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    Non-traumatic rupture of the superior thyroid artery with concomitant parathyroid adenoma and multinodular goiter.
    Acta Radiol Open 2017 Jul 27;6(7):2058460117722813. Epub 2017 Jul 27.
    Department of Radiology, University of the Ryukyus, Okinawa, Japan.
    Cervical hemorrhage due to non-traumatic, spontaneous rupture of the thyroid artery is rare, which usually results from arterial abnormalities or parathyroid or thyroid disorders. This report describes a 72-year-old woman who presented with a sore throat and slight neck swelling. Computed tomography (CT) revealed a large hematoma in the neck and mediastinum, due to extravasation from the major branch of the left superior thyroid artery. Read More

    Up-regulation of NADPH oxidase-mediated redox signaling contributes to the loss of barrier function in KRIT1 deficient endothelium.
    Sci Rep 2017 Aug 15;7(1):8296. Epub 2017 Aug 15.
    Department of Pharmacology and Physiology, University of Rochester, New York, USA.
    The intracellular scaffold KRIT1/CCM1 is an established regulator of vascular barrier function. Loss of KRIT1 leads to decreased microvessel barrier function and to the development of the vascular disorder Cerebral Cavernous Malformation (CCM). However, how loss of KRIT1 causes the subsequent deficit in barrier function remains undefined. Read More

    Temporal changes in thyroid nodule volume: lack of effect on paranodular thyroid tissue volume.
    Thyroid 2017 Aug 15. Epub 2017 Aug 15.
    Università di Roma Sapienza, Dipartimento di Medicina Interna e Specialità Mediche, Rome, Italy ;
    Background: The term "nodular goiter" has long been used to refer to a nodular thyroid gland, based on the assumption that nodule growth may be associated with hyperplasia of the surrounding non-nodular tissue. The aim of this prospective, multicenter, observational study was to determine whether nodule growth is accompanied by growth in the non-nodular tissue.

    Methods: Eight Italian thyroid-disease referral centers enrolled 992 consecutive patients with 1-4 benign nodules. Read More

    [Comparative long-term results of surgical treatment of patients with diffuse toxic goiter].
    Khirurgiia (Mosk) 2017 (8):13-17
    Pavlov Ryazan State Medical University, Ryazan, Russia.
    Aim: To analyze long-term outcomes of Graves' disease management.

    Material And Methods: There were 428 patients for the periods 2000-2004 and 2005-2010. Patients were called for examination and thyroid status control. Read More

    Iodine-Rich Herbs and Potassium Iodate Have Different Effects on the Oxidative Stress and Differentiation of TH17 Cells in Iodine-Deficient NOD.H-2(h4) Mice.
    Biol Trace Elem Res 2017 Aug 12. Epub 2017 Aug 12.
    The First Clinical College, Liaoning University of Traditional Chinese Medicine (TCM), Chongshan East Road No.72, Shenyang, Liaoning, 110032, China.
    Iodine-rich herbs such as seaweed, kelp, and sea tangle were widely used to treat various types of goiter with good effect and without any adverse side effects in China. When compared with potassium iodate (PI), iodine-rich herbs had a positive effect on the recovery of goiter resulting from iodine deficiency without any obvious harmful effects. In NOD. Read More

    Iodine status among pregnant women in rural Sabah, Malaysia.
    Asia Pac J Clin Nutr 2017 ;26(5):861-866
    School of Health Sciences, Universiti Sains Malaysia, Kelantan, Malaysia.
    Background And Objectives: In 2000, legislation on mandatory universal salt iodisation was enacted in Sabah, Malaysia, to reduce the incidence of iodine deficiency disorders among its population. To evaluate the iodine levels among pregnant women from selected rural divisions in Sabah 13 years after the enactment of the universal salt iodisation programme.

    Methods And Study Design: This cross-sectional study was conducted from 1 May to 30 June, 2013, in three rural divisions of Sabah (the Interior, the West Coast, and Kudat). Read More

    Factors Associated With Discordance Between Preoperative Parathyroid 4-Dimensional Computed Tomographic Scans and Intraoperative Findings During Parathyroidectomy.
    JAMA Surg 2017 Aug 9. Epub 2017 Aug 9.
    Department of Radiological Sciences, David Geffen School of Medicine, University of California, Los Angeles.
    Importance: Parathyroid 4-dimensional computed tomographic scans (4D-CTs) have emerged as an accurate and cost-effective initial localization study for patients with primary hyperparathyroidism. However, potential limitations and factors affecting the accuracy of preoperative 4D-CTs remain poorly defined.

