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    Fetal neonatal hyperthyroidism: diagnostic and therapeutic approachment.
    Turk Pediatri Ars 2017 Mar 1;52(1):1-9. Epub 2017 Mar 1.
    Department of Pediatrics, Division of Neonatology and Pediatric Endocrinology, Erciyes University School of Medicine, Kayseri, Turkey.
    Fetal and neonatal hyperthyroidism may occur in mothers with Graves' disease. Fetal thyrotoxicosis manifestation is observed with the transition of TSH receptor stimulating antibodies to the fetus from the 17th-20th weeks of pregnancy and with the fetal TSH receptors becoming responsive after 20 weeks. The diagnosis is confirmed by fetal tachycardia, goiter and bone age advancement in pregnancy and maternal treatment is conducted in accordance. Read More

    [Iodine 131 joint radio frequency ablation treatment for child with hyperthyroidism goiter: one case report].
    Zhejiang Da Xue Xue Bao Yi Xue Ban 2017 Jan;46(1):89-91
    Department of Ultrasonography, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China.
    A 12-year-old girl presented with a history of cervical mass, and one week of throat discomfort and dyspnea. Five years ago, the patient was diagnosed as Hashimoto's thyroiditis and hyperthyroidism; she received antithyroid drug treatment, but the result was not satisfactory. B-ultrasonic showed that the size of thyroid gland was 8. Read More

    Transoral thyroidectomy: advantages and limitations.
    J Endocrinol Invest 2017 Apr 21. Epub 2017 Apr 21.
    Minimally Invasive and Endocrine Division, Department of Surgery, Police General Hospital, Bangkok, Thailand.
    In this opinion paper of the Journal of Endocrinological Investigation, leading experts in the field report on their current clinical experience with a novel approach for thyroid gland surgery, namely, "transoral thyroidectomy" (TOT). This feasible and novel surgical procedure does not require visible incisions and is, therefore, a truly scarless surgery. Patients meeting the following criteria can be considered as candidates for TOT: (a) an ultrasonographically (US) estimated thyroid diameter ≤10 cm; (b) US-estimated gland volume ≤45 mL; (c) nodule size ≤50 mm; (d) presence of a benign tumor such as a thyroid cyst or a single- or multi-nodular goiter; (e) Bethesda 3 and/or 4 category and (f) papillary microcarcinoma without the evidence of metastasis. Read More

    Preconception management of thyroid disorders.
    J Pak Med Assoc 2017 Apr;67(4):645-647
    Department of Endocrinology, Bharti Hospital, Karnal, India.
    Thyroid function is closely interlinked with pregnancy. Maternal and foetal outcomes can be improved if optimal thyroid function is achieved, and maintained prior to conception. This needs a systematic approach which includes rational screening, appropriate management, and pragmatic counseling. Read More

    Assessing the status of iodine deficiency disorder (IDD) and associated factors in Wolaita and Dawro Zones School Adolescents, southern Ethiopia.
    BMC Res Notes 2017 Apr 18;10(1):156. Epub 2017 Apr 18.
    College of Health Science and Medicine Wollo University, Dessie, Ethiopia.
    Background: Iodine deficiency is the major preventable cause of irreversible mental retardation in the world. Ethiopia is a country with high prevalence of iodine deficiency disorders which continue to affect a large number of the country's population. The aim of the study was to assess the prevalence of iodine deficiency disorder in Wolaita and Dawuro zones. Read More

    [Acute upper airway obstruction caused by a multinodular goitre after tracheotomy].
    Ugeskr Laeger 2017 Apr;179(14)
    This case report illustrates how a multinodular goitre caused acute airway obstruction in a multitrauma 66-year-old male after tracheotomy. The patient had no symptoms of the goitre before the tracheotomy but developed subglottic airway obstruction at the time of decannulation. He underwent a subacute total thyroidectomy which removed the obstructive symptoms. Read More

