Search Our Scientific Publications & Authors

Pan Afr Med J 2018 2;31:72. Epub 2018 Oct 2.

Service d'Hépato-Gastroentérologie de l'Hôpital Aritide Le Dantec, Dakar, Sénégal.

Hepatic impairment is common during hyperthyroidism. It is most often asymptomatic. Hyperthyroidism revealed by jaundice has been rarely described in the literature. Read More

Niger J Surg 2019 Jan-Jun;25(1):64-69

Department of Surgery, Obafemi Awolowo University Teaching Hospitals Complex, Ile Ife, Osun State, Nigeria.

Background: The principles of safe and efficient thyroid surgery had been established and the technique has remained the same for over the century without any major significant changes. The introductions of electrosurgical devices constitute a major shift in the technique of thyroid surgery.

Objective: We present our early experience with the use of LIGASURE vessel sealing system for the procedure of thyroidectomy. Read More

Am J Clin Nutr 2019 Apr 17. Epub 2019 Apr 17.

Centre for Global Child Health, Hospital for Sick Children, Toronto, Canada.

Background: Micronutrient malnutrition is highly prevalent in low- and middle-income countries (LMICs) and disproportionately affects women and children. Although the effectiveness of large-scale food fortification (LSFF) of staple foods to prevent micronutrient deficiencies in high-income settings has been demonstrated, its effectiveness in LMICs is less well characterized. This is important as food consumption patterns, potential food vehicles, and therefore potential for impact may vary substantially in these contexts. Read More

BMJ Case Rep 2019 Apr 16;12(4). Epub 2019 Apr 16.

Internal Medicine, Centro Hospitalar e Universitario de Coimbra EPE, Coimbra, Portugal.

Benign multinodular goitre is a common illness. When accompanied by obstructive symptoms, such as dyspnoea, it carries an indication for surgery. Benign multinodular goitres rarely cause acute airway obstruction. Read More

Case Rep Surg 2019 12;2019:3821767. Epub 2019 Mar 12.

Department of Surgery, The Aga Khan University Hospital, Karachi, Pakistan.

Retrosternal extension of goiter is one of the most common types of masses in the superior mediastinum. These types of goiters classically present with compressive symptoms such as dyspnea, dysphonia, dysphagia, or sleep apnea. Surgical treatment with a total thyroidectomy and complete removal of the intrathoracic portion of thyroid is the gold standard treatment. Read More

J Endocrinol Invest 2019 Apr 15. Epub 2019 Apr 15.

Department of Endocrinology and Internal Medicine, Medical University of Gdansk, Debinki 7 Street, 80-952, Gdansk, Poland.

Purpose: To find endocrinological disturbances in impressionism.

Patients And Methods: Analysis of "La Toilette" painting of Frederice Bazille.

Results: We present a masterpiece work of Frederic Bazille "La Toilette" where a large goiter is visible. Read More

MMW Fortschr Med 2019 Apr;161(7):38-43

Med. Klinik und Poliklinik IV, Klinikum der Univ. München, Campus Großhadern und Campus Innenstadt, München, Deutschland.

Med Sci Monit 2019 Apr 16;25:2785-2791. Epub 2019 Apr 16.

Graduate School of Medicine, Nanchang University, Nanchang, Jiangxi, China (mainland).

BACKGROUND This study aimed to identify altered exosome circular RNA (circRNA) in the serum of patients with papillary thyroid carcinoma using high-throughput sequencing. MATERIAL AND METHODS Serum was collected from three patients with papillary thyroid carcinoma and three patients with a benign thyroid goiter. Exosomes were isolated using an exosome isolation kit and confirmed by transmission electron microscopy. Read More

Eur J Endocrinol 2019 Apr 1. Epub 2019 Apr 1.

C Tseng, Department of Internal Medicine, National Taiwan Unvisersity Hospital, Taipei, 100, Taiwan.

