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    Histopathological pattern of thyroid diseases in Zaria: A 10-year review.
    Niger Postgrad Med J 2018 Jan-Mar;25(1):37-42
    Department of Pathology, Ahmadu Bello University Teaching Hospital, Zaria, Kaduna State, Nigeria.
    Context: Majority of the previous studies on thyroid diseases in Northern Nigeria focussed mainly on neoplastic lesions. The non-neoplastic lesions are more common and constitute more public health burdens.

    Aim: To determine the histopathological pattern of thyroid diseases in our region and compare our findings with similar studies in Nigeria and elsewhere. Read More

    Carney complex: a case with thyroid follicular adenoma without a PRKAR1A mutation.
    Surg Case Rep 2018 Apr 17;4(1):34. Epub 2018 Apr 17.
    Department of Digestive and General Surgery, Faculty of Medicine, Shimane University, 89-1 Enya, Izumo, Shimane, 693-8501, Japan.
    Background: Carney complex (CNC) is a very rare disease. Although thyroid lesions are included in the diagnostic criteria for CNC, they are an infrequent occurrence.

    Case Presentation: The patient was a 69-year-old woman who had undergone the removal of a left atrial myxoma 10 years earlier, at the age of 59. Read More

    Role of Diffusion-Weighted Magnetic Resonance (MR) Imaging in Differentiation Between Graves' Disease and Painless Thyroiditis.
    Pol J Radiol 2017 15;82:536-541. Epub 2017 Sep 15.
    Department of Internal Medicine, Mansoura Faculty of Medicine, Mansoura, Egypt.
    Background: To assess the role of diffusion-weighted MR imaging in differentiation between Graves' disease and painless thyroiditis.

    Material/methods: A prospective study was conducted among 37 consecutive patients with untreated thyrotoxicosis (25 female and 12 male; mean age of 44 years) and 15 ageand sex-matched controls. Diffusion-weighted MR imaging of the thyroid gland was performed in patients and controls. Read More

    Thyroid nodules and long-term follow-up among childhood cancer survivors who underwent hematopoietic stem cell transplantation.
    Clin Pediatr Endocrinol 2018 13;27(2):75-79. Epub 2018 Apr 13.
    Department of Endocrinology, Chiba Children's Hospital, Chiba, Japan.
    Thyroid nodules have been observed in childhood cancer survivors (CCS) treated with chemotherapy and radiotherapy. We report four patients with thyroid nodules identified during the long-term follow-up of children who underwent hematopoietic stem cell transplantation (HSCT). The thyroid nodules were diagnosed as adenomatous goiter in all four patients. Read More

    The onset of systemic lupus erythematosus and thyroid dysfunction following Graves’ disease – A case report and literature review.
    Srp Arh Celok Lek 2016 Nov-Dec;144(11-12):639-44
    Introduction: Graves’ disease is a multifactorial autoimmune thyroid disease, with the presence of typical circulating autoantibodies that can activate the thyroid hormone receptors, resulting in hyperthyroidism, goiter, and ophthalmopathy. Systemic lupus erythematosus is a multi-systemic autoimmune disease that involves almost all the organs of the human body and is characterized by autoantibodies formation. Several studies have reported that autoimmune thyroid and rheumatic disorders can present an unusual relationship. Read More

    Assessment of Iodine Nutritional Status of School-Age Children in Kolkata District of West Bengal State in Post-Iodation Scenario.
    J Trop Pediatr 2018 Apr 6. Epub 2018 Apr 6.
    To evaluate the state of iodine nutrition in post-iodation scenario, 3500 children were examined clinically for endemic goitre. Iodine and thiocyanate were measured in 240 urine samples; iodine content in 210 salt samples was measured. Total goitre prevalence was 6. Read More

    Iodine nutrition status and prevalence of abnormal TSH levels in schoolchildren aged 6-7 years in the autonomous community of the Basque Country.
    Endocrinol Diabetes Nutr 2018 Apr 10. Epub 2018 Apr 10.
    Servicio de Endocrinología y Nutrición, Hospital de Sant Joan Despí Moisès Broggi, Sant Joan Despí (Barcelona), España.
    Introduction: An epidemiological study conducted between 1988 and 1992 showed iodine deficiency and endemic goiter in the schoolchildren of the autonomous community of the Basque Country.

    Objectives: 1) To ascertain the iodine nutrition status of schoolchildren aged 6-7 years, and 2) to estimate the prevalence of abnormal TSH levels in capillary blood.