    Nuclear morphometry and texture analysis on cytological smears of thyroid neoplasms: a study of 50 cases.
    Malays J Pathol 2017 Apr;39(1):33-37
    Hindu Rao Hospital, Department of Pathology, Malka Ganj, Delhi - 110007, India.
    Background: Fine needle aspiration cytology (FNAC) is a reliable and reproducible diagnostic technique for thyroid lesions with certain limitations. Computed morphometric methods have been introduced with a view to improve the diagnostic yield of thyroid aspirates. However, a review of the existing literature revealed conflicting reports regarding morphometric parameters in thyroid neoplasms. Read More

    Transoral endoscopic thyroidectomy: preliminary experience in Italy.
    Updates Surg 2017 Apr 12. Epub 2017 Apr 12.
    Minimally Invasive and Endocrine Surgery Division, Department of Surgery Police General Hospital, Bangkok, Thailand.
    Transoral endoscopic thyroidectomy vestibular approach (TOETVA) is a feasible novel surgical procedure that does not need visible incisions. We describe our initial experience with TOETVA. We recruited 15 patients who were willing to undergo TOETVA. Read More

    Frequency of nodular goiter and autoimmune thyroid disease and association of these disorders with insulin resistance in polycystic ovary syndrome.
    J Turk Ger Gynecol Assoc 2017 Feb 7. Epub 2017 Feb 7.
    Objective: Polycystic ovary syndrome (PCOS) is a frequent endocrine disease in women. Nodular goiter and autoimmune thyroid disease (AITD) are the endocrinological abnormalities that have high prevalence. The purpose of our study was to detect the prevalence of AITD and nodular goiter in PCOS patients and investigate whether PCOS related hormones and metabolic factors affect these thyroid disorders. Read More

    [Assessment and surgical treatment for 58 substernal goiter].
    Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2017 Mar;52(3):228-230
    Department of Otorhinolaryngology Head and Neck Surgery, Zhongda Hospital, Southeast University, Nanjing 210009, China.
    Objective: To investigate the diagnosis and treatment of substernal goiter. Methods: A total of 58 cases with substernal goiters undergoing surgery between January 2005 and December 2015 were analysed retrospectively. There were 10 males and 48 females and their age ranged from 38 to 82 years with a median age of 58 years. Read More

    What is the care pathway of patients who undergo thyroid surgery in France and its potential pitfalls? A national cohort.
    BMJ Open 2017 Apr 7;7(4):e013589. Epub 2017 Apr 7.
    Caisse Nationale d'Assurance Maladie des Travailleurs Salariés, Paris, France.
    Context: The rate of thyroid cancer is increasing in France, as well as concerns about overdiagnosis and treatment.

    Objectives: To examine the care pathway of patients who undergo thyroid surgery in France and detect potential pitfalls.

    Design: A large observational study based on medical reimbursements, 2009-2011. Read More

    Probable interaction between levothyroxine and ritonavir: Case report and literature review.
    Am J Health Syst Pharm 2017 Apr;74(8):587-592
    Northern Alberta Program, Royal Alexandra Hospital, Edmonton, Canada.
    Purpose: A case of probable interaction of levothyroxine and ritonavir is presented along with a review of the relevant literature and recommendations on clinical management.

    Summary: A 37-year-old woman with human immunodeficiency virus infection who had recently undergone thyroidectomy for a benign multinodular goiter presented to a clinic with hypothyroidism (she was also found to be pregnant), and treatment with levothyroxine 75 μg daily was initiated. While receiving antiretroviral therapy (abacavir-lamivudine and lopinavir-ritonavir) during pregnancy, the patient had persistently elevated serum thyroid-stimulating hormone (TSH) concentrations (up to 125. Read More

    ANNALS EXPRESS: Stimulating TSH receptor autoantibodies immunoassay: analytical evaluation and clinical performance in Graves' Disease.
    Ann Clin Biochem 2017 Jan 1:4563217700655. Epub 2017 Jan 1.
    Catholic University School of Medicine.
    Background: Thyroid stimulating hormone (TSH) receptor (TSHR) autoantibodies (TRAbs) are a heterogeneous group of antibodies (Abs) with different functionality. Among all TRAbs only the stimulating one (S-TRAbs) are considered the pathogenetic marker of Graves' Disease (GD). To date, the methods available for TRAbs testing are based on immunoassays (IMAs) which detect total serum TRAbs or bioassays which are not suitable in clinical practice, even though they discern Abs functionality. Read More

