5,893 results match your criteria Glucose-6-Phosphate Dehydrogenase Deficiency


Metabolic reprogramming and redox adaptation in sorafenib-resistant leukemia cells: detected by untargeted metabolomics and stable isotope tracing analysis.

Cancer Commun (Lond) 2019 Apr 4;39(1):17. Epub 2019 Apr 4.

Department of Experimental Therapeutics, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, 651 Dong Feng East Road, Guangzhou, 510060, Guangdong, P. R. China.

Background: Internal tandem duplications (ITD) within the juxtamembrane domain of FMS-like tyrosine kinase 3 (FLT3) represent a poor prognostic indicator in acute myeloid leukemia (AML). Therapeutic benefits of tyrosine kinase inhibitors, such as sorafenib, are limited due to the emergence of drug resistance. While investigations have been conducted to improve the understanding of the molecular mechanisms underlying the resistance to this FLT3 inhibitor, a profile of cell functioning at the metabolite level and crosstalk between metabolic pathways has yet to be created. Read More

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http://dx.doi.org/10.1186/s40880-019-0362-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449955PMC
April 2019
3 Reads

Prevalence of glucose-6-phosphate dehydrogenase deficiency in Cameroonian blood donors.

BMC Res Notes 2019 Apr 2;12(1):195. Epub 2019 Apr 2.

Division of Global Pediatrics, Department of Pediatrics, University of Minnesota, Minneapolis, MN, USA.

Objective: Deficiency in G6PD is the most common enzymopathy worldwide. It is frequently found in individuals of African descent in whom it can lead to hemolytic crises triggered by the use of certain antimalarial medications and infection. The prevalence of G6PD deficiency and its contribution to morbidity in West Africa is under-studied. Read More

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http://dx.doi.org/10.1186/s13104-019-4226-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444568PMC
April 2019
2 Reads

50 Years Ago in The Journal of Pediatrics: The Hemolytic Crisis of Sickle Cell Disease: The Role of Glucose-6-Phosphate Dehydrogenase Deficiency.

J Pediatr 2019 Apr;207:204

Department of Pediatrics Tuba City Regional Health Care Corporation Tuba City, Arizona.

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http://dx.doi.org/10.1016/j.jpeds.2018.10.032DOI Listing
April 2019
1 Read

Treatment of a patient with breast cancer and glucose 6-phosphate dehydrogenase deficiency: A case report.

Medicine (Baltimore) 2019 Mar;98(13):e14987

Department of Surgery, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.

Rationale: Glucose 6-phosphate dehydrogenase (G6PD) deficiency is the most common enzymatic disorder of red blood cells that cause hemolytic anemia. Some anticancer drugs are reported to trigger oxidative stress; however, events of hemolysis are rarely discussed in patients with G6PD deficiency required oncologic treatments.

Patient Concerns: Here we reported a young woman with G6PD deficiency safely undergoing breast cancer treatment. Read More

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http://dx.doi.org/10.1097/MD.0000000000014987DOI Listing
March 2019
1 Read

Glucose-6-phosphate dehydrogenase deficiency allelic variants and their prevalence in malaria patients in Eritrea.

Pan Afr Med J 2018 20;31:46. Epub 2018 Sep 20.

Eritrea Institute of Technology, Asmara, Eritrea.

Introduction: Glucose 6-phosphate dehydrogenase (G6PD) deficiency is the most common enzymopathy with a relatively high frequency in malaria-endemic regions. In Eritrea, there is scanty knowledge of G6PD deficiency. The aim of the study was to characterize and determine the prevalence of four common G6PD allelic variants. Read More

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http://dx.doi.org/10.11604/pamj.2018.31.46.16527DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6430948PMC
April 2019
1 Read

Evaluation of Prospective HLA-B*13:01 Screening to Prevent Dapsone Hypersensitivity Syndrome in Patients With Leprosy.

JAMA Dermatol 2019 Mar 27. Epub 2019 Mar 27.

Hainan Provincial Center for Skin Disease and STI Control, Haikou, Hainan.

Importance: Dapsone hypersensitivity syndrome (DHS) is the most serious adverse reaction associated with dapsone administration and one of the major causes of death in patients with leprosy, whose standard treatment includes multidrug therapy (MDT) with dapsone, rifampicin, and clofazimine. Although the HLA-B*13:01 polymorphism has been identified as the genetic determinant of DHS in the Chinese population, no studies to date have been done to evaluate whether prospective HLA-B*13:01 screening could prevent DHS by identifying patients who should not receive dapsone.

Objective: To evaluate the clinical use of prospective HLA-B*13:01 screening for reduction of the incidence of DHS by excluding dapsone from the treatment for patients with HLA-B*13:01-positive leprosy. Read More

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http://dx.doi.org/10.1001/jamadermatol.2018.5360DOI Listing
March 2019
1 Read

The tolerability of single low dose primaquine in glucose-6-phosphate deficient and normal falciparum-infected Cambodians.

BMC Infect Dis 2019 Mar 12;19(1):250. Epub 2019 Mar 12.

Mahidol Oxford Tropical Medicine Research unit (MORU), 420/60 Rajvithi Road, Bangkok, 10400, Thailand.

