 Oct 15.

Department of Public Health, College of Medicine and Health Sciences, Adigrat University, Adigrat, Ethiopia.

Purpose: To determine the time to euthyroidism and its determinants among thyrotoxicosis patients on anti-thyroid drug attending the medical and ambulatory clinics of South Tigrai General Hospitals, Ethiopia, 2015-2020.

Methods: A multi-center retrospective cohort study was conducted from March 30, 2020, to July 30, 2020, among adult thyrotoxicosis patients who received anti-thyroid medications in the medical and chronic ambulatory clinics of South Tigrai General Hospitals, Ethiopia. Epi-data manager version 3. Read More

Endocr Connect 2021 Oct 25;10(11):R279-R292. Epub 2021 Oct 25.

Department of Pediatric Endocrinology and Rheumatology, Institute of Pediatrics, Karol Jonscher's Clinical Hospital, Poznan University of Medical Sciences, Poznan, Poland.

The term 'hyperthyroidism' refers to a form of thyrotoxicosis due to inappropriate high synthesis and secretion of thyroid hormone(s) by the thyroid. The leading cause of hyperthyroidism in adolescents is Graves' disease (GD); however, one should also consider other potential causes, such as toxic nodular goitre (single or multinodular), and other rare disorders leading to excessive production and release of thyroid hormones. The term 'thyrotoxicosis' refers to a clinical state resulting from inappropriate high thyroid hormone action in tissues, generally due to inappropriate high tissue thyroid hormone levels. Read More

Sci Rep 2021 09 21;11(1):18706. Epub 2021 Sep 21.

Department of Endocrinology, Metabolism and Internal Medicine, Poznan University of Medical Sciences, 49 Przybyszewskiego St., 60-355, Poznan, Poland.

Thyroid diseases may cause a variety of functional and structural body changes, including eye and vision abnormalities, which can have a negative impact on a patient's well-being. However, only a few studies on the impact of other benign thyroid diseases on the visual process are available in the literature. In this study, using the Polish version of the thyroid-specific quality of life (ThyPROpl) questionnaire, we aimed to determine the self-reported influence of benign thyroid diseases (e. Read More

Ir J Med Sci 2021 Sep 18. Epub 2021 Sep 18.

Department of Endocrinology, Royal Berkshire NHS Foundation Trust Hospital, Reading, Berkshire, UK.

Background: Iodine-131 is an effective treatment for thyrotoxicosis. In 2019, National Institute for Clinical Excellence guidelines (UK) suggested offering radioactive iodine as first-line definitive treatment for adults with Graves' disease, toxic nodular and multinodular goitre unless it is unsuitable or anti-thyroid drugs are likely to achieve remission. The aim of this study was to evaluate the clinical outcome 1 year after using fixed-dose Iodine-131 for hyperthyroidism and time (months) to response. Read More

Ann R Coll Surg Engl 2021 Oct 27;103(9):683-689. Epub 2021 Aug 27.

Oncology Center Mansoura University, Mansoura, Egypt.

Introduction: Thyroid cancer is increasing in incidence globally due either to early detection (overestimation) or true increment. A recent debate concerns multinodular goitre (MNG) or toxic goitres which have classically been considered at a lower risk for cancer.

Methods: In this study, we enrolled retrospectively all patients with nodular goitre treated at our tertiary hospital and analysed their data with the aim of detecting the rate of cancer among different types of nodular goitre. Read More

J Endocrinol Invest 2022 Feb 17;45(2):399-411. Epub 2021 Aug 17.

Endocrinology Unit 1, University Hospital of Pisa, Via Paradisa 2, 56124, Pisa, Italy.

Purpose: Toxic multinodular goiter is a heterogeneous disease associated with hyperthyroidism frequently detected in areas with deficient iodine intake, and functioning and non-functioning nodules, characterized by increased proliferation but opposite functional activity, may coexist in the same gland. To understand the distinct molecular pathology of each entity present in the same gland, the gene expression profile was evaluated by using the Affymetrix technology.

Methods: Total RNA was extracted from nodular and healthy tissues of two patients and double-strand cDNA was synthesized. Read More

BMC Endocr Disord 2021 Jun 28;21(1):132. Epub 2021 Jun 28.

College of Health Sciences, Mekelle University, Mekelle, Ethiopia.

