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    Heterogeneity of tissue IL-17 and tight junction proteins expression demonstrated in patients with autoimmune thyroid diseases.
    Medicine (Baltimore) 2018 Jun;97(25):e11211
    Institute of Anatomy and Anthropology.
    Th17 cells together with their hallmark cytokine interleukin (IL)-17 were identified as crucial contributing factors in the pathogenesis of thyroid autoimmunity. The cytokine-regulated tight junction (Tj) disruption is thought to be essential in the initiation and/or development of several diseases. Still, the role of IL-17 maintaining Tj integrity in autoimmune thyroid diseases (AITDs) has not yet been evaluated. Read More

    The thyroid gland in ancient Greece: a historical perspective.
    Hormones (Athens) 2018 Jun 19. Epub 2018 Jun 19.
    Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece.
    Thyroidology is a discipline of Endocrinology which has evolved markedly over the past few decades. However, its historical roots can be seen in the literature of, among others, ancient Greek medicine. In the present article, we present the descriptions of the thyroid gland by ancient Greek physicians and its depiction in ancient Greek art. Read More

    Early Experience of Gasless Video-Assisted Neck Surgery (VANS) for Thyroid Nodules in Thailand.
    J Med Assoc Thai 2016 Jul;99 Suppl 4:S42-7
    Background: Endoscopic thyroidectomy has increased in popularity because of the good cosmesis. In Thailand, most endoscopic thyroidectomy surgeries are done with a gas technique, using CO2 insufflation to obtain a working space. The CO2 pressure has to be kept under control to prevent gas-related complications. Read More

    An investigation into symptoms, diagnosis, treatment, and treatment complications in patients with retrosternal goiter.
    J Family Med Prim Care 2018 Jan-Feb;7(1):224-229
    Inflammatory Lung Disease Research Center, School of Medicine, Razi Hospital, Guilan University of Medical Science, Rasht, Iran.
    Introduction: Retrosternal goiter refers to any thyroid enlargement in which over 50% of the thyroid permanently located under the thoracic inlet or the lower pole of thyroid is not palpable with the neck in hyperextended position. Due to the increasing number of surgical procedures of retrosternal goiter, the present study was carried out to examine the symptoms, diagnosis, treatment, and treatment complications in retrosternal goiter patients.

    Materials And Methods: Data related to demographic data (age and gender), clinical symptoms (dyspnea, dysphagia, dysphonia, lumps in neck, and hoarseness), methods of diagnosis (computed tomography [CT], chest X-ray [CXR], ultrasonography, and magnetic resonance imaging), and postoperative complications (bleeding, early and late dysphonia, early and late dyspnea, transient and permanent hypocalcemia, transient, and permanent recurrent laryngeal nerve paralysis) were collected. Read More

    Transient Hyperthyroidism Induced by Thyroid Ultrasound.
    Ann Otol Rhinol Laryngol 2018 Jun 1:3489418781169. Epub 2018 Jun 1.
    1 Section of Endocrinology and Metabolism, Department of Internal Medicine, Louisiana State University Health Sciences Center in Shreveport, Shreveport, Louisiana, USA.
    Objectives: Transient hyperthyroidism has been documented following surgical manipulation or direct trauma to the normal thyroid gland. This has best been studied in patients following parathyroidectomy and also reported following trauma to the neck, strangulation, and vigorous palpation of the thyroid gland. It has not previously been reported following a thyroid ultrasound. Read More

    The Goitrous Salting Madonnas: Iconography of Goiter in Religious Portraits.
    Indian J Endocrinol Metab 2018 Mar-Apr;22(2):283-286
    Department of Plastic and Reconstructive Surgery, University of Rome Tor Vergata, Rome, Italy.
    Introduction: George Salting was an art collector, who bequeathed his collection of paintings to the National Gallery of London. The present investigation has revealed five portraits of five different artists belonging to this collection in which the Holy Mother holding the child has been portrayed with a variable grade of thyroid gland enlargement. The name Salting, applied to the Madonnas with child by Antonello da Messina, Robert Campin, Dirk Bouts, Cima da Conegliano, and Andrea del Verrocchio, denotes George Salting, the collector who donated the masterworks to the gallery in 1910. Read More