Background: Whether metformin might affect the risk of benign nodular goiter in patients with type 2 diabetes mellitus has not been investigated.

Methods: Patients with new-onset type 2 diabetes mellitus during 1999-2005 were enrolled from Taiwan's National Health Insurance database. Analyses were conducted in a propensity score matched-pairs of 20,048 ever users and 20,048 never users of metformin. Read More

Indian Dermatol Online J 2019 Mar-Apr;10(2):162-164

Department of Skin and STD, North Eastern Indira Gandhi Regional Institute of Health and Medical Sciences, Mawdiangdiang, Shillong, Meghalaya, India.

Localized myxedema is most commonly described in patients with hyperthyroidism, especially Graves' disease. Although pretibial myxedema generally appears as indurated plaques on the shins, it has also been rarely reported in other areas such as the face, shoulders, arms, and abdomen. We report a rare case of preradial myxedema in a hyperthyroid patient who was taking thyroxine post thyroidectomy for goiter. Read More

Acta Diabetol 2019 Apr 12. Epub 2019 Apr 12.

Department of Medical Sciences, University of Turin, Corso Dogliotti 14, 10126, Turin, Italy.

Nuklearmedizin 2019 Apr 11. Epub 2019 Apr 11.

Department of Nuclear Medicine, University Hospital of Cologne.

Aim: Thyroid hemiagenesis (TH) is a rare congenital anomaly in which one thyroid lobe fails to develop. We describe our experience with at least 13 patients presenting with TH at our department.

Methods: We retrospectively analysed patients with TH, who had been referred primarily to our clinic between 2004 and 2010. Read More

Br J Surg 2019 May;106(6):700

University of Rome Sapienza, Rome, Italy.

, Published online in Wiley Online Library (www.bjs.co. Read More

Thyroid 2019 Apr 11. Epub 2019 Apr 11.

Centre Hospitalier Universitaire de Reims, 26992, Service d'Endocrinologie - Diabète - Nutrition, Reims, Champagne-Ardenne, France.

Background: Thyroid-stimulating hormone (TSH) receptor (TSHR) antibodies (TRAb) can be present in chronic autoimmune thyroiditis. Transplacental TRAb transfer can lead to fetal thyroid dysfunction and serious complications.

Patient Findings: We report the case of a woman with autoimmune hypothyroidism and extremely high TRAb levels, with blocking and stimulating activities (biological activities characterized with Chinese hamster ovary cells expressing TSHR). Read More

Zhong Nan Da Xue Xue Bao Yi Xue Ban 2019 Mar;44(3):322-328

Department of Ophthalmology, Xiangya Hospital, Central South University, Changsha 410008, China.

Objective: To investigate the values of orbital single photon emission computed tomography/computerized tomography (SPECT/CT) with 99mTc-diethylene triamine pentaacetic acid (99mTc-DTPA) on the evaluation of lacrimal gland inflammation in patients with thyroid associated ophthalmopathy (TAO).
 Methods: A total of 58 TAO patients were retrospectively recruited for this study, all of whom were categorized into all active group and all inactive group based on the clinical active score (CAS). Another 12 patients with the negative images on SPECT/CT served as a normal control group (NC). Read More

J Clin Med 2019 Apr 8;8(4). Epub 2019 Apr 8.

Department of Visceral-, Vascular and Endocrine Surgery, University Medical Centre Halle, 06120 Halle, Germany.

Background: To evaluate the current indications, resection strategies and short-term outcomes of surgery for benign goitre in a country with endemic goitre.

Methods: Data of patients who underwent surgery for benign goitre were retrieved from the prospective StuDoQ/Thyroid registry and retrospectively analysed regarding the patient's demographics, indications for surgery, surgical procedures, histology, and perioperative outcomes.

