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    DICER1 mutations are frequent in adolescent-onset papillary thyroid carcinoma.
    J Clin Endocrinol Metab 2018 Feb 21. Epub 2018 Feb 21.
    Lady Davis Institute, Segal Cancer Centre, Jewish General Hospital, Montreal, Quebec, Canada.
    Context: Papillary thyroid carcinoma (PTC) is a common malignancy in adolescence and is molecularly and clinically distinct from adult PTC. Mutations in the DICER1 gene are associated with thyroid abnormalities including multinodular goitre and differentiated thyroid carcinoma.

    Objective: In this study, we sought to characterize the prevalence of DICER1 variants in paediatric PTC, specifically in tumours without conventional PTC oncogenic alterations. Read More

    Mutiple DICER1-related lesions associated with a germline deep intronic mutation.
    Pediatr Blood Cancer 2018 Feb 22. Epub 2018 Feb 22.
    Service de Génétique, Institut Curie, Paris, France.
    Germline DICER1 pathogenic variants predispose to numerous benign and malignant tumors. In this report, we describe DICER1 gene analysis in an adolescent diagnosed with multinodular goiter, ovarian Sertoli-Leydig cell tumor, and lung cyst. DICER1 mutational screening at the DNA level failed to detect any pathogenic variant. Read More

    In iodine-induced thyrotoxicosis, steroid therapy today could keep the surgical knife at bay.
    J Pediatr Endocrinol Metab 2018 Feb 21. Epub 2018 Feb 21.
    Division of Endocrinology, Department of Pediatrics, Nationwide Children's Hospital/The Ohio State University College of Medicine, Columbus, OH, USA.
    Background: Amiodarone-induced thyrotoxicosis (AIT) type 2, characterized as a destructive thyroiditis, is well described in the medical literature; however, iodine-induced thyrotoxicosis (IIT) is not, though the latter has similar features and can be managed similarly.

    Case Presentation: We present a 17-year-old female who presented with a history of an intermittent goiter with thyroid function tests (TFTs): thyroid-stimulating hormone (TSH)<0.015 (0. Read More

    Type 1 diabetes mellitus and Graves' disease in Down's syndrome--a rare combination.
    Afr J Med Med Sci 2016 Sep;45(3):299-301
    Background: Autoimmune diseases including thyroid. disorders, type 1 diabetes and celiac disease are commoner in persons with Down's syndrome compared with the general population. Coexistent type 1 diabetes and hyperthyroidism in Down's syndrome is however not commonly reported in literature. Read More

    Surgical management of the recurrent laryngeal nerve in thyroidectomy: American Head and Neck Society Consensus Statement.
    Head Neck 2018 Feb 20. Epub 2018 Feb 20.
    Division of Thyroid and Parathyroid Surgery, Department of Otolaryngology Massachusetts Eye and Ear Infirmary, Boston, Massachusetts.
    "I have noticed in operations of this kind, which I have seen performed by others upon the living, and in a number of excisions, which I have myself performed on the dead body, that most of the difficulty in the separation of the tumor has occurred in the region of these ligaments…. This difficulty, I believe, to be a very frequent source of that accident, which so commonly occurs in removal of goiter, I mean division of the recurrent laryngeal nerve." Sir James Berry (1887). Read More

    Concurrent variant type 3 autoimmune polyglandular syndrome and pulmonary arterial hypertension in a Japanese woman.
    Endocr J 2018 Feb 16. Epub 2018 Feb 16.
    Department of Endocrinology and Metabolism, Dokkyo Medical University, Mibu, Shimotsuga, Tochigi, Japan.
    We describe a very rare case of concurrent variant type 3 autoimmune polyglandular syndrome (APS) and pulmonary arterial hypertension (PAH). A previously healthy 65-year-old Japanese woman was referred to our university hospital with a 2-month history of general fatigue and hyperglycemia. Laboratory tests revealed severe hyperglycemia (plasma glucose 543 mg/dL and HbA1c 10. Read More

