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    14814 results match your criteria Glucose Intolerance

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    Acute, but not Chronic, Exposure to Arsenic Provokes Glucose Intolerance in Rats: Possible Roles for Oxidative Stress and the Adrenergic Pathway.
    Can J Diabetes 2017 Feb 21. Epub 2017 Feb 21.
    Department of Pharmacology and Toxicology, School of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
    Objectives: Health problems due to heavy metals have become a worldwide concern. Along with its carcinogenicity, arsenic exposure results in impairment of glucose metabolism and insulin secretion as well as altered gene expression and signal transduction. However, the exact mechanism behind the behaviour of arsenic on glucose homeostasis and insulin secretion has not yet been fully understood. Read More

    Combined long-term caffeine intake and exercise inhibits the development of diabetic nephropathy in OLETF rats.
    J Appl Physiol (1985) 2017 Feb 23:jap.00278.2016. Epub 2017 Feb 23.
    Graduate School of Health and Sports Sciences, Juntendo University.
    This study was performed to examine the effects of long-term caffeine-intake, with and without exercise, on the progression of diabetic nephropathy (DN) in an obese diabetic rat model. Thirty-two male Otsuka Long Evans Tokushima Fatty (OLETF) rats were assigned to sedentary (OLETF-Sed), exercise (OLETF-Ex), caffeine-intake (OLETF-Caf), and combined (OLETF-Caf & Ex) groups. Caffeine-intake groups were fed rat chow containing caffeine (90. Read More

    [Pancreatic infringement exocrine and endocrine in cystic fibrosis].
    Arch Pediatr 2016 Dec;23(12S):12S21-12S32
    Centre de ressources et de compétences de la mucoviscidose Reims, American Memorial Hospital CHU Reims; INSERM UMRS 903 Reims, France.
    The exocrine pancreatic insufficiency affects more than 80% of cystic fibrosis (CF) infants. Pancreatic insufficiency is diagnosed by low levels of fecal elastase. An optimal caloric intake, a pancreatic enzyme treatment are the keys to maintain a good nutritional status. Read More

    Impaired glucose tolerance after streptozotocin microinjection into the mediodorsal prefrontal cortex of the rat.
    Physiol Int 2016 Dec;103(4):403-412
    1 Institute of Physiology, School of Medicine, University of Pécs , Pécs, Hungary.
    The mediodorsal prefrontal cortex (mdPFC) is a key structure of the central glucose-monitoring (GM) neural network. Previous studies indicate that intracerebral streptozotocin (STZ) microinjection-induced destruction of local chemosensory neurons results in feeding and metabolic alterations. The present experiments aimed to examine whether STZ microinjection into the mdPFC causes metabolic deficits. Read More

    ER Stress Protein CHOP Mediates Insulin Resistance by Modulating Adipose Tissue Macrophage Polarity.
    Cell Rep 2017 Feb;18(8):2045-2057
    Department of Metabolism and Diabetes, Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi 980-8575, Japan; Agency for Medical Research and Development-Core Research for Evolutional Medical Science and Technology (AMED-CREST), Japan Agency for Medical Research and Development, Chiyoda-ku, Tokyo 100-1004, Japan. Electronic address:
    Obesity represents chronic inflammatory states promoted by pro-inflammatory M1-macrophage infiltration into white adipose tissue (WAT), thereby inducing insulin resistance. Herein, we demonstrate the importance of an ER stress protein, CHOP, in determining adipose tissue macrophage (ATM) polarity and systemic insulin sensitivity. A high-fat diet (HFD) enhances ER stress with CHOP upregulation in adipocytes. Read More

    Can FIB4 and NAFLD fibrosis scores help endocrinologists refer patients with non-alcoholic fat liver disease to a hepatologist?
    Arch Endocrinol Metab 2017 Feb 13. Epub 2017 Feb 13.
    Unidade de Clínica Médica, Hospital de Clínicas, Universidade Federal do Paraná (UFPR), Curitiba, PR, Brasil.
    Objective: The objective of this study is to evaluate the performance of mathematical models used in non-invasive diagnosis of liver fibrosis in nonalcoholic fatty liver disease (NAFLD) patients to determine when the patient needs to be referred to a hepatologist.

    Subjects And Methods: Patients referred by endocrinologists to the liver outpatient departments in two hospitals in Curitiba, Brazil, over a 72-month period were analyzed. The results calculated using the APRI, FIB 4, FORNS and NAFLD Fibrosis Score non-invasive liver fibrosis assessment models were analyzed and compared with histological staging of this population. Read More

    The renal consequences of maternal obesity in offspring are overwhelmed by postnatal high fat diet.
    PLoS One 2017 22;12(2):e0172644. Epub 2017 Feb 22.
    Department of Medicine, Kolling Institute, University of Sydney, Sydney, Australia.
    Aims/hypothesis: Developmental programming induced by maternal obesity influences the development of chronic disease in offspring. In the present study, we aimed to determine whether maternal obesity exaggerates obesity-related kidney disease.