    Population And Methods: The study was conducted on 497 schoolchildren selected by random sampling. Read More

    Diagnostic utility of DREAM gene mRNA levels in thyroid tumours.
    Arch Endocrinol Metab 2018 Apr 5. Epub 2018 Apr 5.
    Laboratório de Genética Molecular do Câncer (Gemoca), Faculdade de Ciências Médicas (FCM), Universidade Estadual de Campinas (Unicamp), Campinas, SP, Brasil.
    Objective: The transcriptional repressor DREAM is involved in thyroid-specific gene expression, thyroid enlargement and nodular development, but its clinical utility is still uncertain. In this study we aimed to investigate whether DREAM mRNA levels differ in different thyroid tumors and how this possible difference would allow the use of DREAM gene expression as molecular marker for diagnostic and/or prognosis purpose.

    Materials And Methods: We quantified DREAM gene mRNA levels and investigated its mutational status, relating its expression and genetic changes to diagnostic and prognostic features of 200 thyroid tumors, being 101 malignant [99 papillary thyroid carcinomas (PTC) and 2 anaplastic thyroid carcinomas] and 99 benign thyroid lesions [49 goiter and 50 follicular adenomas (FA)]. Read More

    Preoperatively undiagnosed papillary thyroid carcinoma in patients thyroidectomized for benign multinodular goiter.
    Arch Endocrinol Metab 2018 Apr 5. Epub 2018 Apr 5.
    Department of Clinical & Experimental Medicine, University Hospital of Messina, Messina, Italy.
    Objective: Incidental thyroid cancers (ITCs) are often microcarcinomas; among them, the most frequent histotype is the papillary one. The purpose of this study was to evaluate the rate of papillary thyroid cancer (PTC) in patients thyroidectomized for benign multinodular goiter.

    Subject And Methods: We retrospectively evaluated the histological incidence of PTC in 207 consecutive patients who, in a 1-year period, underwent thyroidectomy for benign multinodular goiter. Read More

    Morphological Changes Induced by Bipolar Radiofrequency Ablation in Thyroid Nodules - a Preclinical Investigation.
    Eur Endocrinol 2016 Aug 28;12(2):85-88. Epub 2016 Aug 28.
    Belarusian Medical Academy of Post-Graduate Education, Minsk, Belarus.
    Recently, radiofrequency ablation (RFA) has been increasingly used for the treatment of thyroid nodules. However, immediate morphological changes associated with bipolar devices are poorly shown. To present the results of analysis of gross and microscopic alterations in human thyroid tissue induced by RFA delivered through the application of the original patented device. Read More

    [Transoral thyroid and parathyroid surgery : Implementation and evaluation of the transoral endoscopic technique via the vestibular approach (TOETVA)].
    Chirurg 2018 Apr 10. Epub 2018 Apr 10.
    Klinik für Chirurgie, Landesklinikum Wiener Neustadt, Wien, Österreich.
    Background: More than 10 years ago various research groups in Germany first reported the possibility of transoral surgery of the thyroid and parathyroid glands. These were developed and evaluated within the framework of natural orifice transluminal endoscopic surgery (NOTES). While development of these innovative and new techniques that enabled surgery without visible scars did not become well accepted in Europe and America, it led to an optimized transoral endoscopic thyroidectomy vestibular approach (TOETVA), which was implemented particularly in Asia. Read More

    A novel DICER 1 mutation in familial multinodular goitre.
    Clin Endocrinol (Oxf) 2018 Apr 7. Epub 2018 Apr 7.
    Centre for Endocrinology, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, EC1M 6BQ, UK.
    Multinodular goitre (MNG) is a common disease, present in 20% of the general population. It is more frequent in females, elderly patients, and low iodine regions. Genetically linked loci for familial MNG were found on chromosome 14: MNG1, on chromosome Xp22: MNG2 and on chromosome 3 3q26. Read More

    Cyto-morphologic spectrum of thyroid lesions in children.
    Diagn Cytopathol 2018 Apr 6. Epub 2018 Apr 6.
    Department of Pathology, University College of Medical Sciences & GTB hospital, Dilshad Garden, Delhi 110095, India.
    Introduction: Fine needle aspiration (FNA) is routinely used in triaging thyroid lesions in adults. However, role of FNA in pediatric thyroid lesions is less studied.

