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    Biochemical iodine deficiency in selected schools of aligarh.
    Indian J Public Health 2017 Oct-Dec;61(4):309-311
    Professor, Department of Community Medicine, JN Medical College, AMU, Aligarh, Uttar Pradesh, India.
    The goiter prevalence reflects the iodine deficiency in past while urinary iodine excretion levels (UIEL) gives the current status of iodine nutrition. The study was conducted to assess the status of biochemical iodine deficiency in school children of 1st-5th standard (6-12 years). A total of 907 students of seven schools were included using probability proportional to size method. Read More

    Treatment of Goiter with Traditional Chinese Medicine Regimen Xing Qi Hua Ying Tang: A Clinical Study on 72 Patients with Multinodular and Diffuse Goiter.
    J Altern Complement Med 2017 Dec 7. Epub 2017 Dec 7.
    Department of Endocrinology, Traditional Chinese Medicine Hospital of Shanxi , Xi'an, China .
    Objective: The present work aimed to further explore the therapeutic potential of Xing Qi Hua Ying Tang (XQHYT) by conducting a systemic clinical study in patients with goiter.

    Design: Seventy-two patients with either multinodular or diffuse goiter were enrolled and randomly assigned into treatment group receiving XQHYT (n = 36) and control group receiving Hai Zao Yu Hu Tang (n = 36).

    Location: Traditional Chinese Medicine Hospital of Shanxi. Read More

    Thyroid Dysfunction among Greek Patients with Type 1 and Type 2 Diabetes Mellitus as a Disregarded Comorbidity.
    J Diabetes Res 2017 30;2017:6505814. Epub 2017 Oct 30.
    Diabetes Center, 2nd Department of Internal Medicine, Medical School, National and Kapodistrian University of Athens, Hippokration General Hospital of Athens, Athens, Greece.
    Introduction: The aim of this study was to determine the prevalence of thyroid dysfunction in Greek patients with type 1 (T1DM) and type 2 (T2DM) diabetes mellitus as well as its possible relations to glycaemic control and to diabetic complications.

    Methods: A total of 1015 patients, consecutively followed in the Outpatient Diabetes Center, were studied. Anthropometric and biochemical measurements, occurrence of diabetes complications, and classical comorbidities were assessed. Read More

    The efficacy and safety of high-intensity focused ultrasound ablation of benign thyroid nodules.
    Ultrasonography 2017 Oct 10. Epub 2017 Oct 10.
    Department of Surgery, Queen Mary Hospital, University of Hong Kong, Hong Kong, China.
    High-intensity focused ultrasound (HIFU) is a promising form of thermal ablation of benign thyroid nodules, but evidence supporting its use is scarce. The present review evaluated the efficacy and safety of single-session HIFU treatment of benign thyroid nodules. As reported in the literature, the extent of nodule shrinkage following treatment ranged from 48. Read More

    The diagnostic value of fine needle aspiration in comparison with frozen section in thyroid nodules: A 20-year study.
    Caspian J Intern Med 2017 ;8(4):301-304
    Cancer Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran.
    Background: Fine needle aspiration (FNA) is the most important method in the diagnosis of thyroid nodules before surgery. Recently, the efficiency of FNA in thyroid nodule management has been debatable. On the other hand, intraoperative frozen section (FS) has been used to confirm the diagnosis of FNA and select the proper surgical approach. Read More

    Hemostasis in Overt and Subclinical Hyperthyroidism.
    Int J Endocrinol Metab 2017 Jul 23;15(3):e44157. Epub 2017 Apr 23.
    Endocrine Section, MedStar Washington Hospital Center, Washington, DC, 20010.
    Context: There are contradictory results on the effect of hyperthyroidism on hemostasis. Inadequate population-based studies limited their clinical implications, mainly on the risk of venous thromboembolism (VTE). The present review focuses on hemostatic changes in overt and subclinical hyperthyroidism. Read More

    Hyperthyroid patients without Graves' orbitopathy are not at increased risk of developing glaucoma: a nationwide Danish register-based case-control study.
    Endocrine 2017 Dec 2. Epub 2017 Dec 2.
    Department of Endocrinology and Metabolism, Odense University Hospital, Kløvervænget 6, 5000, Odense, Denmark.
    Purpose: Graves' disease (GD) and toxic nodular goiter (TNG) are associated with various comorbidities. However, it is unclarified whether TNG and GD without orbitopathy are associated with glaucoma.

