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    Socio-demographic characters, distribution and transformation of iodine in soil, plant and wheat grains at District Diamer, Gilgit-Baltistan, Pakistan.
    Environ Geochem Health 2017 Oct 12. Epub 2017 Oct 12.
    Centre for Climate Research and Development (CCRD), COMSATS Institute of Information Technology, Park Road, Chak Shahzad, Islamabad, 45550, Pakistan.
    Iodine deficiency in soils and plants is a common problem in the hilly areas and has still been ignored. The aim of the current study is to investigate associated health issues, socio-economic characteristics and people's perception regarding iodine deficiency. Furthermore, a follow-up study was conducted to determine iodine and nutrients concentration in soil and crops at District Diamer, Gilgit-Baltistan, Pakistan. Read More

    Diagnosis and treatment of TSH-secreting adenomas: review of a longtime experience in a reference center.
    J Endocrinol Invest 2017 Oct 11. Epub 2017 Oct 11.
    Neuroendocrine Unit, Division of Endocrinology and Metabolism, Escola Paulista de Medicina, Universidade Federal de São Paulo, Rua Botucatu, 806, Vila Clementino, São Paulo, CEP 04023-062, Brazil.
    Purpose: TSH-secreting pituitary adenomas are among the less prevalent pituitary tumors, corresponding to 0.9-1.5% of all pituitary adenomas in surgical series. Read More

    Postpartum Follow-up in Women Diagnosed with Subclinical Hypothyroidism during Pregnancy.
    Indian J Endocrinol Metab 2017 Sep-Oct;21(5):699-702
    Department of Endocrinology, Andhra Medical College, Visakhapatnam, Andhra Pradesh, India.
    Background: Management guidelines about the thyroid disease in pregnancy are silent about the postpartum course of new onset subclinical hypothyroidism (SCH). Hence, we analyzed the 2 years outcome of SCH diagnosed during pregnancy.

    Materials And Methods: We conducted this retrospective study using the medical records of patients with new onset SCH during pregnancy between 2010 and 2013 (n = 718). Read More

    Modification of the Surgical Strategy for the Dissection of the Recurrent Laryngeal Nerve Using Continuous Intraoperative Nerve Monitoring.
    World J Surg 2017 Oct 6. Epub 2017 Oct 6.
    Thoracic and Endocrine Surgery, University Hospitals of Geneva, Rue Gabrielle Perret-Gentil 4, 1211, Geneva 14, Switzerland.
    Background: The aim of this study was to describe first experiences and changes in management using continuous intraoperative neuromonitoring (C-IONM) in thyroid and parathyroid surgery.

    Method: Retrospective analysis of patients who underwent surgery with C-IONM since 2012. Surgical maneuvers were modified when electrophysiologic events occurred. Read More

    Predictive Value of Sphingosine Kinase 1 Expression in Papillary Thyroid Carcinoma.
    Anticancer Res 2017 10;37(10):5399-5405
    Department of Pathology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
    Background/aim: Sphingolipid metabolites are emerging as key signaling molecules in cancer. Sphingosine kinase 1 is up-regulated in many different types of human malignancies and plays a crucial role in cancer development and progression. The utility of sphingosine kinase 1 to act as a predictive biomarker in thyroid cancer remains unclear. Read More

    Risk factors for predicting central lymph node metastasis in papillary thyroid microcarcinoma (CN0): a study of 273 resections.
    Eur Rev Med Pharmacol Sci 2017 Oct;21(17):3801-3807
    Department of General Surgery, Nanjing Hospital of Traditional Chinese Medicine, No.3 Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu Province, China.
    Objective: The role of routine central lymph node dissection (CLND) for clinically central lymph node negative (CN0) papillary thyroid microcarcinoma (PTMC) remains uncertain. We aim to determine the predictive factors for central lymph node metastasis (CLNM) in papillary thyroid microcarcinoma.

