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J Surg Res 2022 May 17;278:93-99. Epub 2022 May 17.

Division of Endocrine Surgery; DeWitt Daughtry Department of Surgery, University of Miami Leonard M. Miller School of Medicine, Miami, Florida.

Introduction: With increasing rates of obesity worldwide, a correlation between high body mass index (BMI) and postoperative morbidity after thyroid surgery remains unclear. Postoperative transient hypocalcemia is common after total thyroidectomy due to interruption of parathyroid function. This study examines the relationship between BMI and hypocalcemia after total thyroidectomy. Read More

Gastrointest Tumors 2022 Mar 4;9(1):37-42. Epub 2021 Nov 4.

Department of Hepatology and Gastroenterology, Aarhus University Hospital, Aarhus, Denmark.

Introduction: Hepatocellular carcinoma (HCC) is the fourth leading cause of cancer mortality worldwide. Recent animal studies suggest that thyroid hormone treatment improves HCC prognosis. The aim of this study was to describe the association between thyroid disease and HCC prognosis in humans. Read More

Sisli Etfal Hastan Tip Bul 2022 28;56(1):21-40. Epub 2022 Mar 28.

Division of Endocrine Surgery, Department of General Surgery, University of Health Sciences Turkey, Sisli Hamidiye Etfal Training and Research Hospital, Istanbul, Turkey.

Goiter term is generally used for defining the enlargement of thyroid gland. Thyroid nodules are very common and some of these nodules may harbor malignancy. Multinodular goiter (MNG) disease without thyroid dysfunction is defined as non-toxic MNG. Read More

Sci Rep 2022 04 22;12(1):6620. Epub 2022 Apr 22.

Department of Obstetrics and Gynecology, Sanggye Paik Hospital, Inje University College of Medicine, Seoul, Republic of Korea.

Uterine fibroid and benign thyroid disease are both common diseases in women. This study aimed to evaluate whether these diseases are related. We established the uterine fibroid group according to diagnosis and surgery codes using the Korea National Health Insurance data from 2009 to 2020. Read More

Pol Merkur Lekarski 2022 Apr;50(296):94-98

Department of Pathologic Physiology, Bukovinian State Medical University, Chernivtsi, Ukraine.

Type 2 diabetes mellitus (T2DM) patient outcomes, treatment options, and corresponding healthcare expenses are affected by the presence of different comorbidities.

Aim: The aim of this work was to develop an algorithm for predicting the risk of diffuse non-toxic goitre development in patients with T2DM according to a mathematical model obtained by regression analysis, for the timely implementation of appropriate preventive measures among T2DM patients.

Materials And Methods: We analyzed 541 medical records of T2DM patients. Read More

J Nucl Med 2021 07 12;62(7):886-895. Epub 2021 Feb 12.

Molecular Imaging and Therapy Service, Memorial Sloan Kettering Cancer Center, New York, New York.

Part 2 of this series of Continuing Education articles on benign thyroid disorders deals with nodular goiter, hypothyroidism, and subacute thyroiditis. Together with Part 1 (which dealt with various forms of hyperthyroidism), this article is intended to provide relevant information for specialists in nuclear medicine dealing with the clinical management of patients with benign thyroid disorders, the primary audience for this series. Goiter, an enlargement of the thyroid gland, is a common endocrine abnormality. Read More

Int J Surg Case Rep 2020 4;77:430-433. Epub 2020 Nov 4.

Singida Regional Referral Hospital, Tanzania; Surgery Department, Tanzania; Radiology Department, Tanzania.

Introduction: Multinodular goiter (MNG) is a clinic pathological entity characterized by an increased volume of the thyroid gland with formation of nodules. Goiter is defined as a thyroid gland weighing over 20-25 g or with a volume of over 19 ml in women and 25 ml in men. In developed countries where iodination of food is common and health services are available and accessible, hardly will you see a goiter of up to 0. Read More

Stem Cell Investig 2020 10;7:18. Epub 2020 Oct 10.