    Methods: This was a case-control study using record-linkage data from nationwide Danish health registers. Read More

    Neck mass: an obstructive cause of respiratory distress with medical management.
    BMJ Case Rep 2017 Dec 2;2017. Epub 2017 Dec 2.
    Department of Neonatology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India.
    Congenital goitre is a known cause of hypothyroidism in newborn. Congenital goitre can be due to defective synthesis of thyroxine or administration of antithyroid drugs to the mother during pregnancy. In this case report, we report an instance of a preterm male infant with antenatally detected goitre presenting as a neck mass with congenital hypothyroidism. Read More

    The association between irisin and muscle metabolism in different thyroid disorders.
    Clin Endocrinol (Oxf) 2017 Dec 2. Epub 2017 Dec 2.
    Department of Endocrinology, Metabolism and Internal Medicine, Poznań University of Medical Sciences, 49 Przybyszewski St, Poznań, Poland.
    Background: Irisin is a new adipo-myokine, encoded by the FNDC5 gene. Currently, there is a discussion regarding the relation between thyroid function and irisin concentration. This prospective study assesses the influence of thyrometabolic changes on serum irisin concentration in association with altered muscle metabolism. Read More

    [Management of moderate and severe dysthyroid orbitopathy: about 22 cases].
    Pan Afr Med J 2017 7;27:257. Epub 2017 Aug 7.
    Service d'Ophtalmologie, CHU Farhat Hached, Sousse, Tunisie.
    Our study aimed to describe the therapeutic management of moderate and severe dysthyroid orbitopathies and to evaluate the factors associated with optic neuropathy as well as the prognostic factors of poor visual outcome using a statistical analysis. We conducted a retrospective study of 22 patients presenting with moderate to severe dysthyroid orbitopathy in at least one eye and hospitalized in the Department of Ophthalmology at the University Hospital Farhat Hached, Sousse over the period from 1998 to 2015. Therapeutic indications were based on activity and severity criteria of the Eugogo (European Group On Graves' Orbitopathy) as well as on the assessment of prognostic factors of poor visual outcome. Read More

    Familial multinodular goiter and Sertoli-Leydig cell tumors associated with a large intragenic in-frame DICER1 deletion.
    Eur J Endocrinol 2017 Nov 29. Epub 2017 Nov 29.
    W Foulkes, Human Genetics, McGill University, Montreal, Canada
    Objective: Familial multinodular goiter (MNG), with or without ovarian Sertoli-Leydig cell tumor (SLCT), has been linked to DICER1 syndrome. We aimed to search for the presence of a germline DICER1 mutation in a large family with a remarkable history of MNG and SLCT, and to further explore the relevance of the identified mutation.

    Design And Methods: Sanger sequencing, Fluidigm access array and multiplex ligation-dependent probe amplification (MLPA) techniques were used to screen for DICER1 mutations in germline DNA from 16 family members. Read More

    Puzzling thyroid function test.
    BMJ Case Rep 2017 Nov 27;2017. Epub 2017 Nov 27.
    Institute of Metabolic Science, University of Cambridge, Cambridge, UK.
    A 13-½-year-old boy was referred to the Department of Endocrinology as a case of thyrotoxicosis for initiation of antithyroid medication. His chief complaint was a swelling in front of the neck, which was incidentally noted by his mother 2 weeks prior to presentation. He denied any history of symptoms suggestive of hyperthyroidism or ophthalmological involvement. Read More

    Graves' Disease Thyrotoxicosis and Propylthiouracil Related Agranulocytosis Successfully Treated with Therapeutic Plasma Exchange and G-CSF Followed by Total Thyroidectomy.
    Mediterr J Hematol Infect Dis 2017 16;9(1):e2017058. Epub 2017 Oct 16.
    Division of Hematology, University Hospital-Santa Maria Misericordia, Udine, Italy.
    Antithyroid drugs can be a rare cause of agranulocytosis (0.5% of treated patients). Suspension of these drugs is mandatory in these patients and may result in worsening hyperthyroidism. Read More

    Prevalence of Goiter and Associated Factors among School Children, Northeast Ethiopia.
    Epidemiol Health 2017 Nov 25. Epub 2017 Nov 25.
    Department of Epidemiology and Biostatistics, Institute of Public Health, University of Gondar, Gondar, Ethiopia.
    Purpose: Goiter is a major public health problem, especially in developing countries like Ethiopia. Hence, this study aimed to assess the prevalence and associated factors of goiter among children in Waghimra Zone, Northeast Ethiopia.