    Georgian Med News 2018 May(278):103-107
    West Kazakhstan Marat Ospanov State Medical University, Aktobe, Republic of Kazakhstan.
    Aim of research - to study the iodine supply of the region according to the degree of urinary iodine excretion in the West region of the Republic of Kazakhstan. Of 6493 schoolchildren participating in the study of the frequency of goiter, random sampling was applied to select 884 children to determine UIC. To establish the excretion of inorganic iodine in a single portion of urine in the field, express diagnostics, the "Iodine test" kits (manufactured in Ukraine), was applied. Read More

    InDel in Phospholipase-C-B-1 is linked with euthyroid multinodular goitre.
    Thyroid 2018 Jun 13. Epub 2018 Jun 13.
    Cardiff University, School of Medicine , Centre for Endocrine & Diabetes Sciences , Heath Park , Cardiff, United Kingdom of Great Britain and Northern Ireland , CF14 4XN.
    Euthyroid multinodular goiter (MNG) is common but little is known about the genetic variation conferring predisposition. Previously we reported a family with MNG of adolescent onset in which some family members developed papillary thyroid carcinomas (PTC). We conducted a genome-wide linkage analysis and next generation sequencing to identify genetic variants that may confer disease predisposition. Read More

    The Role of Different Molecular Markers in Papillary Thyroid Cancer Patients with Acromegaly.
    Exp Clin Endocrinol Diabetes 2018 Jun 11. Epub 2018 Jun 11.
    Division of Endocrinology-Metabolism and Diabetes, Department of Internal Medicine, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey.
    Purpose: Prevalence of papillary thyroid cancer (PTC) is increased in patients with acromegaly. We aimed to determine the protein expression of BRAF, RAS, RET, insulin like growth factor 1(IGF1), Galectine 3, CD56 in patients with PTC related acromegaly and to compare the extensity of these expressions with normal PTC patients and benign thyroid nodules.

    Methods: We studied 313 patients with acromegaly followed in Cerrahpasa Medical Faculty, Endocrinology and Metabolism Clinic between 1998 and 2015. Read More

    Association of FoxP3 promoter polymorphisms with the risk of Graves' disease in ethnic Kashmiri population.
    Gene 2018 Jun 8. Epub 2018 Jun 8.
    Department of Endocrinology, Sher-i-Kashmir Institute of Medical Sciences, Srinagar, Jammu & Kashmir, India. Electronic address:
    Graves' disease is a multifactorial autoimmune disorder of the thyroid gland, with some extra-thyroidal complications like eye and skin abnormalities in some patients. GD is more prevalent in women than men and is the leading cause of hyperthyroidism worldwide. A complex interaction between genetic and environmental factors is the proposed cause which triggers immune system to produce autoantibodies stimulating the TSH receptor, leading to clinical manifestations such as hyperthyroidism, diffuse thyroid enlargement (goiter) and often ophthalmopathy in affected individuals. Read More

    Nontoxic Multinodular Goitre and Incidental Thyroid Cancer: What Is the Best Surgical Strategy?-A Retrospective Study of 2032 Patients.
    Int J Endocrinol 2018 14;2018:4735436. Epub 2018 May 14.
    First Department and Clinic of General, Gastroenterological and Endocrine Surgery, Wroclaw Medical University, Maria Sklodowska-Curie Street 66, 50-369 Wroclaw, Poland.
    Objectives: A discussion with regard to the most optimal surgical procedure in nontoxic multinodular goitre (NTMNG). We assessed and compared three main types of operations in 2032 patients with NTMNG.