Background: The WHO recommends single low-dose primaquine (SLDPQ, 0.25 mg/kg body weight) in falciparum-infected patients to block malaria transmission and contribute to eliminating multidrug resistant Plasmodium falciparum from the Greater Mekong Sub region (GMS). However, the anxiety regarding PQ-induced acute haemolytic anaemia in glucose-6-phosphate dehydrogenase deficiency (G6PDd) has hindered its use. Read More

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http://dx.doi.org/10.1186/s12879-019-3862-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6419451PMC
March 2019
2 Reads

Prevalence of G6PD Viangchan variant in malaria endemic areas in Lao PDR: an implication for malaria elimination by 2030.

Malar J 2019 Mar 12;18(1):75. Epub 2019 Mar 12.

Department of Community and Global Health, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.

Background: Primaquine is effective against the latent liver stage of Plasmodium vivax. Eliminating the latent liver stage of P. vivax is one of the necessary conditions to achieve the goal of malaria elimination in Lao People's Democratic Republic (PDR) by 2030. Read More

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http://dx.doi.org/10.1186/s12936-019-2715-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6416863PMC
March 2019
3 Reads

Etiology and Outcomes of Thrombotic Microangiopathies.

Clin J Am Soc Nephrol 2019 Apr 12;14(4):557-566. Epub 2019 Mar 12.

Service de Néphrologie-hypertension, Dialyses, Transplantation Rénale, Hôpital Bretonneau et hôpital Clocheville,

Background And Objectives: Thrombotic microangiopathies constitute a diagnostic and therapeutic challenge. Secondary thrombotic microangiopathies are less characterized than primary thrombotic microangiopathies (thrombotic thrombocytopenic purpura and atypical hemolytic and uremic syndrome). The relative frequencies and outcomes of secondary and primary thrombotic microangiopathies are unknown. Read More

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http://dx.doi.org/10.2215/CJN.11470918DOI Listing
April 2019
3 Reads

Intestinal transcriptional profiling reveals fava bean-induced immune response in DBA/1 mice.

Biol Res 2019 Mar 1;52(1). Epub 2019 Mar 1.

Department of Biochemistry and Molecular Biology, Hainan Medical College, Haikou, 571199, China.

Background: Fava beans (FBs) have long been used as food, and their principal disadvantage is derived from their haemotoxicity. We hypothesized that FB ingestion alters the intestinal gene expression pattern, thereby inducing an immune response.

Results: In-depth sequence analysis identified 769 differentially expressed genes (DEGs) associated with the intestine in FB-treated DBA/1 mouse intestines. Read More

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https://biolres.biomedcentral.com/articles/10.1186/s40659-01
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http://dx.doi.org/10.1186/s40659-019-0216-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396536PMC
March 2019
7 Reads

Premarital Screening and Genetic Counseling Program: Studies from an Endogamous Population.

Int J Appl Basic Med Res 2019 Jan-Mar;9(1):20-26

Division of Cancer and Genetics, Institute of Medical Genetics Building, School of Medicine, Cardiff University, Heath Park Cardiff CF14 4XN Cardiff, UK.

Background: Studies in Arab countries have shown a significant lack of knowledge of Premarital Screening and Genetic Counseling (PMSGC) Program. PMSGC can identify and modify, through prevention and management, some behavioral, medical, and other health risk factors known to impact pregnancy outcomes.

Objective: The aim of this study was to explore the knowledge, attitudes, and practice of Qatari's toward the premarital screening program and shedding more light on a complex matter. Read More

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http://dx.doi.org/10.4103/ijabmr.IJABMR_42_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6385533PMC
March 2019
6 Reads

An update on glucose-6-phosphate dehydrogenase deficiency in children from Brazzaville, Republic of Congo.

Malar J 2019 Feb 28;18(1):57. Epub 2019 Feb 28.

Fondation Congolaise pour la Recherche Médicale (FCRM), Brazzaville, Republic of Congo.

Background: Malaria transmission-blocking anti-malarial drugs, such as primaquine, offers an effective strategy for reducing the incidence of falciparum malaria. However, this drug induces haemolytic anaemia among glucose-6-phosphate dehydrogenase (G6PD) deficient individuals. The distribution of G6PD deficiency in Brazzaville, Republic of Congo and the association of G6PD deficiency with haemoglobin levels and blood cell counts were investigated. Read More

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http://dx.doi.org/10.1186/s12936-019-2688-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396490PMC
February 2019
2 Reads
3.109 Impact Factor

Glucose-6-Phosphate dehydrogenase deficiency incidence in a Hispanic population.

J Neonatal Perinatal Med 2019 Feb 4. Epub 2019 Feb 4.

Tecnologico de Monterrey, Escuela de Medicina y Ciencias de la Salud, Monterrey, Nuevo León, Mexico.

Glucose-6-phosphate dehydrogenase deficiency (D-G6PD) is a common erythroenzymopathy that needs to be addressed as an important public health issue. Proper population monitoring is needed to anticipate clinical complications. A joint venture between Genomi-k (a Mexican company focused on newborn screening) and several university researchers conducted a retrospetive study for D-G6PD based on 156,152 newborn screening reports belonging to the Mexican population comprising a period of 10 years. Read More

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http://dx.doi.org/10.3233/NPM-1831DOI Listing
February 2019
1 Read

Glucose-6-phosphate dehydrogenase deficiency and metabolic profiling in adolescence from the Chinese birth cohort: "Children of 1997".

Int J Cardiol 2019 Apr 31;281:146-149. Epub 2019 Jan 31.

