39,089 results match your criteria Goiter


Changes in Weight and Nutritional Habits in Adults with Obesity during the "Lockdown" Period Caused by the COVID-19 Virus Emergency.

Nutrients 2020 Jul 7;12(7). Epub 2020 Jul 7.

Department of Medical Sciences, University of Torino, c.so AM Dogliotti 14, 10126 Torino, Italy.

Our aim is evaluating the changes in weight and dietary habits in a sample of outpatients with obesity after 1 month of enforced lockdown during the COVID-19 pandemic in Northern Italy. In this observational retrospective study, the patients of our Obesity Unit were invited to answer to a 12-question multiple-choice questionnaire relative to weight changes, working activity, exercise, dietary habits, and conditions potentially impacting on nutritional choices. A multivariate regression analysis was performed to evaluate the associations among weight/BMI changes and the analyzed variables. Read More

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http://dx.doi.org/10.3390/nu12072016DOI Listing

Roles of Thyroid Hormones, Mast Cells, and Inflammatory Mediators in the Initiation and Progression of Autoimmune Thyroid Diseases.

Int Arch Allergy Immunol 2020 Jul 8:1-12. Epub 2020 Jul 8.

Department of Clinical Immunology and Allergy Sechenov, First Moscow State Medical University, Moscow, Russian Federation.

Background: Interrelation between thyrocytes and immunocytes has been established. However, the roles of mast cells and thyroid hormones in the triggering mechanism of thyroid autoimmune processes have been insufficiently investigated. This study evaluated the role of thyroid hormones and mast cells in the mechanisms of losing tolerance to thyroid autoantigens. Read More

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http://dx.doi.org/10.1159/000508937DOI Listing

Applying Amide Proton Transfer-Weighted Imaging (APTWI) to Distinguish Papillary Thyroid Carcinomas and Predominantly Solid Adenomatous Nodules: Comparison With Diffusion-Weighted Imaging.

Front Oncol 2020 19;10:918. Epub 2020 Jun 19.

The Department of Medical Imaging, Guangdong Second Provincial General Hospital, Guangzhou, China.

Amide proton transfer-weighted (ATPw) imaging is a novel MRI technique that has been used to identify benign and malignant tumors. The present study evaluated the role of APTw imaging in differentiating papillary thyroid carcinoma from predominantly solid adenomatous nodule. This study included 24 cases of solitary papillary thyroid carcinoma, and 20 cases of solid adenomatous nodules. Read More

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http://dx.doi.org/10.3389/fonc.2020.00918DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7317983PMC

A rare coexistence of papillary carcinoma and anaplastic carcinoma of thyroid in multinodular goitre: Case report and literature review.

Ann Med Surg (Lond) 2020 Aug 27;56:161-164. Epub 2020 Jun 27.

Otorhinolaryngology Head and Neck Surgery, National Academy of Medical Sciences, Bir Hospital, Kathmandu, Nepal.

Introduction: Multinodular goiter is defined as multiple discrete nodules in the thyroid gland. The incidence of Papillary carcinoma thyroid was found to be highest out of total Multinodular Goiter cases while that of Anaplastic carcinoma was the least. We report a rare coexistence of Papillary carcinoma and Anaplastic carcinoma in adult patient with a long-standing Multinodular Goiter. Read More

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http://dx.doi.org/10.1016/j.amsu.2020.06.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7330161PMC

[Medullary thyroid carcinoma and multiple endocrine neoplasia type 2].

Dtsch Med Wochenschr 2020 Jul 7. Epub 2020 Jul 7.

Medullary thyroid carcinoma (MTC) is a rare malignancy and compromises only 3 % of all thyroid carcinomas. MTC cells secret calcitonin, which serves as a sensitive tumor marker for screening and follow-up of MTC. Calcitonin screening in patients with nodular goiter allows for early diagnosis of MTC and surgical curative treatment. Read More

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http://dx.doi.org/10.1055/a-1005-8798DOI Listing

[Thyroid nodules: The Guidelines of the American Thyroid Association from a European Perspective].

Dtsch Med Wochenschr 2020 Jul 7. Epub 2020 Jul 7.

In Germany and in other regions with former iodine deficiency, thyroid nodules and nodular goiter are still much more frequent than in the U.S.A. Read More

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http://dx.doi.org/10.1055/a-1018-2767DOI Listing

Anaplastic Thyroid Cancer Arising from Dyshormonogenetic Goiter: c.3070T>C and Novel c.7070T>C Mutation in the Thyroglobulin Gene.