Background: Thyrotoxicosis is the state of thyroid hormone excess. But, in sub-Saharan Africa (SSA), specifically Northern Ethiopia, scientific evidence about thyrotoxicosis and its cardiac complications like dilated cardiomyopathy is limited. Therefore, this study aimed to explore the thyrotoxicosis presentation and management and identify factors associated with dilated cardiomyopathy in a tertiary hospital in Northern Ethiopia. Read More

Endocr Res 2021 Nov 24;46(4):160-169. Epub 2021 May 24.

Department of Surgery, University Hospitals Sussex NHS Foundation Trust (Royal Sussex County Hospital), Brighton, UK.

: The objective of this article is to evaluate the outcomes in patients undergoing radioactive iodine (RAI) with adjunctive lithium (Li) therapy versus (vs.) RAI therapy alone for the treatment of hyperthyroidism.: A systematic review of the literature was undertaken to analyze clinical trials comparing RAI with adjunctive Li therapy vs. Read More

Probl Endokrinol (Mosk) 2021 04 8;67(2):102-110. Epub 2021 Apr 8.

Endocrinology Research Centre.

Background: Toxic nodular goiter (TNG) is a rare disease in which the cause of hyperthyroidism is the presence of a node or nodes that autonomously secrete thyroid hormones. With children and adolescents this condition is extremely rare - in 5-7.5% of all cases of nodular goiter. Read More

J Clin Endocrinol Metab 2021 06;106(7):e2512-e2520

Department of Endocrinology, Odense University Hospital, Denmark.

Background: Whole-body oxidative stress can be estimated by the urine excretion of oxidized guanosine species, 8-oxo-7,8-dihydroguanosine (8-oxoGuo) and 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG), derived from RNA and DNA, respectively. These oxidative stress markers are not well explored in thyroid disorders.

Objective: We aimed to determine whether treatment of hyperthyroid patients affects the levels of these oxidative stress markers. Read More

Cell Biochem Funct 2021 Jul 16;39(5):658-666. Epub 2021 Mar 16.

Department of Endocrinology and Metabolism, Kocaeli University Faculty of Medicine, Kocaeli, Turkey.

Graves' disease (GD) and toxic multinodular goitre (TMNG) are the most common thyroid diseases which mainly lead to thyrotoxicosis, however, the underlying mechanism of distinct clinical presentations remains unclear. Protein extracts from the thyroid tissue specimens of the patients with GD and TMNG were subjected to Difference Gel Electrophoresis (DIGE). Differentially regulated protein spots were determined by image analysis, and the spots displaying statistically significant differences were identified by Matrix-Assisted Laser Desorption Ionization Time of Flight Mass Spectrometer (MALDI-TOF) followed by MASCOT search. Read More

Q J Nucl Med Mol Imaging 2021 Jun 10;65(2):138-156. Epub 2021 Feb 10.

Department of Nuclear Medicine, Cochin Hospital, DMU Imagina, Paris University, Paris, France -

Radioiodine therapy (RIT) of thyroid functional autonomy (TFA) is rapidly evolving, though it has been recognized for decades as a very effective treatment of toxic nodular varieties. Indeed, TFA is a frequent cause of persistent subclinical hyperthyroidism, which should be regarded as a new metabolic syndrome, with well-established adverse cardio-vascular consequences. Sensitive TSH assays and multiparametric ultrasounds are not accurate enough to reliably diagnose TFA and identify its main variants, unifocal, multifocal (UFA/MFA) and disseminated autonomy (DISA). Read More

Probl Endokrinol (Mosk) 2020 09 16;66(3):27-32. Epub 2020 Sep 16.

Endocrinology Research Centre.

This research describes a clinical case of treatment of a patient with thyrotoxicosis with concomitant hematological pathology – carriage of unstable hemoglobin Hasharon. A patient diagnosed with «Diffuse toxic nodular goiter. Thyrotoxicosis of medium severity. Read More

Probl Endokrinol (Mosk) 2020 08 4;66(1):87-92. Epub 2020 Aug 4.

Irkutsk Scientific Centre of Surgery and Traumatology; Irkutsk State Medical University.

Background: At the time of seeking medical help, some patients have nodular/multinodular goiter of large and gigantic sizes, which leads to compression of the neck organs. In the structure of benign diseases, neck compression is diagnosed in 10% of cases, and tracheal narrowing is found in 84% of patients in this group. It was experimentally established that narrowing of the trachea leads to the development of hypertension in the pulmonary circulation. Read More

Int J Clin Exp Pathol 2020 1;13(11):2895-2906. Epub 2020 Nov 1.

Department of Thyroid Surgery, The First Hospital Affiliated to Zhejiang University, School of Medicine No. 79 Qingchun Road, Hangzhou 310000, P. R. China.

