6,012 results match your criteria Glucose-6-Phosphate Dehydrogenase Deficiency


Severe Rhabdomyolysis in Glucose-6-Phosphate Dehydrogenase Deficiency.

Am J Med Sci 2020 Apr 2. Epub 2020 Apr 2.

Department of Hematology/Oncology, Saint Joseph University Medical Center, Paterson, New Jersey.

Glucose-6-Phosphate Dehydrogenase (G6PD) deficiency is an X-linked genetic disorder associated with intravascular hemolysis. Rhabdomyolysis with myoglobinuria in a patient with G6PD deficiency is a very rare manifestation, in fact, to the best of our knowledge, only a few case reports have been published in the literature to date. Herein, we report an unusual presentation of a 33-year-old male with G6PD deficiency with multiple episodes of severe rhabdomyolysis with no significant concurrent hemolysis. Read More

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http://dx.doi.org/10.1016/j.amjms.2020.03.018DOI Listing

Adult T-cell leukemia/lymphoma and Glucose-6-phosphate dehydrogenase deficiency rapidly diagnosed through blood smear examination.

Blood Res 2020 May 20. Epub 2020 May 20.

Laboratoire d'hématologie, Centre de Biologie Pathologie, Centre Hospitalier Régional Universitaire de Lille, Lille, France.

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http://dx.doi.org/10.5045/br.2020.2020060DOI Listing

Harm of IV High-Dose Vitamin C Therapy in Adult Patients: A Scoping Review.

Crit Care Med 2020 May 13. Epub 2020 May 13.

Department of Intensive Care, Austin Hospital, Heidelberg, VIC, Australia.

Objectives: The potential harm associated with the use of IV vitamin C has not been systematically assessed. We aimed to review the available evidence on harm related to such treatment.

Data Sources: We searched MEDLINE, EMBASE, Cochrane Library, National Institute of Health Clinical Trials Register, and World Health Organization International Clinical Trials Registry Platform. Read More

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http://dx.doi.org/10.1097/CCM.0000000000004396DOI Listing

Glucose 6 Phosphate Dehydrogenase Deficiency: Description of a novel and de novo variant associated with chronic nonspherocytic hemolytic anemia.

Clin Biochem 2020 May 6. Epub 2020 May 6.

Hospital de Pediatria Dr J P GarraHan, Combate de los Pozos 1881, C1245AAM Ciudad Autonoma de Buenos Air, Argentina. Electronic address:

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http://dx.doi.org/10.1016/j.clinbiochem.2020.04.007DOI Listing

COVID-19 infection and treatment with hydroxychloroquine cause severe haemolysis crisis in a patient with glucose-6-phosphate dehydrogenase deficiency.

Eur J Haematol 2020 Apr 23. Epub 2020 Apr 23.

Haematology Division, Department of Oncology, Geneva University Hospitals, Geneva, Switzerland.

Glucose-6-phosphate dehydrogenase (G6PD) deficiency is an inherited genetic disorder caused by red cell enzymatic defects and is associated with haemolytic crisis when patients are exposed to oxidative agents (fava beans, drugs, infections). Hydroxychloroquine is suspected to trigger haemolytic crisis in G6PD-deficient patients, and off-label administration of this drug to patients infected with the novel coronavirus (SARS-CoV-2) could cause concern. We report here the first case of severe haemolytic crisis in a patient with G6PD deficiency, initiated by severe COVID-19 infection and hydroxychloroquine use. Read More

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http://dx.doi.org/10.1111/ejh.13432DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7264743PMC

Is glucose-6-phosphate dehydrogenase enzyme deficiency a factor in Coronavirus-19 (COVID-19) infections and deaths?

Pathog Glob Health 2020 05 14;114(3):109-110. Epub 2020 Apr 14.

School of Medicine, Koç University, Istanbul, Turkey.

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http://dx.doi.org/10.1080/20477724.2020.1751388DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7241485PMC

G6PD and chloroquine: Selecting the treatment against SARS-CoV-2?

J Cell Mol Med 2020 05 16;24(9):4913-4914. Epub 2020 Apr 16.

Department of Biological Chemistry, Medical School, National and Kapodistrian University of Athens, Athens, Greece.

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http://dx.doi.org/10.1111/jcmm.15312DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7205832PMC

Cystine transporter regulation of pentose phosphate pathway dependency and disulfide stress exposes a targetable metabolic vulnerability in cancer.