Thyroid 2020 Jul 6. Epub 2020 Jul 6.

Department of Internal Medicine, Chonnam University Medical School, Gwangju, Republic of Korea.

Concomitant thyroid cancer in patients with congenital thyroid dyshormonogenesis (TD) is extremely rare and few cases of differentiated thyroid cancer in patients with TD have been reported thus far. In this study, we describe anaplastic thyroid cancer in a 46-year-old woman with TD who had two germline thyroglobulin () gene mutation, c.3790T>C (p, Cys1264Arg) in exon 17 and a novel c. Read More

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http://dx.doi.org/10.1089/thy.2020.0248DOI Listing

Effect of lithium carbonate on the function of the thyroid gland: mechanism of action and clinical implications.

J Physiol Pharmacol 2020 Apr 2;71(2). Epub 2020 Jul 2.

Chair and Department of Endocrinology, Metabolism and Internal Medicine, Poznan University of Medical Sciences, Poznan, Poland.

Lithium carbonate, a drug known for more than 100 years, has been successfully used as a psychiatric medication. Currently, it is a commonly used drug to treat patients with unipolar and bipolar depression, and for the prophylaxis of bipolar disorders and acute mania. Lithium salts may cause the development of goiter, hypothyroidism, or rarely hyperthyroidism. Read More

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http://dx.doi.org/10.26402/jpp.2020.2.03DOI Listing

Scintigraphy evaluation of hyperthyroidism and its correlation with clinical and biochemical profiles.

BMC Res Notes 2020 Jul 6;13(1):324. Epub 2020 Jul 6.

Taif University School of Medicine, Taif, Saudi Arabia.

Objective: Hyperthyroidism is the excessive synthesis of thyroid hormones. Thyroid uptake scans and ultrasonography provide an accurate diagnosis of hyperthyroidism, especially when thyroid receptor antibody (TRAb) measurement is not readily available. This study explored the prevalence of various hyperthyroidism causes using retrospective scintigraphy results and evaluated their relationship with clinical, biochemical, and sonographic imaging parameters from patients who underwent Tc-pertechnetate thyroid scans between 2016 and 2019 in Taif, Saudi Arabia, where literature is insufficient. Read More

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http://dx.doi.org/10.1186/s13104-020-05164-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7339512PMC

Endocrine Dysfunction Following Stroke.

J Neuroimmune Pharmacol 2020 Jul 3. Epub 2020 Jul 3.

Department of Pharmacology, University of Vermont College of Medicine, Burlington, VT, 05405-0068, USA.

Endocrine dysfunction is known to occur after traumatic brain injury. The purpose of this study was to examine the incidence of various endocrine dysfunctions after a stroke. The Taiwan National Health Insurance Research Database (NHIRD) was searched from 2001 to 2011 for patients with a diagnosis of stroke. Read More

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http://dx.doi.org/10.1007/s11481-020-09935-6DOI Listing

Plasma Metabolic Profiling of Human Thyroid Nodules by Gas Chromatography-Mass Spectrometry (GC-MS)-Based Untargeted Metabolomics.

Front Cell Dev Biol 2020 16;8:385. Epub 2020 Jun 16.

Cellular and Molecular Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

One of the challenges in the area of diagnostics of human thyroid cancer is a preoperative diagnosis of thyroid nodules with indeterminate cytology. Herein, we report an untargeted metabolomics analysis to identify circulating thyroid nodule metabolic signatures, to find new novel metabolic biomarkers. Untargeted gas chromatography-quadrupole-mass spectrometry was used to ascertain the specific plasma metabolic changes of thyroid nodule patients, which consisted of papillary thyroid carcinoma (PTC; = 19), and multinodular goiter (MNG; = 16), as compared to healthy subjects ( = 20). Read More

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http://dx.doi.org/10.3389/fcell.2020.00385DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7308550PMC

The change in the clinical presentation of Graves' disease: a 30 years retrospective survey in an academic Brazilian tertiary center.

Arch Endocrinol Metab 2020 Jun 29. Epub 2020 Jun 29.

Endocrinologia e Metabolismo, Hospital da Pontifícia Universidade Católica de Campinas (PUC-Campinas), Campinas,SP, Brasil.

