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    Urinary iodine concentration (UIC) could be a promising biomarker for predicting goiter among school-age children: A systematic review and meta-analysis.
    PLoS One 2017 22;12(3):e0174095. Epub 2017 Mar 22.
    School of Basic Medical Science, Beijing University of Chinese Medicine, Beijing, China.
    Objectives: To evaluate whether urinary iodine concentration (UIC) can predict goiter among school-age children, and to assess the association between UIC and goiter prevalence.

    Methods: We searched the MEDLINE, EMBASE, Cochrane Library (Cochrane Database of Systematic Reviews), Web of Science, CNKI, VIP, and Wan Fang databases for relevant reports in both English and Chinese up to August 25, 2016. The mean differences (MD) and 95% confidence intervals (CI) were calculated for the UIC and goiter prevalence assessments. Read More

    Quantification of thyroid cancer and multinodular goiter risk in the DICER1 syndrome: a family-based cohort study.
    J Clin Endocrinol Metab 2017 Feb 2. Epub 2017 Feb 2.
    Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD.
    Context: The risk of thyroid cancer and multinodular goiter (MNG) in the DICER1 syndrome, a rare tumor-predisposition disorder, is unknown.

    Objective: To quantify the risk of thyroid cancer and MNG in individuals with the DICER1 syndrome.

    Design: Family-based cohort study. Read More

    Iodine deficiency: Clinical implications.
    Cleve Clin J Med 2017 Mar;84(3):236-244
    Department of Endocrinology, Diabetes and Metabolism, Cleveland Clinic, Cleveland, OH, USA.
    Iodine is crucial for thyroid hormone synthesis and fetal neurodevelopment. Major dietary sources of iodine in the United States are dairy products and iodized salt. Potential consequences of iodine deficiency are goiter, hypothyroidism, cretinism, and impaired cognitive development. Read More

    Evaluation of platelet indices as a useful marker in papillary thyroid carcinoma.
    Bratisl Lek Listy 2017 ;118(3):153-155
    Objectives: Our aim was to investigate platelets (PLT) and their indices - mean platelet volume (MPV), platelet distribution width (PDW) and plateletcrit (PCT) - in the differential diagnosis of benign and malignant thyroid disorders.

    Background: Platelet and platelet indices recently started to be defined as an useful clinical marker in cancer patients. Their higher reproducibility rates and low cost provide them a wide range of usage. Read More

    Simultaneous induction of Graves' hyperthyroidism and Graves' ophthalmopathy by TSHR genetic immunization in BALB/c mice.
    PLoS One 2017 20;12(3):e0174260. Epub 2017 Mar 20.
    Department of Endocrinology, Jingling Hospital, Medical School of Nanjing University, Nanjing, P.R. China.
    Background: Graves' disease is the most common form of autoimmune thyroid disorder, characterized by hyperthyroidism due to circulating autoantibodies. To address the pathological features and establish a therapeutic approach of this disease, an animal model carrying the phenotype of Graves' disease (GD) in concert with Graves' Ophthalmopathy (GO) will be very important. However, there are no ideal animal models that are currently available. Read More

    Relationship Among Pulmonary Hypertension, Autoimmunity, Thyroid Hormones and Dyspnea in Patients With Hyperthyroidism.
    Am J Med Sci 2017 Apr 1;353(4):374-380. Epub 2017 Feb 1.
    Department of Endocrinology and Metabolism, Faculty of Medicine, Namik Kemal University, Tekirdag, Turkey.
    Objective: Previous studies have reported conflicting results regarding the mechanisms underlying the pathophysiology of pulmonary hypertension (PHT) in patients with hyperthyroidism. Therefore, in this study, we investigated the association between PHT and thyroid-stimulating hormone (TSH) receptor antibody, thyroid peroxidase antibody, thyroglobulin antibody, TSH, fT3, fT4 and dyspnea during daily activities in a large population of patients with hyperthyroidism.

