5,860 results match your criteria Glucose-6-Phosphate Dehydrogenase Deficiency


Impact of glucose-6-phosphate dehydrogenase deficiency on dengue infection in Myanmar children.

PLoS One 2019 2;14(1):e0209204. Epub 2019 Jan 2.

Department of Tropical Hygiene, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.

Glucose-6-phosphate dehydrogenase (G6PD) deficiency may affect the clinical presentation of dengue due to the altered redox state in immune cells. We aimed to determine the association between G6PD deficiency and severity of dengue infection in paediatric patients in Myanmar. A cross-sectional study was conducted among paediatric patients aged 2-13 years with dengue in Yankin Children Hospital, Myanmar. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0209204PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6314580PMC
January 2019
3.234 Impact Factor

Glucose-6-phosphate dehydrogenase deficiency increases cell adhesion molecules and activates human monocyte-endothelial cell adhesion: Protective role of l-cysteine.

Arch Biochem Biophys 2018 Dec 21;663:11-21. Epub 2018 Dec 21.

Department of Pediatrics and Center for Cardiovascular Diseases and Sciences, Louisiana State University Health Sciences Center-Shreveport, 1501 Kings Highway, Shreveport, LA, 71130, USA. Electronic address:

Glucose-6-phosphate dehydrogenase is a major enzyme that supplies the reducing agent nicotinamide adenine dinucleotide phosphate hydrogen (NADPH), which is required to recycle oxidized/glutathione disulfide (GSSH) to reduced glutathione (GSH). G6PD-deficient cells are susceptible to oxidative stress and a deficiency of GSH. Endothelial dysfunction is characterized by the loss of nitric oxide (NO) bioavailability, which regulates leukocyte adhesion to endothelium. Read More

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http://dx.doi.org/10.1016/j.abb.2018.12.023DOI Listing
December 2018
1 Read

[Neonatal screening for glucose-6-phosphate dehydrogenase (G6PD) deficiency in Mauritania].

Pan Afr Med J 2018 25;30:224. Epub 2018 Jul 25.

Hôpital National de Nouakchott, Mauritanie.

Introduction: We conducted a cross-sectional descriptive study aiming to identify risk factors associated with G6PD deficiency, its frequency and geographic distribution in Nouakchott, in order to provide useful informations to monitor it. As this disease has never previously been studied in Mauritania, we tried to define the epidemiological profile and the burden of morbidity related to G6PD deficiency in a newborn population in two health structures in the city of Nouakchott.

Methods: This study was conducted in two hospitals in Nouakchott, at the Maternity and Infant Hospital and at the Health Center in Sebkha between August and October 2015. Read More

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http://dx.doi.org/10.11604/pamj.2018.30.224.13947DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6295302PMC
January 2019

Hemolytic jaundice induced by pharmacological dose ascorbic acid in glucose-6-phosphate dehydrogenase deficiency: A case report.

Medicine (Baltimore) 2018 Dec;97(51):e13588

Clinical Pharmacy, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China.

Rationale: Hemolysis induced by high dose ascorbic acid (AA) in patients with G6PD deficiency has been reported, but is rare. To our knowledge, this is the first reported case of a male with G6PD deficiency, coexpressed with cholecystolithiasis and cholecystitis, who developed extreme hemolysis and hyperbilirubinemia after receiving pharmacological doses ascorbic acid infusion.

Patient Concerns: A 27-year-old man history with glucose-6-phosphate dehydrogenase deficiency was admitted to our hospital because of cholecystolithiasis and cholecystitis. Read More

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http://dx.doi.org/10.1097/MD.0000000000013588DOI Listing
December 2018

Spectrum and hematological profile of hereditary anemia in North Indians: SGPGI experience.

Intractable Rare Dis Res 2018 Nov;7(4):258-263

Department of Medical Genetics, Sanjay Gandhi Post Graduate Institute of Medical Sciences (SGPGIMS), Lucknow, India.

Thalassemia and other hemoglobinopathies together with red cell enzymopathies are a common cause of anemia, which can be prevented by population screening and genetic counseling. This study was designed to screen the anemic patients for thalassemia, structural hemoglobin variants and red cell enzymopathies. A total of 17047 cases were evaluated from 2009 to 2018 for thalassemia, hemoglobin variants, glucose 6 phosphate dehydrogenase deficiency, pyruvate kinase deficiency and hereditary spherocytosis. Read More

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http://dx.doi.org/10.5582/irdr.2018.01093DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6290850PMC
November 2018
2 Reads

Molecular genotyping of G6PD mutations and Duffy blood group in Afro-descendant communities from Brazilian Amazon.

Genet Mol Biol 2018 Oct-Dec;41(4):758-765. Epub 2018 Nov 29.

Laboratório de Genética Humana e Médica, Instituto de Ciências Biológicas, Universidade Federal do Pará, Belém, PA, Brazil.

Glucose-6-phosphate dehydrogenase deficiency (G6PDd) and Duffy-negative blood group are two red blood cells variants that confer protection against malaria. In this study, the distribution of the most common G6PD variants (G6PD*A-, GGPD*A and G6PD Mediterranean) and the major alleles of the Duffy blood group (FY*A, FY*B and FY*BES) were investigated in an Afro-descendant population from state of Pará, Brazilian Amazon. G6PD variants and Duffy blood group alleles were determined by TaqMan SNP genotyping assay. Read More

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http://dx.doi.org/10.1590/1678-4685-GMB-2017-0253DOI Listing
November 2018
1 Read

[Genetic mutation screening of glucose-6-phosphate dehydrogenase deficiency in Dongguan district].

Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2018 Dec;35(6):840-843

Dongguan Institute of Reproduction and Genetics, Dongguan Maternal and Child Health Care Hospital, Guangdong 523000, China.

Objective: To determine the incidence and genotypes of glucose-6-phosphate dehydrogenase (G6PD) deficiency in Dongguan region of Guangdong Province and assess the efficacy and feasibility of flow-through hybridization.

Methods: Peripheral blood samples were randomly selected and detected by modified G6PD/6PGD ratio method. Flow-through hybridization was used to detect 14 G6PD mutations among all samples. Read More

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http://dx.doi.org/10.3760/cma.j.issn.1003-9406.2018.06.015DOI Listing
December 2018

Area of exposure and treatment challenges of malaria in Eritrean migrants: a GeoSentinel analysis.

Malar J 2018 Nov 29;17(1):443. Epub 2018 Nov 29.

University Hospital Institute for Infectious and Tropical Diseases, Aix-Marseille University, Marseille, France.

Background: Recent reports highlight malaria as a frequent diagnosis in migrants who originate from Eritrea. A descriptive analysis of GeoSentinel cases of malaria in Eritrean migrants was done together with a literature review to elucidate key attributes of malaria in this group with a focus on possible areas of acquisition of malaria and treatment challenges.

Results: A total of 146 cases were identified from the GeoSentinel database from 1999 through September 2017, with a marked increase in 2014 and 2015. Read More

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http://dx.doi.org/10.1186/s12936-018-2586-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6267801PMC
November 2018

Laparoscopic cholecystectomy and postoperative pain control in a patient with chronic non-spherocytic hemolytic anemia from glucose-6-phosphate dehydrogenase deficiency.

J Clin Anesth 2018 Nov 23;54:128-129. Epub 2018 Nov 23.

Department of Surgery, Nihonkai General Hospital, Akiho-cho, Sakata, Yamagata 998-8501, Japan.

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http://dx.doi.org/10.1016/j.jclinane.2018.10.029DOI Listing
November 2018
1 Read

G6PD deficiency, primaquine treatment, and risk of haemolysis in malaria-infected patients.

Malar J 2018 Nov 8;17(1):415. Epub 2018 Nov 8.

Microbiology Research Institute, National Autonomous University of Honduras, Tegucigalpa, Honduras.

Background: The incidence of malaria in the Americas has decreased markedly in recent years. Honduras and the other countries of Mesoamerica and the island of Hispaniola have set the goal of eliminating native malaria by the year 2020. To achieve this goal, Honduras has recently approved national regulations to expand the possibilities of a shortened double dose primaquine (PQ) treatment for vivax malaria. Read More

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https://malariajournal.biomedcentral.com/articles/10.1186/s1
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http://dx.doi.org/10.1186/s12936-018-2564-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6225638PMC
November 2018
15 Reads

Evaluating the performance of automated UV enzymatic assay for screening of glucose 6-phosphate dehydrogenase deficiency.

Int J Lab Hematol 2018 Nov 1. Epub 2018 Nov 1.

Department of Biochemistry, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.

Introduction: A precise and reliable screening assay for glucose 6-phosphate dehydrogenase (G6PD) deficiency would greatly help avoiding unwanted outcomes due to bilirubin neurotoxicity in neonatal jaundice and antimalarial-induced haemolytic anaemia in malaria patients. Currently, available assays are laborious and require sophisticated laboratory expertise. This study aimed to evaluate the performance of a recently introduced automated screening assay for G6PD deficiency by comparing with a routine spectrophotometric assay. Read More

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http://dx.doi.org/10.1111/ijlh.12943DOI Listing
November 2018
7 Reads

The association between glucose-6-phosphate dehydrogenase deficiency and abnormal blood pressure among prepregnant reproductive-age Chinese females.

Hypertens Res 2019 Jan 31;42(1):75-84. Epub 2018 Oct 31.

National Research Institute for Family Planning, Beijing, China.

The morbidity of hypertension is increasing among young adults worldwide, and glucose-6-phosphate dehydrogenase (G6PD) deficiency is a high-prevalence genetic disease. We investigated whether G6PD deficiency was associated with abnormal blood pressure (including elevated blood pressure and hypertension) among prepregnant reproductive-age females. We conducted a cross-sectional study in Shenzhen, which included 154 917 females aged 20-49 who participated in the National Free Pre-conception Check-up Projects supported by the Chinese government. Read More

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http://www.nature.com/articles/s41440-018-0118-1
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http://dx.doi.org/10.1038/s41440-018-0118-1DOI Listing
January 2019
4 Reads

Dietary restrictions for people with glucose-6-phosphate dehydrogenase deficiency.

Nutr Rev 2019 Feb;77(2):96-106

Department of Food Sciences, Faculty of Agriculture and Food Sciences, Université Laval, Québec City, Québec, Canada.

Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most common enzyme deficiency in the world and renders those affected susceptible to potentially severe oxidative hemolysis. Although the resulting hemolysis is most often associated with drug exposure, it has also been reported after consumption of certain foods. With the exception of review articles that reiterated the historical knowledge that fava beans can provoke severe oxidative hemolysis in individuals with G6PD deficiency, very few articles have examined the safety of other food ingredients and food additives for people with G6PD deficiency. Read More

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http://dx.doi.org/10.1093/nutrit/nuy053DOI Listing
February 2019
4 Reads

Glucose-6-phosphate dehydrogenase (G6PD) deficiency in Ethiopia: absence of common African and Mediterranean allelic variants in a nationwide study.