Results: In a 15-month period, 12,888 patients from 83 departments underwent thyroid resections for benign conditions. Read More

Thyroid 2019 Apr 9. Epub 2019 Apr 9.

the 1st hospital of China Medical University, Institute of Endocrinology, Department of Endocrinology and Metabolism , 155,Nanjing Bei Street , Heping District , Shenyang, Liaoning, China , 110001.

Background: There is growing evidence that sphingosine-1-phosphate (S1P), a pleiotropic bioactive sphingolipid metabolite synthesized intracellularly by two closely related sphingosine kinases (SphK), SphK1 and SphK2, is involved in inflammation. However, the role of SphKs/S1P/S1P receptors (S1PRs) in autoimmune thyroiditis (AIT) has not been studied to date.

Method: This study examined whether SphK1/S1P/S1PR1 signaling is aberrantly altered in thyroid tissues and serum of both AIT patients and a spontaneously autoimmune thyroiditis (SAT) mouse model. Read More

BJS Open 2019 Apr 26;3(2):174-179. Epub 2018 Dec 26.

Department of Otolaryngology - Head and Neck Surgery Guy's and St Thomas' NHS Foundation Trust London UK.

Background: Sternotomy and lateral thoracotomy are required infrequently to remove an intrathoracic goitre (ITG). As few studies have explored the need for an extracervical approach (ECA), the aim of this study was to examine this in a large cohort of patients.

Methods: A prospective database of all patients who had surgery for ITG between 2004 and 2016 was interrogated. Read More

Case Rep Pathol 2019 10;2019:9890716. Epub 2019 Mar 10.

Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA.

The thyroid gland is an uncommon site of metastatic disease. Renal cell carcinoma is the most common primary source, while metastasis from breast carcinoma is very rare. However, given that thyroid nodules are more common in women, and women with a history of breast cancer are at higher risk of developing thyroid cancer, the possibility of metastatic breast carcinoma must be considered when evaluating a thyroid nodule. Read More

Zhonghua Bing Li Xue Za Zhi 2019 Apr;48(4):288-292

Department of Pathology, Beijing Hospital, National Center of Gerontology, Beijing 100730, China.

To investigate the prevalence of BRAF V600E mutation in thyroid nodules and to analyze the relationship between BRAF V600E mutation and various clinicopathological features. BRAF V600E mutant gene test was done in 463 cases of thyroid nodules collected from April 2015 to July 2018 in Beijing Hospital. Pathologic sections of 444 cases of papillary thyroid carcinoma were reviewed and clinical information was collected. Read More

Endocrine 2019 Apr 6. Epub 2019 Apr 6.

Department of Endocrinology, Connolly Hospital, Blanchardstown, Co Dublin, Ireland.

Purpose: The overdiagnosis of thyroid nodules and indolent thyroid cancers represents an increasing burden on health services, with thyroid ultrasound (US) imaging often representing the initial entry point into the thyroid nodule diagnostic pathway. The aim of this study was to retrospectively review thyroid US referrals to a single Irish hospital to determine if the stated indications for imaging had been appropriate, to review the results of the scans, and to assess the follow-up required in each case.

Methods: Patient demographics, scan indications, results, and outcomes were retrospectively reviewed for all patients undergoing thyroid ultrasound from 2012 to 2016. Read More

BMC Endocr Disord 2019 Apr 5;19(1):36. Epub 2019 Apr 5.

Department of Occupational Medicine, Tainan Municipal Hospital (managed by Show Chwan Medical Care Corporation), Tainan, Taiwan. No. 670, Chongde Road, East District, Tainan, Taiwan.

Background: This study aimed to investigate the occurrence and risk factors of thyroid dysfunction (TD) in patients with chronic hepatitis C (CHC) infection in Taiwan.

Methods: The data in this study were obtained from the Taiwan National Health Insurance Research (Taiwan NHIR) database between 2001 and 2013. CHC patients treated with pegylated interferon/ribavirin (PEG-IFN/RBV) were enrolled as case patients, and nontreated CHC patients were enrolled as controls and were matched at a control:case ratio of 3:1 by index date, age (± 3 years), and sex. Read More

Acta Neuropathol 2019 Apr 5. Epub 2019 Apr 5.

