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    [RET/PTC rearrangement affects multifocal formation of papillary thyroid carcinoma].
    Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2017 Jun;52(6):435-439
    Department of Head and Neck Surgery, Sun Yat-Sen University Cancer Center, Guangzhou 510060, China.
    Objective:RET/PTC gene rearrangement can lead to aberrant activation of tyrosine kinase receptors, which is a common mutation in papillary thyroid carcinoma (PTC). This study focuses on the association of RET/PTC rearrangements with PTC clinical factors. Methods: From January 2011 to December 2013, a total of 114 patients with PTC were enrolled in this study. Read More

    Prenatal Diagnosis of Fetal Goitrous Hypothyroidism in a Euthyroid Mother: A Management Challenge.
    J Ultrasound Med 2017 Jun 20. Epub 2017 Jun 20.
    Department of Obstetrics and Gynecology, Strasbourg University Hospital, Schiltigheim, France.
    Although rare, congenital hypothyroidism with a goiter can jeopardize fetal and neonatal outcomes. Prenatal invasive procedures may decrease perinatal morbidity, but indications are still controversial. We report a case of fetal goitrous hypothyroidism diagnosed at 22 weeks' gestation in an euthyroid mother. Read More

    Maternal autoimmune disorders and fetal defects.
    J Matern Fetal Neonatal Med 2017 Jun 18:1-9. Epub 2017 Jun 18.
    a Fetal Medicine Research Institute , King's College Hospital , London , UK.
    Maternal autoantibodies can cross the placenta and cause fetal damage. This article summarizes the development and management of fetal thyroid goiter in response to maternal Graves' disease and/or its treatment with antithyroid medication, fetal heart block due to maternal anti-Ro and anti-La antibodies, fetal athrogryposis multiplex congenita in association with maternal myasthenia gravis and fetal brain hemorrhage due to maternal autoimmune thrombocytopenia. Read More

    Homozygous DUOXA2 mutation (p.Tyr138(*)) in a girl with congenital hypothyroidism and her apparently unaffected brother: Case report and review of the literature.
    Endocr J 2017 Jun 16. Epub 2017 Jun 16.
    Department of Pediatrics, Keio University School of Medicine, Tokyo 160-8582, Japan.
    Mutations in DUOXA2, encoding dual oxidase maturation factor 2, is a rare genetic cause of congenital hypothyroidism. Only four biallelic DUOXA2 mutation carriers have been described to date. This study was conducted to report the clinical and genetic findings of a DUOXA2 mutation-carrying family, and to review the previously reported cases. Read More

    Retrograde Thyroidectomy for preservation of the External Branch of the Superior Laryngeal Nerve: A case series.
    Int J Surg Case Rep 2017 May 15. Epub 2017 May 15.
    Department of Clinical Surgical Sciences, The University of West Indies, St Augustine, Trinidad and Tobago.
    Background: The external branch of the Superior Laryngeal nerve (EBSLN) is at high risk of injury in surgery for large multinodular goitre (MNG) since the upper pole is high in the neck, well cephalad to the EBSLN. We present a technique of drawing the lobe caudally by retrograde thyroidectomy in order to minimize nerve injury.

    Design & Method: All patients having surgery for benign MNG were included. Read More

    Intrauterine death following intraamniotic triiodothyronine and thyroxine therapy for fetal goitrous hypothyroidism associated with polyhydramnios and caused by a thyroglobulin mutation.
    Endocrinol Diabetes Metab Case Rep 2017 7;2017. Epub 2017 Jun 7.
    University of Cambridge Metabolic Research Laboratories, Wellcome Trust-Medical Research Council Institute of Metabolic Science, Addenbrooke's Hospital, CambridgeUK.
    In the absence of maternal thyroid disease or iodine deficiency, fetal goitre is rare and usually attributable to dyshormonogenesis, for which genetic ascertainment is not always undertaken in the UK. Mechanical complications include tracheal and oesophageal compression with resultant polyhydramnios, malpresentation at delivery and neonatal respiratory distress. We report an Indian kindred in which the proband (first-born son) had congenital hypothyroidism (CH) without obvious neonatal goitre. Read More