    Methods: A total of 129 consecutive patients with hyperthyroidism, 37 with hypothyroidism and 38 euthyroid controls were enrolled in this study. Read More

    A concise review of Hashimoto thyroiditis (HT) and the importance of iodine, selenium, vitamin D and gluten on the autoimmunity and dietary management of HT patients.Points that need more investigation.
    Hell J Nucl Med 2017 Mar 20. Epub 2017 Mar 20.
    Department of Internal Medicine, Naval Hospital of Crete, Chania, Greece.
    Hashimoto's thyroiditis (HT) is a chronic autoimmune thyroid disease caused by an interaction between genetic factors and environmental conditions, both of which are yet to be fully understood. The management of HT depends on its clinical manifestations, commonly including diffuse or nodular goiter with euthyroidism, subclinical hypothyroidism and permanent hypothyroidism. However, in most cases of patients with HT, lifelong levothyroxine substitution is required. Read More

    Tuberculous Dactylitis with Concomitant Thyroid Involvement: A Rare Presentation of Childhood Tuberculosis.
    J Coll Physicians Surg Pak 2017 Mar;27(3):S21-S22
    Department of Paediatric Medicine, The Children's Hospital and The Institute of Child Health, Lahore.
    Extrapulmonary tuberculosis rarely presents as thyroid involvement along with other manifestations, and poses a diagnostic challenge on account of paucibacillary nature of disease. In general, the diagnosis of tuberculosis is based on epidemiological risk factors, clinical features, imaging studies, in addition to a positive skin testing or Interferon Gamma Release Assay (IGRA). A 14-year boy presented with history of fever and weight loss for one year. Read More

    Airway Management in Patients with Tracheal Compression Undergoing Thyroidectomy: A Retrospective Analysis.
    Anesth Essays Res 2017 Jan-Mar;11(1):110-116
    Department of Anesthesiology, Government Medical College, Kozhikode, Kerala, India.
    Background: Airway management in large and retrosternal goiters with tracheal compression is often fraught with challenges and is a source of apprehension among anesthesiologists globally.

    Aims: In this study we attempt to delineate the preferred techniques of airway management of such cases in our institution and also to assess whether airway management was unnecessarily complicated.

    Setting And Design: Retrospective analysis. Read More

    [Expression of microRNA-221 and IL-17 in papillary thyroid carcinoma and correlation with clinicopathologic features].
    Zhonghua Bing Li Xue Za Zhi 2017 Mar;46(3):160-165
    Department of Pathology, School of Basic Medical Science, Chongqing Medical University, Chongqing 400016, China.
    Objective: To study the expression of microRNA-221(miR-221) and IL-17 in papillary thyroid carcinoma (PTC) and their roles in the carcinogenesis of PTC. Methods: Real-time RT-PCR, Western blot and immunohistochemistry (IHC) were used to detect the expression of miR-221 and IL-17 in 40 cases of PTC, 20 adjacent normal thyroid tissues and 20 cases of nodular goiter, and the correlation with clinicopathologic features was analyzed. Results: (1)The expression level of miR-221 was significantly higher in PTC compared with nodular goiter and adjacent normal thyroid tissue (P<0. Read More

    Iodine Deficiency and Iodine Prophylaxis in Pregnancy.
    Recent Pat Endocr Metab Immune Drug Discov 2017 Mar 9. Epub 2017 Mar 9.
    Department of Endocrinology, Jagiellonian University Medical College ul. Kopernika 17, 31-501 Krakow. Poland.
    Background: Physiological changes in pregnancy result in increased iodine demand, which may not be met in areas of mild-to-moderate iodine deficiency or borderline sufficiency. As a pregnant woman is the only source of thyroid hormones for her child during early gestation, iodine deficiency-induced hypothyroxinemia may have deleterious effects on fetal development.

    Objective: To present the current approach to iodine deficiency and its prophylaxis during pregnancy. Read More

    Surveys in Areas of High Risk of Iodine Deficiency and Iodine Excess in China, 2012-2014: Current Status and Examination of the Relationship between Urinary Iodine Concentration and Goiter Prevalence in Children Aged 8-10 Years.
    Biomed Environ Sci 2017 Feb;30(2):88-96
    Institute for Iodine Deficiency Disorders Control, Center for Endemic Disease Control, Chinese Center for Disease Control and Prevention, Harbin Medical University, Harbin 150081, Heilongjiang, China.
    Objective: We aimed to evaluate goiter prevalence and iodine nutritional status in areas with high levels of water iodine; to monitor the prevalence of iodine deficiency disorders (IDD) in areas at high risk of IDD; and to compare the prevalence of goiter and urine iodine (UI) concentrations between children living in the two areas.