    Objectives: To characterize factors associated with missed parathyroid lesions on preoperative 4D-CTs and to investigate patterns of commonly observed errors. Read More

    Binder syndrome: Clinical findings and surgical treatment of 18 patients at the Department of Plastic Surgery in Polanica Zdrój.
    Adv Clin Exp Med 2017 May-Jun;26(3):427-437
    Plastic Surgery Unit, Specialist Medical Centre, Polanica Zdrój, Poland.
    Background: Binder syndrome (BS) is an uncommon congenital underdevelopment of the maxilla and nasal skeleton. Other clinical features include a hypoplastic or absent anterior nasal spine; a short, flat nose with short columella; an acute nasolabial angle; a convex upper lip and class III malocclusion.

    Objectives: The aim of the study was to outline the major characteristics of BS and to present a variety of surgical treatment methods. Read More

    Etiologies and posttreatment conditions of thyrotoxic patients in Sylhet division, Bangladesh: A clinical series.
    Avicenna J Med 2017 Jul-Sep;7(3):125-129
    Institute of Nuclear Medicine and Allied Sciences, Sylhet, Bangladesh.
    Objective: The endeavor of the study was to analyze the posttreatment (postradioactive iodine therapy [RAI]) conditions of thyrotoxic patients in a tertiary level hospital.

    Materials And Methods: A retrospective study of 186 patients was conducted from 2012 to 2014 in Institute of Nuclear Medicine and Allied Sciences (INMAS), Sylhet MAG Osmani Medical College Campus. Patients' information regarding the etiologies and their disease status after getting RAI therapy was recorded. Read More

    Survey of Clinical Practice Patterns in the Management of 992 Hyperthyroid Patients in France.
    Eur Thyroid J 2017 Jul 5;6(3):152-159. Epub 2017 Jan 5.
    Department of Endocrinology, Metabolic Diseases and Nutrition, Pôle Cardio-Vasculaire et Métabolique, CHU Larrey, Université Paul Sabatier, Toulouse, France.
    Background: Considerable variations in diagnosis and therapeutic practices are reported for hyperthyroidism (HT) between countries.

    Methods: A clinical study was conducted among a representative sample of 263 endocrinologists in France. All consecutive patients seen for HT during the study period were included. Read More

    Plasma lncRNA GAS8-AS1 as a Potential Biomarker of Papillary Thyroid Carcinoma in Chinese Patients.
    Int J Endocrinol 2017 11;2017:2645904. Epub 2017 Jul 11.
    Department of Medical Genetics and Developmental Biology, Capital Medical University, Beijing 100069, China.
    Background: Long noncoding RNAs (lncRNAs) were recently shown to have potential in the diagnosis and prognosis for numerous cancers. lncRNA GAS8-AS1 is decreased in papillary thyroid cancer (PTC) tissue, but its plasma expression and clinical value in patients with PTC remain unknown.

    Materials And Methods: We investigated the expression profile of plasma GAS8-AS1 in 97 patients with PTC and 39 patients with nodular goiter by quantitative real-time polymerase chain reaction. Read More

    Pathological findings of Japanese Black Cattle living in the restricted area of the Fukushima Daiichi Nuclear Power Plant accident, 2013-2016.
    Anim Sci J 2017 Aug 4. Epub 2017 Aug 4.
    Laboratory of Veterinary Radiology and Radiation Biology, School of Veterinary Medicine, Kitasato University, Towada, Aomori, Japan.
    Fifty-one Japanese black cattle from four farms in the evacuation zone of the Fukushima nuclear accident were examined pathologically during the period, 2013-2016. We found no evidence of a radiation effect on pathological findings in any of these autopsy cases, although nine cases (3.7%) of enzootic bovine leukosis (EBL) and three cases (1. Read More

    Lymphocytic hidradenitis: A distinctive histopathological finding of annular erythema of Sjögren syndrome.
    Australas J Dermatol 2017 Aug 3. Epub 2017 Aug 3.
    College of Medicine, Chang Gung University, Taoyuan, Taiwan.
    Background/objectives: Lymphocytic hidradenitis is a non-specific histopathological feature observed in many dermatoses such as lupus erythematosus, morphea or scleroderma. When it occurs it is usually accompanied by the other distinctive histological features of those conditions. Isolated lymphocytic hidradenitis is uncommon and its clinical features and associated underlying medical conditions are still undetermined. Read More

