Differential actions of PPAR-α and PPAR-β/δ on beige adipocyte formation: A study in the subcutaneous white adipose tissue of obese male mice.
- Tamiris Lima Rachid,
- Flavia Maria Silva-Veiga,
- Francielle Graus-Nunes,
- Isabele Bringhenti,
- Carlos Alberto Mandarim-de-Lacerda,
- Vanessa Souza-Mello
PLoS One 2018 19;13(1):e0191365. Epub 2018 Jan 19.
Laboratory of Morphometry, Metabolism, and Cardiovascular Diseases, Biomedical Center, Institute of Biology, State University of Rio de Janeiro, Rio de Janeiro, Brazil.
Background And Aims: Obesity compromises adipocyte physiology. PPARs are essential to adipocyte plasticity, but its isolated role in the browning phenomenon is not clear. This study aimed to examine whether activation of PPAR-α or PPAR-β/δ could induce beige cell depots in the subcutaneous white adipose tissue of diet-induced obese mice. Read More