Khirurgiia (Mosk) 2017 (8):13-17

Pavlov Ryazan State Medical University, Ryazan, Russia.

Aim: To analyze long-term outcomes of Graves' disease management.

Material And Methods: There were 428 patients for the periods 2000-2004 and 2005-2010. Patients were called for examination and thyroid status control. Read More

Transl Neurosci 2017 30;8:27-30. Epub 2017 Apr 30.

Division of Endocrinology and Metabolism, Department of Internal Medicine, Taipei Medical University Hospital, Taipei, Taiwan.

Background: Some of the thyroid disorders (TD) and Myasthenia gravis (MG) are autoimmune related disease. The purpose of the study to evaluate the relationship of MG with all morphological and functional thyroid disorders.

Methods: We constructed a population-based cohort study during the period from January 2000-December 2002 by using reimbursement data from the Bureau National Health Insurance (NHI) system in Taiwan. Read More

Oxf Med Case Reports 2016 Nov 4;2016(11):omw082. Epub 2016 Nov 4.

Consultant Medical Oncologist, University Hospital Limerick , Limerick , Ireland.

Thyrotoxicosis is most commonly caused by Graves' disease, toxic multinodular goitre, a functioning thyroid adenoma, or thyroiditis. Extrinsic infiltrative conditions affecting the thyroid gland are typically destructive, and associated with thyroid hypofunction. We describe the case of a 61-year-old woman who presented to our hospital with symptoms of thyrotoxicosis, neck swelling and thyroid function tests consistent with hyperthyroidism. Read More

J Assoc Physicians India 2016 Jan;64(1):97

Malabar Medical College Hospital and Research Centre, Calicut.

Khirurgiia (Mosk) 2016(8):13-17

Department and Clinic of Faculty Surgery, Samara State Medical University, Ministry of Health of the Russian Federation, Russia.

Aim: to define clear individual indications for different operations for diffuse toxic goiter by research of immunological markers of thyrotoxicosis recurrence probability.

Material And Methods: Long-term results of survey and treatment of 215 patients with diffuse toxic goiter are presented. Patients were divided into 2 groups. Read More

Mol Imaging Radionucl Ther 2015 Oct;24(3):135-7

Adnan Menderes University Faculty of Medicine, Department of Nuclear Medicine, Aydın, Turkey Phone: +90 256 444 12 56 E-mail:

Graves' disease (GD) may be observed as an infrequent adverse effect after radioiodine therapy (RAIT) for toxic thyroid adenoma (TA) and toxic multi nodular goiter (MNG). We present a case of a 55-year-old male with a toxic nodule who was treated with RAI. After therapy, the patient's serum free triiodothyronine (fT3) and free thyroxine (fT4) levels gradually increased. Read More

Przegl Lek 2016 ;73(4):250-61

Thyrotoxicosis is a pathological syndrome in which tissue is exposed to excessive amounts of circulating thyroid hormones. Including its subclinical form, it is considered as one of the most frequent endocrine disorders in the general population. If not detected in a timely fashion, thyrotoxicosis can have serious health consequences. Read More

J Med Assoc Thai 2016 Feb;99 Suppl 2:S123-9

Background: The main cause of hyperthyroidism is diffuse toxic goiter (Graves' disease), and the treatment of choice after medical therapy failure is radioiodine (I-131). There are two common methods of determining the optimal I-131 dose: calculated dose or fixed dose. The calculated dose method is based on the following formula: 75-200 microcuri/gram of thyroid gland divided by the percentage of radioiodine uptake at 24 hours (24-hour RAIU). Read More

Front Endocrinol (Lausanne) 2016 23;7:48. Epub 2016 May 23.

Thyroid Unit, Division of Endocrinology and Metabolism, University of São Paulo Medical School, Hospital das Clínicas , São Paulo , Brazil.