    Endemic goitre and hypothyroidism in an adult female patient dependent on total parenteral nutrition.
    Endocrinol Diabetes Metab Case Rep 2017 7;2017. Epub 2017 Jun 7.
    Departments of Endocrinology.
    We present the case of a thirty-year-old female patient who was referred to the endocrinology team with an enlarging goitre and biochemical hypothyroidism. She had been dependent on total parenteral nutrition for the previous six years as a result of intestinal failure thought to be caused by possible underlying mitochondrial disease. The patient also suffers from a Desmin myopathy, and at present, the exact aetiology behind her intestinal failure is not certain. Read More

    PTEN, DICER1, FH, and Their Associated Tumor Susceptibility Syndromes: Clinical Features, Genetics, and Surveillance Recommendations in Childhood.
    Clin Cancer Res 2017 Jun;23(12):e76-e82
    Department of Human Genetics and Research Institute, McGill University Health Centre, McGill University, Montreal, Québec, Canada.
    PTEN hamartoma tumor syndrome (PHTS), DICER1 syndrome, and hereditary leiomyomatosis and renal cell cancer (HLRCC) syndrome are pleiotropic tumor predisposition syndromes that include benign and malignant neoplasms affecting adults and children. PHTS includes several disorders with shared and distinct clinical features. These are associated with elevated lifetime risk of breast, thyroid, endometrial, colorectal, and renal cancers as well as melanoma. Read More

    Study of factors that influence the outcome of (131)I treatment in hyperthyroidism secondary to nodular goitre.
    Rev Esp Med Nucl Imagen Mol 2017 Jun 12. Epub 2017 Jun 12.
    Servicio de Medicina Interna, Hospital POVISA, Vigo, España.
    Objective: To assess the outcome after (131)I treatment in patients with multinodular (MNG) and nodular toxic goitre (NTG) according to the administered dose and other factors related to the patient, pathology, or previous treatments.

    Material And Methods: A retrospective study was conducted on 108 patients (67 MNG and 41 NTG) treated in our department, with a follow-up period of at least 2 years. Development of hypothyroidism and treatment failure were evaluated along with their relationship with the administered dose and other factors such as age, sex, grade of hyperthyroidism, type of goitre, presence of autoimmunity, or previous antithyroid medication. Read More

    Total Thyroidectomy: the first, the best. The recurrent goiter issue.
    Clin Ter 2017 May-Jun;168(3):e194-e198
    Department of Surgery and Medical and Surgical Specialties, General And Breast Surgery Unit, University of Catania.
    Background: Redo surgery for recurrent goiter is still now, even in experienced hands, followed by higher morbidity than primary total thyroidectomy. Suppressive Levothyroxine therapy failed to improve the recurrence rate, while inducing a subclinical hyperthyroidism. Aim of this study is to verify morbidity after total thyroidectomy for benign thyroid diseases, both primary and after recurrence. Read More

    Flavonoids, Thyroid Iodide Uptake and Thyroid Cancer-A Review.
    Int J Mol Sci 2017 Jun 12;18(6). Epub 2017 Jun 12.
    Andrea Claudia Freitas Ferreira, Laboratory of Endocrine Physiology, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, 21941-902 Rio de Janeiro, Brazil.
    Thyroid cancer is the most common malignant tumor of the endocrine system and the incidence has been increasing in recent years. In a great part of the differentiated carcinomas, thyrocytes are capable of uptaking iodide. In these cases, the main therapeutic approach includes thyroidectomy followed by ablative therapy with radioiodine. Read More

