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J Pediatr Endocrinol Metab 2021 Jun 15. Epub 2021 Jun 15.

Division of Pediatric Endocrinology, Faculty of Medicine, İstanbul University - Cerrahpaşa, İstanbul, Turkey.

Objectives: Hashimoto's thyroiditis (HT) is the most common cause of goiter and acquired hypothyroidism in children and adolescents, especially in areas without endemic iodine deficiency. We aimed to evaluate the follow-up results of children and adolescents diagnosed with HT, including clinical, biochemical, and radiological findings and treatment approaches.

Methods: HT patients, who were diagnosed between 2012 and 2018 years in a single-center, were assessed retrospectively. Read More

Case Rep Endocrinol 2021 22;2021:6669653. Epub 2021 May 22.

Pathology Department, School of Medicine, Kerman University of Medical Sciences, Kerman, Iran.

Graves' disease is the most common cause of hyperthyroidism, which is characterized by thyroid antibodies and the following clinical manifestations: goiter, ophthalmopathy, and pretibial myxedema. On the other hand, Henoch-Schönlein purpura is an IgA-mediated small-vessel vasculitis. Review of the literature showed a relationship between propylthiouracil overdose and the following Henoch-Schönlein purpura (IgA vasculitis) as a side effect. Read More

Niger J Clin Pract 2021 Jun;24(6):905-910

Pinnamaneni Siddartha Institute of Medical Sciences (PSIMS), Gannavaram, Vijayawada, AP, India.

Background: Hashimoto's thyroiditis (HT) is one of the commonest endocrine disorders, globally. Often, HT presents a protean range of associated autoimmune features (AAI) such as vitiligo, rheumatoid arthritis, pernicious anemia, skin allergy/atopy, thrombocytopenia, Addison's disease, type 1 diabetes, celiac disease, eosinophilia, etc., The usual treatment of HT is symptomatic with no curative option. Read More

Ann Endocrinol (Paris) 2021 Jun 9. Epub 2021 Jun 9.

Department of Nursing, The Jacob of Paradies University, Gorzów Wielkopolski, Poland.

We present the clinical and molecular studies of a family with Pendred syndrome, in which one affected individual developed follicular thyroid cancer. Two siblings with classic Pendred syndrome triad were operated on because of enormous multinodular goiter. Histopathology showed a follicular thyroid cancer in the male and a multinodular goiter in the female. Read More

BMJ Case Rep 2021 Jun 11;14(6). Epub 2021 Jun 11.

Imperial College Healthcare NHS Trust, London, UK

Hyperthyroidism represents a state of hypercoagulability and hypofibrinolysis, which predisposes an individual to the increased risk of thromboembolism. We present a case of a 25-year-old patient presenting with an acute myocardial infarction secondary to plaque rupture with thrombotic occlusion of proximal left anterior descending artery, in a patient known to have Graves' disease. She had a sudden ventricular fibrillation arrest and a precordial thump given and cardiopulmonary resuscitation started. Read More

Int J Gen Med 2021 3;14:2321-2328. Epub 2021 Jun 3.

Department of Ultrasound, The First Affiliated Hospital of Fujian Medical University, Fuzhou, 350005, People's Republic of China.

Purpose: Ultrasonography as the first choice for thyroid nodules is still difficult to distinguish between solid follicular thyroid neoplasm (FTN) and solid nodular goiter (NG). We tried to investigate the value of relative size (M/S, M: the maximum diameter of target nodule, S: the maximum diameter of the largest of the remaining nodules) that may help to differentiate FTN from NG.

Methods: test and chi-square test were used to retrospectively analyze the differences of the clinical and ultrasonographic characteristics between FTN and NG in 422 cases in our hospital. Read More

Adv Food Nutr Res 2021 24;96:365-415. Epub 2021 Feb 24.

Nutrition Research Division, Bureau of Nutritional Sciences, Food Directorate, Health Products and Food Branch, Health Canada, Sir Frederick G. Banting Research Centre, Ottawa, ON, Canada; Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON, Canada. Electronic address:

Iodine is an essential mineral nutrient and an integral component of thyroid hormones. Iodine deficiency is typically associated with goiter, but can have more serious health implications. Adequate iodine status is important for normal brain development. Read More

Ear Nose Throat J 2021 Jun 9:1455613211024877. Epub 2021 Jun 9.