    Methods: This is a retrospective study of 2032 patients operated on in one center due to NTMNG. Read More

    [Syncope due to giant goitre].
    Ugeskr Laeger 2018 Jun;180(24)
    We present a case report of a 70-year-old male patient with a giant goitre. The patient experienced recurrent episodes of syncope/fainting, when he turned his head towards to the right, and he experienced discomfort when lying on his back. A CT scan showed compression of the right carotid artery and carotid sinus from a thyroid mass. Read More

    New Perspectives Regarding Anaplastic Thyroid Carcinoma Approach Improvement.
    Endocr Metab Immune Disord Drug Targets 2018 Jun 10. Epub 2018 Jun 10.
    Department of General Surgery, Centro Hospitalar Sao Joao. Portugal.
    Background And Objective: Anaplastic thyroid carcinoma is rare, but represents the deadliest type of thyroid cancer that is characterised by a rapid course. Diagnosis is usually made at a late stage, when more than half of the patients have distant metastasis. Our main purpose is to review the current information on anaplastic thyroid aetiology and risk factors that might contribute to an earlier diagnosis as well as to give new perspectives regarding the most recent treatment options and future directions. Read More

    Management of thyroid cytological material, pre-analytical procedures and bio-banking.
    Cytopathology 2018 Jun 9. Epub 2018 Jun 9.
    Service of Clinical Pathology, Lausanne University Hospital, Institute of Pathology, Lausanne, Switzerland.
    Thyroid nodules are common and increasingly detected due to recent advances in imaging techniques. However, clinically relevant thyroid cancer is rare and the mortality from aggressive thyroid cancer remains constant. FNAC (Fine Needle Aspiration Cytology) is a standard method for diagnosing thyroid malignancy and the discrimination of malignant nodules from goiter. Read More

    Pattern of presentation of Graves' disease and response to radioiodine therapy in South African men.
    Pan Afr Med J 2018 18;29:48. Epub 2018 Jan 18.
    Division of Nuclear Medicine, Department of Medical Imaging & Clinical Oncology, Tygerberg Hospital, Western Cape Province, South Africa.
    Introduction: Typically hyperthyroidism has been more often associated with the female gender. There is a large female predilection (male:female sex ratio up to 1:10), with little documentation in the literature about wholly male hyperthyroid populations. A male incidence of 0. Read More

    A Case Report of Dilated Biventricular Heart Failure from Hyperthyroidism: A Rare Presentation.
    Cureus 2018 Apr 2;10(4):e2410. Epub 2018 Apr 2.
    Cardiology, Rapides Regional Hospital, Alexandria, La.
    Hyperthyroidism is a common metabolic disorder with many cardiovascular manifestations. In rare cases, untreated hyperthyroidism can lead to thyrotoxic cardiomyopathy with severe left ventricular (LV) dysfunction. This case report aims to discuss the pathogenesis of heart failure in hyperthyroidism and the available treatment options. Read More

    Incidental thyroid carcinoma in surgery-treated hyperthyroid patients with Graves' disease: a systematic review and meta-analysis of cohort studies.
    Cancer Manag Res 2018 21;10:1201-1207. Epub 2018 May 21.
    Department of Endocrinology and Metabolism, West China Hospital, Sichuan University, Wuhou District, Chengdu, Sichuan, People's Republic of China.
    Background: The association between Graves' disease (GD) and thyroid carcinoma remains controversial. This study aimed to investigate incidental thyroid carcinoma (ITC) in surgery-treated hyperthyroid patients with and without GD.

    Materials And Methods: We searched PubMed and EMBASE for cohort studies investigating ITC in surgery-treated hyperthyroid patients without prediagnosed thyroid carcinoma in accordance with the Meta-Analysis of Observational Studies in Epidemiology guidelines. Read More

    Airway Management during Thyroidectomy for a Giant Goitre due to McCune-Albright Syndrome.
    Case Rep Anesthesiol 2018 6;2018:4219187. Epub 2018 May 6.
    Department of Emergency and Critical Care Medicine, Hyogo College of Medicine, Hyōgo Prefecture, Japan.
    There have been no case reports to date describing the technical aspects of tracheal intubation in a patient with a goitre associated with McCune-Albright syndrome (MAS), even though goitre is frequently observed in this condition. I describe a case of resection of a giant goitre in a patient with MAS, with difficult airway management. Preoperative investigation showed that the trachea was shifted to the right by the goitre, with the narrowest part of the tracheal lumen 4 mm in diameter. Read More

    Thyrotoxicosis after iodine fortification. A 21 year Danish population based study.
    Clin Endocrinol (Oxf) 2018 May 31. Epub 2018 May 31.
    Department of Endocrinology, Aalborg University Hospital, Aalborg, Denmark.
    Objective: Monitoring the influence of cautious iodine fortification (IF) on the incidence rate of overt thyrotoxicosis in Denmark with formerly frequent multinodular toxic goitre.