Patients with large benign goiters often present local compressive symptoms that require surgical treatment, including dysphagia, neck tightness, and airway obstruction. In contrast, patients with such goiters who remain asymptomatic may be observed after exclusion of malignancy. The use of levothyroxine (LT4) to reduce the volume of the goiter is still a controversial treatment for large goiters, and the optimal surgical procedure for multinodular goiter is still debatable. Read More

Lik Sprava 2015 Jul-Sep(5-6):87-93

Results of complex inspection of 163 girls and 192 boys of 8-17 years with the diffusion not toxic craw (DNG) are presented. At 59.4% of patients revealed disharmonious physical development. Read More

Klin Khir 2015 Nov(11):51-3

A state of autoimmunity was studied in 25 patients, suffering diffuse toxic goiter (DTG), and in 20--in nodular euthyroid goiter (NEG) before and after the operation. The level of circulating immune complexes, quantity of cytotoxic lymphocytes, the subpopulation index, the apoptosis marker were determined. There was established, that in NEG autoimmune disorders have occurred rarer and were less severe, than in DTG. Read More

Probl Radiac Med Radiobiol 2015 Dec;20:356-65

State Institution National Research Center for Radiation Medicine of National Academy of Medical Sciences of Ukraine, Melnikova str., 53, Kyiv, 04050, Ukraine.

Objective: To advance the efficiency of tooth caries prevention in children with enamel hypoplasia through a com plex intervention focused at amelioration of oral hygiene, secretory immunoglobulin A (sIgA) level, and mineral con tent of oral fluid.

Materials And Methods: Hypoplasia of permanent teeth enamel was the target of research. State of oral cavity hygiene, sIgA, total calcium and orthophosphate content in oral fluid were the research subject. Read More

Probl Radiac Med Radiobiol 2015 Dec;20:341-55

State Institution National Research Center for Radiation Medicine of National Academy of MedicalSciences of Ukraine, Melnikova str., 53, Kyiv, 04050, Ukraine.

Study Objective: To summarize the verified clinical and epidemiological data on the natural history of non cancer endocrine disease in remote period after the ChNPP accident in survivors of adult and children age.

Materials And Methods: Retrospective estimation was carried out of data on 24,588 adult persons and 20,087 chil dren survived after the ChNNP accident and being healthy or having any diseases. Data were retrieved from database of the Clinical Epidemiological Registry (CER), NRCRM for the 23 years (1992-2014) of survey. Read More

Nucl Med Commun 2016 Jan;37(1):74-8

Radiation Medicine Centre, Bhabha Atomic Research Centre, Tata Memorial Hospital Annexe, Mumbai, Maharashtra, India.

Background: Radioactive iodine (I) (RAI) is used widely for the treatment of hyperthyroidism either as a first-line treatment or following relapse after antithyroid drug treatment. Intrathyroidal retention of RAI is considered an important determinant of its effectiveness, which is believed to be prolonged by lithium.

Aims And Objectives: To study the impact of low-dose oral lithium therapy on RAI uptake and retention parameters in different subgroups of hyperthyroidism patients, and thus explore its potential role in enhancing the therapeutic efficacy of RAI in these groups of patients. Read More

Int Surg 2015 Jun;100(6):994-8

3 Department of General Surgery, Yıldırım Beyazıt University School of Medicine, Ankara, Turkey.

The purpose of this paper was to analyze the effect of Valsalva maneuver application before finalizing thyroidectomy operations on the identification of bleeding points and postoperational drainage. One hundred patients (age range, 24-76 years) with multinodular goiter, recurrent multinodular goiter, toxic diffuse multinodular goiter, or papillary thyroid cancer were included in the study and were divided into 2 groups of 50 randomly. Both groups underwent thyroidectomy operation, only 1 group received intraoperative Valsalva maneuver application (twice, 30 seconds of 30-cm PEEP). Read More

J Endocrinol Invest 2016 Apr 21;39(4):357-73. Epub 2015 Sep 21.