    Patients And Methods: A total of 273 patients diagnosed with clinically central lymph node negative PTMC from 2014 to 2016 were included. Read More

    Prominent Cold Nodule in Multinodular Goiter Revealed to Be Thyrolipoma: A Case Report.
    Iran J Pathol 2016 24;11(5):456-459. Epub 2016 Dec 24.
    Dept. of Pathology, Rasoul Akram Hospital, Iran University of Medical Sciences, Tehran, Iran.
    The presence of adipose tissue in the thyroid gland is a rare finding. Thyrolipoma or adenolipoma of the thyroid is a benign, encapsulated lesion of the thyroid composed of variable amounts of fat and glandular elements. This report presents a case of thyrolipoma in a 69-yr-old female presenting with neck swelling and respiratory distress. Read More

    Incidence of Hypothyreoidism after Radioactive Iodine-I131 Treatment in Dependance of Hyperthyreoidism Etiology and Therapy Dose.
    Med Arch 2017 Aug;71(4):270-273
    Clinic of Nuclear Medicine and Endocrinology, University Clinical Center Sarajevo, Sarajevo, Bosnia and Herzegovina.
    Introduction: Consensus hasn't been yet achieved about optimal dose quantity that could prevent post therapy hypothyroidism, thus dosing approach varies among different centers. I131 doses can be fixed or calculated, although treatment outcomes don't differ significantly according to recent acknowledgments.

    Aim: Determination of the incidence of hypothyroidism after radioiodine treatment (I131) in dependence of hyperthyroidism etiology and quantity of applied doses. Read More

    Screening Guidelines for Thyroid Function in Children With Alopecia Areata.
    JAMA Dermatol 2017 Sep 27. Epub 2017 Sep 27.
    Section of Pediatric Dermatology, Department of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.
    Importance: The incidence of thyroid disease in children with alopecia areata (AA) has been widely studied with no consensus on whether a true association with AA exists. In addition, screening practices for thyroid dysfunction in children with AA vary widely among clinicians.

    Objective: To reduce health care costs, eliminate unnecessary testing, and standardize clinical practices, we sought to to characterize thyroid function in children with AA to establish guidelines for screening. Read More

    Novel pathogenic variants underlie SLC26A4-related hearing loss in a multiethnic cohort.
    Int J Pediatr Otorhinolaryngol 2017 Oct 8;101:167-171. Epub 2017 Aug 8.
    John P. Hussman Institute for Human Genomics, University of Miami, Miller School of Medicine, Miami, FL, USA; Dr. John T. Macdonald Foundation, Department of Human Genetics, University of Miami, Miller School of Medicine, Miami, FL, USA; Department of Otorhinolaryngology, University of Miami, Miller School of Medicine, Miami, FL, USA. Electronic address:
    Objectives: The genetics of sensorineural hearing loss is characterized by a high degree of heterogeneity. Despite this heterogeneity, DNA variants found within SLC26A4 have been reported to be the second most common contributor after those of GJB2 in many populations.

    Methods: Whole exome sequencing and/or Sanger sequencing of SLC26A4 in 117 individuals with sensorineural hearing loss with or without inner ear anomalies but not with goiter from Turkey, Iran, and Mexico were performed. Read More

    Earliest depiction of vitiligo in "Venus at a Mirror" (1615) by Peter Paul Rubens (1577-1640).
    J Cosmet Dermatol 2017 Sep 27. Epub 2017 Sep 27.
    The Department of Surgery and Cancer, Imperial College London, St Mary's Hospital, London, UK.
    The 1615 painting of Venus at a Mirror by Peter Paul Rubens is considered a powerful example of the Flemish Baroque movement. Recently it has been identified that the Venus character in the image has a goitre, however on studying the image further, I note dermato-pathology in another of the painting's main characters; the dark-skinned female typically described as the Venus' maidservant who clearly demonstrates patches of skin pigment loss on her face and neck with a concurrent streak of white hair. Together these suggest the underlying diagnosis of vitiligo. Read More

    Human SLC26A4/Pendrin STAS domain is a nucleotide-binding protein: Refolding and characterization for structural studies.
    Biochem Biophys Rep 2016 Dec 26;8:184-191. Epub 2016 Aug 26.
    Division of Nephrology and Center for Vascular Biology Research, Beth Israel Deaconess Medical Center, Department of Medicine, Harvard Medical School, Boston, MA 02215, United States.
    Mutations in the human SLC26A4/Pendrin polypeptide (hPDS) cause Pendred Syndrome /DFNB4, syndromic deafness with enlargement of the vestibular aqueduct and low-penetrance goiter. Here we present data on cloning, protein overexpression and purification, refolding, and biophysical characterization of the recombinant hPDS STAS domain lacking its intrinsic variable sequence (STAS-ΔIVS). We report a reproducible protein refolding protocol enabling milligram scale expression and purification of uniformly (15)N- and (13)C(/15)N-enriched hPDS STAS-ΔIVS domain suitable for structural characterization by solution NMR. Read More