    Fetal goitrous hypothyroidism treated by intra-amniotic levothyroxine administration: case report and review of the literature.
    J Pediatr Endocrinol Metab 2017 Aug 3. Epub 2017 Aug 3.
    .
    Background: Fetal goitrous hypothyroidism is mainly caused by maternal treatment of Graves' disease. Fetal goiter sometimes compresses the trachea and esophagus and may cause polyhydramnios, preterm labor, complications of labor and delivery, and neonatal respiratory disorder.

    Case Presentation: We report a case of fetal goitrous hypothyroidism in which the mother had Graves' disease, which was treated with propylthiouracil. Read More

    A case of neuroblastoma in DICER1 syndrome: Chance finding or noncanonical causation?
    Pediatr Blood Cancer 2017 Aug 2. Epub 2017 Aug 2.
    Department of Medical Genetics, Research Institute of the McGill University Health Centre, Montréal, Québec, Canada.
    DICER1 syndrome is an inherited disorder associated with at least a dozen rare, mainly pediatric-onset tumors. Its characterization remains incomplete. Some studies suggested that neuroblastoma (NB) may be involved in this syndrome. Read More

    An Indian Tertiary Care Hospital Scenario of Papillary Carcinoma of Thyroid.
    J Clin Diagn Res 2017 Jun 1;11(6):EC26-EC29. Epub 2017 Jun 1.
    Clinical Research Scholar, Department of Division of Pulmonary and Critical Care Medicine, Emory University, School of Medicine, Atlanta, GA, USA.
    Introduction: Thyroid carcinoma is the most common endocrine malignancy and its Papillary Histotype {Papillary Carcinoma of Thyroid (PTC)} is the most common type of Thyroid cancer. The clinicopathological features of PTC vary with geographical location.

    Aim: To describe the clinicopathological profile of PTC in a Tertiary Care Hospital located in Chennai, Tamil Nadu, India. Read More

    Pharyngolaryngeal symptoms associated with thyroid disease.
    Curr Opin Otolaryngol Head Neck Surg 2017 Jul 28. Epub 2017 Jul 28.
    Department of Otolaryngology-Head and Neck Surgery, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
    Purpose Of Review: The current review summarizes previous reports on laryngopharyngeal symptoms associated with thyroid disease. This review also includes pharyngolaryngeal symptoms caused by thyroidectomy. However, we focus on pharyngolaryngeal symptoms following uncomplicated thyroidectomy, as this is an important issue in the fields of otolaryngology. Read More

    Serum Thyroglobulin-A Sensitive Biomarker of Iodine Nutrition Status and Affected by Thyroid Abnormalities and Disease in Adult Populations.
    Biomed Environ Sci 2017 Jul;30(7):508-516
    Center for Endemic Disease Control, Chinese Center for Disease Control and Prevention, Harbin Medical University; Key Lab of Etiology and Epidemiology, National Health and Family Planning Commission (23618504), Harbin 150086, Heilongjiang, China.
    Objective: To evaluate the usefulness of the thyroglobulin (Tg) level in adults as a nutritional biomarker of iodine status and to identify the factors related to the serum Tg level.

    Methods: A cross-sectional study was conducted in adult populations of areas differing in iodine nutrition from three provinces (Autonomous Region) in China. Serum levels of thyroid hormones and Tg as well as thyroid autoantibodies were measured. Read More

    Increased risk for hypothyroidism after anticholinesterase pesticide poisoning: a nationwide population-based study.
    Endocrine 2017 Jul 29. Epub 2017 Jul 29.
    Department of Emergency Medicine, Chi-Mei Medical Center, Tainan, Taiwan.
    Purpose: Previous animal studies have reported that acute anticholinesterase pesticide (organophosphate and carbamate) poisoning may affect thyroid hormones. However, there is no human study investigating the association between hypothyroidism and anticholinesterase pesticide poisoning, and therefore, we conducted a retrospective nationwide population-based cohort study to delineate this issue.

