577 results match your criteria Goiter Nontoxic


Association between various thyroid gland diseases, TSH values and thyroid cancer: a case-control study.

J Cancer Res Clin Oncol 2020 Jun 9. Epub 2020 Jun 9.

Department of Epidemiology, IQVIA, Unterschweinstiege 2-14, 60549, Frankfurt, Germany.

Background: The goal of this retrospective cohort study was to analyze the association between benign thyroid alteration and thyroid cancer in patients followed in general practices in Germany.

Methods: Patients aged 18-80 who had received an initial diagnosis of thyroid cancer in one of 1261 general practices in Germany between January 2009 and December 2018 were included in this study (index date). These patients were matched (1:1) to non-cancer patients by age, sex, physician and index year. Read More

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http://dx.doi.org/10.1007/s00432-020-03283-xDOI Listing

Endoscopic thyroid lobectomy vs Conventional open thyroid lobectomy.

Pak J Med Sci 2020 May-Jun;36(4):831-835

Dr. Sehrish Altaf, Department of Surgery Ward 25, Jinnah Postgraduate Medical Center, Karachi, Pakistan.

Background And Objective: Surgical managements for these suspicious nontoxic swellings requires open conventional method of thyroidectomy by neck incisions that can result in prominent scars and immediate risk usually hemorrhage. However new technological innovations came into practiced that include video assisted minimal invasive endoscopy by axillo-breast approach that gives very promising results with excellent cosmesis. In this study, we compared conventional open surgery with minimal invasive endoscopic techniques and associate various complaints and complications that were encountered in surgery. Read More

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http://dx.doi.org/10.12669/pjms.36.4.1604DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7260891PMC

Fixed 30 mCi 131I-iodine therapy without recombinant human thyroid-stimulating hormone stimulation as an attractive therapeutic alternative in nontoxic nodular goiter.

Nucl Med Commun 2020 06 9. Epub 2020 Jun 9.

Endocrinology Division.

Objective: To analyze outcomes of patients with compressive nontoxic multinodular goiter after 131I-iodine 30 mCi treatment without previous use of recombinant human thyroid-stimulating hormone or methimazole.

Methods: We evaluated fixed-dose radioiodine therapy outcomes in patients with nontoxic multinodular goiter who did not accept thyroidectomy as a therapeutic option. Laboratory thyroid function and thyroid volume estimated by ultrasound were assessed before and one year after radioiodine therapy. Read More

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http://dx.doi.org/10.1097/MNM.0000000000001213DOI Listing

The Influence of Diffuse Nontoxic Goiter on the State of Protective Mechanisms of the Oral Cavity in Children.

J Med Life 2020 Jan-Mar;13(1):21-25

Department of Medical Biology, I. Horbachevsky Ternopil National Medical University, Ternopil, Ukraine.

Immunopathogenesis of inflammatory and dystrophic diseases of the tissues of the oral cavity is characterized by cellular and humoral factors of specific and nonspecific resistance, the functioning of which is determined by the overall somatic state. This study aimed to study the features of protective mechanisms of the oral cavity due to orthodontic pathology, pathology of periodontal tissues, and odontogenic inflammatory process in children with diffuse nontoxic goiter. Eighty children with diffuse nontoxic goiter aged 12-15 years with different dental status were examined. Read More

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http://dx.doi.org/10.25122/jml-2020-0013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7175437PMC

Quality of life is not affected by thyroid surgery in nontoxic benign goitre in long-term surveillance-A prospective observational study.

Endocrinol Diabetes Metab 2020 Apr 26;3(2):e00115. Epub 2020 Feb 26.

University Hospital for Visceral Surgery Medical Campus University of Oldenburg Pius-Hospital Oldenburg Germany.

Objective: Quality of life (QoL) has so far seldom been taken into account by default in decision-making for surgical indication in thyroid surgery. Therefore, we compared pre- and postoperative QoL of patients using the EuroQoL-5D (EQ-5D) questionnaire. The influence of certain socio-economic factors on QoL as a second end-point was considered. Read More

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http://dx.doi.org/10.1002/edm2.115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7170450PMC

The artist's wife with a simple nontoxic goiter.

J Endocrinol Invest 2020 Jul 6;43(7):1043-1044. Epub 2020 Mar 6.

Endocrine Unit, Department of Medicine & Surgery, University of Insubria, ASST dei Sette Laghi, Varese, Italy.

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http://dx.doi.org/10.1007/s40618-020-01206-8DOI Listing

Benign Thyroid Diseases: Are There Gender-Specific Differences for Diagnosis and Treatment of Nontoxic Thyroid Nodules? Results from a 4-Year Retrospective Analysis of an Endocrine Tumor Board.

Visc Med 2020 Feb 21;36(1):28-33. Epub 2020 Jan 21.

Department of General, Visceral, Cancer and Transplantation Surgery, University of Cologne, Cologne, Germany.