Objective: Graves' disease (GD) is the main cause of hyperthyroidism among adults. It is an autoimmune condition classically marked by the Merserburg Triad (goiter, thyrotoxicosis, and orbitopathy), but the change in presentation of GD over time has rarely been studied. To determine changes in the clinical presentation of patients with GD in the last 30 years. Read More

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http://dx.doi.org/10.20945/2359-3997000000265DOI Listing

A young lady with goiter by Mario Sironi (1885-1961).

J Endocrinol Invest 2020 Jun 28. Epub 2020 Jun 28.

Department of Medicine and Surgery, University of Insubria, Endocrine Unit, ASST dei Sette Laghi, Varese, Italy.

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http://dx.doi.org/10.1007/s40618-020-01345-yDOI Listing

Fluctuations in Moyamoya Vasculopathy Associated with Basedow Disease Depending on Thyroid Hormone Status.

Case Rep Neurol 2020 May-Aug;12(2):140-147. Epub 2020 May 20.

Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

A 31-year-old woman presented with sudden onset of weakness in her left upper limb. Magnetic resonance imaging revealed acute cerebral infarctions in the right frontal and parietal lobes. Magnetic resonance angiography showed stenosis in the proximal portions of the bilateral middle cerebral arteries and terminal portions of the bilateral internal carotid arteries. Read More

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http://dx.doi.org/10.1159/000502571DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7315203PMC

The correlation between ultrasonographic features, bFGF, and the local invasiveness of thyroid papillary carcinoma.

Medicine (Baltimore) 2020 Jun;99(26):e20644

Department of Ultrasound.

The present study aimed to investigate the correlation between ultrasonographic features, basic fibroblast growth factor (bFGF), and the local invasiveness of papillary thyroid carcinoma (PTC).A total of 350 samples of thyroid nodules were collected. Routine ultrasonography was performed before the operation and routine pathological diagnosis and bFGF detection were performed after the operation. Read More

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http://dx.doi.org/10.1097/MD.0000000000020644DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7328907PMC

Amyloid Goiter: A Case Report and Review of the Literature.

Saudi J Med Med Sci 2020 May-Aug;8(2):151-155. Epub 2020 Apr 17.

Clinic for Surgery, University Clinical Centre Tuzla, Faculty of Medicine, University of Tuzla, Tuzla, Bosnia and Herzegovina.

Amyloid goiter is a very rare manifestation of amyloidosis. Here, we describe the case of a 40-year-old male, who presented with upper airway obstructive symptoms including hoarseness and breathing difficulty, to highlight the clinical and pathological features of secondary amyloidosis of the thyroid gland and the difficulties in making a preoperative diagnosis. The patient had previously been wounded in the war in Bosnia, which resulted in the right kidney being surgically removed. Read More

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http://dx.doi.org/10.4103/sjmms.sjmms_308_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7305682PMC

Long-Term Follow-Up and Outcomes of Autoimmune Thyroiditis in Childhood.

Front Endocrinol (Lausanne) 2020 5;11:309. Epub 2020 Jun 5.

Pediatric Endocrine Institute, Ha'Emek Medical Center, Afula, Israel.

Autoimmune thyroiditis (AIT) is the most common cause of acquired hypothyroidism in children. The natural outcome of AIT in childhood has been reported previously however follow-up duration is generally short and results variable. To characterize clinical and biochemical findings at presentation of AIT, evaluate long-term outcomes and assess which factors at presentation predict evolution over time. Read More

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http://dx.doi.org/10.3389/fendo.2020.00309DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7291832PMC

Successful advancement of endotracheal tube with combined fiberoptic bronchoscopy and videolaryngoscopy in a patient with a huge goiter.

SAGE Open Med Case Rep 2020 10;8:2050313X20923232. Epub 2020 Jun 10.

Department of Anesthesiology and Pain Medicine, Anesthesia and Pain Research Institute, Yonsei University College of Medicine, Seoul, South Korea.

If the presence of a goiter causes airway deformities in the supraglottic and infraglottic areas, difficult airway should be considered and airway evaluation including physical examination, radiologic studies, and indirect laryngoscopy should be preoperatively performed to determine the airway management plan. Various methods such as direct laryngoscopy, videolaryngoscopy, awake fiberoptic intubation, tracheostomy, and extracorporeal membrane oxygenation support have been reported to secure the airway. In most previously reported goiter cases, the upper airway patency was well maintained and the endotracheal tube was easily passed even when there was severe tracheal narrowing and deviation. Read More

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http://dx.doi.org/10.1177/2050313X20923232DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7290263PMC

[The thyroid gland in old age : Physiology and pathology].