Division of Endocrinology, Department of Medicine, Nassau University Medical Center, East Meadow, NY, USA.

Epidermal inclusion cysts (EIC) are common benign lesions of the skin, ovaries, and testicles. However, their occurrence in thyroid gland is rare. We reported a case in which a 57-year-old male patient with history of nontoxic uninodular goiter presented with dysphonia and dysphagia. Read More

Eur Endocrinol 2020 Oct 6;16(2):131-135. Epub 2020 Oct 6.

Department of Radiology, Hue Central Hospital, Hue, Vietnam.

Colloid goitres are a common, benign lesion of the thyroid gland, that involve a diffuse or nodular pattern. An important feature of colloid goitre is the contained colloid material inside and the comet-tail artefacts, which show up on ultrasound. However, some cases of colloid goitre do not show a comet-tail sign and sometimes these artefacts need to be distinguished from microcalcifications in malignant lesions. Read More

Endocrine 2021 06 3;72(3):735-743. Epub 2020 Oct 3.

Inozemtsev City Clinical Hospital of Moscow Department of Health, Moscow, Russia.

Objective: Cytochrome b5-reductase (CYB5R) and cytochrome P450 reductase (CYPOR) are important for cell metabolism; however, their role in thyroid hormonogenesis and carcinogenesis has not been elucidated yet. The activity of CYB5R correlates with the metastasis in breast cancer, but there are no similar studies for CYB5R and CYPOR for thyroid tumors. The aim of this study was to elucidate the activity of CYB5R and CYPOR changes in benign euthyroid and hyperthyroid neoplasms and in papillary thyroid cancer for their potential application as biomarkers for diagnosis and prognosis prediction of thyroid cancer. Read More

Cureus 2020 Aug 30;12(8):e10140. Epub 2020 Aug 30.

Internal Medicine, Centro Hospitalar do Médio Ave, Vila Nova de Famalicão, PRT.

Alice in Wonderland syndrome (AIWS) is a rare disorder that refers to episodic body image distortions, sometimes associated with altered perception of external space and time. AIWS is mainly associated with viral disease in children as well as migraines and epileptic seizures in adults. Its pathogenesis is still very much unknown and there are not many reported drug-associated cases in medical literature. Read More

Arch Dermatol Res 2021 Jul 23;313(5):339-346. Epub 2020 Jul 23.

School of Medicine, National Yang-Ming University, Taipei, Taiwan.

Alopecia areata (AA) has long been associated with thyroid diseases; however, the temporality of their association remains unclear. This study aimed to investigate the bidirectional association between AA and thyroid diseases. In analysis 1, we included 5929 AA patients and 59,290 matched controls to assess the risk of thyroid diseases. Read More

Endocrine 2021 02 21;71(2):514-519. Epub 2020 Jul 21.

Department of Endocrinology, Metabolism and Internal Diseases, Poznan University of Medical Sciences, 49 Przybyszewskiego Street, 60-355, Poznan, Poland.

Purpose: Thyroid hemiagenesis (THA) is an inborn absence of one thyroid lobe of largely unknown etiopathogenesis, affecting 0.05-0.5% population. Read More

Thyroid 2021 01 19;31(1):23-35. Epub 2020 Aug 19.

Service of Endocrinology, Diabetology and Metabolism, Lausanne University Hospital, Lausanne, Switzerland.

Familial nontoxic multinodular goiter (MNG) is a rare disease. One of the associated genes is Kelch-like ECH-associated protein 1 (), which encodes the main inhibitor of nuclear factor erythroid 2-related transcription factor 2 (Nrf2), a central mediator of antioxidant responses. The association of with familial MNG is based on only two loss-of-function mutations identified in two families, only one of which included proper phenotyping and adequate demonstration of co-segregation of the phenotype and the mutation. Read More

J Cancer Res Clin Oncol 2020 Nov 9;146(11):2989-2994. Epub 2020 Jun 9.

Department of Epidemiology, IQVIA, Unterschweinstiege 2-14, 60549, Frankfurt, Germany.