    Methods: Female C57BL/6 mice were fed high-fat diet (HFD) for six weeks prior to mating, during gestation and lactation. Read More

    DJ-1 maintains energy and glucose homeostasis by regulating the function of brown adipose tissue.
    Cell Discov 2017 14;3:16054. Epub 2017 Feb 14.
    State Key Laboratory of Brain and Cognitive Sciences, Institute of Biophysics, Chinese Academy of Sciences , Beijing, China.
    DJ-1 protein is involved in multiple physiological processes, including Parkinson's disease. However, the role of DJ-1 in the metabolism is largely unknown. Here we found that DJ-1 maintained energy balance and glucose homeostasisvia regulating brown adipose tissue (BAT) activity. Read More

    An Intestinal Farnesoid X Receptor-Ceramide Signaling Axis Modulates Hepatic Gluconeogenesis in Mice.
    Diabetes 2017 Mar 8;66(3):613-626. Epub 2016 Nov 8.
    Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD
    Increasing evidence supports the view that intestinal farnesoid X receptor (FXR) is involved in glucose tolerance and that FXR signaling can be profoundly impacted by the gut microbiota. Selective manipulation of the gut microbiota-FXR signaling axis was reported to significantly impact glucose intolerance, but the precise molecular mechanism remains largely unknown. Here, caffeic acid phenethyl ester (CAPE), an over-the-counter dietary supplement and an inhibitor of bacterial bile salt hydrolase, increased levels of intestinal tauro-β-muricholic acid, which selectively suppresses intestinal FXR signaling. Read More

    The Loss Of Macrophage Fatty Acid Oxidation Does Not Potentiate Systemic Metabolic Dysfunction.
    Am J Physiol Endocrinol Metab 2017 Feb 21:ajpendo.00408.2016. Epub 2017 Feb 21.
    Johns Hopkins University
    Fatty acid oxidation in macrophages has been suggested to play a causative role in high-fat diet-induced metabolic dysfunction, particularly in the etiology of adipose driven insulin resistance. To understand the contribution of macrophage fatty acid oxidation directly to metabolic dysfunction in high-fat diet-induced obesity, we generated mice with a myeloid-specific knockout of carnitine palmitoyltransferase 2 (CPT2 Mϕ-KO), an obligate step in mitochondrial long-chain fatty acid oxidation. While fatty acid oxidation was clearly induced upon IL-4 stimulation, fatty acid oxidation deficient CPT2 Mϕ-KO bone marrow derived macrophages (BMDM) displayed canonical markers of M2 polarization following IL-4 stimulation in vitro. Read More

    CTRP7 deletion attenuates obesity-linked glucose intolerance, adipose tissue inflammation, and hepatic stress.
    Am J Physiol Endocrinol Metab 2017 Feb 21:ajpendo.00344.2016. Epub 2017 Feb 21.
    Johns Hopkins University
    Chronic low-grade inflammation and cellular stress are important contributors to obesity-linked metabolic dysfunction. Here, we uncover an immune-metabolic role for C1q/TNF-related protein 7 (CTRP7), a secretory protein of the C1q family with previously unknown function. In obese humans, circulating CTRP7 levels were markedly elevated and positively correlated with BMI, glucose, insulin, insulin resistance index, hemoglobin A1c, and triglyceride levels. Read More

    Cerebral ischemia-induced elevation of hepatic inflammatory factors accompanied by glucose intolerance suppresses hypothalamic orexin-A-mediated vagus nerve activation.
    Brain Res 2017 Feb 18. Epub 2017 Feb 18.
    Department of Clinical Pharmacy, School of Pharmaceutical Sciences, Kobe Gakuin University. Electronic address:
    Activation of vagus nerve exerts orexin-A (OXA)-mediated suppression of post-ischemic glucose intolerance and cerebral ischemic neuronal damage. Cerebral ischemia induces hepatic inflammatory factors and contributes to the development of hepatic insulin resistance by activating sympathetic nerves. However, it is not enough to understand whether OXA regulates these phenomena through activation of vagus nerve. Read More

    Changes in Body Mass Index in Pheochromocytoma Patients Following Adrenalectomy.
    Horm Metab Res 2017 Feb 21. Epub 2017 Feb 21.
    Medizinische Klinik und Poliklinik IV, Endocrine Research Unit, Klinikum der Universität München, LMU, Ziemssenstr. 1, Munich, Germany.
    Catecholamine excess from pheochromocytoma results in cardiovascular symptoms such as arterial hypertension and tachycardia and induces metabolic alterations including glucose intolerance and increase in resting metabolic rate. The objective of our study was to investigate the effect of surgical cure of pheochromocytoma on body-mass-index and the correlation of body-mass-index changes to preoperative endocrine parameters. Pheochromocytoma patients from the Munich ENSAT Registry were matched (1:2) for age and gender to patients from the German Conn's Registry, who had undergone surgery for aldosterone-producing-adenomas. Read More

