37,800 results match your criteria Goiter
Head Neck 2018 Dec 6. Epub 2018 Dec 6.
Division of Head and Neck Oncologic and Endocrine Surgery, Department of Otolaryngology-Head and Neck Surgery, University of California, San Francisco, San Francisco, California.
Background: This study examines the effect of insurance status (as a measure of socioeconomic status) on patient with benign thyroid disease.
Methods: A retrospective review was performed among 60 patients undergoing total thyroidectomy for benign thyroid disease. Univariate and multivariable analyses examined the relationship between insurance status and thyroid volume (sum of the left and right lobe volumes). Read More
Anticancer Res 2018 Dec;38(12):6847-6853
Department of Histology and Embryology, Medical University of Wroclaw, Wroclaw, Poland.
Background/aim: The expression of metallothionein I/II (MT-I/II) was examined in thyroids of Graves' disease (GD) and nodular goiter (NG) patients to determine its role as a potential marker of proliferation and autoimmune inflammation in the thyroid.
Patients And Methods: MT-I/II and Ki-67 antigen expression was studied using immunohistochemistry in 72 GD and 24 NG patients.
Results: MT-I/II expression was noted in the cytoplasm and nuclei of thyrocytes of GD and NG patients. Read More
Pol Arch Intern Med 2018 Dec 5. Epub 2018 Dec 5.
INTRODUCTION Goiter recurrence occurs in a substantial number of patients after thyroid resection. OBJECTIVES We aimed to investigate the prevalence and risk factors of recurrent goiters, influence of goiter recurrence on patient quality of life (QoL) and the efficacy of therapy with radioactive iodine (RAI). PATIENTS AND METHODS This was a case-control study. Read More
Indian J Pediatr 2018 Dec 5. Epub 2018 Dec 5.
Department of Community Medicine, Patna Medical College, Patna, India.
Objectives: To estimate the proportion of households using adequately iodized salt, total goitre rate and intelligence quotient (IQ) and to assess association, if any, between consumption of iodized salt and intelligence quotient of children aged 6-12 y in the selected districts of Bihar.
Methods: Community based cross-sectional study was conducted in three districts of Bihar by using cluster sampling technique.
Results: Consumption of iodized salt was 73. Read More
Eye (Lond) 2018 Dec 4. Epub 2018 Dec 4.
Graves' Orbitopathy Center, Endocrinology, Fondazione IRCCS Cà Granda, Ospedale Maggiore Policlinico and University of Milan, Milan, Italy.
B cells have multiple actions on different phases of an immune reaction, mainly resulting in B and T cell-interaction (help), production of cytokines, regulation of dendritic cells and downregulation of regulatory B cells. The effectiveness of B cell depletion therapy is probably due to blockade of the antigen-presenting function of B cells, occurring very early in the setting of autoimmune reactions. B cells undergo a maturation process from stem cells during which the CD 20 antigen, which is the target of rituximab (RTX), is expressed from the stage of pre-B cells to mature and memory B cells, but not on plasma cells. Read More
Rev Prat 2017 Jun;67(6):663-668
Centre de pathologie et d'imagerie, Paris, France, unité thyroïde et tumeurs endocrines (Pr Leenhardt), groupe hospitalier La Pitié-Salpêtrière, UPMC université Paris-VI, Paris, France.
Management of thyroid nodules. Thyroid nodules are frequent and most of them are benign incidentalomas. Physical examination will search for risk factors of thyroid cancer and should evaluate the presence of local or cosmetic symptoms. Read More
J Matern Fetal Neonatal Med 2018 Dec 4:1-191. Epub 2018 Dec 4.
a Department of Gynecology and Obstetrics , CIC Hôpital Mère-Enfant , Nantes , France.