    Methods: A cross-sectional study was conducted from April 8 - 25/2015 in Northeast Ethiopia. Read More

    KRIT1 loss-of-function induces a chronic Nrf2-mediated adaptive homeostasis that sensitizes cells to oxidative stress: implication for Cerebral Cavernous Malformation disease.
    Free Radic Biol Med 2017 Nov 20. Epub 2017 Nov 20.
    Department of Clinical and Biological Sciences, University of Torino, Italy; CCM Italia research network. Electronic address:
    KRIT1 (CCM1) is a disease gene responsible for Cerebral Cavernous Malformations (CCM), a major cerebrovascular disease of proven genetic origin affecting 0.3-0.5% of the population. Read More

    Predictors of a follicular nodule (Thy3) outcome of thyroid fine needle aspiration cytology among Saudi patients.
    BMC Res Notes 2017 Nov 23;10(1):612. Epub 2017 Nov 23.
    Faculty of Medicine, Al-Neelain University, Khartoum, Sudan.
    Objective: A retrospective study was performed to evaluate predictors of thyroid fine needle aspiration cytology (FNAC) outcomes among Saudis with a thyroid nodule. Socio-demographic data, thyroid function status, thyroid parameters, ultrasound and cytology results were collected from 269 files of patients with thyroid nodules.

    Result: The patients' age was 40 ± 1. Read More

    Measurement of Basal Serum Calcitonin for the Diagnosis of Medullary Thyroid Cancer.
    Horm Metab Res 2017 Nov 23. Epub 2017 Nov 23.
    Division for Specific Endocrinology, Medical Faculty, University Hospital Duesseldorf, Duesseldorf, Germany.
    Calcitonin (CT), a tumor marker for medullary thyroid cancer (MTC), can be stimulated with pentagastrin or calcium. Because of the unavailability of pentagastrin, basal CT measurement is frequently used for the preoperative diagnosis of MTC. The aim of the study was to define basal serum calcitonin (bCT) cut-off thresholds for diagnosing MTC. Read More

    High Urinary Iodine, Thyroid Autoantibodies, and Thyroid-Stimulating Hormone for Papillary Thyroid Cancer Risk.
    Biol Trace Elem Res 2017 Nov 21. Epub 2017 Nov 21.
    Department of Breast and Thyroid Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
    Thyroid nodules have become a common clinical problem, and the clinical importance of thyroid nodules lies in the determination of thyroid cancer. This study aims to evaluate the risk factors for papillary thyroid cancer (PTC) with regard to urinary iodine concentration (UIC), thyroid-stimulating hormone (TSH), thyroid peroxidase antibody (TPOAb), and thyroglobulin antibody (TGAb) in comparison to thyroid nodular goiter (NG). Among the 2041 patients, 43. Read More

    Expression of cancer/testis antigens MAGE-A, MAGE-C1, GAGE and CTAG1B in benign and malignant thyroid diseases.
    Oncol Lett 2017 Dec 26;14(6):6485-6496. Epub 2017 Sep 26.
    Division of Pathology Diagnostic Services, Cytology, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA.
    Despite considerable advances in the understanding of thyroid gland biology, correctly diagnosing thyroid nodules and treating high-grade thyroid carcinoma remains challenging. Cancer/testis (CT) antigens have emerged as potential diagnostic tools as well as targets of potential cancer vaccinations. In the present study, a total of 117 patients who underwent surgical therapy for thyroid disease were available for analysis. Read More

    Toxic Adenoma in a Patient with Thyroid Hemiagenesis.
    Cureus 2017 Sep 17;9(9):e1695. Epub 2017 Sep 17.
    Department of Surgery, Duzce University Medical Faculty.
    Thyroid hemiagenesis (TH) is a rare congenital anomaly that is usually asymptomatic. Functional disorders of the thyroid make the patient symptomatic. TH is usually and incidentally established during evaluation of patients with symptomatic thyroid pathology. Read More

    Trans-cervical resection of a separate substernal goitre.
    Int J Surg Case Rep 2017 Nov 10;41:373-376. Epub 2017 Nov 10.
    Department of Surgery, The Northern Hospital, 185 Cooper St, Epping, Victoria, 3076, Australia.
    Introduction: A separate substernal goitre which is not continuous with the main cervical thyroid proves a unique challenge for resection. A trans-cervical approach is preferred but may be hazardous due to the possibility of ectopic thyroid tissue with alternate blood supply.