Wien Med Wochenschr 2020 Jun 22. Epub 2020 Jun 22.

Institut für Nuklearmedizin, Krankenanstalt Rudolfstiftung, Juchgasse 25, 1030, Wien, Österreich.

In healthy older people the metabolism of thyroid hormones is physiologically altered and can possibly even actively contribute to longevity. This should also be taken into consideration in the treatment of diseases of the thyroid and principally also for younger patients. For example, with progressing age comorbidities become more prevalent and especially in cardiovascular diseases, hyperthyroidism is less well tolerated, and should be treated more aggressively. Read More

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http://dx.doi.org/10.1007/s10354-020-00761-2DOI Listing

Surgical management of benign thyroid disease in children.

Semin Pediatr Surg 2020 Jun 16;29(3):150922. Epub 2020 May 16.

Department of Pediatric Surgery, Phoenix Children's Hospital, Phoenix, AZ. Electronic address:

Benign thyroid disease in children represents a wide spectrum of disease. While most benign thyroid disorders may be either monitored or managed medically, surgery is an important treatment, particularly for Graves' disease or large multinodular goiters. Multidisciplinary teams including specialists in pediatric endocrinology, genetics, radiology, pathology and surgery at high volume centers offer the safest and most effective management. Read More

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http://dx.doi.org/10.1016/j.sempedsurg.2020.150922DOI Listing

Thyroid gland changes in patients with acromegaly.

Arch Endocrinol Metab 2020 May-Jun;64(3):269-275

Department of Endocrinology, Medical University, Sofia, Bulgaria.

Objective: Acromegaly is characterized by high neoplastic morbidity as a side effect of growth hormone (GH) hypersecretion. Increased incidence of goiter, thyroid carcinoma, and thyroid dysfunction is also reported. The aim of the present study was to find the prevalence of thyroid dysfunction and goiter in patients with acromegaly and determine its relationship to disease activity, disease duration, and the presence of secondary hypothyroidism. Read More

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http://dx.doi.org/10.20945/2359-3997000000247DOI Listing

Intrathyroid injection of dexamethasone inhibits Th2 cells in Graves' disease.

Arch Endocrinol Metab 2020 May-Jun;64(3):243-250

Department of Endocrinology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.

Objective: Intrathyroid injection of dexamethasone (IID) was used for decrease the relapse rate of hyperthyroidism in the treatment of Graves' disease (GD), but the mechanism is still unclear. We aimed to explore the effect of IID on T help (Th)1/Th2 cells and their chemokine in patients with GD.

Subjects And Methods: A total of 42 patients with GD who were euthyroidism by methimazole were randomly divided into IID group (n = 20) and control group (n = 22). Read More

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http://dx.doi.org/10.20945/2359-3997000000244DOI Listing

Painless thyroiditis in a dupilumab-treated patient.

Endocrinol Diabetes Metab Case Rep 2020 Jun 16;2020. Epub 2020 Jun 16.

Department of Hematology, Aichi Medical University School of Medicine, Nagakute, Japan.

Summary: Dupilumab an inhibitor of the interleukin (IL)-4R-alpha subunit is used for the treatment of allergic diseases. The patient was a 49-year-old man who received dupilumab for the treatment of severe atopic dermatitis. He presented hyperthyroidism with elevated thyroglobulin and anti-thyroid antibody negativity at 4 months after the initiation of therapy. Read More

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http://dx.doi.org/10.1530/EDM-20-0030DOI Listing

Racial disparities in comorbid conditions among patients undergoing thyroidectomy for Graves' disease: An ACS-NSQIP analysis.

Am J Surg 2020 May 21. Epub 2020 May 21.

Department of Surgery, University of Iowa Carver College of Medicine, Iowa City, IA, 200 Hawkins Drive, 1500 JCP, Iowa City, IA, 52242, USA. Electronic address:

Background: Studies indicate that racial disparities exist in the presentation and outcomes of patients undergoing thyroidectomy for cancer and benign disease. We examined the relationship between race, pre-operative characteristics and outcomes in patients undergoing thyroidectomy for GD.