    [Thyroid carcinoma on struma ovarii: Diagnosis and treatment].
    Bull Cancer 2018 Feb 16. Epub 2018 Feb 16.
    Institut Bergonié, département de médecine nucléaire et de cancérologie thyroidienne, 229, cours de l'Argonne, 33076 Bordeaux, France.
    Thyroid carcinoma on struma ovarii (TCSO) is a rare ovarian tumour, derivate from monodermic teratomas. It represents about 0.01% of overall ovarian tumours and 5 to 10% of struma ovarii. Read More

    Critical airway compression caused by a large mediastinal tumour with spontaneous haemorrhage.
    Respirol Case Rep 2018 Apr 15;6(3):e00300. Epub 2018 Feb 15.
    Division of Thoracic Surgery, Department of SurgeryTaipei Veterans General HospitalTaipeiTaiwan.
    We report the case of a 77-year-old woman presenting with out-of-hospital cardiac arrest, which was then interpreted as an acute, life-threatening critical airway compression by a huge mediastinal tumour without appropriate diagnosis. Emergency extracorporeal membrane oxygenation was cannulated for sufficient respiratory support after spontaneous circulation was regained. After the multidisciplinary team, involving thoracic surgeons, discussed the resectability of the mediastinal tumour, the patient underwent successful resection of the mediastinal tumour through a median sternotomy. Read More

    The effect of Metformin treatment in obese insulin-resistant patients with euthyroid goiter.
    Acta Clin Belg 2018 Feb 16:1-7. Epub 2018 Feb 16.
    a Department of Endocrinology , Iuliu Haţieganu University of Medicine and Pharmacy , Cluj-Napoca , Romania.
    Objective The study's objective was to evaluate the thyroid parameters in obese insulin-resistant patients with euthyroid diffuse or nodular goiter, following Metformin treatment. Patients and methods The study was experimental, open, and prospective. Fifty-three patients aged 18-68 were enrolled for two years. Read More

    Body weight change is unpredictable after total thyroidectomy.
    ANZ J Surg 2018 Feb 14. Epub 2018 Feb 14.
    Monash University Endocrine Surgery Unit, The Alfred Hospital, Melbourne, Victoria, Australia.
    Background: There is a common perception that total thyroidectomy causes weight gain beyond expected age-related changes, even when thyroid replacement therapy induces a euthyroid state. The aim of this study was to determine whether patients who underwent total thyroidectomy for a wide spectrum of conditions experienced weight gain following surgery.

    Methods: We retrospectively studied 107 consecutive total thyroidectomy patients treated between January 2013 and June 2014. Read More

    Thyroid hemiagenesis associated with multinodular goiter and Hashimoto's thyroiditis.
    G Chir 2017 Nov-Dec;38(6):291-294
    Thyroid hemiagenesis is a rare congenital abnormality in which one of the thyroid lobes is not developed. It can be associated with various thyroid diseases, such as Grave's disease, nodular goiter and thyroid neoplasm, rarely with hyperparathyroidism. We report a case of a 50-year old woman with left thyroid lobe agenesis diagnosed by ultrasonography and scintigraphy. Read More

    Alteration in the serum concentrations of FGF19, FGFR4 and βKlotho in patients with thyroid cancer.
    Cytokine 2018 Feb 10;105:32-36. Epub 2018 Feb 10.
    Department of Immunoendocrinology, Chair of Endocrinology, Medical University of Lodz, Sterlinga 3, 91-425 Lodz, Poland.
    Introduction: βKlotho (βKL) is known to act as co-receptor for fibroblast growth factor receptor 4 (FGFR4) which is the main cognate receptor for fibroblast growth factor 19 (FGF19). Dysregulation of this FGF19/FGFR4/βKL signaling axis has been implicated in the pathogenesis of several cancers. However, its role in the pathogenesis of thyroid cancer has not been determined. Read More

    Diagnostic accuracy of a new fluoroenzyme immunoassay for the detection of TSH receptor autoantibodies in Graves' disease.
    Auto Immun Highlights 2018 Feb 12;9(1). Epub 2018 Feb 12.
    Clinical Pathology Laboratory, S. Maria degli Angeli Hospital, Pordenone, Italy.
    Purpose: Thyrotropin receptor (TSHR) autoantibodies (TRAbs) are a hallmark of Graves' disease (GD). The aim of this study was to evaluate the diagnostic accuracy of a new third generation automatic fluorescence enzyme immunoassay for TRAb measurement in GD, in comparison with two current IMAs.

