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Clin Otolaryngol 2020 Mar 9. Epub 2020 Mar 9.

ENT Consultant, Surrey & Sussex NHS Trust, Redhill, UK.

Introduction: Hyperthyroidism (HT) has been associated with no insignificant rates of thyroid malignancy. There are no current specific guidelines that suggest routine preoperative imaging for thyroid nodules in patients with Grave's disease. We therefore performed a systematic review assessing rates of thyroid malignancy in patients undergoing surgery for different causes of HT: Grave's disease (GD), toxic adenoma (TA) and toxic multinodular goitre (TMNG). Read More

Ethiop J Health Sci 2020 Jan;30(1):31-36

Surgery and Renal Transplant Surgeon, St. Paulos Hospital Millennium Medical College.

Background: Thyroid disease is a common disorder of the endocrine system worldwide. It is a common problem in developing countries, including Ethiopia. The aim of this study was to determine the burden and the pattern of thyroid disease in St. Read More

Kardiologiia 2019 Jul 24;59(6S):61-64. Epub 2019 Jul 24.

I. M. Sechenov First Moscow State Medical University (Sechenov University).

We present a case of a patient with pronounced edematous‑ascitic syndrome. Initially, its causes were considered to be alcoholic cardiomyopathy (right ventricular failure) with heart rhythm disturbances and liver cirrhosis. Targeted treatment had a low clinical effect, which served as a basis for revising the diagnostic concept. Read More

Pan Afr Med J 2018 2;31:72. Epub 2018 Oct 2.

Service d'Hépato-Gastroentérologie de l'Hôpital Aritide Le Dantec, Dakar, Sénégal.

Hepatic impairment is common during hyperthyroidism. It is most often asymptomatic. Hyperthyroidism revealed by jaundice has been rarely described in the literature. Read More

Thyroid 2019 04 22;29(4):595-606. Epub 2019 Mar 22.

1 School of Medicine, Department of Normal and Pathological Cytology and Histology, University of Seville, Seville, Spain.

Background: Primary cilia (PC) are conserved structures in the adult thyroid gland of different mammals. It was recently described that in humans, PC are usually present as a single copy per follicular cell emerging from the follicular cell apex into the follicular lumen.

Methods: To understand the role developed by PC in thyroid hormonogenesis better, their changes in different human functional thyroid diseases (diffuse toxic hyperplasia/Graves' disease [GD] and nodular hyperplasia [NH]/nodular goiter), in comparison to normal thyroid tissue, were investigated using immunofluorescence, morphometry, and electron microscopy analyses. Read More

Vestn Oftalmol 2018;134(2):23-31

State Research Center of Preventive Medicine, Ministry of Health of the Russian Federation, 10 building 3 Petroverigsky per., Moscow, Russian Federation, 101990.

Endocrine ophthalmopathy (EOP) is a severe chronic autoimmune disease associated with autoimmune thyroid pathology that leads to loss of sight, cosmetic defects and quality of life decrease. EOP is difficult to give prognosis for due to various factors affecting its course and outcome.

Purpose: To develop a reliable and precise prognosis method for EOP activity and severity based on personalized combination of risk factors in specific patients by multidimensional linear regression modeling. Read More

J Pediatr Endocrinol Metab 2018 Apr;31(5):589-593

Department of Pediatric Endocrinology, Dokuz Eylul University, Faculty of Medicine, Izmir, Turkey.

Background: Similar autoimmune processes (defective T-cell function) take place during the pathogenesis of aplastic anemia (AA) and Graves' disease (GD). Antithyroid drugs used for the management of GD may induce AA and GD may occur following treatment of severe aplastic anemia (SAA).

Case Presentation: Clinical and laboratory investigations were performed for an 11-year-and-2-month-old girl who was referred for bilateral exophthalmus and abnormal thyroid function tests. Read More

J Endocrinol Invest 2018 Sep 20;41(9):1019-1028. Epub 2018 Jan 20.

