Biochem Biophys Res Commun 2020 03 21;524(1):89-95. Epub 2020 Jan 21.
Department of Biotechnology and Bioinformatics, Korea University, Sejong, 30019, Republic of Korea. Electronic address:
Glycogen storage disease type Ib (GSD-Ib), caused by a deficiency in glucose-6-phosphate transporter (G6PT), is characterized by disrupted glucose homeostasis, inflammatory bowel disease, neutropenia, and neutrophil dysfunction. The purpose of this study was to investigate the role of G6PT on macrophage functions and metabolism. Peritoneal macrophages of G6pt mice were lower in number and their effector functions including migration, superoxide production, and phagocytosis were impaired. Read More