    Methods: Sera of 439 subjects (57 patients with untreated GD, 34 with treated GD, 15 with GD and Graves' orbitopathy, 52 with multinodular non-toxic goiter, 86 with Hashimoto's thyroiditis, 20 with toxic adenoma or toxic multinodular goiter, 55 with non-thyroid autoimmune diseases and 120 normal controls) were tested for TRAbs with the ELiAanti-TSH-R assay (ThermoFischer Scientific, Uppsala, Sweden), the TRAKRIA, Brahms (Thermo Scientific, Hennigsdorf, Germany) and the ImmuliteTSI assay (Siemens Healthcare, Llanberis, UK). Read More

    Mantle Cell Lymphoma in the Thyroid: A Rare Presentation.
    Case Rep Pathol 2017 25;2017:6749801. Epub 2017 Dec 25.
    Division of Endocrinology, University of Massachusetts Medical School, 55 Lake Avenue N., Worcester, MA 01655, USA.
    Background: While 2% of all extranodal Non-Hodgkin Lymphomas present in the thyroid, there exists insufficient data to describe the incidence of mantle cell lymphoma in the thyroid. A case series of 1400 patients revealed that <1% of thyroid lymphomas may be MCL; hence better understanding of the disease course is essential.

    Patient Findings: A 65-year-old female was referred for a multinodular goiter. Read More

    An association of myasthenia gravis with Hashimoto's thyroiditis in a patient with a multinodular goitre.
    Malays Fam Physician 2017 31;12(2):29-31. Epub 2017 Aug 31.
    MD (USM), MMed (Family Medicine ) (USM), Universiti Sains Malaysia, Kelantan, Malaysia Email:
    Introduction: The association of myasthenia gravis (MG) with other autoimmune diseases including autoimmune thyroid disease (ATD) is well recognised, although rare. The occurrence of both diseases can occur in two ways: either disease preceding the other, or concurrently. The presentation of MG in association with ATD can range from ocular to generalised disease. Read More

    Epidemiology and Clinical Features of Thyroid-associated Orbitopathy in Accra.
    Middle East Afr J Ophthalmol 2017 Oct-Dec;24(4):183-189
    Department of Surgery, Eye Unit, School of Medicine and Dentistry, University of Ghana, Accra, Ghana.
    Purpose: Thyroid-associated orbitopathy (TAO), a clinical manifestation of Graves' disease, is an autoimmune disorder of the orbital and periorbital tissue. Data on the epidemiology and clinical presentation of TAO in Africa are generally scarce and unavailable in Ghana. We investigated the epidemiology and clinical features of TAO among patients with thyroid disorders attending the Korle Bu Teaching Hospital, Accra. Read More

    Thyroid disorders in obese patients. Does insulin resistance make a difference?
    Arch Endocrinol Metab 2017 Dec;61(6):575-583
    Department of Endocrinology, Iuliu Haţieganu University of Medicine and Pharmacy Cluj-Napoca, Romania.
    Objective: The aim of this study was to evaluate the association between insulin resistance and thyroid pathology in obese patients, and compare the results between insulin-resistant and noninsulin-resistant patients.

    Subjects And Methods: Obese/nondiabetic patients, aged 18-70 years, attending the outpatient endocrinology service for 2 years were consecutively included. We evaluated the patients' fasting plasma glucose, insulin, homeostasis model assessment of insulin resistance index (HOMA-IR), thyroid-stimulating hormone (TSH), free thyroxine (FT4), antithyroperoxidase antibodies (TPO-Ab), antithyroglobulin antibodies (Tg-Ab), and thyroid ultrasound. Read More

    It is no longer the time to disregard thyroid metastases from breast cancer: a case report and review of the literature.
    BMC Cancer 2018 02 6;18(1):146. Epub 2018 Feb 6.
    Department of Clinical Medicine and Surgery, University of Naples "Federico II", via Sergio Pansini, 80131, Naples, Italy.
    Background: Metastases to the thyroid gland are more frequent than previously thought, although most of them are occult or not clinically relevant. Overall, only 42 cases of metastases to thyroid from breast cancer have been reported thus far. Here we report the case of a patient with breast cancer metastatic to the thyroid. Read More

    A single session of laser ablation for toxic thyroid nodules: three-year follow-up results.
    Int J Hyperthermia 2018 Feb 22:1-5. Epub 2018 Feb 22.
    b Studio Tiroide Prof. De Feo , Perugia , Italy.
    Purpose: To confirm the effectiveness of laser ablation on toxic nodules in a large population with three years of follow-up.