    Management of childhood thyroid nodules: Surgical and endocrinological experience in more than one hundred cases.
    J Clin Res Pediatr Endocrinol 2017 Apr 7. Epub 2017 Apr 7.
    Objective: The management of childhood thyroid nodules is still a big challenge for clinicians. In this study, we aimed to present our surgical and endocrinological experience in more than one hundred cases as a large experience in children.

    Methods: Retrospective analysis of patients admitted with a thyroid nodule between 2006-2014 was performed. Read More

    [A Familial Non Medullary Thyroid Carcinoma (FNMTC) : a clinical and genetic update].
    Rev Med Liege 2016 Dec;71(12):557-561
    Service d'Endocrinologie, CHU de Liège, Site du Sart Tilman, Liège, Belgique.
    The syndrome of Familial Non Medullary Thyroid Carcinoma (FNMTC) includes two or more patients with an isolated non-medullary thyroid cancer (papillary, follicular, anaplastic) within the same family. To diagnose FNMTC, the clinician must exclude a syndromic presentation such as the syndromes of Cowden, Gardner or Werner, and the Carney Complex. Up to now, a hundred families with FNMTC have been genetically studied, including forms with (Ch19p13. Read More

    A Case Report on Multiple Stones in the Thyroid Gland in Association with Sclerosing Thyroiditis: An Unusual Encounter.
    J Clin Diagn Res 2017 Feb 1;11(2):PD01-PD03. Epub 2017 Feb 1.
    Associate Professor and Unit Chief, Department of General Surgery, Rajendra Institute of Medical Sciences , Ranchi, Jharkhand, India .
    Stones are very frequently found in the gallbladder and urinary tract. Rarely the thyroid gland can be a site for stone formation. Few cases of calcification in thyroid gland have been described in the medical literature in association with papillary carcinoma and multinodular goiter. Read More

    Nevi, ambient ultraviolet radiation, and thyroid cancer risk: a French prospective study.
    Epidemiology 2017 Apr 5. Epub 2017 Apr 5.
    1 Université Paris-Saclay, Univ. Paris-Sud, UVSQ, Inserm, CESP, Generations and health, F-94805, Villejuif, France. 2Gustave Roussy, F-94805, Villejuif, France 3Hôpital Bretonneau, CHRU de Tours, Gynécologie-Obstétrique, Tours, France 4MINES ParisTech, PSL-Research University, O.I.E. - Centre Observation, Impacts, Energy, CS10207, F-06904, Sophia Antipolis, France.
    Background: Incidence rates have increased considerably worldwide for both differentiated thyroid cancer and cutaneous melanoma, and two-way associations between these neoplasms have been described. Whether melanoma risk factors are associated with thyroid cancer risk remains unknown.

    Methods: Using Cox regression modeling, we prospectively analyzed the relationship between self-reported pigmentary traits, baseline residential ultraviolet (UV) exposure, and thyroid cancer risk in 86,960 women from the E3N cohort, followed-up over 1990-2008 through biennial questionnaires. Read More

    Increased Chromosomal and Oxidative DNA Damage in Patients with Multinodular Goiter and Their Association with Cancer.
    Int J Endocrinol 2017 8;2017:2907281. Epub 2017 Mar 8.
    Department of Biochemistry, Faculty of Medicine, Erciyes University, Kayseri, Turkey.
    Thyroid nodules are a common clinical problem worldwide. Although thyroid cancer accounts for a small percentage of thyroid nodules, the majority are benign. 8-Hydroxy-2'-deoxyguanosine (8-OHdG) levels are a marker of oxidative stress and play a key role in the initiation and development of a range of diseases and cancer types. Read More