Department of Pathology, Boston Children's Hospital, Harvard Medical School, 300 Longwood Ave, Bader 104, Boston, MA, 02115, USA.

DICER1 syndrome is a rare tumor predisposition syndrome with manifestations that predominantly affect children and young adults. The syndrome is typically caused by heterozygous germline loss-of-function DICER1 alterations accompanied on the other allele by somatic missense mutations occurring at one of a few mutation hotspots within the sequence encoding the RNase IIIb domain. DICER1 encodes a member of the microRNA biogenesis machinery. Read More

Radiologe 2019 Apr 4. Epub 2019 Apr 4.

Praxis für Endokrinologie und Nuklearmedizin, Brückenstraße 21, 69210, Heidelberg, Deutschland.

Background: Adequate intake of iodine is essential for normal thyroid function. However, sudden exposure to high amounts of iodine may cause thyroid dysfunction.

Aim: The aims of this paper are to summarize the literature on the effects of iodinated contrast medium (CM) on thyroid function, the risk to develop CM-induced hyper- and hypothyroidism, and to describe procedures for clinical practice regarding diagnosis, prevention, and treatment of CM-induced hyperthyroidism. Read More

Thyroid Res 2019 23;12. Epub 2019 Mar 23.

Department of Clinical Pharmacy, Lecturer and Preceptor of Clinical Pharmacy, UOG University of Gondar College of Medicine and Health Sciences, School of Pharmacy, Gondar, Ethiopia.

Background: Thyrotoxicosis is a clinical state that results from inappropriately high thyroid hormone action in tissues. Although it is one of the common endocrine disorders, there is scarcity of data on the management of thyrotoxicosis in Africa, particularly in Ethiopia. The aim of this study was to investigate treatment outcomes and determinants of treatment outcomes among hyperthyroid patients on antithyroid drugs attending a teaching hospital in Ethiopia. Read More

PLoS One 2019 4;14(4):e0214927. Epub 2019 Apr 4.

Ethiopian Public Health Institute, Addis Ababa, Ethiopia.

Background: Goiter is a major public health problem in Ethiopia. Even though there were studies done on goiter in Ethiopia, there was little evidence in the eastern part of the country. Therefore, the aim of this study was to assess the prevalence of goiter and its associated factors among school-age children in Anchar district of Eastern Ethiopia. Read More

Cesk Patol 2019 ;55(1):13-23

Fine-needle aspiration biopsy (FNAB) has become an established procedure for the basic examination of thyroid nodules, which remain common in our population. The widely used Bethesda system for reporting thyroid cytopathology has undoubtedly contributed to the understanding among clinicians and cytopathologists. Since its publication in 2010, the systems overall applicability has been tested by many studies and reclassification of follicular thyroid tumours has occurred. Read More

J Stroke Cerebrovasc Dis 2019 Mar 29. Epub 2019 Mar 29.

Department of Neurology, Leeds Teaching Hospitals NHS Trust, LS1 3EX, United Kingdom.

Ischaemic stroke secondary to isolated internal carotid artery thrombus without risk factors is uncommon. A 55-year-old woman presented to the acute stroke unit with acute right middle cerebral artery territory infarction secondary to right internal carotid artery occlusion. There were no risk factors for cerebrovascular disease, but mediastinal imaging showed the presence of a large retrosternal goitre which was displacing the mediastinal structures including the brachiocephalic and common carotid artery. Read More

Sci Rep 2019 Apr 1;9(1):5410. Epub 2019 Apr 1.

Department of Obstetrics and Gynecology, Eulji University College of Medicine, Nowon Eulji Medical Center, Seoul, Republic of Korea.