Malar J 2018 Oct 26;17(1):388. Epub 2018 Oct 26.

US President's Malaria Initiative, Malaria Branch, Division of Parasitic Diseases and Malaria, Centers for Disease Control and Prevention, Atlanta, GA, USA.

Background: Building on the declining trend of malaria in Ethiopia, the Federal Ministry of Health aims to eliminate malaria by 2030. As Plasmodium falciparum and Plasmodium vivax are co-endemic in Ethiopia, the use of primaquine is indicated for both transmission interruption and radical cure, respectively. However, the limited knowledge of the local prevalence of glucose-6-phosphate dehydrogenase (G6PD) deficiency and its associated variants has hindered the use of primaquine. Read More

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https://malariajournal.biomedcentral.com/articles/10.1186/s1
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http://dx.doi.org/10.1186/s12936-018-2538-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6204031PMC
October 2018
9 Reads
3.110 Impact Factor

Evaluation of a Novel Quantitative Test for Glucose-6-Phosphate Dehydrogenase Deficiency: Bringing Quantitative Testing for Glucose-6-Phosphate Dehydrogenase Deficiency Closer to the Patient.

Am J Trop Med Hyg 2019 Jan;100(1):213-221

Diagnostics Program, PATH, Seattle, Washington.

Glucose-6-phosphate dehydrogenase (G6PD) deficiency, a common genetic blood condition, can result in kernicterus at birth, and later in life as severe hemolysis on exposure to certain infections, foods, and drugs. The unavailability of point-of-care tests for G6PD deficiency is a barrier to routine curative treatment of malaria with 8-aminoquinolines, such as primaquine. Two quantitative reference tests (Trinity Biotech, Bray, Ireland and Pointe Scientific, Canton, MI; Cat No. Read More

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http://www.ajtmh.org/content/journals/10.4269/ajtmh.18-0612
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http://dx.doi.org/10.4269/ajtmh.18-0612DOI Listing
January 2019
7 Reads

Seroprevalence of Malaria and Hepatitis B Coinfection among Pregnant Women in Tamale Metropolis of Ghana: A Cross-Sectional Study.

Can J Infect Dis Med Microbiol 2018 24;2018:5610981. Epub 2018 Sep 24.

Department of Nursing, School of Allied Health Sciences (SAHS), University for Development Studies (UDS), Tamale, Ghana.

Background: Coinfections are becoming common risk factors that may contribute to the increased burden of morbidity in pregnancy. The aim of this study was to assess the seroprevalence of coinfections of malaria, hepatitis B (HBV), human immunodeficiency virus (HIV), and syphilis among pregnant women attending antenatal clinics (ANC) in the Tamale Metropolis.

Methods: By means of rapid diagnostic tests (RDTs), pregnant women attending the Tamale Teaching Hospital (TTH) were screened for malaria, HBV infection, HIV infection, and syphilis from March 2013 to February 2015. Read More

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https://www.hindawi.com/journals/cjidmm/2018/5610981/
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http://dx.doi.org/10.1155/2018/5610981DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6174787PMC
September 2018
7 Reads

Not the Typical Pneumonia: An Unusual Case of Rasburicase-induced Methomoglobinemia.

Cureus 2018 Aug 1;10(8):e3084. Epub 2018 Aug 1.

Critical Care, St Luke's Health System, Kansas City, USA.

We present a rare case of rasburicase-induced methemoglobinemia and hemolytic anemia in the setting of presumed glucose-6-phosphate dehydrogenase (G6PD) deficiency. A 78-year-old male with a known history of chronic lymphocytic leukemia presented to the clinic with fever of unknown origin. Laboratory results were significant for hyperuricemia. Read More

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https://www.cureus.com/articles/13537-not-the-typical-pneumo
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http://dx.doi.org/10.7759/cureus.3084DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6168055PMC
August 2018
9 Reads

Analysis of Glucose-6-Phosphate Dehydrogenase Genetic Polymorphism in the Hakka Population in Southern China.

Med Sci Monit 2018 Oct 13;24:7316-7321. Epub 2018 Oct 13.

Clinical Core Laboratory, Meizhou People's Hospital (Huangtang Hospital), Meizhou Hospital Affiliated to Sun Yat-sen University, Meizhou, Guangdong, China (mainland).

BACKGROUND In southern China, glucose-6-phosphate dehydrogenase (G6PD) deficiency is a significant health problem. The aim of this study was to investigate the molecular epidemiological characteristic of the G6PD gene among Chinese Hakka in southern Guangdong province. MATERIAL AND METHODS We screened 611 unrelated subjects for G6PD genetic polymorphism analyzed by a gene chip analysis for common Chinese G6PD mutations. Read More

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https://www.medscimonit.com/abstract/index/idArt/908402
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http://dx.doi.org/10.12659/MSM.908402DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6196584PMC
October 2018
2 Reads

Glucose-6-phosphate dehydrogenase activity measured by spectrophotometry and associated genetic variants from the Oromiya zone, Ethiopia.

Malar J 2018 Oct 12;17(1):358. Epub 2018 Oct 12.

Division of Infectious Diseases and Tropical Medicine, Medical Center of the University of Munich (LMU), Leopoldstrasse 5, 80802, Munich, Germany.