    Methods: We identified 10,372 anticholinesterase pesticide poisoning subjects and matched 31,116 non-anticholinesterase pesticide poisoning subjects between 2003 and 2012 from the Nationwide Poisoning Database and the Longitudinal Health Insurance Database 2000, respectively, in a 1:3 ratio by index date, age, and sex for this study. Read More

    Circulating levels of PTEN and KLLN in papillary thyroid carcinoma: can they be considered as novel diagnostic biomarkers?
    Endocrine 2017 Jul 28. Epub 2017 Jul 28.
    Cellular and Molecular Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
    Purpose: PTEN and KLLN are two tumor suppressor genes located in 10q23, share a bidirectional promoter and have roles in carcinogenesis. Formerly, the role of PTEN mutations and KLLN epimutations were identified in incidence of thyroid lesions in individuals with Cowden syndrome, a rare autosomal dominant inherited disorder. This study is the first of its type to assess PTEN and KLLN circulating levels in patients with sporadic papillary thyroid carcinoma (PTC) and compare to patients with multinodular goiter (MNG) and healthy individuals. Read More

    Multinodular goiter in children: treatment controversies.
    J Pediatr Endocrinol Metab 2017 Aug;30(8):847-850
    .
    Background: Multinodular goiter (MG) is very common in adults. MG may occur in children in some exceptional circumstances. The objective of this study was to examine two cases of MG in children who relapsed soon after surgery and to discuss the treatment options in pediatric ages. Read More

    Myopathy in hyperthyroidism as a consequence of rapid reduction of thyroid hormone: A case report.
    Medicine (Baltimore) 2017 Jul;96(30):e7591
    Department of Endocrinology and Metabolism, West China Hospital, Sichuan University, Chengdu, China.
    Rationale: Myalgia and elevated creatine kinase (CK) are occasionally observed during the treatment of hyperthyroid patients. Relative hypothyroidism resulted from rapid thyroid hormone reduction had been promoted as a plausible cause of these myopathic changes, however rarely reported.

    Patient Concerns: We hereby presented a 20-year-old female with Grave's disease, who developed myopathy and elevated CK during rapid correction of thyroid hormone. Read More

    Comparison of three competitive immunoassays for measurement of TSH receptor antibodies in patients with Graves' disease.
    Scand J Clin Lab Invest 2017 Jul 24:1-6. Epub 2017 Jul 24.
    a Department of Clinical Biochemistry , Aalborg University Hospital , Aalborg , Denmark.
    Thyrotropin (TSH) receptor antibodies (TRAb) mediate the hyperthyroidism of Graves' disease (GD). The aim of the study was to compare the diagnostic performance and assay agreement between three immunoassays for the measurement of TRAb in patients with newly diagnosed GD. TRAb was measured with three different assays [H-TRAb (BRAHMS Diagnostica), M22-Man (RSR Limited) and M22-Aut (Roche Diagnostics)] in 387 participants who were recruited from two Danish population-based studies and diagnosed with GD (n = 101), multinodular toxic goitre (n = 88), primary autoimmune hypothyroidism (n = 100) or included as controls (n = 98). Read More

    The Concomitant Association of Thyroid Disorders and Myasthenia Gravis.
    Transl Neurosci 2017 30;8:27-30. Epub 2017 Apr 30.
    Division of Endocrinology and Metabolism, Department of Internal Medicine, Taipei Medical University Hospital, Taipei, Taiwan.
    Background: Some of the thyroid disorders (TD) and Myasthenia gravis (MG) are autoimmune related disease. The purpose of the study to evaluate the relationship of MG with all morphological and functional thyroid disorders.

    Methods: We constructed a population-based cohort study during the period from January 2000-December 2002 by using reimbursement data from the Bureau National Health Insurance (NHI) system in Taiwan. Read More

    Intra-capsular total thyroid enucleation versus total thyroidectomy in treatment of benign multinodular goiter. A prospective randomized controlled clinical trial.
    Int J Surg 2017 Jul 18;45:29-34. Epub 2017 Jul 18.
    Department of Surgery, Minia University Hospital, Egypt.
    Background: Due to high recurrence rate after subtotal thyroidectomy, most of centers have shifted to total thyroidectomy as a surgical treatment for benign multinodular goiter (BMNG), but serious complications, as laryngeal nerve affection & hypocalcaemia, are still present. This study aimed to evaluate treatment of BMNG using intra-capsular total thyroid enucleation in comparison to standard total thyroidectomy.