Nat Cell Biol 2020 04 30;22(4):476-486. Epub 2020 Mar 30.

Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

SLC7A11-mediated cystine uptake is critical for maintaining redox balance and cell survival. Here we show that this comes at a significant cost for cancer cells with high levels of SLC7A11. Actively importing cystine is potentially toxic due to its low solubility, forcing cancer cells with high levels of SLC7A11 (SLC7A11) to constitutively reduce cystine to the more soluble cysteine. Read More

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http://dx.doi.org/10.1038/s41556-020-0496-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7194135PMC
April 2020
19.679 Impact Factor

The prevalence of glucose-6-phosphate dehydrogenase deficiency in the Cape Verdean population in the context of malaria elimination.

PLoS One 2020 16;15(3):e0229574. Epub 2020 Mar 16.

Laboratoire d'Ecologie Vectorielle et Parasitaire, Faculté des Sciences et Techniques, Université Cheikh Anta Diop (UCAD) de Dakar, Dakar, Sénégal.

Cabo Verde aims to eliminate malaria by 2020. In the country, Plasmodium falciparum had been the main parasite responsible for indigenous cases and primaquine is the first line treatment of cases and for radical cure. However, the lack of knowledge of the national prevalence of glucose-6-phosphate dehydrogenase (G6PD) deficiency may be one of the constraints to the malaria elimination process. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0229574PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7075545PMC

Hypoxic activation of glucose-6-phosphate dehydrogenase controls the expression of genes involved in the pathogenesis of pulmonary hypertension through the regulation of DNA methylation.

Am J Physiol Lung Cell Mol Physiol 2020 Apr 11;318(4):L773-L786. Epub 2020 Mar 11.

Department of Pharmacology, New York Medical College, Valhalla, New York.

Metabolic reprogramming is considered important in the pathogenesis of the occlusive vasculopathy observed in pulmonary hypertension (PH). However, the mechanisms that link reprogrammed metabolism to aberrant expression of genes, which modulate functional phenotypes of cells in PH, remain enigmatic. Herein, we demonstrate that, in mice, hypoxia-induced PH was prevented by glucose-6-phosphate dehydrogenase deficiency (G6PD), and further show that established severe PH in mice was attenuated by knockdown with G6PD shRNA or by G6PD inhibition with an inhibitor (N-ethyl-N'-[(3β,5α)-17-oxoandrostan-3-yl]urea, NEOU). Read More

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http://dx.doi.org/10.1152/ajplung.00001.2020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7191486PMC
April 2020
4.080 Impact Factor

[Hemoglobinuria in children hospitalized in Ouagadougou: short term inpatient care and prognosis].

Pan Afr Med J 2019 26;34:165. Epub 2019 Nov 26.

Service de Pédiatrie Médicale, Centre Hospitalier Universitaire Pédiatrique Charles-de-Gaulle, Ouagadougou, Burkina Faso.

Introduction: The purpose of this study was to analyze the epidemiological, diagnostic, therapeutic and evolutionary features of hemoglobinuria in children hospitalized in the Pediatric University Hospital Charles de Gaulle, Ouagadougou.

Methods: We conducted a cross-sectional descriptive study over the period 01 July-31 December 2014. All children aged 0-15 years hospitalized in the Department of Medical Pediatrics of the Pediatric University Hospital Charles de Gaulle and diagnosed with macroscopic hemoglobinuria during the study period were enrolled. Read More

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http://dx.doi.org/10.11604/pamj.2019.34.165.14729DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7046116PMC

Factors associated with anaemia in a nationally representative sample of nonpregnant women of reproductive age in Nepal.

Matern Child Nutr 2020 Mar 10:e12953. Epub 2020 Mar 10.

Nutrition Branch, Division of Nutrition, Physical Activity, and Obesity, United States Centers for Disease Control and Prevention, Atlanta, Georgia, USA.

We used cross-sectional data from the 2016 Nepal National Micronutrient Status Survey to evaluate factors associated with anaemia among a nationally representative sample of nonpregnant women 15- 49 years (n = 1, 918). Haemoglobin, biomarkers of iron status and other micronutrients, infection, inflammation, and blood disorders were assessed from venous blood. Soil-transmitted helminth and Helicobacter pylori infections were assessed from stool. Read More

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http://dx.doi.org/10.1111/mcn.12953DOI Listing

Evaluation of glucose-6-phosphate dehydrogenase serum level in patients with multiple sclerosis and neuromyelitis optica.