    Design: A 21 year (1997-2017) prospective population-based study identified all new cases of overt biochemical thyrotoxicosis in two open cohorts: a Western cohort with moderate iodine deficiency (ID) and an Eastern cohort with mild ID (total n=533,969 by January 1 , 1997). A diagnostic algorithm was applied to all thyroid function tests performed within the study areas. Read More

    American Thyroid Association Statement on Postoperative Hypoparathyroidism: Diagnosis, Prevention, and Management in Adults.
    Thyroid 2018 May 31. Epub 2018 May 31.
    UCLA, Head & neck surgery, Los Angeles, California, United States ;
    Background: Hypoparathyroidism (hypoPT) is the most common complication after bilateral thyroid operations. Thyroid surgeons must employ strategies for minimizing and preventing post-thyroidectomy hypoPT. The objective of this American Thyroid Association Surgical Affairs Committee Statement is to provide an overview of its diagnosis, prevention and treatment. Read More

    Remarkable Presentation: Anaplastic Thyroid Carcinoma Arising from Chronic Hyperthyroidism.
    Case Rep Endocrinol 2018 1;2018:7261264. Epub 2018 Apr 1.
    Section of Endocrinology, Department of Internal Medicine, West Virginia University School of Medicine, Morgantown, WV, USA.
    Background: Undifferentiated anaplastic carcinoma rarely develops from chronic hyperthyroidism. Although acute hyperthyroidism can develop prior to anaplastic transformation, chronic hyperthyroidism was thought to be a protective measure against thyroid malignancy.

    Methods: A 79-year-old female presented acutely to the hospital with dyspnea. Read More

    Clinicopathological profile of papillary carcinoma of thyroid: A 10-year experience in a tertiary care institute in North Karnataka, India.
    Indian J Cancer 2017 Jul-Sep;54(3):514-518
    Department of Pathology, Karnataka Institute of Medical Sciences, Hubli, Karnataka, India.
    Context: Papillary thyroid carcinoma (PTC) is the most common thyroid malignancy accounting for 80% of the thyroid cancers. Many histopathologic variants of PTC have been recognized, and few of these are of prognostic significance. The studies on clinicopathological features of PTC and its variants are so far seldom reported in India. Read More

    [Risk factors of central neck lymph node metastasis in cN0 papillary thyroid carcinoma].
    Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2017 Aug;31(15):1141-1145
    Department of Otolaryngology Head and Neck Surgery, Beijing Friendship Hospital, Capital Medical Universtity, Beijing, 100050, China.
    To investigate the risk factors of central neck lymph node metastasis (CNLNM) in cN0 papillary thyroid carcinoma. Retrospective analysis of 114 patients with papillary thyroid carcinoma in stage of cN0 who underwent primary treatment. Collected the clinical and pathological data, used the univariate and multivariate analysis to investigate the risk factors of central neck lymph node metastasis and high volume central neck lymph node metastasis. Read More

    [An immunohistochemical study of CTHRC1,Vimentin,E-cadherin expression in papillary thyroid carcinoma].
    Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Apr;32(8):595-598
    Department of Otolaryngology, Peking University International Hospital, Beijing, 102206, China.
    To investigate the expression and significance of CTHRC1 in patients with papillary thyroid cancinoma.We collected 63 specimens of papillary thyroid carcinoma tissue with 36 specimens of the adjacent normal thyroid tissue and 23 specimens of thyroid nodular goiter. The expressions of CTHRC1 protein in these tissues were detected by immunohistochemical staining. Read More