    Patients &methods: This is a prospective randomized controlled clinical trial conducted in a hospital in the period from December 2009 to December 2015. Read More

    The thyroid gland in postmenopausal women: physiology and diseases.
    Prz Menopauzalny 2017 Jun 30;16(2):33-37. Epub 2017 Jun 30.
    Department of Endocrinology, Centre of Postgraduate Medical Education, Bielański Hospital, Warsaw, Poland.
    The incidence of most thyroid diseases: hypothyroidism, nodular goitre, and cancer is highest among postmenopausal and elderly women. The diagnosis of thyroid dysfunction in this group of patients is difficult because the symptoms can be nonspecific or common with menopausal and ageing complaints. In the interpretation of thyroid function tests the physiological changes in secretion and metabolism of thyrotropin (TSH) and thyroid hormones must be considered, as well as the influence of comorbidities. Read More

    Clinical outcomes 1 year after empiric 131I therapy for hyperthyroid disorders: real life experience and predictive factors of functional response.
    Nucl Med Commun 2017 Sep;38(9):756-763
    aNuclear Medicine Department, Institut Universitaire de Cancérologie Oncopole, Institut Claudius Regaud bFaculty of Medicine, Paul Sabatier University cNuclear Medicine Department dEndocrinology Department, Larrey Hospital, University Hospitals of Toulouse eCancer Research Center of Toulouse, Paul Sabatier University, Toulouse, France.
    Radioiodine is a therapeutic option in Europe for Graves' disease (GD) and toxic multinodular goiter (MNG).

    Purpose: To compare empiric and calculated I activities using 2013 EANM recommendations. To look for predictive factors of therapeutic response to an empiric activity of I. Read More

    Transoral thyroidectomy: why is it needed?
    Gland Surg 2017 Jun;6(3):272-276
    Department of Surgery, Police General Hospital, Faculty of Medicine, Siam University, Bangkok, Thailand.
    Transoral thyroidectomy (TOT) represents reasonably the desirable minimally invasive approach to the gland due to the scarless non-visible incisions, the limited distance between the gland and the access that minimize tissue dissection and respect of the surgical anatomical planes. Patients are routinely selected according to an extensive inclusion criteria: (I) ultrasonographically (US) estimated thyroid diameter not larger than 10 cm; (II) US gland volume ≤45 mL; (III) nodule size ≤50 mm; (IV) a benign tumor, such as a thyroid cyst, single-nodular goiter, or multinodular goiter; (V) follicular neoplasm; (VI) papillary microcarcinoma without lymph node metastasis. The operation is realized through median, central approach which allows bilateral exploration of the thyroid gland and central compartment. Read More

    Comparative Efficacy and Toxicity of Different Species of Sargassum in Haizao Yuhu Decoction in PTU-Induced Goiter Rats.
    Evid Based Complement Alternat Med 2017 21;2017:3526186. Epub 2017 Jun 21.
    Beijing University of Chinese Medicine, Beijing, China.
    Background: Haizao Yuhu Decoction has been widely used to treat thyroid-related diseases especially goiter with few side effects in traditional Chinese medicine (TCM), including herb pair Sargassum (HZ) and Glycyrrhizae Radix et Rhizoma (GC), as one of "eighteen antagonistic medicaments." The two different species of Sargassum, Sargassum fusiforme (Sf) and Sargassum pallidum (Sp), are not clearly differentiated in clinical use, so that herb pair Sf-GC and Sp-GC could show different effect and toxicity.

    Methods: We investigated the antigoitrous effect and toxicity and clarified the potential underlying mechanism of the two different species of Sargassum in HYD (HYDf and HYDp) in PTU-reduced goiter rats. Read More

    Thyroid-Stimulating Hormone Receptor Antibodies in Pregnancy: Clinical Relevance.
    Front Endocrinol (Lausanne) 2017 30;8:137. Epub 2017 Jun 30.
    Unit of Endocrinology, Department of Medicine and Sciences of Aging, Ce.S.I.-Me.T., University of Chieti-Pescara, Chieti, Italy.
    Graves' disease is the most common cause of thyrotoxicosis in women of childbearing age. Approximately 1% of pregnant women been treated before, or are being treated during pregnancy for Graves' hyperthyroidism. In pregnancy, as in not pregnant state, thyroid-stimulating hormone (TSH) receptor (TSHR) antibodies (TRAbs) are the pathogenetic hallmark of Graves' disease. Read More