Methods: Patients were identified from the 2013-2016 American College of Surgeons NSQIP database using ICD-9/10 codes consistent with diffuse toxic goiter. Read More

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http://dx.doi.org/10.1016/j.amjsurg.2020.05.023DOI Listing

[Nodular goiter].

Chirurg 2020 Jun 16. Epub 2020 Jun 16.

Klinik für Viszeral‑, Thorax- und Gefäßchirurgie, Universitätsklinikum Marburg, Marburg, Deutschland.

The indications for surgery of benign goiter should be balanced and professional as the prevalence of benign nodular goiter in Germany is high and not all goiters must be surgically treated. Thyroid nodules are detected in up to 76% of healthy people using modern high-resolution ultrasound (US) and only a few of these nodules are malignant or symptomatic. Even today a thorough medical history, detailed examination of the neck region, a qualified US of the thyroid gland, a 99m-technetium scintigraphy and fine needle aspiration help to select patients who will benefit from thyroid surgery. Read More

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http://dx.doi.org/10.1007/s00104-020-01218-3DOI Listing

Macrofollicular variant of papillary thyroid carcinoma with metastasis to femur.

Thyroid Res 2020 13;13:10. Epub 2020 Jun 13.

Department of pathology, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Av. Vasco de Quiroga No. 15. Col: Belisario Dominguez Seccion XVI, Delegacion: Tlalpan, 14080 Ciudad de Mexico, Mexico.

Background: Macrofollicular variant of papillary thyroid carcinoma (MFV-PTC) is a rare subtype with histological features and an indolent clinical course that can be confused with nodular goiter or follicular adenoma. However, on rare occasions it may show more aggressive biological behavior. Only two cases of MFV-PTC with bone metastases have been reported previously. Read More

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http://dx.doi.org/10.1186/s13044-020-00083-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7293128PMC

Effective Preoperative Plasmapheresis Treatment of Severe Hyperthyroidism in a Patient with Giant Toxic Nodular Goiter and Methimazole-Induced Agranulocytosis.

Medicina (Kaunas) 2020 Jun 12;56(6). Epub 2020 Jun 12.

Collegium Medicum, Jan Kochanowski University, IX Wieków Kielc Av.19, 25-319 Kielce, Poland.

Agranulocytosis is a rare but very serious complication of thyrostatic therapy. In severe hyperthyroidism, the removal of circulating thyroid hormones by plasmapheresis may be an effective therapeutic option. This report describes the therapeutic difficulties and successful preoperative treatment with plasmapheresis in a 63-year-old patient admitted to the Endocrinology Clinic with severe hyperthyroidism, during the course of giant toxic nodular goiter and agranulocytosis, which occurred after 2 weeks of taking methimazole. Read More

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http://dx.doi.org/10.3390/medicina56060290DOI Listing

nPAsym: an open-source plugin for ImageJ to quantify nuclear shape asymmetry.

Comput Methods Programs Biomed 2020 May 29;196:105562. Epub 2020 May 29.

Department of Cytology, Bogomoletz Institute of Physiology, Bogomoletz str. 4, 01024, Kyiv, Ukraine. Electronic address:

Background And Objectives: The nucleus is a complex and dynamic organelle enclosing the major part of the cell's genome. A growing body of evidence suggests that changes in the shape of this organelle can influence cell activities. The other way around, altered nuclear shape may be indicative of impaired cell function. Read More

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http://dx.doi.org/10.1016/j.cmpb.2020.105562DOI Listing

and 51 as diagnostic biomarkers for papillary thyroid carcinoma in formalin-fixed paraffin-embedded tissues.

Pharmazie 2020 Jun;75(6):266-270

Department of Endocrinology, the Affiliated People's Hospital of Jiangsu University, Zhenjiang, Jiangsu Province, P. R. China;, Email:

and are important members of the small RNA family, which have been shown to be significantly downregulated in various human tumors and play a key role in the occurrence and development of tumors. However, little is known about their role in endocrine malignancies. This study aimed to investigate the diagnostic value of and levels in formalin-fixed paraffin-embedded tissues of papillary thyroid carcinoma (PTC) patients, as well as the relationship between clinicopathological characteristics and the two miRNAs. Read More

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http://dx.doi.org/10.1691/ph.2020.0335DOI Listing

Knowledge, attitude, and practice of iodized salt use in Al-Riyadh and Al-Ozozab areas, Khartoum, Sudan.