    [Value of CT in evaluating the risk of benign and malignant thyroid nodules].
    Zhonghua Yi Xue Za Zhi 2017 Sep;97(35):2766-2769
    Department of Radiology, First People's Hospital of Hangzhou, Hangzhou 310006, China.
    Objective: To evaluate the value of CT in the risk assessment of thyroid benign nodules (BN) and malignant nodules (MN). Methods: The CT signs of 461 pieces of MN in 447 cases and 548 pieces of BN in 484 cases were retrospectively analyzed, the diagnoses were confirmed by histology, including nodular morphology, cookie bite sign, microcalcification, enhanced range narrow/blurred, cystic changes and enhanced.The signs of CT were analyzed by univariate and multivariate regression analysis. Read More

    Neuroleptic malignant syndrome with thyroid disorder: An unusual case report.
    Medicine (Baltimore) 2017 Sep;96(39):e8191
    aDepartment of Internal Medicine, Brookdale University Hospital and Medical Center, Brooklyn bRoss University School of Medicine, Portsmouth, Dominica cDivision of Endocrinology, Brookdale University Hospital and Medical Center, Brooklyn, New York.
    Rationale: Neuroleptic malignant syndrome (NMS) is a life threatening neurologic emergency associated with neuroleptic or antipsychotic agent use. NMS is rarely related to thyroid disease.

    Patient Concerns: We report a case of NMS in a 66-year-old male with past medical history of paranoid schizophrenia on chlorpromazine, diabetes, hypertension and asthma, who presented with a humeral fracture after a fall. Read More

    Intraoperative Monitoring of External Branch of the Superior Laryngeal Nerve: Functional Identification, Motor Integrity, and its Role on Vocal Cord Function.
    J Invest Surg 2017 Sep 27:1-6. Epub 2017 Sep 27.
    b Department of Surgery , Haydarpasa Numune Hospital , Istanbul , Turkey.
    Purpose: Beside recurrent laryngeal nerve (RLN), protection of the external branch of the superior laryngeal nerve (EBSLN) is required for complication-free thyroid surgery. This study investigates the contribution of intraoperative neuromonitoring (IONM) to identification and motor integrity of the EBSLN.

    Methods: This prospective study was performed on 245 EBSLNs in 147 patients with thyroid surgery. Read More

    Sporadic minute medullary thyroid carcinoma with a double RET mutation: A case report.
    Pathol Int 2017 Sep 27. Epub 2017 Sep 27.
    Department of Pathology, Kyorin University School of Medicine, 6-20-2, Shinkawa, Mitaka, Tokyo, 181-8611.
    We describe a 74-year-old man with a nodular goiter accompanied by an incidental sporadic minute medullary thyroid carcinoma (MTC). Histopathologically, the MTC was a well-defined 1.7 mm tumor in the upper one-third right lobe, with solid cell nests (SCNs) adjacent to the MTC. Read More

    Ten-Year Follow-Up of a Randomized Clinical Trial of Total Thyroidectomy Versus Dunhill Operation Versus Bilateral Subtotal Thyroidectomy for Multinodular Non-toxic Goiter.
    World J Surg 2017 Sep 23. Epub 2017 Sep 23.
    Department of Endocrine Surgery, Third Chair of General Surgery, Faculty of Medicine, Jagiellonian University Medical College, 37 Prądnicka Street, 31-202, Kraków, Poland.
    Background: The aim of this study was to validate in a 10-year follow-up the initial outcomes of various thyroid resection methods for multinodular non-toxic goiter (MNG) reported in World J Surg 2010;34:1203-13.