School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China; City University of New York School of Public Health and Health Policy, New York, United States. Electronic address:

Background: Glucose-6-phosphate dehydrogenase (G6PD) deficiency affects 6.0% of the global population. G6PD deficiency has been associated with lower risk of cardiovascular disease and higher risk of diabetes, which could be etiologically informative, but these relations are uncertain. Read More

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http://dx.doi.org/10.1016/j.ijcard.2019.01.100DOI Listing
April 2019
1 Read

Glucose-6-phosphate dehydrogenase deficiency and risk of cardiovascular disease: A propensity score-matched study.

Atherosclerosis 2019 Mar 28;282:148-153. Epub 2019 Jan 28.

Dipartimento di Scienze Mediche, Chirurgiche e Sperimentali, Clinica Medica, University of Sassari, Italy; Baylor College of Medicine, One Baylor Plaza, Houston, TX, USA.

Background And Aims: Cardiovascular disease (CVD) is associated with high morbidity and mortality. Studies in animal models and humans suggested that glucose‒6‒phosphate dehydrogenase (G6PD) deficiency, a genetically inherited condition causing haemolytic anemia, may be a risk factor for CVD. This hypothesis was tested in a large cohort from Northern Sardinia, where the population prevalence of G6PD deficiency is the highest in the Mediterranean area. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00219150193004
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http://dx.doi.org/10.1016/j.atherosclerosis.2019.01.027DOI Listing
March 2019
23 Reads

Collider bias and the apparent protective effect of glucose-6-phosphate dehydrogenase deficiency on cerebral malaria.

Elife 2019 Jan 28;8. Epub 2019 Jan 28.

Nuffield Department of Medicine, Centre for Tropical Medicine and Global Health, University of Oxford, Oxford, United Kingdom.

Case fatality rates in severe falciparum malaria depend on the pattern and degree of vital organ dysfunction. Recent large-scale case-control analyses of pooled severe malaria data reported that glucose-6-phosphate dehydrogenase deficiency (G6PDd) was protective against cerebral malaria but increased the risk of severe malarial anaemia. A novel formulation of the balancing selection hypothesis was proposed as an explanation for these findings, whereby the selective advantage is driven by the competing risks of death from cerebral malaria and death from severe malarial anaemia. Read More

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http://dx.doi.org/10.7554/eLife.43154DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361583PMC
January 2019
1 Read

Molecular characterization and mapping of glucose-6-phosphate dehydrogenase (G6PD) mutations in the Greater Mekong Subregion.

Malar J 2019 Jan 23;18(1):20. Epub 2019 Jan 23.

Shoklo Malaria Research Unit, Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Mae Sot, Thailand.

Background: Plasmodium vivax malaria elimination can only be achieved by the deployment of 8-aminoquinolines (primaquine and tafenoquine) in combination with ACT to kill both blood and liver-stage parasites. However, primaquine and the other 8-aminoquinolines cause dose-dependent haemolysis in subjects with G6PD deficiency, an X-linked disorder of red blood cells that is very common in populations living in tropical and subtropical areas. In order to inform safer use of 8-aminoquinolines in the Greater Mekong Subregion, a multi-centre study was carried out to assess the prevalence of G6PD deficiency and to identify the main G6PD variants in samples collected in Cambodia, Lao PDR, Myanmar, Thailand and Vietnam. Read More

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https://malariajournal.biomedcentral.com/articles/10.1186/s1
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http://dx.doi.org/10.1186/s12936-019-2652-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343352PMC
January 2019
10 Reads

Prevalence of G6PD deficiency and molecular characterization of G202A, A376G and C563T polymorphisms in newborns in Southeastern Brazil.

Einstein (Sao Paulo) 2019 Jan 21;17(1):eAO4436. Epub 2019 Jan 21.

Faculdade PIO XII , Cariacica , ES , Brazil .

Objective: To evaluate the prevalence of G6PD deficiency and characterize G202A, A376G and C563T polymorphisms in neonates using molecular assays.

Methods: A total of one thousand samples were tested through quantitative analysis of enzyme activity, detecting 25 G6PD-deficient individuals. Patients identified as deficient were submitted to molecular analysis quantitative real-time polymerase chain reaction - (qPCR) to investigate the presence of variants associated with the deficiency. Read More

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http://dx.doi.org/10.31744/einstein_journal/2019AO4436DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6438675PMC
January 2019
1 Read

Bead-based assays to simultaneously detect multiple human inherited blood disorders associated with malaria.

Malar J 2019 Jan 21;18(1):14. Epub 2019 Jan 21.

Department of Immunology and Infection, London School of Hygiene & Tropical Medicine, London, UK.

Background: Glucose-6-phosphate dehydrogenase deficiency (G6PDd), haemoglobin C (HbC) and S (HbS) are inherited blood disorders (IBD) common in populations in malaria endemic areas. All are associated to some degree with protection against clinical malaria whilst additionally G6PDd is associated with haemolysis following treatment with 8-aminoquinolines. Measuring the prevalence of these inherited blood disorders in affected populations can improve understanding of disease epidemiology. Read More

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https://malariajournal.biomedcentral.com/articles/10.1186/s1
Publisher Site
http://dx.doi.org/10.1186/s12936-019-2648-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341711PMC
January 2019
10 Reads

Tafenoquine versus Primaquine to Prevent Relapse of Plasmodium vivax Malaria.