Department of Otolaryngology-Head and Neck Surgery, Tahar Sfar Hospital, Mahdia, Tunisia.

Extraganglionic Burkitt's lymphoma is rare. Primary thyroid localization accounts for 1% to 5% of malignant tumors of the thyroid gland. The association of Burkitt's lymphoma and pregnancy is even rarer. Read More

Georgian Med News 2021 Apr(313):79-84

1Tyumen State Medical University; Russia.

To search for effective and safe methods aimed at reducing the frequency of surgical treatment for nodular thyroid pathology. 1999-2019 literature review conducted using NLM databases. There is more and more evidence in the literature on the efficacy and safety of minimally invasive treatments for thyroid nodular disease. Read More

Front Endocrinol (Lausanne) 2021 19;12:610573. Epub 2021 May 19.

Department of Thyroid Surgery, School of Medicine, Second Affiliated Hospital of Zhejiang University, Hangzhou, China.

Purpose: Langerhans cell histiocytosis (LCH) is a rare clonal disorder of Langerhans antigen-presenting cells. However, thyroid LCH involvement is relatively rare. We present the first case of spontaneous thyroid hemorrhage due to LCH progression and discuss the clinical features, diagnosis, and treatments of thyroid LCH in a literature review. Read More

BMC Ophthalmol 2021 Jun 5;21(1):251. Epub 2021 Jun 5.

Isfahan Eye Research Center, Department of Ophthalmology, Isfahan University of Medical Sciences, Isfahan, Iran.

Background: To present the very rare comorbidity of developing non-specific orbital inflammation (NSOI) in two patients with histories of definite thyroid eye disease (TED).

Case Presentation: Both patients complained of new-onset progressive proptosis although their thyroid disease was controlled and computed tomography scan revealed an intraorbital inflammatory mass. The pathological assessment indicated that both patients had developed fibrosing NSOI. Read More

Acta Endocrinol (Buchar) 2020 Oct-Dec;16(4):501-504

Izmir Tepecik Training and Research Hospital - General Surgery, Izmir, Turkey.

Background: Langerhans cell histiocytosis (LCH) is a rare group of neoplastic diseases resulting from Langerhans dendritic cells. The most common site (80%) is bones. Thyroid gland involvement is exceedingly rare and usually expected to be seen as a part of multisystemic disease. Read More

Reprod Sci 2021 Jun 2. Epub 2021 Jun 2.

Beijing Key Laboratory of the Innovative Development of Functional Staple and the Nutritional Intervention for Chronic Disease, Department of Clinical Nutrition, Peking Union Medical College Hospital (PUMCH), No. 1 in Shuaifuyuan Street, Dongdan Street, Dongcheng District, Beijing, 100730, China.

The objective of this study is to investigate the impact of preconceptional exposure to oil-based iodinated contrast in the hysterosalpingography (HSG) on pregnant women and their offspring's iodine status, thyroid function, and the outcomes of pregnancy. A cross-sectional evaluation of iodine status was performed on pregnant women with the preconceptional experience of ethiodized-oil HSG. For those found to have iodine excess (with serum iodine concentration (SIC) > 92 μg/L), a prospective follow-up was conducted until termination of the pregnancy or 1 week postpartum. Read More

Br J Hosp Med (Lond) 2021 May 19;82(5):1-2. Epub 2021 May 19.

Anesthesiology, Clinical Research Office, Ataturk University, Erzurum, Turkey.

Rev Assoc Med Bras (1992) 2021 May 31. Epub 2021 May 31.

Hospital Evangélico Mackenzie - Curitiba (PR), Brasil.

Objective: To study the prevalence of Hashimoto's Thyroiditis in a sample of psoriasis patients.

Methods: Cross-sectional observational study of 120 individuals (60 with psoriasis and 60 control subjects) paired by gender and age for thyroid function (thyroid stimulating hormone, free T4), antithyroperoxidase and antithyroglobulin tests and physical examination. Psoriasis Area and Severity Index and Nail Psoriasis Severity Index were evaluated simultaneously. Read More

Nutrients 2021 May 19;13(5). Epub 2021 May 19.

Department of Medical Sciences, University of Torino, 10126 Torino, Italy.