    Cyclic peptides for effective treatment in a long-term model of Graves´ disease and orbitopathy in female mice.
    Endocrinology 2017 Mar 29. Epub 2017 Mar 29.
    Procorde-advanceCOR, Fraunhofer Str. 9a, D 82152 Martinsried, Germany.
    A model for human Graves´ disease in mice was used to compare several novel treatment approaches. The mice received regular adenoviral (Ad) thyroid-stimulating receptor (TSHR) A subunit immunisations (4-weekly injections). Generation of anti-TSHR antibodies, enlarged thyroid sizes (goiter), elevated serum thyroxin levels, retro-orbital fibrosis and cardiac involvement (tachycardia and hypertrophy) were consistently observed during 9 months. Read More

    [Congenital goiter in the neonatal foal. Two case reports].
    Tierarztl Prax Ausg G Grosstiere Nutztiere 2017 Apr 3. Epub 2017 Apr 3.
    Jennifer Nieth, Klinik für Geburtshilfe, Gynäkologie und Andrologie der Groß- und Kleintiere mit Tierärztlicher Ambulanz, Justus-Liebig-Universität Gießen, Frankfurter Straße 106, 35392 Gießen, E-Mail:
    Two cases of an innate hyperplastic goiter in foals as well as the sonographic evaluation of the hyperplastic gland are presented. One foal displayed skeletal deformities in the form of a mandibular prognathism and forelimb contractures in addition to the swollen thyroid gland. Because of a poor prognosis, the animal was euthanized. Read More

    Factors Associated with the Prevalence of Thyroid Nodules and Goiter in Middle-Aged Euthyroid Subjects.
    Int J Endocrinol 2017 5;2017:8401518. Epub 2017 Mar 5.
    Institute of Endocrinology, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania.
    The aim of the present study was to determine associations of thyroid hormone levels and different metabolic parameters and anthropometric measurements with volume of nodular and nonnodular thyroid as well as with prevalence of goiter and thyroid nodules in middle-aged euthyroid subjects. Methods. The study consisted of 317 euthyroid subjects aged 48-49 from the Kaunas Cardiovascular Risk Cohort study. Read More

    Goiter prevalence in school-going children: A cross-sectional study in two border districts of sub-Himalayan Jammu and Kashmir.
    J Family Med Prim Care 2016 Oct-Dec;5(4):825-828
    Department of Community Medicine, Government Medical College, Jammu, Jammu and Kashmir, India.
    Introduction: Iodine deficiency disorder remains one of the major public health problems, despite it being easily preventable. Initially thought as the disorder of Himalayan goiter belt, the disorder has been found to have a pan-India presence. The study was planned with the aim to assess the prevalence of goiter among 6-12 years school-going children and to identify levels of iodine in salt consumed at the household level in the study area. Read More

    Atypical Complications of Graves' Disease: A Case Report and Literature Review.
    Case Rep Endocrinol 2017 28;2017:6087135. Epub 2017 Feb 28.
    Endocrine Department, Hamad Medical Corporation, Doha, P.O. Box 3050, Qatar.
    Graves' disease (GD) may display uncommon manifestations. We report a patient with rare complications of GD and present a comprehensive literature review. A 35-year-old woman presented with a two-week history of dyspnea, palpitations, and edema. Read More

    Endocr Pract 2017 Mar 23. Epub 2017 Mar 23.
    From: Section of Endocrinology, Diabetes, & Nutrition, Boston University School of Medicine.
    Background: Iodine is essential for thyroid hormone synthesis, and iodine deficiency may result in thyroid disorders including goiter and hypothyroidism. Patients on long-term enteral nutrition (EN) or parenteral nutrition (PN) may be at risk for micronutrient deficiencies. The recommended daily allowance for iodine intake is 150 μg for nonpregnant adults. Read More

    Association of iodized salt with goiter prevalence in Chinese populations: a continuity analysis over time.
    Mil Med Res 2017 21;4. Epub 2017 Mar 21.
    Department of Military Medical Geography, College of High Altitude Military Medicine, Third Military Medical University, Chongqing, 400038 China.
    Background: Iodine deficiency disorders (IDD) refer to diseases that are caused by insufficient iodine intake, and the best strategy to prevent IDD is the addition of iodine to dietary salt. Because iodine deficiency is a common cause of goiter, the prevalence as effectively controlled after the implementation of universal salt iodization (USI) in China. However, there is substantial controversy as to whether the incidence of thyroid disorders is related to iodized salt intake. Read More