Iran J Neurol 2019 Oct;18(4):150-153

Isfahan Neurosciences Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.

Multiple sclerosis (MS) and neuromyelitis optica (NMO) are both demyelinating disorders and oxidative stress is suggested to have a role in their pathogenesis. Glucose-6-phosphate dehydrogenase (G6PD) produces nicotinamide adenine dinucleotide phosphate (NADPH) via the pentose phosphate pathway. NADPH is not only involved in the synthesis of fatty acids necessary for myelination, but also it is involved in the defense against oxidative stress. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7036045PMC
October 2019

Prevalence of and mothers' knowledge, attitude and practice towards glucose-6-phosphate dehydrogenase deficiency among neonates with jaundice: a cross-sectional study.

BMJ Open 2020 Feb 25;10(2):e034079. Epub 2020 Feb 25.

Family medicine department, Menoufia faculty of medicine, Shebin El-Kom, Menoufia, Egypt.

Background: Neonatal jaundice (NNJ) is a frequent complication of glucose-6-phosphate dehydrogenase (G6PD) deficiency.

Objectives: To estimate the prevalence of G6PD deficiency among neonates with jaundice and to assess mothers' perception towards G6PD and NNJ.

Methods: A cross-sectional study was carried out on 487 ethnic Egyptian neonates with indirect hyperbilirubinaemia from June 2018 to July 2019. Read More

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http://dx.doi.org/10.1136/bmjopen-2019-034079DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7045182PMC
February 2020

Associations among Soil-Transmitted Helminths, G6PD Deficiency and Asymptomatic Malaria Parasitemia, and Anemia in Schoolchildren from a Conflict Zone of Northeast Myanmar.

Am J Trop Med Hyg 2020 Apr;102(4):851-856

Department of Pathogen Biology and Immunology, Kunming Medical University, Kunming, China.

In tropical areas of developing countries, the interactions among parasitic diseases such as soil-transmitted helminths (STHs) and malaria, and glucose-6-phosphate dehydrogenase deficiency (G6PDd), are complex. Here, we investigated their interactions and impact on anemia in school students residing in a conflict zone of northeast Myanmar. A cross-sectional survey was conducted between July and December 2015 in two schools located along the China-Myanmar border. Read More

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http://dx.doi.org/10.4269/ajtmh.19-0828DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7124928PMC

Evaluation of the Diagnostic Accuracy of the CareStart™ Glucose-6-Phosphate Dehydrogenase Deficiency Rapid Diagnostic Test among Chinese Newborns.

J Trop Pediatr 2020 Feb 10. Epub 2020 Feb 10.

Department of Clinical and Research Center of Infectious Disease, Beijing Ditan Hospital, Capital Medical University, Beijing, China.

Previous studies have shown that the CareStart™ G6PD Deficiency rapid diagnostic test has high diagnostic accuracy on G6PD deficiency in Africa and Thailand, but not in China. As there are regional differences of G6PD genotype distribution, we are attending to verify the effectiveness of the kit in Chinese population. The study cohort included 247 newborns admitted to our hospital for jaundice. Read More

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http://dx.doi.org/10.1093/tropej/fmaa003DOI Listing
February 2020

Evaluation of the CareStart™ glucose-6-phosphate dehydrogenase (G6PD) rapid diagnostic test in the field settings and assessment of perceived risk from primaquine at the community level in Cambodia.

PLoS One 2020 31;15(1):e0228207. Epub 2020 Jan 31.

Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand.

Background: Primaquine is an approved radical cure treatment for Plasmodium vivax malaria but treatment can result in life-threatening hemolysis if given to a glucose-6-phosphate dehydrogenase deficient (G6PDd) patient. There is a need for reliable point-of-care G6PD diagnostic tests.

Objectives: To evaluate the performance of the CareStart™ rapid diagnostic test (RDT) in the hands of healthcare workers (HCWs) and village malaria workers (VMWs) in field settings, and to better understand user perceptions about the risks and benefits of PQ treatment guided by RDT results. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0228207PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6994100PMC

Newborn Screening for Congenital Hypothyroidism, Congenital Adrenal Hyperplasia, and Glucose-6-Phosphate Dehydrogenase Deficiency for Improving Health Care in India.

J Pediatr Intensive Care 2020 Mar 14;9(1):40-44. Epub 2019 Oct 14.

Institute of Medical Genetics & Genomics, Sir Ganga Ram Hospital, New Delhi, India.