Introduction: Autonomously functioning thyroid nodules (AFTNs) are generally benign, whereas papillary thyroid carcinomas (PTCs) are mostly non-functioning. Graves' disease (GD) is the most common cause of hyperthyroidism (HD), followed by hyperfunctional adenoma or Plummer's disease. GD with AFTNs is called Marine-Lenhart syndrome, a relatively rare syndrome. Read More

Auris Nasus Larynx 2021 Jun 17;48(3):487-495. Epub 2020 Oct 17.

Department of Nuclear Medicine, The First People's Hospital of Jingzhou City, The First Affiliated Hospital of Yangtze University, Jingzhou 434000, Hubei Province, China. Electronic address:

Objective: To investigate the sineoculis homeobox homolog 1 (SIX1) affect the epithelial mesenchymal transition (EMT) in papillary thyroid carcinoma (PTC) through regulating TGF-β/Smad2/3 signaling pathway.

Methods: The SIX1 expression in cytological specimens, tissues or PTC cell lines was detected by qRT-PCR, western blotting or immunohistochemistry. A series of vitro experiments including flow cytometry, CCK-8, wound-healing and Transwell were used to evaluate the biological characteristics in a PTC cell line (NPA cells), which were divided into Blank, Negative control (NC), SIX1, SIX1-siRNA, LY-364947 (TGF-β/Smad2/3 pathway inhibitor) and SIX1 + LY-364947 groups. Read More

Endocrine 2021 06 3;72(3):735-743. Epub 2020 Oct 3.

Inozemtsev City Clinical Hospital of Moscow Department of Health, Moscow, Russia.

Objective: Cytochrome b5-reductase (CYB5R) and cytochrome P450 reductase (CYPOR) are important for cell metabolism; however, their role in thyroid hormonogenesis and carcinogenesis has not been elucidated yet. The activity of CYB5R correlates with the metastasis in breast cancer, but there are no similar studies for CYB5R and CYPOR for thyroid tumors. The aim of this study was to elucidate the activity of CYB5R and CYPOR changes in benign euthyroid and hyperthyroid neoplasms and in papillary thyroid cancer for their potential application as biomarkers for diagnosis and prognosis prediction of thyroid cancer. Read More

Minerva Endocrinol (Torino) 2021 12 24;46(4):406-412. Epub 2020 Sep 24.

Department of General Surgery, Kartal Dr. Lutfi Kirdar Training and Research Hospital, Istanbul, Turkey.

Background: Multinodular goiter is a common disease. If only one thyroid lobe is affected, hemithyroidectomy may be preferred to reduce complication and hormone replacement therapy. However, completion thyroidectomy may be required later. Read More

Autoimmunity 2020 11 8;53(7):376-384. Epub 2020 Sep 8.

Department of Medical Patomorphology, Medical University of Bialystok, Bialystok, Poland.

Introduction: Recent studies have revealed the presence of zinc and the expression of zinc transporter (ZnT) family members in most endocrine cell types. It was demonstrated that ZnT family plays an important role in the synthesis and secretion of many hormones. Moreover, recently ZnT8 was described as a newly islet autoantigen in type 1 diabetes. Read More

BMC Med 2020 08 25;18(1):225. Epub 2020 Aug 25.

Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, SE-17177, Stockholm, Sweden.

Background: Despite the biological link between thyroid hormones and breast cancer cell proliferation shown in experimental studies, little is known about the association between hyperthyroidism and breast cancer, as well as its association with the most common mammographic and genetic risk predictors for breast cancer.

Methods: This study estimates the incidence rate ratios (IRRs) of breast cancer among women diagnosed with hyperthyroidism, compared to those who are not, using two cohorts: a Swedish national cohort of the general female population (n = 3,793,492, 2002-2011) and the Karolinska Mammography Project for Risk Prediction of Breast Cancer (KARMA, n = 69,598, 2002-2017). We used logistic regression to estimate the odds ratios (ORs) of hyperthyroidism according to the mammographic and genetic risk predictors for breast cancer. Read More

J Clin Endocrinol Metab 2020 11;105(11)

Endocrinology Division, Department of Internal Medicine, University Hospital "Dr. Jose E. Gonzalez," Universidad Autonoma de Nuevo León, Monterrey, Mexico.

J Clin Endocrinol Metab 2020 11;105(11)

Section of Endocrinology, Department of Medical, Surgical and Neurological Sciences, University of Siena, Siena, Italy.