    Recurrent Laryngeal Nerve Injury In Total Versus Subtotal Thyroidectomy.
    J Ayub Med Coll Abbottabad 2016 Jul-Sep;28(3):559-561
    Department of ENT, Ayub Teaching Hospital, Abbottabad, Pakistan.
    Background: Both Total and Subtotal Thyroidectomy are correct treatment options for symptomatic Euthyroid Multinodular Goitre. The choice depends upon surgeon's preference due to consideration of disadvantages like permanent hypothyroidism in Total Thyroidectomy and high chances of recurrence in Subtotal Thyroidectomy. Many surgeons believe that there is a higher incidence of Recurrent Laryngeal nerve injury in Total Thyroidectomy which affects their choice of surgery. Read More

    Incidental diagnosis of the tall-cell variant of the papillary microcarcinoma of the thyroid gland requires completion lymphadenectomy: case report.
    Pol Przegl Chir 2017 Jun;89(3):40-43
    Department of General, Abdominal and Vascular Surgery, Department of Radiology and Nuclear Medicine, University Hospital Magdeburg A.ö.R., Magdeburg, Germany.
    Papillary thyroid carcinoma is the most common neoplasm of the thyroid gland which is usually associated with a very good prognosis. The aim of this case report is to present the disease course of a rare tumor of the thyroid gland, which is worthwhile due to its extraordinary appearance and specific management. A 46-year-old patient presented with a pronounced right-sided, but bilateral, multinodular goiter, with a volume of approximately 80 mL, as assessed on ultrasonography. Read More

    Role of intraoperative neuromonitoring of the recurrent laryngeal nerves during thyroid reoperations of recurrent goiter.
    Pol Przegl Chir 2017 Jun;89(3):11-15
    Department of Endocrine, General and Vascular Surgery, Medical University of Lodz; Head: Prof. Krzysztof Kuzdak, MD PhD.
    Reoperations of the thyroid gland are challenging to any surgeon. Such procedures are technically difficult and involve higher risk of complications than primary procedures. Recurrent laryngeal nerve (RLN) palsy is one of such complications The aim of the study was to evaluate the effectiveness of intraoperative neuromonitoring (IONM) in preventing RLN palsy during recurrent goiter operations. Read More

    Survival times for cats with hyperthyroidism treated with a 3.35 mCi iodine-131 dose: a retrospective study of 96 cases.
    J Feline Med Surg 2017 Jul 1:1098612X17718416. Epub 2017 Jul 1.
    1 Micen Vet Referral Centre, Créteil, France.
    Objectives Radioiodine ((131)I) dose determination using radiotracer kinetic studies or scoring systems, and fixed relatively high (131)I dose (ie, 4 or 5 mCi) administration, are effective and associated with prolonged survival times for hyperthyroid cats. The latter method is less complicated but could expose patients and veterinary personnel to unnecessary levels of radiation. The aim of this study was to retrospectively evaluate the efficacy of a fixed 3. Read More

    Referral Trends for Surgical Management of Graves' Disease.
    Thyroid 2017 Jul 12. Epub 2017 Jul 12.
    Henry Ford Hospital, Otolaryngology , 6777 West Maple Road , West Bloomfield, Michigan, United States , 48322 ;
    Background: Treatment algorithms for Graves' disease (GD) differ internationally and frequency of referral for surgical intervention varies markedly between areas. Given the potential benefits of thyroidectomy over radioactive iodine (RAI) and medical therapy, surgery may be underutilized. To better understand the approach of endocrinologists to GD, we assessed the rationale for consultation among patients referred for thyroidectomy to an endocrine surgery practice in the United States. Read More

    Thyroid testing in acutely ill patients may be an expensive distraction.
    Biochem Med (Zagreb) 2017 Jun;27(2):300-307
    Section of Endocrinology, YYF Hospital, Caerphilly, UK.
    In health, an efficient negative feedback mechanism maintains serum thyroid hormone concentrations within an exquisitely controlled narrow range. Therefore any change that occurs to thyroid hormones in intrinsic thyroid disease is concordant and easy to interpret. Optimal functioning of the many tissues they influence is thereby facilitated. Read More