    Material And Methods: Between 2009 and 2014, we treated 82 patients with hyperthyroidism related to the presence of a toxic nodular goitre. Patients were pre-treated pharmacologically with methimazole prior to single session of laser ablation (LA) and then followed up every 3 months with FT4 and TSH blood tests as well as ultrasound examination of the nodules treated. Read More

    Effect of Goiter Dispersion Formula on Serum Cytokines in Hyperthyroidism Patients with Neurologic Manifestations of Graves' Disease: A Randomized Trial on 80 Cases.
    J Altern Complement Med 2018 Feb 6. Epub 2018 Feb 6.
    1 Department of Endocrinology, Traditional Chinese Medicine Hospital of Shanxi , Xi'an, China .
    Purpose: This study is aimed to explore the combined use of goiter dispersion formula and antithyroid drugs in the treatment of patients with neurologic manifestations of Graves' disease by examining its modulating effects on patients' cytokines.

    Methods: A total of 80 patients with Graves' disease were randomly divided into treatment and control groups. Patients of the treatment group received goiter dispersion formula and antithyroid drugs (methimazole or propylthiouracil), whereas those of the control group received antithyroid drug alone. Read More

    HMGA2 Gene Expression in Fine-needle Aspiration Samples of Thyroid Nodules as a Marker for Preoperative Diagnosis of Thyroid Cancer.
    Appl Immunohistochem Mol Morphol 2018 Feb 5. Epub 2018 Feb 5.
    Department of Oncology and Nuclear Medicine, Sestre Milosrdnice University Hospital Center, Zagreb, Croatia.
    There is a great interest in molecular markers that would help in the preoperative diagnosis of malignant thyroid nodules in cases of indeterminate fine-needle aspiration cytology. The aim of this study was to determine the diagnostic accuracy of HMGA2 gene expression in discriminating benign from malignant thyroid nodules. In this study, 237 preoperative thyroid fine-needle aspiration samples were analyzed prospectively for the expression of the HMGA2 gene by real-time reverse transcription polymerase chain reaction. Read More

    The Significance of 18F-Fluorocholine-PET/CT as Localizing Imaging Technique in Patients with Primary Hyperparathyroidism and Negative Conventional Imaging.
    Front Endocrinol (Lausanne) 2017 22;8:380. Epub 2018 Jan 22.
    Division of Endocrinology, Diabetes and Clinical Nutrition, Luzerner Kantonsspital, Luzern, Switzerland.
    Objective: The essential prerequisite for focused parathyroidectomy in patients with primary hyperparathyroidism (pHPT) is proper localization of all autonomic tissue. Sensitivity of conventional imaging modalities (ultrasound,Tc-sestamibi scintigraphy/SPECT/CT) is influenced by different factors (i.e. Read More

    Frequency of Thyroid-Stimulating Hormone Monitoring in Patients After Thyroidectomy: A Retrospective Study in Primary Care Practices in Germany.
    Exp Clin Endocrinol Diabetes 2018 Feb 2. Epub 2018 Feb 2.
    Faculty of Medicine, University of Paris 5, Paris, France.
    Aim: The goal of this study was to analyze the frequency of thyroid-stimulating hormone (TSH) monitoring in thyroidectomy patients followed by general practitioners in Germany.

    Methods: This study included all individuals ≥18 years who had undergone a thyroidectomy between 2000 and 2015 in 258 general practices in Germany. Another inclusion criterion was a minimum of three medical visits between 2015 and 2016, following thyroidectomy. Read More

    Associations between age and 50 trace element contents and relationships in intact thyroid of males.
    Aging Clin Exp Res 2018 Feb 2. Epub 2018 Feb 2.
    Laboratory of Dr. Gabriela CaraveoPiso, Feinberg School of Medicine, Northwestern University, 303 East Chicago Avenue, Ward 10-144, Chicago, IL, 60611-4296, USA.
    Background: It is unclear why a prevalence of thyroid dysfunction is higher in the elderly as compared to the younger population. An excess or deficiency of trace element contents in thyroid may play important role in goitre- and carcinogenesis of gland.