The aim of this observational study was investigating the possible correlation between adherence to the Mediterranean diet (MeD) and SARS-COV-2 infection rates and severity among healthcare professionals (HCPs). An online self-administrated questionnaire (evaluating both MeD adherence and dietary habits) was filled out by HCPs working in Piedmont (Northern Italy) from 15 January to 28 February 2021. Out of the 1206 questionnaires collected, 900 were considered reliable and analyzed. Read More

Pediatr Rep 2021 May 2;13(2):210-215. Epub 2021 May 2.

Pediatric Unit, Department of Pediatrics, "Vittore Buzzi" Children's Hospital, 20154 Milan, Italy.

Congenital goiter is an uncommon cause of neck swelling and it can be associated with hypothyroidism. We discuss a case of primary hypothyroidism with goiter presenting at birth. Ultrasound showed the enlargement of the gland and thyroid function tests detected marked hypothyroidism. Read More

J Clin Med 2021 May 5;10(9). Epub 2021 May 5.

Internal Medicine Department and National Reference Center for Autoinflammatory Diseases and Inflammatory Amyloidosis (CEREMAIA), APHP, Tenon Hospital, Sorbonne University, 4 rue de la Chine, 75020 Paris, France.

Our aim was to describe the main features of amyloid goiter in adults with amyloidosis secondary to familial Mediterranean fever. Therefore, we analyzed cases from a French cohort of familial Mediterranean fever patients with amyloidosis and from literature review. Forty-two cases were identified: 9 from the French cohort and 33 from literature review. Read More

J Chin Med Assoc 2021 Jun;84(6):577-579

Division of General Surgery, Taipei Veterans General Hospital, Taipei, Taiwan, ROC.

Goiter is a disease with history perhaps as long as human has been around. Almost all the available references are in Western language works of literature while information concerning the occurrence of goiter disease in ancient China and the comparison between the treatment in traditional Chinese medicine (TCM) with current Western medicine remains lacking. In this article, the description of goiter, the history of surgical intervention for goiter disease, and the general concept of goiter disease treatment in ancient China literature such as seaweed decoction and acupuncture analgesia for surgery were reviewed. Read More

Radiol Oncol 2021 May 31. Epub 2021 May 31.

Department of Nuclear Medicine, University Medical Centre Ljubljana, LjubljanaSlovenia.

Background: Thyroid nodule diagnosis has become increasingly frequent. Defining optimum surveillance intervals for patients with unsuspicious thyroid nodules remains a challenge. This was a single centre cohort study in which patients diagnosed with unsuspicious thyroid nodules in whom no treatment was indicated were invited for re-evaluation 5 years after the diagnosis. Read More

J Clin Endocrinol Metab 2021 May 29. Epub 2021 May 29.

Department of Military Medicine, Hebrew University, Jerusalem and the Israel Defense Forces Medical Corps, Ramat Gan, Israel.

Context: Thyroid hormones play a key role in systemic metabolism, yet the relationship between thyroid dysfunction and risk for type 2 diabetes is unclear.

Objective: To assess type 2 diabetes risk in adulthood among adolescents with thyroid disorders.

Design And Setting: A nationwide, population-based study of Israeli adolescents who were examined before military recruitment during 1988-2007, and were followed until December 31, 2016. Read More

Biol Trace Elem Res 2021 May 28. Epub 2021 May 28.

Dazhangzhuang Community Health Service Center, 31 Yongkang Road, Beichen District, Tianjin, 300400, People's Republic of China.

We aimed to investigate the relationship between the effects excessive of fluoride on thyroid health in children and the moderating role of thyroid stimulating hormone receptor (TSHR) or protein tyrosine phosphatase nonreceptor-22 (PTPN22) gene polymorphisms. Four hundred thirteen children (141 with dental fluorosis and 198 boys) were enrolled from both historical endemic and non-endemic areas of fluorosis in Tianjin, China. The fluoride exposure levels, thyroid health indicators, and TSHR (rs2268458) and PTPN22 (rs3765598) polymorphisms were examined. Read More

Front Psychol 2021 11;12:667237. Epub 2021 May 11.

Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy.