Sudan J Paediatr 2020 ;20(1):26-33

Prince Abdullah Bin Khaled Coeliac Disease Research Chair, King Saud University, Riyadh, Saudi Arabia.

Iodine deficiency and subsequent iodine deficiency disorders have been a longstanding problem in many areas of the world, including Sudan, and still remains as the leading cause of preventable brain damage. According to the Sudan Household Health Survey, in 2006, the consumption of iodized salt in Sudan was 11%, only to deteriorate later on in 2011 to 9.5%. Read More

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http://dx.doi.org/10.24911/SJP.106-1582985547DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7282441PMC
January 2020

The role of micronutrients in thyroid dysfunction.

Sudan J Paediatr 2020 ;20(1):13-19

College of Medicine, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia.

Thyroid hormones are essential for normal growth and development in children. Nutritional factors are closely related to thyroid dysfunction due to deviation from normal physiology of the gland. Iodine, a main constituent of thyroid hormones (T3 and T4), deficiency is one of the commonest causes of hypothyroidism in children and adults, worldwide. Read More

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http://dx.doi.org/10.24911/SJP.106-1587138942DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7282437PMC
January 2020

Giant submandibular sialolipoma masquerading as huge goitre: a case report.

BMC Surg 2020 Jun 11;20(1):130. Epub 2020 Jun 11.

Department of Otorhinolaryngology-Head and Neck Surgery, School of Medical Sciences, Universiti Sains Malaysia, Kota Bharu, Kelantan, Malaysia.

Background: Sialolipoma is a rare tumour which may arise from both major and minor salivary glands and has recently been described as a variant of salivary gland lipomatous lesions.

Case Presentation: We report a 54-year-old male who presented with a 7-year history of large right anterior neck swelling. He was clinically euthyroid and had no compressive or infiltrative symptoms. Read More

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http://dx.doi.org/10.1186/s12893-020-00787-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7291645PMC
June 2020
1.240 Impact Factor

Prolonged endotracheal intubation: a feasible option for tracheomalacia after retrosternal goitre surgery.

Ann Palliat Med 2020 May 25. Epub 2020 May 25.

Department of Thoracic Surgery, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan 250000, China.

Background: Tracheomalacia may be caused by long-standing compression of retrosternal goitre because of destruction of support of tracheal cartilages. Life-threatening airway collapses may occur after surgical removal of goitre. However, available literature on management methods of tracheomalacia is sparse. Read More

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http://dx.doi.org/10.21037/apm-19-552DOI Listing

Production of KRIT1-knockout and KRIT1-knockin Mouse Embryonic Fibroblasts as Cellular Models of CCM Disease.

Methods Mol Biol 2020 ;2152:151-167

CCM Italia Research Network, Torino, Italy.

The development of distinct cellular and animal models has allowed the identification and characterization of molecular mechanisms underlying the pathogenesis of cerebral cavernous malformation (CCM) disease. This is a major cerebrovascular disorder of proven genetic origin, affecting 0.5% of the population. Read More

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http://dx.doi.org/10.1007/978-1-0716-0640-7_12DOI Listing
January 2020

Pleomorphic Adenoma of the Parotid Gland and Ipsilateral Thyroid Incidentaloma: Report of A Rare Case With Review of Literature.

Transl Med UniSa 2020 May 31;22:15-18. Epub 2020 May 31.

Department of Sense Organs, University Sapienza of Rome, Italy.

Background: Pleomorphic adenomas are benign tumors of the salivary glands that mainly affect the lower pole of the superficial lobe of the parotid gland. The term "pleomorphic" refers to the epithelial and connective origin of the mass. The clinical presentation is typically that of asymptomatic swelling which increases in volume. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7265912PMC

Magnitude of iodine deficiency disorder and associated factors in Dawro zone, Southwest Ethiopia; the hidden hunger: a cross-sectional study.

BMC Nutr 2020 8;6:20. Epub 2020 Jun 8.

Department of Nutrition and Dietetics, College of Public Health and Medical Sciences, Jimma University, P.O.Box: 378, Jimma, Ethiopia.

Background: Iodine deficiency disorder (IDD) is continued to be a major public health problem in Ethiopia. The problem is worse but the data is scarce in some pocket areas of the country. This study was aimed to assess the magnitude of IDD and associated factors in southwest Ethiopia by using different biochemical and clinical indicators. Read More

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http://dx.doi.org/10.1186/s40795-020-00345-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7278065PMC

Association between various thyroid gland diseases, TSH values and thyroid cancer: a case-control study.