Background: The study aimed to gain first data on the prevalence of G6PD enzyme deficiency measured by spectrophotometry and associated genetic variants in Jimma and surroundings, Ethiopia. The area is a Plasmodium vivax endemic region, but 8-aminoquinolines such as primaquine are not recommended as G6PD testing is not available.

Methods: Healthy volunteers were recruited at Jimma University, Ethiopia. Read More

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https://malariajournal.biomedcentral.com/articles/10.1186/s1
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http://dx.doi.org/10.1186/s12936-018-2510-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6186078PMC
October 2018
11 Reads

Identification of Genetic Risk Factors for Neonatal Hyperbilirubinemia in Fujian Province, Southeastern China: A Case-Control Study.

Biomed Res Int 2018 12;2018:7803175. Epub 2018 Sep 12.

Center of Neonatal Screening, Fujian Provincial Maternity and Children's Hospital, Affiliated Hospital of Fujian Medical University, Fuzhou 350001, Fujian Province, China.

To date, the genetic risk factors for neonatal hyperbilirubinemia remain unknown in Southeastern China. This case-control study aimed to identify the genetic risk factors for neonatal hyperbilirubinemia in Fujian, Southeastern China. A total of 286 hyperbilirubinemic newborns were enrolled as a case group, and 250 randomly selected newborns without jaundice or with a bilirubin level that was lower than the threshold required for phototherapy served as controls. Read More

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http://dx.doi.org/10.1155/2018/7803175DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6157199PMC
January 2019
1 Read

[Research Progress in Acute Hemolysis and Safe Blood Transfusion of Glucose-6-Phosphate Dehydrogenase Deficiency-Review].

Zhongguo Shi Yan Xue Ye Xue Za Zhi 2018 Oct;26(5):1569-1573

Department of Blood Transfusion, 181th Hospital of Chinese PLA, Guilin 541002, Guangxi Zhuang Autonomous Region.

Glucose-6-phosphate dehydrogenase deficiency (G6PD) is one of hereditary diseases sariously influencing the human health. G6PD is characterized by wide distribution, high incidence, inducing the hemolysis, complex mechanism of hemolysis and common occurence in children and so on. The blood transfusion is most effective method for acute ouset of hemolysis, but the risk is more high, thereby it is necessary to guarante the safety of blood transfusion. Read More

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http://dx.doi.org/10.7534/j.issn.1009-2137.2018.05.052DOI Listing
October 2018
4 Reads

[Clinical Features and Laboratory Data Analysis of Glucose-6- Phosphate Dehydrogenase Deficiency].

Zhongguo Shi Yan Xue Ye Xue Za Zhi 2018 Oct;26(5):1437-1441

Institute of Hematology and Blood Disease Hospital,Chinese Academy of Medical Sciences & Peking Union Medical

Objective: To explore clinical features and laboratory data of glucose-6-phosphate dehydrogenase(G6PD)deficiency and to investigate the relationship between them.

Methods: Clinical data of 43 patients with G6PD deficiency was analyzed, the statistical method was applied to investigate the relationship between clinical features and laboratory data.

Results: Among 43 patients,neonatal jaundice occurred as the first symptom in 10 cases,while acute hemolytic anemia occurred as the first symptom in 23 cases. Read More

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http://dx.doi.org/10.7534/j.issn.1009-2137.2018.05.030DOI Listing
October 2018
3 Reads

Hepatitis A Virus-induced Severe Hemolysis Complicated by Severe Glucose-6-Phosphate Dehydrogenase Deficiency.

Indian J Crit Care Med 2018 Sep;22(9):670-673

Institute of Critical Care Medicine, Max Super Speciality Hospital, New Delhi, India.

Glucose-6-phosphate dehydrogenase (G6PD) deficiency is an x-linked recessive genetic disorder with mutation in the G6PD gene. Defect in the enzyme G6PD causes red blood cells (RBCs) to breakdown prematurely causing hemolytic anemia. Hemolytic anemia is also a known hematological complication associated with viral hepatitis. Read More

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http://www.ijccm.org/text.asp?2018/22/9/670/241315
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http://dx.doi.org/10.4103/ijccm.IJCCM_260_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6161574PMC
September 2018
9 Reads

High cut-off membrane for in-vivo dialysis of free plasma hemoglobin in a patient with massive hemolysis.

BMC Nephrol 2018 Oct 4;19(1):250. Epub 2018 Oct 4.

Nephrology and Renal Transplant Unit, Hospital Clínic, Carrer Villaroel 170, 08036, Barcelona, Spain.

Background: The possibility of clearing Cell-free Plasma Hemoglobin (CPH) from human plasma may appear attractive, especially when considering the noxious effects that CPH has on the immune function and the renal damage caused by its filtration. The existence of the so-called High Cut-Off (HCO) filters, possessing pores as big as 60 kDa, could potentially allow the clearance of the αβ dimers (31.3 kDa), the form in which the α2β2 hemoglobin tetramers (62. Read More

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http://dx.doi.org/10.1186/s12882-018-1051-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6172805PMC
October 2018
1 Read

Correcting glucose-6-phosphate dehydrogenase deficiency with a small-molecule activator.

Nat Commun 2018 10 2;9(1):4045. Epub 2018 Oct 2.

Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, CA, 94305, USA.