Endocrinology, Diabetes and Metabolism Unit, Department of Internal Medicine, Hospital of Egas Moniz, Lisbon's Occidental Center of Hospitals, Estrada do Forte do Alto do Duque, 1449-005, Lisbon, Portugal.

Background: Graves' disease (GD) arising after the treatment of toxic multinodular goitre (TMNG) with radioiodine has long been described but it remained unclear whether GD was in fact iodine induced, its incidence, risk factors, natural history and treatment outcomes.

Methods: A systematic search using The Cochrane Library, Medline and PubMed Central allowed the pooling of data from 3633 patients with thyroid autonomy, 1340 patients with TMNG, to fill gaps in knowledge, regarding the clinical expression of iodine-induced GD (I-IGD) in adults.

Results: I-IGD developed in 0-5. Read More

J Pediatr Endocrinol Metab 2018 Jan;31(2):159-165

Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, I.R. Iran.

Background: Diffuse toxic goiter accounts for about 15% of all childhood thyroid diseases. There is great controversy over the management of Graves' disease in children and adolescents. This article reports our experience in 304 children and juvenile patients with Graves' disease. Read More

Fa Yi Xue Za Zhi 2017 Oct 25;33(5):482-485. Epub 2017 Oct 25.

Department of Forensic Pathology, School of Forensic Medicine, China Medical University, Shenyang 110122, China.

Objectives: To analyse the cases of sudden death due to hyperthyroid heart disease, and explore the general information of deaths and the forensic pathological characteristics to provide reference evidence for forensic identification of such cases.

Methods: Six cases of sudden death due to hyperthyroid heart disease between 2001 and 2016 were selected from School of Forensic Medicine, China Medical University. The general information （gender and age）, clinical manifestations, medical history, anatomical and histopathological findings, biochemical parameters and cause of death were analysed retrospectively. Read More

Arkh Patol 2017;79(6):3-7

Acad. I.P. Pavlov Saint Petersburg State Medical University, Ministry of Health of the Russian Federation, Saint Petersburg, Russia.

The pathogenesis of diffuse toxic goiter has not yet been fully understood. The literature increasing commonly focusses on the issues related to the processes occurring in the thyroid gland itself: proliferation, apoptosis, and angiogenesis.

Aim: to investigate clinical and laboratory parameters, as well as the expression of Ki-67, Bcl-2, Bax, Fas-L, CD34, VEGF, and FGF proteins in various postoperative outcomes of patients operated on for diffuse toxic goiter. Read More

Mediterr J Hematol Infect Dis 2017 16;9(1):e2017058. Epub 2017 Oct 16.

Division of Hematology, University Hospital-Santa Maria Misericordia, Udine, Italy.

Antithyroid drugs can be a rare cause of agranulocytosis (0.5% of treated patients). Suspension of these drugs is mandatory in these patients and may result in worsening hyperthyroidism. Read More

Int J Biol Macromol 2018 Feb 25;107(Pt B):2484-2491. Epub 2017 Oct 25.

G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch, Russian Academy of Sciences, Prospect 100 let Vladivostoku, 159, Vladivostok, 690022, Russia.

This work is devoted to the ascertainment of serological cross-reactivity between OmpF porin from Yersinia pseudotuberculosis (YpOmpF) and human thyroid-stimulating hormone receptor (hTSHR). Extracts containing hTSHR were isolated from surgical thyroid tissue of patients with clinical and diagnostic signs of diffuse toxic goiter. Monoclonal antibodies to hTSHR (mAbs) were shown to interact both with antigens in thyroid tissue extracts and with YpOmpF. Read More

Int J Surg 2017 Dec 10;48:180-188. Epub 2017 Oct 10.

Division for Endocrine and Minimally Invasive Surgery, Department of Human Pathology in Adulthood and Childhood "G. Barresi", University Hospital G. Martino, University of Messina, Via C. Valeria 1, 98125, Messina, Italy. Electronic address:

Purpose: The increasing use of intraoperative neural monitoring (IONM) of the recurrent laryngeal nerve (RLN) during thyroid surgery imposes an evaluation of cost-effectiveness.