    Morbidity of total thyroidectomy for substernal goiter: A series of 70 patients.
    J Visc Surg 2017 Jun 8. Epub 2017 Jun 8.
    Service de chirurgie digestive et viscérale, hôpital Trousseau, avenue de la République, 37170 Chambray-lès-Tours, France.
    Total thyroidectomy for substernal goiter occasionally requires a sternotomy associated with a cervical incision. We sought to analyze the postoperative complications of thyroidectomy for substernal goiters in our center and more precisely the complications related to the sternotomy. All patients who underwent total thyroidectomy for substernal goiter in our center between 2007 and 2016 were reviewed retrospectively. Read More

    A critical review on iodine presence in drinking water access at the Saharawi refugee camps (Tindouf, Algeria).
    J Trace Elem Med Biol 2017 Jul 24;42:32-38. Epub 2017 Mar 24.
    IMDEA Water Institute, Alcalá de Henares 28805, Spain; Department of Electrical Engineering, Universidad de Cádiz, Cádiz 11519, Spain.
    Iodine content in drinking water at the Saharawi refugee camps was analysed to assess the controversy in the origin of the prevalence of goitre among this population. A review on the iodine presence in drinking water reported in the literature was conducted, along with international standards and guidelines for iodine intake and iodine concentration in drinking water were also consulted. Chinese legislation was taken as the reference standard to evaluate the iodine concentration in water as adequate (10-150μg/L) or not (high iodine >150μg/L and iodine excess goitre >300μg/L). Read More

    When Is Thyroidectomy the Right Choice? Comparison between Fine-Needle Aspiration and Final Histology in a Single Institution Experience.
    Eur Thyroid J 2017 Apr 8;6(2):94-100. Epub 2016 Dec 8.
    Pathology Unit, Maria Vittoria Hospital ASL TO2, Turin, Italy.
    Objectives: The aim of this study was to compare SIAPEC-IAP-based cytological reports with their corresponding histological diagnoses to establish when thyroidectomy is the right choice in the management of thyroid diseases.

    Study Design: This is a retrospective review of all the consecutive thyroidectomies/lobectomies performed at Maria Vittoria Hospital during the 10-year period between January 2005 and December 2015. Patients who underwent both fine-needle aspiration (FNA) and surgical procedures in our institution were included in the study. Read More

    A rare case of poorly differentiated thyroid carcinoma probably arising from a nodular goiter.
    BMC Clin Pathol 2017 2;17. Epub 2017 Jun 2.
    Department of Pathology, Osaka Police Hospital, 10-31 Kitayama-cho, Tennouji-ku, Osaka City, Osaka, 543-0035 Japan.
    Background: Some poorly differentiated thyroid carcinomas (PDTC) arise from pre-existing, well-differentiated carcinomas of follicular cell origin; however, others most likely arise de novo. The case of a PDTC adjacent to a pre-existing nodular goiter is very rare.

    Case Presentation: A patient had a PDTC, a widely invasive, cellular tumor with cells that lacked the nuclear features of a papillary thyroid carcinoma. Read More

    Thyroid cancer post radioactive iodine treatment for hyperthyroidism (case series and review of the literature).
    Endokrynol Pol 2017 Jun 6. Epub 2017 Jun 6.
    King Hussein Medical Center Amman-Jordan.
    Introduction: To assess the rate of thyroid cancer and mortality rate in a cohort of patients who received RAI131 treatment for hyperthyroidism and to report the index cases' characteristics and management MATERIAL AND METHODS: A cohort of 264 patients who received RAI131 treatment for different causes of thyrotoxicosis were followed up over a period of 18 years (1996-2014) by physical exam, radiological evaluation and serial thyroid function tests.