Introduction: Benign nodular goiters are endemic in Germany and diagnostic thyroidectomy is one of the most frequent surgical procedures. Less than 10% result in a malignant finding which is a poor ratio in comparison to other European countries. There is a female preponderance in almost all thyroid pathologies according to the current literature but not much is known concerning gender-specific differences in thyroid nodules. Read More

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http://dx.doi.org/10.1159/000505499DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7036535PMC
February 2020

AMYLOID GOITER AS THE FIRST RECOGNIZABLE MANIFESTATION OF IMMUNOGLOBULIN LIGHT CHAIN AMYLOIDOSIS.

AACE Clin Case Rep 2019 Sep-Oct;5(5):e326-e329. Epub 2019 Jun 26.

Objective: Clinically apparent thyroid enlargement due to massive amounts of amyloid deposition, known as amyloid goiter, is rare. Endocrinologists should become familiar with this manifestation of systemic amyloidosis, which may be diagnosed by Congo red staining of the specimen obtained by fine-needle aspiration.

Methods: We describe a 70-year-old man who presented with a slowly enlarging goiter. Read More

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http://dx.doi.org/10.4158/ACCR-2019-0161DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6876951PMC

Therapeutic Effect of Curcumin, a Plant Polyphenol Extracted From Curcuma longae, in Fibroblasts From Patients With Graves' Orbitopathy.

Invest Ophthalmol Vis Sci 2019 10;60(13):4129-4140

Department of Ophthalmology, Severance Hospital, Institute of Vision Research, Yonsei University College of Medicine, Seoul, Korea.

Purpose: We examined the therapeutic effect of nontoxic concentrations of curcumin, a plant polyphenol extracted from Curcuma longae, in primary cultures of orbital fibroblasts from Graves' orbitopathy (GO).

Methods: The effect of curcumin on interleukin (IL)-1β induced-proinflammatory cytokine production was determined using quantitative real-time PCR, enzyme-linked immunosorbent assay (ELISA), and Western blot analysis. Adipogenic differentiation was identified using Oil-Red O staining, and levels of peroxisome proliferator activator γ (PPARγ) and CCAAT-enhancer-binding proteins (C/EBP) α/β were determined by Western blot analyses. Read More

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http://dx.doi.org/10.1167/iovs.19-27376DOI Listing
October 2019
1 Read
3.404 Impact Factor

Elevated serum concentrations of IGF-1 and IGF-1R in patients with thyroid cancers.

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 2020 Mar 23;164(1):77-83. Epub 2019 May 23.

Clinic of Endocrinological and General Surgery, Chair of Endocrinology, Medical University of Lodz, Pabianicka 62, 93-513 Lodz, Poland.

Background: The rising incidence of thyroid cancer observed in the last few decades requires an improvement in diagnostic tools and management techniques for patients with thyroid nodules.

Aims: The aim of this study was to assess serum concentrations of IGF-1 and IGF-1R in patients diagnosed with thyroid cancers.

Methods: 36 patients diagnosed with papillary thyroid cancer (PTC), 11 subjects with follicular thyroid cancer (FTC), 9 patients with anaplastic thyroid cancer (ATC) and 19 subjects with multinodular nontoxic goiter (MNG) were enrolled to the study. Read More

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http://dx.doi.org/10.5507/bp.2019.018DOI Listing
March 2020
5 Reads

Toxic nodular goiter and thyroid cancer: Is hyperthyroidism protective against thyroid cancer?

Surgery 2019 09 16;166(3):356-361. Epub 2019 May 16.

Department of Endocrinology and Metabolism, Ankara Yıldırım Beyazıt University Faculty of Medicine, Ankara, Turkey.

Background: The suppressive effect of the increase in thyroid hormone in patients with toxic nodular goiter is thought to protect the extranodular thyroid tissue from thyroid malignancy. In this study, we aimed to evaluate the prevalence and features of thyroid cancer in patients with toxic nodular goiter who underwent thyroidectomy.

Methods: Medical data of patients who had solitary toxic or nontoxic nodules and underwent total thyroidectomy were reviewed retrospectively. Read More

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http://dx.doi.org/10.1016/j.surg.2019.03.012DOI Listing
September 2019
7 Reads

Response to: Hemithyroidectomy should be the procedure of choice for nontoxic benign unilateral goiters.

Surgery 2019 11 13;166(5):954-955. Epub 2019 May 13.

Department of Visceral and Endocrine Surgery, CHU Poitiers, Poitiers, France. Electronic address:

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http://dx.doi.org/10.1016/j.surg.2019.03.009DOI Listing
November 2019
1 Read
3.380 Impact Factor

Hemithyroidectomy should be the procedure of choice for nontoxic benign unilateral goiters.

Surgery 2019 11 28;166(5):954. Epub 2019 Mar 28.