Methods: The analysis estimated the cost versus utility of different alternatives that simulate nerve injury course and the consequences for the following cohorts of patients: (1) no RLN injury, or vocal fold palsy (VCP) recovery within 1 month (2), 2 months (3), 6 months (4), and after 12 months (5). In the model applied, the average simulated cohort consisted of a young female patient, 40 years old, employed, daily voice user, who underwent elective, conventional total thyroidectomy via cervical incision using a standardized intermittent IONM technique, for an operable benign, bilateral, diffuse, multinodular, non-toxic, non-retrosternal goiter. Read More

Med Arch 2017 Aug;71(4):270-273

Clinic of Nuclear Medicine and Endocrinology, University Clinical Center Sarajevo, Sarajevo, Bosnia and Herzegovina.

Introduction: Consensus hasn't been yet achieved about optimal dose quantity that could prevent post therapy hypothyroidism, thus dosing approach varies among different centers. I131 doses can be fixed or calculated, although treatment outcomes don't differ significantly according to recent acknowledgments.

Aim: Determination of the incidence of hypothyroidism after radioiodine treatment (I131) in dependence of hyperthyroidism etiology and quantity of applied doses. Read More

Khirurgiia (Mosk) 2017(8):13-17

Pavlov Ryazan State Medical University, Ryazan, Russia.

Aim: To analyze long-term outcomes of Graves' disease management.

Material And Methods: There were 428 patients for the periods 2000-2004 and 2005-2010. Patients were called for examination and thyroid status control. Read More

Transl Neurosci 2017 30;8:27-30. Epub 2017 Apr 30.

Division of Endocrinology and Metabolism, Department of Internal Medicine, Taipei Medical University Hospital, Taipei, Taiwan.

Background: Some of the thyroid disorders (TD) and Myasthenia gravis (MG) are autoimmune related disease. The purpose of the study to evaluate the relationship of MG with all morphological and functional thyroid disorders.

Methods: We constructed a population-based cohort study during the period from January 2000-December 2002 by using reimbursement data from the Bureau National Health Insurance (NHI) system in Taiwan. Read More

Oxf Med Case Reports 2016 Nov 4;2016(11):omw082. Epub 2016 Nov 4.

Consultant Medical Oncologist, University Hospital Limerick , Limerick , Ireland.

Thyrotoxicosis is most commonly caused by Graves' disease, toxic multinodular goitre, a functioning thyroid adenoma, or thyroiditis. Extrinsic infiltrative conditions affecting the thyroid gland are typically destructive, and associated with thyroid hypofunction. We describe the case of a 61-year-old woman who presented to our hospital with symptoms of thyrotoxicosis, neck swelling and thyroid function tests consistent with hyperthyroidism. Read More

Khirurgiia (Mosk) 2016(8):13-17

Department and Clinic of Faculty Surgery, Samara State Medical University, Ministry of Health of the Russian Federation, Russia.

Aim: to define clear individual indications for different operations for diffuse toxic goiter by research of immunological markers of thyrotoxicosis recurrence probability.

Material And Methods: Long-term results of survey and treatment of 215 patients with diffuse toxic goiter are presented. Patients were divided into 2 groups. Read More

Mol Imaging Radionucl Ther 2015 Oct;24(3):135-7

Adnan Menderes University Faculty of Medicine, Department of Nuclear Medicine, Aydın, Turkey Phone: +90 256 444 12 56 E-mail:

Graves' disease (GD) may be observed as an infrequent adverse effect after radioiodine therapy (RAIT) for toxic thyroid adenoma (TA) and toxic multi nodular goiter (MNG). We present a case of a 55-year-old male with a toxic nodule who was treated with RAI. After therapy, the patient's serum free triiodothyronine (fT3) and free thyroxine (fT4) levels gradually increased. Read More