    Results: During the follow up period, three cases of thyroid cancer were identified. The prevalence of thyroid cancer is 1. Read More

    Analyses of antioxidant status and nucleotide alterations in genes encoding antioxidant enzymes in patients with benign and malignant thyroid disorders.
    PeerJ 2017 1;5:e3365. Epub 2017 Jun 1.
    Department of Molecular Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.
    Background: Synthesis of thyroid hormones and regulation of their metabolism involve free radicals that may affect redox balance in the body. Thyroid disorders causing variations in the levels of thyroid hormones may alter cellular oxidative stress. The aim of this study was to measure the antioxidant activities and biomarkers of oxidative stress in serum and red blood cells (RBC) of patients with benign and malignant thyroid disorders and to investigate if changes in the antioxidant activities in these patients were linked to alterations in genes encoding the antioxidant enzymes. Read More

    Goitre and urinary iodine in coastal and inland areas with low and high iodized salt coverage in Zhejiang province, China.
    Asia Pac J Clin Nutr 2017 ;26(4):671-679
    Environment and Occupational Health Department, Zhejiang Provincial Center for Disease Prevention and Control, Hangzhou, China. Email:
    Background And Objectives: WHO recommended that iodized salt are more than 90% of households in USI programs, which may not be suitable for all regions, especially in coastal areas. This study intended to find out levels of iodine nutrition and give advice from the USI programs for areas with different iodized salt coverage.

    Methods And Study Design: Coastal and inland areas were selected according to geographical regions in Zhejiang Province, China. Read More

    Insular carcinoma arising on a background of follicular carcinoma, thyrolipomatosis and amyloid goitre.
    BMJ Case Rep 2017 Jun 2;2017. Epub 2017 Jun 2.
    Otolaryngology, Head and Neck Surgery, Royal Darwin Hospital, Darwin, Northern Territory, Australia.
    A 67-year-old man was referred with a history of a right-sided neck lump and dysphonia, secondary to a lesion in the thyroid gland. After undergoing a total thyroidectomy, he was found to have an exceedingly rare combination of follicular carcinoma, insular carcinoma, thyrolipomatosis and an amyloid goitre in his thyroid gland. He subsequently underwent further radioactive iodine ablation and has been in remission. Read More

    Thyrotoxicosis - investigation and management .
    Clin Med (Lond) 2017 Jun;17(3):274-277
    King's College Hospital, Denmark Hill, London
    Graves' disease (GD) and toxic nodular (TN) goitre account for most cases of thyrotoxicosis associated with hyperthyroidism. Hyperthyroidism is confirmed with measurement of a suppressed serum thyrotropin concentration (TSH) and elevated free thyroid hormones. The three therapeutic options are antithyroid drugs, radioactive iodine and surgery. Read More

    Dynamic Changes in the Bivariable Distribution of Urinary Iodine Concentration and Thyroid Volume in Children Aged 8 to 10 Years in China.
    Asia Pac J Public Health 2017 May;29(4):288-295
    1 Harbin Medical University, Harbin, HL, China.
    National iodine-deficiency disorder surveillance surveys were conducted in 1999, 2005, and 2011 in China. Probability-proportional-to-size sampling technique was used to select sampling units. The mean of thyroid volume (Tvol) in the 100 to 199 µg/L UIC (urinary iodine concentration) group was significantly lower than that in the 200 to 299 µg/L UIC group in 2011 ( P < . Read More

    Serum miR-146a, miR-155, and miR-210 as potential markers of Graves' disease.
    J Clin Lab Anal 2017 May 31. Epub 2017 May 31.
    Department of Clinical Laboratory Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
    Background: Previous studies have demonstrated that dysfunctional regulatory T cells (Tregs) may be associated with Graves' disease (GD). In this study, we evaluated four serum Treg-associated miRNAs (miR-210, miR-182, miR-155, and miR-146a) expressions and assessed the potential of serum miRNAs as biomarkers of GD.