Introduction: The incidence of fetal goiters is reported to be around 1 per 40 000 births. The risk of complications is first of all obstetric, directly related to goiter size, but it may also affect longer term fetal and child development, depending on whether the goiter is due to hypo- or hyperthyroidism. Management is multidisciplinary, but not yet consensual and not always optimal by either endocrinologists or obstetricians. Read More
Rev Esp Anestesiol Reanim 2018 Nov 30. Epub 2018 Nov 30.
Servicio de Anestesiología y Reanimación, Hospital de Jerez de la Frontera, Jerez de la Frontera (Cádiz), España.
McArdle disease or type V glycogenosis is a rare metabolic myopathy consisting of muscle loss and weakness. These patients have risks associated with anaesthesia. They can present with hypoglycaemia, rhabdomyolysis, acute renal failure, and electrolyte changes. Read More
BMC Cancer 2018 Dec 3;18(1):1199. Epub 2018 Dec 3.
Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Science, Tehran, Iran.
Background: The aim of the present study was to investigate the association between matrix metalloproteinase-9 (MMP-9) expression with BRAF V600E mutation and clinicopathological features, in Iranian papillary thyroid cancer (PTC) patients.
Methods: In total, 90 participants including 60 PTC patients (15 males and 45 females) and 30 individuals with benign multinodular goiter (MNG) (5 males and 25 females) which were confirmed by surgical pathology, were investigated. MMP-9 was evaluated at both mRNA and protein levels, using SYBR-Green Real-Time PCR and enzyme-linked immune sorbent assay (ELISA), respectively. Read More
Lond Med Phys J 1815 Apr;33(194):281-283
Hatton-Garden.
Cochrane Database Syst Rev 2018 Nov 29;11:CD003819. Epub 2018 Nov 29.
Researcher in Systematic Reviews, Georg-Kerschensteiner-Straße 16, Munich, Germany, 81829.
Background: Iodine deficiency is the main cause of potentially preventable mental retardation in childhood, as well as causing goitre and hypothyroidism in people of all ages. It is still prevalent in large parts of the world.
Objectives: To assess the effects of iodine supplementation overall, and of different forms and dosages of iodine supplementation separately, in the prevention of iodine deficiency disorders in children. Read More
Iran J Basic Med Sci 2018 Nov;21(11):1140-1147
Department of Basic Sciences, School of Rehabilitation, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Objectives: As the most prevalent endocrine system malignancy, papillary thyroid carcinoma had a very fast rising incidence in recent years for unknown reasons besides the fact that the current methods in thyroid cancer diagnosis still hold some limitations. Therefore, the aim of this study was to improve the potential molecular markers for diagnosis of benign and malignant thyroid nodules to prevent unnecessary surgeries for benign tumors.
Materials And Methods: In this study, 1H-NMR metabolomics platform was used to seek the discriminating serum metabolites in malignant papillary thyroid carcinoma (PTC) compared to benign multinodular goiter (MNG) and healthy subjects and also to better understand the disease mechanisms using bioinformatics analysis. Read More
Int J Surg 2018 Nov 23;60:210-215. Epub 2018 Nov 23.
Department of General Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China. Electronic address:
Background: The extent of total thyroidectomy in the management of multinodular goiter remains unclear. Compared to primary thyroidectomy, secondary total thyroidectomy is more difficult to perform and carries a significantly higher risk of postoperative complications such as recurrent laryngeal nerve (RLN) palsy or hypoparathyroidism. In this study, we aimed to evaluate the efficacy and safety of intraoperative carbon nanoparticle (CN) mapping in patients undergoing secondary total thyroidectomy. Read More
J Gen Fam Med 2018 Nov 29;19(6):219-220. Epub 2018 Aug 29.
Department of General Internal Medicine Mitoyo General Hospital Kanonji Japan.
This paper details the clinical history and management of a 20-year-old male patient who presented with a 2-year history of a neck swelling which was gradually enlarging during the last 3 months. The tumor was histologically diagnosed as an adenomatous nodule of the thyroid gland. Read More
HNO 2018 Dec;66(12):937-950
Klinik für Hals‑, Nasen‑, Ohrenheilkunde und plastische Operationen, Asklepios Klinik St. Georg, Lohmühlenstraße 5, 20099, Hamburg, Deutschland.