    Physicians' Experiences as Patients with Statin Side Effects: A Case Series.
    Drug Saf Case Rep 2017 Dec;4(1)
    Department of Medicine, University of California, San Diego, 9500 Gilman Drive #0995, La Jolla, CA, 92093-0995, USA.
    Physicians are among those prescribed statins and therefore, subject to potential statin adverse effects (AEs). There is little information on the impact of statin AEs on physicians affected by them. We sought to assess the character and impact of statin AEs occurring in physicians and retired physicians, and to ascertain whether/how personal experience of AEs moderated physicians' attitude toward statin use. Read More

    A study of bone turnover markers in gestational diabetes mellitus.
    Indian J Endocrinol Metab 2017 Jan-Feb;21(1):38-44
    Department of Gynaecology, J. N. Medical College and Hospital, Aligarh, Uttar Pradesh, India.
    Introduction: Gestational diabetes is defined as carbohydrate intolerance resulting in hyperglycemia of variable severity with the first recognition during pregnancy. Established risk factors for gestational diabetes mellitus (GDM) are maternal age, obesity, family history of diabetes, etc. Vitamin D, parathyroid hormone (PTH), and various other hormones are known for their function in maintaining calcium and phosphorous homeostatic. Read More

    Small heterodimer partner (SHP) contributes to insulin resistance in cardiomyocytes.
    Biochim Biophys Acta 2017 Feb 15. Epub 2017 Feb 15.
    Department of Molecular Genetics, CARIM School for Cardiovascular Diseases, Faculty of Health, Medicine and Life Sciences, Maastricht University, 6200 MD Maastricht, Netherlands. Electronic address:
    Small heterodimer partner (SHP) is an atypical nuclear receptor expressed in heart that has been shown to inhibit the hypertrophic response. Here, we assessed the role of SHP in cardiac metabolism and inflammation. Mice fed a high-fat diet (HFD) displayed glucose intolerance accompanied by increased cardiac mRNA levels of Shp. Read More

    An ATF4/ATG5 Signaling in Hypothalamic POMC Neurons Regulates Fat Mass via Affecting Energy Expenditure.
    Diabetes 2017 Feb 17. Epub 2017 Feb 17.
    Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institute for Biological Sciences, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China.
    Although many biological functions of activating transcription factor 4 (ATF4) have been identified, a role of hypothalamic ATF4 in the regulation of energy homeostasis is poorly understood. Here, we showed that hypothalamic pro-opiomelanocortin (POMC) neurons specific ATF4 knockout (PAKO) mice are lean and have higher energy expenditure. Furthermore, PAKO mice were resistant to high-fat diet (HFD)-induced obesity, glucose intolerance and leptin resistance. Read More

    Butein induction of HO-1 by p38 MAPK/Nrf2 pathway in adipocytes attenuates high-fat diet induced adipose hypertrophy in mice.
    Eur J Pharmacol 2017 Feb 14. Epub 2017 Feb 14.
    College of Pharmacy, Woosuk University, Wanju-gun, Jeollabuk-do, Republic of Korea. Electronic address:
    Adipose tissue inflammation and oxidative stress are key components in the development of obesity and insulin resistance. Heme oxygenase (HO)-1 in adipocytes protects against obesity and adipose dysfunction. In this study, we report the identification of butein, a flavonoid chalcone, as a novel inducer of HO-1 expression in adipocytes in vitro and in vivo. Read More

    Dipeptidyl peptidase-4 impairs insulin signaling and promotes lipid accumulation in hepatocytes.
    Biochem Biophys Res Commun 2017 Feb 16. Epub 2017 Feb 16.
    Christian Doppler Laboratory for Metabolic Crosstalk, Department of Internal Medicine I, Medical University Innsbruck, Innsbruck, Austria; Department of Internal Medicine I, Medical University Innsbruck, Innsbruck, Austria. Electronic address:
    Dipeptidyl-peptidase 4 [DPP-4) has evolved into an important target in diabetes therapy due to its role in incretin hormone metabolism. In contrast to its systemic effects, cellular functions of membranous DPP-4 are less clear. Here we studied the role of DPP-4 in hepatic energy metabolism. Read More