    Methods: Based on surveillance from 2012-2014, we analyzed the concentration of UI and prevalence of goiter in 8-10-year-old children from 12 high-risk IDD provinces, and from 8 provinces and municipalities with excessive water iodine. We calculated goiter prevalence for each UI level according to World Health Organization (WHO) standards and constructed predictive prevalence curves. Read More

    [Pyoderma gangrenosum associated with anti-proteinase 3 antineutrophil cytoplasmic antibodies (PR3-ANCA) induced by propylthiouracil].
    Ann Dermatol Venereol 2017 Mar 10. Epub 2017 Mar 10.
    Département de dermatologie, grand hôpital de Charleroi (GHDC), Grand'Rue 3, 6000 Charleroi, Belgique.
    Background: Synthetic antithyroid drugs are often used in the treatment of hyperthyroidism, regardless of aetiology. They may cause various side effects, including the development of anti-neutrophil cytoplasmic antibodies (ANCA), ANCA-associated vasculitis, and neutrophilic dermatoses. Propylthiouracil (PTU) is the antithyroid drug most frequently implicated in ANCA-associated diseases specifically involving anti-myeloperoxidase ANCA (MPO-ANCA). Read More

    [The iodine prophylaxis: the experience in the Autonomous Province of Bolzano (South Tyrol).]
    Recenti Prog Med 2017 Feb;108(2):90-97
    Servizio di Dietetica e Nutrizione Clinica, Comprensorio Sanitario di Bolzano.
    Since ancient times in South Tyrol there was evidence of endemic goitre caused by iodine deficiency. In the early 80's an epidemiological research on adults and primary and secondary school children reported in the least a prevalence of goitre from grade 1 B-3 (WHO) of 23,66% (limits WHO >5%) and an urinary iodine of 10,2 µgI/L. Therefore South Tyrol population presented heavy endemic goitre. Read More

    Effect of excess iodine intake on thyroid diseases in different populations: A systematic review and meta-analyses including observational studies.
    PLoS One 2017 10;12(3):e0173722. Epub 2017 Mar 10.
    Department of Social and Preventive Epidemiology, Graduate School of Medicine, the University of Tokyo, Bunkyo-ku, Tokyo, Japan.
    Background: Although several reports concerning the association of iodine excess and thyroid disease have appeared, no systematic review of the association between iodine excess intake and thyroid diseases, especially hyperthyroidism and hypothyroidism, has yet been reported.

    Method: We conducted a systematic search of Ovid MEDLINE, PubMed, Cochrane Central Register of Controlled Trials databases, Ichushi-Web and CiNii database for intervention trials and observational studies. Search terms were constructed from related words for excess AND iodine intake or excretion AND thyroid hormones or diseases AND study designs. Read More

    MANAGEMENT OF ENDOCRINE DISEASE: Subclinical Thyrotoxicosis: Prevalence, Causes and Choice of Therapy.
    Eur J Endocrinol 2017 Mar 8. Epub 2017 Mar 8.
    P Laurberg, Department of Endocrinology, Aalborg University Hospital, Aalborg, Denmark.
    Subclinical thyrotoxicosis is a condition affecting up to 10% of the population in some studies. We have reviewed literature and identified studies describing prevalences, causes and outcomes of this condition. Treatment should be considered in all subjects if this biochemical abnormality is persistent, especially in case of symptoms of thyrotoxicosis or in the presence of any complication. Read More

    [Genetic analysis of TPO, DUOX2 and DUOXA2 genes in children with permanent congenital hypothyroidism suspected dyshormonogenesis].
    Zhonghua Er Ke Za Zhi 2017 Mar;55(3):210-214
    Department of Guangzhou Newborn Screening Center, Guangzhou Women and Children's Medical Center, Guangzhou 510180, China.
    Objective: To explore the TPO, DUOX2 and DUOXA2 genotypes and phenotypes of children with permanent congenital hypothyroidism(PCH) suspected dyshormonogenesis in Guangzhou, identified and treated at Guangzhou Newborn Screening Center. Six of them were born between 2011 and 2012. Method: Retrospectively analyzed the clinical data of 9 children with PCH suspected dyshormonogenesis. Read More

    Hashimoto's thyroiditis: Relative recurrence risk ratio and implications for screening of first degree relatives.
    Clin Endocrinol (Oxf) 2017 Mar 8. Epub 2017 Mar 8.
    Department of Endocrinology, Seth GSMC and KEM Hospital, Parel, Mumbai, 400091.
    Context: The relative recurrence risk ratio (λR ) for Hashimoto's thyroiditis (HT) has not been widely studied. The age at which thyroid function evaluation should be initiated for relatives of HT patients remains unclear.