Przegl Lek 2016 ;73(4):250-61

Thyrotoxicosis is a pathological syndrome in which tissue is exposed to excessive amounts of circulating thyroid hormones. Including its subclinical form, it is considered as one of the most frequent endocrine disorders in the general population. If not detected in a timely fashion, thyrotoxicosis can have serious health consequences. Read More

J Med Assoc Thai 2016 Feb;99 Suppl 2:S123-9

Background: The main cause of hyperthyroidism is diffuse toxic goiter (Graves' disease), and the treatment of choice after medical therapy failure is radioiodine (I-131). There are two common methods of determining the optimal I-131 dose: calculated dose or fixed dose. The calculated dose method is based on the following formula: 75-200 microcuri/gram of thyroid gland divided by the percentage of radioiodine uptake at 24 hours (24-hour RAIU). Read More

Front Endocrinol (Lausanne) 2016 23;7:48. Epub 2016 May 23.

Thyroid Unit, Division of Endocrinology and Metabolism, University of São Paulo Medical School, Hospital das Clínicas , São Paulo , Brazil.

Patients with large benign goiters often present local compressive symptoms that require surgical treatment, including dysphagia, neck tightness, and airway obstruction. In contrast, patients with such goiters who remain asymptomatic may be observed after exclusion of malignancy. The use of levothyroxine (LT4) to reduce the volume of the goiter is still a controversial treatment for large goiters, and the optimal surgical procedure for multinodular goiter is still debatable. Read More

Lik Sprava 2015 Jul-Sep(5-6):87-93

Results of complex inspection of 163 girls and 192 boys of 8-17 years with the diffusion not toxic craw (DNG) are presented. At 59.4% of patients revealed disharmonious physical development. Read More

Klin Khir 2015 Nov(11):51-3

A state of autoimmunity was studied in 25 patients, suffering diffuse toxic goiter (DTG), and in 20--in nodular euthyroid goiter (NEG) before and after the operation. The level of circulating immune complexes, quantity of cytotoxic lymphocytes, the subpopulation index, the apoptosis marker were determined. There was established, that in NEG autoimmune disorders have occurred rarer and were less severe, than in DTG. Read More

Klin Med (Mosk) 2016;94(4):260-264

The state of the cardiovascular system was studied in patients with type 2 diabetes mellitus and thyroid disorders in the absence of thyroid gland dysfunction. 76.9% of the 302 patients with DM2 had thyroid pathology; in 23,8% it was not previously diagnosed. Read More

Probl Radiac Med Radiobiol 2015 Dec;20:356-65

State Institution National Research Center for Radiation Medicine of National Academy of Medical Sciences of Ukraine, Melnikova str., 53, Kyiv, 04050, Ukraine.

Objective: To advance the efficiency of tooth caries prevention in children with enamel hypoplasia through a com plex intervention focused at amelioration of oral hygiene, secretory immunoglobulin A (sIgA) level, and mineral con tent of oral fluid.

Materials And Methods: Hypoplasia of permanent teeth enamel was the target of research. State of oral cavity hygiene, sIgA, total calcium and orthophosphate content in oral fluid were the research subject. Read More

Probl Radiac Med Radiobiol 2015 Dec;20:341-55

State Institution National Research Center for Radiation Medicine of National Academy of MedicalSciences of Ukraine, Melnikova str., 53, Kyiv, 04050, Ukraine.

Study Objective: To summarize the verified clinical and epidemiological data on the natural history of non cancer endocrine disease in remote period after the ChNPP accident in survivors of adult and children age.

Materials And Methods: Retrospective estimation was carried out of data on 24,588 adult persons and 20,087 chil dren survived after the ChNNP accident and being healthy or having any diseases. Data were retrieved from database of the Clinical Epidemiological Registry (CER), NRCRM for the 23 years (1992-2014) of survey. Read More

Nucl Med Commun 2016 Jan;37(1):74-8

Radiation Medicine Centre, Bhabha Atomic Research Centre, Tata Memorial Hospital Annexe, Mumbai, Maharashtra, India.