    Role of Nrf2 and protective effects of Metformin against tobacco smoke-induced cerebrovascular toxicity.
    Redox Biol 2017 Feb 12;12:58-69. Epub 2017 Feb 12.
    Department of Pharmaceutical Sciences, School of Pharmacy, Texas Tech University Health Sciences Center, 1300 S. Coulter Street, Amarillo, TX 79106, USA; Center for Blood Brain Barrier Research, Texas Tech University Health Sciences Center, Amarillo, TX 79106, USA. Electronic address:
    Cigarette smoking (CS) is associated with vascular endothelial dysfunction in a causative way primarily related to the TS content of reactive oxygen species (ROS), nicotine, and inflammation. TS promotes glucose intolerance and increases the risk of developing type-2 diabetes mellitus (2DM) with which it shares other pathogenic traits including the high risk of cerebrovascular and neurological disorders like stroke via ROS generation, inflammation, and blood-brain barrier (BBB) impairment. Herein we provide evidence of the role played by nuclear factor erythroid 2-related factor (Nrf2) in CS-induced cerebrobvascular/BBB impairments and how these cerebrovascular harmful effects can be circumvented by the use of metformin (MF; a widely prescribed, firstline anti-diabetic drug) treatment. Read More

    Awareness of Gestational Diabetes and its Risk Factors among Pregnant Women in Samoa.
    Hawaii J Med Public Health 2017 Feb;76(2):48-54
    Institute of Inflammation and Ageing, College of Medical and Dental Sciences, University of Birmingham, Edgbaston, Birmingham.
    Gestational diabetes mellitus (GDM) is a subtype of diabetes mellitus defined as the development, or first recognition, of glucose intolerance during pregnancy. The risk of developing type 2 diabetes mellitus (T2DM) is greater in mothers with GDM compared to the general population. Preventing the development of GDM could help lower the prevalence of T2DM and long-term morbidity in children of affected mothers. Read More

    An Exercise-Only Intervention in Obese Fathers  Restores Glucose and Insulin Regulation in  Conjunction with the Rescue of Pancreatic Islet Cell  Morphology and MicroRNA Expression in Male  Offspring.
    Nutrients 2017 Feb 9;9(2). Epub 2017 Feb 9.
    Discipline of Obstetrics and Gynaecology, School of Paediatrics and Reproductive Health, University of Adelaide, Adelaide 5005, Australia.
    Paternal obesity programs metabolic syndrome in offspring. Low-impact exercise in obese  males improves the metabolic health of female offspring, however whether this occurred in male  offspring remained unknown. C57BL/6NHsd (Harlan) mice were fed a control diet (CD; 6% fat, n =  7) or a high-fat diet (HFD; 21% fat, n = 16) for 18 weeks. Read More

    Physical activity prevents alterations in mitochondrial ultrastructure and glucometabolic parameters in a high-sugar diet model.
    PLoS One 2017 15;12(2):e0172103. Epub 2017 Feb 15.
    Laboratório de Bioquímica e Biologia Molecular, Núcleo de Pesquisas em Ciências Biológicas, Universidade Federal de Ouro Preto, Ouro Preto, Minas Gerais, Brasil.
    Endurance exercise is a remarkable intervention for the treatment of many diseases. Mitochondrial changes on skeletal muscle are likely important for many of the benefits provided by exercise. In this study, we aimed to evaluate the effects that a regular physical activity (swimming without workload) has on mitochondrial morphological alterations and glucometabolic parameters induced by a high-sugar diet (HSD). Read More

    Endoscopic Bariatric and Metabolic Therapies: New and Emerging Technologies.
    Gastroenterology 2017 Feb 9. Epub 2017 Feb 9.
    Division of Gastroenterology, Brigham and Women's Hospital.
    Endoscopic Bariatric and Metabolic Therapies (EBMT) are a new addition to the treatment arsenal for obesity. These include devices which are placed or removed via flexible endoscopy, and procedures which utilize instruments that require flexible endoscopy for the indications of weight loss or treatment of glucose intolerance (from pre-diabetes to diabetes). The EBMTs are generally divided into gastric and small bowel categories, and although individual EBMTs may have unique mechanisms of action, similar themes in proposed mechanism of action are seen in the gastric and small bowel EBMTs respectively. Read More

    Obesity alters the ovarian glucidic homeostasis disrupting the reproductive outcome of female rats.
    J Nutr Biochem 2017 Jan 23;42:194-202. Epub 2017 Jan 23.
    Laboratorio de Biología del Desarrollo, Instituto de Fisiología, Biología Molecular y Neurociencias (IFIBYNE-CONICET-UBA), Pabellón 2, Cdad. Universitaria, Buenos Aires, Argentina. Electronic address:
    Obesity constitutes a health problem of increasing worldwide prevalence related to many reproductive problems such as infertility, ovulation dysfunction, preterm delivery, fetal growth disorders, etc. The mechanisms linking obesity to these pathologies are not fully understood. Cafeteria diet (CAF) is the animal model used for the study of obesity that more closely reflects western diet habits. Read More