    Objective: To study λR and age-related prevalence of HT in first degree relatives of HT patients. Read More

    A Fifteen Year Experience of Total Thyroidectomy for the Management of Simple Multinodular Goitres in a Low Medium Income Country.
    S Afr J Surg 2016 Nov;54(4):40-45
    Department of Surgery, University College Hospital, Ibadan, Nigeria.
    Introduction: Total thyroidectomy as a treatment for simple multinodular goitre is not well recognised in most centres in low middle income countries.

    Method: This paper is a retrospective review of outcomes of total thyroidectomy for simple multinodular goitres in the last fifteen years in a tertiary hospital in Nigeria.

    Results: A total of 652 thyroidectomies were done from January 2001 to December 2015. Read More

    Neglected nontoxic multinodular goiter presented as a large neck mass.
    Clin Case Rep 2017 Mar 20;5(3):357-358. Epub 2016 Dec 20.
    Department of Anatomy-Histology-Embryology University of Ioannina School of Medicine Ioannina Greece.
    Large multinodular goiters, obvious to the naked eye, are rarely confronted by clinicians nowadays; yet they do have a place in the differential diagnosis of the neck masses. Due to the fact that 80% of the neck masses in adults are related to malignancy, the later should be ruled out. Read More

    Incidental 99m Tc-HDP Uptake in a Dominant Thyroid Nodule on Bone Scan.
    Clin Nucl Med 2017 Mar 3. Epub 2017 Mar 3.
    From the Department of Nuclear Medicine, Concord Repatriation General Hospital, Concord, New South Wales, Australia.
    A 67-year-old woman was referred for a bone scan for evaluation of increasing serum alkaline phosphatase levels. Bone scan revealed no abnormal uptake in the skeleton. However, intense hypervascularity and delayed tracer uptake were incidentally identified in an enlarged right thyroid gland. Read More

    Pituitary Adenoma Recurrence Suspected on Central Hyperthyroidism Despite Empty Sella and Confirmed by 68 Ga-DOTA-TOC PET/CT.
    Clin Nucl Med 2017 Mar 3. Epub 2017 Mar 3.
    From the *Hôpital Tenon, AP-HP, Médecine Nucléaire, Paris; †Université Pierre et Marie Curie, Paris; and ‡Hôpital Saint-Antoine, AP-HP, Endocrinologie, Paris, France.
    Thyrotropin-secreting pituitary adenomas are very rare tumors, known to present overexpression of somatostatin receptor subtype 2 and which may consequently demonstrate abnormal uptake on Ga-DOTA-TOC PET/CT. A 67-year-old woman with a history of operated pituitary macroadenoma presented with symptoms of hyperthyroidism including a large goiter. Her serum thyroid hormone levels were in favor of central hyperthyroidism. Read More

    Amyloid Goiter: A Diagnosis to Consider in Diffuse Fatty Infiltration of the Thyroid.
    J Ultrasound Med 2017 Mar 4. Epub 2017 Mar 4.
    Department of Radiology, Istanbul University, Istanbul, Turkey.
    An amyloid goiter is the presence of amyloid protein in the thyroid in sufficient amounts to produce enlargement of the gland, accompanied by fat deposition of varying extents. It can be seen in long-standing inflammatory disorders such as familial Mediterranean fever. Imaging findings depend on the amount of fat and amyloid deposition; however, the main imaging finding is diffuse fatty infiltration of the thyroid. Read More

    Thyroid lesions in patients with acromegaly - case-control study and update to the meta-analysis.
    Endokrynol Pol 2017 ;68(1):2-6
    Department of Endocrinology, Metabolism and Internal Medicine, Poznan University of Medical Sciences.
    Introduction: Acromegaly results from oversecretion of growth hormone and subsequently insulin growth factor-1. According to some authors, the disease can cause increased prevalence of nodular goitre and thyroid cancer (TC). However, the number of studies comparing acromegalic patients with control groups is low. Read More

    Elevated Concentrations of SERPINE2/Protease Nexin-1 and Secretory Leukocyte Protease Inhibitor in the Serum of Patients with Papillary Thyroid Cancer.
    Dis Markers 2017 31;2017:4962137. Epub 2017 Jan 31.
    Department of Immunoendocrinology, Chair of Endocrinology, Medical University of Lodz, Sterlinga 3, 91-425 Lodz, Poland.
    Introduction. SERPINE2 and secretory leukocyte protease inhibitor (SLPI) are proteins with anticoagulant properties which could promote solid tumor growth. However, their role in the pathogenesis of thyroid cancer has not been determined. Read More

