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    Benign Thyroid Diseases and Risk of Thyroid Cancer: A Nationwide Cohort Study.
    J Clin Endocrinol Metab 2018 Mar 23. Epub 2018 Mar 23.
    Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark.
    Context: Thyroid nodules, adenomas, and goiter have consistently been associated with thyroid cancer risk. Few studies have assessed whether thyroid dysfunction and thyroid autoimmunity influence this risk.

    Objective: To examine thyroid cancer risk following diagnoses of a wide range of benign thyroid conditions. Read More
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    Alteration in the serum concentrations of FGF19, FGFR4 and βKlotho in patients with thyroid cancer.
    Cytokine 2018 May 10;105:32-36. Epub 2018 Feb 10.
    Department of Immunoendocrinology, Chair of Endocrinology, Medical University of Lodz, Sterlinga 3, 91-425 Lodz, Poland.
    Introduction: βKlotho (βKL) is known to act as co-receptor for fibroblast growth factor receptor 4 (FGFR4) which is the main cognate receptor for fibroblast growth factor 19 (FGF19). Dysregulation of this FGF19/FGFR4/βKL signaling axis has been implicated in the pathogenesis of several cancers. However, its role in the pathogenesis of thyroid cancer has not been determined. Read More
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    Cancer Frequency in Retrosternal Goiter.
    Am Surg 2017 Dec;83(12):1390-1393
    Retrosternal goiter prevalence is 5 to 40 per cent according to classifications in goiter series. Goiters with mediastinal extension were reported to be related with higher cancer rates. In our study, we aimed to investigate whether cancer incidence increased in retrosternal goiters compared with the cervical ones. Read More
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    The association between irisin and muscle metabolism in different thyroid disorders.
    Clin Endocrinol (Oxf) 2018 Mar 20;88(3):460-467. Epub 2017 Dec 20.
    Department of Endocrinology, Metabolism and Internal Medicine, Poznań University of Medical Sciences, Poznań, Poland.
    Background: Irisin is a new adipo-myokine, encoded by the FNDC5 gene. Currently, there is a discussion regarding the relation between thyroid function and irisin concentration. This prospective study assesses the influence of thyrometabolic changes on serum irisin concentration in association with altered muscle metabolism. Read More
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    Quality of life after thyroidectomy in patients with nontoxic nodular goiter: A prospective cohort study.
    Head Neck 2017 Nov 4;39(11):2232-2240. Epub 2017 Sep 4.
    Department of ORL Head & Neck Surgery, Odense University Hospital, Odense, Denmark.
    Background: Using the thoroughly validated Thyroid-Related Quality-of-Life Patient-Reported Outcome (ThyPRO) questionnaire, the purpose of this study was to investigate changes in disease-specific quality of life (QOL) after surgical treatment in patients with benign nontoxic multinodular goiters.

    Method: Patients with goiters scheduled for thyroid surgery (n = 106) and individuals from the general population (n = 739) were studied. The ThyPRO data before, 3 months, and 6 months after surgery were compared with normative scores from the general population using a linear mixed model and t tests. Read More
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    The Concomitant Association of Thyroid Disorders and Myasthenia Gravis.
    Transl Neurosci 2017 30;8:27-30. Epub 2017 Apr 30.
    Division of Endocrinology and Metabolism, Department of Internal Medicine, Taipei Medical University Hospital, Taipei, Taiwan.
    Background: Some of the thyroid disorders (TD) and Myasthenia gravis (MG) are autoimmune related disease. The purpose of the study to evaluate the relationship of MG with all morphological and functional thyroid disorders.