    Aim: To examine the variation with age of the mass fraction of 50 trace elements in intact (normal) male thyroid. Read More

    When Cardiopulmonary Bypass Is Not An Option-A Case of Massive Retrosternal Goiter With Severe Tracheal Compression in an Extremely Obese Patient.
    J Cardiothorac Vasc Anesth 2017 Jun 17. Epub 2017 Jun 17.
    Department of Anesthesia, Princess Alexandra Hospital, Brisbane, Australia; University of Queensland, School of Clinical Medicine, Princess Alexandra Hospital, Brisbane, Australia.

    ANCA positive relapsing polychondritis, Graves disease, and suspected moyamoya disease: A case report.
    Medicine (Baltimore) 2017 Dec;96(51):e9378
    Department of Rheumatology and Immunology, First Affiliated Hospital of Zhengzhou University, Zhengzhou City, Henan Province, P.R. China.
    Ratioinale: Relapsing polychondritis (RP) is a rare and heterogeneous disease complex of unknown origin which basically affects cartilaginous structures, 40% of which accompanied by rheumatic, hematologic, and endocrine disease. Among them, vasculitis is the most common accompanying type and usually presented with positive antineutrophilic cytoplasmic antibody (ANCA). The presence of ANCA could be primary or drug-induced like propylthiouracil (PTU). Read More

    Insulin autoimmune syndrome in a pregnant female: A rare case report.
    Medicine (Baltimore) 2017 Dec;96(51):e9213
    Department of Endocrinology and Metabolism, First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.
    Rationale: Insulin autoimmune syndrome (IAS) is an uncommon disorder characterized by hyperinsulinemic hypoglycemia related to insulin-binding autoantibodies. To the best of our knowledge, we report the first case of a pregnant female with IAS.

    Patient Concerns: The 26-year-old patient with Graves disease and 10 weeks pregnant developed IAS after approximately 6 months treatment with methimazole. Read More

    Ectopic thyrotropin secreting pituitary adenoma concomitant with papillary thyroid carcinoma: Case report.
    Medicine (Baltimore) 2017 Dec;96(50):e8912
    Department of Endocrinology.
    Rationale: Ectopic thyrotropin (TSH)-secreting pituitary adenomas are exceedingly rare. To date, there are only 6 cases reported. Here, we describe an even rarer ectopic TSH-secreting pituitary adenoma (TSH-oma) concomitant with papillary thyroid carcinoma. Read More

    Indications and contraindications to transoral thyroidectomy.
    Ann Thyroid 2017 31;2(5). Epub 2017 Oct 31.
    Division of Head and Neck Endocrine Surgery, Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
    Patient motivation to avoid neck scarring has been a strong impetus in the development of remote access approaches to the thyroid, including transoral robotic or endoscopic thyroidectomy vestibular approach (TOR/ETVA). TOR/ETVA continues to become more prevalent given its early success in North America and the demonstration of its safety and efficacy in Asia. As more surgeons perform this procedure, it is important that specific and uniform indications and contraindications exist to prevent surgical complications due to poor patient selection. Read More

    Abnormal distance of the extralaryngeal bifurcation point of the recurrent laryngeal nerve from the cricothyroid joint.
    J Surg Case Rep 2018 Jan 17;2018(1):rjx257. Epub 2018 Jan 17.
    University Department of Surgery, General and Oncologic Hospital of Kifissia 'Agii Anargiri', Athens, Greece.
    The extralaryngeal bifurcation point of the recurrent laryngeal nerve (RLN) is typically located in a mean distance of 0-2 cm from the cricothyroid joint (CTJ). In the presented case though, the left RLN was unexpectedly identified bifurcating in a mean distance of 7 cm from the left CTJ in a young woman with multinodular goiter during total thyroidectomy. The RLN was carefully exposed throughout its course for the avoidance of iatrogenic injury of the nerval structure. Read More