N Engl J Med 2019 01;380(3):229-241

From Universidad Peruana Cayetano Heredia, Lima, Peru (A.L.-C., R.C., M.C.); Fundação de Medicina Tropical Dr Heitor Vieira Dourado, Manaus (M.V.G.L., F.V., W.M.M., M.A.M.B., M.R.F.C.), and Fundação Oswaldo Cruz, Manguinhos, Rio de Janeiro (M.V.G.L.) - both in Brazil; Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam (T.T.H., C.H.N.); Universidad de Antioquia, Medellin (I.D.V.), Centro de Investigaciones Clinicas S.A.S de Cali, Cali (M.F.V.), and IMAT Oncomedica, Monteria (S.A.) - all in Colombia; Umphang Hospital, Tak (C.N.-l., R.P.), and Shoklo Malaria Research Unit, Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Mae Sot (C.S.C., F.H.N., G.B.) - both in Thailand; the Centre for Tropical Medicine and Global Health (C.S.C., F.H.N., G.B.) and the Oxford Centre for Clinical Tropical Medicine (B.A.), Nuffield Department of Medicine, University of Oxford, Oxford, GlaxoSmithKline, Stockley Park West (G.C., V.M.R., S.W.J., E.H., D.D.C., K.M., G.C.K.W.K., J.A.G.), and GlaxoSmithKline, Stevenage (L.K.) - all in the United Kingdom; Medicines for Malaria Venture, Geneva (S.D.); and GlaxoSmithKline, Collegeville, PA (V.M.W., J.J.B.).

Background: Tafenoquine, a single-dose therapy for Plasmodium vivax malaria, has been associated with relapse prevention through the clearance of P. vivax parasitemia and hypnozoites, termed "radical cure."

Methods: We performed a phase 3, prospective, double-blind, double-dummy, randomized, controlled trial to compare tafenoquine with primaquine in terms of safety and efficacy. Read More

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http://dx.doi.org/10.1056/NEJMoa1802537DOI Listing
January 2019
12 Reads
55.873 Impact Factor

Impact of glucose-6-phosphate dehydrogenase deficiency on dengue infection in Myanmar children.

PLoS One 2019 2;14(1):e0209204. Epub 2019 Jan 2.

Department of Tropical Hygiene, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.

Glucose-6-phosphate dehydrogenase (G6PD) deficiency may affect the clinical presentation of dengue due to the altered redox state in immune cells. We aimed to determine the association between G6PD deficiency and severity of dengue infection in paediatric patients in Myanmar. A cross-sectional study was conducted among paediatric patients aged 2-13 years with dengue in Yankin Children Hospital, Myanmar. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0209204PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6314580PMC
January 2019
1 Read
3.234 Impact Factor

Glucose-6-phosphate dehydrogenase deficiency increases cell adhesion molecules and activates human monocyte-endothelial cell adhesion: Protective role of l-cysteine.

Arch Biochem Biophys 2019 Mar 21;663:11-21. Epub 2018 Dec 21.

Department of Pediatrics and Center for Cardiovascular Diseases and Sciences, Louisiana State University Health Sciences Center-Shreveport, 1501 Kings Highway, Shreveport, LA, 71130, USA. Electronic address:

Glucose-6-phosphate dehydrogenase is a major enzyme that supplies the reducing agent nicotinamide adenine dinucleotide phosphate hydrogen (NADPH), which is required to recycle oxidized/glutathione disulfide (GSSH) to reduced glutathione (GSH). G6PD-deficient cells are susceptible to oxidative stress and a deficiency of GSH. Endothelial dysfunction is characterized by the loss of nitric oxide (NO) bioavailability, which regulates leukocyte adhesion to endothelium. Read More

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http://dx.doi.org/10.1016/j.abb.2018.12.023DOI Listing
March 2019
4 Reads

[Neonatal screening for glucose-6-phosphate dehydrogenase (G6PD) deficiency in Mauritania].

Pan Afr Med J 2018 25;30:224. Epub 2018 Jul 25.

Hôpital National de Nouakchott, Mauritanie.

Introduction: We conducted a cross-sectional descriptive study aiming to identify risk factors associated with G6PD deficiency, its frequency and geographic distribution in Nouakchott, in order to provide useful informations to monitor it. As this disease has never previously been studied in Mauritania, we tried to define the epidemiological profile and the burden of morbidity related to G6PD deficiency in a newborn population in two health structures in the city of Nouakchott.

Methods: This study was conducted in two hospitals in Nouakchott, at the Maternity and Infant Hospital and at the Health Center in Sebkha between August and October 2015. Read More

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http://dx.doi.org/10.11604/pamj.2018.30.224.13947DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6295302PMC
January 2019
2 Reads

Hemolytic jaundice induced by pharmacological dose ascorbic acid in glucose-6-phosphate dehydrogenase deficiency: A case report.

Medicine (Baltimore) 2018 Dec;97(51):e13588

Clinical Pharmacy, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China.

Rationale: Hemolysis induced by high dose ascorbic acid (AA) in patients with G6PD deficiency has been reported, but is rare. To our knowledge, this is the first reported case of a male with G6PD deficiency, coexpressed with cholecystolithiasis and cholecystitis, who developed extreme hemolysis and hyperbilirubinemia after receiving pharmacological doses ascorbic acid infusion.

Patient Concerns: A 27-year-old man history with glucose-6-phosphate dehydrogenase deficiency was admitted to our hospital because of cholecystolithiasis and cholecystitis. Read More

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http://dx.doi.org/10.1097/MD.0000000000013588DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6319863PMC
December 2018
2 Reads

Spectrum and hematological profile of hereditary anemia in North Indians: SGPGI experience.