The exact mechanism of endometriosis is unknown. The recommendation system (RS) based on item similarities of machine learning has never been applied to the relationship between diseases. The study aim was to identify diseases associated with endometriosis by applying RS based on item similarities to insurance data in South Korea. Read More

Diagnosis (Berl) 2019 Mar 30. Epub 2019 Mar 30.

Department of Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.

Background Although the most common cause of thyrotoxicosis is Graves' disease, the determination of the cause of thyrotoxicosis is important for establishing appropriate management. Diagnosis of surreptitious ingestion of thyroid hormones or factitious thyrotoxicosis often presents a difficult challenge especially in a patient with previously diagnosed Graves' disease. The objective of this report was to demonstrate various approaches to support the diagnosis of factitious thyrotoxicosis. Read More

J Coll Physicians Surg Pak 2019 Apr;29(4):353-355

Department of General Surgery, Abant Izzet Baysal University Hospital, Bolu, Turkey.

Objective: To determine the frequency of papillary thyroid micro-carcinoma (PTMC) in multinodular goiter (MNG) surgery, as well as in opposite thyroid lobule of the dominant nodule.

Study Design: Descriptive study.

Place And Duration Of Study: General Surgery Department, Abant Izzet Baysal University Hospital, between January 2010 and December 2016. Read More

P R Health Sci J 2019 Mar;38(1):60-63

Abant Izzet Baysal University Hospital, Bolu, Turkey.

Objective: Significant amount of thyroid nodules are malignant. Inflammation plays crucial role in the pathogenesis of many disorders, including cancer. Neutrophil to lymphocyte ratio (NLR), has been suggested as an index of inflammatory response and association between increased NLR and cancer has also been reported. Read More

Eur Radiol 2019 Mar 27. Epub 2019 Mar 27.

Department of Radiology, The University of Hong Kong, Hong Kong, SAR, China.

Objective: To assess whether perithyroidal lignocaine infusion (PLI) could provide additional analgesia in high-intensity focused ultrasound (HIFU) treatment of benign thyroid nodules for patients already receiving their usual intravenous doses of Pethidine and Diazemuls.

Methods: Two hundred and five patients who underwent HIFU ablation for a benign thyroid nodule were analyzed. Among them, 104 (50. Read More

Pan Afr Med J 2018 20;31:43. Epub 2018 Sep 20.

Service d'Oto-Rhino-Laryngologie, Hôpital Militaire Avicenne, Marrakech, Maroc.

Hyperthyroidism includes several diseases characterized by high level of circulating thyroid hormones. Thyroidectomy is one of the main treatment options. We conducted a retrospective study to evaluate the epidemiological, clinical, therapeutic, evolutionary features of patients who had undergone surgery for hyperthyroidism in the ENT Department at the Avicenne Military Hospital in Marrakech. Read More

Endocr J 2019 Mar 28. Epub 2019 Mar 28.

Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan.

Since there have been few reports on the long-term prognosis of Graves' hyperthyroidism, the prognosis of 549 Graves' hyperthyroidism patients initially treated with thionamide and followed for >8 (range: 8.6-36.4) years was studied, evaluating the change in the TSH binding inhibitor immunoglobulin activity (TBII). Read More

Int J Hyperthermia 2019 26;36(1):376-382. Epub 2019 Mar 26.

aa Division of Interventional Radiology , IEO, European Institute of Oncology IRCCS , Milan , Italy.

Benign thyroid nodules are a common clinical occurrence and usually do not require treatment unless symptomatic. During the last years, ultrasound-guided minimally invasive treatments (MIT) gained an increasing role in the management of nodules causing local symptoms. In February 2018, the Italian MIT Thyroid Group was founded to create a permanent cooperation between Italian and international physicians dedicated to clinical research and assistance on MIT for thyroid nodules. Read More

J Dairy Sci 2019 Mar 20. Epub 2019 Mar 20.

Department of Agronomy, Food, Natural Resources, Animals and Environment, University of Padova, Viale dell'Università 16, 35020 Legnaro (PD), Italy.