Glucose-6-phosphate dehydrogenase (G6PD) deficiency, one of the most common human genetic enzymopathies, is caused by over 160 different point mutations and contributes to the severity of many acute and chronic diseases associated with oxidative stress, including hemolytic anemia and bilirubin-induced neurological damage particularly in newborns. As no medications are available to treat G6PD deficiency, here we seek to identify a small molecule that corrects it. Crystallographic study and mutagenesis analysis identify the structural and functional defect of one common mutant (Canton, R459L). Read More

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http://dx.doi.org/10.1038/s41467-018-06447-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6168459PMC
October 2018
3 Reads
10.742 Impact Factor

The clinical impact of glucose-6-phosphate dehydrogenase deficiency in patients with sickle cell disease.

Curr Opin Hematol 2018 Nov;25(6):494-499

Laboratory of Transfusion Biology, Department of Pathology and Cell Biology, Columbia University Medical Center-New York Presbyterian Hospital, New York, New York, USA.

Purpose Of Review: Glucose-6-phosphate dehydrogenase (G6PD) deficiency and sickle cell disease (SCD) cause hemolysis, often occurring in individuals of African descent. These disorders co-occur frequently, and possibly interact, altering clinical outcomes in SCD. However, epidemiological investigations of SCD with G6PD deficiency have produced variable results. Read More

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http://dx.doi.org/10.1097/MOH.0000000000000455DOI Listing
November 2018
8 Reads

How I do in front of an hemolytic anemia of unknown etiology?

Ann Biol Clin (Paris) 2018 Oct;76(5):493-503

Groupement de coopération sanitaire de Saintonge, Centres hospitaliers de Saintes et Royan, Vaux-sur-mer, France, Service de médecine interne, Centre hospitalier de Royan, Vaux-sur-mer, France.

The most frequent causes of hemolytic anemias are immune or infectious diseases, drug induced hemolysis, thrombotic microangiopathies, hereditary spherocytosis, glucose-6-phosphate dehydrogenase or pyruvate kinase deficiencies, thalassemia's and sickle cell disease. Sometimes no cause is found because a rarer etiology is involved. The goal of this review is to remember some unfrequent constitutional or acquired causes and to point out difficulties to avoid wrong interpretations of analysis results. Read More

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http://dx.doi.org/10.1684/abc.2018.1381DOI Listing
October 2018
11 Reads

[Effects of Yinzhihuang oral liquid and Lonicera japonica extract on hemolysis and hyperbilirubinemia in rats with glucose-6-phosphate dehydrogenase deficiency].

Zhongguo Dang Dai Er Ke Za Zhi 2018 Sep;20(9):769-774

Department of Neonatology, Nanfang Hospital of Southern Medical University, Guangzhou 510515, China.

Objective: To investigate the effects of different doses of Yinzhihuang oral liquid and different concentrations of Lonicera japonica extract on hemolysis and hyperbilirubinemia in rats with glucose-6-phosphate dehydrogenase (G6PD) deficiency.

Methods: Male Wistar rats were randomly divided into 10 groups (n=10 each): normal control group (untreated), negative control group (saline-treated), positive control group (primaquine-treated), low-, medium- and high-dose Yinzhihuang oral liquid groups (13.4, 26. Read More

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September 2018
9 Reads

Addressing the gender-knowledge gap in glucose-6-phosphate dehydrogenase deficiency: challenges and opportunities.

Int Health 2019 Jan;11(1):7-14

The Ethox Centre and Wellcome Centre for Ethics and Humanities, Nuffield Department of Population Health, University of Oxford, UK.

Glucose-6-phosphate dehyrdgoenase (G6PD) deficiency is a common X-linked genetic trait, with an associated enzyme phenotype, whereby males are either G6PD deficient or normal, but females exhibit a broader range of G6PD deficiencies, ranging from severe deficiency to normal. Heterozygous females typically have intermediate G6PD activity. G6PD deficiency has implications for the safe treatment for Plasmodium vivax malaria. Read More

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http://dx.doi.org/10.1093/inthealth/ihy060DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6314154PMC
January 2019
7 Reads

Transcutaneous bilirubin nomogram for Taiwanese newborns - A single center study.

Pediatr Neonatol 2018 Aug 2. Epub 2018 Aug 2.

Department of Pediatrics, National Cheng Kung University Hospital and College of Medicine, National Cheng Kung University, Tainan, Taiwan; Department of Pediatrics, E-Da Hospital, Kaohsiung, Taiwan. Electronic address:

Background: Hour-specific bilirubin nomogram has been recommended to predict postdischarge hyperbilirubinemia in newborns. However, it may not be applicable in Taiwan due to ethnic differences. The aim of this study was to construct a 12-h specific transcutaneous bilirubin (TCB) nomogram in newborns for clinical reference. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18759572183002
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http://dx.doi.org/10.1016/j.pedneo.2018.07.013DOI Listing
August 2018
15 Reads

New cases of Glucose-6-Phosphate Dehydrogenase deficiency in Pulmonary Arterial Hypertension.

PLoS One 2018 30;13(8):e0203493. Epub 2018 Aug 30.

Division of Endocrinology, Department of Medicine, College of Medicine, The University of Arizona, Tucson, Arizona, United States of America.

Pulmonary Arterial Hypertension (PAH) is a fatal disorder with limited treatment options and reduced life expectancy after diagnosis. Complex genetic backgrounds in PAH complicates identification of causative mutations that is essential for an understanding of the disease diagnostics and etiology especially for idiopathic PAH (iPAH). Hemolysis has been implicated as contributing to the pathobiology of PAH. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0203493PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6117081PMC
August 2018
13 Reads

Human red blood cell polymorphisms prevalent in Colombian population and its protective role against malaria.