    Methods: We constructed a population-based cohort study during the period from January 2000-December 2002 by using reimbursement data from the Bureau National Health Insurance (NHI) system in Taiwan. Read More
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    Increased Cardiovascular Mortality and Morbidity in Patients Treated for Toxic Nodular Goiter Compared to Graves' Disease and Nontoxic Goiter.
    Thyroid 2017 Jul 5;27(7):878-885. Epub 2017 Jun 5.
    6 Department of Clinical Research and Education, Sodersjukhuset, Karolinska Institutet , Stockholm, Sweden .
    Background: Previous research has suggested an increased risk of death and cardiovascular disease in patients treated for hyperthyroidism. However, studies on this subject are heterogeneous, often based on old data, or have not considered the impact that treatment for hyperthyroidism might have on cardiovascular risk. It is also unclear whether long-term prognosis differs between Graves' disease and toxic nodular goiter. Read More
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    Neglected nontoxic multinodular goiter presented as a large neck mass.
    Clin Case Rep 2017 Mar 20;5(3):357-358. Epub 2016 Dec 20.
    Department of Anatomy-Histology-Embryology University of Ioannina School of Medicine Ioannina Greece.
    Large multinodular goiters, obvious to the naked eye, are rarely confronted by clinicians nowadays; yet they do have a place in the differential diagnosis of the neck masses. Due to the fact that 80% of the neck masses in adults are related to malignancy, the later should be ruled out. Read More
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    Elevated Concentrations of SERPINE2/Protease Nexin-1 and Secretory Leukocyte Protease Inhibitor in the Serum of Patients with Papillary Thyroid Cancer.
    Dis Markers 2017 31;2017:4962137. Epub 2017 Jan 31.
    Department of Immunoendocrinology, Chair of Endocrinology, Medical University of Lodz, Sterlinga 3, 91-425 Lodz, Poland.
    . SERPINE2 and secretory leukocyte protease inhibitor (SLPI) are proteins with anticoagulant properties which could promote solid tumor growth. However, their role in the pathogenesis of thyroid cancer has not been determined. Read More
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    Deep Sequencing Reveals Spatially Distributed Distinct Hot Spot Mutations in DICER1-Related Multinodular Goiter.
    J Clin Endocrinol Metab 2016 Oct 26;101(10):3637-3645. Epub 2016 Jul 26.
    Departments of Human Genetics (L.d.K., M.K.W., W.D.F.), Pathology (I.B.), Oncology (W.D.F.), McGill University; Department of Medical Genetics, Lady Davis Institute, Segal Cancer Centre, Jewish General Hospital (L.d.K., M.K.W., N.S., W.D.F.); Research Institute of the McGill University Health Centre (L.d.K., W.D.F.); McGill University and Genome Québec Innovation Centre (T.R., P.B., J.R.), Montréal, Québec, Canada; and (J.R.P.), Minneapolis, Minnesota, USA.
    Context: Nontoxic multinodular goiter (MNG) occurs frequently, but its genetic etiology is not well established. Familial MNG and MNG occurring with ovarian Sertoli-Leydig cell tumor are associated with germline DICER1 mutations. We recently identified second somatic DICER1 ribonuclease (RNase) IIIb mutations in two MNGs. Read More
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    Intrathoracic toxic thyroid nodule causing hyperthyroidism with a multinodular normal functional cervical thyroid gland.
    Indian J Nucl Med 2016 Jul-Sep;31(3):229-31
    Department of Nuclear Medicine, Medical Faculty, Trakya University, Edirne, Turkey.
    Radionuclide scintigraphy with I-131 and Tc-99m pertechnetate ((99)mTc04) has been widely used in detecting toxic nodules. Intrathoracic goiter usually presents as an anterior mediastinal mass. Mostly the connection between intrathoracic mass and the cervical thyroid gland is clearly and easily identified occurring as a result of inferior extension of thyroid tissue in the neck, which is called as secondary intrathoracic goiter. Read More
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    Total Thyroidectomy versus Bilateral Subtotal Thyroidectomy for Bilateral Multinodular Nontoxic Goiter: A Meta-Analysis.
    ORL J Otorhinolaryngol Relat Spec 2016 3;78(3):167-75. Epub 2016 Jun 3.
    Department of Surgical Oncology, Ningbo No. 2 Hospital, Ningbo, China.
    Aim: The aim of this meta-analysis is to assess and validate the feasibility and safety of total thyroidectomy (TT) when compared to bilateral subtotal thyroidectomy (BST) for bilateral multinodular nontoxic goiter (BMNG).