Department of General Surgery, All India Institute of Medical Sciences, Patna, India. Electronic address:

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http://dx.doi.org/10.1016/j.surg.2019.02.015DOI Listing
November 2019
3.380 Impact Factor

[Diagnoses of thyroid disorders in ENT and general practices in Germany between 2008 and 2016].

HNO 2018 Dec;66(12):922-928

Klinik für Hals-Nasen-Ohrenheilkunde, Kopf- und Halschirurgie, Städtisches Klinikum Solingen, Solingen, Deutschland.

Objective: The aim of this study was to investigate thyroid disorder diagnoses in otorhinolaryngologic (ENT) practices in Germany compared to general (GP) practices using data from a representative Germany-wide practice database.

Methods: The database was retrospectively searched for diagnoses of thyroid disorders made in ENT and GP practices between January 2008 and December 2016. Data were collected on the most common three-character disease classes (categories) from the "Disorders of thyroid gland" (E00-E07) group as well as the "Benign neoplasm of thyroid gland" (D34) and "Malignant neoplasm of thyroid gland" (C73) categories. Read More

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http://link.springer.com/10.1007/s00106-018-0575-5
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http://dx.doi.org/10.1007/s00106-018-0575-5DOI Listing
December 2018
13 Reads

Transient Hyperthyroidism Induced by Thyroid Ultrasound.

Ann Otol Rhinol Laryngol 2018 Aug 17;127(8):558-562. Epub 2018 Jun 17.

1 Section of Endocrinology and Metabolism, Department of Internal Medicine, Louisiana State University Health Sciences Center in Shreveport, Shreveport, Louisiana, USA.

Objectives: Transient hyperthyroidism has been documented following surgical manipulation or direct trauma to the normal thyroid gland. This has best been studied in patients following parathyroidectomy and also reported following trauma to the neck, strangulation, and vigorous palpation of the thyroid gland. It has not previously been reported following a thyroid ultrasound. Read More

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http://dx.doi.org/10.1177/0003489418781169DOI Listing
August 2018
38 Reads

Nontoxic Multinodular Goitre and Incidental Thyroid Cancer: What Is the Best Surgical Strategy?-A Retrospective Study of 2032 Patients.

Int J Endocrinol 2018 14;2018:4735436. Epub 2018 May 14.

First Department and Clinic of General, Gastroenterological and Endocrine Surgery, Wroclaw Medical University, Maria Sklodowska-Curie Street 66, 50-369 Wroclaw, Poland.

Objectives: A discussion with regard to the most optimal surgical procedure in nontoxic multinodular goitre (NTMNG). We assessed and compared three main types of operations in 2032 patients with NTMNG.

Methods: This is a retrospective study of 2032 patients operated on in one center due to NTMNG. Read More

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http://dx.doi.org/10.1155/2018/4735436DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5977011PMC
May 2018
18 Reads

Nontoxic Goiter (NTG) and Radioiodine: What Do Patients Think About It? Quality of Life in Patients with NTG Before and After 131-I Therapy.

Front Endocrinol (Lausanne) 2018 16;9:114. Epub 2018 Apr 16.

Department of Endocrinology and Internal Medicine, Medical University of Gdansk, Gdansk, Poland.

Objective: Despite numerous publications regarding nontoxic goiter (NTG) treatment and an increasing interest in patients' quality of life, few studies present the outcome of 131-I treatment from the patients' perspective. Our study's main aim was to verify whether there is any improvement in life quality following 131-I treatment.

Materials And Methods: Thirty-five patients with NTG qualified to participate in the study. Read More

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http://dx.doi.org/10.3389/fendo.2018.00114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5912045PMC
April 2018
26 Reads

Benign Thyroid Diseases and Risk of Thyroid Cancer: A Nationwide Cohort Study.

J Clin Endocrinol Metab 2018 06;103(6):2216-2224

Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus C, Denmark.

Context: Thyroid nodules, adenomas, and goiter have consistently been associated with thyroid cancer risk. Few studies have assessed whether thyroid dysfunction and thyroid autoimmunity influence this risk.

Objective: To examine thyroid cancer risk after diagnoses of a wide range of benign thyroid conditions. Read More

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http://dx.doi.org/10.1210/jc.2017-02599DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276704PMC
June 2018
8 Reads

Alteration in the serum concentrations of FGF19, FGFR4 and βKlotho in patients with thyroid cancer.

Cytokine 2018 05 10;105:32-36. Epub 2018 Feb 10.

Department of Immunoendocrinology, Chair of Endocrinology, Medical University of Lodz, Sterlinga 3, 91-425 Lodz, Poland.

Introduction: βKlotho (βKL) is known to act as co-receptor for fibroblast growth factor receptor 4 (FGFR4) which is the main cognate receptor for fibroblast growth factor 19 (FGF19). Dysregulation of this FGF19/FGFR4/βKL signaling axis has been implicated in the pathogenesis of several cancers. However, its role in the pathogenesis of thyroid cancer has not been determined. Read More

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http://dx.doi.org/10.1016/j.cyto.2018.02.013DOI Listing
May 2018
17 Reads

Cancer Frequency in Retrosternal Goiter.