Adequate milk consumption significantly contributes to the achievement of human iodine recommended daily intake, which ranges from 70 µg/d for infants to 200 µg/d for lactating women. The fulfilment of iodine recommended daily intake is fundamental to prevent serious clinical diseases such as cretinism in infants and goiter in adults. In the present study iodine content was measured in raw and processed commercial cow milk, as well as in raw buffalo, goat, sheep, and donkey milk. Read More

Wiad Lek 2019 ;72(2):267-270

Hygiene and Ecology Institute of Bogomolets National Medical University, Kyiv, Ukraine.

Objective: Introduction: It is proved that some groups of fungicides and herbicides are capable of affecting the thyroid gland, provoking its growth, leading to a compensatory change in the activity of the hormones synthesis. Therefore, the presence of their residual amounts in plant may affect the level of thyroid gland pathology. The aim of the work was to analyze the influence of pesticide application on the Ukrainian child population morbidity with thyroid diseases in the period from 2001 to 2014. Read More

Rev Esp Patol 2019 Apr - Jun;52(2):81-86. Epub 2018 Nov 1.

Complejo Asistencial Universitario Leon, Leon, Spain.

When a patient with a previous history of neoplasm presents with a thyroid lesion, the possibility of it being metastatic should always be considered. In this series, we present the clinicopathological and immunohistochemical features of the thyroid metastases diagnosed in our department over the past 30 years. Here we present eight thyroidal metastases from clear cell renal cell carcinoma (ccRCCC), including a tumor to tumor metastasis, the patients being 2 men and 6 women with a median age of 62 years. Read More

J Ultrasound Med 2019 Mar 21. Epub 2019 Mar 21.

Department of Interventional Ultrasound, Chinese PLA General Hospital, Beijing, China.

Objectives: To preliminarily evaluate the safety, effectiveness, and feasibility of microwave ablation (MWA) for substernal goiter (SSG) in select patients and to provide a relevant treatment reference for further studies.

Methods: From April 2017 to December 2017, 10 patients with SSG were treated by MWA. All patients were followed for at least 3 months to observe the therapeutic effects and complications. Read More

J Biomed Opt 2019 Mar;24(3):1-9

University of Texas at Dallas, Department of Bioengineering, Richardson, Texas, United States.

For patients undergoing surgical cancer resection of squamous cell carcinoma (SCCa), cancer-free surgical margins are essential for good prognosis. We developed a method to use hyperspectral imaging (HSI), a noncontact optical imaging modality, and convolutional neural networks (CNNs) to perform an optical biopsy of ex-vivo, surgical gross-tissue specimens, collected from 21 patients undergoing surgical cancer resection. Using a cross-validation paradigm with data from different patients, the CNN can distinguish SCCa from normal aerodigestive tract tissues with an area under the receiver operator curve (AUC) of 0. Read More

Ann N Y Acad Sci 2019 Mar 20. Epub 2019 Mar 20.

Human Nutrition Laboratory, Institute of Food, Nutrition, and Health, ETH Zurich, Zurich, Switzerland.

Iodine is essential for thyroid hormone synthesis. High iodine intakes are well tolerated by most healthy individuals, but in some people, excess iodine intakes may precipitate hyperthyroidism, hypothyroidism, goiter, and/or thyroid autoimmunity. Individuals with preexisting thyroid disease or those previously exposed to iodine deficiency may be more susceptible to thyroid disorders due to an increase in iodine intake, in some cases at intakes only slightly above physiological needs. Read More

Life Sci 2019 Apr 16;223:166-173. Epub 2019 Mar 16.

Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Science, Tehran, Iran. Electronic address:

Aims: Mutations of BRAF oncogene are considered to contribute in the invasiveness and poor clinicopathologic features of papillary thyroid cancer (PTC). As a step towards understanding the underlying molecular mechanisms of this contribution, we aimed to examine the association of four microRNAs' (miR-222, -137, -214, -181b) levels with BRAFV600E and clinicopathological features in PTC tissues and fine needle aspiration (FNA) specimens.