    Materials And Methods: Six hundred consenting patients with MNG were randomized to three groups of 200 patients each: total thyroidectomy (TT), Dunhill operation (DO), bilateral subtotal thyroidectomy (BST). Obligatory follow-up period of 60 months was extended up to 120 months for all the consenting patients. Read More

    Northern Ireland disease surveillance report, April to June 2017.
    • Authors:
    Vet Rec 2017 Sep;181(12):315-318
    Parasitic pneumonia in cowsLeptospirosis in a calfNecrotising mastitis in ewes due to Mannheimia haemolytica infectionCongenital goitre in ovine fetusesActinobacillus pleuropneumoniae pneumonia in growing pigsCircovirus and Salmonella Typhimurium infection in pigeons These are among matters discussed in the Northern Ireland animal disease surveillance quarterly report for April to June 2017. Read More

    Simultaneous unilateral anterior thoracoscopy with transcervical thyroidectomy for the resection of large mediastinal thyroid goiter.
    J Thorac Dis 2017 Aug;9(8):2484-2490
    Division of Otolaryngology, Department of Surgery, Maimonides Medical Center, Brooklyn, NY, USA.
    Background: Almost 25% of thyroid goiters have an intrathoracic component. Although the majority of mediastinal goiters may be approached through a cervical approach, up to a third of substernal goiters require a sternotomy or thoracotomy for resection. As an alternative to conventional sternotomy, we herein describe a combined anterior thoracoscopic and transcervical approach to large mediastinal thyroid goiters. Read More

    Surgical Treatment of Retrosternal Goitre.
    Indian J Otolaryngol Head Neck Surg 2017 Sep 4;69(3):345-350. Epub 2017 Jul 4.
    Department of Thoracic Surgery, The Royal Brompton and Harefield Hospital NHS Foundation Trust, Harefield Hospital, Hill End Road, Harefield, Middlesex, London, UB9 6JH UK.
    This study aims to evaluate surgical approaches to the management of retrosternal goitre. Between 2004 and 2014, 35 patients (eight males; mean age 67.4 ± 10. Read More

    Giant Cervical Goiter With Posterior Mediastinal Extension.
    Cureus 2017 Jul 10;9(7):e1450. Epub 2017 Jul 10.
    MD, Assistant Professor Cardiothoracic Surgery, Al-azhar University, Damitta Branch.
    Most cervico-mediastinal goiters are situated in the anterior mediastinal compartment, but according to the literature, 10-15 percent of them are located in the posterior mediastinum. Although most anterior mediastinal goiters can be removed by using the transcervical approach, cervico-mediastinal goiters in the posterior mediastinal may require additional extracervical incisions. We report the case of a huge cervico-mediastinal goiter extending from the neck retrotracheally to the posterior mediastinum. Read More

    Disseminated tuberculosis presenting as cold abscess of the thyroid gland-a case report.
    Oxf Med Case Reports 2017 Sep 11;2017(9):omx049. Epub 2017 Sep 11.
    Department of Internal Medicine, Christian Medical College, Vellore, India.
    Tubercular involvement of the thyroid gland is a rare entity. Tuberculosis of thyroid gland can present as cold abscess, multinodular goitre, acute abscess or generalized goitre. Clinically, these patients can be euthyroid, hypothyroid or hyperthyroid. Read More

    Incidental Thyroid Carcinoma in Patients Treated Surgically for Presumably Benign Thyroid Disease.
    Mymensingh Med J 2017 Jul;26(3):569-573
    Dr Mohammed Mostafizur Rahman, Associate Professor, Endocrine Surgery, Department of Surgery, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh.
    Incidental Thyroid Carcinoma (ITC) is quite high as been reported in the world's Journal. This study reviews the frequency of the ITC in patients treated surgically for otherwise benign Thyroid disease in one of the Endocrine surgery unit of Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh. This study was developed by the investigating the outcome of one hundred and twenty seven patient who underwent partial or total thyroidectomy for benign thyroid pathology in a single Endocrine Surgery Unit of BSMMU from January 2011 to July 2015. Read More

    Subclinical Hyperthyroidism and the Cardiovascular Disease.
    Horm Metab Res 2017 Oct 15;49(10):723-731. Epub 2017 Sep 15.
    Azienda Ospedaliero-Universitaria di Sassari, Sassari, Italy.
    Thyroid hormone excess has complex metabolic effects, particularly on the cardiovascular system. Treatment of these conditions is universally suggested by international guidelines. Subclinical hyperthyroidism, defined by reduced or suppressed TSH levels in the presence of normal free thyroxine and free triiodothyronine values, is common in the general population and progressively increases with aging, being as high as 15. Read More