    A pair of DICER1-positive monozygotic twins: One with pleuropulmonary blastoma, another with acute transient hepatitis.
    Pediatr Blood Cancer 2017 Jul 8. Epub 2017 Jul 8.
    Hematology Oncology Center, Beijing Children's Hospital, Capital Medical University, Beijing Key Laboratory of Pediatric Hematology Oncology, National Key Discipline of Pediatrics, Ministry of Education, MOE Key Laboratory of Major Diseases in Children, Beijing, China.
    Pleuropulmonary blastoma (PPB) is the most common primary malignant neoplasm of the lung in children that is associated with a germline mutation in DICER1. In this report, we share an interesting case of a pair of monozygotic twins: one of them developed PPB when she was 4-year old, while the other developed acute transient hepatitis when she was 5-year old. Next-Gen sequencing for DICER1 mutations of their family revealed that both twins and their mother had c. Read More

    Poorly Differentiated Thyroid Carcinoma: 10-Year Experience in a Southeast Asian Population.
    Endocrinol Metab (Seoul) 2017 Jun;32(2):288-295
    Section of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Philippine General Hospital, Manila, Philippines.
    Background: No previous studies have been published on poorly differentiated thyroid carcinoma (PDTC) in Southeast Asia.

    Methods: We included all adult PDTC patients diagnosed using the Turin criteria at the Philippine General Hospital from 2006 to 2015. The data collected included demographics, clinical presentation, histopathology, treatment, and outcomes. Read More

    Free Thyroxine, Anti-Thyroid Stimulating Hormone Receptor Antibody Titers, and Absence of Goiter Were Associated with Responsiveness to Methimazole in Patients with New Onset Graves' Disease.
    Endocrinol Metab (Seoul) 2017 Jun;32(2):281-287
    Department of Internal Medicine, Dankook University Hospital, Dankook University College of Medicine, Cheonan, Korea.
    Background: Anti-thyroid drug therapy is considered a treatment of choice for Graves' disease; however, treatment response varies among individuals. Although several studies have reported risk factors for relapse after initial treatment, few have assessed responsiveness during the early treatment period. Our study aimed to identify the clinical characteristics for responsiveness to methimazole. Read More

    Higher urinary bisphenol A concentration and excessive iodine intake are associated with nodular goiter and papillary thyroid carcinoma.
    Biosci Rep 2017 Aug 27;37(4). Epub 2017 Jul 27.
    Department of Endocrinology, Qilu Hospital of Shandong University, Jinan 250012, China
    In the present study, we investigated whether bisphenol A (BPA) levels and excessive iodine intake were associated with papillary thyroid carcinoma (PTC) and nodular goiter (NG). We determined total BPA concentrations (TBC) in paired serum and urine samples, and urinary iodine concentrations (UIC) in urine samples collected from PTC patients, NG patients, and healthy individuals, then compared BPA concentrations and UIC within and between each patient group. The results showed that there were no gender-specific differences in serum TBC and UIC in each group, and no differences across all patient groups. Read More

    Self-reported adherence to diet and preferences towards type of meal plan in patient with type 2 diabetes mellitus. A cross-sectional study.
    Nutr Metab Cardiovasc Dis 2017 Jul 1;27(7):642-650. Epub 2017 Jun 1.
    Department of Medical Sciences, University of Turin, Turin, Italy. Electronic address:
    Background And Aims: Few studies have evaluated the attitudes of patients with type 2 diabetes mellitus (T2DM) towards the given dietary plans. In this study, we aimed to evaluate: i) the self-reported adherence of T2DM patients to the prescribed diets; ii) the use of other types of diet schemes; iii) the patients' preferences towards the type of meal plans.

    Methods And Results: A 16 multiple-choice items questionnaire was administered to 500 T2DM patients; 71. Read More

    Thyroid Function and Ultrasonography Abnormalities in Lithium-Treated Bipolar Patients: A Cross-sectional Study with Healthy Controls.
    Noro Psikiyatr Ars 2017 Jun 1;54(2):108-115. Epub 2017 Jun 1.
    Department of Endocrinology, İzmir Bozyaka Training and Research Hospital, İzmir, Turkey.
    Introduction: Lithium has many effects on thyroid physiology. Although these side effects have been known for a long time, large sample studies of lithium-treated patients using ultrasonography are lacking. The aim of this study is to investigate the detailed thyroid morphologies, hormone levels, and antibodies of lithium-treated patients compared with healthy controls. Read More