    [Congenital hypothyroidism in Dakar: about 28 cases].
    Pan Afr Med J 2016 29;25:46. Epub 2016 Sep 29.
    Département de Pédiatrie, Université Cheikh Anta Diop de Dakar, Sénégal.
    Child hypothyroidism has been little studied in Senegal. The aim of this study was to evaluate the epidemiological, diagnostic and evolutionary aspects of congenital hypothyroidism. We conducted a descriptive-analytical retrospective study of all children treated for congenital hypothyroidism at the Albert-Royer National Children's Hospital Center over the period from 2001 to 2014 (14 years). Read More

    Effects of 6 months of resveratrol versus placebo on pentraxin 3 in patients with type 2 diabetes mellitus: a double-blind randomized controlled trial.
    Acta Diabetol 2017 Feb 25. Epub 2017 Feb 25.
    Department of Medical Sciences, University of Turin, Corso Dogliotti 14, 10126, Turin, Italy.
    Aims: The anti-inflammatory effects of the polyphenol resveratrol in patients with type 2 diabetes mellitus (T2DM) are controversial. Its role on pentraxin 3 (PTX3) concentrations, a human acute phase protein, has never been evaluated. Our aim was to determine whether a two-dosage resveratrol supplementation (500 and 40 mg/day) has an impact on PTX3 values in T2DM patients from a double-blind randomized placebo-controlled trial. Read More

    Thyroid volume and serum calcitonin changes during pregnancy.
    J Endocrinol Invest 2017 Feb 22. Epub 2017 Feb 22.
    Department of Endocrine and Metabolic Diseases, IRCCS Istituto Auxologico Italiano, Milan, Italy.
    Background: Pregnancy has a profound impact on thyroid homeostasis which results in change of thyroid function and thyroid volume (TV). Moreover, calcitonin (CT), and its gene-related peptide have been demonstrated to play an important role in the implantation process.

    Purpose: To evaluate changes in TV and serum CT levels during pregnancy. Read More

    Malignant melanoma with synchronous thyroid metastases: case report and literature review.
    Arch Endocrinol Metab 2017 Feb 16. Epub 2017 Feb 16.
    Department of Endocrinology, Diabetes and Metabolism, Faculty of Medicine University of Porto, Centro Hospitalar São João, Porto, Portugal.
    Thyroid metastases are rare in clinical practice. We describe the case of an 85-year-old woman who was referred to our department due to a multinodular goiter with compressive symptoms and subclinical hyperthyroidism. The patient was also undergoing evaluation for a polyp in her left nasal cavity, which was then diagnosed as a malignant melanoma of the nasal mucosa. Read More

    Iodine deficiency status in the WHO Eastern Mediterranean Region: a systematic review.
    Environ Geochem Health 2017 Feb 21. Epub 2017 Feb 21.
    Cellular and Molecular Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
    Iodine deficiency is a global public health issue because iodine plays a major role in the thyroid hormone synthesis and is essential for normal neurological development. This review summarizes the publications on iodine status in the WHO Eastern Mediterranean Region (EMR) countries. All related studies available in main national and international databases were systematically searched using some specific keywords to find article published between 1909 and 2015. Read More

    Exome sequencing identifies SLC26A4, GJB2, SCARB2 and DUOX2 mutations in 2 siblings with Pendred syndrome in a Malaysian family.
    Orphanet J Rare Dis 2017 Feb 21;12(1):40. Epub 2017 Feb 21.
    UKM Medical Molecular Biology Institute (UMBI), Chancellor Tuanku Muhriz Hospital, UKM Medical Centre, Jalan Yaacob Latif, 56000 Cheras, Kuala Lumpur, Malaysia.
    Background: Pendred syndrome (PDS, MIM #274600) is an autosomal recessive disorder characterized by congenital sensorineural hearing loss and goiter. In this study, we describing the possible PDS causal mutations in a Malaysian family with 2 daughters diagnosed with bilateral hearing loss and hypothyroidism.