Newborn screening (NBS) aims toward early detection of treatable congenital disorders. From January 2008 through December 2017, 13,376 newborns were screened for congenital hypothyroidism (CH), congenital adrenal hyperplasia (CAH), and glucose-6-phosphate dehydrogenase (G6PD) deficiency at Sir Ganga Ram Hospital, India, by measuring G6PD activity, thyroid-stimulating hormone, and 17-hydroxyprogesterone on dried blood specimens. The birth prevalence of 1:2,000 for CH, 1:2,500 for CAH, and 1:125 for G6PD deficiency indicates the latter as the most prevalent. Read More

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http://dx.doi.org/10.1055/s-0039-1698424DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6978160PMC

Donor glucose-6-phosphate dehydrogenase deficiency decreases blood quality for transfusion.

J Clin Invest 2020 May;130(5):2270-2285

Department of Pathology and Cell Biology, Columbia University Vagelos College of Physicians and Surgeons and NewYork-Presbyterian Hospital, New York, New York, USA.

BACKGROUNDGlucose-6-phosphate dehydrogenase (G6PD) deficiency decreases the ability of red blood cells (RBCs) to withstand oxidative stress. Refrigerated storage of RBCs induces oxidative stress. We hypothesized that G6PD-deficient donor RBCs would have inferior storage quality for transfusion as compared with G6PD-normal RBCs. Read More

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http://dx.doi.org/10.1172/JCI133530DOI Listing

Associations between red blood cell variants and malaria among children and adults from three areas of Uganda: a prospective cohort study.

Malar J 2020 Jan 15;19(1):21. Epub 2020 Jan 15.

Department of Medicine, University of California, San Francisco, CA, 94110, USA.

Background: Multiple red blood cell (RBC) variants appear to offer protection against the most severe forms of Plasmodium falciparum malaria. Associations between these variants and uncomplicated malaria are less clear.

Methods: Data from a longitudinal cohort study conducted in 3 sub-counties in Uganda was used to quantify associations between three red blood cell variants Hb [AA, AS, S (rs334)], alpha thalassaemia 3. Read More

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http://dx.doi.org/10.1186/s12936-020-3105-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6964006PMC
January 2020

Severe Methemoglobinemia Secondary to Ingestion in an Infant: A Case Report.

Saudi J Med Med Sci 2020 Jan-Apr;8(1):56-59. Epub 2019 Dec 23.

Department of Pediatrics, Abha Maternity and Children Hospital, Abha, Kingdom of Saudi Arabia.

Methemoglobinemia is an increase in the methemoglobin levels in the blood. Infants are more susceptible to develop secondary methemoglobinemia because of the limited activity of methemoglobin reductase B enzyme. We report a case of life-threatening methemoglobinemia secondary to ingestion of herbal remedy in an infant who presented with cyanosis and severe respiratory distress. Read More

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http://dx.doi.org/10.4103/sjmms.sjmms_5_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6945318PMC
December 2019

A bolt from the blue; A case report of an unusual asthma exacerbation.

Respir Med Case Rep 2020 12;29:100983. Epub 2019 Dec 12.

Department of Respiratory Medicine, Cork University Hospital, Wilton, Cork, Ireland.

Background: We describe this case of a young gentleman presenting with acute dyspnoea on a background history of known, long-standing asthma. His dramatic presentation, notable for profound hypoxia and cyanosis, led to an unexpected additional diagnosis of type one congenital methaemoglobinaemia.

Case Presentation: A 26-year-old Irish gentleman was transferred urgently to the emergency department resuscitation room with marked cyanosis and tachypnoea. Read More

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http://dx.doi.org/10.1016/j.rmcr.2019.100983DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6938945PMC
December 2019

[GENETIC ASPECTS OF RESISTANCE TO MALARIA (REVIEW)].

Georgian Med News 2019 Nov(296):66-70

Sechenov First Moscow State Medical University, Russia.

Malaria is one of the most important and common infectious diseases in the world. The world health organization estimates 225 million malaria cases worldwide. Malaria is one of the strongest selective factors affecting the human genotype. Read More

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November 2019

Age, Ethnicity, Glucose-6-Phosphate Dehydrogenase Deficiency, Micronutrient Powder Intake, and Biomarkers of Micronutrient Status, Infection, and Inflammation Are Associated with Anemia Among Children 6-59 Months in Nepal.