    Boron - A potential goiterogen?
    Med Hypotheses 2017 Jul 26;104:63-67. Epub 2017 May 26.
    Yaroslavl State University, Yaroslavl, Russia; RUDN University, Moscow, Russia; Orenburg State University, Orenburg, Russia.
    The iodine deficiency disorders (IDD) include a variety of disturbances such as decreased fertility, increased perinatal and infant mortality, impaired physical and intellectual development, mental retardation, cretinism, hypothyroidism, and endemic goiter (EG). The occurrence of the latter is determined by interplay between genetic and environmental factors. The major environmental factor is iodine status that is required for normal thyroid hormone synthesis. Read More

    Subclinical Hyperthyroidism: When to Consider Treatment.
    Am Fam Physician 2017 Jun;95(11):710-716
    Allegheny Health Network, Pittsburgh, PA, USA.
    Subclinical hyperthyroidism is defined by a low or undetectable serum thyroid-stimulating hormone level, with normal free thyroxine and total or free triiodothyronine levels. It can be caused by increased endogenous production of thyroid hormone (e.g. Read More

    Effect of Antithyroid Therapies on Bone and Body Composition: A Prospective, Randomized, Clinical Study Comparing Antithyroid Drugs with Radioiodine Therapy.
    Indian J Endocrinol Metab 2017 Jul-Aug;21(4):531-534
    Department of Endocrinology, Army Hospital (R & R), New Delhi, India.
    Background: Thyrotoxicosis is associated with loss of body weight and bone mineral content (BMC). Antithyroid drugs (ATD) and radioiodine therapy (RIT) are the common options for the management of thyrotoxicosis. We evaluated the effect of ATD and RIT on BMC and body composition. Read More

    Newborn Screening for Thyroid-stimulating Hormone as an Indicator for Assessment of Iodine Status in the Republic of Macedonia.
    J Med Biochem 2016 Oct 2;35(4):385-389. Epub 2016 Nov 2.
    Laboratory for Neonatal Thyroid Screening, Department of Endocrinology and Genetics, University Children's Hospital, Skopje, Republic of Macedonia.
    Background: Iodine deficiency is associated with goiter and impaired brain function leading to cretinism. An increased frequency of thyroid-stimulating hormone (TSH) measurements above 5 mlU/L on newborn screening points toward an impaired iodine status of the population.

    Methods: A 13-year retrospective analysis was performed in 228,266 newborns participating in the national thyroid newborn screening program. Read More

    Association of Preoperative Serum Thyroid-stimulating Hormone Levels with Thyroid Cancer in Patients with Nodular Thyroid Disease.
    World J Nucl Med 2017 Jul-Sep;16(3):202-205
    Department of Nuclear Medicine, Nuclear Medicine, Oncology and Radiotherapy Institute, Islamabad, Pakistan.
    The aim of the current study was to determine the frequency of carcinoma thyroid among patients presenting with goiter and its association with preoperative serum thyroid-stimulating hormone (TSH) levels. A total of 73 (n = 73) adult patients of either gender with solitary solid cold nodule and multinodular goiter with predominant solid cold nodule were analyzed. All surgically resected samples were sent for histopathology. Read More

    Resveratrol has anti-thyroid effects both in vitro and in vivo.
    Food Chem Toxicol 2017 Sep 28;107(Pt A):237-247. Epub 2017 Jun 28.
    Department of Medicine and Sciences of Aging, 'G. D'Annunzio' University of Chieti-Pescara, via dei Vestini, 66100 Chieti, Italy; Centre on Aging Science and Translational Medicine (CeSI-MeT), 'G. D'Annunzio' University of Chieti-Pescara, via dei Vestini, 66100 Chieti, Italy. Electronic address:
    Resveratrol is a natural polyphenol with antioxidant, anti-inflammatory, and antiproliferative properties. We have shown previously that resveratrol decreases sodium/iodide symporter expression and iodide uptake in thyrocytes, both in vitro and in vivo. In the present study, we further investigated the effects of resveratrol, with evaluation of the expression of additional thyroid-specific genes in the FRTL-5 rat thyroid cell line: thyroglobulin, thyroid peroxidase, TSH receptor, Nkx2-1, Foxe1 and Pax8. Read More

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