    Osteocalcin and its endocrine functions.
    Biochem Pharmacol 2017 Feb 9. Epub 2017 Feb 9.
    Laboratory of Molecular and Cellular Biochemistry and, Faculty of Dental Science, Kyushu University, Fukuoka 812-8582, Japan. Electronic address:
    Bone has traditionally been regarded as a static structural organ that supports movement of the body and protects the internal organs. However, evidence has been accumulated in the past decade showing that bone also functions as an endocrine organ that regulates systemic glucose and energy metabolism. Osteocalcin, an osteoblast-specific secreted protein, acts as a hormone by stimulating insulin production and increasing energy expenditure and insulin sensitivity in target organs. Read More

    Sarcolipin expression is not required for the mitochondrial enzymatic response to physical activity or diet.
    J Appl Physiol (1985) 2017 Feb 9:jap.00833.2016. Epub 2017 Feb 9.
    Waterloo University, Canada
    In mice, transgenic manipulation of Ca(2+)-handling proteins is sufficient to alter the metabolic phenotype of muscle. We have previously shown that ablation of sarcolipin (SLN), a regulatory protein and uncoupler of sarco(endo)plasmic reticulum Ca(2+)-ATPases, leads to excessive diet-induced obesity and glucose intolerance in mice. However, it is unclear how loss of SLN per se affects muscle oxidative capacity and the ability of mitochondria to adapt to physiological stimuli such as exercise training or calorie overload. Read More

    Regulation of the novel adipokines/ hepatokines fetuin A and fetuin B in gestational diabetes mellitus.
    Metabolism 2017 Mar 9;68:88-94. Epub 2016 Dec 9.
    University of Leipzig, Department of Endocrinology and Nephrology, 04103 Leipzig, Germany; Leipzig University Medical Center, IFB AdiposityDiseases, 04103 Leipzig, Germany. Electronic address:
    Objective: Fetuin B has recently been introduced as a novel adipokine/hepatokine which is significantly increased in hepatic steatosis and mediates impaired insulin action, as well as glucose intolerance. However, regulation of fetuin B in gestational diabetes mellitus (GDM), as well as its longitudinal changes in the peripartum period, have not been elucidated, so far.

    Design And Methods: Circulating fetuin A and fetuin B were quantified in 74 women with GDM and 74 healthy and gestational age-matched controls by enzyme-linked immunosorbent assay during pregnancy (median gestational age: 201days). Read More

    Genetic ablation of phosphatidylcholine transfer protein/StarD2 in ob/ob mice improves glucose tolerance without increasing energy expenditure.
    Metabolism 2017 Mar 1;68:145-149. Epub 2016 Dec 1.
    Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA, 02115, USA. Electronic address:
    Objective: Phosphatidylcholine transfer protein (PC-TP; synonym StarD2) is highly expressed in liver and oxidative tissues. PC-TP promotes hepatic glucose production during fasting and aggravates glucose intolerance in high fat fed mice. However, because PC-TP also suppresses thermogenesis in brown adipose tissue (BAT), its direct contribution to obesity-associated diabetes in mice remains unclear. Read More

    Tributyltin exposure at noncytotoxic doses dysregulates pancreatic β-cell function in vitro and in vivo.
    Arch Toxicol 2017 Feb 8. Epub 2017 Feb 8.
    Institute of Toxicology, College of Medicine, National Taiwan University, Taipei, Taiwan, Republic of China.
    Tributyltin (TBT) is an endocrine disruptor. TBT can be found in food and in human tissues and blood. Several animal studies revealed that organotins induced diabetes with decreased insulin secretion. Read More

    Kinase Suppressor of Ras 2 (KSR2) expression in the brain regulates energy balance and glucose homeostasis.
    Mol Metab 2017 Feb 18;6(2):194-205. Epub 2016 Dec 18.
    Eppley Institute for Research in Cancer and Allied Diseases, 985950 Nebraska Medical Center, University of Nebraska Medical Center, Omaha, NE 68198-5950, USA; Fred & Pamela Buffett Cancer Center, 987696 Nebraska Medical Center, University of Nebraska Medical Center, Omaha, NE 68198-7696, USA.
    Objective: Kinase Suppressor of Ras 2 (KSR2) is a molecular scaffold coordinating Raf/MEK/ERK signaling that is expressed at high levels in the brain. KSR2 disruption in humans and mice causes obesity and insulin resistance. Understanding the anatomical location and mechanism of KSR2 function should lead to a better understanding of physiological regulation over energy balance. Read More

    Obesity and pregnancy: mechanisms of short term and long term adverse consequences for mother and child.
    BMJ 2017 Feb 8;356:j1. Epub 2017 Feb 8.
    Arkansas Children's Nutrition Center, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.
    Obesity is the most common medical condition in women of reproductive age. Obesity during pregnancy has short term and long term adverse consequences for both mother and child. Obesity causes problems with infertility, and in early gestation it causes spontaneous pregnancy loss and congenital anomalies. Read More