Diseases of the thyroid gland are frequent incidental findings during ultrasound examination of the neck. They affect nearly one third of the normal population. Treatment is not always indicated; however, laboratory diagnostic measures must be initiated to specify the disease. Read More
Endokrynol Pol 2018 Nov 19. Epub 2018 Nov 19.
Objective: A big part of cases of congenital hypothyroidism(CH) in Iran are transient. This study designed to investigate etiology of permanent CH(PCH) by thyroid scintigraphy(TS) and its relationship with the first diagnostic thyrotropin(TSH).
Methods: During twelve years (2005-2017) of CH screening in southwest Iran, all infants referred with the diagnosis of CH were followed until the 3rd birthday that they were reevaluated for serum T4,TSH after 3-4 weeks treatment discontinuation. Read More
Updates Surg 2018 Nov 15. Epub 2018 Nov 15.
Department of Surgical Oncological and Oral Sciences, University of Palermo, Via del Vespro 129, 90127, Palermo, Italy.
The purpose of this study was to edit a renovated thyroidectomy difficulty scale (rTDS) in order to identify underlying thyroid diseases with a longer operative time and higher technical difficulty, also considering preservation of recurrent laryngeal nerve. We developed a renovated scale with a maximum score of 20 points by creating a form in which five variables were considered: vascularity, friability, mobility/fibrosis, gland size and difficulty in preservation of the recurrent laryngeal nerve. Two surgeons separately evaluated each of these. Read More
Endocr Pathol 2018 Nov 16. Epub 2018 Nov 16.
Department of Anatomy, College of Basic Medical Sciences of Jinzhou Medical University, Jinzhou, 121001, Liaoning, China.
Regulatory T cells (Tregs) are immunosuppressive immune cells that play an important role in tumor development. Suppression of Treg function is considered to be an effective strategy for cancer therapy. Glycoprotein A repetitions predominant (GARP) has been found on the surface of activated Tregs. Read More
Cureus 2018 Sep 13;10(9):e3298. Epub 2018 Sep 13.
Neurosurgery, Seattle Science Foundation, Seattle, USA.
Large goiters are less common in the developing world due to the use of iodized salt. However, these are seen occasionally. Herein, we report a case of very large goiter identified in a cadaver. Read More
Zhonghua Yu Fang Yi Xue Za Zhi 2018 Nov;52(11):1190-1192
Institute for Endemic Diseases Control and Prevention, Sichuan Center for Disease Control and Prevention, Chengdu 610041, China.
Cytopathology 2018 Nov 12. Epub 2018 Nov 12.
Surgery, All India Institute of Medical Sciences, New Delhi, Delhi, India.
Dyshormonogenetic goitre, being rare, infrequently reaches the cytopathologist's desk. This letter reports a case of a child with dyshormonogenetic goitre, highlighting its cytological features and common differential diagnosis. Dyshormonogenetic goitre (DG) is a rare cause of congenital hypothyroidism, resulting from lack of enzymes necessary for biosynthesis/ transport of thyroid hormones. Read More
Niger J Clin Pract 2018 Nov;21(11):1450-1453
Department of Surgery, University College Hospital, Ibadan, Nigeria.
Introduction: The pyramidal lobe of the thyroid gland is derived from remnant of the thyroglossal duct. Its presence may be missed clinically; however radiologic and intra-operative findings reveal its presence in up to 50% of cases. The incidence of pyramidal lobe is however not clearly known in Sub-Saharan Africa, particularly in Nigeria. Read More
Surgery 2018 Nov 8. Epub 2018 Nov 8.