    Tracheobronchopathia osteochondroplastica in recurrent retrosternal goiter. Surgical management.
    Ann Ital Chir 2017 Sep 4;6. Epub 2017 Sep 4.
    Tracheobronchopathia osteochondroplastica (TPO) is a rare pathology characterized by a progressive segmentary stenosis of the respiratory tract due to proliferation of osteocartilagineous nodules in the lumen of the distal part of the trachea and large bronchial trunks. Prognosis is usually benign, but some cases with an acute progression and a lethal outcome have been described. Clinical presentation is non specific, the chest x-ray is generally normal and there are not typical radiological signs of suspicion: diagnosis of TPO is usually incidental. Read More

    Tubercular Thyroiditis as a Part of Disseminated Tuberculosis in a Young Male: A Rare Clinical Presentation.
    J Clin Diagn Res 2017 Jul 1;11(7):ED29-ED30. Epub 2017 Jul 1.
    Scientist 'E', Medical Specialist, Department of Thyroid and Endocrine Research, INMAS, DRDO, Timarpur, Delhi, India.
    Thyroid tuberculosis is uncommon even in countries like India where prevalence of tuberculosis is high. Bactericidal actions of colloid, excess iodine stores and high vascularity of the gland have been implicated for the very rare occurrence of thyroid tuberculosis. We present a case of a 16-year-old male with thyroid involvement as a part of disseminated tuberculosis. Read More

    Correlation between serum lead and thyroid diseases: papillary thyroid carcinoma, nodular goiter, and thyroid adenoma.
    Int J Environ Health Res 2017 Oct 11;27(5):409-419. Epub 2017 Sep 11.
    b CAS Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences , Chinese Academy of Sciences , Shanghai , China.
    Studies have showed that lead was associated with human health. However, the effects of lead on thyroid functions are inconsistent, and studies based on Chinese population are fragmentary. To evaluate the correlation between lead and thyroid functions of Chinese with different thyroid diseases, we conducted a hospital-based study. Read More

    Exogenous T3 toxicosis following consumption of a contaminated weight loss supplement.
    Endocrinol Diabetes Metab Case Rep 2017 29;2017. Epub 2017 Aug 29.
    Regional Centre for Endocrinology, Royal Victoria Hospital, BelfastUK.
    A 42-year-old male presented with a one-week history of palpitations and sweating episodes. The only significant history was of longstanding idiopathic dilated cardiomyopathy. Initial ECG demonstrated a sinus tachycardia. Read More

    Multiple Myeloma Presenting as Massive Amyloid Deposition in a Parathyroid Gland Associated with Amyloid Goiter: A Medullary Thyroid Carcinoma Mimic on Intra-operative Frozen Section.
    Head Neck Pathol 2017 Sep 6. Epub 2017 Sep 6.
    Department of Pathology and Immunology, Washington University School of Medicine, 660 S. Euclid Ave., Campus Box 8118, St. Louis, MO, USA.
    Clinical examples of amyloid deposition in parathyroid glands are exceedingly rare and usually present as an incidental finding in a patient with amyloid goiter. Here, we present the first histologically documented case of parathyroid amyloid deposition that presented as a mass. The patient did not have hyperparathyroidism. Read More

    Safety and Outcomes of the Transoral Endoscopic Thyroidectomy Vestibular Approach.
    JAMA Surg 2017 Sep 6. Epub 2017 Sep 6.
    Department of Surgery, University of California, San Francisco.
    Importance: Natural orifice transluminal endoscopic surgery thyroidectomy is a novel approach to avoid surgical scars.

    Objective: To compare the safety and outcomes of the transoral endoscopic thyroidectomy vestibular approach (TOETVA) with those of open thyroidectomy (OT).

    Design, Setting, And Participants: This study retrospectively reviewed all TOETVA and OT operations performed from April 1, 2014, through August 31, 2016, at Police General Hospital, Bangkok, Thailand. Read More

    High prevalence of papillary thyroid carcinoma in nodular Hashimoto's thyroiditis at the first diagnosis and during the follow-up.
    J Endocrinol Invest 2017 Sep 5. Epub 2017 Sep 5.
    Department of Medical Sciences and Public Health, University of Cagliari, Cagliari, Italy.
    Background: The association between Hashimoto's thyroiditis (HT) and papillary thyroid carcinoma (PTC) remains to be elucidated.