    Aim And Objective: To study the cyto-morphologic spectrum of thyroid lesions in pediatric population. Read More

    The impact of surgery on quality of life, esophageal motility, and tracheal anatomy and airflow in patients with benign nodular goiter.
    Dan Med J 2018 Apr;65(4)
    Surgery - is it any good for goiter? In patients with goiter the benefits of thyroid surgery have previously rarely been investigated, as only few alternatives existed. However, the increasing evidence of the advantages with non-surgical substitutes with lower costs and preferable risk profiles prompted us to investi-gate the evidence base for thyroid surgery thoroughly. This thesis consists of three published studies investigating the impact of thyroidectomy on: 1) changes in disease-specific quality of life, 2) swallowing symptoms and esophageal motility, and 3) tracheal anatomy and airflow, in a cohort of patients with benign nodular goiter. Read More

    Renal cell metastasis to the thyroid gland: An emerging phenomenon.
    Int J Surg Case Rep 2018 Mar 26;45:104-106. Epub 2018 Mar 26.
    General Surgery, Royal Darwin Hospital, Darwin, 0810, Australia. Electronic address:
    Introduction: Suspected thyroid malignancies are usually assumed to be primary in origin. Rarely, in 1-3% of cases, the tumour arises from a secondary source such as a melanoma or breast carcinoma. There is a growing body of research concerning metastatic spread of renal cell carcinoma to the thyroid gland. Read More

    A 78-Year-Old Man With Historical Goiter.
    J Endocr Soc 2018 Mar 8;2(3):290-292. Epub 2018 Feb 8.
    Diabetology, Endocrinology and Nutrition Department, Hospital European Georges Pompidou (AP-HP), Paris, France.
    The purpose of this paper is to provide description of the natural evolution of an initially operable goitre into unmesurable form in a context of deeply unknown psychiatric disorders initially unknown. Read More

    Prognostic value of long non-coding RNA BLACAT1 in patients with papillary thyroid carcinoma.
    Cancer Cell Int 2018 27;18:47. Epub 2018 Mar 27.
    1Department of Endocrinology and Breast Surgery, the First Affiliated Hospital of Chongqing Medical University, Chongqing, 400043 China.
    Background: Long noncoding RNAs (lncRNAs) have been reported to have potential diagnostic and prognostic values for numerous cancers. However, the plasma expression of lncRNA BLACAT1 and its clinical value in patients with papillary thyroid cancer (PTC) remain unknown.

    Methods: The expression profile of BLACAT1 in 87 PTC patients (case group) and 36 patients with nodular goiter (control group) were investigated by qRT-PCR. Read More

    Iatrogenic hypoparathyroidism after surgery for retrosternal goitre. A single centre retrospective analysis.
    Clin Ter 2018 Mar-Apr;169(2):e67-e70
    Department of Surgical, Oncological and Stomatological Sciences, University of Palermo, Italy.
    Aim: The aim of this study is to assess, retrospectively, the incidence of secondary hypoparathyroidism after total thyroidectomy in patients with retrosternal goitre.

    Material And Methods: From January 2009 to September 2015, 622 patients who undergone total thyroidectomy for goitre, were retrospectively observed. The patients were divided into two group: Group A, including 58 patients with retrosternal goitre and Group B, including 562 patients with in situ goitre. Read More

    A Case Report of Syndromic Multinodular Goitre in Adolescence: Exploring the Phenotype Overlap between Cowden and DICER1 Syndromes.
    Eur Thyroid J 2018 Jan 21;7(1):44-50. Epub 2017 Nov 21.
    Department of Endocrinology and Diabetes, Princess Margaret Hospital for Children, Subiaco, Washington, Australia.
    Background: Hereditary tumour predisposition syndromes may increase the risk for development of thyroid nodules at a young age. We present the case of an adolescent female with Cowden syndrome who had some atypical phenotypic features which overlapped with the DICER1 syndrome.

    Material And Methods: A 17-year-old female presented with a 3-month history of progressive right neck swelling. Read More

    Consequences of bleeding after thyroid surgery - analysis of 7805 operations performed in a single center.
    Arch Med Sci 2018 Mar 17;14(2):329-335. Epub 2016 Oct 17.
    Department and Clinic of General, Gastroenterological and Endocrine Surgery, Wroclaw Medical University, Wroclaw, Poland.
    Introduction: Surgical treatment of thyroid gland diseases is associated with the possibility of severe complications. The most dangerous of them is bleeding. Current studies focus on its risk factors, rather than reoperation-related consequences. Read More