    Ectopic Intratracheal Thyroid: A Rare Cause of Airway Obstruction.
    Case Rep Otolaryngol 2018 27;2018:2897943. Epub 2018 Jan 27.
    Department of Otolaryngology, Head and Neck Surgery, Hamad Medical Corporation, Doha, Qatar.
    Ectopic intratracheal thyroid tissue (EITT) is a rare abnormality with only limited cases reported so far. The presenting symptoms can be very similar to those of bronchial asthma. We discuss the case of a 29-year-old man with subglottic ectopic thyroid, with a history of thyroid surgery for goiter, which has been managed with laser-assisted endoscopic approach. Read More

    Iodine-Induced Fetal Hypothyroidism: Diagnosis and Treatment with Intra-Amniotic Levothyroxine.
    Horm Res Paediatr 2018 May 23:1-5. Epub 2018 May 23.
    Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
    Background: Iodine is necessary for fetal thyroid development. Excess maternal intake of iodine can cause fetal hypothyroidism due to the inability to escape from the Wolff-Chaikoff effect in utero.

    Case Report: We report a case of fetal hypothyroid goiter secondary to inadvertent excess maternal iodine ingestion from infertility supplements. Read More

    High expression of CD10 in anaplastic thyroid carcinomas.
    Histopathology 2018 May 23. Epub 2018 May 23.
    Department of Pathology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Yamanashi, Japan.
    Aims: CD10 is an endopeptidase that degrades variable bioactive peptides in extra-cellular matrix. In addition to the enzymatic degradation, it affects multiple intra-cellular signal transduction pathways. CD10 expression has been extensively studied in human epithelial cancers of numerous organs and sites. Read More

    Hashimoto's thyroiditis, nodular goiter or follicular adenoma combined with papillary thyroid carcinoma play protective role in patients.
    Neoplasma 2018 Mar;65(3):436-440
    Department of Pathology, Affiliated Hospital of Jining Medical University, Jining, China.
    Papillary thyroid carcinoma (PTC) is often combined with other types of thyroid disease, such as Hashimoto's thyroiditis(HT), nodular goiter(NG), Follicular adenoma(FA) and other types. However, the function of these diseases in PTC tumorigenesis and development is not well understood. In this research, 563 PTC patients were recruited and divided into two groups according to pathological diagnosis, namely simple PTC (PTC) and PTC combined with other thyroid diseases (PTC+). Read More

    Hygienic assessment of the effects of pesticides application on adult population morbidity with thyroid gland diseases.
    Wiad Lek 2018 ;71(2 pt 2):353-357
    Hygiene And Ecology Institute, Bogomolets National Medical University, Kyiv, Ukraine.
    Objective: Introduction: It is proved that some groups of fungicides and herbicides are capable of affecting the thyroid gland, provoking its growth, leading to a compensatory change in the activity of the hormones synthesis. Therefore, the presence of their residual amounts in plant may affect the level of thyroid gland pathology. The aim of the work was to analyze the influence of pesticide application on the Ukrainian adult population morbidity with thyroid diseases in the period from 2001 to 2014. Read More

    Acute Suppurative Thyroiditis in an Intravenous Drug User with a Preexisting Goiter.
    Case Rep Med 2018 26;2018:5098712. Epub 2018 Mar 26.
    Department of Medicine, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ 08901, USA.
    Acute suppurative thyroiditis (AST) is an uncommon, potentially life-threatening cause of a rapidly enlarging neck mass. It may present similarly to subacute thyroiditis, a relatively benign and self-limiting condition. We report a case of AST in an adult intravenous (IV) drug user with a preexisting goiter who presented with a left forearm abscess that grew methicillin-sensitive . Read More

    Congenital dyshormonogenic hypothyroidism with goiter caused by a sodium/iodide symporter (SLC5A5) mutation in a family of Shih-Tzu dogs.
    Domest Anim Endocrinol 2018 Apr 24;65:1-8. Epub 2018 Apr 24.
    Laboratory of Comparative Medical Genetics and Department of Microbiology and Molecular Genetics, College of Veterinary Medicine, Michigan State University, East Lansing, MI, USA.
    An iodide transport defect (ITD) in the thyroid gland was determined to cause congenital dyshormonogenic hypothyroidism with goiter (CDHG) in 2 members of a family of Shih-Tzu dogs. Strikingly, both dogs were also diagnosed with dilated cardiomyopathy at 24 and 1.5 mo of age. Read More