Thyroid Unit, Division of Endocrinology and Metabolism, Hospital das Clínicas, University of São Paulo Medical School, Av. Dr. Enéas de Carvalho Aguiar, 155 - 8th floor, bl 3, PAMB, São Paulo, 05403-900, Brazil.

Goiter, an enlargement of the thyroid gland, is a common problem in clinical practice associated with iodine deficiency, increase in serum thyroid-stimulating hormone (TSH) level, natural goitrogens, smoking, and lack of selenium and iron. Evidence suggests that heredity also has an important role in the etiology of goiter. The current classification divides goiter into diffuse and nodular, which may be further subdivided into toxic (associated with symptoms of hyperthyroidism, suppressed TSH or both), or nontoxic (associated with a normal TSH level). Read More

Case Rep Otolaryngol 2015 22;2015:829712. Epub 2015 Jun 22.

Department of Surgery, Düzce University Faculty of Medicine, 81650 Düzce, Turkey.

Thyroid hemiagenesis (TH), very rare congenital anomaly, is generally asymptomatic. We report two cases of TH with hyperthyroidism. Case One. Read More

Gig Sanit 2014 Sep-Oct(5):97-104

In the Primorsky Krai there was performed a population ecological and hygienic analysis of the relationship between the content of chemical elements in the soil and thyroid morbidity in the population of the region. The assessment of the prevalence of iodine deficiency and iodine deficiency diseases was carried out on the basis of the impact of the priority environmental toxic (strontium, nickel, cadmium, lead, arsenic, tin) and essential (nickel, iron, germanium, molybdenum, zinc, selenium) trace elements on the level of iodine deficiency diseases. The level of thyroid pathology in the territory of Primorye was established to be the highest one in areas characterized by the severe iodine deficiency (Northwest geochemical zones), where the structure of thyroid diseases is presented mainly by diffuse nontoxic goiter. Read More

Arkh Patol 2015 Sep-Oct;77(5):14-17

Moscow Regional Research Institute of Obstetrics and Gynecology, Moscow, Russia.

Objective: to compare the clinical and morphological parallels of the mother-placenta-fetus system in diffuse toxic goiter (DTG) through current morphological examinations.

Subjects And Methods: Sixty-five women whose pregnancy occurred with DTG were examined using both clinical and morphological studies (light, scanning electron, and atomic-force microscopies and macro- and microelement analysis); the placenta and uterus were investigated.

Results: Destructive changes and microrelief impairment, resulting from circulatory disorders (ischemia) and hemic hypoxia, were observed in the presence of DTG during pregnancy. Read More

Probl Radiac Med Radiobiol 2014 Sep;19:256-66

State Institution National Research Center for Radiation Medicine of the National Academy of Medical Sciences of Ukraine, Melnykov str., 53, Kyiv, 04050, Ukraine.

Study objective. Identification of the role of intersystemic hormonal interactions in development of most prevalent central and peripheral non-malignant clinical/metabolic endocrine disorders in the Chornobyl NPP accident (ChNPPA) survivors. Materials and methods. Read More

Lik Sprava 2014 Nov(11):138-42

The purpose of the present work was to study the level of microelements and vitamins in adolescents with diffuse nontoxic goiter. It has been shown that comorbid biliary dyskinesia leads to significant dysregulation of vitamin and mineral metabolism: the level of essential elements was decreased and the level of toxic elements was increased. Comorbid biliary dyskinesia in adolescents with diffuse nontoxic goiter was accompanied by a disbalance of vitamins. Read More

Value Health 2014 Nov 26;17(7):A341. Epub 2014 Oct 26.

Ivan Horbachevsky Ternopil State Medical University, Ternopil, Ukraine.

Arkh Patol 2014 May-Jun;76(3):30-2

Objective: To study the state of trophoblast and basal membranes of terminal placental villi in pregnant women with compensated diffuse toxic goiter.

Material And Methods: Placental fragments from 38-40-week pregnant women were investigated by light microscopy and immunohistochemistry using PCNA, NCL-COLL-IV, and NCL-MMP-2-507 monoclonal antibodies ("Novocastra", United Kingdom).