Intractable Rare Dis Res 2018 Nov;7(4):258-263

Department of Medical Genetics, Sanjay Gandhi Post Graduate Institute of Medical Sciences (SGPGIMS), Lucknow, India.

Thalassemia and other hemoglobinopathies together with red cell enzymopathies are a common cause of anemia, which can be prevented by population screening and genetic counseling. This study was designed to screen the anemic patients for thalassemia, structural hemoglobin variants and red cell enzymopathies. A total of 17047 cases were evaluated from 2009 to 2018 for thalassemia, hemoglobin variants, glucose 6 phosphate dehydrogenase deficiency, pyruvate kinase deficiency and hereditary spherocytosis. Read More

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http://dx.doi.org/10.5582/irdr.2018.01093DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6290850PMC
November 2018
3 Reads

Molecular genotyping of G6PD mutations and Duffy blood group in Afro-descendant communities from Brazilian Amazon.

Genet Mol Biol 2018 Oct-Dec;41(4):758-765. Epub 2018 Nov 29.

Laboratório de Genética Humana e Médica, Instituto de Ciências Biológicas, Universidade Federal do Pará, Belém, PA, Brazil.

Glucose-6-phosphate dehydrogenase deficiency (G6PDd) and Duffy-negative blood group are two red blood cells variants that confer protection against malaria. In this study, the distribution of the most common G6PD variants (G6PD*A-, GGPD*A and G6PD Mediterranean) and the major alleles of the Duffy blood group (FY*A, FY*B and FY*BES) were investigated in an Afro-descendant population from state of Pará, Brazilian Amazon. G6PD variants and Duffy blood group alleles were determined by TaqMan SNP genotyping assay. Read More

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http://dx.doi.org/10.1590/1678-4685-GMB-2017-0253DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6415611PMC
November 2018
2 Reads

[Change of G6PD Activity in Children with Acute Leukemia and Its Clinical Significance].

Zhongguo Shi Yan Xue Ye Xue Za Zhi 2018 Dec;26(6):1649-1656

Second Department of Pediatrics,Affiliated Hospital of Zunyi Medical College/The Children's Hospital of Guizhou Province,Zunyi 563003,Guizhou Province, China.E-mail: cyz600@ 163.com.

Objective: To explore the change of G6PD activity in children with acute leukemia(AL)and its correlation with the clinical characteristics.

Methods: The G6PD activity in peripheral blood samples from 74 children disagnosed as AL (50 cases of ALL, and 24 cases of AML) was detected by Zinkham method recommended by WHO in 1967, and its relevance with clinical indicators was statistically analyzed. The peripheral blood samples of 70 healthy children were used as the controls. Read More

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http://dx.doi.org/10.7534/j.issn.1009-2137.2018.06.012DOI Listing
December 2018
21 Reads

[Genetic mutation screening of glucose-6-phosphate dehydrogenase deficiency in Dongguan district].

Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2018 Dec;35(6):840-843

Dongguan Institute of Reproduction and Genetics, Dongguan Maternal and Child Health Care Hospital, Guangdong 523000, China.

Objective: To determine the incidence and genotypes of glucose-6-phosphate dehydrogenase (G6PD) deficiency in Dongguan region of Guangdong Province and assess the efficacy and feasibility of flow-through hybridization.

Methods: Peripheral blood samples were randomly selected and detected by modified G6PD/6PGD ratio method. Flow-through hybridization was used to detect 14 G6PD mutations among all samples. Read More

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http://dx.doi.org/10.3760/cma.j.issn.1003-9406.2018.06.015DOI Listing
December 2018
2 Reads

Area of exposure and treatment challenges of malaria in Eritrean migrants: a GeoSentinel analysis.

Malar J 2018 Nov 29;17(1):443. Epub 2018 Nov 29.

University Hospital Institute for Infectious and Tropical Diseases, Aix-Marseille University, Marseille, France.

Background: Recent reports highlight malaria as a frequent diagnosis in migrants who originate from Eritrea. A descriptive analysis of GeoSentinel cases of malaria in Eritrean migrants was done together with a literature review to elucidate key attributes of malaria in this group with a focus on possible areas of acquisition of malaria and treatment challenges.

Results: A total of 146 cases were identified from the GeoSentinel database from 1999 through September 2017, with a marked increase in 2014 and 2015. Read More

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http://dx.doi.org/10.1186/s12936-018-2586-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6267801PMC
November 2018
5 Reads

Laparoscopic cholecystectomy and postoperative pain control in a patient with chronic non-spherocytic hemolytic anemia from glucose-6-phosphate dehydrogenase deficiency.

J Clin Anesth 2019 05 23;54:128-129. Epub 2018 Nov 23.

Department of Surgery, Nihonkai General Hospital, Akiho-cho, Sakata, Yamagata 998-8501, Japan.

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http://dx.doi.org/10.1016/j.jclinane.2018.10.029DOI Listing
May 2019
1 Read

G6PD deficiency, primaquine treatment, and risk of haemolysis in malaria-infected patients.

Malar J 2018 Nov 8;17(1):415. Epub 2018 Nov 8.

Microbiology Research Institute, National Autonomous University of Honduras, Tegucigalpa, Honduras.

Background: The incidence of malaria in the Americas has decreased markedly in recent years. Honduras and the other countries of Mesoamerica and the island of Hispaniola have set the goal of eliminating native malaria by the year 2020. To achieve this goal, Honduras has recently approved national regulations to expand the possibilities of a shortened double dose primaquine (PQ) treatment for vivax malaria. Read More

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https://malariajournal.biomedcentral.com/articles/10.1186/s1
Publisher Site
http://dx.doi.org/10.1186/s12936-018-2564-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6225638PMC
November 2018
30 Reads

Field evaluation of quantitative point of care diagnostics to measure glucose-6-phosphate dehydrogenase activity.