    Heritage of Stanislaw Ciechanowski (1869-1945)-Discoverer of pathogenesis of prostatic hyperplasia-passionis insignia signis fulgent mirificis .
    Prostate 2018 May 18. Epub 2018 May 18.
    Department of General Pathomorphology, Medical University of Bialystok, Bialystok, Poland.
    Background: Prostatic enlargement was first correctly recognized as a prostatic hyperplasia by professor of anatomic pathology, Stanisław Ciechanowski (1869-1945) in Cracow on contrary to Parisian urologist Jean Casimir Félix Guyon's concepts of progressing atherosclerosis as a morphological cause of prostatic overgrowth and mechanical insufficiency of lower urinary tract.

    Methods: Primary resources were analyzed about Stanisław Ciechanowski mainly from depositories of the Section of Special Collection, Stanisław Konopka Main Medical Library Warsaw and Polish bibliograhy of Estreichers at Jagiellonian University.

    Results: Professor of anatomic pathology, Stanisław Ciechanowski (1869-1945) was the first to state that chronic inflammation induced overgrowth of parenchymatous and stromal prostate components in course of benign prostatic hyperplasia. Read More

    Motor Interconnections Between Superior and Inferior Laryngeal Nerves.
    Cureus 2018 Mar 16;10(3):e2337. Epub 2018 Mar 16.
    Department of Surgery, Duzce University Medical Faculty.
    Introduction Anatomical studies on human cadavers have established anastomoses between laryngeal nerves. However, we need to functionally identify motor communication via these anastomoses between the recurrent laryngeal nerve (RLN) and the external branch of the superior laryngeal nerve (EBSLN) in living bodies. We aim to establish motor interconnections using intraoperative nerve monitoring (IONM). Read More

    [Prediction of activity and severity of endocrine ophthalmopathy by multidimensional linear regression modeling].
    Vestn Oftalmol 2018 ;134(2):23-31
    State Research Center of Preventive Medicine, Ministry of Health of the Russian Federation, 10 building 3 Petroverigsky per., Moscow, Russian Federation, 101990.
    Endocrine ophthalmopathy (EOP) is a severe chronic autoimmune disease associated with autoimmune thyroid pathology that leads to loss of sight, cosmetic defects and quality of life decrease. EOP is difficult to give prognosis for due to various factors affecting its course and outcome.

    Purpose: To develop a reliable and precise prognosis method for EOP activity and severity based on personalized combination of risk factors in specific patients by multidimensional linear regression modeling. Read More

    Risk factors associated with intrathyroid extension of thyroid microcarcinomas.
    Langenbecks Arch Surg 2018 May 17. Epub 2018 May 17.
    Centre for Endocrine Surgery, Clinical Centre of Serbia, Koste Todorovica 8, Belgrade, 11000, Serbia.
    Purpose: The aims of this study were to investigate the rate of intrathyroid extension of papillary thyroid microcarcinoma (PTMC) in patients operated for benign thyroid disease and to identify independent risk factors associated with it.

    Methods: A retrospective study of 301 patients operated for benign thyroid diseases (hyperthyroid diseases, multinodular goitre, Hashimoto thyroiditis and benign thyroid tumours) was performed at a high-volume endocrine surgery unit of a tertiary referral academic hospital, in a 5-year period. These patients had a PTMC incidentally discovered on definite histopathological findings following total or near-total thyroidectomy. Read More

    Urinary iodine concentration and thyroid volume of pregnant women attending antenatal care in two selected hospitals in Ashanti Region, Ghana: a comparative cross-sectional study.
    BMC Pregnancy Childbirth 2018 May 15;18(1):166. Epub 2018 May 15.
    Department of Sonography, Faculty of Allied Health Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.
    Background: Iodine deficiency is a major public health problem affecting people worldwide, particularly pregnant women. Iodine requirements increase substantially during pregnancy making pregnant women vulnerable to iodine deficiency and its disorders such as abortions, stillbirths and pregnancy goitre as well as congenital abnormalities, cretinism and mental retardation in their children. The primary aim of this study was to evaluate the prevalence of iodine deficiency and goitre among pregnant women attending antenatal sessions at two selected hospitals in Ashanti region, Ghana. Read More