J Nutr 2020 Apr;150(4):929-937

Nutrition Branch, Division of Nutrition, Physical Activity, and Obesity, United States Centers for Disease Control and Prevention, 4770 Buford Hwy NW, Atlanta, GA, 30341, USA.

Background: Anemia is a major concern for children in Nepal; however, little is known about context-specific causes of anemia.

Objective: We used cross-sectional data from the 2016 Nepal National Micronutrient Status Survey to evaluate factors associated with anemia in a nationally representative, population-based sample of children 6-59 mo (n = 1367).

Methods: Hemoglobin, biomarkers of iron status and other micronutrients, infection, inflammation, and blood disorders were assessed from venous blood samples. Read More

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http://dx.doi.org/10.1093/jn/nxz307DOI Listing

Evaluation of quantitative biosensor for glucose-6-phosphate dehydrogenase activity detection.

PLoS One 2019 20;14(12):e0226927. Epub 2019 Dec 20.

Department of Medical Technology, Faculty of Allied Health Sciences, Thammasat University, Pathumtani, Thailand.

Neonatal jaundice is a common and severe disease in premature infants with Glucose-6-Phosphate Dehydrogenase (G-6-PD) deficiency. The World Health Organization (WHO) has recommended screening for G-6-PD deficiency in newborns for early recognition as well as to prevent unwanted outcomes in a timely manner. The present study aimed to assess a point-of-care, careSTARTTM G6PD biosensor as a quantitative method for the diagnosis of G-6-PD deficiency. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0226927PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6924682PMC

Prevalence of glucose-6-phosphate dehydrogenase deficiency, U.S. Armed Forces, May 2004-September 2018.

MSMR 2019 Dec;26(12):14-17

Glucose-6-phosphate dehydrogenase (G6PD) deficiency is an inherited genetic disorder most commonly associated with hemolytic anemia. Among those with G6PD deficiency, hemolytic anemia may be triggered by bacterial or viral infections and by certain foods and drugs, including the 8-aminoquinoline (8-AQ) class of antimalarials. Because 8-AQ drugs remain the only drugs approved by the U. Read More

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December 2019

Performance of the Access Bio/CareStart rapid diagnostic test for the detection of glucose-6-phosphate dehydrogenase deficiency: A systematic review and meta-analysis.

PLoS Med 2019 12 13;16(12):e1002992. Epub 2019 Dec 13.

Global and Tropical Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, Australia.

Background: To reduce the risk of drug-induced haemolysis, all patients should be tested for glucose-6-phosphate dehydrogenase (G6PD) deficiency (G6PDd) prior to prescribing primaquine (PQ)-based radical cure for the treatment of vivax malaria. This systematic review and individual patient meta-analysis assessed the utility of a qualitative lateral flow assay from Access Bio/CareStart (Somerset, NJ) (CareStart Screening test for G6PD deficiency) for the diagnosis of G6PDd compared to the gold standard spectrophotometry (International Prospective Register of Systematic Reviews [PROSPERO]: CRD42019110994).

Methods And Findings: Articles published on PubMed between 1 January 2011 and 27 September 2019 were screened. Read More

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http://dx.doi.org/10.1371/journal.pmed.1002992DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6910667PMC
December 2019

Case reports of metabolic disorders from Nepal.

Mol Genet Metab Rep 2019 Dec 19;21:100542. Epub 2019 Nov 19.

Department of Biochemistry, Kathmandu Medical College (Basic Sciences), Duwakot, Bhaktapur, Nepal.

Background: The prevalence of metabolic disease in Nepal is largely unknown. Some consideration has been given by the nepalese government for high prevalence of congenital disorders in some populations, but disorders due to enzymatic deficiencies have not been considered as a class of diseases where timely diagnosis and intervention might be possible. No case for these disorders has been made so far, however, findings of many rare metabolic diseases have been reported in literature by the nepalese medical fraternity. Read More

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http://dx.doi.org/10.1016/j.ymgmr.2019.100542DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6880005PMC
December 2019

Paroxysmal Nocturnal Hemoglobinuria with Glucose-6-Phosphate Dehydrogenase Deficiency: A Case Report and Review of the Literature.

Case Rep Oncol 2019 Sep-Dec;12(3):838-844. Epub 2019 Nov 1.

Hematology Department, National Center for Cancer Care and Research, Hamad Medical Corporation, Doha, Qatar.