Transfus Clin Biol 2018 Aug 10. Epub 2018 Aug 10.

University of Cartagena, Zaragocilla Campus, Cartagena, Colombia. Electronic address:

The populations infected with malaria have developed genetic defense mechanisms in order to protect themselves against the most serious complications of this disease. Those mechanisms have been associated from the perspective of co-adaptive process with some genetic diseases widely present in humans as sickle-cell disease, sickle cell trait and glucose-6-phosphate dehydrogenase deficiency (G6PD). Biochemically, polymorphic mutations at the erythrocyte level have been widely studied, however there is no clear statement of the mechanisms used for resistance against the causative agent of malaria. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S12467820183009
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http://dx.doi.org/10.1016/j.tracli.2018.08.001DOI Listing
August 2018
15 Reads

Transcutaneous bilirubinometer use and practices surrounding jaundice in 150 California newborn intensive care units.

J Perinatol 2018 Nov 17;38(11):1532-1535. Epub 2018 Aug 17.

Pediatrics- Division of Neonatology, LAC+USC Medical Center, Keck School of Medicine of USC, Los Angeles, CA, United States.

Objectives: Transcutaneous bilirubin measurements (TcBs) provide a noninvasive method for screening infants for hyperbilirubinemia and have been used extensively in term and late preterm newborns in well baby nurseries, offices, and outpatient clinics. Several studies have also demonstrated the utility of TcBs as a screening tool for infants > 28 weeks' gestation and their ability to reduce the need for blood sampling. The objectives of this study are to identify how often TcBs are used among California Newborn Intensive Care Units (NICUs) in preterm, late preterm and term infants, and other aspects of jaundice management. Read More

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http://dx.doi.org/10.1038/s41372-018-0154-3DOI Listing
November 2018
1 Read

High resolution melting curve analysis enables rapid and reliable detection of G6PD variants in heterozygous females.

BMC Genet 2018 Aug 10;19(1):58. Epub 2018 Aug 10.

Laboratory of Genetics and Genomics, Institute for Developing Science and Health Initiatives, Mohakhali, Dhaka, Bangladesh.

Background: Like glucose-6-phosphate dehydrogenase (G6PD) deficient hemizygous males and homozygous females, heterozygous females could also manifest hemolytic crisis, neonatal hyperbilirubinemia or kernicterus upon exposure to oxidative stress induced by certain foods such as fava beans, drugs or infections. Although hemizygous males and homozygous females are easily detected by conventional G6PD enzyme assay method, the heterozygous state could be missed by the conventional methods as the mosaic population of both normal and deficient RBCs circulates in the blood. Thus the present study aimed to apply high resolution melting (HRM) curve analysis approach to see whether HRM could be used as a supplemental approach to increase the chance of detection of G6PD heterozygosity. Read More

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http://dx.doi.org/10.1186/s12863-018-0664-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6086071PMC
August 2018
2 Reads
2.400 Impact Factor

Cloning and biochemical characterization of three glucose‑6‑phosphate dehydrogenase mutants presents in the Mexican population.

Int J Biol Macromol 2018 Nov 8;119:926-936. Epub 2018 Aug 8.

Laboratorio de Bioquímica Genética, Instituto Nacional de Pediatría, Secretaría de Salud, Mexico City 04530, Mexico. Electronic address:

The deficiency of glucose‑6‑phosphate dehydrogenase (G6PD) is one of the most common inborn errors of metabolism worldwide. This congenital disorder generally results from mutations that are spread throughout the entire gene of G6PD. Three single-point mutations for G6PD have been reported in the Mexican population and named Veracruz (Arg365His), G6PD Seattle (Asp282His), and G6PD Mexico DF (Thr65Ala), whose biochemical characterization have not yet been studied. Read More

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http://dx.doi.org/10.1016/j.ijbiomac.2018.08.025DOI Listing
November 2018
10 Reads

The gene spectrum of glucose-6-phosphate dehydrogenase (G6PD) deficiency in Guangdong province, China.

Gene 2018 Dec 1;678:312-317. Epub 2018 Aug 1.

Central Laboratory, Chaozhou Central Hospital Affiliated to Southern Medical University, Chaozhou, China. Electronic address:

Background: G6PD deficiency presents a higher incidence rate in southern China. Many variants of G6PD resulted from point mutations in the G6PD gene, which lead to decrease of enzyme activity. The objective of this study was to analyze the genotype of G6PD deficiency in four regions of Guangdong province. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03781119183084
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http://dx.doi.org/10.1016/j.gene.2018.07.068DOI Listing
December 2018
10 Reads

Glucose-6-Phosphate Dehydrogenase Deficiency is Associated with Cardiovascular Disease in U.S. Military Centers.

Tex Heart Inst J 2018 06 1;45(3):144-150. Epub 2018 Jun 1.

Glucose-6-phosphate dehydrogenase (G6PD) protects erythrocytes from oxidative stress and hemolysis; G6PD deficiency is the most prevalent enzymopathy. The United States military routinely performs tests to prevent exposing G6PD-deficient personnel to antimalarial drugs that might cause life-threatening hemolytic reactions. In addition, G6PD is a key determinant of vascular function, and its deficiency can lead to impaired nitric oxide production and greater vascular oxidant stress-precursors to atherosclerosis and cardiovascular disease. Read More

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http://dx.doi.org/10.14503/THIJ-16-6052DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6059509PMC
June 2018
8 Reads

Low and heterogeneous prevalence of glucose-6-phosphate dehydrogenase deficiency in different settings in Ethiopia using phenotyping and genotyping approaches.