    Urinary iodine concentration (UIC) could be a promising biomarker for predicting goiter among school-age children: A systematic review and meta-analysis.
    PLoS One 2017 22;12(3):e0174095. Epub 2017 Mar 22.
    School of Basic Medical Science, Beijing University of Chinese Medicine, Beijing, China.
    Objectives: To evaluate whether urinary iodine concentration (UIC) can predict goiter among school-age children, and to assess the association between UIC and goiter prevalence.

    Methods: We searched the MEDLINE, EMBASE, Cochrane Library (Cochrane Database of Systematic Reviews), Web of Science, CNKI, VIP, and Wan Fang databases for relevant reports in both English and Chinese up to August 25, 2016. The mean differences (MD) and 95% confidence intervals (CI) were calculated for the UIC and goiter prevalence assessments. Read More

    Quantification of thyroid cancer and multinodular goiter risk in the DICER1 syndrome: a family-based cohort study.
    J Clin Endocrinol Metab 2017 Feb 2. Epub 2017 Feb 2.
    Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD.
    Context: The risk of thyroid cancer and multinodular goiter (MNG) in the DICER1 syndrome, a rare tumor-predisposition disorder, is unknown.

    Objective: To quantify the risk of thyroid cancer and MNG in individuals with the DICER1 syndrome.

    Design: Family-based cohort study. Read More

    Iodine deficiency: Clinical implications.
    Cleve Clin J Med 2017 Mar;84(3):236-244
    Department of Endocrinology, Diabetes and Metabolism, Cleveland Clinic, Cleveland, OH, USA.
    Iodine is crucial for thyroid hormone synthesis and fetal neurodevelopment. Major dietary sources of iodine in the United States are dairy products and iodized salt. Potential consequences of iodine deficiency are goiter, hypothyroidism, cretinism, and impaired cognitive development. Read More

    Evaluation of platelet indices as a useful marker in papillary thyroid carcinoma.
    Bratisl Lek Listy 2017 ;118(3):153-155
    Objectives: Our aim was to investigate platelets (PLT) and their indices - mean platelet volume (MPV), platelet distribution width (PDW) and plateletcrit (PCT) - in the differential diagnosis of benign and malignant thyroid disorders.

    Background: Platelet and platelet indices recently started to be defined as an useful clinical marker in cancer patients. Their higher reproducibility rates and low cost provide them a wide range of usage. Read More

    Simultaneous induction of Graves' hyperthyroidism and Graves' ophthalmopathy by TSHR genetic immunization in BALB/c mice.
    PLoS One 2017 20;12(3):e0174260. Epub 2017 Mar 20.
    Department of Endocrinology, Jingling Hospital, Medical School of Nanjing University, Nanjing, P.R. China.
    Background: Graves' disease is the most common form of autoimmune thyroid disorder, characterized by hyperthyroidism due to circulating autoantibodies. To address the pathological features and establish a therapeutic approach of this disease, an animal model carrying the phenotype of Graves' disease (GD) in concert with Graves' Ophthalmopathy (GO) will be very important. However, there are no ideal animal models that are currently available. Read More

    Relationship Among Pulmonary Hypertension, Autoimmunity, Thyroid Hormones and Dyspnea in Patients With Hyperthyroidism.
    Am J Med Sci 2017 Apr 1;353(4):374-380. Epub 2017 Feb 1.
    Department of Endocrinology and Metabolism, Faculty of Medicine, Namik Kemal University, Tekirdag, Turkey.
    Objective: Previous studies have reported conflicting results regarding the mechanisms underlying the pathophysiology of pulmonary hypertension (PHT) in patients with hyperthyroidism. Therefore, in this study, we investigated the association between PHT and thyroid-stimulating hormone (TSH) receptor antibody, thyroid peroxidase antibody, thyroglobulin antibody, TSH, fT3, fT4 and dyspnea during daily activities in a large population of patients with hyperthyroidism.