    Materials And Methods: PubMed, Web of Knowledge, and Ovid's database were searched for studies published in English language between January 1990 and December 2014. A meta-analysis was performed to compare the complications and recurrences of TT versus BST. Read More
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    Radioiodine Therapy Does Not Change the Atherosclerotic Burden of the Carotid Arteries.
    Thyroid 2016 07 20;26(7):965-71. Epub 2016 May 20.
    4 Department of Clinical Physiology and Nuclear Medicine, University Hospital of Herlev , Herlev, Denmark .
    Background And Aim: Atherosclerosis evolves or accelerates when arteries are exposed to ionizing radiation, both early and late after exposure. Radioiodine therapy of benign thyroid disease exposes the carotid arteries to 4-50 Gy, and may thereby increase the risk of atherosclerosis. Increased risk of cerebrovascular events has been reported after radioiodine therapy. Read More
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    The Rate and Clinical Significance of Incidental Thyroid Uptake as Detected by Gallium-68 DOTATATE Positron Emission Tomography/Computed Tomography.
    Thyroid 2016 06 6;26(6):831-5. Epub 2016 May 6.
    1 Endocrine Oncology Branch, National Cancer Institute, National Institutes of Health , Bethesda, Maryland.
    Background: Gallium-68 (Ga-68) DOTATATE is a radiolabeled peptide-imaging modality that targets the somatostatin receptor (SSTR), especially subtype 2 (SSTR2). Benign and malignant thyroid tumors have been observed to express SSTR. The aim of this study was to evaluate the frequency and clinical significance of incidental atypical thyroid uptake as detected by Ga-68 DOTATATE positron emission tomography/computed tomography (PET/CT). Read More
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    Graves' disease in a mediastinal mass presenting after total thyroidectomy for nontoxic multinodular goiter: a case report.
    J Med Case Rep 2016 Mar 31;10:70. Epub 2016 Mar 31.
    Serviço de Endocrinologia, Diabetes e Metabolismo, Centro Hospitalar de São João, Alameda Professor Hernâni Monteiro, 4202-451, Porto, Portugal.
    Background: Thyrotoxicosis after total thyroidectomy is mostly iatrogenic. Rarely, a hyperfunctional thyroid remnant or ectopic tissue may be the cause. There are few cases of Graves' disease arising from thyroid tissue located in the mediastinum and none in which Graves' disease was diagnosed only after surgery. Read More
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    Single, very low dose (0.03 mg) of recombinant human thyrotropin (rhTSH) effectively increases radioiodine uptake in the I-131 treatment of large nontoxic multinodular goiter.
    Nucl Med Rev Cent East Eur 2016 ;19(1):3-11
    Nuclear Medicine Department, Medical University of Bialystok, Poland.
    Background: Radioiodine therapy (RIT) in patients with large nontoxic multinodular goiter (MNG) recently becomes more common method in comparison to surgery (especially in elderly patients and with contraindications because of severe chronic diseases other systems). Repeatedly low thyroid radioactive iodine uptake (RAIU) decreases effectiveness of RIT or makes it impossible. The recombinant human thyrotropin can increase RAIU and improve the results of RIT. Read More
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    [The problem of iodine deficiency and its solution in the republic of Belarus].
    Gig Sanit 2016 ;95(5):417-21
    The problem of iodine deficiency is relevant to the Republic of Belarus. It’s confirmed by virtually commonly found geophysical iodine deficiency in soils and waters. Data on iodine deficiency initiated the development of a state strategy for the elimination of iodine deficiency in the population. Read More
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    A Prospective Study on Cardiovascular Dysfunction in Patients with Hyperthyroidism and Its Reversal After Surgical Cure.
    World J Surg 2016 Mar;40(3):622-8
    Department of Endocrine Surgery, Madras Medical College, Chennai, India.
    Background: Cardiovascular dysfunction (CVD) is a major cause of mortality and morbidity in hyperthyroidism. CVD and its reversibility after total thyroidectomy (TT) are not adequately addressed. This prospective case-control study evaluates the effect of hyperthyroidism on myocardium and its reversibility after TT. Read More
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    PRDM1 expression via human parvovirus B19 infection plays a role in the pathogenesis of Hashimoto thyroiditis.
    Hum Pathol 2015 Dec 10;46(12):1913-21. Epub 2015 Sep 10.
    Department of Pathology, State Key Laboratory of Cancer Biology, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, PR China. Electronic address:
    Ectopic lymphoid follicle infiltration is a key event in Hashimoto thyroiditis (HT). Positive regulatory domain zinc finger protein 1 (PRDM1), which is induced by antigen stimulation, can regulate all lymphocyte lineages. Several groups independently demonstrated that human parvovirus B19 (PVB19) is closely associated with HT. Read More
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    The feasibility of low-dose oral lithium therapy and its effect on thyroidal radioiodine uptake, retention, and hormonal parameters in various subcategories of hyperthyroid patients: a pilot study.
    Nucl Med Commun 2016 Jan;37(1):74-8
    Radiation Medicine Centre, Bhabha Atomic Research Centre, Tata Memorial Hospital Annexe, Mumbai, Maharashtra, India.
    Background: Radioactive iodine (I) (RAI) is used widely for the treatment of hyperthyroidism either as a first-line treatment or following relapse after antithyroid drug treatment. Intrathyroidal retention of RAI is considered an important determinant of its effectiveness, which is believed to be prolonged by lithium.