    Presentation Of Case: A 72year old female who had a previous left hemithyroidectomy presents with a symptomatic central substernal thyroid mass. Read More

    Four synchronous primary cancers of the aerodigestive tract and thyroid.
    Asian Cardiovasc Thorac Ann 2017 Nov 19;25(9):645-648. Epub 2017 Nov 19.
    Department of Thoracic Surgery, 12570 Xiangya Hospital of Central South University , Changsha, Hunan, China.
    We report the case of a 60-year-old man with 4 concurrent primary cancers: thyroid papillary carcinoma, esophageal squamous cell carcinoma, lung adenocarcinoma, gastric stromal tumor, and nodular goiter. A minimally invasive McKeown esophagectomy with 3-field lymph node resection played a major role in the diagnosis and resection of all primary tumors in the same sitting. Multiorgan primary cancers are not uncommon but pose challenges in diagnosis and treatment. Read More

    HBME-1 expression in differentiated thyroid carcinoma and its correlation with the ultrasonic manifestation of thyroid.
    Oncol Lett 2017 Dec 15;14(6):6505-6510. Epub 2017 Sep 15.
    Longnan Hospital of Daqing City, Daqing, Heilongjiang 163453, P.R. China.
    We investigated expression of the protein human bone marrow endothelial cell marker-1 (HBME-1) in differentiated thyroid carcinoma tissues, and analyzed its correlation with ultrasonic manifestation of thyroid. The immunohistochemistry (IHC) staining method was used to measure the expression of HBME-1 in patient with nodular goiter (control group), papillary differentiated thyroid carcinoma (papillary carcinoma group) and follicular differentiated thyroid carcinoma (follicular carcinoma group) to investigate the differences in expression of HBME-1. We further analyzed the correlation of the expression of HBME-1 in the papillary carcinoma group and the follicular carcinoma group with ultrasonic manifestation of thyroid. Read More

    Thyroid malignancy risk in different clinical thyroid diseases
    Turk J Med Sci 2017 11 13;47(5):1509-1519. Epub 2017 Nov 13.
    Background/aim: To evaluate the malignancy risk of thyroid nodules in different clinical thyroid diseases. Materials and methods: Patients who underwent thyroidectomy between 2007 and 2014 were grouped as euthyroid, hypothyroid, and hyperthyroid. Further classification was made depending on the presence of solitary/multiple thyroid nodules. Read More

    Two-stage thyroidectomy in the era of intraoperative neuromonitoring.
    Gland Surg 2017 Oct;6(5):453-463
    Department of Endocrine Surgery, Central Clinic of Athens, Athens, Greece.
    Background: The use of intraoperative neuromonitoring (IONM) provides surgeons with real time information about recurrent laryngeal nerves (RLN) functional integrity. Hence, allowing them to modify the initially scheduled bilateral procedure, to a two-stage thyroidectomy in cases of loss of signal (LOS) on the first side of resection resulting in minimization of bilateral RLN injury. The purpose of our study was to present our results since the implementation of the above mentioned process in both malignant and benign thyroid disease. Read More

    Relationship between metabolic syndrome and nodular thyroid diseases.
    Scand J Clin Lab Invest 2017 Nov 16:1-5. Epub 2017 Nov 16.
    a Faculty of Medicine, Internal Medicine Department , Duzce University , Duzce , Turkey.
    Nodular thyroid diseases are common in Turkey. Insulin resistance (IR) is considered as the most important component of metabolic syndrome (MetS), and it is thought to directly affect thyroid diseases, together with other components of MetS. The aim of this study was to evaluate potential factors associated with thyroid nodularity. Read More

    [Hyperthyroidism in children at the University Hospital in Dakar (Senegal)].
    Pan Afr Med J 2017 7;28:10. Epub 2017 Sep 7.
    Clinique Médicale II/Centre Hospitalier Abass Ndao/UCAD, Dakar, Sénégal.
    Introduction: Hyperthyroidism in children is rare and constitutes a problem because of its psychosomatic impact. This study aimed to present an overview of the state of knowledge on these aspects in children from Dakar.