Am Surg 2017 Dec;83(12):1390-1393

Retrosternal goiter prevalence is 5 to 40 per cent according to classifications in goiter series. Goiters with mediastinal extension were reported to be related with higher cancer rates. In our study, we aimed to investigate whether cancer incidence increased in retrosternal goiters compared with the cervical ones. Read More

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December 2017
17 Reads

The association between irisin and muscle metabolism in different thyroid disorders.

Clin Endocrinol (Oxf) 2018 03 20;88(3):460-467. Epub 2017 Dec 20.

Department of Endocrinology, Metabolism and Internal Medicine, Poznań University of Medical Sciences, Poznań, Poland.

Background: Irisin is a new adipo-myokine, encoded by the FNDC5 gene. Currently, there is a discussion regarding the relation between thyroid function and irisin concentration. This prospective study assesses the influence of thyrometabolic changes on serum irisin concentration in association with altered muscle metabolism. Read More

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http://dx.doi.org/10.1111/cen.13527DOI Listing
March 2018
33 Reads

Quality of life after thyroidectomy in patients with nontoxic nodular goiter: A prospective cohort study.

Head Neck 2017 11 4;39(11):2232-2240. Epub 2017 Sep 4.

Department of ORL Head & Neck Surgery, Odense University Hospital, Odense, Denmark.

Background: Using the thoroughly validated Thyroid-Related Quality-of-Life Patient-Reported Outcome (ThyPRO) questionnaire, the purpose of this study was to investigate changes in disease-specific quality of life (QOL) after surgical treatment in patients with benign nontoxic multinodular goiters.

Method: Patients with goiters scheduled for thyroid surgery (n = 106) and individuals from the general population (n = 739) were studied. The ThyPRO data before, 3 months, and 6 months after surgery were compared with normative scores from the general population using a linear mixed model and t tests. Read More

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http://dx.doi.org/10.1002/hed.24886DOI Listing
November 2017
20 Reads

The Concomitant Association of Thyroid Disorders and Myasthenia Gravis.

Transl Neurosci 2017 30;8:27-30. Epub 2017 Apr 30.

Division of Endocrinology and Metabolism, Department of Internal Medicine, Taipei Medical University Hospital, Taipei, Taiwan.

Background: Some of the thyroid disorders (TD) and Myasthenia gravis (MG) are autoimmune related disease. The purpose of the study to evaluate the relationship of MG with all morphological and functional thyroid disorders.

Methods: We constructed a population-based cohort study during the period from January 2000-December 2002 by using reimbursement data from the Bureau National Health Insurance (NHI) system in Taiwan. Read More

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http://dx.doi.org/10.1515/tnsci-2017-0006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5443889PMC
April 2017
23 Reads

Increased Cardiovascular Mortality and Morbidity in Patients Treated for Toxic Nodular Goiter Compared to Graves' Disease and Nontoxic Goiter.

Thyroid 2017 07 5;27(7):878-885. Epub 2017 Jun 5.

6 Department of Clinical Research and Education, Sodersjukhuset, Karolinska Institutet , Stockholm, Sweden .

Background: Previous research has suggested an increased risk of death and cardiovascular disease in patients treated for hyperthyroidism. However, studies on this subject are heterogeneous, often based on old data, or have not considered the impact that treatment for hyperthyroidism might have on cardiovascular risk. It is also unclear whether long-term prognosis differs between Graves' disease and toxic nodular goiter. Read More

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http://dx.doi.org/10.1089/thy.2017.0029DOI Listing
July 2017
40 Reads

Neglected nontoxic multinodular goiter presented as a large neck mass.

Clin Case Rep 2017 Mar 20;5(3):357-358. Epub 2016 Dec 20.

Department of Anatomy-Histology-Embryology University of Ioannina School of Medicine Ioannina Greece.

Large multinodular goiters, obvious to the naked eye, are rarely confronted by clinicians nowadays; yet they do have a place in the differential diagnosis of the neck masses. Due to the fact that 80% of the neck masses in adults are related to malignancy, the later should be ruled out. Read More

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http://dx.doi.org/10.1002/ccr3.771DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5331211PMC
March 2017
8 Reads

Elevated Concentrations of SERPINE2/Protease Nexin-1 and Secretory Leukocyte Protease Inhibitor in the Serum of Patients with Papillary Thyroid Cancer.

Dis Markers 2017 31;2017:4962137. Epub 2017 Jan 31.

Department of Immunoendocrinology, Chair of Endocrinology, Medical University of Lodz, Sterlinga 3, 91-425 Lodz, Poland.