    Methods: A total of 129 consecutive patients with hyperthyroidism, 37 with hypothyroidism and 38 euthyroid controls were enrolled in this study. Read More

    A concise review of Hashimoto thyroiditis (HT) and the importance of iodine, selenium, vitamin D and gluten on the autoimmunity and dietary management of HT patients.Points that need more investigation.
    Hell J Nucl Med 2017 Jan-Apr;20(1):51-56. Epub 2017 Mar 20.
    Department of Internal Medicine, Naval Hospital of Crete, Chania, Greece.
    Hashimoto's thyroiditis (HT) is a chronic autoimmune thyroid disease caused by an interaction between genetic factors and environmental conditions, both of which are yet to be fully understood. The management of HT depends on its clinical manifestations, commonly including diffuse or nodular goiter with euthyroidism, subclinical hypothyroidism and permanent hypothyroidism. However, in most cases of patients with HT, lifelong levothyroxine substitution is required. Read More

    Tuberculous Dactylitis with Concomitant Thyroid Involvement: A Rare Presentation of Childhood Tuberculosis.
    J Coll Physicians Surg Pak 2017 Mar;27(3):S21-S22
    Department of Paediatric Medicine, The Children's Hospital and The Institute of Child Health, Lahore.
    Extrapulmonary tuberculosis rarely presents as thyroid involvement along with other manifestations, and poses a diagnostic challenge on account of paucibacillary nature of disease. In general, the diagnosis of tuberculosis is based on epidemiological risk factors, clinical features, imaging studies, in addition to a positive skin testing or Interferon Gamma Release Assay (IGRA). A 14-year boy presented with history of fever and weight loss for one year. Read More

    Airway Management in Patients with Tracheal Compression Undergoing Thyroidectomy: A Retrospective Analysis.
    Anesth Essays Res 2017 Jan-Mar;11(1):110-116
    Department of Anesthesiology, Government Medical College, Kozhikode, Kerala, India.
    Background: Airway management in large and retrosternal goiters with tracheal compression is often fraught with challenges and is a source of apprehension among anesthesiologists globally.

    Aims: In this study we attempt to delineate the preferred techniques of airway management of such cases in our institution and also to assess whether airway management was unnecessarily complicated.

    Setting And Design: Retrospective analysis. Read More

    [Expression of microRNA-221 and IL-17 in papillary thyroid carcinoma and correlation with clinicopathologic features].
    Zhonghua Bing Li Xue Za Zhi 2017 Mar;46(3):160-165
    Department of Pathology, School of Basic Medical Science, Chongqing Medical University, Chongqing 400016, China.
    Objective: To study the expression of microRNA-221(miR-221) and IL-17 in papillary thyroid carcinoma (PTC) and their roles in the carcinogenesis of PTC. Methods: Real-time RT-PCR, Western blot and immunohistochemistry (IHC) were used to detect the expression of miR-221 and IL-17 in 40 cases of PTC, 20 adjacent normal thyroid tissues and 20 cases of nodular goiter, and the correlation with clinicopathologic features was analyzed. Results: (1)The expression level of miR-221 was significantly higher in PTC compared with nodular goiter and adjacent normal thyroid tissue (P<0. Read More

    Iodine Deficiency and Iodine Prophylaxis in Pregnancy.
    Recent Pat Endocr Metab Immune Drug Discov 2017 Mar 9. Epub 2017 Mar 9.
    Department of Endocrinology, Jagiellonian University Medical College ul. Kopernika 17, 31-501 Krakow. Poland.
    Background: Physiological changes in pregnancy result in increased iodine demand, which may not be met in areas of mild-to-moderate iodine deficiency or borderline sufficiency. As a pregnant woman is the only source of thyroid hormones for her child during early gestation, iodine deficiency-induced hypothyroxinemia may have deleterious effects on fetal development.