    A Novel Missense Mutation in SLC5A5 Gene in a Sudanese Family with Congenital Hypothyroidism.
    Thyroid 2018 Jun 5. Epub 2018 Jun 5.
    1 Department of Medicine, University of Miami Miller School of Medicine , Miami, Florida.
    Thyroid hormone synthesis requires the presence of iodide. The sodium-iodide symporter (NIS) is a glycoprotein that mediates the active uptake of iodide from the blood stream into the thyroid grand. NIS defects due to SLC5A5 gene mutations are known to cause congenital hypothyroidism (CH). Read More

    [Giant Intrathoracic Goiter Requiring Emergency Airway Management;Report of a Case].
    Kyobu Geka 2018 May;71(5):392-395
    Department of Thoracic Surgery, Yamagata Prefectural Central Hospital, Yamagata, Japan.
    An 81-year-old woman with acute respiratory distress was referred to our hospital. Computed tomography showed a large mass in the upper mediastinum with severe tracheal stenosis. Endotracheal intubation was performed under the preparation of extracorporeal membrane oxygenation and high-frequency jet ventilation, and the tumor was completely removed. Read More

    Mutation analysis of SLC26A4 (Pendrin) gene in a Brazilian sample of hearing-impaired subjects.
    BMC Med Genet 2018 May 8;19(1):73. Epub 2018 May 8.
    Centro de Pesquisas sobre o Genoma Humano e Células-Tronco, Departamento de Genética e Biologia Evolutiva, Instituto de Biociências, Universidade de São Paulo, São Paulo, Brazil.
    Background: Mutations in the SLC26A4 gene are associated with Pendred syndrome and autosomal recessive non-syndromic deafness (DFNB4). Both disorders have similar audiologic characteristics: bilateral hearing loss, often severe or profound, which may be associated with abnormalities of the inner ear, such as dilatation of the vestibular aqueduct or Mondini dysplasia. But, in Pendred syndrome (OMIM #274600), with autosomal recessive inheritance, besides congenital sensorineural deafness, goiter or thyroid dysfunctions are frequently present. Read More

    Evaluation and Management of the Child with Hypothyroidism.
    Recent Pat Endocr Metab Immune Drug Discov 2018 05 8. Epub 2018 May 8.
    Departments of Medicine, Community Health Sciences, and Oncology, The University of Calgary, Calgary, Alberta. Canada.
    Background: Thyroid hormones are critical for early neurocognitive development as well as growth and development throughout childhood. Prompt recognition and treatment of hypothyroidism is therefore of utmost importance to optimize physical and neurodevelopmental outcomes.

    Objective: To review in depth the evaluation, diagnosis, and treatment of hypothyroidism in children. Read More

    Hypothyroidism in patients with autoimmune pancreatitis.
    World J Gastrointest Pharmacol Ther 2018 May;9(2):16-21
    Department of Internal Medicine, Tokyo Metropolitan Komagome Hospital, Tokyo 113-8677, Japan.
    Aim: To examine thyroid function and clinical features of hypothyroidism in autoimmune pancreatitis (AIP) patients.

    Methods: We examined thyroid function in 77 patients with type 1 AIP (50 males, 27 females; median age 68 years, range 33-85) diagnosed according to the Japanese diagnostic criteria for AIP 2011. We compared clinical and serological findings between patients with and without various categories of hypothyroidism. Read More

    Voice quality preservation in thyroid surgery with neuromonitoring.
    Endocrine 2018 May 5. Epub 2018 May 5.
    Department of Endocrine Surgery, Third Chair of General Surgery, Jagiellonian University Medical College, Kraków, Poland.
    Purpose: Voice problems are common after thyroidectomy. The aim of this study was to assess the voice related quality of life after thyroidectomy with neuromonitoring. The sociodemographic and treatment factors influencing the quality of voice after the operation were investigated. Read More