    Aims And Objectives: To study the impact of low-dose oral lithium therapy on RAI uptake and retention parameters in different subgroups of hyperthyroidism patients, and thus explore its potential role in enhancing the therapeutic efficacy of RAI in these groups of patients. Read More
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    Etiopathology, clinical features, and treatment of diffuse and multinodular nontoxic goiters.
    J Endocrinol Invest 2016 Apr 21;39(4):357-73. Epub 2015 Sep 21.
    Thyroid Unit, Division of Endocrinology and Metabolism, Hospital das Clínicas, University of São Paulo Medical School, Av. Dr. Enéas de Carvalho Aguiar, 155 - 8th floor, bl 3, PAMB, São Paulo, 05403-900, Brazil.
    Goiter, an enlargement of the thyroid gland, is a common problem in clinical practice associated with iodine deficiency, increase in serum thyroid-stimulating hormone (TSH) level, natural goitrogens, smoking, and lack of selenium and iron. Evidence suggests that heredity also has an important role in the etiology of goiter. The current classification divides goiter into diffuse and nodular, which may be further subdivided into toxic (associated with symptoms of hyperthyroidism, suppressed TSH or both), or nontoxic (associated with a normal TSH level). Read More
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    Assessing perioperative body weight changes in patients thyroidectomized for a benign nontoxic nodular goitre.
    Clin Endocrinol (Oxf) 2016 Jun 19;84(6):882-8. Epub 2015 Oct 19.
    School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.
    Background: Following thyroidectomy, patients often complain of weight gain. Our study aimed to evaluate the extent of weight change in patients thyroidectomized for a nontoxic benign goitre after adjusting for patient demographics and pre-operative weight changes.

    Methods: Three different patient groups were studied. Read More
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    Postoperative Acute Respiratory Failure In Patients Treated Surgically For Goiters.
    Pol Przegl Chir 2015 Jul;87(7):331-5
    Unlabelled: The aim of the study was to present a clinical picture, treatment and prognosis regarding patients who developed acute respiratory failure (ARF) while treated surgically for a goiter.

    Material And Methods: A total of 3810 patients were treated for goiters between 2008 to 2013. Symptoms of postoperative ARF were recognized in 39 (1%) patients. Read More
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    Large multinodular goiter--outpatient radioiodine treatment.
    Endokrynol Pol 2015 ;66(4):301-7
    Department of Endocrinology and Internal Medicine, Medical University of Gdansk, Gdansk, Poland.
    Introduction: 131-I treatment of nodular, especially nontoxic, goitre is still reserved mainly for elderly patients, whose numerous concomitant diseases disqualify them from surgery. Therapy often involves isolation and is available only in selected centres, which may be located far from some patients' places of residence, which is inconvenient for elderly people. The aim of the study was to assess the effectiveness of outpatient fractionated 131-I treatment of patients with large nodular goitres, as well as to evaluate complications and the factors affecting treatment results. Read More
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    Bone Indices in Thyroidectomized Patients on Long-Term Substitution Therapy with Levothyroxine Assessed by DXA and HR-pQCT.
    J Thyroid Res 2015 13;2015:796871. Epub 2015 Jul 13.
    Department of Endocrinology and Internal Medicine, THG, Aarhus University Hospital, 8000 Aarhus C, Denmark.
    Background. Studies on bone effects of long-term substitution therapy with levothyroxine (LT4) have shown discrepant results. Previous studies have, however, not evaluated volumetric bone mineral densities (vBMD), bone structure, and strength using high resolution peripheral quantitative computed tomography (HR-pQCT) and finite element analysis (FEA). Read More
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    B Cell Activating Factor (BAFF) and BAFF Receptor Expression in Autoimmune and Nonautoimmune Thyroid Diseases.
    Thyroid 2015 Sep 13;25(9):1043-9. Epub 2015 Aug 13.
    1 Graves' Orbitopathy Center , Endocrinology Unit, Department of Clinical Sciences and Community Health, Ospedale Maggiore Policlinico of Milan and Università degli Studi di Milano , Milan, Italy .
    Background: The B cell activating factor (BAFF) is a member of the tumor necrosis factor family, which controls the survival/proliferation of B cells and is involved in the pathogenesis of a number of autoimmune diseases. The objective of the present study was to investigate the expression of BAFF and BAFF receptor (BAFF-R) in the thyroid tissue of patients affected with autoimmune thyroid disorders (AITD) or multinodular goiter (MNG) compared with those with normal thyroids.