Background: The goal of this retrospective cohort study was to analyze the association between benign thyroid alteration and thyroid cancer in patients followed in general practices in Germany.

Methods: Patients aged 18-80 who had received an initial diagnosis of thyroid cancer in one of 1261 general practices in Germany between January 2009 and December 2018 were included in this study (index date). These patients were matched (1:1) to non-cancer patients by age, sex, physician and index year. Read More

Pak J Med Sci 2020 May-Jun;36(4):831-835

Dr. Sehrish Altaf, Department of Surgery Ward 25, Jinnah Postgraduate Medical Center, Karachi, Pakistan.

Background And Objective: Surgical managements for these suspicious nontoxic swellings requires open conventional method of thyroidectomy by neck incisions that can result in prominent scars and immediate risk usually hemorrhage. However new technological innovations came into practiced that include video assisted minimal invasive endoscopy by axillo-breast approach that gives very promising results with excellent cosmesis. In this study, we compared conventional open surgery with minimal invasive endoscopic techniques and associate various complaints and complications that were encountered in surgery. Read More

Nucl Med Commun 2020 Aug;41(8):727-732

Endocrinology Division.

Objective: To analyze outcomes of patients with compressive nontoxic multinodular goiter after 131I-iodine 30 mCi treatment without previous use of recombinant human thyroid-stimulating hormone or methimazole.

Methods: We evaluated fixed-dose radioiodine therapy outcomes in patients with nontoxic multinodular goiter who did not accept thyroidectomy as a therapeutic option. Laboratory thyroid function and thyroid volume estimated by ultrasound were assessed before and one year after radioiodine therapy. Read More

J Med Life 2020 Jan-Mar;13(1):21-25

Department of Medical Biology, I. Horbachevsky Ternopil National Medical University, Ternopil, Ukraine.

Immunopathogenesis of inflammatory and dystrophic diseases of the tissues of the oral cavity is characterized by cellular and humoral factors of specific and nonspecific resistance, the functioning of which is determined by the overall somatic state. This study aimed to study the features of protective mechanisms of the oral cavity due to orthodontic pathology, pathology of periodontal tissues, and odontogenic inflammatory process in children with diffuse nontoxic goiter. Eighty children with diffuse nontoxic goiter aged 12-15 years with different dental status were examined. Read More

Endocrinol Diabetes Metab 2020 Apr 26;3(2):e00115. Epub 2020 Feb 26.

University Hospital for Visceral Surgery Medical Campus University of Oldenburg Pius-Hospital Oldenburg Germany.

Objective: Quality of life (QoL) has so far seldom been taken into account by default in decision-making for surgical indication in thyroid surgery. Therefore, we compared pre- and postoperative QoL of patients using the EuroQoL-5D (EQ-5D) questionnaire. The influence of certain socio-economic factors on QoL as a second end-point was considered. Read More

J Endocrinol Invest 2020 Jul 6;43(7):1043-1044. Epub 2020 Mar 6.

Endocrine Unit, Department of Medicine & Surgery, University of Insubria, ASST dei Sette Laghi, Varese, Italy.

Visc Med 2020 Feb 21;36(1):28-33. Epub 2020 Jan 21.

Department of General, Visceral, Cancer and Transplantation Surgery, University of Cologne, Cologne, Germany.

Introduction: Benign nodular goiters are endemic in Germany and diagnostic thyroidectomy is one of the most frequent surgical procedures. Less than 10% result in a malignant finding which is a poor ratio in comparison to other European countries. There is a female preponderance in almost all thyroid pathologies according to the current literature but not much is known concerning gender-specific differences in thyroid nodules. Read More

AACE Clin Case Rep 2019 Sep-Oct;5(5):e326-e329. Epub 2019 Jun 26.

Objective: Clinically apparent thyroid enlargement due to massive amounts of amyloid deposition, known as amyloid goiter, is rare. Endocrinologists should become familiar with this manifestation of systemic amyloidosis, which may be diagnosed by Congo red staining of the specimen obtained by fine-needle aspiration.