    Methods: We conducted a multicenter, descriptive study over a period of 15 years. Read More

    PATZ1 knockdown enhances malignant phenotype in thyroid epithelial follicular cells and thyroid cancer cells.
    Oncotarget 2017 Oct 2;8(47):82754-82772. Epub 2017 Aug 2.
    Division of Breast, Endocrine and Respiratory Surgery, Department of Surgery (II), Shinshu University School of Medicine, Matsumoto, Japan.
    This study was designed to examine the involvement of PATZ1 in carcinogenesis and dedifferentiation of thyroid cancer. Immunohistochemistry on clinical specimens indicated nuclear PATZ1 expression in all normal thyroid glands and adenomatous goiter, while nuclear PATZ1 expression decreased along with the dedifferentiation of thyroid cancer. Knockdown of nuclear PATZ1 by siRNA in an immortalized normal follicular epithelial cell line (Nthy-ori 3-1) altered cellular morphology and significantly increased cell proliferation, migration, and invasion. Read More

    Graves disease following radioiodine therapy for toxic adenoma: Clinical case report.
    Medicine (Baltimore) 2017 Nov;96(45):e8550
    Department of Nuclear Medicine, West China Hospital of Sichuan University, Chengdu, Sichuan, People's Republic of China.
    Rationale: There is a low risk of developing Graves disease (GD) with elevated thyrotropin receptor antibodies (TRAbs) in patients undergoing radioiodine therapy for toxic adenoma.

    Patient Concerns: An old female patient with a history of Hashimoto thyroiditis was referred to our department due to thyrotoxic symptoms. After the administration of radioiodine, a significant remission was achieved. Read More

    Papillary Thyroid Cancer and Coexisting Autoimmune Thyroiditis.
    Horm Metab Res 2017 Nov 14;49(11):869-872. Epub 2017 Nov 14.
    Endocrine and Nuclear Medicine Center Tegernsee, Tegernsee, Germany.
    Histological findings often display an association between papillary thyroid carcinomas (PTC) and autoimmune thyroiditis (AIT) and so differ significantly from follicular thyroid carcinomas (FTC). The aim of this interdisciplinary, retrospective study was to evaluate the association of AIT in patients with PTC and FTC and a control group of benign nodular goiters. One hundred thyroidectomies with histologically confirmed differentiated thyroid carcinomas, 67 with PTC and 33 with FTC, were submitted for examination. Read More

    Expression level and clinical significance of IL-2, IL-6 and TGF-β in elderly patients with goiter and hyperthyroidism.
    Eur Rev Med Pharmacol Sci 2017 Oct;21(20):4680-4686
    Department of Endocrinology, People's Hospital of Zhengzhou University, Henan Provincial People's Hospital, Zhengzhou, Henan, China.
    Objective: To investigate the level of expression and the clinical significance of IL-2 (interleukin-2), IL-6 (interleukin-6) and TGF-β (transforming growth factor-β) in elderly patients with goiter and hyperthyroidism.

    Patients And Methods: Gender, age, course of disease, BMI (Body Mass Index), serum FT3 (Free triiodothyronine-3), FT4 (Free triiodothyronine-4), TT3 (Total triiodothyronine-3), TT4 (Total triiodothyronine-4), TSH (Thyroid Stimulating Hormone) and clinical manifestations on admission and other general clinical data and laboratory examination results were collected and statistically analyzed as case group in 128 elderly patients with goiter and hyperthyroidism. Additional 128 over 60-year-old patients with hyperthyroidism were selected as control group. Read More

    Autoimmune Thyroiditis: A Case Control Study on a Sample of Egyptian Type I Diabetic Patients.
    Egypt J Immunol 2017 Jan;24(1):119-130
    National Institute of Diabetes & Endocrinology, Cairo, Egypt.
    Type 1 diabetic patients are vulnerable for autoimmune thyroid disease. The incidence of type I Diabetes in Egypt is 8/100000. Undiagnosed thyroid dysfunction impairs metabolic status and increase cardiovascular risks in diabetic patients. Read More