    Methods: Immunohistochemistry was performed using a panel of antibodies against BAFF, BAFF-R, CD3, CD4, CD8, CD20, CD34, CD79a, CD1a, CD68, and CD163 on the thyroid sections of 27 patients affected with Graves' disease (GD), 23 with Hashimoto's thyroiditis (HT), 16 with nontoxic nodular goiter (NTG), and 15 with toxic nodular goiter (TG), submitted to total thyroidectomy between 2000 and 2011. Read More
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    High Frequency of Thyroid Disorders in Patients Presenting With Neutropenia to an Outpatient Hematology Clinic STROBE-Compliant Article.
    Medicine (Baltimore) 2015 Jun;94(23):e886
    From the Division of Endocrinology, Metabolism and Diabetes, First Department of Pediatrics, National and Kapodistrian University of Athens, University of Athens Medical School, "Aghia Sophia" Children's Hospital, (EMK); Hematology Clinic, Athens Medical Center, Psychiko Branch, Athens (XY, GAP); Department of Hematology, University of Crete School of Medicine, Heraklion, Crete (CP, KP, CK, IM, HK, SM, HAP); Department of Hematology and BMT, National and Kapodistrian University of Athens, Laikon General Hospital (TPV, MKA); First Department of Internal Medicine, National and Kapodistrian University of Athens, Laikon General Hospital (GV); and Third Department of Internal Medicine, Medical School, University of Athens, Sotiria General Hospital, Athens, Greece (ED-K).
    Granulopoiesis abnormalities have been described in association with thyroid disorders (TD). However, data regarding systematic evaluation of adult neutropenia and concurrent or prior TD are scarce. To investigate the frequency of TD among patients presenting with neutropenia, and the immunophenotypic and immunologic profile of neutropenic patients with concomitant thyroidopathy. Read More
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    Is Preoperative Vitamin D Deficiency a Risk Factor for Postoperative Symptomatic Hypocalcemia in Thyroid Cancer Patients Undergoing Total Thyroidectomy Plus Central Compartment Neck Dissection?
    Thyroid 2015 Aug 17;25(8):911-8. Epub 2015 Jun 17.
    1 Department of Surgery, Institute of Endocrine Research, Yonsei University Health System , Seoul, Korea.
    Background: Although some studies have reported that preoperative vitamin D deficiency (VDD) is a risk factor for hypocalcemia after total thyroidectomy (TT) in patients with nontoxic multinodular goiter or Graves' disease, the association between VDD and postoperative hypocalcemia in thyroid cancer patients undergoing TT plus central compartment neck dissection (CCND) remains unclear. This study evaluated whether preoperative VDD was associated with postoperative symptomatic hypocalcemia.

    Materials And Methods: Data were collected prospectively between September 2012 and May 2013. Read More
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    [Distribution iodine deficiency diseases in coastal areas depending on geochemical conditions].
    Gig Sanit 2014 Sep-Oct(5):97-104
    In the Primorsky Krai there was performed a population ecological and hygienic analysis of the relationship between the content of chemical elements in the soil and thyroid morbidity in the population of the region. The assessment of the prevalence of iodine deficiency and iodine deficiency diseases was carried out on the basis of the impact of the priority environmental toxic (strontium, nickel, cadmium, lead, arsenic, tin) and essential (nickel, iron, germanium, molybdenum, zinc, selenium) trace elements on the level of iodine deficiency diseases. The level of thyroid pathology in the territory of Primorye was established to be the highest one in areas characterized by the severe iodine deficiency (Northwest geochemical zones), where the structure of thyroid diseases is presented mainly by diffuse nontoxic goiter. Read More
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    Papillary Carcinoma Occurrence in a Thyroglossal Duct Cyst with Synchronous Papillary Thyroid Carcinoma without Cervical Lymph Node Metastasis: Two-Cases Report.
    Case Rep Surg 2015 15;2015:872054. Epub 2015 Feb 15.
    Surgical Oncology Division, Department of Surgery, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Diponegoro Street 71, Jakarta 10430, Indonesia.
    Background. We present two rare cases of papillary carcinomas which appeared in thyroglossal duct cysts. These cases highlight that thyroglossal duct cyst can serve as malignancy of thyroid gland. Read More
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    Elevated Serum Thyroglobulin and Low Iodine Intake Are Associated with Nontoxic Nodular Goiter among Adults Living near the Eastern Mediterranean Coast.
    J Thyroid Res 2014 14;2014:913672. Epub 2014 Dec 14.
    Nutrition and Brain Health Laboratory, School of Nutritional Sciences, Institute of Biochemistry, Food Science and Nutrition, Robert H. Smith Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem, P.O. Box 12, 76100 Rehovot, Israel.
    Background. Information about iodine intake is crucial for preventing thyroid diseases. Inadequate iodine intake can lead to thyroid diseases, including nontoxic nodular goiter (NNG). Read More
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    Quality of life in patients with benign nontoxic goiter: impact of disease and treatment response, and comparison with the general population.
    Thyroid 2015 Mar 10;25(3):284-91. Epub 2015 Feb 10.
    1 Department of Medical Endocrinology, Copenhagen University Hospital Rigshospitalet , Copenhagen, Denmark .
    Background: While health-related quality of life (HRQoL) issues often prompt treatment of benign nontoxic goiter (NTG), few clinical studies have systematically assessed HRQoL in patients with this condition. The purpose of the present study was to evaluate thyroid-related and generic HRQoL in patients with benign NTG, as compared to the general population, before and six months after treatment.