Results: Examination of the terminal placental villi revealed changes in their syncytiotrophoblast in the women with physiological and gestosis-complicated pregnancy and compensated diffuse toxic goiter; immunohistochemistry showed degradation of basal membranes and a change in their levels of type IV collagen. Read More

Endocrine 2015 Apr 5;48(3):1016-7. Epub 2014 Jun 5.

Department of Medicine, DIMED, University of Padova, Clinica Medica 3, Padova, Italy,

Forensic Sci Med Pathol 2014 Sep 1;10(3):452-6. Epub 2014 Jun 1.

Department of Forensic Medicine, Victorian Institute of Forensic Medicine, Monash University, 57-83 Kavanagh Street, Southbank, VIC, 3006, Australia,

Graves' disease is the most common cause of hyperthyroidism and is classically characterized by the clinical triad of diffuse toxic goiter, infiltrative ophthalmopathy with exophthalmos and an infiltrative dermopathy. While the name of the Irishman Robert Graves has received the eponymous honor, the first description of the condition in the English language can be attributed to the Englishman Caleb Perry, while in continental Europe the entity in name once honored Karl von Basedow. We present the case of a previously well 43 year old woman who presented in supraventricular tachycardia and acute pulmonary edema and died despite treatment and without a diagnosis for cause of death. Read More

BMC Endocr Disord 2014 Feb 3;14:10. Epub 2014 Feb 3.

Endocrinology Department, Carol Davila University of Medicine and Pharmacy, Elias University Hospital, 17 Marasti Blvd, sector 1, 011461 Bucharest, Romania.

Background: Thyroid dysfunction is a common complication of chronic hepatitis C (CHC) and its therapy. Takotsubo cardiomyopathy (TCM) is a multifactorial, stress related cardiomyopathy, rarely reported in association with thyrotoxicosis. Simultaneous occurrence of TCM and thyrotoxicosis due to hepatitis C and its treatment has never been reported. Read More

Horm Metab Res 2014 Jun 20;46(7):505-9. Epub 2014 Jan 20.

Postgraduation Program, Endocrinology Service, Santa Casa de Belo Horizonte, Minas Gerais, Brazil.

The objective of this prospective study was to compare the results of color flow Doppler sonography (CFDS) and radioiodine scintigraphy in patients with thyrotoxicosis. A total of 176 patients, 102 with clinical thyrotoxicosis and 74 with subclinical dysfunction, were included. Pregnant and breast-feeding women, patients using amiodarone or recently exposed to iodinated contrast, and patients treated with antithyroid drugs were excluded. Read More

Klin Med (Mosk) 2013 ;91(9):61-7

The methods for the treatment of diffuse toxic goiter (Graves'disease) are considered including analysis of 71 domestic and foreign publications with special reference to debatable and unresolved problems. The goals of and main indications for the treatment, the relevant surgical techniques, and possible complications are discussed. Comparative characteristics of the methods for the management of diffuse toxic goiter are reviewed. Read More

J Med Life 2014 ;7 Spec No. 4:54-61

Emergency Clinical Hospital "Sf. Ioan" Bucharest.

Precise and safe hemostasis is necessary for successful thyroid surgery. In this respect, the advent of the ultrasonic surgical device Harmonic Focus Curved Shears (HFCS) from Ethicon Endo-Surgery constituted a major progress in the domain by its multiple capabilities of dissection, grasping, vessel sealing and transecting. The paper presents the initial experience of 50 cases with this device of a surgical team with special interest in endocrine surgery, mostly thyroid and parathyroid. Read More

BMC Res Notes 2014 Nov 18;7:814. Epub 2014 Nov 18.

Department of Cardiology, Dhaka Medical College Hospital, Dhaka, Bangladesh.