    Methods And Results: Whole exome sequencing was performed on 2 sisters with PDS and their unaffected parents. Read More

    Identification of somatic and germ-line DICER1 mutations in pleuropulmonary blastoma, cystic nephroma and rhabdomyosarcoma tumors within a DICER1 syndrome pedigree.
    BMC Cancer 2017 Feb 21;17(1):146. Epub 2017 Feb 21.
    Laboratorio de Oncología Molecular, Instituto Universitario de Oncología del Principado de Asturias (IUOPA), AGC Laboratorio de Medicina, Hospital Universitario Central de Asturias (HUCA), Oviedo, 33011, Spain.
    Background: DICER1 syndrome is a pediatric cancer predisposition condition causing a variety of tumor types in children and young adults. In this report we studied a family with two relatives presenting a variety of neoplastic conditions at childhood.

    Methods: Germ-line mutation screening of the complete coding region of the DICER1 gene in genomic DNA from the proband was performed. Read More

    Decreased Frequencies of Peripheral Blood CD4+CD25+CD127-Foxp3+ in Patients with Graves' Disease and Graves' Orbitopathy: Enhancing Effect of Insulin Growth Factor-1 on Treg Cells.
    Horm Metab Res 2017 Feb 21. Epub 2017 Feb 21.
    Department of Nuclear Medicine, Medical University of Bialystok, Bialystok, Bialystok, Poland.
    Graves' orbitopathy (GO) is characterized by orbital T cell infiltration. We evaluated the regulatory T (Treg) cell fractions induced with IGF-1 in Graves' disease (GD) with and without GO. Peripheral blood mononuclear cells (PBMCs) were obtained from 13 patients with GD without eye manifestations; 10 patients with active GO; and 12 patients with nodular goiter (NG). Read More

    MST-4 and TRAF-6 expression in the peripheral blood mononuclear cells of patients with Graves' disease and its significance.
    BMC Endocr Disord 2017 Feb 20;17(1):11. Epub 2017 Feb 20.
    Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, No.1 Youyi Street, Yuzhong District, Chongqing, 400016, China.
    Background: MST-4 and TRAF-6 are involved in the regulation of inflammatory and immune responses. However, whether they participate in the pathogenesis of Graves' disease (GD) has not yet been reported. Therefore, the purpose of this study was to investigate the expression of MST-4 and TRAF-6 in the peripheral blood of patients with GD to understand their role in the pathogenesis of GD. Read More

    Improving iodine nutritional status and increasing prevalence of autoimmune thyroiditis in children.
    Indian J Endocrinol Metab 2017 Jan-Feb;21(1):85-89
    Department of Pediatrics, CSI Hospital, Bengaluru, Karnataka, India.
    Objective: The objective of this study is to evaluate the link between excess iodine intake as evidenced by increased urinary iodine excretion (UIE) and autoimmune thyroiditis in children and to assess the correlation between UIE and thyroid microsomal antibody (thyroid peroxidase [TPO]) titers in children.

    Materials And Methods: All children with goiter between age group 6 and 12 years, were subjected to blood tests for free thyroxine, thyroid stimulating hormone, and TPO antibody, fine needle aspiration was advised for all children with goiter. Forty-three children with confirmed autoimmune thyroiditis served as cases, and 43 children with euthyroid goiter with workup negative for autoimmune thyroiditis and iodine deficiency were enrolled as controls. Read More

    Usefulness of pre- and post-operative calcium and Vitamin D supplementation in prevention of hypocalcemia after total thyroidectomy: A randomized controlled trial.
    Indian J Endocrinol Metab 2017 Jan-Feb;21(1):51-55
    Department of Endocrinology, Sher-I-Kashmir Institute of Medical Sciences, Srinagar, Jammu and Kashmir, India.
    Background: Total thyroidectomy (TT) is a commonly performed surgery and postoperative hypocalcemia is a major detriment to early discharge. The aim of this randomized controlled trial was to ascertain the usefulness of routine pre- and post-operative calcium and Vitamin D supplementation in prevention of hypocalcemia after TT.

    Materials And Methods: Sixty consecutive patients who underwent total or near TT from February 2013 to August 2014 were included in the study. Read More

    Left parapharyngeal ectopic goitre associated with eutopic thyroid and postoperative Horner's syndrome.
    Eur Ann Otorhinolaryngol Head Neck Dis 2017 Feb 16. Epub 2017 Feb 16.
    Service d'ORL et chirurgie cervicofaciale, CHU Sylvanus Olympio, BP 57, Lomé, Togo.
    Introduction: The authors report a case of left parapharyngeal ectopic goitre, in which resection was followed by postoperative Horner's syndrome, and describe the difficult management of this entity.