    Methods: Thyroid-related and generic HRQoL were assessed with Thyroid Patient-Reported Outcome (ThyPRO) and Medical Outcomes Study 36-item Short Form (SF-36), respectively. Read More
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    Assessment of cyclooxygenase-1 and 2 gene expression levels in chronic autoimmune thyroiditis, papillary thyroid carcinoma and nontoxic nodular goitre.
    Thyroid Res 2014 17;7(1):10. Epub 2014 Dec 17.
    Department of Endocrinology and Metabolic Diseases, Medical University of Lodz, Rzgowska St. No. 281/289, 93-338 Lodz, Poland.
    Introduction: The cyclooxygenases are a group of enzymes catalyzing the formation of prostaglandins from arachidonic acid. Cyclooxygenase-1 (COX-1) is a constitutive form, thought to be a "housekeeping gene", with constant levels of expression in most tissues. COX-1 expression in the thyroid gland, except for medullary thyroid carcinoma, has not been a subject of much interest. Read More
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    [Imbalance of microelements and vitamins in adolescents with diffuse nontoxic goiter and biliary dyskinesia].
    Lik Sprava 2014 Nov(11):138-42
    The purpose of the present work was to study the level of microelements and vitamins in adolescents with diffuse nontoxic goiter. It has been shown that comorbid biliary dyskinesia leads to significant dysregulation of vitamin and mineral metabolism: the level of essential elements was decreased and the level of toxic elements was increased. Comorbid biliary dyskinesia in adolescents with diffuse nontoxic goiter was accompanied by a disbalance of vitamins. Read More
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    Recombinant human thyrotropin before (131)I therapy in patients with nodular goitre: a meta-analysis of randomized controlled trials.
    Clin Endocrinol (Oxf) 2015 Nov 29;83(5):702-10. Epub 2014 Dec 29.
    Division of Endocrinology & Metabolism, Department of Internal Medicine, Taipei Medical University - Shuang Ho Hospital, New Taipei City, Taiwan.
    Background: Recombinant human thyrotropin (rhTSH) can be used to enhance radioiodine therapy for shrinking multinodular goitre. The aim of this meta-analysis was to compare the effectiveness of rhTSH pretreatment and radioiodine therapy with that of radioiodine alone for treating benign nodular goitre.

    Methods: The PubMed, EMBASE, Cochrane Library, Scopus and ClinicalTrials. Read More
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    US not bright but right method of thyroid volume estimation even in large and substernal extended goitres. Comparison of US and three methods of CT thyroid evaluation – prospective study.
    Clin Endocrinol (Oxf) 2015 Sep 27;83(3):412-9. Epub 2014 Nov 27.
    Department of Endocrinology and Internal Medicine, Medical University of Gdansk, Gdansk, Poland.
    Background: Ultrasound is nowadays a method of choice for thyroid volume assessment. However, its disadvantage is some inaccuracy, which is said to be higher in huge, especially substernally extended goitres.