Background: Graves' disease, a well-known cause of hyperthyroidism, is an autoimmune disease with multi-system involvement. More prevalent among young women, it appears as an uncommon cardiovascular complication during pregnancy, posing a diagnostic challenge, largely owing to difficulty in detecting the complication, as a result of a low index of suspicion of Graves' disease presenting during pregnancy. Globally, cardiovascular disease is an important factor for pregnancy-related morbidity and mortality. Read More

Klin Med (Mosk) 2014 ;92(8):50-3

We studied dynamics of hormonal status, lipid peroxidation, protein oxidative modification, enzymatic activity of the antioxidative system in the patients with newly diagnosed diffuse toxic goiter (Graves' disease). It was shown that the use of succinate-containing antioxidant reamnberin accelerates normalization of hormonal status and free radical oxidation; it reduces the duration of hospitalization. Read More

J Pak Med Assoc 2013 Mar;63(3):354-7

Medical Unit-Il, Jinnah Post Graduate Medical Center, Karachi.

Objective: To evaluate clinical symptoms, signs and various forms of thyrotoxicosis, and to assess the thyroid function status at the first 6-week follow-up.

Methods: The retrospective chart review involved thyrotoxic patients presenting at the Endocrine Clinic of Jinnah Postgraduate Medical Centre, Karachi, between April 2007 and January 2011. All hyperthyroid patients were included with the exception of those with suspected or proven malignancy. Read More

Georgian Med News 2013 May(218):67-72

The purpose of the study--estimate of thyroid tissue quantitative alteration features in different types of goiter on the operative material with a data of morphometry (stereometry) data, histology and electron microscopy in the border (neighboring) regions of Georgia and the Azerbaijan. Cohort study group made up thyroid specimens from 187 patients with nodular euthyroid and diffuse toxic goiter operated in the clinics of Azerbaijan Medical University (Baku) and the National Institute of Endocrinology in Tbilisi for the period 2010 - 2012. Results of the follicules and capillaries morphometric study indicate common clinico-morphologic manifestations of thyroid disorders in the studied regions of Georgia and Azerbaijan, as well as to: 1) determinate capacity to the hyperplastic processes in the thyroid parenchyma under the nodular euthyroid goiter, 2) the disbalance between the clinical manifestation of the disease and its growth potential, which is important to define the "biological behavior" of thyroid nodules, including relapse. Read More

Lik Sprava 2012 Dec(8):116-9

High prevalence of hyperplastic and autoimmune diseases of thyroid in Ukrainian population is determined by endemic deficit of iodine and selenium. The aim of this research was to assess the place of biologically-active additions on the basis of herbal material containing an iodine and selenium in prophylaxis and treatment of thyroid pathology. During the six month period 55 patients received herbal preparation Alba twice a day. Read More

Langenbecks Arch Surg 2013 Aug 23;398(6):887-94. Epub 2013 May 23.

Vth Surgical Clinic, University of Medicine and Pharmacy Iuliu Hatieganu, 8, Victor Babes St., 400012 Cluj-Napoca, Romania.

Purpose: The main benefits of robot-assisted transaxillary thyroid surgery are to overcome the technical limitations of other endoscopic procedures for this surgical pathology and to avoid any cervical skin incision. This article describes the first experience of a Romanian team with the endoscopic robot-assisted thyroid surgery.

Material And Methods: We used the da Vinci SI intuitive surgical system to carry out 50 thyroid operations: 33 unilateral total lobectomies with isthmectomy (TL), 8 unilateral total lobectomies, with contralateral subtotal lobectomy, and 9 total thyroidectomies. Read More

Afr J Med Med Sci 2012 Dec;41 Suppl:193-6

Department of Nuclear Medicine, University College Hospital, Ibadan, Nigeria.

Background: Graves' disease is an autoimmune disorder characterized by hyperthyroidism and associated features. Management of this disease condition for many decades has been largely by surgical and medical intervention. Usage of anti thyroid medication ameliorates the symptoms and effects of excessive production of thyroid hormones. Read More

Endocrine 2014 Feb 14;45(1):114-21. Epub 2013 May 14.