    Methods: Foxp3 and serum miRNAs expressions both in GD patients and healthy controls were measured by RT-PCR. Read More

    Pancytopenia and Hypothyroidism in a Patient With Leukemic Infiltration of the Thyroid as the First Presentation of Acute Lymphoblastic Leukemia.
    J Pediatr Hematol Oncol 2017 May 29. Epub 2017 May 29.
    *Division of Pediatric Oncology †Division of Pediatric Endocrinology, Amalia Children's Hospital §Department of Internal Medicine, Division of Endocrinology ∥Department of Pathology ¶Department of Radiology and Nuclear Medicine, Radboud University Medical Center, Nijmegen ‡Department of Pediatric Endocrinology, Academic Medical Center, Emma Children's Hospital, University of Amsterdam, Amsterdam, The Netherlands.
    We report the case of a 16-year-old female patient with hypothyroidism, goiter, and pancytopenia. Biopsy of the thyroid showed leukemic infiltration. After confirmation of the diagnosis of B-lymphoblastic leukemia, treatment was started. Read More

    [PARATHYROID AUTOTRANSPLANTATION IN ADULTS AND CHILDREN].
    Harefuah 2017 Mar(3):167-170
    Department of Surgery, Hillel Yaffe Medical Center, Hadera.
    Introduction: The indications and methods of parathyroid autotransplantation in children and adults are reviewed, with special emphasis on the methods of immediate transplantation and delayed autotransplantation after cryopreservation. Parathyroid autotransplantation is performed during surgery when all four parathyroid glands have been intentionally resected in parathyroid hyperplasia, or when all four glands were inadvertently damaged during total thyroidectomy, or recurrent neck surgery. When parathyroid damage is suspected during thyroid or extensive neck surgery, cryopreservation of a parathyroid gland is performed. Read More

    Medical geology of endemic goiter in Kalutara, Sri Lanka; distribution and possible causes.
    Environ Geochem Health 2017 May 27. Epub 2017 May 27.
    Ofiice of the Dean, Faculty of Applied Sciences, University of Sri Jayewardenepura, Nugegoda, Sri Lanka.
    This study assesses the distribution of goiter in the Kalutara District, Sri Lanka in order to find causative factors for the occurrence of goiter even after the salt iodization. A questionnaire survey was conducted at the household level and at the same time iodine and selenium levels of the water sources were analyzed. Questionnaire survey results indicated the highest numbers of goiter patients in the northern part where the lowest were found in the southern sector which may be due to the presence of acid sulfate soils. Read More

    Case Report of a Massive Retropharyngeal Goiter Resulting in Laryngeal Compression.
    A A Case Rep 2017 May 23. Epub 2017 May 23.
    From the Departments of *Otolaryngology-Head and Neck Surgery and †Anesthesiology, University of Colorado School of Medicine, Aurora, Colorado.
    This is a rare presentation of a morbidly obese male with a massive retropharyngeal goiter causing laryngeal compressive symptoms and unique airway management challenges. Flexible laryngoscopy revealed a retropharyngeal mass circumferentially compressing the oropharynx and supraglottis and preventing the visualization of the glottis. Awake tracheostomy was performed before total thyroidectomy. Read More

    Extrapleural solitary fibrous tumor in thymic area: A case report.
    Medicine (Baltimore) 2017 May;96(21):e6995
    aDepartment of Otolaryngology-Head and Neck Surgery, Chonnam National University Medical School and Chonnam National University Hwasun Hospital bDepartment of Pathology, Chonnam National University Medical School and Chonnam National University Hwasun Hospital, Hwasun, South Korea.
    Rationale: Solitary fibrous tumor (SFT) is a rare benign soft tissue mesenchymal neoplasm. There have been a few reports of extrapleural SFTs although it can occur anywhere in the body.

    Patient Concerns: A 30-year-old male presented with an anterior neck mass since one month. Read More

    Analysis of factors affecting the development of hypocalcaemia after multinodular goitre surgery.
    Pol Przegl Chir 2017 Apr;89(2):26-30
    3 University Reaserch Hospital named after professor Kornel Gibiński of the Medical Univeristy of Silesia in Katowice, Ward of Alimentary Canal Surgery, Ward supervisor prof. Paweł lampe.
    Introduction: Thyroidectomy is a common surgery performed especially in treatment of multinodular goitre. The most common post-thyroidectomy complication is a postoperative hypocalcaemia, and the percentage of postoperative hypoparathyroidism could reach even 50%. Tested group and methods: A forward-looking, randomized testing was done on a group of 113 women being subject to multinodular goitre surgery. Read More