Malar J 2018 Aug 2;17(1):281. Epub 2018 Aug 2.

Armauer Hansen Research Institute (AHRI), Addis Ababa, Ethiopia.

Background: 8-Aminoquinolines such as primaquine clear mature Plasmodium falciparum gametocytes that are responsible for transmission from human to mosquitoes and bring radical cure in Plasmodium vivax by clearing dormant liver stages. Deployment of primaquine is thus of relevance for malaria elimination efforts but challenged by the widespread prevalence of glucose-6-phosphate dehydrogenase deficiency (G6PDd) in endemic countries since primaquine in G6PDd individuals may lead to acute haemolysis. In this study, the prevalence of G6PDd was investigated in different settings in Ethiopia using phenotyping and genotyping approaches. Read More

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https://malariajournal.biomedcentral.com/articles/10.1186/s1
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http://dx.doi.org/10.1186/s12936-018-2437-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6071387PMC
August 2018
5 Reads

Rare Case of Transcutaneous Oxygen Desaturation in a Cancer Patient: A Case Report and Diagnostic Approach for a Recurrent Problem.

A A Pract 2018 Jul 25. Epub 2018 Jul 25.

Department of Intensive Care Medicine.

We present a case of a 73-year-old cancer patient with low transcutaneous oxygen saturation who was transferred to the intensive care unit after deployment of the rapid response team. Differential diagnosis remained broad until methemoglobinemia (MetHb) was detected. MetHb was induced by administration of rasburicase, which was given to prevent tumor lysis syndrome. Read More

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http://dx.doi.org/10.1213/XAA.0000000000000855DOI Listing
July 2018
7 Reads

Mutation of glucose-6-phosphate dehydrogenase deficiency in Chinese Han children in eastern Fujian.

Medicine (Baltimore) 2018 Jul;97(30):e11553

Neonatal Screening Center.

We aim to investigate the mutation types of glucose-6-phosphate dehydrogenase (G6PD) deficiency in Chinese Han children in eastern Fujian Province.A total of 904 Chinese Han neonates (male: 733 with positive G6PD deficiency and 28 with weakly positive deficiency; female: 73 with positive G6PD deficiency and 70 with weakly positive deficiency) received G6PD screening in our center from January 2014 to December 2016 were included in this study. Additionally, 904 age-matched normal Chinese Han individuals (male: 761; female: 143) were selected as control. Read More

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http://dx.doi.org/10.1097/MD.0000000000011553DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6078762PMC
July 2018
5 Reads
5.723 Impact Factor

Frequency of Inborn Errors of Metabolism in a Northeastern Iranian Sample with High Consanguinity Rates.

Hum Hered 2018 24;83(2):71-78. Epub 2018 Jul 24.

Objective: Inborn errors of metabolism (IEMs) are disorders with various manifestations that occur mainly in the pediatric population. In countries where consanguineous marriage is common, the association between consanguinity and IEMs is highly important. No studies have been conducted in Iran examining the impact of consanguinity on IEMs. Read More

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http://dx.doi.org/10.1159/000488876DOI Listing
July 2018
1 Read
1.474 Impact Factor

Hemolysis and Glucose-6-Phosphate Dehydrogenase Deficiency-Related Neonatal Hyperbilirubinemia.

Neonatology 2018 25;114(3):223-225. Epub 2018 Jun 25.

Stanford University School of Medicine, Stanford, California, USA.

Background: Glucose-6-phosphate dehydrogenase (G6PD) deficiency is a common enzyme deficiency affecting more than 300 million individuals worldwide. Extreme neonatal hyperbilirubinemia, with its severe sequelae of bilirubin neurotoxicity and the potential of death, is the most devastating manifestation of G6PD deficiency. In a recent review of Favism, Luzzatto and Arese state that the pathophysiology of jaundice in G6PD-deficient neonates is different from that of favism, as there is little evidence of hemolysis in these infants. Read More

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http://dx.doi.org/10.1159/000489820DOI Listing
June 2018
5 Reads

Red Blood Cell Homeostasis: Mechanisms and Effects of Microvesicle Generation in Health and Disease.

Front Physiol 2018 8;9:703. Epub 2018 Jun 8.

Department of Biochemistry, Radboud University Medical Center, Nijmegen, Netherlands.

Red blood cells (RBCs) generate microvesicles to remove damaged cell constituents such as oxidized hemoglobin and damaged membrane constituents, and thereby prolong their lifespan. Damage to hemoglobin, in combination with altered phosphorylation of membrane proteins such as band 3, lead to a weakening of the binding between the lipid bilayer and the cytoskeleton, and thereby to membrane budding and microparticle shedding. Microvesicle generation is disturbed in patients with RBC-centered diseases, such as sickle cell disease, glucose 6-phosphate dehydrogenase deficiency, spherocytosis or malaria. Read More

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http://dx.doi.org/10.3389/fphys.2018.00703DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6002509PMC
June 2018
3 Reads

Comparison of glucose-6 phosphate dehydrogenase status by fluorescent spot test and rapid diagnostic test in Lao PDR and Cambodia.

