Search Our Scientific Publications & Authors

Vopr Pitan 2018 13;87(5):27-36. Epub 2018 Sep 13.

Industrial University of Tyumen.

Iodine supply remains the global problem due to the wide prevalence and a wide range of clinical manifestations in all age groups of population. However, iodine deficiency is a nutritional deficiency and the solution of this problem lies in the organization of rational nutrition of the population. The purpose of this study was to examine the food features of the population of the mild iodine-deficient region from the standpoint of adequacy of iodine sufficiency. Read More

Thyroid 2019 Feb 15. Epub 2019 Feb 15.

School of Medicine. University of Seville, Citología e Histología Normal y Patológica, Seville, Spain ;

Background: Primary cilia (PC) are conserved structures in the adult thyroid gland of different mammals. We have recently described that, in humans, PC are usually present as a single copy per follicular cell emerging from the follicular cell apex into the follicular lumen.

Methods: To better understand the role developed by PC in thyroid hormonogenesis, we investigated their changes in different human functional thyroid diseases (diffuse toxic hyperplasia/Graves' disease and nodular hyperplasia/nodular goiter), in comparison with normal thyroid tissue, using immunofluorescence, morphometry and electron microscopy analyses. Read More

Indian J Endocrinol Metab 2018 Nov-Dec;22(6):793-797

Department of Endocrine Surgery, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Raebareli Road, Lucknow, Uttar Pradesh, India.

Introduction: Anaplastic thyroid cancers (ATCs) usually present in the sixth to seventh decades of life and little is known about the disease in young patients. The aim was to analyze the clinicopathological characteristics diagnosed with ATC in an iodine-deficient area.

Material And Methods: The medical records of 100 patients diagnosed with ATC at a tertiary care hospital between 1991 and 2013 were reviewed. Read More

Clin Nucl Med 2019 Feb 8. Epub 2019 Feb 8.

From the Clinic of Nuclear Medicine, Jena University Hospital, Jena, Germany.

A 49-year-old woman presented with a multinodular goiter, causing local symptoms and hyperthyroisdism. Besides a hypofunctioning benign nodule (TIRADS 3, benign in FNAC), the conventional diagnostic revealed another small hyperfunctioning nodule with suspicious ultrasound features (TIRADS 4C). To rule out a trapping-only nodule and topographical misalignments, a I PET/ultrasound fusion was performed and confirmed elevated iodine uptake within the suspicious nodule. Read More

Orphanet J Rare Dis 2019 Feb 13;14(1):42. Epub 2019 Feb 13.

CHU Lille, Endocrinology, Diabetology and Metabolism, F-59000, Lille, France.

Background: Myotonic dystrophy (DM1), a neuromuscular disease related to DMPK gene mutations, is associated to endocrine disorders and cancer. A routine endocrine work-up, including thyroid ultrasound (US), was conducted in 115 genetically-proven DM1 patients in a neuromuscular reference center. The aim of this study was to determine the prevalence and the causes of US thyroid abnormalities in DM1. Read More

Horm Metab Res 2019 Feb 13;51(2):127-133. Epub 2019 Feb 13.

Department of Production, Research, and Innovation, Region Zealand, Sorø, Denmark.

We have previously reported decreased thyroid function within the laboratory reference range and changes in mitochondrial function after hemithyroidectomy. Peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α) and coactivator-1β (PGC-1β) are key regulators of mitochondrial biogenesis and function. The aim was to examine the influence of hemithyroidectomy on the longitudinal change in mRNA expression of these genes. Read More

Eur J Case Rep Intern Med 2018 27;5(12):000999. Epub 2018 Dec 27.

Internal Medicine Department, Centro Hospitalar e Universitário de Coimbra, Portugal.

Primary thyroid lymphoma is a rare cause of both thyroid malignancy and extra-nodal lymphoma. It typically presents as a rapidly enlarging goitre with compressive symptoms. Histological analysis of a biopsy specimen is necessary to confirm the diagnosis. Read More

Mol Diagn Ther 2019 Feb 11. Epub 2019 Feb 11.

Department of Biomedicine and Genetics, Medical University of Lodz, Pomorska 251 St, 92-213, Lodz, Poland.