    Exercise restores bioavailability of hydrogen sulfide and promotes autophagy influx in livers of mice fed with high-fat diet.
    Can J Physiol Pharmacol 2017 Jan 10. Epub 2017 Jan 10.
    Xi'an Technological University, Xi'an, Shaanxi, China ;
    In the gold standard treatment for non-alcoholic fatty liver disease (NAFLD), exercise training has been shown to effectively improve NASH. However, limited data are available about the underlying mechanisms involved. This work was undertaken to investigate the mechanisms underlying the beneficial effect of exercise training on high-fat diet (HFD)-induced NAFLD in mice. Read More

    Pancreatic impairment and Igf2 hypermethylation induced by developmental exposure to bisphenol A can be counteracted by maternal folate supplementation.
    J Appl Toxicol 2017 Feb 6. Epub 2017 Feb 6.
    Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People's Republic of China.
    Increasing evidence indicates that bisphenol A (BPA), a widely manufactured environmental pollutant, can induce changes in DNA methylation paatterns, which is a potential mechanism linking this environmental exposure to disease development. We investigated the influence of developmental exposure to BPA on pancreatic DNA methylation patterns and whether maternal folate supplementation can modify the epigenetic status and pancreatic impairment induced by BPA. Our results showed that maternal dietary folate supplementation in rats exposed to BPA counteracted the observed BPA-induced pancreatic impairments in the offspring, which included disrupted insulin secretion and glucose intolerance, and impaired morphology and ultrastructure of β cells. Read More

    Apolipoprotein CIII Overexpression-Induced Hypertriglyceridemia Increases Nonalcoholic Fatty Liver Disease in Association with Inflammation and Cell Death.
    Oxid Med Cell Longev 2017 10;2017:1838679. Epub 2017 Jan 10.
    Department of Structural and Functional Biology, Biology Institute, State University of Campinas, Campinas, SP, Brazil.
    Nonalcoholic fatty liver disease (NAFLD) is the principal manifestation of liver disease in obesity and metabolic syndrome. By comparing hypertriglyceridemic transgenic mice expressing apolipoprotein (apo) CIII with control nontransgenic (NTg) littermates, we demonstrated that overexpression of apoCIII, independent of a high-fat diet (HFD), produces NAFLD-like features, including increased liver lipid content; decreased antioxidant power; increased expression of TNFα, TNFα receptor, cleaved caspase-1, and interleukin-1β; decreased expression of adiponectin receptor-2; and increased cell death. This phenotype is aggravated and additional NAFLD features are differentially induced in apoCIII mice fed a HFD. Read More

    Effects of topical capsaicin combined with moderate exercise on insulin resistance, body weight and oxidative stress in hypoestrogenic obese rats.
    Int J Obes (Lond) 2017 Feb 6. Epub 2017 Feb 6.
    Pharmacobiology Department, Centro de Investigación y de Estudios Avanzados-Instituto Politécnico Nacional, Mexico City, Mexico.
    Background: Hypoestrogenic women are one of the most vulnerable groups for the development of obesity and its complications. Capsaicin and exercise have demonstrated to reduce body weight and to improve insulin sensitivity in different animal models, but it is unknown whether their combination could be useful in hypoestrogenic obese females.

    Methods: We investigated whether topical capsaicin, exercise or their combination had better therapeutic effects in an obesity-hypoestrogenism model. Read More

    Resistant maltodextrin or fructooligosaccharides promotes GLP-1 production in male rats fed a high-fat and high-sucrose diet, and partially reduces energy intake and adiposity.
    Eur J Nutr 2017 Feb 4. Epub 2017 Feb 4.
    Laboratory of Nutritional Biochemistry, Research Faculty of Agriculture, Hokkaido University, Kita-9, Nishi-9, Kita-ku, Sapporo, 060-8589, Japan.
    Purpose: Increasing secretion and production of glucagon-like peptide-1 (GLP-1) by continuous ingestion of certain food components has been expected to prevent glucose intolerance and obesity. In this study, we examined whether a physiological dose (5% weight in diet) of digestion-resistant maltodextrin (RMD) has a GLP-1-promoting effect in rats fed a high-fat and high-sucrose (HFS) diet.