    Aims: The aim of the study was to compare the US and CT thyroid volumetric measurements: multi-observers (CT MO) and one-observer (CT OO) to CT planimetry results (CT Pl) in patients with large goitres. Read More
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    Frequent silencing of RASSF1A via promoter methylation in follicular thyroid hyperplasia: a potential early epigenetic susceptibility event in thyroid carcinogenesis.
    JAMA Surg 2014 Nov;149(11):1146-52
    Yale Endocrine Neoplasia Laboratory, Department of Surgery, Yale University School of Medicine, New Haven, Connecticut.
    Importance: Follicular thyroid hyperplasia (FTH) refers to enlargement of the thyroid gland due to cellular hyperplasia. It is frequently encountered in clinical practice in nontoxic uninodular or multinodular goiter. The genetic and epigenetic events associated with the origin and malignant potential of FTH are poorly understood. Read More
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    Effect of tanshinone IIA in an in vitro model of Graves' orbitopathy.
    Invest Ophthalmol Vis Sci 2014 Aug 26;55(9):5900-10. Epub 2014 Aug 26.
    Department of Ophthalmology, Institute of Vision Research, Yonsei University College of Medicine, Seoul, Korea.
    Purpose: We investigated the therapeutic effect of nontoxic concentrations of tanshinone IIA (TanIIA) from Salvia miltiorrhiza in primary cultures of orbital fibroblasts from Graves' orbitopathy (GO).

    Methods: The effect of TanIIA on IL-1β-induced proinflammatory cytokine (IL-6, IL-8, MCP-1) expression was determined by real-time PCR. Antioxidant activity was investigated by measuring intracellular reactive oxygen species (ROS) generation stimulated by cigarette smoke extract (CSE) and heme oxygenase-1 (HO-1) expression. Read More
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    Thyrotoxicosis does not protect against incidental papillary thyroid cancer.
    Surgery 2014 Nov 21;156(5):1153-6. Epub 2014 Aug 21.
    Endocrine Surgery Unit, The Alfred Hospital, Melbourne, Australia. Electronic address:
    Background: Thyroid cancer is the 10th most commonly diagnosed cancer in Australia, and many studies have linked thyroid-stimulating hormone (TSH) and papillary thyroid cancer (PTC). Low TSH is thought to be protective against thyroid cancer. Our aim was to evaluate the relationship between thyrotoxicosis, in particular Graves' disease, and the incidence of incidental PTC. Read More
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    The thyroid-related quality of life measure ThyPRO has good responsiveness and ability to detect relevant treatment effects.
    J Clin Endocrinol Metab 2014 Oct 8;99(10):3708-17. Epub 2014 Jul 8.
    Department of Endocrinology (T.W., P.C., Å.K.R., U.F.-R.), Copenhagen University Hospital Rigshospitalet, DK-2100 Copenhagen, Denmark; Department of Endocrinology and Metabolism (L.H., S.J.B.), Odense University Hospital, DK-5000 Odense, Denmark; QualityMetric (J.B.B.), Lincoln, Rhode Island 02865; Department of Public Health (M.G., J.B.B.), University of Copenhagen, DK-1353 Copenhagen, Denmark; National Research Institute for the Working Environment (J.B.B.), DK-2200 Copenhagen, Denmark; and Department of Palliative Medicine (M.G.), Bispebjerg Hospital, DK-2400 Copenhagen, Denmark.
    Background And Purpose: Patient-reported outcomes have become important endpoints in comparative effectiveness research and in patient-centered health care. Valid patient-reported outcome measures detect and respond to clinically relevant changes. The purpose of this study was to evaluate responsiveness of the thyroid-related quality of life (QoL) instrument ThyPRO in patients undergoing relevant clinical treatments for benign thyroid diseases and to compare it with responsiveness of the generic SF-36 Health Survey. Read More
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    Fine-needle aspiration cytology of type A thymoma with adenoid cystic pattern: a case report with emphasis on peculiar hyaline globules in cytologic smear.
    Diagn Cytopathol 2015 Mar 25;43(3):247-50. Epub 2014 Jun 25.
    Department of Pathology and Laboratory Medicine, Taipei Veterans General Hospital, 11217, Taipei, Taiwan, Republic of China.
    Here we report a case of type A thymoma with adenoid cystic pattern, which extended to the lower anterior neck and clinically mimicked a nontoxic thyroid goiter. The cytologic smears of fine-needle aspiration showed cohesive fragments of short spindle cells with finely granular chromatin and inconspicuous nucleoli. Scant interspersed lymphocytes were present. Read More
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    Increased risk of long-term sickness absence, lower rate of return to work, and higher risk of unemployment and disability pensioning for thyroid patients: a Danish register-based cohort study.
    J Clin Endocrinol Metab 2014 Sep 17;99(9):3184-92. Epub 2014 Jun 17.
    The National Research Centre for the Working Environment (M.A.N., J.P., J.B.B.), DK-2100 Copenhagen, Denmark; Department of Public Health (M.A.N., J.B.B.), Section of Social Medicine, University of Copenhagen, Copenhagen DK-1014, Denmark; Department of Medical Endocrinology (T.W., A.K.R., U.F.-R), Copenhagen University Hospital (Rigshospitalet), Copenhagen DK-2100, Denmark; Department of Endocrinology and Metabolism (S.J.B., L.H.), Odense University Hospital, Odense DK-5000, Denmark; and QualityMetric (an Optum company) (J.B.B.), Lincoln, Rhode Island 02865.
    Context: Little is known about how thyroid diseases affect work ability.