Background: Loss of heterozygosity (LOH) and microsatellite instability (MSI) are frequent molecular events in thyroid tumor etiopathogenesis occurring in several chromosomal critical areas, including 3p12-25.3, 7q21-31, 10q22-24, and 15q11-13, with loci of tumor suppressor genes.

Objective: We evaluated the usefulness of LOH/MSI as a diagnostic/prognostic biomarker in lesions derived from thyroid follicular cells: follicular thyroid carcinoma (FTC); follicular adenoma (FA), papillary thyroid carcinoma (PTC), and nodular goiter (NG). Read More

Cochrane Database Syst Rev 2019 Feb 12;2:CD010734. Epub 2019 Feb 12.

Office of the Chief Scientist, The George Institute for Global Health, University of New South Wales, Sydney, Australia.

Background: Iodine deficiency disorders (IDD) affect close to 1.9 billion people worldwide, and are a major public health concern in many countries. Among children, iodine deficiency is the main cause of potentially preventable deficits of central nervous system development and impairment of cognitive function, as well as goitre and hypothyroidism in people of all ages. Read More

Clin Endocrinol (Oxf) 2019 Feb 11. Epub 2019 Feb 11.

Department of Nuclear Medicine and Thyroid Centre, Oncology Institute of Southern Switzerland, Bellinzona, Switzerland.

Background: Several ultrasound (US) risk stratification systems have been proposed for the assessment of thyroid nodules, and their performance was shown as good. However, the rate of nodules assessed at intermediate risk is not negligible and whether they should be submitted or not to further examination is still under debate. The present study aimed to evaluate the reliability of F-FDG PET/CT in stratifying the risk of malignancy in these lesions. Read More

Proc Nutr Soc 2019 Feb 11:1-13. Epub 2019 Feb 11.

Department of Nutritional Sciences,College of Human Sciences, Texas Tech University,Texas,USA.

Iodine is an essential trace mineral, vital for its functions in many physiological processes in the human body. Both iodine deficiency (ID) and excess are associated with adverse health effects; ID and excess iodine intake have both been identified in sub-Saharan Africa (SSA). The review aims to (1) review the iodine status among populations in SSA until October 2018, and (2) identify populations at risk of excess or inadequate iodine intakes. Read More

World J Pediatr 2019 Feb 8. Epub 2019 Feb 8.

Department of Medicine, The University of Calgary, Calgary, AB, Canada.

Background: Thyroid hormones are critical for early neurocognitive development as well as growth and development throughout childhood. Prompt recognition and treatment of hypothyroidism is, therefore, of utmost importance to optimize physical and neurodevelopmental outcomes.

Data Sources: A PubMed search was completed in Clinical Queries using the key terms "hypothyroidism". Read More

J Trace Elem Med Biol 2019 Mar 10;52:6-11. Epub 2018 Nov 10.

Department of Environmental Health Engineering, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran; Center for Air Pollution Research (CAPR), Institute for Environmental Research (IER), Tehran University of Medical Sciences, Tehran, Iran; Centre for Water Quality Research (CWQI), Institute for Environmental Research (IER), Tehran University of Medical Sciences, Tehran, Iran. Electronic address:

Iodine deficiency disorders include a wide range of metabolic and nonmetabolic disorders including goiter. To control IDDs, the World Health Organization and responsible agencies in countries established daily iodine uptake. Almost all the countries in the world provide the required iodine through salt iodisation. Read More

Evid Based Complement Alternat Med 2019 6;2019:5645620. Epub 2019 Jan 6.

Beijing University of Chinese Medicine, No. 11 East Road, North 3rd Ring Road, Chaoyang District, Beijing 100029, China.

species combined with is a famous herbal pair in traditional Chinese medicine, as one of the so-called "eighteen antagonistic medicaments." In the Chinese Pharmacopoeia, two different species of , and , are recorded but they are not clearly differentiated in clinical use. In this study, we aimed to determine whether the two species of could result in different effects when combined with in Haizao Yuhu Decoction (HYD), which is used for treating thyroid-related diseases, especially goiter. Read More

J BUON 2018 Dec;23(7):139-143

Department of Endocrinology, Metaxa Cancer Hospital, Piraeus, Greece.