    Materials And Methods: A total of 484 HT patients were retrospectively subdivided into two groups: 243 without thyroid nodules, TNs (HTN-) and 241 with TNs (HTN+). Fine-needle aspiration cytology was available in 152 HTN+ patients. Read More

    Impact of pre-operative serum 25-hydroxyvitamin D on post-operative serum calcium in patients undergoing total thyroidectomy for benign goitre: retrospective study of 246 patients.
    J Laryngol Otol 2017 Oct 6;131(10):925-929. Epub 2017 Sep 6.
    Department of ENT and Head and Neck Surgery,University Hospital,Amiens,France.
    Objective: To determine whether pre-operative serum 25-hydroxyvitamin D has an impact on post-operative parathyroid hormone and serum calcium levels in patients undergoing total thyroidectomy for benign goitre.

    Methods: This single-centre, retrospective study comprised 246 unselected surgical patients who had undergone total thyroidectomy for bilateral, benign, multinodular goitre. The correlation between pre-operative serum 25-hydroxyvitamin D and post-operative serum parathyroid hormone and serum calcium was studied to determine whether low pre-operative serum 25-hydroxyvitamin D was predictive of post-operative hypocalcaemia. Read More

    Quality of life after thyroidectomy in patients with nontoxic nodular goiter: A prospective cohort study.
    Head Neck 2017 Sep 4. Epub 2017 Sep 4.
    Department of ORL Head & Neck Surgery, Odense University Hospital, Odense, Denmark.
    Background: Using the thoroughly validated Thyroid-Related Quality-of-Life Patient-Reported Outcome (ThyPRO) questionnaire, the purpose of this study was to investigate changes in disease-specific quality of life (QOL) after surgical treatment in patients with benign nontoxic multinodular goiters.

    Method: Patients with goiters scheduled for thyroid surgery (n = 106) and individuals from the general population (n = 739) were studied. The ThyPRO data before, 3 months, and 6 months after surgery were compared with normative scores from the general population using a linear mixed model and t tests. Read More

    Search for relevant indications for selenium supplementation in thyroid diseases.
    Neuro Endocrinol Lett 2017 Aug 5;38(4):237-241. Epub 2017 Aug 5.
    Polish Mother's Memorial Hospital Research Institute, Lodz, Poland.
    Selenium plays a significant role in the thyroid function and its deficiency is considered by some authors to be a cause of thyroid disorders. The potential therapeutic influence of selenium supplementation in thyroid disease was investigated in several studies and some results were encouraging, however results were inconsistent and did not allow conclusion to be drawn. For that reason, we have performed a review study on relevance of selenium supplementation in thyroid disease. Read More

    Metallothionein Isoform Expression in Benign and Malignant Thyroid Lesions.
    Anticancer Res 2017 09;37(9):5179-5185
    Department of Histology and Embryology, Wroclaw Medical University, Wroclaw, Poland.
    Background: Metallothioneins (MTs) are involved in numerous cell processes such as binding and transport of zinc and copper ions, differentiation, proliferation and apoptosis, therefore contributing to carcinogenesis. Scarce data exist on their expression in benign and malignant lesions of the thyroid.

    Materials And Methods: mRNA expression of functional isoforms of MT genes (MT1A, MT1B, MT1E, MT1F, MT1G, MT1H, MT1X, MT2A, MT4) was studied in 17 nodular goiters (NG), 12 follicular adenomas (FA) and 26 papillary thyroid carcinomas (PTC). Read More

    Soy isoflavones inducing overt hypothyroidism in a patient with chronic lymphocytic thyroiditis: a case report.
    J Med Case Rep 2017 Sep 5;11(1):253. Epub 2017 Sep 5.
    Department of Internal Medicine, Saiyu Soka Hospital, 1-7-22 Matsubara, Soka City, Saitama, 344-0041, Japan.
    Background: Many people have thyroid conditions that make them susceptible to hypothyroidism. If the foods they eat may interfere with the production of thyroid hormone, which can lead to development of serious hypothyroidism. The danger of health drinks should always be noted. Read More