    Thyroid-associated orbitopathy in patients with thyroid carcinoma: A case report of 5 cases.
    Medicine (Baltimore) 2017 Nov;96(47):e8768
    Department of Internal Medicine.
    Rationale: Thyroid-associated orbitopathy (TAO) is most often seen in patients with autoimmune thyroid disease. Data about TAO occurred in patients with thyroid carcinoma are rare. We give a report of 5 patients to present the clinical characteristics, treatment, and prognosis of this type of case. Read More

    Riedel's thyroiditis: clinical presentation, treatment and outcomes.
    Endocrine 2018 Jan 29. Epub 2018 Jan 29.
    Department of Endocrinology, Metabolism and Diabetes, Karolinska University Hospital, Stockholm, Sweden.
    Background: Riedel´s thyroiditis (RT) is a rare inflammatory disease of the thyroid gland, causing compression and fibrosis of adjacent tissues. Typically the goiter is hard and firm. Hoarseness, dyspnea, and dysphagia may be present. Read More

    Relationship between urine lipid peroxidation, anthropometric parameters and parameters associated with goitre formation in school-age children.
    Arch Med Sci 2018 Jan 19;14(1):30-37. Epub 2017 Dec 19.
    Polish Mother's Memorial Hospital - Research Institute, Lodz, Poland.
    Introduction: Oxidative stress has been implicated in the normal ageing process and the pathogenesis of several diseases, including goitre. The aim of the study was to evaluate the relationship between urine lipid peroxidation (LPO) and anthropometric parameters as well as the parameters associated with goitre formation in children.

    Material And Methods: The subjects included 172 healthy children (93 girls and 79 boys) aged 8-15, divided into 4 age groups - group I (8-9 years), group II (10-11 years), group III (12-13 years) and group IV (14-15 years) - and into 2 groups based on the BSA: the BSA-1 group (≤ 0. Read More

    Thyroid adenolipoma: a case report.
    J Ultrasound 2017 Nov 30. Epub 2017 Nov 30.
    Radiodiagnostic-University Hospital "Policlinico-Vittorio Emanuele", Via Santa Sofia 78, 95123, Catania, Italy.
    Generally, small quantities of adipose tissue is present in the thyroid gland. The adenolipoma of the thyroid gland is considered a rare finding. It consists in a benign, encapsulated neoplasm composed of mature adipose tissue and glandular elements. Read More

    [Results of molecular genetic testing in Russian patients with Pendred syndrome and allelic disorders].
    Genetika 2017 Jan;53(1):88-99
    Pendred syndrome is an autosomal recessive inherited disorder characterized by a combination of sensorineural hearing impairment and euthyroid goiter; its clinical manifestation in children is hardly distinguishable from nonsyndromic hearing loss. Pendred syndrome is one of the most frequent types of syndromic hearing loss. Hearing impairment is accompanied by abnormal development of the bony labyrinth—enlarged vestibular aqueduct (EVA) and occasionally combined with Mondini dysplasia. Read More

    Prevalence and risk factors for hyperthyroidism in Irish cats from the greater Dublin area.
    Ir Vet J 2018 15;71. Epub 2018 Jan 15.
    1Section of Small Animal Clinical Studies, School of Veterinary Medicine, University College Dublin, Belfield, Dublin 4, Ireland.
    Background: Hyperthyroidism is common in older cats. Prevalence varies geographically, but is anecdotally considered low in Ireland. The aim of this study was to document prevalence of hyperthyroidism in older cats in the greater Dublin area of Ireland and to assess environmental and clinical associations for development and identification of the disease. Read More

    Subclinical Hypothyroidism - Whether and When To Start Treatment?
    Open Access Maced J Med Sci 2017 Dec 26;5(7):1042-1046. Epub 2017 Oct 26.
    JZU Dom Zdravlja Podgorica - ZS Nova Varos, Podgorica 20000, Montenegro.
    Subclinical hypothyroidism represents a state with increased values of thyroid stimulating hormone (TSH) and normal values of thyroxine (T4) and triiodothyronine (T3). The disorder is asymptomatic, and the diagnosis is made based on the results of laboratory findings when the level of TSH reaches values above 4.0 mU/l. Read More

    Obviating the need for sternotomy: Safety and effectiveness of microdebrider use for retrosternal goiter.
    Head Neck 2018 Jan 23. Epub 2018 Jan 23.
    Division of Cancer Surgery, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
    Background: Most retrosternal goiter surgical removal can be performed via a transcervical approach. However, it is often a challenging procedure, which might include sternotomy.