    Objective: To present the current approach to iodine deficiency and its prophylaxis during pregnancy. Read More

    Surveys in Areas of High Risk of Iodine Deficiency and Iodine Excess in China, 2012-2014: Current Status and Examination of the Relationship between Urinary Iodine Concentration and Goiter Prevalence in Children Aged 8-10 Years.
    Biomed Environ Sci 2017 02;30(2):88-96
    Institute for Iodine Deficiency Disorders Control, Center for Endemic Disease Control, Chinese Center for Disease Control and Prevention, Harbin Medical University, Harbin 150081, Heilongjiang, China.
    Objective: We aimed to evaluate goiter prevalence and iodine nutritional status in areas with high levels of water iodine; to monitor the prevalence of iodine deficiency disorders (IDD) in areas at high risk of IDD; and to compare the prevalence of goiter and urine iodine (UI) concentrations between children living in the two areas.

    Methods: Based on surveillance from 2012-2014, we analyzed the concentration of UI and prevalence of goiter in 8-10-year-old children from 12 high-risk IDD provinces, and from 8 provinces and municipalities with excessive water iodine. We calculated goiter prevalence for each UI level according to World Health Organization (WHO) standards and constructed predictive prevalence curves. Read More

    [Pyoderma gangrenosum associated with anti-proteinase 3 antineutrophil cytoplasmic antibodies (PR3-ANCA) induced by propylthiouracil].
    Ann Dermatol Venereol 2017 Mar 10. Epub 2017 Mar 10.
    Département de dermatologie, grand hôpital de Charleroi (GHDC), Grand'Rue 3, 6000 Charleroi, Belgique.
    Background: Synthetic antithyroid drugs are often used in the treatment of hyperthyroidism, regardless of aetiology. They may cause various side effects, including the development of anti-neutrophil cytoplasmic antibodies (ANCA), ANCA-associated vasculitis, and neutrophilic dermatoses. Propylthiouracil (PTU) is the antithyroid drug most frequently implicated in ANCA-associated diseases specifically involving anti-myeloperoxidase ANCA (MPO-ANCA). Read More

    [The iodine prophylaxis: the experience in the Autonomous Province of Bolzano (South Tyrol).]
    Recenti Prog Med 2017 Feb;108(2):90-97
    Servizio di Dietetica e Nutrizione Clinica, Comprensorio Sanitario di Bolzano.
    Since ancient times in South Tyrol there was evidence of endemic goitre caused by iodine deficiency. In the early 80's an epidemiological research on adults and primary and secondary school children reported in the least a prevalence of goitre from grade 1 B-3 (WHO) of 23,66% (limits WHO >5%) and an urinary iodine of 10,2 µgI/L. Therefore South Tyrol population presented heavy endemic goitre. Read More

    Effect of excess iodine intake on thyroid diseases in different populations: A systematic review and meta-analyses including observational studies.
    PLoS One 2017 10;12(3):e0173722. Epub 2017 Mar 10.
    Department of Social and Preventive Epidemiology, Graduate School of Medicine, the University of Tokyo, Bunkyo-ku, Tokyo, Japan.
    Background: Although several reports concerning the association of iodine excess and thyroid disease have appeared, no systematic review of the association between iodine excess intake and thyroid diseases, especially hyperthyroidism and hypothyroidism, has yet been reported.

    Method: We conducted a systematic search of Ovid MEDLINE, PubMed, Cochrane Central Register of Controlled Trials databases, Ichushi-Web and CiNii database for intervention trials and observational studies. Search terms were constructed from related words for excess AND iodine intake or excretion AND thyroid hormones or diseases AND study designs. Read More

    MANAGEMENT OF ENDOCRINE DISEASE: Subclinical thyrotoxicosis: prevalence, causes and choice of therapy.
    Eur J Endocrinol 2017 Jun 8;176(6):R325-R337. Epub 2017 Mar 8.
    Department of Endocrinology.
    Subclinical thyrotoxicosis is a condition affecting up to 10% of the population in some studies. We have reviewed literature and identified studies describing prevalences, causes and outcomes of this condition. Treatment should be considered in all subjects if this biochemical abnormality is persistent, especially in case of symptoms of thyrotoxicosis or in the presence of any complication. Read More