Emotion-processing impairment represents a risk factor for the development of somatic illness, affecting negatively both health-related quality of life (HRQoL) and disease management in several chronic diseases. The present pilot study aims at (i) investigating the associations between alexithymia and depression, anxiety, and HRQoL in patients with Hashimoto's thyroiditis (HT); (ii) examining the association between these three psychological conditions together with HRQoL, and thyroid autoantibodies status as well as thyroid echotexture in patients with HT; and (iii) comparing the intensity of all these clinical psychological features in patients with HT versus controls. Twenty-one patients with serologically or ultrasonographically verified HT and 16 controls with non-toxic goiter or postsurgical hypothyroidism were recruited for this study. Read More

Surg Technol Int 2021 05 27;38. Epub 2021 May 27.

Division for Endocrine and Minimally Invasive Surgery, Department of Human Pathology in Adulthood and Childhood "G. Barresi", University Hospital G. Martino, University of Messina, Messina, Italy.

Introduction: Post-thyroidectomy hemorrhage is a rare but potentially life-threatening and unpredictable complication of thyroid surgery. Therefore, intraoperative bleeding control and hemostasis are crucial. However, the most efficient, cost-effective, and standardized way to achieve this is not clear. Read More

Indian J Nucl Med 2021 Jan-Mar;36(1):97-99. Epub 2021 Mar 4.

Department of Medicine and Urgency, Nuclear Medicine Unit, "Degli Infermi" Hospital, Ponderano (BI), Italy.

Here, we report a case of a 54-year-old woman affected by thyrotoxicosis, with scintigraphic evidence of a diffuse hyperfunctioning goiter and a large ectopic thyroid tissue in the thyroglossal duct remnant. The latter was apparently more active than the two lobes at Tc-pertechnetate scintigraphy, mimicking a condition of preexisting increased sensitivity to thyroid-stimulating hormone stimulation. On the other hand, single-photon emission computed tomography/computed tomography has proven to be a very useful tool in demonstrating this activity to be similar to the thyroid lobes and in defining extension and anatomical relationships of the mass. Read More

Pediatr Ann 2021 Apr 1;50(4):e143-e147. Epub 2021 Apr 1.

The thyroid plays a major role in growth and development, and the hormones it produces can affect many different systems of the body. For this reason, the thyroid should always be at the front of our minds when evaluating children and adolescents. The symptoms of thyroid abnormalities can often be subtle and evolve over time, so we must have a high index of suspicion when providing care for our patients. Read More

Arch Endocrinol Metab 2021 May;64(5):521-527

Department of Immunology, School of Medicine, Fasa University of Medical Sciences, Fasa, Iran,

Objective: Graves' disease (GD) is an autoimmune disease causing the overproduction of the thyroid hormone from thyroid gland. This disease is mainly the result of the production of antibodies against TSH receptors. Cytokines play an important role in orchestrating the pathophysiology in autoimmune thyroid disease. Read More

Arch Endocrinol Metab 2021 May;64(5):514-520

Endocrinologia e Metabolismo, Hospital da Pontifícia Universidade Católica de Campinas (PUC-Campinas), Campinas, SP, Brasil,

Objective: Graves' disease (GD) is the main cause of hyperthyroidism among adults. It is an autoimmune condition classically marked by the Merserburg Triad (goiter, thyrotoxicosis, and orbitopathy), but the change in presentation of GD over time has rarely been studied. To determine changes in the clinical presentation of patients with GD in the last 30 years. Read More

Arch Endocrinol Metab 2021 May;64(5):507-513

Departamento de Nutrição e Saúde, Universidade Federal de Viçosa (UFV), Viçosa, MG, Brasil.

As pregnant women are susceptible to changes in iodine, which can cause miscarriage, goiter, thyroid nodules, hypothyroidism, in addition to fetal neurological impairment or development. The aim of this study was to verify the implications of the iodine alteration in each gestational trimester and its consequences of physiological justification. The review was based on PRISMA. Read More

Ann Otol Rhinol Laryngol 2021 May 25:34894211014794. Epub 2021 May 25.

Department of Otolaryngology-Head & Neck Surgery, University of Iowa Hospitals & Clinics, Iowa City, IA, USA.

Objective(s): To review the experience of 3 hospitals with airway management during surgery for substernal goiter and identify preoperative factors that predict the need for advanced airway management techniques.

Methods: A retrospective chart review between 2009 and 2017 of patients with substernal goiter treated surgically at 1 of 3 hospitals was performed.

Results: Of the 179 patients included in the study, 114 (63. Read More