    Case Report: A 25-year-old woman presented with upper oesophageal dysphagia and a well-demarcated left parapharyngeal mass displacing the great vessels laterally and posteriorly. The mass was resected via an exploratory neck incision. Read More

    Factors affecting sustainable iodine deficiency elimination in Pakistan: A global perspective.
    J Epidemiol 2017 Feb 16. Epub 2017 Feb 16.
    Institute for Community Medicine, Walther-Rathenau Str. 48, Ernst Moritz Arndt University, D-17475, Greifswald, Germany; DZHK (German Centre for Cardiovascular Research), Partner Site, University Greifswald, Germany.
    Iodine deficiency remains a considerable challenge worldwide, even after decades of efforts to address the problem. The aim of this review is to present the current situation in historically iodine-deficient Pakistan regarding iodine nutritional status and place it in a global perspective. We collected relevant articles from online bibliographic databases and websites of concerned organizations that addressed prevalence of goiter/iodine deficiency and barriers to sustainable control. Read More

    Metformin and thyroid disease.
    J Endocrinol 2017 Apr 14;233(1):R43-R51. Epub 2017 Feb 14.
    Affiliated Hospital of Integrated Traditional Chinese and Western MedicineNanjing University of Chinese Medicine, Jiangsu Province Academy of Traditional Chinese Medicine, Nanjing, China
    An intriguing area of research in thyroidology is the recently discovered association of insulin resistance with thyroid functional and morphological abnormalities. Individuals with hyperinsulinemia have larger thyroid gland and a higher prevalence of thyroid nodules and cancer. Accordingly, patients treated with metformin have a smaller thyroid volume and a lower risk of incident goiter, thyroid nodule and cancer. Read More

    Primary Thyroid Lymphoma: Clinicopathologic Characteristics and Therapeutic Outcomes of Six Cases in Morocco.
    • Authors:
    Gulf J Oncolog 2016 Sep;1(22):11-15
    Background: Primary non-Hodgkin lymphomas of the thyroid are uncommon and account for 1-5% of all thyroid malignancies and less than 2% of extranodal lymphomas. The aim of the present study was to review our experience and management of primary thyroid lymphoma and to discuss the diagnostic and therapeutic considerations.

    Methods: All non-Hodgkin lymphoma diagnosed at our institution between 2007 and 2011 were reviewed, six cases of primary thyroid lymphoma were identified. Read More

    Diffuse Follicular Variant of Papillary Thyroid Carcinoma: A Case Report with a Revision of Literature.
    Rare Tumors 2016 Nov 20;8(4):6536. Epub 2016 Dec 20.
    Department of Pathology, Sant'Andrea Hospital, University Sapienza of Rome , Italy.
    The diffuse follicular variant of papillary thyroid carcinoma (DFV-PTC) is a rare malignant thyroid condition. It represents an uncommon variant of papillary carcinoma characterized by a diffuse involvement of thyroid parenchyma, follicular architecture and nuclear features of PTC in absence of a surrounding capsule. Up to date few data have been collected about this entity and, at the best of our knowledge, only 24 cases have been reported in the literature. Read More

    Low Iodine in the Follicular Lumen Caused by Cytoplasm Mis-localization of Sodium Iodide Symporter may Induce Nodular Goiter.
    Biol Trace Elem Res 2017 Feb 12. Epub 2017 Feb 12.
    Department of Endocrinology, The Second Affiliated Hospital of Fujian Medical University, No. 34 North Zhongshan Road, Quanzhou, Fujian, 362000, People's Republic of China.
    Iodine is a key ingredient in the synthesis of thyroid hormones and also a major factor in the regulation of thyroid function. A local reduction of iodine content in follicular lumen leads to overexpression of local thyroid-stimulating hormone receptor (TSHr), which in turn excessively stimulates the regional thyroid tissue, and result in the formation of nodular goiter. In this study, we investigated the relationship between iodine content and sodium iodide symporter (NIS) expression by using the clinical specimens from patients with nodular goiter and explored the pathogenesis triggered by iodine deficiency in nodular goiter. Read More

    Perioperative determinants of transient hypocalcemia after pediatric total thyroidectomy.
    J Pediatr Surg 2017 Jan 27. Epub 2017 Jan 27.
    Division of Pediatric Surgery, Department of Surgery, Texas Children's Hospital and Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX 77030. Electronic address:
    Purpose: We seek to identify risk factors associated with hypocalcemia after pediatric total thyroidectomy.