    A Cervical Schwannoma Masquerading as a Thyroid Nodule.
    Eur Thyroid J 2017 Jul 21;6(4):216-220. Epub 2017 Jan 21.
    Division of Endocrinology and Metabolism, Harbor-UCLA Medical Center, Torrance, CA, USA.
    Background: We present a case of a cervical schwannoma, likely originating from the pharyngeal plexus of the vagal nerve. The lesion masqueraded as a thyroid nodule and magnetic resonance imaging (MRI) assisted in preoperative diagnosis. We review the radiographic characteristics of nerve sheath tumors on MRI as well as the diagnostic cytologic stains which can enhance the possibility of a correct preoperative diagnosis. Read More

    Mild thyroid peroxidase deficiency caused by TPO mutations with residual activity: Correlation between clinical phenotypes and enzymatic activity.
    Endocr J 2017 Sep 1. Epub 2017 Sep 1.
    Department of Pediatrics, Keio University School of Medicine, Tokyo 160-8582, Japan.
    Thyroid peroxidase (TPO) deficiency, caused by biallelic TPO mutations, is a well-established genetic form of congenital hypothyroidism (CH). More than 100 patients have been published, and the patients have been diagnosed mostly in the frame of newborn screening (NBS) programs. Correlation between clinical phenotypes and TPO activity remains unclear. Read More

    The current status of robotic transaxillary thyroidectomy in the United States: an experience from two centers.
    Gland Surg 2017 Aug;6(4):380-384
    Division of General, Minimally Invasive and Robotic Surgery, University of Illinois at Chicago, Chicago, IL, USA.
    Background: Few studies exist regarding the state of robotic transaxillary thyroidectomy (RT) and its outcomes at high-volume institutions.

    Methods: Eighty-nine patients underwent RT between January 2009 and September 2015 at two tertiary centers. Data were collected from prospectively-maintained IRB-approved databases. Read More

    Using plasma exchange to successfully manage thyrotoxicosis in a patient with possible antithyroid drug-related thrombotic thrombocytopenic purpura.
    Endocr Regul 2017 Jul;51(3):153-156
    .
    Objective: Thrombotic thrombocytopenic purpura (TTP) is a rare disease characterized by microangiopathic hemolytic anemia, thrombocytopenic purpura, neurologic abnormalities, fever, and renal insufficiency. The association or co-existence of thyrotoxicosis or antithyroid drugs with TTP has not been previously reported. Subject and Results. Read More

    Psychosis Following Carbimazole-induced Acute Alteration of Hyperthyroid Status.
    Indian J Psychol Med 2017 Jul-Aug;39(4):516-518
    Department of Psychiatry, National Institute of Mental Health and Neuro Sciences, Bengaluru, Karnataka, India.
    Abrupt normalization of hyperthyroid state with antithyroid drugs is reported to precipitate psychosis. We report the development of acute psychosis in a 20-year-old woman, following 30 days use of tablet carbimazole 10 mg for hyperthyroidism due to the multinodular goiter. At the time of presentation, she was euthyroid with a resolution of hyperthyroid status both clinically and biochemically. Read More

    Multinodular goiter: A study of malignancy risk in nondominant nodules.
    Ear Nose Throat J 2017 Aug;96(8):336-342
    Department of Otolaryngology-Head and Neck Surgery, National University Hospital, 5 Lower Kent Ridge Rd., Singapore 119074.
    The long-standing belief that multinodular goiters are associated with a lower risk of developing into carcinoma has been challenged by the results of some recent studies. In addition, we have noticed in our practice that a sizable proportion of cancers have been arising from nondominant nodules. We performed a retrospective study of 223 cases to determine (1) the incidence of carcinoma in multinodular goiters that required surgical management in our local, predominantly Asian population and (2) the incidence of carcinoma arising from nondominant nodules. Read More

    Mazabraud syndrome associated with McCune-Albright syndrome: a case report and review of the literature.
    Acta Biomed 2017 Aug 23;88(2):198-200. Epub 2017 Aug 23.
    Gaetano Pini-CTO, Milano.
    Mazabraud syndrome is a very rare benign disorder characterized by the association of monostotic or polyostotic fibrous dysplasia and one or multiple intramuscular myxomas. McCune -Albright syndrome is a rare benign disorder characterized by the association of polyostotic fibrous dysplasia, cafè-au-lait skin pigmentations and endocrine dysfunction, such as precocious puberty, diabetes mellitus, goiter and breast fibroadenomatosis. The association of Mazabraud syndrome and McCune-Albright in the same patient is an anecdotal event. Read More