Background: Radioactive iodine (I) (RAI) is used widely for the treatment of hyperthyroidism either as a first-line treatment or following relapse after antithyroid drug treatment. Intrathyroidal retention of RAI is considered an important determinant of its effectiveness, which is believed to be prolonged by lithium.

Aims And Objectives: To study the impact of low-dose oral lithium therapy on RAI uptake and retention parameters in different subgroups of hyperthyroidism patients, and thus explore its potential role in enhancing the therapeutic efficacy of RAI in these groups of patients. Read More

Int Surg 2015 Jun;100(6):994-8

3 Department of General Surgery, Yıldırım Beyazıt University School of Medicine, Ankara, Turkey.

The purpose of this paper was to analyze the effect of Valsalva maneuver application before finalizing thyroidectomy operations on the identification of bleeding points and postoperational drainage. One hundred patients (age range, 24-76 years) with multinodular goiter, recurrent multinodular goiter, toxic diffuse multinodular goiter, or papillary thyroid cancer were included in the study and were divided into 2 groups of 50 randomly. Both groups underwent thyroidectomy operation, only 1 group received intraoperative Valsalva maneuver application (twice, 30 seconds of 30-cm PEEP). Read More

J Endocrinol Invest 2016 Apr 21;39(4):357-73. Epub 2015 Sep 21.

Thyroid Unit, Division of Endocrinology and Metabolism, Hospital das Clínicas, University of São Paulo Medical School, Av. Dr. Enéas de Carvalho Aguiar, 155 - 8th floor, bl 3, PAMB, São Paulo, 05403-900, Brazil.

Goiter, an enlargement of the thyroid gland, is a common problem in clinical practice associated with iodine deficiency, increase in serum thyroid-stimulating hormone (TSH) level, natural goitrogens, smoking, and lack of selenium and iron. Evidence suggests that heredity also has an important role in the etiology of goiter. The current classification divides goiter into diffuse and nodular, which may be further subdivided into toxic (associated with symptoms of hyperthyroidism, suppressed TSH or both), or nontoxic (associated with a normal TSH level). Read More

Case Rep Otolaryngol 2015 22;2015:829712. Epub 2015 Jun 22.

Department of Surgery, Düzce University Faculty of Medicine, 81650 Düzce, Turkey.

Thyroid hemiagenesis (TH), very rare congenital anomaly, is generally asymptomatic. We report two cases of TH with hyperthyroidism. Case One. Read More

Gig Sanit 2014 Sep-Oct(5):97-104

In the Primorsky Krai there was performed a population ecological and hygienic analysis of the relationship between the content of chemical elements in the soil and thyroid morbidity in the population of the region. The assessment of the prevalence of iodine deficiency and iodine deficiency diseases was carried out on the basis of the impact of the priority environmental toxic (strontium, nickel, cadmium, lead, arsenic, tin) and essential (nickel, iron, germanium, molybdenum, zinc, selenium) trace elements on the level of iodine deficiency diseases. The level of thyroid pathology in the territory of Primorye was established to be the highest one in areas characterized by the severe iodine deficiency (Northwest geochemical zones), where the structure of thyroid diseases is presented mainly by diffuse nontoxic goiter. Read More

Arkh Patol 2015 Sep-Oct;77(5):14-17

Moscow Regional Research Institute of Obstetrics and Gynecology, Moscow, Russia.

Objective: to compare the clinical and morphological parallels of the mother-placenta-fetus system in diffuse toxic goiter (DTG) through current morphological examinations.

Subjects And Methods: Sixty-five women whose pregnancy occurred with DTG were examined using both clinical and morphological studies (light, scanning electron, and atomic-force microscopies and macro- and microelement analysis); the placenta and uterus were investigated.

Results: Destructive changes and microrelief impairment, resulting from circulatory disorders (ischemia) and hemic hypoxia, were observed in the presence of DTG during pregnancy. Read More

Probl Radiac Med Radiobiol 2014 Sep;19:256-66

State Institution National Research Center for Radiation Medicine of the National Academy of Medical Sciences of Ukraine, Melnykov str., 53, Kyiv, 04050, Ukraine.