Methods: In total, 56 PTC and 27 benign with multinodular goiter tissue samples, 95 FNA samples, and B-CPAP and HEK293 cell lines were examined. Read More

BMC Cancer 2019 Mar 18;19(1):245. Epub 2019 Mar 18.

Department of Pathology, National Cancer Center Hospital, Tokyo, Japan.

Background: Fine-needle aspiration (FNA) is the most reliable method for diagnosing thyroid nodules; however, some features such as atypia of undetermined significance or follicular lesion of undetermined significance can confound efforts to identify malignancies. Similar to BRAF, cyclin D1 may be a strong marker of cell proliferation.

Methods: One hundred two patients with thyroidal nodule were enrolled in this prospective study. Read More

Asia Pac J Clin Oncol 2019 Mar 18. Epub 2019 Mar 18.

Medical Biochemistry Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt.

Objectives: This study aimed at investigating the clinical significance of CEP78 and WDR62 in differentiated thyroid carcinoma (DTC). This study also aimed at finding predictors that help in detecting patients with DTC who have high risk for lateral lymph node metastasis (LNM).

Methods: Quantitative real-time polymerase chain reaction (RT-qPCR) was performed to examine CEP78, and WDR62 mRNA expressions in 40 tissue specimens of DTC, and 40 goiter tissue specimens. Read More

Medicine (Baltimore) 2019 Mar;98(11):e14862

Department of Internal Medicine, National Taiwan University Hospital.

Insulin-like growth factor 1 (IGF-1) has a molecular structure similar to that of insulin. As an essential mediator of growth hormone, IGF-1 plays a vital role in growth of children and anabolic effects of adults. We evaluated the serum levels of IGF-1 in patients with hyperthyroidism or euthyroidism. Read More

Front Endocrinol (Lausanne) 2019 1;10:134. Epub 2019 Mar 1.

Department of Cell and Developmental Biology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.

Thyroid cancer is the most common endocrine cancer with predominant prevalence of papillary thyroid cancer (PTC) histotype. MAPK signaling genetic alterations are frequent in PTC, affecting more than 80% of cases. These alterations constitutively activate MAPK signaling cross-regulating different pro-oncogenic pathways. Read More

Front Endocrinol (Lausanne) 2019 1;10:131. Epub 2019 Mar 1.

Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan.

Patients with acromegaly are at increased risk of developing certain tumors, including goiter and thyroid nodules, and occasionally autonomous thyroid nodules. A 53-year-old woman presented at our hospital with untreated acromegaly. She had typical physical features of acromegaly with pituitary adenoma, and thyrotoxicosis with thyroid-stimulating hormone suppression was also confirmed. Read More

Cancer Manag Res 2019 25;11:1829-1841. Epub 2019 Feb 25.

Chronic Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran,

Introduction: Thyroid cancer (TC) is an important common endocrine malignancy, and its incidence has increased in the past decades. The current TC diagnosis and classification tools are fine-needle aspiration (FNA) and histological examination following thyroidectomy. The metabolite profile alterations of thyroid cells (oncometabolites) can be considered for current TC diagnosis and management protocols. Read More

Eur Ann Otorhinolaryngol Head Neck Dis 2019 Mar 14. Epub 2019 Mar 14.

Department of Otolaryngology-Head and Neck Surgery, Galilee Medical Center, Bar-Ilan University, Faculty of Medicine, Galilee, Israël.

Introduction: Deep vein thrombosis of the upper-extremity (ueDVT) is often caused by trauma to the subclavian vein, central venous line and hypercoagulation disorders.

Case Report: We present a case of a ueDVT due to retrosternal goiter compressing the right brachiocephalic vein. Low molecular weight heparin was initiated subcutaneously and fluid was aspirated from the thyroid cyst causing an immediate improvement. Read More