Methods: We describe a 70-year-old man who presented with a slowly enlarging goiter. Read More

Invest Ophthalmol Vis Sci 2019 10;60(13):4129-4140

Department of Ophthalmology, Severance Hospital, Institute of Vision Research, Yonsei University College of Medicine, Seoul, Korea.

Purpose: We examined the therapeutic effect of nontoxic concentrations of curcumin, a plant polyphenol extracted from Curcuma longae, in primary cultures of orbital fibroblasts from Graves' orbitopathy (GO).

Methods: The effect of curcumin on interleukin (IL)-1β induced-proinflammatory cytokine production was determined using quantitative real-time PCR, enzyme-linked immunosorbent assay (ELISA), and Western blot analysis. Adipogenic differentiation was identified using Oil-Red O staining, and levels of peroxisome proliferator activator γ (PPARγ) and CCAAT-enhancer-binding proteins (C/EBP) α/β were determined by Western blot analyses. Read More

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 2020 Mar 23;164(1):77-83. Epub 2019 May 23.

Clinic of Endocrinological and General Surgery, Chair of Endocrinology, Medical University of Lodz, Pabianicka 62, 93-513 Lodz, Poland.

Background: The rising incidence of thyroid cancer observed in the last few decades requires an improvement in diagnostic tools and management techniques for patients with thyroid nodules.

Aims: The aim of this study was to assess serum concentrations of IGF-1 and IGF-1R in patients diagnosed with thyroid cancers.

Methods: 36 patients diagnosed with papillary thyroid cancer (PTC), 11 subjects with follicular thyroid cancer (FTC), 9 patients with anaplastic thyroid cancer (ATC) and 19 subjects with multinodular nontoxic goiter (MNG) were enrolled to the study. Read More

Surgery 2019 09 16;166(3):356-361. Epub 2019 May 16.

Department of Endocrinology and Metabolism, Ankara Yıldırım Beyazıt University Faculty of Medicine, Ankara, Turkey.

Background: The suppressive effect of the increase in thyroid hormone in patients with toxic nodular goiter is thought to protect the extranodular thyroid tissue from thyroid malignancy. In this study, we aimed to evaluate the prevalence and features of thyroid cancer in patients with toxic nodular goiter who underwent thyroidectomy.

Methods: Medical data of patients who had solitary toxic or nontoxic nodules and underwent total thyroidectomy were reviewed retrospectively. Read More

Surgery 2019 11 13;166(5):954-955. Epub 2019 May 13.

Department of Visceral and Endocrine Surgery, CHU Poitiers, Poitiers, France. Electronic address:

Surgery 2019 11 28;166(5):954. Epub 2019 Mar 28.

Department of General Surgery, All India Institute of Medical Sciences, Patna, India. Electronic address:

J ASEAN Fed Endocr Soc 2019 10;34(2):153-157. Epub 2019 Nov 10.

Division of Neurology, Department of Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.

Introduction: Both myasthenia gravis (MG) and autoimmune thyroid diseases (AITDs) are autoimmune diseases. Graves'disease (GD) is the most common AITD reported to be associated with MG. Currently, there is limited data on prevalence and clinical features/outcomes of MG in various thyroid diseases in a large database report. Read More

HNO 2018 Dec;66(12):922-928

Klinik für Hals-Nasen-Ohrenheilkunde, Kopf- und Halschirurgie, Städtisches Klinikum Solingen, Solingen, Deutschland.

Objective: The aim of this study was to investigate thyroid disorder diagnoses in otorhinolaryngologic (ENT) practices in Germany compared to general (GP) practices using data from a representative Germany-wide practice database.

Methods: The database was retrospectively searched for diagnoses of thyroid disorders made in ENT and GP practices between January 2008 and December 2016. Data were collected on the most common three-character disease classes (categories) from the "Disorders of thyroid gland" (E00-E07) group as well as the "Benign neoplasm of thyroid gland" (D34) and "Malignant neoplasm of thyroid gland" (C73) categories. Read More