In this study, we are describing a female patient with paroxysmal nocturnal hemoglobinuria (PNH) and glucose-6-phosphate dehydrogenase (G6PD) deficiency. Both diseases are known to cause hemolytic anemia that mediates the hemolysis of RBCs through several mechanisms. In PNH the hemolysis is mediated through complement activation and oxidative stress. Read More

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http://dx.doi.org/10.1159/000503817DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6873095PMC
November 2019

Role of high-volume plasma exchange in a case of a G6PD deficient patient presenting with HAV related acute liver failure and concomitant acute renal failure.

Transfus Apher Sci 2019 Dec 7;58(6):102677. Epub 2019 Nov 7.

Department of Transfusion Medicine, Institute of Liver and Biliary Sciences, New Delhi, India. Electronic address:

A mild degree of hemolysis is commonly encountered complication in acute viral hepatitis patients which generally resolves as the disease recovers. Rarely, some patients might present with severe hemolysis associated with glucose-6-phosphate dehydrogenase (G6PD) deficiency. It has been hypothesized that the hemolysis is initially provoked by the viral infection itself; however, it may be aggravated due to the administration of certain drugs in patients with G6PD deficiency. Read More

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http://dx.doi.org/10.1016/j.transci.2019.102677DOI Listing
December 2019

Severe neonatal hyperbilirubinemia in the southeast region of Turkey

Turk J Med Sci 2020 02 13;50(1):103-109. Epub 2020 Feb 13.

General Pediatrics Unit, Şanlıurfa Training and Research Hospital, Şanlıurfa, Turkey

Background/aim: Severe neonatal hyperbilirubinemia is an important cause of morbidity and mortality in developing countries. The aim was to assess etiologic reasons for development of severe hyperbilirubinemia and define risk factors for exchange transfusion and acute bilirubin encephalopathy (ABE) in Şanlıurfa located in the southeast region of Turkey.

Materials And Methods: An observational cohort study included 115 infants with ≥35 weeks of gestation admitted with diagnosis of severe hyperbilirubinemia in a period of 18 months. Read More

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http://dx.doi.org/10.3906/sag-1906-22DOI Listing
February 2020

Probable blueberry-induced haemolysis in a G6PD deficient child: A case report.

Nutr Health 2019 Dec 11;25(4):303-305. Epub 2019 Nov 11.

Department of Paediatrics, JSS Medical College and Hospital, JSS Academy of Higher Education & Research, Mysore, Karnataka, India.

Background: Blueberry is a North American native fruit increasingly popular as a source of health-promoting bioactive compounds. However, there is evidence in the literature stating that blueberries should be avoided in individuals with glucose-6-phosphate dehydrogenase (G6PD) deficiency.

Case Presentation: We report the first case of a G6PD deficient child who developed haemolysis approximately after half a day following the intake of fresh blueberry. Read More

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http://dx.doi.org/10.1177/0260106019885290DOI Listing
December 2019

Glucose 6 phosphate dehydrogenase deficiency and hemoglobinopathy in South Western Region Nepal: a boon or burden.

BMC Res Notes 2019 Nov 8;12(1):734. Epub 2019 Nov 8.

Department of Pharmacological and Bio-Molecular Sciences, Universita Degli Studi Di Milano, Milan, Italy.

Objectives: The study was carried out to optimize the phenotypic method to characterize the sickle cell trait (SCT), sickle cell anemia (SCA), and β-thalassemia (β-TT) suspected sample from tharu community of South Western province-5, Nepal. SCT and SCA were further evaluated by genotypic method employing amplification refractory mutation system (ARMS PCR). Moreover, Glucose 6 phosphate dehydrogenase (G6PD) was estimated in those hemoglobinopathy to observe its prevalence. Read More

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http://dx.doi.org/10.1186/s13104-019-4762-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6839259PMC
November 2019

Case Report: A Case of Primaquine-Induced Hemoglobinuria in Glucose-6-Phosphate Dehydrogenase Deficient Malaria Patient in Southeastern Bangladesh.

Am J Trop Med Hyg 2020 01;102(1):156-158

International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka, Bangladesh.

We herein report the first case of Mediterranean glucose-6-phosphate dehydrogenase (G6PD) variant from Bangladesh. A boy had been admitted to hospital and was diagnosed with uncomplicated infection and treated with 30 mg/kg body weight (BW) chloroquine for 3 days and 4.8 mg/kg BW primaquine (PQ) to be taken over 14 days. Read More

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http://dx.doi.org/10.4269/ajtmh.19-0643DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6947770PMC
January 2020

A typical presentation of dengue fever in a G6PD deficient patient: A case report.