    [Genetic analysis of TPO, DUOX2 and DUOXA2 genes in children with permanent congenital hypothyroidism suspected dyshormonogenesis].
    Zhonghua Er Ke Za Zhi 2017 Mar;55(3):210-214
    Department of Guangzhou Newborn Screening Center, Guangzhou Women and Children's Medical Center, Guangzhou 510180, China.
    Objective: To explore the TPO, DUOX2 and DUOXA2 genotypes and phenotypes of children with permanent congenital hypothyroidism(PCH) suspected dyshormonogenesis in Guangzhou, identified and treated at Guangzhou Newborn Screening Center. Six of them were born between 2011 and 2012. Method: Retrospectively analyzed the clinical data of 9 children with PCH suspected dyshormonogenesis. Read More

    Hashimoto's thyroiditis: Relative recurrence risk ratio and implications for screening of first degree relatives.
    Clin Endocrinol (Oxf) 2017 Mar 8. Epub 2017 Mar 8.
    Department of Endocrinology, Seth GSMC and KEM Hospital, Parel, Mumbai, 400091.
    Context: The relative recurrence risk ratio (λR ) for Hashimoto's thyroiditis (HT) has not been widely studied. The age at which thyroid function evaluation should be initiated for relatives of HT patients remains unclear.

    Objective: To study λR and age-related prevalence of HT in first degree relatives of HT patients. Read More

    A Fifteen Year Experience of Total Thyroidectomy for the Management of Simple Multinodular Goitres in a Low Medium Income Country.
    S Afr J Surg 2016 Nov;54(4):40-45
    Department of Surgery, University College Hospital, Ibadan, Nigeria.
    Introduction: Total thyroidectomy as a treatment for simple multinodular goitre is not well recognised in most centres in low middle income countries.

    Method: This paper is a retrospective review of outcomes of total thyroidectomy for simple multinodular goitres in the last fifteen years in a tertiary hospital in Nigeria.

    Results: A total of 652 thyroidectomies were done from January 2001 to December 2015. Read More

    Neglected nontoxic multinodular goiter presented as a large neck mass.
    Clin Case Rep 2017 Mar 20;5(3):357-358. Epub 2016 Dec 20.
    Department of Anatomy-Histology-Embryology University of Ioannina School of Medicine Ioannina Greece.
    Large multinodular goiters, obvious to the naked eye, are rarely confronted by clinicians nowadays; yet they do have a place in the differential diagnosis of the neck masses. Due to the fact that 80% of the neck masses in adults are related to malignancy, the later should be ruled out. Read More

    Incidental 99mTc-HDP Uptake in a Dominant Thyroid Nodule on Bone Scan.
    Clin Nucl Med 2017 May;42(5):386-388
    From the Department of Nuclear Medicine, Concord Repatriation General Hospital, Concord, New South Wales, Australia.
    A 67-year-old woman was referred for a bone scan for evaluation of increasing serum alkaline phosphatase levels. Bone scan revealed no abnormal uptake in the skeleton. However, intense hypervascularity and delayed tracer uptake were incidentally identified in an enlarged right thyroid gland. Read More

    Pituitary Adenoma Recurrence Suspected on Central Hyperthyroidism Despite Empty Sella and Confirmed by 68 Ga-DOTA-TOC PET/CT.
    Clin Nucl Med 2017 Mar 3. Epub 2017 Mar 3.
    From the *Hôpital Tenon, AP-HP, Médecine Nucléaire, Paris; †Université Pierre et Marie Curie, Paris; and ‡Hôpital Saint-Antoine, AP-HP, Endocrinologie, Paris, France.
    Thyrotropin-secreting pituitary adenomas are very rare tumors, known to present overexpression of somatostatin receptor subtype 2 and which may consequently demonstrate abnormal uptake on Ga-DOTA-TOC PET/CT. A 67-year-old woman with a history of operated pituitary macroadenoma presented with symptoms of hyperthyroidism including a large goiter. Her serum thyroid hormone levels were in favor of central hyperthyroidism. Read More

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