Malar J 2018 Jun 22;17(1):243. Epub 2018 Jun 22.

Lao-Oxford-Mahosot Hospital-Wellcome Trust Research Unit, Vientiane, Lao PDR.

Background: Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most common enzymopathy worldwide. Primaquine is the only licensed drug that effectively removes Plasmodium vivax hypnozoites from the human host and prevents relapse. While well tolerated by most recipients, primaquine can cause haemolysis in G6PD deficient individuals and is, therefore, underused. Read More

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http://dx.doi.org/10.1186/s12936-018-2390-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6013858PMC
June 2018
18 Reads
3.110 Impact Factor

Corrigendum to 'Two novel DNA variants associated with glucose-6-phosphate dehydrogenase deficiency found in Argentine pediatric patients' [Clin. Biochem. 49 (2016) 808-810].

Clin Biochem 2018 08 21;58:131. Epub 2018 Jun 21.

Servicio de Hematología-Oncología, Hospital de Pediatría "Prof. Dr. Juan P. Garrahan,", Combate de los Pozos 1881, C1245AAM Buenos Aires, Argentina. Electronic address:

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http://dx.doi.org/10.1016/j.clinbiochem.2018.06.005DOI Listing
August 2018
18 Reads

Indirect neonatal hyperbilirubinemia in hospitalized neonates on the Thai-Myanmar border: a review of neonatal medical records from 2009 to 2014.

BMC Pediatr 2018 Jun 12;18(1):190. Epub 2018 Jun 12.

Shoklo Malaria Research Unit, Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Mae Sot, Thailand.

Background: Indirect neonatal hyperbilirubinemia (INH) is a common neonatal disorder worldwide which can remain benign if prompt management is available. However there is a higher morbidity and mortality risk in settings with limited access to diagnosis and care. The manuscript describes the characteristics of neonates with INH, the burden of severe INH and identifies factors associated with severity in a resource-constrained setting. Read More

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http://dx.doi.org/10.1186/s12887-018-1165-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5998587PMC
June 2018
10 Reads

B/L Basal Ganglia Lesions in a Child Leading to a Diagnosis of Glucose-6-Phosphate Dehydrogenase Deficiency.

Ann Neurosci 2018 Apr 21;25(1):50-52. Epub 2017 Nov 21.

Department of Radiodiagnosis and Imaging, PGIMER, Chandigarh, India.

Bilateral basal ganglia lesions are a common non-specific finding seen in many diseases. One of the differential diagnoses for it, in a child, is kernicterus occurring due to hyperbilirubinemia. Glucose-6-phosphate dehydrogenase (G6PD) deficiency is a common cause of severe hyperbilirubinemia. Read More

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https://www.karger.com/Article/FullText/481907
Publisher Site
http://dx.doi.org/10.1159/000481907DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5981589PMC
April 2018
11 Reads

Prevalence and risk factors for asymptomatic malaria and genotyping of glucose 6-phosphate (G6PD) deficiencies in a vivax-predominant setting, Lao PDR: implications for sub-national elimination goals.

Malar J 2018 Jun 1;17(1):218. Epub 2018 Jun 1.

Malaria Elimination Initiative, Institute for Global Health Sciences, University of California, San Francisco, CA, USA.

Background: Lao People Democratic Republic (PDR; Laos), a landlocked country in Southeast Asia, has made important progress in reducing malaria morbidity and mortality in the past 5-6 years, and the northern provinces have very low reported incidence. To support national progress towards elimination, it is critical to verify and understand these changes in disease burden.

Methods: A two-stage cluster cross-sectional survey was conducted in four districts within four northern provinces (Khua, Phongsaly Province; Paktha, Bokeo Province; Nambak, Luang Prabang, and Muang Et, Huaphanh Province). Read More

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http://dx.doi.org/10.1186/s12936-018-2367-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5984820PMC
June 2018
1 Read

New Diagnosis of G6PD Deficiency Presenting as Severe Rhabdomyolysis.

Cureus 2018 Mar 28;10(3):e2387. Epub 2018 Mar 28.

Hematology and Medical Oncology, Cleveland Clinic Ohio.

A 24-year-old African-American man presented with malaise and low back pain and was found to have acute severe rhabdomyolysis followed by acute hemolysis. Glucose-6-phosphate dehydrogenase (G6PD) deficiency was suspected by the presence of blister cells on peripheral smear and was confirmed by a low enzyme activity assay. Our patient reported playing football, along with upper respiratory infection symptoms, prior to presentation. Read More

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http://dx.doi.org/10.7759/cureus.2387DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5973499PMC
March 2018
3 Reads

G6PD as a predictive marker for glioma risk, prognosis and chemosensitivity.

J Neurooncol 2018 Sep 29;139(3):661-670. Epub 2018 May 29.

Department of Laboratory Medicine, China Medical University Hospital, #2 Yude Road, Taichung, 40447, Taiwan, ROC.

Purpose: Glucose-6-phosphate dehydrogenase (G6PD) is a key enzyme preventing cells from oxidative damage and has been reported to have tumor-promoting roles. This study aims to comprehensively evaluate the predictive values of G6PD on brain tumor risk, prognosis and chemo-resistance.

Methods: A retrospective 13-year cohort study analyzing cancer risk using the Taiwan National Health Insurance Research Database (4066 G6PD deficiency patients and 16,264 controls) was conducted. Read More

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http://dx.doi.org/10.1007/s11060-018-2911-8DOI Listing
September 2018