J Cancer Res Clin Oncol 2020 Jun 9. Epub 2020 Jun 9.

Department of Epidemiology, IQVIA, Unterschweinstiege 2-14, 60549, Frankfurt, Germany.

Background: The goal of this retrospective cohort study was to analyze the association between benign thyroid alteration and thyroid cancer in patients followed in general practices in Germany.

Methods: Patients aged 18-80 who had received an initial diagnosis of thyroid cancer in one of 1261 general practices in Germany between January 2009 and December 2018 were included in this study (index date). These patients were matched (1:1) to non-cancer patients by age, sex, physician and index year. Read More

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http://dx.doi.org/10.1007/s00432-020-03283-xDOI Listing

Familial Mediterranean Fever Complicated by a Triad of Adrenal Crisis: Amyloid Goiter and Cardiac Amyloidosis.

Case Rep Rheumatol 2020 19;2020:7865291. Epub 2020 May 19.

Medicine Department, Ahli Hospital, Hebron, Palestine, Israel.

Background: FMF is a common disease in the Mediterranean populations and may be complicated by AA amyloidosis. The coexistence of adrenal and thyroid amyloidosis in AA amyloidosis secondary to familial Mediterranean fever (FMF) is an extremely rare reported condition. We presented a previously unreported triad of adrenal, thyroid, and cardiac amyloidosis secondary to FMF. Read More

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http://dx.doi.org/10.1155/2020/7865291DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7256690PMC

Concomitant aortic valve replacement and retrosternal goitre resection via mini-sternotomy: a novel case.

J Surg Case Rep 2020 May 1;2020(5):rjaa066. Epub 2020 Jun 1.

Department of Endocrine Surgery, University Hospital of Wales, Cardiff, UK.

Median sternotomy has been used to aide thyroidectomies demonstrating good outcomes; however no cases have been documented to show the use of mini-sternotomy to perform simultaneous thyroidectomy and valve surgery. We present a novel case of an 83-year-old woman with severe aortic stenosis and retrosternal goitre extending to the aortic arch deemed unsuitable for TAVI. Due to co-morbid status and anatomical position preventing routine thyroidectomy, we elected to perform a combined procedure to excise the goitre and perform an aortic valve replacement through a mini-J sternotomy, utilizing 3D-reconstructed imaging to plan our approach. Read More

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http://dx.doi.org/10.1093/jscr/rjaa066DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7263760PMC

Resistance to thyroid hormone due to a novel THRB p.Val349Ala mutation in a Taiwanese boy.

J Formos Med Assoc 2020 Jun 3. Epub 2020 Jun 3.

Department of Pediatrics, National Taiwan University Hospital and National, Taiwan University College of Medicine, Taipei, 100, Taiwan; Graduate Institute of Clinical Medicine, National Taiwan University College of Medicine, Taipei, 100, Taiwan. Electronic address:

Resistance to thyroid hormone (RTH) is a rare congenital disorder characterized by impaired sensitivity of target tissues to thyroid hormone. The disease is mostly caused by heterozygous mutations of thyroid hormone receptor β (THRB) gene. We present a ten-year-old Taiwanese boy with goiter, mood disturbances and attention deficit hyperactivity disorder (ADHD). Read More

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http://dx.doi.org/10.1016/j.jfma.2020.05.035DOI Listing

[Sclerotherapy as an alternative to surgery for recurrent nodular goiter].

Khirurgiia (Mosk) 2020 (5):87-92

Pirogov Russian National Research Medical University of the Ministry of Health of Russia, Moscow, Russia.

Objective: To evaluate the results of treatment of recurrent nodular goiter using sclerotherapy with polidocanol.

Material And Methods: A comparative analysis of sclerotherapy (30 patients) and conventional surgical treatment (17 patients) of recurrent goiter was performed.

Results: Sclerotherapy ensures reduction of nodes (linear dimensions of nodes decreased by 14. Read More

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http://dx.doi.org/10.17116/hirurgia202005187DOI Listing

Endocrine surgery during COVID-19 pandemic: do we need an update of indications in Italy?

Endocrine 2020 06 4;68(3):485-488. Epub 2020 Jun 4.