. SERPINE2 and secretory leukocyte protease inhibitor (SLPI) are proteins with anticoagulant properties which could promote solid tumor growth. However, their role in the pathogenesis of thyroid cancer has not been determined. Read More

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http://dx.doi.org/10.1155/2017/4962137DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5306996PMC
March 2017
39 Reads

Deep Sequencing Reveals Spatially Distributed Distinct Hot Spot Mutations in DICER1-Related Multinodular Goiter.

J Clin Endocrinol Metab 2016 10 26;101(10):3637-3645. Epub 2016 Jul 26.

Departments of Human Genetics (L.d.K., M.K.W., W.D.F.), Pathology (I.B.), Oncology (W.D.F.), McGill University; Department of Medical Genetics, Lady Davis Institute, Segal Cancer Centre, Jewish General Hospital (L.d.K., M.K.W., N.S., W.D.F.); Research Institute of the McGill University Health Centre (L.d.K., W.D.F.); McGill University and Genome Québec Innovation Centre (T.R., P.B., J.R.), Montréal, Québec, Canada; and (J.R.P.), Minneapolis, Minnesota, USA.

Context: Nontoxic multinodular goiter (MNG) occurs frequently, but its genetic etiology is not well established. Familial MNG and MNG occurring with ovarian Sertoli-Leydig cell tumor are associated with germline DICER1 mutations. We recently identified second somatic DICER1 ribonuclease (RNase) IIIb mutations in two MNGs. Read More

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http://dx.doi.org/10.1210/jc.2016-1328DOI Listing
October 2016
48 Reads

Intrathoracic toxic thyroid nodule causing hyperthyroidism with a multinodular normal functional cervical thyroid gland.

Indian J Nucl Med 2016 Jul-Sep;31(3):229-31

Department of Nuclear Medicine, Medical Faculty, Trakya University, Edirne, Turkey.

Radionuclide scintigraphy with I-131 and Tc-99m pertechnetate ((99)mTc04) has been widely used in detecting toxic nodules. Intrathoracic goiter usually presents as an anterior mediastinal mass. Mostly the connection between intrathoracic mass and the cervical thyroid gland is clearly and easily identified occurring as a result of inferior extension of thyroid tissue in the neck, which is called as secondary intrathoracic goiter. Read More

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http://dx.doi.org/10.4103/0972-3919.183617DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4918492PMC
July 2016
11 Reads

Total Thyroidectomy versus Bilateral Subtotal Thyroidectomy for Bilateral Multinodular Nontoxic Goiter: A Meta-Analysis.

ORL J Otorhinolaryngol Relat Spec 2016 3;78(3):167-75. Epub 2016 Jun 3.

Department of Surgical Oncology, Ningbo No. 2 Hospital, Ningbo, China.

Aim: The aim of this meta-analysis is to assess and validate the feasibility and safety of total thyroidectomy (TT) when compared to bilateral subtotal thyroidectomy (BST) for bilateral multinodular nontoxic goiter (BMNG).

Materials And Methods: PubMed, Web of Knowledge, and Ovid's database were searched for studies published in English language between January 1990 and December 2014. A meta-analysis was performed to compare the complications and recurrences of TT versus BST. Read More

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http://dx.doi.org/10.1159/000444644DOI Listing
August 2017
8 Reads

Radioiodine Therapy Does Not Change the Atherosclerotic Burden of the Carotid Arteries.

Thyroid 2016 07 20;26(7):965-71. Epub 2016 May 20.

4 Department of Clinical Physiology and Nuclear Medicine, University Hospital of Herlev , Herlev, Denmark .

Background And Aim: Atherosclerosis evolves or accelerates when arteries are exposed to ionizing radiation, both early and late after exposure. Radioiodine therapy of benign thyroid disease exposes the carotid arteries to 4-50 Gy, and may thereby increase the risk of atherosclerosis. Increased risk of cerebrovascular events has been reported after radioiodine therapy. Read More

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http://dx.doi.org/10.1089/thy.2015.0538DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4939365PMC
July 2016
20 Reads

The Rate and Clinical Significance of Incidental Thyroid Uptake as Detected by Gallium-68 DOTATATE Positron Emission Tomography/Computed Tomography.

Thyroid 2016 06 6;26(6):831-5. Epub 2016 May 6.

1 Endocrine Oncology Branch, National Cancer Institute, National Institutes of Health , Bethesda, Maryland.

Background: Gallium-68 (Ga-68) DOTATATE is a radiolabeled peptide-imaging modality that targets the somatostatin receptor (SSTR), especially subtype 2 (SSTR2). Benign and malignant thyroid tumors have been observed to express SSTR. The aim of this study was to evaluate the frequency and clinical significance of incidental atypical thyroid uptake as detected by Ga-68 DOTATATE positron emission tomography/computed tomography (PET/CT). Read More

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http://dx.doi.org/10.1089/thy.2016.0174DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4913484PMC
June 2016
117 Reads

[IMPACT ON DIFFERENTIATED THERAPY OF SOMATIC AND SEXUAL DEVELOPMENT OF ADOLESCENTS WITH DIFFUSE NONTOXIC GOITER].