Purpose: Thyroid nodular disease (TND) is a frequent clinical problem and the major concern is the probability of malignancy in a solitary nodule or in one or more nodules of a multinodular goiter. For this purpose, neck ultrasound and fine needle aspiration biopsy (FNAB) under ultrasound guidance have been established as the initial investigation of choice.

Methods: A total of 1113 patients (210 male/903 female) underwent FNABs for the same number of thyroid nodules. Read More

Endocr Pract 2019 Jan 18. Epub 2019 Jan 18.

From: 1Shanghai Clinical Center for Endocrine and Metabolic Diseases, Department of Endocrinology, The Ruijin Hospital of Shanghai Jiao-Tong University, Shanghai, China.

Objective: Epidemiologic studies on the relationship between iodine and thyroid antibodies were inconsistent. Iodine nutrition, genetic and environmental factors have been shown to modify the effects of iodine on thyroid autoimmunity. We investigated the relationship between urinary iodine concentration (UIC) and thyroglobulin antibodies (TgAb) in individuals living in iodine sufficient areas in this cross-sectional study. Read More

Nutrients 2019 Feb 3;11(2). Epub 2019 Feb 3.

Department of Medical Sciences, University of Turin, 10126 Turin, Italy.

Medical nutritional therapy is the first-line approach in managing gestational diabetes mellitus (GDM). Diet is also a powerful modulator of the gut microbiota, whose impact on insulin resistance and the inflammatory response in the host are well known. Changes in the gut microbiota composition have been described in pregnancies either before the onset of GDM or after its diagnosis. Read More

J Pediatr Endocrinol Metab 2019 Feb;32(2):143-149

UGC Emeritus Professor, Endocrinology and Reproductive Physiology Laboratory, Department of Physiology, University College of Science and Technology, University of Calcutta, 92, A.P.C. Road, Kolkata - 700 009, West Bengal, India.

Background To compare the state of iodine nutrition among school age children (SAC) in high- (HSGs) and low-socioeconomic groups (LSGs) during a post iodation scenario in Kolkata. Methods Clinical examinations of the goiter, median urinary iodine (MUI), mean urinary thiocyanate (MUSCN) in SAC (6-12 years) from both sexes in the different socioeconomic groups were carried out and the iodine content of edible salt was measured. Results A total of 5315 SAC, of which 2875 SAC were from a HSG and another 2440 SAC from an LSG were clinically examined for goiter. Read More

J Endocrinol Invest 2019 Feb 1. Epub 2019 Feb 1.

Biocruces Health Research Institute, Cruces University Hospital, CIBERER, CIBERDEM, UPV-EHU, Barakaldo, Basque Country, Spain.

Objective: Thyroid hormone resistance (RTH β) is a rare genetic disorder characterized by an altered response of target tissue to the action of thyroid hormone. Few studies on RTH β have been carried out in southern European populations. We aimed to describe the clinical and genetic characteristics at the time of diagnosis in a Spanish cohort of patients with genetically confirmed RTH β, with ages ranging from newborns to adults. Read More

Am J Case Rep 2019 Feb 1;20:134-138. Epub 2019 Feb 1.

Department of Surgical Oncology, HCG Manavata Cancer Centre, Nashik, Maharashtra, India.

BACKGROUND Anaplastic thyroid carcinoma (ATC) is an uncommon and aggressive form of human cancer. Despite advancement in multimodal therapy for patients with ATC, the prognosis remains poor. Most patients presenting with ATC have metastasis to the lungs and regional lymph nodes. Read More

Endocrinol Diabetes Metab Case Rep 2019 Jan 31;2019. Epub 2019 Jan 31.

Centre for Endocrine and Diabetes Sciences, University Hospital of Wales, Cardiff, UK.

Thymic enlargement (TE) in Graves' disease (GD) is often diagnosed incidentally when chest imaging is done for unrelated reasons. This is becoming more common as the frequency of chest imaging increases. There are currently no clear guidelines for managing TE in GD. Read More

Endocrinol Diabetes Metab Case Rep 2019 Jan 31;2019. Epub 2019 Jan 31.