    Symptomatic Long Pauses and Bradycardia due to Massive Multinodular Goiter.
    Case Rep Cardiol 2017 6;2017:4201942. Epub 2017 Aug 6.
    Department of Medicine, University of Chicago, Chicago, IL, USA.
    Sinus node dysfunction with symptomatic bradycardia or chronotropic incompetence is generally an indication for pacemaker implantation. However, in patients with symptomatic sinus bradycardia, the identification and treatment of underlying pathologies may avoid the need for permanent pacemaker implantation. We present a case of carotid sinus syndrome and severe obstructive sleep apnea due to a massive multinodular goiter in a patient who presented with recurrent sinus pauses and syncope. Read More

    A case of intravascular large B cell lymphoma presenting as nodular goiter.
    Diagn Pathol 2017 Aug 25;12(1):64. Epub 2017 Aug 25.
    Department of Pathology, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, No. 26, Shengli Street, Wuhan City, Hubei Province, 430014, People's Republic of China.
    Background: Intravascular large B-cell lymphoma (IVLBCL) is a subtype of diffuse large B-cell lymphoma (DLBCL) that is rare and highly aggressive and that may progressively involve many organs. CNS (central nervous system), BM (bone marrow) and skin are the most common systems involved. To date, only 2 cases of IVLBCL involving the thyroid have been reported. Read More

    The Value of Preoperative Volumetric Analysis by Computerized Tomography of Retrosternal Goiter to Predict the Need for an Extracervical Approach.
    Balkan Med J 2017 Aug 25. Epub 2017 Aug 25.
    Background: Thyroidectomy can be performed via a cervical incision in most patients with retrosternal goiter.

    Aims: To investigate the correlation between the volume of the mediastinal portion of the thyroid gland and the need for an extra-cervical approach for retrosternal goiter.

    Study Design: Diagnostic accuracy study. Read More

    Chylothorax Associated with Substernal Goiter in Graves' Disease Treated with Radioactive Iodine.
    Int J Endocrinol Metab 2017 Apr 7;15(2):e41787. Epub 2017 Jan 7.
    M.D., Department of Internal Medicine, School of Medicine, Pusan National University, 179 Gudeok-Ro, Seo-Gu, Busan 602-739, South Korea.
    Introduction: We present a rare case of chylothorax associated with an intrathoracic goiter in Graves' disease that was treated with radioactive iodine.

    Case Report: A 23-year-old woman with Graves' disease was referred to our clinic with a pleural effusion, dyspnea, characteristic bilateral proptosis, and a diffuse goiter. The pleural fluid biochemistry was consistent with chylothorax. Read More

    Risk Stratification in Multinodular Goiter: A Retrospective Review of Sonographic Features, Histopathological Results, and Cancer Risk.
    Can Assoc Radiol J 2017 Aug 21. Epub 2017 Aug 21.
    Department of Radiology, Adelaide Meath Incorporating the National Children's Hospital, Tallaght, Ireland.
    Purpose: In the management of thyroid nodules, although the potential for malignancy exists, there is also the potential for overtreatment of subclinical disease. Although the TI-RADS (Thyroid Imaging-Reporting and Data System) system outlines a risk stratification score based on suspicious ultrasound findings, it has not been universally accepted. Many TI-RADS 2 or 3 patients proceed to fine needle aspiration biopsy (FNAB), potentially unnecessarily. Read More

    Successful combined surgical approach of a rare retrotracheal goiter in a patient with anatomical impediments.
    Folia Morphol (Warsz) 2017 Aug 23. Epub 2017 Aug 23.
    2nd Department of Propedeutic Surgery, University of Athens Medical School.
    Diving goiters can descend the cervical region expanding directly into the thoracic cavity. In most cases, diving goiters extend into the anterosuperior compartment, but they may also extend behind the trachea. We herein present a case of a male patient with retrotracheal goiter and history of left thyroid lobectomy and median sternotomy for thoracic aortic aneurysm repair with graft placement. Read More

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