Department of Internal Medicine, Hacettepe University School of Medicine, Ankara, Turkey.

Thyroid diseases are frequently seen in patients with acromegaly. The aim of this study is to evaluate thyroid diseases and thyroid cancer in acromegalic patients followed in a single institution. The data of 92 acromegalic (43 male, 49 female) patients followed over 12 years were retrieved retrospectively from the hospital recordings. Read More

Hormones (Athens) 2012 Oct-Dec;11(4):451-7

Department of Nuclear Medicine, All India Institute of Medical Sciences, New Delhi, India.

Unlabelled: Radioactive iodine uptake (RAIU) is a test used to differentiate hyperthyroidism from thyroiditis and to calculate the radioiodine dose for treatment of Graves' disease. We aimed to evaluate the predictive role of 24h RAIU with respect to the outcome of radioiodine therapy in patients with diffuse toxic goiter (DTG).

Methods: Case records of patients with DTG treated with radioactive iodine were reviewed retrospectively. Read More

Lik Sprava 2012 Apr-Jun(3-4):99-104

The main tasks during treatment of hyperplastic thyroid diseases--to stop the growth of thyroid nodules; compensation of hypothyrosis; normalization of thyroid size. One of the perspective methods in combine therapy of diffuse and mix goiter is a phytotherapy. The most often for thyroid diseases we have used the plant drug Polentilla alba, which on Ukrainian market was registered as "Alba". Read More

Ann Endocrinol (Paris) 2012 Dec 10;73(6):542-5. Epub 2012 Nov 10.

Internal Medicine Clinic, Bezmialem Vakif University, Faculty of Medicine, 34093 Fatih, Istanbul, Turkey.

Objectives: The present study aimed to investigate the effect of smoking on thyroid nodule formation and goiter development in healthy subjects living in Istanbul, an iodine-sufficient region. This study was designed as a prospective, randomized, and observational study.

Methods: Included in the study were voluntary hospital staff and relatives of patients between the ages of 28 and 71 who had no known disease or drug use, who have been living in Istanbul and had been smoking more than 10 cigarettes per day for at least 10years. Read More

Rev Med Brux 2012 Sep;33(4):246-53

Services de Diagnostic et de Traitement par Isotopes, C.H.U. Brugmann, Bruxelles.

Circulating analytes used in the exploration of thyroid function are TSH and free thyroid hormones (FT4 and FT3). TSH is used as first line analysis in diagnosis because a normal value excludes almost always a thyroid dysfunction. However in the follow up of a treatment for hypo- or hyperthyroidism, free hormones are to be determined since TSH reaction is delayed and does not reflect precisely the restoration of euthyroidism. Read More

Niger J Clin Pract 2012 Jul-Sep;15(3):280-4

Department of Surgery, University of Maiduguri and University of Maiduguri Teaching Hospital, Nigeria.

Background: Thyrotoxicosis a common endocrine disorder of the thyroid gland in Nigeria is commonly treated surgically. The outcome of thyroidectomy for toxic goiters in Maiduguri Nigeria is evaluated.

Materials And Methods: Over the last 5 years (Jan 2005-July 2010) , in a prospective review, the demographic, and clinical data of patients operated for toxic goiters in our department was entered, into a predesigned proforma and analyzed. Read More

Arch Iran Med 2012 Aug;15(8):477-84

Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Background: There is no general agreement as to which treatment is best for hyperthyroidism. The objective of this study is to investigate the effectiveness of continuous methimazole (MMI) treatment and to compare the results of neuropsychological testing in patients receiving long-term continuous MMI to those on replacement thyroxine following radioiodine-induced (RAI) hypothyroidism.

Methods: We enrolled 239 patients with diffuse toxic goiter who had recurrences of hyperthyroidism. Read More

J Prev Med Hyg 2012 Mar;53(1):5-7

Department of Internal Medicine, University of Genoa, Italy.