    Primary leiomyosarcoma of thyroid gland: the youngest case.
    Pan Afr Med J 2017 1;26:113. Epub 2017 Mar 1.
    Service d'Oncologie Médicale, Institut Salah Azaiez Tunis, Faculté de Médecine de Tunis, Université el Manar, Tunisie.
    Primary leiomyosarcomas of the thyroid gland are extremely rare. We report a case of a 32 year-old women with a multinodular goiter. She underwent total thyroidectomy. Read More

    Expression of claudin 1, 4 and 7 in thyroid neoplasms.
    Oncol Lett 2017 May 27;13(5):3722-3726. Epub 2017 Mar 27.
    Department of Pathology, University of Health Sciences, Antalya Education and Research Hospital, Antalya 07050, Turkey.
    The distinction of thyroid carcinoma from benign thyroid neoplasm, as well as the subtyping of papillary carcinoma (PC) and follicular carcinoma (FC), may be performed histopathologically in the majority of cases. However, in certain cases, it is difficult to histopathologically distinguish between PC and FC, as well as follicular adenoma (FA), FC and the dominant nodule of multinodular goiter (MNG-DN). The present study aimed to determine the roles of the expression levels of the tight junction proteins claudin 1, 4 and 7 in the differential diagnosis of PC, FC, FA, MNG-DN, medullary carcinoma (MC) and anaplastic carcinoma (AC). Read More

    Myasthenia Gravis, Mediastinal Goiter, and Crohn's Disease.
    Ann Thorac Surg 2017 Jun;103(6):2022
    Hospital Universitário Walter Cantídio Universidade Federal do Ceará, Neurology Division, Rua Capitão Francisco Pedro, 1290, 60430-372 Fortaleza, Ceará, Brazil; Centro Universitário Christus, Campus Parque Ecológico, Fortaleza, Ceará, Brazil. Electronic address:

    Esophageal Cancer Diagnosed by Thyroid Scintigraphy.
    Clin Nucl Med 2017 May 19. Epub 2017 May 19.
    From the Department of Nuclear Medicine, Virgen Macarena University Hospital, Seville, Spain.
    We report a 34-year-old man referred because of increasing dysphagia secondary to goiter. Thyroid scintigraphy and SPECT/CT images helped to recognize an unsuspected esophageal dilation due to a poorly differentiated adenocarcinoma arising at the lower end of the esophagus. Further examinations are mandatory when abnormal activities are observed during thyroid scintigraphy. Read More

    Hashimoto's thyroiditis associated with thyroid adenoma with Hürthle cells - case report.
    Rom J Morphol Embryol 2017 ;58(1):241-248
    Department of Endocrinology, Faculty of Medicine, University of Medicine and Pharmacy of Craiova, Romania;
    Chronic thyroiditis may present a focal lesion, often-palpable abnormality, simulating nodular disease. The number and morphology of the Hürthle cells (HC) vary in the thyroid aspirate. Distinguishing between neoplastic and non-neoplastic HC lesions is difficult when using the fine-needle aspiration cytology (FNAC). Read More

    The Influence of the Manner of Performing the Thyroid Ultrasound Examination on the Reliability of the Assessment of the Thyroid Size in School-Aged Children.
    Horm Res Paediatr 2017 May 18. Epub 2017 May 18.
    Department of Endocrinology and Metabolic Diseases, Medical University of Lodz, Lodz, Poland.
    Background/aims: Goitre incidence in school-aged children evaluated using ultrasonography is one of the essential indicators of iodine intake in a given area. The aim of the study was to examine what the difference is between the volume of the thyroid gland measured in the supine and sitting position and to determine the intra-observer, inter-observer, and inter-position variations.