Division of Endocrine Surgery, "Agostino Gemelli" School of Medicine, University Foundation Polyclinic, Catholic University of the Sacred Heart, Rome, Italy.

The ongoing spread of the coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) poses a significant threat to global health. As the coronavirus outbreak began spreading, hospitals were forced to relocate resources to treat the growing number of COVID-19 patients. As a consequence, doctors across the country canceled tens of thousands of nonurgent surgeries. Read More

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http://dx.doi.org/10.1007/s12020-020-02357-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7270156PMC
June 2020
3.527 Impact Factor

Biochemical pattern of thyroid function test and clinical impression of thyroid disorder in a rural tertiary health institution in Nigeria.

Ann Afr Med 2020 Apr-Jun;19(2):89-94

Department of Medicine, College of Medicine and Health Sciences, Afe Babalola University, AdoEkiti, Federal Teaching Hospital, IdoEkiti Annex, Ekiti State, Nigeria.

Background: Thyroid disorders are one of the most common endocrine disorders seen globally. Diagnostic challenge may arise both clinically and biochemically because of the multiple function of thyroid hormones (THs). Request for thyroid function test (TFT s) may be based on clinical impression that may suggest thyroid dysfunction or obvious symptoms and signs that are diagnostic of hyperthyroidism or hypothyroidism. Read More

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http://dx.doi.org/10.4103/aam.aam_31_19DOI Listing

Nasogastric tube insertion difficulty in a patient with a large goiter: A case report.

J Int Med Res 2020 Jun;48(6):300060520927875

Department of Anesthesiology & Pain Medicine, Soonchunhyang University Hospital Bucheon, Bucheon, Republic of Korea.

Airway management under anesthesia is given special attention in patients who have large goiters. Nasogastric tube insertion may be difficult in intubated patients with large goiters. Several methods have been proposed to facilitate the insertion of nasogastric tubes in patients with endotracheal intubation; however, a standard insertion method has not been established. Read More

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http://dx.doi.org/10.1177/0300060520927875DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7273570PMC

Endoscopic thyroid lobectomy vs Conventional open thyroid lobectomy.

Pak J Med Sci 2020 May-Jun;36(4):831-835

Dr. Sehrish Altaf, Department of Surgery Ward 25, Jinnah Postgraduate Medical Center, Karachi, Pakistan.

Background And Objective: Surgical managements for these suspicious nontoxic swellings requires open conventional method of thyroidectomy by neck incisions that can result in prominent scars and immediate risk usually hemorrhage. However new technological innovations came into practiced that include video assisted minimal invasive endoscopy by axillo-breast approach that gives very promising results with excellent cosmesis. In this study, we compared conventional open surgery with minimal invasive endoscopic techniques and associate various complaints and complications that were encountered in surgery. Read More

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http://dx.doi.org/10.12669/pjms.36.4.1604DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7260891PMC

Fetal goiter identified in a pregnant woman with triiodothyronine-predominant graves' disease: a case report.

BMC Pregnancy Childbirth 2020 Jun 3;20(1):344. Epub 2020 Jun 3.

Department of Obstetrics and Gynecology, Akita University Hospital, 1-1-1 Hondo, Akita, 010-8543, Japan.

Background: Approximately 10% of all Graves' disease cases are triiodothyronine (T3)-predominant. T3-predominance is characterized by higher T3 levels than thyroxine (T4) levels. Thyroid stimulating hormone receptor autoantibody (TRAb) levels are higher in T3-predominant Graves' disease cases than in non-T3-predominant Graves' disease cases. Read More

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http://dx.doi.org/10.1186/s12884-020-03035-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7268772PMC

Predictors of euthyreosis in hyperthyroid patients treated with radioiodine I: a retrospective study.

BMC Endocr Disord 2020 Jun 1;20(1):77. Epub 2020 Jun 1.

Department of Internal Medicine, Endocrinology and Diabetology, Central Clinical Hospital of the Ministry of the Interior, Wołoska 137, 02-507, Warsaw, Poland.

Background: Radioiodine (RAI) treatment for hyperthyroidism is a very common modality, chosen by physicians worldwide. The outcome of the therapy, however, is not always predictable. While rendering a patient hypo- or euthyroid is meant as a therapeutic success, the latter does not require lifelong hormonal supplementation. Read More

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http://dx.doi.org/10.1186/s12902-020-00551-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7268615PMC