Study objective. Identification of the role of intersystemic hormonal interactions in development of most prevalent central and peripheral non-malignant clinical/metabolic endocrine disorders in the Chornobyl NPP accident (ChNPPA) survivors. Materials and methods. Read More

Lik Sprava 2014 Nov(11):138-42

The purpose of the present work was to study the level of microelements and vitamins in adolescents with diffuse nontoxic goiter. It has been shown that comorbid biliary dyskinesia leads to significant dysregulation of vitamin and mineral metabolism: the level of essential elements was decreased and the level of toxic elements was increased. Comorbid biliary dyskinesia in adolescents with diffuse nontoxic goiter was accompanied by a disbalance of vitamins. Read More

Value Health 2014 Nov 26;17(7):A341. Epub 2014 Oct 26.

Ivan Horbachevsky Ternopil State Medical University, Ternopil, Ukraine.

Arkh Patol 2014 May-Jun;76(3):30-2

Objective: To study the state of trophoblast and basal membranes of terminal placental villi in pregnant women with compensated diffuse toxic goiter.

Material And Methods: Placental fragments from 38-40-week pregnant women were investigated by light microscopy and immunohistochemistry using PCNA, NCL-COLL-IV, and NCL-MMP-2-507 monoclonal antibodies ("Novocastra", United Kingdom).

Results: Examination of the terminal placental villi revealed changes in their syncytiotrophoblast in the women with physiological and gestosis-complicated pregnancy and compensated diffuse toxic goiter; immunohistochemistry showed degradation of basal membranes and a change in their levels of type IV collagen. Read More

Endocrine 2015 Apr 5;48(3):1016-7. Epub 2014 Jun 5.

Department of Medicine, DIMED, University of Padova, Clinica Medica 3, Padova, Italy,

Forensic Sci Med Pathol 2014 Sep 1;10(3):452-6. Epub 2014 Jun 1.

Department of Forensic Medicine, Victorian Institute of Forensic Medicine, Monash University, 57-83 Kavanagh Street, Southbank, VIC, 3006, Australia,

Graves' disease is the most common cause of hyperthyroidism and is classically characterized by the clinical triad of diffuse toxic goiter, infiltrative ophthalmopathy with exophthalmos and an infiltrative dermopathy. While the name of the Irishman Robert Graves has received the eponymous honor, the first description of the condition in the English language can be attributed to the Englishman Caleb Perry, while in continental Europe the entity in name once honored Karl von Basedow. We present the case of a previously well 43 year old woman who presented in supraventricular tachycardia and acute pulmonary edema and died despite treatment and without a diagnosis for cause of death. Read More

BMC Endocr Disord 2014 Feb 3;14:10. Epub 2014 Feb 3.

Endocrinology Department, Carol Davila University of Medicine and Pharmacy, Elias University Hospital, 17 Marasti Blvd, sector 1, 011461 Bucharest, Romania.

Background: Thyroid dysfunction is a common complication of chronic hepatitis C (CHC) and its therapy. Takotsubo cardiomyopathy (TCM) is a multifactorial, stress related cardiomyopathy, rarely reported in association with thyrotoxicosis. Simultaneous occurrence of TCM and thyrotoxicosis due to hepatitis C and its treatment has never been reported. Read More

Horm Metab Res 2014 Jun 20;46(7):505-9. Epub 2014 Jan 20.

Postgraduation Program, Endocrinology Service, Santa Casa de Belo Horizonte, Minas Gerais, Brazil.