PLoS One 2018 2;13(11):e0206331. Epub 2018 Nov 2.

Global and Tropical Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, Australia.

Background: Glucose-6-Phosphate dehydrogenase (G6PD) deficiency is the most common enzymopathy worldwide, no reliable bedside diagnostic tests to quantify G6PD activity exist. This study evaluated two novel quantitative G6PD diagnostics.

Methods: Participants with known G6PD activity were enrolled in Bangladesh. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0206331PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6214512PMC
April 2019
3 Reads

Evaluating the performance of automated UV enzymatic assay for screening of glucose 6-phosphate dehydrogenase deficiency.

Int J Lab Hematol 2019 Apr 1;41(2):192-199. Epub 2018 Nov 1.

Department of Biochemistry, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.

Introduction: A precise and reliable screening assay for glucose 6-phosphate dehydrogenase (G6PD) deficiency would greatly help avoiding unwanted outcomes due to bilirubin neurotoxicity in neonatal jaundice and antimalarial-induced haemolytic anaemia in malaria patients. Currently, available assays are laborious and require sophisticated laboratory expertise. This study aimed to evaluate the performance of a recently introduced automated screening assay for G6PD deficiency by comparing with a routine spectrophotometric assay. Read More

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http://dx.doi.org/10.1111/ijlh.12943DOI Listing
April 2019
10 Reads

The association between glucose-6-phosphate dehydrogenase deficiency and abnormal blood pressure among prepregnant reproductive-age Chinese females.

Hypertens Res 2019 Jan 31;42(1):75-84. Epub 2018 Oct 31.

National Research Institute for Family Planning, Beijing, China.

The morbidity of hypertension is increasing among young adults worldwide, and glucose-6-phosphate dehydrogenase (G6PD) deficiency is a high-prevalence genetic disease. We investigated whether G6PD deficiency was associated with abnormal blood pressure (including elevated blood pressure and hypertension) among prepregnant reproductive-age females. We conducted a cross-sectional study in Shenzhen, which included 154 917 females aged 20-49 who participated in the National Free Pre-conception Check-up Projects supported by the Chinese government. Read More

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http://www.nature.com/articles/s41440-018-0118-1
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http://dx.doi.org/10.1038/s41440-018-0118-1DOI Listing
January 2019
8 Reads

Dietary restrictions for people with glucose-6-phosphate dehydrogenase deficiency.

Nutr Rev 2019 Feb;77(2):96-106

Department of Food Sciences, Faculty of Agriculture and Food Sciences, Université Laval, Québec City, Québec, Canada.

Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most common enzyme deficiency in the world and renders those affected susceptible to potentially severe oxidative hemolysis. Although the resulting hemolysis is most often associated with drug exposure, it has also been reported after consumption of certain foods. With the exception of review articles that reiterated the historical knowledge that fava beans can provoke severe oxidative hemolysis in individuals with G6PD deficiency, very few articles have examined the safety of other food ingredients and food additives for people with G6PD deficiency. Read More

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http://dx.doi.org/10.1093/nutrit/nuy053DOI Listing
February 2019
7 Reads

Glucose-6-phosphate dehydrogenase (G6PD) deficiency in Ethiopia: absence of common African and Mediterranean allelic variants in a nationwide study.

Malar J 2018 Oct 26;17(1):388. Epub 2018 Oct 26.

US President's Malaria Initiative, Malaria Branch, Division of Parasitic Diseases and Malaria, Centers for Disease Control and Prevention, Atlanta, GA, USA.

Background: Building on the declining trend of malaria in Ethiopia, the Federal Ministry of Health aims to eliminate malaria by 2030. As Plasmodium falciparum and Plasmodium vivax are co-endemic in Ethiopia, the use of primaquine is indicated for both transmission interruption and radical cure, respectively. However, the limited knowledge of the local prevalence of glucose-6-phosphate dehydrogenase (G6PD) deficiency and its associated variants has hindered the use of primaquine. Read More

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https://malariajournal.biomedcentral.com/articles/10.1186/s1
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http://dx.doi.org/10.1186/s12936-018-2538-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6204031PMC
October 2018
19 Reads
3.110 Impact Factor

Evaluation of a Novel Quantitative Test for Glucose-6-Phosphate Dehydrogenase Deficiency: Bringing Quantitative Testing for Glucose-6-Phosphate Dehydrogenase Deficiency Closer to the Patient.

Am J Trop Med Hyg 2019 Jan;100(1):213-221

Diagnostics Program, PATH, Seattle, Washington.

Glucose-6-phosphate dehydrogenase (G6PD) deficiency, a common genetic blood condition, can result in kernicterus at birth, and later in life as severe hemolysis on exposure to certain infections, foods, and drugs. The unavailability of point-of-care tests for G6PD deficiency is a barrier to routine curative treatment of malaria with 8-aminoquinolines, such as primaquine. Two quantitative reference tests (Trinity Biotech, Bray, Ireland and Pointe Scientific, Canton, MI; Cat No. Read More

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http://www.ajtmh.org/content/journals/10.4269/ajtmh.18-0612
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http://dx.doi.org/10.4269/ajtmh.18-0612DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6335905PMC
January 2019
39 Reads

Seroprevalence of Malaria and Hepatitis B Coinfection among Pregnant Women in Tamale Metropolis of Ghana: A Cross-Sectional Study.