J Pak Med Assoc 2019 Oct;69(10):1553-1556

Northwest General Hospital, Peshawar, Pakistan.

Dengue is a mosquito-borne viral disease that has rapidly spread in the recent years, particularly in South Asia. While haematologic complications, such as cytopenia and bleeding, may occur in severe dengue infection, reports of haemolytic anaemia in dengue fever are scant. We report a patient who developed haemolytic anaemia following dengue fever. Read More

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October 2019
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Metabolic Insight of Neutrophils in Health and Disease.

Front Immunol 2019 20;10:2099. Epub 2019 Sep 20.

Translational Health Science and Technology Institute, Faridabad, India.

Neutrophils are the most abundant, short lived, and terminally differentiated leukocytes with distinct tiers of arsenals to counter pathogens. Neutrophils were traditionally considered transcriptionally inactive cells, but recent researches in the field led to a paradigm shift in neutrophil biology and revealed subpopulation heterogeneity, and functions pivotal to immunity and inflammation. Furthermore, recent unfolding of metabolic plasticity in neutrophils has challenged the long-standing concept of their sole dependence on glycolytic pathway. Read More

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http://dx.doi.org/10.3389/fimmu.2019.02099DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6764236PMC
September 2019
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G6PD deficiency: An update.

JAAPA 2019 Nov;32(11):21-26

Susan J. Harcke is a PA and medical officer in the Delaware National Guard's 31st Civil Support Team in Smyrna, Del. Denise Rizzolo is an assistant clinical professor at the Pace Completion Program in the Department of Physician Studies in New York City and an assessment specialist for the Physician Assistant Education Association. H. Theodore Harcke is a professor of radiology and pediatrics at Sidney Kimmel College of Medicine, Thomas Jefferson University, in Philadelphia, Pa. The authors have disclosed no potential conflicts of interest, financial or otherwise.

Although glucose-6-phosphate dehydrogenase (G6PD) deficiency is less known in Western countries than in the Middle East and Africa, global migration and immigration are bringing ethnic groups with the highest incidence of this inherited genetic disorder into the US healthcare system. The G6PD enzyme is critical to protecting erythrocytes against oxidative stress, and deficiency may lead to hemolysis in the presence of certain environmental factors such as infection and some medications and foods. Neonatal jaundice, favism, and hemolysis are associated with exposure to increased oxidative stressors in patients with G6PD deficiency. Read More

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http://dx.doi.org/10.1097/01.JAA.0000586304.65429.a7DOI Listing
November 2019

Management of Athletes With G6PD Deficiency: Does Missing an Enzyme Mean Missing More Games?

Sports Health 2020 Mar/Apr;12(2):149-153. Epub 2019 Oct 11.

Primary Care Sports Medicine Fellowship, Department of Family & Community Medicine, Wake Forest School of Medicine, Medical Center Boulevard, Winston-Salem, North Carolina.

Context: Glucose-6-phosphate dehydrogenase (G6PD) deficiency is likely the most prevalent enzyme deficiency on the planet, with an estimated 4.9% of people, or approximately 330 million individuals, across the globe affected by the disease. In the United States, 4% to 7% of the population is likely affected, but each year our nation's major sport leagues become more international. Read More

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http://dx.doi.org/10.1177/1941738119877177DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7040941PMC
March 2020
3 Reads

Prevalence and distribution of G6PD deficiency: implication for the use of primaquine in malaria treatment in Ethiopia.

Malar J 2019 Oct 7;18(1):340. Epub 2019 Oct 7.

Program in Public Health, College of Health Sciences, University of California, Irvine, CA, 92697, USA.

Background: G6PD enzyme deficiency is a common enzymatic X-linked disorder. Deficiency of the G6PD enzyme can cause free radical-mediated oxidative damage to red blood cells, leading to premature haemolysis. Treatment of Plasmodium vivax malaria with primaquine poses a potential risk of mild to severe acute haemolytic anaemia in G6PD deficient people. Read More

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http://dx.doi.org/10.1186/s12936-019-2981-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6781416PMC
October 2019
2 Reads
3.109 Impact Factor

Severe inflammatory reaction following corneal collagen cross-linking in a patient with glucose-6-phosphate dehydrogenase deficiency.

Can J Ophthalmol 2019 10 23;54(5):e234-e237. Epub 2019 Jan 23.

Centre Hospitalier de l'Université de Montréal, Montreal, Que.