Authors:
S I Turchina

Lik Sprava 2015 Jul-Sep(5-6):87-93

Results of complex inspection of 163 girls and 192 boys of 8-17 years with the diffusion not toxic craw (DNG) are presented. At 59.4% of patients revealed disharmonious physical development. Read More

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May 2016
16 Reads

Graves' disease in a mediastinal mass presenting after total thyroidectomy for nontoxic multinodular goiter: a case report.

J Med Case Rep 2016 Mar 31;10:70. Epub 2016 Mar 31.

Serviço de Endocrinologia, Diabetes e Metabolismo, Centro Hospitalar de São João, Alameda Professor Hernâni Monteiro, 4202-451, Porto, Portugal.

Background: Thyrotoxicosis after total thyroidectomy is mostly iatrogenic. Rarely, a hyperfunctional thyroid remnant or ectopic tissue may be the cause. There are few cases of Graves' disease arising from thyroid tissue located in the mediastinum and none in which Graves' disease was diagnosed only after surgery. Read More

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http://dx.doi.org/10.1186/s13256-016-0878-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4815244PMC
March 2016
20 Reads

Single, very low dose (0.03 mg) of recombinant human thyrotropin (rhTSH) effectively increases radioiodine uptake in the I-131 treatment of large nontoxic multinodular goiter.

Nucl Med Rev Cent East Eur 2016 ;19(1):3-11

Nuclear Medicine Department, Medical University of Bialystok, Poland.

Background: Radioiodine therapy (RIT) in patients with large nontoxic multinodular goiter (MNG) recently becomes more common method in comparison to surgery (especially in elderly patients and with contraindications because of severe chronic diseases other systems). Repeatedly low thyroid radioactive iodine uptake (RAIU) decreases effectiveness of RIT or makes it impossible. The recombinant human thyrotropin can increase RAIU and improve the results of RIT. Read More

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http://dx.doi.org/10.5603/NMR.2016.0002DOI Listing
October 2016
40 Reads

PREVALENCE OF NONTOXIC NODULAR GOITER AFTER A NEARLY TWO-DECADE UNIVERSAL SALT IODIZATION IN A LITTORAL REGION OF SHANDONG PROVINCE, CHINA.

Acta Endocrinol (Buchar) 2016 Jan-Mar;12(1):43-46

Weihai Municipal Hospital affiliated to Dalian Medical University, Department of Clinical Lab, Shandong, PR China.

Introduction: With the introduction of iodized salt, more and more people are exposed to iodine sufficiency in some regions. The purpose of this study was to investigate the prevalence of nontoxic nodular goiter (NTNG) in the littoral region with high iodine supply after a nearly two- decade universal salt iodization.

Subjects And Methods: Eight hundred and thirty- five participants (from 25~65 years; males 421 and females 414) were invited for the study from Huan-cui District of Weihai City, Shandong Province from January 2013 to September 2014. Read More

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http://dx.doi.org/10.4183/aeb.2016.43DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6586744PMC
July 2019
3 Reads

[The problem of iodine deficiency and its solution in the republic of Belarus].

Gig Sanit 2016 ;95(5):417-21

The problem of iodine deficiency is relevant to the Republic of Belarus. It’s confirmed by virtually commonly found geophysical iodine deficiency in soils and waters. Data on iodine deficiency initiated the development of a state strategy for the elimination of iodine deficiency in the population. Read More

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March 2018
9 Reads

Surgical Management of Nontoxic Multinodular Goiter: Is the Jury Still Out?

Indian J Surg 2015 Aug 30;77(4):341-2. Epub 2015 Jun 30.

Department of General Surgery, All India Institute of Medical Sciences, Raipur, Chhattisgarh 492099 India.

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http://dx.doi.org/10.1007/s12262-015-1310-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4688260PMC
August 2015
9 Reads

A Prospective Study on Cardiovascular Dysfunction in Patients with Hyperthyroidism and Its Reversal After Surgical Cure.

World J Surg 2016 Mar;40(3):622-8

Department of Endocrine Surgery, Madras Medical College, Chennai, India.

Background: Cardiovascular dysfunction (CVD) is a major cause of mortality and morbidity in hyperthyroidism. CVD and its reversibility after total thyroidectomy (TT) are not adequately addressed. This prospective case-control study evaluates the effect of hyperthyroidism on myocardium and its reversibility after TT. Read More

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http://dx.doi.org/10.1007/s00268-015-3352-6DOI Listing
March 2016
35 Reads

PRDM1 expression via human parvovirus B19 infection plays a role in the pathogenesis of Hashimoto thyroiditis.