Can J Infect Dis Med Microbiol 2018 24;2018:5610981. Epub 2018 Sep 24.

Department of Nursing, School of Allied Health Sciences (SAHS), University for Development Studies (UDS), Tamale, Ghana.

Background: Coinfections are becoming common risk factors that may contribute to the increased burden of morbidity in pregnancy. The aim of this study was to assess the seroprevalence of coinfections of malaria, hepatitis B (HBV), human immunodeficiency virus (HIV), and syphilis among pregnant women attending antenatal clinics (ANC) in the Tamale Metropolis.

Methods: By means of rapid diagnostic tests (RDTs), pregnant women attending the Tamale Teaching Hospital (TTH) were screened for malaria, HBV infection, HIV infection, and syphilis from March 2013 to February 2015. Read More

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https://www.hindawi.com/journals/cjidmm/2018/5610981/
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http://dx.doi.org/10.1155/2018/5610981DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6174787PMC
September 2018
15 Reads

Not the Typical Pneumonia: An Unusual Case of Rasburicase-induced Methomoglobinemia.

Cureus 2018 Aug 1;10(8):e3084. Epub 2018 Aug 1.

Critical Care, St Luke's Health System, Kansas City, USA.

We present a rare case of rasburicase-induced methemoglobinemia and hemolytic anemia in the setting of presumed glucose-6-phosphate dehydrogenase (G6PD) deficiency. A 78-year-old male with a known history of chronic lymphocytic leukemia presented to the clinic with fever of unknown origin. Laboratory results were significant for hyperuricemia. Read More

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https://www.cureus.com/articles/13537-not-the-typical-pneumo
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http://dx.doi.org/10.7759/cureus.3084DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6168055PMC
August 2018
12 Reads

Analysis of Glucose-6-Phosphate Dehydrogenase Genetic Polymorphism in the Hakka Population in Southern China.

Med Sci Monit 2018 Oct 13;24:7316-7321. Epub 2018 Oct 13.

Clinical Core Laboratory, Meizhou People's Hospital (Huangtang Hospital), Meizhou Hospital Affiliated to Sun Yat-sen University, Meizhou, Guangdong, China (mainland).

BACKGROUND In southern China, glucose-6-phosphate dehydrogenase (G6PD) deficiency is a significant health problem. The aim of this study was to investigate the molecular epidemiological characteristic of the G6PD gene among Chinese Hakka in southern Guangdong province. MATERIAL AND METHODS We screened 611 unrelated subjects for G6PD genetic polymorphism analyzed by a gene chip analysis for common Chinese G6PD mutations. Read More

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https://www.medscimonit.com/abstract/index/idArt/908402
Publisher Site
http://dx.doi.org/10.12659/MSM.908402DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6196584PMC
October 2018
3 Reads

Glucose-6-phosphate dehydrogenase activity measured by spectrophotometry and associated genetic variants from the Oromiya zone, Ethiopia.

Malar J 2018 Oct 12;17(1):358. Epub 2018 Oct 12.

Division of Infectious Diseases and Tropical Medicine, Medical Center of the University of Munich (LMU), Leopoldstrasse 5, 80802, Munich, Germany.

Background: The study aimed to gain first data on the prevalence of G6PD enzyme deficiency measured by spectrophotometry and associated genetic variants in Jimma and surroundings, Ethiopia. The area is a Plasmodium vivax endemic region, but 8-aminoquinolines such as primaquine are not recommended as G6PD testing is not available.

Methods: Healthy volunteers were recruited at Jimma University, Ethiopia. Read More

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https://malariajournal.biomedcentral.com/articles/10.1186/s1
Publisher Site
http://dx.doi.org/10.1186/s12936-018-2510-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6186078PMC
October 2018
24 Reads

Identification of Genetic Risk Factors for Neonatal Hyperbilirubinemia in Fujian Province, Southeastern China: A Case-Control Study.

Biomed Res Int 2018 12;2018:7803175. Epub 2018 Sep 12.

Center of Neonatal Screening, Fujian Provincial Maternity and Children's Hospital, Affiliated Hospital of Fujian Medical University, Fuzhou 350001, Fujian Province, China.

To date, the genetic risk factors for neonatal hyperbilirubinemia remain unknown in Southeastern China. This case-control study aimed to identify the genetic risk factors for neonatal hyperbilirubinemia in Fujian, Southeastern China. A total of 286 hyperbilirubinemic newborns were enrolled as a case group, and 250 randomly selected newborns without jaundice or with a bilirubin level that was lower than the threshold required for phototherapy served as controls. Read More

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http://dx.doi.org/10.1155/2018/7803175DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6157199PMC
January 2019
3 Reads

[Research Progress in Acute Hemolysis and Safe Blood Transfusion of Glucose-6-Phosphate Dehydrogenase Deficiency-Review].

Zhongguo Shi Yan Xue Ye Xue Za Zhi 2018 Oct;26(5):1569-1573

Department of Blood Transfusion, 181th Hospital of Chinese PLA, Guilin 541002, Guangxi Zhuang Autonomous Region.