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http://dx.doi.org/10.1016/j.jcjo.2018.12.006DOI Listing
October 2019
5 Reads

Inhibition effects of some antidepressant drugs on pentose phosphate pathway enzymes.

Environ Toxicol Pharmacol 2019 Nov 16;72:103244. Epub 2019 Aug 16.

Department of Chemistry, Faculty of Science, Atatürk University, 25240, Erzurum, Turkey.

The glucose metabolism in the pentose cycle is essential to the source of NADPH. Deficiency of these enzymes have been linked to depression and psychotic disorders. Depression is an increasingly prevalent mental disorder which may cause loss of labor. Read More

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http://dx.doi.org/10.1016/j.etap.2019.103244DOI Listing
November 2019
3 Reads

Hemolytic Dynamics of Weekly Primaquine Antirelapse Therapy Among Cambodians With Acute Plasmodium vivax Malaria With or Without Glucose-6-Phosphate Dehydrogenase Deficiency.

J Infect Dis 2019 10;220(11):1750-1760

Centre for Tropical Medicine, Nuffield Department of Medicine, University of Oxford, United Kingdom.

Background: Hemoglobin (Hb) data are limited in Southeast Asian glucose-6-phosphate dehydrogenase (G6PD) deficient (G6PD-) patients treated weekly with the World Health Organization-recommended primaquine regimen (ie, 0.75 mg/kg/week for 8 weeks [PQ 0.75]). Read More

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http://dx.doi.org/10.1093/infdis/jiz313DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6804333PMC
October 2019
4 Reads

Hemoglobin S and Glucose-6-Phosphate Dehydrogenase Deficiency Coinheritance in AS and SS Individuals in Malaria-Endemic Region: A Study in Calabar, Nigeria.

J Glob Infect Dis 2019 Jul-Sep;11(3):118-122

Department of Medical Laboratory Science, Hematology Unit, College of Medical Sciences, University of Calabar, Calabar, Nigeria.

Background: Malaria placed a huge burden on human life and has been reported to be a key health problem affecting developing countries. This study was designed to assay for glucose-6-phosphate dehydrogenase (G6PD) status and malaria parasite density of individuals with sickle cell gene in University of Calabar Teaching Hospital, Calabar.

Subjects And Methods: The methemoglobin method was used to determine the G6PD status. Read More

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http://dx.doi.org/10.4103/jgid.jgid_154_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6733195PMC
September 2019
2 Reads

Assessment of glucose-6-phosphate dehydrogenase activity using CareStart G6PD rapid diagnostic test and associated genetic variants in Plasmodium vivax malaria endemic setting in Mauritania.

PLoS One 2019 16;14(9):e0220977. Epub 2019 Sep 16.

Unité de recherche Génomes et Milieux, Faculté des Sciences et Techniques, Université de Nouakchott Al-Aasriya, Nouveau Campus Universitaire, Nouakchott, Mauritania.

Background: Primaquine is recommended by the World Health Organization (WHO) for radical treatment of Plasmodium vivax malaria. This drug is known to provoke acute hemolytic anemia in individuals with glucose-6-phosphate dehydrogenase (G6PD) deficiency. Due to lack of data on G6PD deficiency, the use of primaquine has been limited in Africa. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0220977PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6746352PMC
March 2020
2 Reads

Caution is Needed in Interpreting Hemoglobin A1c Levels in the Muslim Bedouin Population of Southern Israel.

Isr Med Assoc J 2019 Aug;21(8):546-551

Department of Family Medicine and Siaal Research Center for Family Practice and Primary Care, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheva, Israel.

Background: The Bedouins living in southern Israel are a Muslim-Arab population that is transitioning from a nomadic lifestyle to life in permanent settlements. The population has unique characteristics that could affect hemoglobin A1c (HbA1c) measurements. The objective of this study was to describe the socio-demographic and unique morbidity characteristics of this community and their effect on HbA1c measurements. Read More

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August 2019
2 Reads

[Complicated viral to cholestatic hepatitis in a child with glucose-6-phosphate dehydrogenase deficiency from a high andean region].

Rev Peru Med Exp Salud Publica 2019 Apr-Jun;36(2):366-368. Epub 2019 Aug 22.

Servicio de Pediatría del Hospital II Huamanga de ESSALUD. Huamanga, Ayacucho.

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http://dx.doi.org/10.17843/rpmesp.2019.362.4075DOI Listing