1st Department of Internal Medicine, AHEPA University Hospital, Thessaloniki, Greece.

Pseudohypoparathyroidism (PHP) is a heterogeneous group of rare endocrine disorders characterised by normal renal function and renal resistance to the action of the parathyroid hormone. Type 1A (PHP1A), which is the most common variant, also include developmental and skeletal defects named as Albright hereditary osteodystrophy (AHO). We present two cases, a 54- and a 33-year-old male diagnosed with PHP who were referred to us for persistently high levels of serum calcitonin. Read More

Medicine (Baltimore) 2019 Feb;98(5):e14351

Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Rationale: Cystic parathyroid adenomas are rare and seldom arise in ectopically located glands which may be found within the carotid sheath, mediastinum, thymus, or thyroid grand. They cannot be detected consistently by any imaging methods. Unusual symptoms may bring about certain pitfalls and difficulties for the diagnosis of primary hyperparathyroidism (PHPT) caused by cystic parathyroid adenomas. Read More

Ter Arkh 2018 Nov;90(10):4-23

Medical Research Center of Endocrinology, Ministry of Health of Russia, Moscow, Russia.

Since the middle of the twentieth century, there has been a significant change in methods of the diagnosis and treatment of thyroid diseases with thyrotoxicosis syndrome. Previously doctors did not have trouble just with diagnosing diseases that occur with a typical clinical presentation (the Merzeburg triad, a multinodal goiter with fibrillation) because of no possible to determine thyroid hormones. Then in the early 70s years the appearance of immunological methods for estimating hormones in the blood has led to significant changes in our understanding of the variants of thyroid pathology with thyrotoxicosis (TT). Read More

Ethiop J Health Sci 2019 Jan;29(1):887-894

Department of Internal Medicine, Cardiology Unit, St. Paul's Hospital Millennium Medical College, Addis Ababa, Ethiopia.

Background: Thyro-cardiac disease describes the existence of a combination of thyroid toxicity and significant heart disease in an individual patient. The frequent manifestations of thyro-cardiac disease are hypertension, atrial flutter or fibrillation, pulmonary hypertension and dilated cardiomyopathy. The aim of the study was to determine the pattern and presentation of cardiovascular diseases in patients with hyperthyroidism on follow-up at St. Read More

Biol Open 2019 Jan 30. Epub 2019 Jan 30.

Division of Cell Matrix Biology & Regenerative Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester M13 9PT, UK

Thyroid dyshormonogenesis is a leading cause of congenital hypothyroidism, a highly prevalent but treatable condition. Thyroid hormone synthesis is dependent on the formation of reactive oxygen species (ROS). In humans, the primary sources for ROS production during thyroid hormone synthesis are the NADPH oxidases DUOX1 and DUOX2. Read More

BMC Emerg Med 2019 Jan 29;19(1):18. Epub 2019 Jan 29.

Department of anesthesiology and critical care, Military Hospital Mohamed V, Faculty of medicine and pharmacy, university of Mohamed V Souissi, Rabat, Morocco.

Background: Pregnancy constitutes a significant factor in thyroid hypertrophy and can rarely progress to respiratory distress. We describe case of pregnant woman with acute respiratory distress following a tracheal compression due to goiter, quickly resulting in respiratory arrest, requiring emergency orotracheal intubation and thyroidectomy.

Case Presentation: A pregnant woman with a growing goiter was referred to the hospital with a respiratory difficulty. Read More

Thyroid 2019 Jan 30. Epub 2019 Jan 30.

Tianjin Medical University, School of Public Health , 22 Qixiang Tai Road, Heping District , Tianjin, China , 300070 ;

Background: The iodine nutritional status of the Chinese population has been greatly improved in recent years. Therefore, the reference values for thyroid volume (Tvol) in children with sufficient iodine intake need to be updated. The study aimed to update the reference values for Tvol in children with sufficient iodine intake, in order to define goiter in the context of sustained iodine sufficiency. Read More

Medicina (B Aires) 2019 ;79(1):11-19

1Laboratorio de Endocrinología, Instituto de Fisiología, Facultad de Medicina, Universidad de Buenos Aires, Argentina. E-mail:

Subclinical hypothyroidism (SH), elevation of the level of thyrotrophin with normal thyroid hormones, along with goiter (glandular size > 25g), increased in recent decades. In order to relate the prevalence of goiter and SH with the consumption of groundwater, as a population etiological risk factor, we analyzed 879 clinical histories from a medical center in the city of Glew in the South Buenos Aires suburbs. The population was studied according to age (20 to 60 and 12 to 19 years) and type of water consumed (potable water or groundwater). Read More

Gan To Kagaku Ryoho 2018 Dec;45(13):2114-2116

Dept. of Surgery, Tokyo Metropolitan Otsuka Hospital.

We describe 14 resected cases of thyroid tumor diagnosed as Class Ⅲ by fine needle aspiration cytology(FNA). Of these, 13 cases were diagnosed as: malignant tumor(1 case), suspicion of malignant tumor(5 cases), or were hard to distinguish from benign or malignant(7 cases). The operative methods used were total or near total thyroidectomy plus D1 or D2a in 4 cases; hemithyroidectomy plus D1 in 3 cases; subtotal thyroidectomy in 3 cases; and lobectomy of the thyroid in 4 cases. Read More

Cir Esp 2019 Feb 26;97(2):81-88. Epub 2019 Jan 26.

Department of Surgery, Mount Sinai Hospital, New York, NY, USA.

Introduction: The extracervical approach for thyroidectomy remains widely unknown in our country. Its main aim is to avoid a cervical scar while maintaining the same safety profile of conventional thyroidectomy. The objective is to communicate our experience after the first 15 cases using the endoscopic bilateral axillo-breast approach (BABA) and to review critical points described in literature. Read More

Ultrasonography 2018 Nov 9. Epub 2018 Nov 9.

Department of Surgery, The University of Hong Kong, Hong Kong SAR, China.

High-intensity focused ultrasound (HIFU) is a promising ablation technique for benign thyroid nodules. Current evidence has found good short- to medium-term outcomes, similar to those of better-established ablation techniques such as radiofrequency and laser ablation. The fact that it does not require insertion of a needle into the target makes HIFU a truly non-invasive treatment. Read More

J Trop Pediatr 2019 Jan 23. Epub 2019 Jan 23.

Human Nutrition Unit, All India Institute of Medical Sciences, Ansari Nagar, Delhi, India.

Iodine deficiency disorder (IDD) is a major public health problem in India. We conducted this study to assess goitre prevalence, urinary iodine excretion (UIE) among school children and to determine iodine concentration in salt samples at consumer level, in Jabalpur district. We adopted "30 cluster" sampling, recommended by joint WHO/UNICEF/ICCIDD Consultation. Read More

Gene 2019 Jan 24;693:37-45. Epub 2019 Jan 24.

Department of Oncology, First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing 210029, Jiangsu Province, PR China; Department of Oncology, The Affiliated Jiangsu Shengze Hospital of Nanjing Medical University， No.1399 West Road, Shengze Town, Wujiang District, Suzhou 215000, China. Electronic address:

Whether plasma miRNAs could be used as novel non-invasive biomarkers in diagnosing papillary thyroid carcinoma (PTC) remains unknown. In this study, we designed a four-phase study to identify differentially expressed plasma miRNAs in Chinese PTC patients. Exiqon panel was initially utilized to conduct plasma miRNA profile (3 PTC pools VS. Read More

J Pediatr Endocrinol Metab 2019 Feb;32(2):203-206

Department of Pediatrics, Division of Pediatric Endocrinology, SUNY Downstate Medical Center, Brooklyn, NY, USA.

Background Resistance to thyroid hormone (RTH) commonly presents with goiter, attention deficit hyperactivity disorder (ADHD), short stature and tachycardia. However, due to its variable presentation with subtle clinical features, a third of the cases are mistreated, typically as hyperthyroidism. Case presentation A 15-year-old female with ADHD and oligomenorrhea was initially diagnosed as Hashimoto's thyroiditis but found to have a rare heterozygous mutation in c803 C>G (p Ala 268 Gly) in the THRβ gene, confirming resistance to thyroid hormone. Read More

Medicine (Baltimore) 2019 Jan;98(4):e14245

Department of Endocrinology, The Second Affiliated Hospital of Xuzhou Medical University, Xuzhou.