    Histopathological Characterization and Whole Exome Sequencing of Ectopic Thyroid: Fetal Architecture in a Functional Ectopic Gland from Adult Patient.
    Int J Endocrinol 2018 8;2018:4682876. Epub 2018 Feb 8.
    Postgraduate Program in Biotechnology, Universidade Federal de São Paulo (UNIFESP), Pedro de Toledo 669, 040399-032 São Paulo, SP, Brazil.
    Ectopic thyroid results from a migration defect of the developing gland during embryogenesis causing congenital hypothyroidism. But it has also been detected in asymptomatic individuals. This study aimed to investigate the histopathological, functional, and genetic features of human ectopic thyroids. Read More

    Benign Thyroid Diseases and Risk of Thyroid Cancer: A Nationwide Cohort Study.
    J Clin Endocrinol Metab 2018 Mar 23. Epub 2018 Mar 23.
    Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark.
    Context: Thyroid nodules, adenomas, and goiter have consistently been associated with thyroid cancer risk. Few studies have assessed whether thyroid dysfunction and thyroid autoimmunity influence this risk.

    Objective: To examine thyroid cancer risk following diagnoses of a wide range of benign thyroid conditions. Read More

    Evaluation and Management of the Child with Thyrotoxicosis.
    Recent Pat Endocr Metab Immune Drug Discov 2018 Mar 26. Epub 2018 Mar 26.
    Departments of Medicine, Community Health Sciences, and Oncology, The University of Calgary, Calgary, Alberta. Canada.
    Background: Uncontrolled thyrotoxicosis, especially in early infancy, may cause irreversible damage to the central nervous system as well as profound effects on the function of many organs. Thyrotoxicosis has multiple etiologies and treatment depends on the underlying etiology. An accurate diagnosis is essential so that appropriate treatment can be initiated without undue delay. Read More

    TSH evaluation in hypothyroid patients assuming liquid levothyroxine at breakfast or 30 min before breakfast.
    J Endocrinol Invest 2018 Mar 26. Epub 2018 Mar 26.
    Endocrine and Metabolic Unit, Department of Clinical and Experimental Sciences, University of Brescia, c/o 2° Medicina Spedali Civili di Brescia, Piazzale Spedali Civili n°1, 25100, Brescia, Italy.
    Purpose: To compare TSH levels of hypothyroid patients treated with liquid LT4 at breakfast or 30 min before breakfast.

    Patients And Methods: Subjects, aged 18-75 years old, were eligible if they presented hypothyroidism, due to Hashimoto's thyroiditis or after thyroidectomy for proven benign goiter. Seven hundred ninety-eight patients were recruited and enrolled in the study. Read More

    Substernal Goiter: Correlation between Grade and Surgical Approach.
    Am Surg 2018 Feb;84(2):262-266
    Substernal goiter is defined as a thyroid growth beyond the thoracic inlet. Using the cross-section imaging CT system, it can be classified into three grades. The aim of the study was to validate the surgical approach and the occurrence of postoperative complications with substernal goiter extension in our patient population. Read More

    Risk profile analysis and complications after surgery for autoimmune thyroid disease.
    Br J Surg 2018 May 26;105(6):677-685. Epub 2018 Mar 26.
    Department of General, Vascular and Visceral Surgery, Martin Luther University of Halle-Wittenberg, Halle an der Saale, Germany.
    Background: Surgical approaches to autoimmune thyroid disease are currently hampered by concerns over postoperative complications. Risk profiles and incidences of postoperative complications have not been investigated systematically, and studies with sufficient power to show valid data have not been performed.

    Methods: A prospective multicentre European study was conducted between July 2010 and December 2012. Read More

    Thyrotoxic crisis as an acute clinical presentation in a child.
    BMJ Case Rep 2018 Mar 23;2018. Epub 2018 Mar 23.
    Paediatrics, University Hospitals of Leicester Foundation Trust, Leicester, UK.
    A previously well, 4-year-old girl presented with a 4-6 weeks' history of increased appetite, weight loss, tiredness, sleep difficulty, excessive sweating, swelling in the neck and new-onset 'prominent, protruding eyes.' Family history revealed paternal grandmother receiving treatment for hyperthyroidism. Clinical assessment demonstrated features of thyrotoxicosis (tachycardia, warm peripheries, small smooth goitre with no nodules, exophthalmos). Read More

    Differentiation of Benign and Malignant Thyroid Nodules by Using Comb-push Ultrasound Shear Elastography: A Preliminary Two-plane View Study.
    Acad Radiol 2018 Mar 21. Epub 2018 Mar 21.
    Department of Radiology, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN. Electronic address:
    Rationale And Objectives: Low specificity of traditional ultrasound in differentiating benign from malignant thyroid nodules leads to a great number of unnecessary (ie, benign) fine-needle aspiration biopsies that causes a significant financial and physical burden to the patients. Ultrasound shear wave elastography is a technology capable of providing additional information related to the stiffness of tissues. In this study, quantitative stiffness values acquired by ultrasound shear wave elastography in two different imaging planes were evaluated for the prediction of malignancy in thyroid nodules. Read More