Department of Visceral and Endocrine Surgery, CHU Poitiers, Poitiers, France. Electronic address:
Background: Few long-term studies define the appropriate extent of surgery and recurrence rates for unilateral multinodular goiter. We compared the rate and time to reoperation in patients with multinodular goiter who underwent lobectomy to that of patients with benign solitary nodule.
Methods: Retrospective study of a prospective database of all patients who underwent lobectomy for multinodular goiter or solitary nodule from 1991 to 2017. Read More
Medicine (Baltimore) 2018 Oct;97(43):e12938
Department of Neurology, Division of Clinical Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan.
Rationale: Antiepileptic drugs (AEDs) are one of the causative drugs of drug-induced hypothyroidism. In most cases, AED-induced hypothyroidism is subclinical and indicated only by abnormalities of free thyroxine (T4) and/or thyroid-stimulating hormone (TSH) levels. Severe symptomatic hypothyroidism following AEDs is rarely reported in the literature. Read More
Genet Med 2018 Nov 9. Epub 2018 Nov 9.
Department of Obstetrics, Gynecology, & Reproductive Sciences, University of California, San Francisco, CA, USA.
Purpose: Numerous etiologies may lead to nonimmune hydrops fetalis (NIHF), and the underlying cause often remains unclear. We aimed to determine the proportion of NIHF cases in which the etiology was clearly determined in a large, contemporary, and diverse cohort, as well as to describe the etiologies with a focus on genetic causes.
Methods: Retrospective review of NIHF cases between 2015 and 2017 from the five University of California Fetal-Maternal Consortium sites. Read More
Int J Surg Case Rep 2018 Oct 25;53:179-181. Epub 2018 Oct 25.
Department of Medical and Surgical Sciences and Advanced Technologies, G.F. Ingrassia, Catania, Italy.
Introduction: Amyloid goiter is due to the deposition of amyloid in the thyroid, resulting with enlargement of the gland and compressive symptoms.
Case: We herein present a case of a 45-year-old male patient who complained of a big swelling in the neck. Ultrasound showed an enlarged thyroid gland with mediastinal involvement. Read More
J Endocrinol Invest 2018 Nov 8. Epub 2018 Nov 8.
Department of Medical, Surgical and Neurological Sciences, University of Siena, Siena, Italy.
Background: Prolactin may exert immunological effects. Over the years, a higher prevalence of autoimmune thyroid diseases (ATD) has been reported in patients with prolactinomas (PRLs) in areas with sufficient iodine intake.
Purpose: The aim of our study was to evaluate the prevalence of ATD [Graves' disease (GD) and chronic autoimmune thyroiditis (AIT)] in a retrospective cohort of Italian patients with PRLs compared to a sex-matched control group, represented by subjects with non-functioning pituitary adenoma (NFPA) or empty sella (ES). Read More
Surgery 2018 Nov 3. Epub 2018 Nov 3.
Cleveland Clinic Foundation.
Background: Patient-reported outcome measures are being used increasingly to assess disease severity and response to surgery. The purpose of this study was to create and validate a patient-reported outcome measure for symptoms of thyroid enlargement and hyperparathyroidism, 2 conditions where the presence of preoperative symptoms and response to surgery is often questioned.
Methods: A questionnaire reviewing common symptoms was developed from a literature review and expert opinion. Read More
Endocrinol Diabetes Nutr 2018 Nov 1. Epub 2018 Nov 1.
Servicio de Cirugía General y Aparato Digestivo, Hospital Universitario Puerta de Hierro, Majadahonda, Madrid, España.
Background: Permanent hypoparathyroidism is the most common long-term complication after total thyroidectomy, causing significant morbidity and requiring long-term replacement therapy. Our study objective was to assess whether intact parathyroid hormone (iPTH) levels on the first day after total thyroidectomy are a good predictor of permanent hypoparathyroidism.