Hum Pathol 2015 Dec 10;46(12):1913-21. Epub 2015 Sep 10.

Department of Pathology, State Key Laboratory of Cancer Biology, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, PR China. Electronic address:

Ectopic lymphoid follicle infiltration is a key event in Hashimoto thyroiditis (HT). Positive regulatory domain zinc finger protein 1 (PRDM1), which is induced by antigen stimulation, can regulate all lymphocyte lineages. Several groups independently demonstrated that human parvovirus B19 (PVB19) is closely associated with HT. Read More

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http://dx.doi.org/10.1016/j.humpath.2015.08.009DOI Listing
December 2015
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The feasibility of low-dose oral lithium therapy and its effect on thyroidal radioiodine uptake, retention, and hormonal parameters in various subcategories of hyperthyroid patients: a pilot study.

Nucl Med Commun 2016 Jan;37(1):74-8

Radiation Medicine Centre, Bhabha Atomic Research Centre, Tata Memorial Hospital Annexe, Mumbai, Maharashtra, India.

Background: Radioactive iodine (I) (RAI) is used widely for the treatment of hyperthyroidism either as a first-line treatment or following relapse after antithyroid drug treatment. Intrathyroidal retention of RAI is considered an important determinant of its effectiveness, which is believed to be prolonged by lithium.

Aims And Objectives: To study the impact of low-dose oral lithium therapy on RAI uptake and retention parameters in different subgroups of hyperthyroidism patients, and thus explore its potential role in enhancing the therapeutic efficacy of RAI in these groups of patients. Read More

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http://pdfs.journals.lww.com/nuclearmedicinecomm/2016/01000/
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http://dx.doi.org/10.1097/MNM.0000000000000414DOI Listing
January 2016
45 Reads
2 Citations
1.371 Impact Factor

Etiopathology, clinical features, and treatment of diffuse and multinodular nontoxic goiters.

Authors:
M Knobel

J Endocrinol Invest 2016 Apr 21;39(4):357-73. Epub 2015 Sep 21.

Thyroid Unit, Division of Endocrinology and Metabolism, Hospital das Clínicas, University of São Paulo Medical School, Av. Dr. Enéas de Carvalho Aguiar, 155 - 8th floor, bl 3, PAMB, São Paulo, 05403-900, Brazil.

Goiter, an enlargement of the thyroid gland, is a common problem in clinical practice associated with iodine deficiency, increase in serum thyroid-stimulating hormone (TSH) level, natural goitrogens, smoking, and lack of selenium and iron. Evidence suggests that heredity also has an important role in the etiology of goiter. The current classification divides goiter into diffuse and nodular, which may be further subdivided into toxic (associated with symptoms of hyperthyroidism, suppressed TSH or both), or nontoxic (associated with a normal TSH level). Read More

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http://link.springer.com/content/pdf/10.1007/s40618-015-0391
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http://link.springer.com/10.1007/s40618-015-0391-7
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http://dx.doi.org/10.1007/s40618-015-0391-7DOI Listing
April 2016
18 Reads

Assessing perioperative body weight changes in patients thyroidectomized for a benign nontoxic nodular goitre.

Clin Endocrinol (Oxf) 2016 06 19;84(6):882-8. Epub 2015 Oct 19.

School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.

Background: Following thyroidectomy, patients often complain of weight gain. Our study aimed to evaluate the extent of weight change in patients thyroidectomized for a nontoxic benign goitre after adjusting for patient demographics and pre-operative weight changes.

Methods: Three different patient groups were studied. Read More

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http://doi.wiley.com/10.1111/cen.12945
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http://dx.doi.org/10.1111/cen.12945DOI Listing
June 2016
19 Reads

Postoperative Acute Respiratory Failure In Patients Treated Surgically For Goiters.

Pol Przegl Chir 2015 Jul;87(7):331-5

Unlabelled: The aim of the study was to present a clinical picture, treatment and prognosis regarding patients who developed acute respiratory failure (ARF) while treated surgically for a goiter.

Material And Methods: A total of 3810 patients were treated for goiters between 2008 to 2013. Symptoms of postoperative ARF were recognized in 39 (1%) patients. Read More

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http://dx.doi.org/10.1515/pjs-2015-0065DOI Listing
July 2015
38 Reads

Large multinodular goiter--outpatient radioiodine treatment.

Endokrynol Pol 2015 ;66(4):301-7

Department of Endocrinology and Internal Medicine, Medical University of Gdansk, Gdansk, Poland.

Introduction: 131-I treatment of nodular, especially nontoxic, goitre is still reserved mainly for elderly patients, whose numerous concomitant diseases disqualify them from surgery. Therapy often involves isolation and is available only in selected centres, which may be located far from some patients' places of residence, which is inconvenient for elderly people. The aim of the study was to assess the effectiveness of outpatient fractionated 131-I treatment of patients with large nodular goitres, as well as to evaluate complications and the factors affecting treatment results. Read More

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http://dx.doi.org/10.5603/EP.2015.0038DOI Listing
February 2017
31 Reads

Bone Indices in Thyroidectomized Patients on Long-Term Substitution Therapy with Levothyroxine Assessed by DXA and HR-pQCT.