    Outcome of Treatment for Medullary Thyroid Carcinoma-a Single Centre Experience.
    Indian J Surg Oncol 2018 Mar 8;9(1):52-58. Epub 2017 Dec 8.
    1Department of Endocrine Surgery, Christian Medical College and Hospital, Paul Brand building (1205), Vellore, Tamil Nadu India.
    We conducted this study to evaluate the demography, clinical presentation, management and outcomes of medullary thyroid carcinoma (MTC) from the Indian context. This was a retrospective study of patients with MTC managed between January 2008 and December 2016. All pertinent data was collected and the results were analysed using STATA (v. Read More

    Sequential high intensity focused ultrasound (HIFU) ablation in the treatment of benign multinodular goitre: an observational retrospective study.
    Eur Radiol 2018 Mar 19. Epub 2018 Mar 19.
    Department of Radiology, The University of Hong Kong Queen Mary Hospital, 102 Pokfulam Road, Hong Kong, SAR, China.
    Objectives: Assessing the efficacy and safety of sequential high-intensity focused ultrasound (HIFU) ablation in a multinodular goitre (MNG) by comparing them with single HIFU ablation.

    Methods: One hundred and four (84.6%) patients underwent single ablation of a single nodule (group I), while 19 (15. Read More

    Potential Use of 1-25-dihydroxyvitamin D in the Diagnosis and Treatment of Papillary Thyroid Cancer.
    Med Sci Monit 2018 Mar 19;24:1614-1623. Epub 2018 Mar 19.
    Department of Thyroid Surgery, The First Hospital of China Medical University, Shenyang, Liaoning, China (mainland).
    BACKGROUND Low levels of 1-25-dihydroxyvitamin D3 [1,25(OH)2D3] in serum may be a risk factor for several tumor types. Also, high cathelicidin antimicrobial peptide (CAMP) expression is regarded to be important against tumor progression. We evaluated the potential importance of 1,25(OH)2D3 in the diagnosis and treatment of papillary thyroid cancer (PTC). Read More

    Expression of human telomerase reverse transcriptase (hTERT) in thyroid neoplasms.
    J BUON 2018 Jan-Feb;23(1):229-233
    Health Sciences University, Antalya Education and Research Hospital, Department of Pathology, Antalya, Turkey.
    Purpose: Distinction of thyroid neoplasms that include papillary carcinoma (PC) and follicular carcinoma (FC) from benign thyroid neoplasms can be performed successfully by histopathologic examination in most of the cases. However, in some cases it may be difficult to distinct PC and FC as well as FC and follicular adenoma (FA) and also FA and the dominant nodule of multinodular goiter (MNG) histopathologically. In this study, we aimed to determine the role of expression of the human telomerase reverse transcriptase (hTERT) in the distinction of thyroid neoplasms and its relation with prognostic factors by immunohistochemical methods. Read More

    Severe Hyperthyroidism Complicated by Agranulocytosis Treated with Therapeutic Plasma Exchange: Case Report and Review of the Literature.
    Case Rep Endocrinol 2018 10;2018:4135940. Epub 2018 Jan 10.
    Department of Internal Medicine, University of Mississippi Medical Center, Jackson, MS, USA.
    Aim: To present a case of Graves' disease complicated by methimazole induced agranulocytosis treated with therapeutic plasma exchange (TPE) and review of the literature.

    Case Presentation: A 21-year-old patient with a history of Graves' disease presented to the endocrine clinic. His history was significant for heat intolerance, weight loss, and tremors. Read More

    Thyroid Disease Around the World.
    Otolaryngol Clin North Am 2018 Mar 13. Epub 2018 Mar 13.
    Department of Head and Neck Surgery, Division of Surgery, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 1445, Houston, TX 77030, USA. Electronic address:
    Thyroid disease is one of the most common pathologies in the world, with two of the most clinically important subgroups being iodine deficiency and thyroid goiter, and thyroid cancer. This review looks at the current state of thyroid disease in the world and evaluates the future direction in terms of thyroid disease treatment and prevention. Several of the most impactful epidemiologic studies are presented and analyzed, as well as a brief overview of the current socioeconomic burden of disease. Read More

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