    Regulation of thyroid sodium-iodide symporter in different stages of goiter: possible involvement of ROS.
    Clin Exp Pharmacol Physiol 2017 Nov 7. Epub 2017 Nov 7.
    Laboratório de Fisiologia Endócrina Doris Rosenthal, IBCCF, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
    Na+ /I- symporter (NIS) transports iodide into thyrocytes, a fundamental step for thyroid hormone biosynthesis. Our aim was to evaluate NIS regulation in different status of goitrogenesis and its underlying mechanisms. Wistar rats were treated with methimazole (MMI) for 5 and 21 days, to achieve different status of goiter. Read More

    Sonographic Features of Cervical Lymph Nodes in Patients With Hashimoto Thyroiditis and the Impacts From the Levothyroxine With Prednisone Therapy.
    Ultrasound Q 2017 Nov 6. Epub 2017 Nov 6.
    *Department of Ultrasound, The Second Affiliated Hospital of Fujian Medical University; and †Department of Clinical Medicine, Quanzhou Medical College, Quanzhou, Fujian, China.
    Objective: This study aimed to evaluate the ultrasonographic pattern of cervical lymph nodes (CLNs) and whether levothyroxine with prednisone therapy is effective for lymphadenopathy in patients with Hashimoto thyroiditis (HT).

    Methods: This retrospective study was looking at patients with confirmed diagnosis of HT who underwent comprehensive neck ultrasound examination. We reviewed sonographic findings in 127 patients with HT, 234 euthyroid patients with goiter, and 122 healthy subjects. Read More

    Molecular Testing for Oncogenic Gene Alterations in Pediatric Thyroid Lesions.
    Thyroid 2017 Nov 6. Epub 2017 Nov 6.
    The Children's Hospital of Philadelphia, Division of Endocrinology and Diabetes, Philadelphia, Pennsylvania, United States.
    Background: Thyroid nodules are less common in pediatric patients (≤18 years) than in adults. The Bethesda System for Reporting Thyroid Cytopathology allows for individual risk stratification, but a significant number of nodules are indeterminate. Incorporating gene mutation panels and gene expression classifiers may aid in pre-operative diagnosis. Read More

    Functional Abnormalities and Thyroid Nodules in Patients with End-stage Renal Disease.
    In Vivo 2017 Nov-Dec;31(6):1203-1208
    Department of Experimental Diagnostic and Specialty Medicine (DIMES), Nephrology, Dialysis and Renal Transplant Unit, S. Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy
    Background/aim: Clinical and subclinical hypothyroidism is more common in patients with end-stage renal disease (ESRD) than in the general population. Patients with ESRD with hypothyroidism are more susceptible to cardiovascular disease, with an increased risk of mortality than those with normal thyroid function. Moreover, these patients have higher incidence of benign and malignant nodules. Read More

    Evaluation of the thyroid nodule with high-resolution ultrasonography and elastography without fine needle aspiration biopsy.
    Med Clin (Barc) 2017 Oct 30. Epub 2017 Oct 30.
    Departamento de Cirugía, Pediatría y Obstetricia y Ginecología, Universidad de Murcia, Murcia, España; Servicio de Cirugía General y de Aparato Digestivo, Hospital Clínico Universitario Virgen de la Arrixaca, Servicio Murciano de Salud, El Palmar, Murcia, España; Instituto Murciano de Investigación Biosanitaria Virgen de la Arrixaca (IMIB-Arrixaca), Murcia, España.
    Introduction: Fine needle aspiration biopsy (FNAB) is the gold standard screening technique used in the diagnostic protocol for thyroid nodules. However, it is not free of complications.

    Objective: To identify thyroid nodules in which FNAB could be avoided during the diagnostic process by means of the use of a high-resolution ultrasonography or elastography. Read More

    Double-Blind, Placebo-Controlled, Randomized Trial of Selenium in Graves Hyperthyroidism.
    J Clin Endocrinol Metab 2017 Nov;102(11):4333-4341
    Institute for Experimental Endocrinology, Charité-Universitätsmedizin Berlin, 13353 Berlin, Germany.
    Context: Supplemental selenium (Se) may affect the clinical course of Graves disease (GD).

    Objective: Evaluate efficacy of add-on Se on medical treatment in GD.