The aim of this study was to determine the trimester-specific reference range of thyroid function in Nanjing.A total of 805 pregnant women in the 1st, 2nd, and 3rd trimesters were recruited in the prospective, observational study during their routine antenatal clinic visit and 282 nonpregnant subjects served as controls. A questionnaire was completed by the subjects to record their personal health history, family history of thyroid disease, and consumption of estrogen or antithyroid drugs. Read More

JAMA Cardiol 2019 Jan 23. Epub 2019 Jan 23.

Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.

Importance: Thyroid hormone levels are tightly regulated through feedback inhibition by thyrotropin, produced by the pituitary gland. Hyperthyroidism is overwhelmingly due to thyroid disorders and is well recognized to contribute to a wide spectrum of cardiovascular morbidity, particularly the increasingly common arrhythmia atrial fibrillation (AF).

Objective: To determine the association between genetically determined thyrotropin levels and AF. Read More

Indian J Med Res 2018 Nov;148(5):539-547

Centre for Promotion of Nutrition Research and Training with special focus on North East, tribal & Inaccessible Population, Division of Nutrition, Indian Council of Medical Research (Campus II), Tuberculosis Association of India Building, New Delhi; ICMR-Desert Medicine Research Centre, Jodhpur, India.

The review on fluorosis addresses the genesis of the disease, diagnostic protocols developed, mitigation and recovery through nutritional interventions. It reveals the structural and functional damages caused to skeletal muscle and erythrocytes, leading to clinical manifestations in fluorosis. Hormonal derangements resulting in serious abnormalities in the health of children and adults are discussed. Read More

Indian J Med Res 2018 Nov;148(5):503-510

Indian Coalition for Control of Iodine Deficiency Disorders, All India Institute of Medical Sciences, New Delhi, India.

Iodine deficiency disorders (IDDs) constitute a significant public health problem globally. In India, the entire population is prone to IDDs due to deficiency of iodine in the soil of the sub-continent and thus both animal and plant source food grown on the iodine-deficient soil. IDDs encompass the spectrum of disability and disease and include goitre, cretinism, hypothyroidism, abortion, stillbirth, brain damage, learning disabilities, mental retardation, psychomotor defects, hearing and speech impairment. Read More

Am J Surg 2019 Jan 4. Epub 2019 Jan 4.

Servicio de Cirugía General y del Aparato Digestivo, Hospital Clínico Universitario Virgen de la Arrixaca, El Palmar, Murcia, Spain; Departamento de Cirugía, Facultad de Medicina, Universidad de Murcia, Instituto Murciano de Investigación Biosanitaria (IMIB), Murcia, Spain. Electronic address:

Background: Hypocalcemia is one of the most common complications after total thyroidectomy. Recently, indocyanine green (ICG) angiography of the parathyroid glands (PGs) has been suggested as a reliable tool for predicting postoperative hypocalcemia. The aim of our study was to evaluate the performance of a simple quantitative score based on ICG angiography of the PGs (4-ICG score) for predicting postoperative hypocalcemia. Read More

Case Rep Endocrinol 2018 19;2018:9564737. Epub 2018 Dec 19.

Pediatric Endocrinology Unit, Department of Pediatrics, Centro Materno Infantil do Norte-Centro Hospitalar Universitário do Porto, Oporto, Portugal.

Fetal goiter is a rare disorder not expected to be found during a healthy woman's pregnancy. It can be a prenatal manifestation of congenital hypothyroidism due to thyroid dyshormonogenesis and it can lead to serious perinatal complications. A vascularized fetal neck mass was detected at 29 weeks' gestation of a healthy primigravida. Read More

Eur J Obstet Gynecol Reprod Biol 2019 Jan 9;234:43-48. Epub 2019 Jan 9.

Department of Internal Medicine and Clinical Pharmacology, Medical University of Silesia, Katowice, Poland.

Objective: Despite high prevalence in a female population, surprisingly little is known about sexual functioning of women with thyroid hyperfunction. This study was aimed at assessing female sexual function and depressive symptoms in women with overt hyperthyroidism of autoimmune and non-autoimmune origin.