Patients And Methods: A retrospective observational study of all patients undergoing total thyroidectomy between January 2009 and December 2014. Read More
Can Assoc Radiol J 2018 Nov;69(4):422-429
Department of Otolaryngology-Head and Neck Surgery, University of Ottawa, Ottawa, Ontario, Canada. Electronic address:
Purpose: To determine whether an ultrasonography (US)-defined thyroid volume can accurately predict substernal extension or tracheal narrowing.
Methods: After research ethics approval, we identified patients with thyroid nodules investigated with both US and computed tomography (CT). Reviewers assigned scores for both substernal extension and tracheal compression on CT using pre-established classification systems. Read More
Clin Endocrinol (Oxf) 2018 Nov 1. Epub 2018 Nov 1.
School of Medicine and Public Health, University of Newcastle, Australia.
Objective: Post-thyroidectomy hypocalcaemia is a significant cause of morbidity and prolonged hospitalization, usually due to transient parathyroid gland damage, treated with calcium and vitamin D supplementation. We present a randomized, double-blind placebo-controlled trial of preoperative loading with high-dose cholecalciferol (300,000 units) to reduce post-thyroidectomy hypocalcaemia.
Patients And Measurements: Patients (n=160) presenting for thyroidectomy at tertiary hospitals were randomized 1:1 to cholecalciferol (300,000 IU) or placebo 7 days prior to thyroidectomy. Read More
J Endocrinol Invest 2018 Nov 1. Epub 2018 Nov 1.
Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, No. 81 Meishan Road, Shushan District, Hefei, 230032, Anhui, China.
Purpose: Evidence showed that benign thyroid disease was one of the risk factors for thyroid cancer. However, the results of some studies were inconsistent and were previously meta-analyses of case-control studies. Therefore, we performed a meta-analysis of prospective studies to investigate the relationship between benign thyroid diseases and thyroid cancer risk. Read More
Clin Endocrinol (Oxf) 2018 Oct 31. Epub 2018 Oct 31.
Department of Pathology, Chinese People's Liberation Army (PLA) General Hospital, Beijing, China.
Objective: FOXQ1, a member of the forkhead transcription factor family, plays important parts in cell cycle, apoptosis, metabolism, immunology and tumour genesis. Its expression has been associated with poor clinical prognosis in various tumours. However, the clinical significance of FOXQ1 in papillary thyroid carcinoma (PTC) has not been fully studied. Read More
Thyroid 2018 Oct 30. Epub 2018 Oct 30.
University of Miami School of Medicine, 12235, Medicine , 1120 NW 14th St , Suite 310F , Miami, Florida, United States , 33136-1015 ;
Dyshormonogenic congenital hypothyroidism (CH) generally results from biallelic defects in thyroid hormone synthesis genes. Whole exome sequencing (WES) allows easier identification of multiple gene defects. We present 2 Sudanese families with CH resulting from oligogenic defects identified by WES. Read More
Eur Thyroid J 2018 Oct 3;7(5):272-278. Epub 2018 May 3.
Department of Otorhinolaryngology - Head and Neck Surgery, University of Brescia, Brescia, Italy.
Representations of thyroid swelling, intended as an enlarged anterior neck region, in the artworks of various periods are sporadically reported in the scientific literature, and different intents may be hypothesized. A comprehensive review of the international literature was performed on PubMed, Embase, and ResearchGate with the aim to analyze the modalities of representation of thyroid swelling through the ages by different artistic movements. Thyroid swelling is frequently represented in the artworks of many stylistic periods and seems to be a known condition even by the earliest cultures. Read More
Ann R Coll Surg Engl 2018 Oct 29:e1-e4. Epub 2018 Oct 29.
Department of Endocrine Surgery, National University Hospital , Singapore.
The occurrence of nonrecurrent laryngeal nerve and delayed nerve palsy of the contralateral nerve occurring simultaneously has never been described. A 67-year-old woman underwent reoperative completion thyroidectomy for enlarging thyroid nodules with recurrent hyperthyroidism and obstructive symptoms. Preoperative computed tomography of the neck showed a large compressive goitre with an aberrant right subclavian artery. Read More
J Thyroid Res 2018 2;2018:4057542. Epub 2018 Oct 2.