    Design: Double-blind, placebo-controlled, randomized supplementation trial. Read More

    GLIS3 is indispensable for TSH/TSHR-dependent thyroid hormone biosynthesis and follicular cell proliferation.
    J Clin Invest 2017 Oct 30. Epub 2017 Oct 30.
    Immunity, Inflammation and Disease Laboratory.
    Deficiency in Krüppel-like zinc finger transcription factor GLI-similar 3 (GLIS3) in humans is associated with the development of congenital hypothyroidism. However, the functions of GLIS3 in the thyroid gland and the mechanism by which GLIS3 dysfunction causes hypothyroidism are unknown. In the current study, we demonstrate that GLIS3 acts downstream of thyroid-stimulating hormone (TSH) and TSH receptor (TSHR) and is indispensable for TSH/TSHR-mediated proliferation of thyroid follicular cells and biosynthesis of thyroid hormone. Read More

    In silico and in vitro analysis of cross-reactivity between Yersinia pseudotuberculosis OmpF porin and thyroid-stimulating hormone receptor.
    Int J Biol Macromol 2017 Oct 25. Epub 2017 Oct 25.
    G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch, Russian Academy of Sciences, Prospect 100 let Vladivostoku, 159, Vladivostok, 690022, Russia.
    This work is devoted to the ascertainment of serological cross-reactivity between OmpF porin from Yersinia pseudotuberculosis (YpOmpF) and human thyroid-stimulating hormone receptor (hTSHR). Extracts containing hTSHR were isolated from surgical thyroid tissue of patients with clinical and diagnostic signs of diffuse toxic goiter. Monoclonal antibodies to hTSHR (mAbs) were shown to interact both with antigens in thyroid tissue extracts and with YpOmpF. Read More

    Risk factors of central lymph node metastasis of papillary thyroid carcinoma: A single-center retrospective analysis of 3273 cases.
    Medicine (Baltimore) 2017 Oct;96(43):e8365
    Department of Thyroid Surgery, the First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China.
    Due to the lack of an accurate preoperative diagnostic method of central lymph node metastasis (CLNM) of papillary thyroid cancer (PTC), the prophylaxis of central lymph node dissection remains controversial. The present study investigated the clinicopathological features of PTC patients and the risk factors of CLNM. The clinicopathological features of PTC patients with respect to sex, age, initial symptoms, observation, tumor diameter, multifocality, extrathyroidal invasion, and pathological data combined with other thyroid diseases, were analyzed retrospectively. Read More

    Transoral endoscopic total thyroidectomy vestibular approach: A case series and literature review.
    J Minim Access Surg 2017 Oct 23. Epub 2017 Oct 23.
    Associate Professor in Fellowship of Minimal Access Surgey, Siva Hospital, Institute of Minimal Access Surgery, Kanyakumari, Tamil Nadu, India.
    Conventional open thyroidectomy is often associated with post-operative complications including nerve damage, voice disturbances, paraesthesias, adhesions and prominent scarring. Several endoscopic surgical techniques have been reported as alternatives to conventional thyroidectomy. Natural orifice transluminal endoscopic surgery is a promising approach which leaves no scar, produces few complications and affords faster discharge from care. Read More

    Time to parathyroid function recovery in patients with protracted hypoparathyroidism after total thyroidectomy.
    Eur J Endocrinol 2018 Jan 24;178(1):105-113. Epub 2017 Oct 24.
    Endocrine Surgery UnitHospital del Mar, Departament de Cirurgia, Universitat Autònoma de Barcelona, Barcelona, Spain
    Objective: Hypocalcaemia is the most common adverse effect after total thyroidectomy. It recovers in about two-thirds of the patients within the first postoperative month. Little is known, however, about recovery of the parathyroid function (RPF) after this time period. Read More

    Persistent hyperthyroidism and de novo Graves' ophthalmopathy after total thyroidectomy.
    Endocrinol Diabetes Metab Case Rep 2017 13;2017. Epub 2017 Oct 13.
    Department of Endocrinology, Singapore General Hospital, Singapore, Singapore.
    We report a patient with Graves' disease who remained persistently hyperthyroid after a total thyroidectomy and also developed de novo Graves' ophthalmopathy 5 months after surgery. She was subsequently found to have a mature cystic teratoma containing struma ovarii after undergoing a total hysterectomy and salpingo-oophorectomy for an incidental ovarian lesion.

    Learning Points: It is important to investigate for other causes of primary hyperthyroidism when thyrotoxicosis persists after total thyroidectomy. Read More

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