    Methods: Rats were fed a control diet or the HFS (30% fat, 40% sucrose wt/wt) diet supplemented with 5% RMD or fructooligosaccharides (FOS) for 8 weeks or for 8 days in separated experiments. Read More

    Resveratrol improves exercise performance and skeletal muscle oxidative capacity in heart failure.
    Am J Physiol Heart Circ Physiol 2017 Feb 3:ajpheart.00455.2016. Epub 2017 Feb 3.
    University of Alberta
    We investigated whether treatment of mice with established pressure overload-induced heart failure (HF) with the naturally occurring polyphenol resveratrol could improve functional symptoms of clinical HF such as fatigue and exercise intolerance. C57Bl/6N mice were subjected to either sham or transverse aortic constriction surgery to induce HF. Three weeks post-surgery, a cohort of mice with established HF (% ejection fraction; %EF<45) was administered resveratrol (~450 mg/kg/d) or vehicle for 2 weeks. Read More

    Cardiovascular risk factors and glucose tolerance in midlife and risk of cognitive disorders in old age Up to a 49-year follow-up of the Helsinki Businessmen Study.
    Ann Med 2017 Feb 2:1-30. Epub 2017 Feb 2.
    e University of Helsinki, and Helsinki University Hospital , Helsinki , Finland.
    Purpose: To compare midlife predictors of old age dementia with or without concomitant atherosclerotic cardiovascular disease (ASCVD).

    Design: In the Helsinki Businessmen Study (men born in 1919-1934, n = 3309) death certificates (n = 1885) during up to 49-year follow-up (through December 31, 2013) were screened for dementia (n = 365) and ASCVD, and categorized as 1) AD without ASCVD ("pure" AD, n = 93), 2) AD+ASCVD (n = 126), 3) Vascular dementia (VD, n = 82), 4) Other or undefined etiology (n = 64). Using Cox analyses, death without dementia and dementia types were compared for prediction by midlife ASCVD risk factors. Read More

    Diabetes in Patients With Acromegaly.
    Curr Diab Rep 2017 Feb;17(2)
    Department of Endocrinology, Adelaide and Meath Hospitals incorporating the National Children's Hospital and Trinity College Dublin, Tallaght, Dublin 24, Ireland.
    Purpose Of Review: Acromegaly is a clinical syndrome which results from growth hormone excess. Uncontrolled acromegaly is associated with cardiovascular mortality, due to an excess of risk factors including diabetes mellitus, hypertension and cardiomegaly. Diabetes mellitus is a frequent complication of acromegaly with a prevalence of 12-37%. Read More

    Malabsorption, Orocecal Transit Time and Small Intestinal Bacterial Overgrowth in Type 2 Diabetic Patients: A Connection.
    Indian J Clin Biochem 2017 Mar 3;32(1):84-89. Epub 2016 May 3.
    0000 0004 1767 2903grid.415131.3Department of Gastroenterology, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, 160012 India.
    Type 2 diabetes mellitus consists of dysfunctions characterized by hyperglycemia and resulting from combination of resistance to insulin action and inadequate insulin secretion. Most of diabetic patients report significant gastrointestinal symptoms. Entire GI tract can be affected by diabetes from oral cavity to large bowel and anorectal region. Read More

    Regulation of hepatic pyruvate dehydrogenase phosphorylation in offspring glucose intolerance induced by intrauterine hyperglycemia.
    Oncotarget 2017 Jan 27. Epub 2017 Jan 27.
    International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200030, China.
    Aim: Gestational diabetes mellitus (GDM) has been shown to be associated with a high risk of diabetes in offspring. In mitochondria, the inhibition of pyruvate dehydrogenase (PDH) activity by PDH phosphorylation is involved in the development of diabetes. We aimed to determine the role of PDH phosphorylation in the liver in GDM-induced offspring glucose intolerance. Read More

    Compound K attenuates glucose intolerance and hepatic steatosis through AMPK-dependent pathways in type 2 diabetic OLETF rats.
    Korean J Intern Med 2017 Feb 1. Epub 2017 Feb 1.
    Department of Endocrinology and Metabolism, Kyung Hee University School of Medicine, Seoul, Korea.
    Background/aims: Non-alcoholic fatty liver disease is associated with insulin resistance. Compound K (CK) is the final metabolite of panaxadiol ginsenosides that have been shown to exert antidiabetic effects. However, the molecular mechanism of the antidiabetic effects in the liver have not been elucidated; further, whether CK has beneficial effects in hepatosteatosis remains unclear. Read More

    Pro-fibrotic infrapatellar fat pad remodeling without M1-macrophage polarization precedes knee osteoarthritis in diet-induced obese mice.
    Arthritis Rheumatol 2017 Jan 31. Epub 2017 Jan 31.
    Aging and Metabolism Research Program, Oklahoma Medical Research Foundation (OMRF), Oklahoma City, OK, USA, 73104.
    Objective: To test the hypothesis that high-fat (HF) diet-induced obesity increases pro-inflammatory cytokine expression, macrophage infiltration and M1 polarization in the infrapatellar fat pad (IFP) prior to knee cartilage degeneration.