Department of Endocrine Surgery, Sanjay Gandhi Post Graduate Institute of Medical Sciences (SGPGIMS), Lucknow 226014, India.
Scarless (in the neck) endoscopic thyroidectomy (SET) has evolved into a cosmetically preferred alternative to conventional thyroidectomy (ConT). Recently many of our patients are demanding SET; however their goitres are larger than the recommended size of 4-6 cm. Our aim was to compare the outcomes of ET for small (<6 cm) vs large (≥6 cm) goitres and determine its feasibility in such cases. Read More
Biomed Environ Sci 2018 Sep;31(9):645-653
Institute for Iodine Deficiency Disorders Control, Center for Endemic Disease Control, Chinese Center for Disease Control and Prevention, Harbin Medical University, Harbin 150081, Heilongjiang, China.
Objective: The aim of this study was to evaluate the impact of the revised Chinese National Standard GB26878-2011 'Iodine Content in Edible Salt' on the iodine status among the Chinese population.
Methods: In 2011 and 2014, the probability proportionate to size sampling (PPS) was used in each Chinese province to obtain the representative data. In each sampling unit, school children aged 8-10 years and pregnant women were selected. Read More
Int J Surg Case Rep 2018 Oct 17;53:17-20. Epub 2018 Oct 17.
Department of Surgery, Section of Vascular Surgery and Endovascular Therapy, Instituto Nacional de Ciencias Médicas y Nutricion Salvador Zubirán, Mexico City, Mexico. Electronic address:
Introduction: Carotid body tumors (CBT) are rare neoplasms with relatively; due to their malignant potential, the indicated treatment is surgical resection. There have been described some associations of carotid body tumors with other neoplasms, however, the concomitant presentation of CBT with multinodular goiter is rarely encountered.
Presentation Of Case: We herein present the case of a 43-year old woman with the aforementioned association. Read More
Thyroid 2018 Nov 27. Epub 2018 Nov 27.
3 Department of Internal Medicine, School of Medicine of Ribeirão Preto USP, Ribeirão Preto, Brazil.
Background: In 2007 and 2015, two studies were conducted in Ribeirão Preto, São Paulo, Brazil, on schoolchildren of both sexes attending schools of three different socioeconomic levels (school 1: low; school 2: middle; school 3: high).
Methods: Iodine concentrations were measured in samples of kitchen salt from the home provided by the schoolchildren and in urine samples, and these levels were compared to the thyroid volume by clinical assessment.
Results: In 2007, a marked discrepancy in iodine concentrations was found in salt samples in 300 schoolchildren of both sexes (age range 8-10 years). Read More
J Community Hosp Intern Med Perspect 2018 15;8(5):292-295. Epub 2018 Oct 15.
Lewis Katz School of Medicine at Temple University, Philadelphia, PA, USA.
Hyperthyroidism is associated with increased risk of cardiovascular conditions. We report a case of a 50-year-old woman with no prior cardiac history who presented to the emergency department with shortness of breath, chest pain, lower extremity swelling, and generalized fatigue. She was found to have Graves' Disease (GD) and extensive coronary artery disease (CAD), suggesting the possibility of increased risk of de novo CAD in patients with GD in the absence of other risk factors. Read More
DNA Cell Biol 2018 Nov 23;37(11):932-940. Epub 2018 Oct 23.
1 Department of Endocrinology, Shanghai University of Medicine & Health Sciences Affiliated Zhoupu Hospital , Shanghai, China .