    Methods: We describe a surgical technique using a microdebrider for intracapsular volume reduction that precedes an extracapsular thyroidectomy, thereby avoiding the need for sternotomy, with decreased morbidity and risk. Read More

    Rare Undiagnosed Primary Amyloidosis Unmasked During Surgical Treatment of Primary Hyperparathyroidism: A Case Report.
    J Endocr Soc 2018 Feb 3;2(2):112-116. Epub 2018 Jan 3.
    Division of Surgical Oncology and Endocrine Surgery, Department of Surgery, Vanderbilt University Medical Center, Nashville, Tennessee 37232.
    Primary amyloidosis (PA) is a protein deposition disorder that presents with localized or multisystemic disease. The incidence is low in the general public, ranging from three to eight cases per million, and with nonspecific presenting symptoms typically occurring later in life. Due to late presentation, substantial and irreversible damage has usually already occurred by the time of the diagnosis. Read More

    Incidental Detection of a Melanoma by 18F-Fluorocholine PET/CT Performed for Evaluation of Primary Hyperparathyroidism.
    Clin Nucl Med 2018 Jan 19. Epub 2018 Jan 19.
    From the Department of Nuclear Medicine and Radiology, Northwest Clinics, Alkmaar, the Netherlands.
    An 80-year-old woman was evaluated with F-fluorocholine PET/CT in suspicion of a parathyroid adenoma. No focal parathyroid tracer uptake suggestive of adenoma was found, and instead a unilateral multinodular goiter without elevated F-fluorocholine uptake was diagnosed. In addition, focal uptake was found in a cutaneous nodule dorsally on the right shoulder. Read More

    iTRAQ analysis of urinary proteins: Potential use of gelsolin and osteopontin to distinguish benign thyroid goiter from papillary thyroid carcinoma.
    Clin Biochem 2018 Jan 23. Epub 2018 Jan 23.
    University of Malaya Centre for Proteomics Research, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia; Department of Molecular Medicine, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia. Electronic address:
    Background: Benign thyroid goiter (BTG) and papillary thyroid carcinoma (PTC) are often interchangeably misdiagnosed.

    Methods: Pooled urine samples of patients with BTG (n=10), patients with PTC (n=9) and healthy controls (n=10) were subjected to iTRAQ analysis and immunoblotting.

    Results: The ITRAQ analysis of the urine samples detected 646 proteins, 18 of which showed significant altered levels (p<0. Read More

    Quality of Life in Patients Treated with Percutaneous Laser Ablation for Non-Functioning Benign Thyroid Nodules: A Prospective Single-Center Study.
    Korean J Radiol 2018 Jan-Feb;19(1):175-184. Epub 2018 Jan 2.
    Endocrinology Unit, IRCSS San Martino University Hospital-IST, Largo Rosanna Benzi, n°10, I-16132 Genoa, Italy.
    Objective: While many studies have reported that laser ablation (LA) for benign non-fuctioning thyroid nodules is efficacious in reducing nodular volume and neck symptoms, none have described changes in quality of life (QoL). The purpose of this study was to report post-LA changes in QoL in our cohort of patients.

    Materials And Methods: Fourteen patients with benign thyroid nodules were involved in a prospective, single-center study and underwent a single session of LA. Read More

    I-Induced Graves' disease in patients treated for toxic multinodular goitre: systematic review and descriptive analysis.
    J Endocrinol Invest 2018 Jan 20. Epub 2018 Jan 20.
    Endocrinology, Diabetes and Metabolism Unit, Department of Internal Medicine, Hospital of Egas Moniz, Lisbon's Occidental Center of Hospitals, Estrada do Forte do Alto do Duque, 1449-005, Lisbon, Portugal.
    Background: Graves' disease (GD) arising after the treatment of toxic multinodular goitre (TMNG) with radioiodine has long been described but it remained unclear whether GD was in fact iodine induced, its incidence, risk factors, natural history and treatment outcomes.