    Methods: We characterized the effect of HF feeding on knee OA pathology, body adiposity, and glucose intolerance in male C57BL/6J mice and identified a diet duration that induces metabolic dysfunction prior to cartilage degeneration. Magnetic resonance imaging and histomorphology were used to quantify changes in epididymal, subcutaneous, and infrapatellar fat pads and adipocyte sizes. Read More

    Turning up the heat against metabolic syndrome and non-alcoholic fatty liver disease.
    Clin Sci (Lond) 2017 Feb;131(4):327-328
    Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of São Paulo, São Paulo 05508000, Brazil
    Brown adipose tissue (BAT), an organ specialized in the conversion of chemical energy from nutrients into heat through a process denominated as nonshivering thermogenesis, plays an important role in defence of body weight and homoeothermy in mammals. BAT nonshivering thermogenesis relies on the activity of the uncoupling protein 1 (UCP-1), a mitochondrial protein that, on demand, deviates proton gradient from ATP synthesis to heat generation. Energetically, this process is supported by BAT-elevated mitochondrial density and outstanding capacity to oxidize fatty acids and glucose. Read More

    A single non-synonymous NCOA5 variation in type 2 diabetic patients with hepatocellular carcinoma impairs the function of NCOA5 in cell cycle regulation.
    Cancer Lett 2017 Jan 27;391:152-161. Epub 2017 Jan 27.
    Department of Physiology, Michigan State University, East Lansing, MI, 48824, USA. Electronic address:
    Type 2 Diabetes (T2D) is a risk factor for hepatocellular carcinoma (HCC). We have previously described that haploinsufficiency of nuclear receptor coactivator 5 (NCOA5) is a genetic defect linking glucose intolerance to HCC. Here we report identification and characterization of a single nucleotide variation (T445A) in NCOA5, causing an amino acid Thr to Ala substitution, in adjacent non-tumorous liver tissues derived from patients with concurrent HCC and T2D. Read More

    Diagnosis of genetic predisposition for lactose intolerance by high resolution melting analysis.
    Ann Biol Clin (Paris) 2017 Feb;75(1):67-74
    Département de biologie, Hôpital d'Instruction des armées Bégin, Saint Mandé, France.
    Lactose, the principle sugar in milk, is a disaccharide hydrolyzed by intestinal lactase into glucose and galactose, which are absorbed directly by diffusion in the intestine. The decline of lactase expression (or hypolactasia) in intestinal microvilli after weaning is a normal phenomenon in mammals known as lactase deficiency. It is observed in nearly 75% of the world population and is an inherited autosomal recessive trait with incomplete penetrance. Read More

    5-aminolevulinic acid combined with ferrous ion reduces adiposity and improves glucose tolerance in diet-induced obese mice via enhancing mitochondrial function.
    BMC Pharmacol Toxicol 2017 Jan 30;18(1). Epub 2017 Jan 30.
    SBI Pharmaceuticals Co. Ltd., 1-6-1, Roppongi, Minato-ku, Tokyo, 106-6020, Japan.
    Background: Mitochondrial dysfunction is associated with obesity and various obesity-associated pathological conditions including glucose intolerance. 5-Aminolevulinic acid (ALA), a precursor of heme metabolites, is a natural amino acid synthesized in the mitochondria, and various types of cytochromes containing heme contribute to aerobic energy metabolism. Thus, ALA might have beneficial effects on the reduction of adiposity and improvement of glucose tolerance through its promotion of heme synthesis. Read More

    Liver-specific Prox1 inactivation causes hepatic injury and glucose intolerance in mice.
    FEBS Lett 2017 Jan 27. Epub 2017 Jan 27.
    Department of Clinical Application, Center for iPS cell Research and Application, Kyoto, Japan.
    Previous reports have revealed that Prospero-related homeobox 1 (Prox1) is required for the migration and differentiation of hepatoblasts during embryonic liver formation. However, the role of Prox1 in adults remains to be elucidated. We created liver-specific Prox1 knockout mice to verify the role of Prox1 in adult hepatocytes. Read More

    Re-evaluation of glycated hemoglobin and glycated albumin with continuous glucose monitoring system as markers of glycemia in patients with liver cirrhosis.
    Biomed Rep 2017 Jan 10;6(1):51-56. Epub 2016 Nov 10.
    Division of Metabolism and Endocrinology, Faculty of Medicine, Saga University, Saga 8498501, Japan.
    Liver cirrhosis (LC) is frequently accompanied by glucose intolerance. The present study was designed to determine whether glycated hemoglobin A1c (HbA1c) and glycated albumin (GA) were predictive markers of glycemia, as determined by a continuous glucose monitoring system (CGMS), in patients with LC. A total of 30 patients with LC, including 3, 19, 5, 2 and 1 with LC due to hepatitis B virus, hepatitis C virus, non-alcoholic steatohepatitis, alcohol and unknown causes, respectively, were assessed by CGMS. Read More

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