Study Design: The study included three age-matched groups of young women inhabiting the Upper Silesia (a selenium-deficient and iodine-sufficient area): individuals with overt hyperthyroidism induced by Graves' disease (group A, n = 31), women with overt hyperthyroidism caused by toxic multinodular goiter or toxic adenoma (group B, n = 30) and women with normal thyroid function (group C, n = 34). Read More

Medicine (Baltimore) 2019 Jan;98(3):e14162

Department of Ophthalmology, the First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi.

In this study, we try to explore the effect of orbital decompression treatment on severe dysthyroid optic neuropathy.We retrospectively collected demographic and clinical characteristics of thyroid eye disease patients who performed orbital decompression. Then we analyzed the change of best-corrected visual acuity and exophthalmometry after surgery and the correlations among clinical parameters. Read More

J Formos Med Assoc 2019 Jan 7;118(1 Pt 3):387-394. Epub 2018 Jul 7.

Department of Ophthalmology, National Taiwan University Hospital, Taipei, Taiwan; School of Medicine, National Taiwan University, Taipei, Taiwan. Electronic address:

Background/purpose: To compare the outcomes of strabismus surgery in patients with Graves' ophthalmopathy (GO) who had undergone bone removal orbital decompression (BROD) or fat removal orbital decompression (FROD) with those who had not undergone any orbital decompression.

Methods: The records of patients with GO who underwent strabismus surgery over a period of 66 months were retrospectively reviewed.

Results: Eighty-nine patients with a mean age of 55. Read More

Autoimmun Rev 2019 Jan 11. Epub 2019 Jan 11.

Department of Clinical and Experimental Medicine, University of Pisa, Via Savi 10, Pisa 56126, Italy. Electronic address:

Graves' disease (GD) and autoimmune thyroiditis (AT) are the two main clinical presentations of AITD, and their clinical hallmarks are thyrotoxicosis and hypothyroidism, respectively. GD, and AT, can be associated with other organ specific, or systemic autoimmune diseases in the same patient. However discordant results have been reported in the literature about the possible associations. Read More

Indian J Pediatr 2019 Feb 12;86(2):113-115. Epub 2019 Jan 12.

Department of Pediatrics, Jaber Al-Ahmed Armed Forces Hospital, Kuwait City, Kuwait.

J Gen Fam Med 2019 Jan 24;20(1):37-38. Epub 2018 Nov 24.

Department of General Medicine Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Okayama Japan.

Marine-Lenhart syndrome is rare disease defined as coexistence of Graves' disease and autonomously functioning thyroid nodule. We will introduce a case of Marine-Lenhart with a huge goiter. Read More

J Endocrinol Invest 2019 Jan 9. Epub 2019 Jan 9.

Accademia Peloritana dei Pericolanti, University of Messina, Messina, Italy.

Arch Endocrinol Metab 2018 ;62(6):609-614

Department of Endocrinology, CHU, Liège, Belgium.

Objective: The conversion of Hashimoto's thyroiditis (HT) to hyperthyroidism due to thyrotropin receptor antibodies is intriguing and considered rare. The contribution of TSH receptor blocking antibodies (TRAb), which may be stimulators (TSAb) or blockers (TBAb), is suspected. We describe clinical and biological variables in a series of patients switching from Hashimoto's thyroiditis to Grave's disease. Read More

BMC Ophthalmol 2019 Jan 8;19(1). Epub 2019 Jan 8.

Department of Endocrinology, Metabolism and Internal Medicine, Poznan University of Medical Sciences, Przybyszewskiego 49, 60-355, Poznan, Poland.

Background: Thyroid-associated orbitopathy (TAO) constitutes an immune-mediated inflammation of the orbital tissues of unclear etiopathogenesis. TAO is most prevalent in hyperthyroid patients with Graves' disease (GD); however, severe cases of orbitopathy associated with Hashimoto's thyroiditis (HT) have rarely been described.

Case Presentation: Herewith we report an unusual case of a middle-aged clinically and biochemically euthyroid woman with a stable HT, who developed a severe unilateral left-sided TAO. Read More