The aim of this study was to assess the prevalence of non toxic goiter, difuse or nodular, in all Genoa's Country thyroid diseases. The authors have studied one non-random casuistry of 1980 Patients observed from time to time in the last decade in Ambulatory of Nuclear Medicine (Department of Internal Medicine of University of Genoa) working with Section of Hygiene of ASL of Genoa. Of 1980 patients, 1629 (83. Read More

Klin Lab Diagn 2012 Apr(4):44-6

The article deals with nowadays considerations concerning the pathogenesis of such systemic autoimmune disease as diffuse toxic goiter. The clinical monitoring of severe form of diffuse toxic goiter complicated by systemic autoimmune manifestations with characteristic alterations of results of clinical, biochemical, hormonal and immunologic analyses is analyzed. Read More

Vopr Kurortol Fizioter Lech Fiz Kult 2012 Jan-Feb(1):20-4

A total of 120 children at the age of 10-15 years presenting with class I-II obesity were available for observation. Fifty two of them suffered diffuse non-toxic goiter. The combination of obesity and diffuse non-toxic goiter was associated with excessive body weight, insulin resistance, disturbances of lipid metabolism, and impaired tolerance of physical exercises. Read More

Horm Metab Res 2012 Apr 14;44(4):255-62. Epub 2012 Feb 14.

Department of Endocrinology-Endocrine Oncology, Theagenion Cancer Hospital, Thessaloniki, Greece.

Thyroid cancer can be associated with thyrotoxicosis caused by Graves' disease, toxic multinodular goiter, or autonomously functioning thyroid adenoma. The objective of this study was to summarize current evidence regarding the association of thyroid cancer and hyperthyroidism, particularly with respect to the type of hyperthyroidism found in some patients, and whether this affects the outcome of the patient. A PubMed search was performed up to August 2011. Read More

Vestn Khir Im I I Grek 2011 ;170(5):31-4

The article presents a comparison and analysis of clinical and morphological data obtained in surgical treatment of 743 thyrotoxicosis patients operated in clinical bases of the Saint Petersburg Center of surgery of organs of the endocrine system at the period from 2005 through 2010. Causes of disagreement of the clinical diagnosis and morphological conclusion in patients with different diseases of the thyroid gland resulting in thyrotoxicosis are considered. Great clinical material (743 observations) was used by the authors to demonstrate the diagnostic value of special methods of investigation of the thyroid gland in patients with the toxic goiter. Read More

Endocrine 2012 Jun 30;41(3):532-8. Epub 2011 Dec 30.

Laboratório de Fisiologia Endócrina Doris Rosenthal, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, CCS, bloco G, Cidade Universitária, Ilha do Fundão, Rio de Janeiro, 21949-900, Brazil.

Type 1 (D1) and 2 (D2) iodothyronine deiodinases are selenocysteine-containing enzymes that catalyze the deiodination of T4 to T3 in the thyroid and in peripheral tissues. Despite their importance to the plasma T3 pool in human beings, there are few studies about their behavior in human thyroids. In order to better understand iodothyronine deiodinase regulation in the thyroid gland, we studied thyroid tissue samples from follicular adenoma (AD, n = 5), toxic diffuse goiter (TDG, n = 6), nontoxic multinodular goiter (NMG, n = 40), papillary thyroid carcinoma (PTC, n = 8), and surrounding normal tissues (NT, n = 7) from 36 patients submitted to elective thyroidectomy. Read More

Vestn Khir Im I I Grek 2011 ;170(4):58-63

Quality of life of 89 patients with diffuse toxic goiter was analyzed before surgical intervention and at different terms after thyroidectomy or terminal subtotal resection of the thyroid gland using questionnaire SF-36. It was found that quality of life of patients with diffuse toxic goiter was lower than that of respondents without such pathology. The indices of quality of life one year after thyroidectomy (terminal subtotal resection of the thyroid gland) remained depending on the duration of the disease and complications of thyrotoxicosis, became reliably larger as compared with preoperative level due to social activity and emotional state. Read More