    Objective: The objective of this study was to evaluate the risk of work disability for patients with thyroid disease compared with the general population.

    Design, Setting, And Participants: In a longitudinal register study, outpatients (n = 862) with nontoxic goiter, hyperthyroidism, Graves' orbitopathy (GO), autoimmune hypothyroidism, or other thyroid diseases and their matched controls (n = 7043) were observed in the years 1994-2011 in Danish national registers of social benefits, health, and work characteristics. Read More
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    Body weight changes in a large cohort of patients subjected to thyroidectomy for a wide spectrum of thyroid diseases.
    Endocr Pract 2014 Nov;20(11):1151-8
    Unit of Internal Medicine and Endocrinology, Fondazione Salvatore Maugeri I. R. C. C. S., Chair of Endocrinology, University of Pavia, Pavia, Italy.
    Objective: Patients undergoing thyroidectomy often complain of weight gain. The aim of this study was to longitudinally evaluate body-weight changes in patients thyroidectomized for euthyroid and hyperthyroid conditions in order to identify predictive factors.

    Methods: Anthropometric data and thyroid function parameters were retrospectively reviewed for 267 thyroidectomized patients before and 40 to 60 days and 9 months after surgery. Read More
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    Decreased birth weight, length, and head circumference in children born by women years after treatment for hyperthyroidism.
    J Clin Endocrinol Metab 2014 Sep 30;99(9):3217-23. Epub 2014 May 30.
    Division of Endocrinology (H.O., O.Tö.), Department of Internal Medicine, Södersjukhuset, 11883, Stockholm, Sweden; Institution of Clinical Research and Education (O.Tö.), Department of Medical Epidemiology and Biostatistics (L.Y., A.N.I., P.H., S.L.), and Institution of Molecular Medicine and Surgery (M.A.-N., G.W.), Karolinska Institutet, 17177, Stockholm, Sweden; Department of Oncology (O.Tu.), Karolinska University Hospital, 171 76 Solna, Sweden; and Department of Research and Development (S.L.), Region Halland, 301 80 Halmstad, Sweden.
    Context: Whether hyperthyroidism influences the birth characteristics of children born several years after treatment is unknown.

    Objective: The objective of the study was to compare birth characteristics in singleton newborns delivered by women previously treated for Graves' disease (GD), toxic nodular goiter (TNG), or nontoxic goiter (NTG).

    Design: This was a nested case-control design within a national cohort registry study from 1950 through 2006. Read More
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    Micronucleus frequency among Iraqi thyroid disorder patients.
    Comp Clin Path 2014 28;23:683-688. Epub 2012 Dec 28.
    Genetic Engineering and Biotechnology Institute, Baghdad, Iraq.
    Micronucleus (MN) assay has been extensively used in detection of DNA damage, instability in cancer, and genetic disorders. In the current study, MN, binucleated cells, and nuclear division index (NDI) were investigated in Iraqi patients with thyroid disorders. The results indicated significantly ( < 0. Read More
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    A novel DICER1 mutation identified in a female with ovarian Sertoli-Leydig cell tumor and multinodular goiter: a case report.
    J Med Case Rep 2014 Apr 3;8:112. Epub 2014 Apr 3.
    Center for Genomic Medicine, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
    Introduction: Germ-line mutations in the micro-ribonucleic acid processing gene DICER1 have been shown to predispose to a subset of benign tumors susceptible to malignant transformation, including ovarian Sertoli-Leydig cell tumor, nontoxic multinodular goiter, multilocular cystic nephroma and pleuropulmonary blastoma, which can occur in children and young adults. This may be due to reduced Dcr-1 homolog expression in carriers of germline mutations, which causes impairment of micro-ribonucleic acid processing and deregulates the growth and differentiation of target cells, leading to an increased risk of tumorigenesis. Many carriers of germ-line DICER1 mutations remain unaffected, but development of tumors within carriers is associated with varying prognoses. Read More
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