J Thyroid Res 2015 13;2015:796871. Epub 2015 Jul 13.

Department of Endocrinology and Internal Medicine, THG, Aarhus University Hospital, 8000 Aarhus C, Denmark.

Background. Studies on bone effects of long-term substitution therapy with levothyroxine (LT4) have shown discrepant results. Previous studies have, however, not evaluated volumetric bone mineral densities (vBMD), bone structure, and strength using high resolution peripheral quantitative computed tomography (HR-pQCT) and finite element analysis (FEA). Read More

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http://dx.doi.org/10.1155/2015/796871DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4515520PMC
August 2015
21 Reads

B Cell Activating Factor (BAFF) and BAFF Receptor Expression in Autoimmune and Nonautoimmune Thyroid Diseases.

Thyroid 2015 Sep 13;25(9):1043-9. Epub 2015 Aug 13.

1 Graves' Orbitopathy Center , Endocrinology Unit, Department of Clinical Sciences and Community Health, Ospedale Maggiore Policlinico of Milan and Università degli Studi di Milano , Milan, Italy .

Background: The B cell activating factor (BAFF) is a member of the tumor necrosis factor family, which controls the survival/proliferation of B cells and is involved in the pathogenesis of a number of autoimmune diseases. The objective of the present study was to investigate the expression of BAFF and BAFF receptor (BAFF-R) in the thyroid tissue of patients affected with autoimmune thyroid disorders (AITD) or multinodular goiter (MNG) compared with those with normal thyroids.

Methods: Immunohistochemistry was performed using a panel of antibodies against BAFF, BAFF-R, CD3, CD4, CD8, CD20, CD34, CD79a, CD1a, CD68, and CD163 on the thyroid sections of 27 patients affected with Graves' disease (GD), 23 with Hashimoto's thyroiditis (HT), 16 with nontoxic nodular goiter (NTG), and 15 with toxic nodular goiter (TG), submitted to total thyroidectomy between 2000 and 2011. Read More

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http://dx.doi.org/10.1089/thy.2015.0029DOI Listing
September 2015
41 Reads

High Frequency of Thyroid Disorders in Patients Presenting With Neutropenia to an Outpatient Hematology Clinic STROBE-Compliant Article.

Medicine (Baltimore) 2015 Jun;94(23):e886

From the Division of Endocrinology, Metabolism and Diabetes, First Department of Pediatrics, National and Kapodistrian University of Athens, University of Athens Medical School, "Aghia Sophia" Children's Hospital, (EMK); Hematology Clinic, Athens Medical Center, Psychiko Branch, Athens (XY, GAP); Department of Hematology, University of Crete School of Medicine, Heraklion, Crete (CP, KP, CK, IM, HK, SM, HAP); Department of Hematology and BMT, National and Kapodistrian University of Athens, Laikon General Hospital (TPV, MKA); First Department of Internal Medicine, National and Kapodistrian University of Athens, Laikon General Hospital (GV); and Third Department of Internal Medicine, Medical School, University of Athens, Sotiria General Hospital, Athens, Greece (ED-K).

Granulopoiesis abnormalities have been described in association with thyroid disorders (TD). However, data regarding systematic evaluation of adult neutropenia and concurrent or prior TD are scarce. To investigate the frequency of TD among patients presenting with neutropenia, and the immunophenotypic and immunologic profile of neutropenic patients with concomitant thyroidopathy. Read More

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http://dx.doi.org/10.1097/MD.0000000000000886DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4616464PMC
June 2015
35 Reads

Is Preoperative Vitamin D Deficiency a Risk Factor for Postoperative Symptomatic Hypocalcemia in Thyroid Cancer Patients Undergoing Total Thyroidectomy Plus Central Compartment Neck Dissection?

Thyroid 2015 Aug 17;25(8):911-8. Epub 2015 Jun 17.

1 Department of Surgery, Institute of Endocrine Research, Yonsei University Health System , Seoul, Korea.

Background: Although some studies have reported that preoperative vitamin D deficiency (VDD) is a risk factor for hypocalcemia after total thyroidectomy (TT) in patients with nontoxic multinodular goiter or Graves' disease, the association between VDD and postoperative hypocalcemia in thyroid cancer patients undergoing TT plus central compartment neck dissection (CCND) remains unclear. This study evaluated whether preoperative VDD was associated with postoperative symptomatic hypocalcemia.

Materials And Methods: Data were collected prospectively between September 2012 and May 2013. Read More

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http://dx.doi.org/10.1089/thy.2014.0522DOI Listing
August 2015
35 Reads