    Methods: We retrospectively reviewed patients younger than 21years undergoing total thyroidectomy between January 2002 and January 2016. We defined hypocalcemia as any serum calcium <8mg/dl or ionized calcium <1. Read More

    How "suspicious" is that nodule? Review of "suspicious" Afirma gene expression classifier in high risk thyroid nodules.
    Diagn Cytopathol 2017 Apr 11;45(4):308-311. Epub 2017 Feb 11.
    Department of Pathology, Hofstra Northwell Health School of Medicine, Lake Success, New York.
    Background: The Afirma gene expression classifier (GEC) is being increasingly utilized to confirm the benign nature of indeterminate FNA cytology results thus avoiding unnecessary surgical procedures. However the "suspicious" result of the Afirma GEC does not classify these indeterminate nodules further in determining appropriate management. This study investigated the outcome of the thyroid nodules deemed to be "suspicious" by the Afirma GEC in a high risk population. Read More

    Treatment by rituximab on six Grave's ophthalmopathies resistant to corticosteroids.
    Ann Endocrinol (Paris) 2017 Feb 6;78(1):20-26. Epub 2017 Feb 6.
    Service d'ophtalmologie, hôpital Bretonneau, centre hospitalier universitaire de Tours, 2, boulevard Tonnellé, 37044 Tours cedex 9, France; Faculté de médecine de Tours, 10, boulevard Tonnellé, BP 3223, 37032 Tours cedex 1, France.
    Objectives: Graves' ophthalmopathy occurs in 50% of Graves' disease cases. Treatment is based on smoking cessation, and control of the euthyroidism and ocular repercussions associated with the disease. The active orbital forms are treated with glucocorticoids. Read More

    Transoral Endoscopic Thyroidectomy Vestibular Approach (TOETVA): From A to Z.
    Surg Technol Int 2017 Feb 7;30. Epub 2017 Feb 7.
    Minimally Invasive and Endocrine Surgery Division, Department of Surgery Police General Hospital, Bangkok, Thailand.
    We depict the transoral endoscopic thyroidectomy vestibular approach (TOETVA). Patient selection criteria are (1) ultrasonographically (US) estimated thyroid diameter no larger than 10cm, (2) US estimated gland volume ≥45mL, (3) nodule size ≥5mm, (4) a benign tumor, such as a thyroid cyst, single-nodular goiter, or multinodular goiter, (5) follicular neoplasm, and (6) papillary microcarcinoma without evidence of metastasis. TOETVA is carried out through a three-port technique placed at the oral vestibule, one 10mm port for 30° endoscope and two additional 5mm ports for dissecting and coagulating instruments. Read More

    Association between single nucleotide variants of vascular endothelial growth factor a and the risk of thyroid carcinoma and nodular goiter in a Han Chinese population.
    Oncotarget 2017 Feb 2. Epub 2017 Feb 2.
    Department of Epidemiology and Biostatistics, School of Public Health, Jilin University, Changchun 130021, China.
    The aim of the present study was to investigate whether genetic variants in the vascular endothelial growth factor A gene (VEGFA) were risk factors for papillary thyroid carcinoma (PTC) or nodular goiter (NG) in Han Chinese. A total of 2,319 subjects (861 PTC patients, 562 NG patients, and 896 healthy controls) were included. Five tag single nucleotide polymorphisms (tagSNPs: rs3024997, rs3025040, rs833070, rs25648, and rs10434) in VEGFA were genotyped. Read More

    A new method of subtotal thyroidectomy for Graves' disease leaving a unilateral remnant based on the upper pole.
    Medicine (Baltimore) 2017 Feb;96(6):e5919
    aDepartment of Thyroid and Breast Surgery bInstitute of Orthopedics, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
    Background: The aim of this prospective randomized study was to evaluate the feasibility of subtotal thyroidectomy with leaving a unilateral remnant based on the upper pole.

    Methods: Patients who underwent the subtotal thyroidectomy and isthmusectomy leaving either a unilateral remnant based on the upper pole (Group I, 79 patients) or the bilateral dorsal thyroid tissue remained (Group II, 89 patients) were compared in operation time, blood loss, recurrence, and postoperative complications.

    Results: Among 168 patients analyzed, the operation time remained similar, but the blood loss, the reoperation time, and recurrence in Group I were much less than Group II. Read More

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