The objective of this prospective study was to compare the results of color flow Doppler sonography (CFDS) and radioiodine scintigraphy in patients with thyrotoxicosis. A total of 176 patients, 102 with clinical thyrotoxicosis and 74 with subclinical dysfunction, were included. Pregnant and breast-feeding women, patients using amiodarone or recently exposed to iodinated contrast, and patients treated with antithyroid drugs were excluded. Read More

Klin Med (Mosk) 2013 ;91(9):61-7

The methods for the treatment of diffuse toxic goiter (Graves'disease) are considered including analysis of 71 domestic and foreign publications with special reference to debatable and unresolved problems. The goals of and main indications for the treatment, the relevant surgical techniques, and possible complications are discussed. Comparative characteristics of the methods for the management of diffuse toxic goiter are reviewed. Read More

J Med Life 2014 ;7 Spec No. 4:54-61

Emergency Clinical Hospital "Sf. Ioan" Bucharest.

Precise and safe hemostasis is necessary for successful thyroid surgery. In this respect, the advent of the ultrasonic surgical device Harmonic Focus Curved Shears (HFCS) from Ethicon Endo-Surgery constituted a major progress in the domain by its multiple capabilities of dissection, grasping, vessel sealing and transecting. The paper presents the initial experience of 50 cases with this device of a surgical team with special interest in endocrine surgery, mostly thyroid and parathyroid. Read More

BMC Res Notes 2014 Nov 18;7:814. Epub 2014 Nov 18.

Department of Cardiology, Dhaka Medical College Hospital, Dhaka, Bangladesh.

Background: Graves' disease, a well-known cause of hyperthyroidism, is an autoimmune disease with multi-system involvement. More prevalent among young women, it appears as an uncommon cardiovascular complication during pregnancy, posing a diagnostic challenge, largely owing to difficulty in detecting the complication, as a result of a low index of suspicion of Graves' disease presenting during pregnancy. Globally, cardiovascular disease is an important factor for pregnancy-related morbidity and mortality. Read More

Klin Med (Mosk) 2014 ;92(8):50-3

We studied dynamics of hormonal status, lipid peroxidation, protein oxidative modification, enzymatic activity of the antioxidative system in the patients with newly diagnosed diffuse toxic goiter (Graves' disease). It was shown that the use of succinate-containing antioxidant reamnberin accelerates normalization of hormonal status and free radical oxidation; it reduces the duration of hospitalization. Read More

J Pak Med Assoc 2013 Mar;63(3):354-7

Medical Unit-Il, Jinnah Post Graduate Medical Center, Karachi.

Objective: To evaluate clinical symptoms, signs and various forms of thyrotoxicosis, and to assess the thyroid function status at the first 6-week follow-up.

Methods: The retrospective chart review involved thyrotoxic patients presenting at the Endocrine Clinic of Jinnah Postgraduate Medical Centre, Karachi, between April 2007 and January 2011. All hyperthyroid patients were included with the exception of those with suspected or proven malignancy. Read More

Georgian Med News 2013 May(218):67-72

The purpose of the study--estimate of thyroid tissue quantitative alteration features in different types of goiter on the operative material with a data of morphometry (stereometry) data, histology and electron microscopy in the border (neighboring) regions of Georgia and the Azerbaijan. Cohort study group made up thyroid specimens from 187 patients with nodular euthyroid and diffuse toxic goiter operated in the clinics of Azerbaijan Medical University (Baku) and the National Institute of Endocrinology in Tbilisi for the period 2010 - 2012. Results of the follicules and capillaries morphometric study indicate common clinico-morphologic manifestations of thyroid disorders in the studied regions of Georgia and Azerbaijan, as well as to: 1) determinate capacity to the hyperplastic processes in the thyroid parenchyma under the nodular euthyroid goiter, 2) the disbalance between the clinical manifestation of the disease and its growth potential, which is important to define the "biological behavior" of thyroid nodules, including relapse. Read More

Lik Sprava 2012 Dec(8):116-9

High prevalence of hyperplastic and autoimmune diseases of thyroid in Ukrainian population is determined by endemic deficit of iodine and selenium. The aim of this research was to assess the place of biologically-active additions on the basis of herbal material containing an iodine and selenium in prophylaxis and treatment of thyroid pathology. During the six month period 55 patients received herbal preparation Alba twice a day. Read More