Glucose-6-phosphate dehydrogenase deficiency (G6PD) is one of hereditary diseases sariously influencing the human health. G6PD is characterized by wide distribution, high incidence, inducing the hemolysis, complex mechanism of hemolysis and common occurence in children and so on. The blood transfusion is most effective method for acute ouset of hemolysis, but the risk is more high, thereby it is necessary to guarante the safety of blood transfusion. Read More

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http://dx.doi.org/10.7534/j.issn.1009-2137.2018.05.052DOI Listing
October 2018
5 Reads

[Clinical Features and Laboratory Data Analysis of Glucose-6- Phosphate Dehydrogenase Deficiency].

Zhongguo Shi Yan Xue Ye Xue Za Zhi 2018 Oct;26(5):1437-1441

Institute of Hematology and Blood Disease Hospital,Chinese Academy of Medical Sciences & Peking Union Medical

Objective: To explore clinical features and laboratory data of glucose-6-phosphate dehydrogenase(G6PD)deficiency and to investigate the relationship between them.

Methods: Clinical data of 43 patients with G6PD deficiency was analyzed, the statistical method was applied to investigate the relationship between clinical features and laboratory data.

Results: Among 43 patients,neonatal jaundice occurred as the first symptom in 10 cases,while acute hemolytic anemia occurred as the first symptom in 23 cases. Read More

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http://dx.doi.org/10.7534/j.issn.1009-2137.2018.05.030DOI Listing
October 2018
5 Reads

Hepatitis A Virus-induced Severe Hemolysis Complicated by Severe Glucose-6-Phosphate Dehydrogenase Deficiency.

Indian J Crit Care Med 2018 Sep;22(9):670-673

Institute of Critical Care Medicine, Max Super Speciality Hospital, New Delhi, India.

Glucose-6-phosphate dehydrogenase (G6PD) deficiency is an x-linked recessive genetic disorder with mutation in the G6PD gene. Defect in the enzyme G6PD causes red blood cells (RBCs) to breakdown prematurely causing hemolytic anemia. Hemolytic anemia is also a known hematological complication associated with viral hepatitis. Read More

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http://www.ijccm.org/text.asp?2018/22/9/670/241315
Publisher Site
http://dx.doi.org/10.4103/ijccm.IJCCM_260_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6161574PMC
September 2018
11 Reads

High cut-off membrane for in-vivo dialysis of free plasma hemoglobin in a patient with massive hemolysis.

BMC Nephrol 2018 Oct 4;19(1):250. Epub 2018 Oct 4.

Nephrology and Renal Transplant Unit, Hospital Clínic, Carrer Villaroel 170, 08036, Barcelona, Spain.

Background: The possibility of clearing Cell-free Plasma Hemoglobin (CPH) from human plasma may appear attractive, especially when considering the noxious effects that CPH has on the immune function and the renal damage caused by its filtration. The existence of the so-called High Cut-Off (HCO) filters, possessing pores as big as 60 kDa, could potentially allow the clearance of the αβ dimers (31.3 kDa), the form in which the α2β2 hemoglobin tetramers (62. Read More

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http://dx.doi.org/10.1186/s12882-018-1051-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6172805PMC
October 2018
3 Reads

Correcting glucose-6-phosphate dehydrogenase deficiency with a small-molecule activator.

Nat Commun 2018 10 2;9(1):4045. Epub 2018 Oct 2.

Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, CA, 94305, USA.

Glucose-6-phosphate dehydrogenase (G6PD) deficiency, one of the most common human genetic enzymopathies, is caused by over 160 different point mutations and contributes to the severity of many acute and chronic diseases associated with oxidative stress, including hemolytic anemia and bilirubin-induced neurological damage particularly in newborns. As no medications are available to treat G6PD deficiency, here we seek to identify a small molecule that corrects it. Crystallographic study and mutagenesis analysis identify the structural and functional defect of one common mutant (Canton, R459L). Read More

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http://dx.doi.org/10.1038/s41467-018-06447-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6168459PMC
October 2018
5 Reads
10.742 Impact Factor

The clinical impact of glucose-6-phosphate dehydrogenase deficiency in patients with sickle cell disease.

Curr Opin Hematol 2018 Nov;25(6):494-499

Laboratory of Transfusion Biology, Department of Pathology and Cell Biology, Columbia University Medical Center-New York Presbyterian Hospital, New York, New York, USA.

Purpose Of Review: Glucose-6-phosphate dehydrogenase (G6PD) deficiency and sickle cell disease (SCD) cause hemolysis, often occurring in individuals of African descent. These disorders co-occur frequently, and possibly interact, altering clinical outcomes in SCD. However, epidemiological investigations of SCD with G6PD deficiency have produced variable results. Read More

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http://dx.doi.org/10.1097/MOH.0000000000000455DOI Listing
November 2018
11 Reads

How I do in front of an hemolytic anemia of unknown etiology?

Ann Biol Clin (Paris) 2018 Oct;76(5):493-503

Groupement de coopération sanitaire de Saintonge, Centres hospitaliers de Saintes et Royan, Vaux-sur-mer, France, Service de médecine interne, Centre hospitalier de Royan, Vaux-sur-mer, France.

The most frequent causes of hemolytic anemias are immune or infectious diseases, drug induced hemolysis, thrombotic microangiopathies, hereditary spherocytosis, glucose-6-phosphate dehydrogenase or pyruvate kinase deficiencies, thalassemia's and sickle cell disease. Sometimes no cause is found because a rarer etiology is involved. The goal of this review is to remember some unfrequent constitutional or acquired causes and to point out difficulties to avoid wrong interpretations of analysis results. Read More

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http://dx.doi.org/10.1684/abc.2018.1381DOI Listing
October 2018
14 Reads