    Methods: A systematic search using The Cochrane Library, Medline and PubMed Central allowed the pooling of data from 3633 patients with thyroid autonomy, 1340 patients with TMNG, to fill gaps in knowledge, regarding the clinical expression of iodine-induced GD (I-IGD) in adults.

    Results: I-IGD developed in 0-5. Read More

    Rates of unsuspected thyroid cancer in multinodular thyroid disease.
    N Z Med J 2018 01 19;131(1468):69-74. Epub 2018 Jan 19.
    Endocrinologist, Waikato Clinical Campus, University of Auckland, Hamilton.
    Background: Previously the risk of concomitant thyroid cancer in multinodular goitre (MNG) has been reported as approximately 4%. Cancer risk in toxic MNG was often considered lower than for non-toxic MNG, due to a possible protective effect of TSH suppression. However, recent American data suggest an approximately 18% risk of occult malignancy in both toxic and non-toxic MNG. Read More

    Indications for the Surgical Management of Benign Goiter in Adults.
    Dtsch Arztebl Int 2018 Jan;115(1-02):1-7
    Department of Visceral, Thoracic and Vascular Surgery, University Hospital of Giessen and Marburg; Marburg; Department of Nuclear Medicine, University Hospital of Giessen and Marburg; Marburg; German Society for General and Visceral Surgery, Berlin; Department of General and Visceral Surgery, Sana Klinikum Offenbach; Offenbach; Department of General, Visceral and Vascular Surgery, University Hospital of Würzburg; Würzburg; Department of General, Visceral and Endocrine Surgery, Lukaskrankenhaus Neuss; Neuss.
    Background: Thyroidectomy is still three to six times more common in Germany than in the USA, Great Britain, and the Scandinavian countries. Thus, the question is often asked whether thyroidectomy in Germany is being performed for the correct indications.

    Methods: This review is based on studies and guidelines containing information on the indications for surgery in benign goiter and Graves' disease; these publications were retrieved by a systematic literature search in the Medline and Cochrane Library databases (1990-2016). Read More

    The Deposition and Elimination of Glucosinolate Metabolites Derived from Rapeseed Meal in Eggs of Laying Hens.
    J Agric Food Chem 2018 Feb 30;66(6):1560-1568. Epub 2018 Jan 30.
    Institute of Animal Nutrition, Key Laboratory for Animal Disease-Resistance Nutrition of China, Ministry of Education, Sichuan Agricultural University , Chengdu, Sichuan China , 611130.
    This study was to investigate the deposition and elimination of glucosinolate metabolites including 5-vinyl-1,3-oxazolidine-2-thione (5-VOT) and thiocyanate ion (SCN) derived from rapeseed meal (RSM) in hen eggs. During 12 weeks accumulation phase, the serum triiodothyronine, thyronine, blood urea nitrogen, kidney index, and thyroid index linearly increased with the RSM at week 12 (P < 0.05). Read More

    Reference intervals for thyrotropin in an area of Northern Italy: the Pordenone thyroid study (TRIPP).
    J Endocrinol Invest 2018 Jan 16. Epub 2018 Jan 16.
    Endocrinology and Autoimmunity Laboratory, Department of Internal Medicine, IRCCS Azienda Ospedaliera Universitaria San Martino-IST Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy.
    Purpose: Thyrotropin (TSH) is the most accurate marker of thyroid dysfunction in the absence of pituitary or hypothalamic disease. Studies on TSH reference intervals (RIs) showed wide inter-individual variability and prompted an intense debate about the best estimation of TSH RIs.

    Design: We performed a population study on TSH RIs, using current data stored in the laboratory information system (LIS), at the Hospital Department of Laboratory Medicine, Pordenone (Italy), historically an area of mild-moderate iodine deficiency with a relatively high goiter prevalence. Read More

    Cancer Frequency in Retrosternal Goiter.
    Am Surg 2017 Dec;83(12):1390-1393
    Retrosternal goiter prevalence is 5 to 40 per cent according to classifications in goiter series. Goiters with mediastinal extension were reported to be related with higher cancer rates. In our study, we aimed to investigate whether cancer incidence increased in retrosternal goiters compared with the cervical ones. Read More

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