    Methods: The survey was conducted among 87 children (56 girls and 31 boys aged 7-13 years, mean age 10. Read More

    [The laryngeal condition in the patients presenting with euthyroid multinodular goiter as evaluated by direct laryngoscopy].
    Vestn Otorinolaringol 2017;82(2):38-41
    Aleksandro-Mariinskaya Regional Clinical Hospital, Astrakhan, Russia, 414056.
    The objective of the present study was to improve diagnostics of disturbances in the laryngeal condition of the patients presenting with euthyroid multinodular goiter with special reference to the condition of the upper respiratory passages. The preoperative characteristic of 398 patients included the description of the predominant clinical syndrome (the neoplastic and compressive variants) and specification of the morphological type of the disease to promote the decrease of operative activity with respect to colloidal proliferative goiter. Direct laryngoscopy was employed in addition to the traditional diagnostic techniques during both the surgical operation and the follow-up observation. Read More

    Juvenile nephronophthisis and dysthyroidism: a rare association.
    CEN Case Rep 2017 May 13;6(1):98-104. Epub 2017 Mar 13.
    Shahrak of Gharb (Qods) pathologic and genetic center, Tehran, Iran.
    Nephronophthisis, an autosomal recessive kidney disease, represents the most frequent genetic cause of end-stage kidney disease in the first three decades of life. A 27-year-old male was presented with gait imbalance, sever pruritus since 10 days prior time of admission. In past medical history, he had bilateral cataract, torsional nystagmus, and bilateral optic nerve atrophy since 2 years of age. Read More

    Fetal recurrent thyrotoxicosis.
    Ultrasound Obstet Gynecol 2017 May 15. Epub 2017 May 15.
    Maternal Fetal Medicine Unit. Department of Obstetrics. University Hospital Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain.
    Fetal hyperthyroidism is a rare and potentially life-threatening condition, not always easy to detect(1,2) . It is most commonly observed in maternal thyroid autoimmune disorders such as poorly controlled Grave's disease. Transplacental passage of maternal thyroid stimulating immunoglobulins (TSI) is the main cause of fetal thyroid gland stimulation and the clinical manifestations of this disorder: intrauterine growth restriction, non-immune hydrops, fetal goiter, tachycardia, craniosynostosis, accelerate bone maturation and intrauterine death(2) . Read More

    Radioguided thyroidectomy for follicular tumors: Multicentric experience.
    Int J Surg 2017 May;41 Suppl 1:S75-S81
    VII Unit of Surgery, Department of Surgical, Anesthesiological and Emergency Sciences, Second University of Naples (SUN), Naples, Italy. Electronic address:
    Background: The diagnosis of thyroid nodular diseases requires an integrated approach that has been widely established over the past years. This strategy includes: ultrasonography (US) with; implemented Color-Power-Doppler, conventional scintigraphy also with positive indicators, specific pathological studies targeted by immunohistochemically-assays, and the fine needle; aspiration biopsy (FNAB), which, usually, in case of "Follicular Lesions" (10-20%) findings is; unable to distinguish carcinoma from follicular adenoma, then indicating the necessity of surgery to; obtain a correct diagnosis. The aim of this study was to evaluate the role of the scintigraphy with; positive indicators, both preoperatively in diagnostic approach of the thyroid nodules and; intraoperatively as a guide to the extension of the surgical excision. Read More

    The surgical approach to nodule Thyr 3-4 after the 2.2014 NCCN and 2015 ATA guidelines.
    Int J Surg 2017 May;41 Suppl 1:S21-S25
    Department of Clinical and Experimental Medicine, University Hospital of Parma, Italy. Electronic address:
    Background: The incidence of palpables thyroid nodules in general population is 5% and the prevalence of non -palpable nodules is higher (35-60%) in the endemic goiter area. In the last years the new guidelines and new classification related to thyroid nodule have changed the indication to treat it.