The present study was to explore whether the polymorphisms of FAM167 A-BLK region are associated with the susceptibility to autoimmune thyroid disease (AITD). The second sequencing technology was undertaken for seven tag loci mapping of the FAM167 A-BLK region, namely, rs11250144, rs2618431, rs4840568, rs13277113, rs2248932, rs2736340, and rs922483, in 999 AITD patients, including 624 Graves' disease (GD) and 375 Hashimoto's thyroiditis individuals, and 797 healthy cohorts. In contrast to those in controls, allele C of rs11250144 and allele G of rs2618431 both showed increased frequencies in GD patients. Read More
Clin Epidemiol 2018 10;10:1447-1455. Epub 2018 Oct 10.
Division or Rheumatology, Orthopaedics and Dermatology, School of Medicine, University of Nottingham, Nottingham, UK,
Purpose: To estimate the extent of familial aggregation of type 1 diabetes (T1D) and coaggregation of related chronic diseases and assess the relative contribution of environmental and genetic factors on the risks.
Patients And Methods: This population-based study used the Taiwan National Health Insurance database to reconstruct family structure and identify people with T1D and other chronic diseases between 1999 and 2015. Relative risks (RRs) for T1D and other chronic diseases and heritability of T1D were estimated. Read More
Hematol Rep 2018 Sep 24;10(3):7235. Epub 2018 Sep 24.
Division of Medical Oncology & Hematology.
A 52 year-old male presented with neck pain after undergoing thyroidectomy for a goiter three weeks prior which was complicated by a neck hematoma requiring evacuation. Computed tomography (CT) scan showed a neck hematoma requiring evacuation and he received desmopressin with cessation of bleeding. Coagulation studies were normal. Read More
Pak J Med Sci 2018 Sep-Oct;34(5):1146-1151
Muhammad Areeb Ashfaq, Medical Student, Aga Khan University Hospital, Karachi, Pakistan.
Objective: To determine the outcome of patients receiving radioactive iodine therapy for toxic nodular goiter coming to Aga Khan University Hospital Karachi.
Methods: A total of 89 patients who visited the outpatient department of Aga Khan University Hospital from January 2010 to August 2017 were recruited for the study. Toxic nodular goiter was diagnosed on the basis of having hot nodule on thyroid scan with low TSH and high FT4/T4. Read More
JCI Insight 2018 Oct 18;3(20). Epub 2018 Oct 18.
Metabolic Research Laboratories, Wellcome Trust-Medical Research Council Institute of Metabolic Science, Addenbrooke's Hospital, University of Cambridge, Cambridge, United Kingdom (UK).
Defects in genes mediating thyroid hormone biosynthesis result in dyshormonogenic congenital hypothyroidism (CH). Here, we report homozygous truncating mutations in SLC26A7 in 6 unrelated families with goitrous CH and show that goitrous hypothyroidism also occurs in Slc26a7-null mice. In both species, the gene is expressed predominantly in the thyroid gland, and loss of function is associated with impaired availability of iodine for thyroid hormone synthesis, partially corrected in mice by iodine supplementation. Read More
Front Endocrinol (Lausanne) 2018 1;9:577. Epub 2018 Oct 1.
Endocrinology of Aging Unit, Department of Medicine and Surgery, University of Parma, Azienda Ospedaliero-Universitaria di Parma, Parma, Italy.
Angiosarcoma (AS) of the thyroid is a rare and aggressive tumor. Its incidence is higher in iodine-deficient areas but cases unrelated to endemic goiter have been reported. We describe a case of a 63-year-old Italian man living in a non-iodine-deficient area, with no previous diagnosis of thyroid disease with a history of radiation exposure. Read More
Eur J Endocrinol 2018 Oct 12;179(5):R261-R274. Epub 2018 Oct 12.
Division of Endocrinology, Diabetes, and Metabolism, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
The thionamide antithyroid drugs were discovered in large part following serendipitous observations by a number of investigators in the 1940s who found that sulfhydryl-containing compounds were goitrogenic in animals. This prompted Prof. Edwin B Astwood to pioneer the use of these compounds to treat hyperthyroidism in the early 1940s and to develop the more potent and less toxic drugs that are used today. Read More