    Recognizing pinhole parallax error for accurate localization of thyroid and parathyroid pathology.
    J Nucl Med Technol 2018 May 3. Epub 2018 May 3.
    Mubarak Al-Kabeer Hospital.
    Parallax error is a pitfall of pinhole scintigraphy which causes mislocalization of the objects. It is important to notice this error on pinhole thyroid and parathyroid scintigraphy and obtain additional images with parallel-hole collimator to accurately determine the upper and lower margins of large goiter and nodules and location of the ectopic thyroid tissue and parathyroid adenomas. In this teaching case report we wanted to revisit pinhole parallax error, present pinhole and SPECT/CT images of a case with large hyperactive thyroid nodule and review the literature and potential solutions to this important problem. Read More

    Adverse effects on thyroid of Chinese children exposed to long-term iodine excess: optimal and safe Tolerable Upper Intake Levels of iodine for 7- to 14-y-old children.
    Am J Clin Nutr 2018 May;107(5):780-788
    Department of Nutrition and Food Hygiene, School of Public Health, Tianjin Medical University, Tianjin, China.
    Background: The adverse effects of iodine excess on the thyroid in children are not well understood, and the Tolerable Upper Intake Level for iodine in children is unclear.

    Objective: The aims of this study were to assess the effects of chronic long-term iodine excess on thyroid function in children and to explore the safe Tolerable Upper Intake Level of iodine in Chinese children.

    Design: A multistage cross-sectional study was conducted in 2224 children from areas with adequate to excessive iodine content in drinking water. Read More

    Surgical approach to the intrathoracic goiter.
    Laryngoscope Investig Otolaryngol 2018 Apr 25;3(2):127-132. Epub 2018 Mar 25.
    Department of Thoracic Surgery Assaf HaRofeh Medical Center, affiliated to the Sackler Faculty of Medicine, Tel Aviv University Israel.
    Objective: In a retrospective study, the authors analyzed the surgical approach to the intrathoracic goiter to avoid sternotomy or thoracotomy.

    Methods: We selected 70 intrathoracic cases of multinodular goiter out of 988 cases of thyroidectomy and compared them with cervical goiter cases. Surgical technique, results, and postsurgical complications were assessed. Read More

    A novel mutation in the TG gene (G2322S) causing congenital hypothyroidism in a Sudanese family: a case report.
    BMC Med Genet 2018 May 2;19(1):69. Epub 2018 May 2.
    Department of Medicine, University of Miami Miller School of Medicine, 1120 NW 14th St., Room 310F, Miami, FL, 33136, USA.
    Background: Congenital hypothyroidism (CH) has an incidence of approximately 1:3000, but only 15% have mutations in the thyroid hormone synthesis pathways. Genetic analysis allows for the precise diagnosis.

    Case Presentation: A 3-week old girl presented with a large goiter, serum TSH > 100 mIU/L (reference range: 0. Read More

    30-Day Morbidity and Mortality Rates in Elderly Subjects Following Surgical Tracheostomy.
    Respir Care 2018 May 1. Epub 2018 May 1.
    Department of Otolaryngology-Head and Neck Surgery, Assuta Ashdod University Hospital, Ben Gurion University Faculty of Health Sciences, Ashdod, Israel.
    Background: Tracheostomy is considered to be effective in the respiratory support of mechanically ventilated patients. We studied a single-center experience of surgical tracheostomy in mechanically ventilated patients to describe the demographics, risk factors, and outcomes of early (≤ 14 d after ventilation) versus late surgical tracheostomy (≥ 15 d after ventilation).

    Methods: In this retrospective study, we collected demographic data, medical history, timing of surgical tracheostomy in relation to ventilation day, blood test results, preoperative surgical assessment (subjective impression of neck length, difficulty in neck extension, presence of a goiter), intraoperative complications (bleeding > 100 mL, difficulties in cannula insertion), and postoperative morbidities (bleeding, wound infection, fever, inadvertent de-cannulation, and 30-d postoperative mortality rate) of subjects who underwent surgical tracheostomy in a secondary medical center during 2010-2015. Read More

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