    Material And Method: We analyzed the patients treated from January 2013 to June 2016 for Thyr 3 and Thyr 4 thyroid nodule sec. Read More

    Trends in white blood cell and platelet indices in a comparison of patients with papillary thyroid carcinoma and multinodular goiter do not permit differentiation between the conditions.
    Endocr Res 2017 May 16:1-7. Epub 2017 May 16.
    a Second Department of Propedeutic Surgery , "Laiko" General Hospital, National and Kapodistrian University of Athens, Medical School , Athens , Greece.
    Aim: Carcinogenesis has been related to systematic inflammatory response. Our aim was to study white blood cell and platelet indices as markers of this inflammatory response in thyroid cancer and to associate them with various clinicopathological parameters.

    Methods: We included 228 patients who underwent thyroidectomy within a period of 54 months, 89 with papillary thyroid carcinoma and 139 with multinodular hyperplasia. Read More

    Superior parathyroid gland approach to the recurrent laryngeal nerve.
    Head Neck 2017 Jul 11;39(7):1287-1290. Epub 2017 May 11.
    Department of Otorhinolaryngology - Head and Neck Surgery, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
    Background: The superior parathyroid gland is known to be almost constant in its location under the false thyroid capsule. Could it be a landmark to point to the site of incision of the false thyroid capsule and find the plane of the recurrent laryngeal nerve (RLN) during thyroidectomy?

    Methods: The study included 48 patients with benign goiter scheduled for hemithyroidectomy or total thyroidectomy; there were 16 cases of solitary thyroid nodules, 27 cases of multinodular goiter, and 5 cases of toxic goiter.

    Results: This study included 80 lobectomies. Read More

    Adenoid Cystic Carcinoma of the Larynx Presenting as a Thyroid Mass and Brief Literature Review.
    Acta Cytol 2017 11;61(3):237-241. Epub 2017 May 11.
    Department of Pathology, School of Veterinary Medicine, Shahrekord University, Shahrekord, Iran.
    Background: Adenoid cystic carcinoma (ACC) of the larynx and trachea is very rare.

    Case: A 45-year-old man with ACC of the larynx presenting as a thyroid mass is reported in this study. Physical examination revealed a large solid thyroid nodule in the left lobe without any lymphadenopathy. Read More

    [Implementation of a Vessel Sealing Device in a Centre for Thyroid Surgery: Risk and Economic Profit].
    Zentralbl Chir 2017 May 9. Epub 2017 May 9.
    Chirurgie, Krankenhaus Martha-Maria, Nürnberg, Deutschland.
    Background This study investigated whether the use of the vessel sealing device LigaSure Small Jaw(™) is cost-effective and safe in thyroid surgery despite the high cost of material. Patients and Methods We analysed the results of 224 thyroid operations performed by the same surgeon in three time intervals. We included thyroidectomies and bilateral near-total resections (including Dunhill surgery). Read More

    Diagnostic accuracy of fine needle aspiration cytology in patients undergoing thyroidectomy in Uganda: tertiary hospital experience.
    Afr Health Sci 2016 Dec;16(4):1143-1150
    Department of Pathology, Mulago NationalReferral Hospital.
    Background: Thyroid disease affects about 5% of the World's population. Fine Needle Aspiration Cytology (FNAC) helps in planning extent of surgery. In some studies, FNAC has been found to have a low accuracy for malignancy. Read More

    Defects of Thyroid Hormone Synthesis and Action.
    Endocrinol Metab Clin North Am 2017 Jun 6;46(2):375-388. Epub 2017 Mar 6.
    Department of Medicine, University of Miami Miller School of Medicine, 1120 NW 14th Street, Suite 310F, Miami, FL 33136, USA. Electronic address:
    Congenital hypothyroidism (CH) is the most common inborn endocrine disorder and causes significant morbidity. To date, we are only aware of the molecular basis responsible for the defects in a small portion of patients with CH. A better understanding of the pathophysiology of these cases at the genetic and molecular basis provides useful information for proper counseling to patients and their families a well as for the development of better targeted therapies. Read More

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