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    15859 results match your criteria Glucose Intolerance

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    Loss of ovarian function in association with a high-fat diet promotes insulin resistance and disturbs adipose tissue immune homeostasis.
    J Nutr Biochem 2018 Mar 20;57:93-102. Epub 2018 Mar 20.
    Nutritional Immunology Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA.
    Loss of ovarian function, as occurs in menopause or after ovariectomy (OVX), is associated with insulin resistance. Adipose tissue inflammation is suggested to be a key component of obesity-induced insulin resistance in male rodents. However, little is known about the effect of OVX and diet on insulin resistance in association with immune homeostasis. Read More

    Qing brick tea (QBT) aqueous extract protects monosodium glutamate-induced obese mice against metabolic syndrome and involves up-regulation Transcription Factor Nuclear Factor-Erythroid 2-Related Factor 2 (Nrf2) antioxidant pathway.
    Biomed Pharmacother 2018 Apr 18;103:637-644. Epub 2018 Apr 18.
    Department of Pharmacy, The First College of Clinical Medical Science, China Three Gorges University & Yichang Central People's Hospital, Yichang, 443000, China. Electronic address:
    Background: Qing brick tea (QBT), traditional and popular beverage for Chinese people, is an important post-fermentation dark tea. Our present study was performed to investigate the ameliorative effects of QBT aqueous extract on metabolic syndrome (Mets) in monosodium glutamate-induced obese mice and the potential mechanisms.

    Method: Monosodium glutamate-induced obese mice were used to evaluate the anti-Mets effects of QBT. Read More

    Dihydrocapsiate supplementation prevented high-fat diet-induced adiposity, hepatic steatosis, glucose intolerance, and gut morphological alterations in mice.
    Nutr Res 2018 Mar 5;51:40-56. Epub 2017 Dec 5.
    National Agri-Food Biotechnology Institute (NABI), SAS Nagar, Punjab, India 160071. Electronic address:
    Despite the lipolytic and thermogenic properties of capsaicin, its putative use as a weight-lowering dietary supplement has been limited because of the burning sensation caused by capsaicin when it comes in contact with mucous membranes. A potential alternative to capsaicin are the capsinoids, nonpungent capsaicin analogs that exhibit effects similar to capsaicin. Whereas the antiobesity properties of capsinoids have been reported, the effectiveness of FDA-approved synthetic dihydrocapsiate has not yet been investigated. Read More

    Lixisenatide, a novel GLP-1 analog, protects against cerebral ischemia/reperfusion injury in diabetic rats.
    Naunyn Schmiedebergs Arch Pharmacol 2018 Apr 18. Epub 2018 Apr 18.
    Department of Pharmacology and Toxicology, Faculty of Pharmacy, Minia University, El-Minia, 61111, Egypt.
    Type 2 diabetes mellitus (T2DM) is a major risk factor for ischemic stroke accompanied by vascular dysfunction and poor cerebrovascular outcome. Lixisenatide is a glucagon like peptide-1 (GLP-1) analog that is recently used for T2DM treatment with established neuroprotective properties. This study investigated and compared the neuroprotective effect of lixisenatide against glimepiride on diabetic rats subjected to global cerebral ischemia/reperfusion (I/R) injury. Read More

    Exploring the extent and scope of epigenetic inheritance.
    Nat Rev Endocrinol 2018 Apr 17. Epub 2018 Apr 17.
    Department of Paediatrics, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK.
    Environmental factors, particularly during early life, are important for the later metabolic health of the individual. In our obesogenic environment, it is of major socio-economic importance to investigate the mechanisms that contribute to the risk of metabolic ill health. Increasing evidence from a variety of model organisms suggests that non-genetically determined phenotypes, including metabolic effects such as glucose intolerance and obesity, can be passed between generations, which encourages us to revisit heredity. Read More

    Phenylmethimazole abrogates diet-induced inflammation, glucose intolerance and NAFLD.
    J Endocrinol 2018 Apr 17. Epub 2018 Apr 17.
    K McCall, Specialty Medicine, Ohio University, Athens, United States
    Nonalcoholic fatty liver disease (NAFLD) is the hepatic manifestation of both metabolic and inflammatory diseases and has become the leading chronic liver disease worldwide. High fat (HF) diets promote an increased uptake and storage of free fatty acids (FFAs) and triglycerides (TGs) in hepatocytes, which initiates steatosis and induces lipotoxicity, inflammation, and insulin resistance. Activation and signaling of Toll-like receptor 4 (TLR4) by FFAs induces inflammation evident in NAFLD and insulin resistance. Read More

    Exposure to concentrated ambient PM alters the composition of gut microbiota in a murine model.
    Part Fibre Toxicol 2018 Apr 17;15(1):17. Epub 2018 Apr 17.
    Department of Environmental Health, School of Public Health, Fudan University, 130 Dong'an Rd, Shanghai, 200032, China.
    Background: Exposure to ambient fine particulate matter (PM) correlates with abnormal glucose homeostasis, but the underlying biological mechanism has not been fully understood. The gut microbiota is an emerging crucial player in the homeostatic regulation of glucose metabolism. Few studies have investigated its role in the PM exposure-induced abnormalities in glucose homeostasis. Read More

    Perspective: Cardiovascular Responses to Sugar-Sweetened Beverages in Humans: A Narrative Review with Potential Hemodynamic Mechanisms.
    Adv Nutr 2018 Mar;9(2):70-77
    Department of Medicine/Physiology, University of Fribourg, Fribourg, Switzerland.
    Cardiovascular diseases are still the primary cause of mortality worldwide, with high blood pressure and type 2 diabetes as major promoters. Over the past 3 decades, almost in parallel with the rise in cardiovascular disease incidence, the consumption of sugar-sweetened beverages (SSBs) has increased. In this context, SSBs are potential contributors to weight gain and increase the risk for elevations in blood pressure, type 2 diabetes, coronary heart disease, and stroke. Read More

    Can Substitute in Cereal Dough Leavening?
    Foods 2018 Apr 16;7(4). Epub 2018 Apr 16.
    Dipartimento di Scienze per gli Alimenti, la Nutrizione, l'Ambiente, Università degli Studi di Milano, 20133 Milan, Italy.
    Baker’s yeast intolerance is rising among Western populations, where is spread in fermented food and food components. is a bacterium commonly used in tropical areas to produce alcoholic beverages, and it has only rarely been considered for dough leavening probably because it only ferments glucose, fructose and sucrose, which are scarcely present in flour. However, through alcoholic fermentation, similarly to , it provides an equimolar mixture of ethanol and CO₂ that can rise a dough. Read More

    Novel role of GLP-1 receptor signaling in energy expenditure during chronic high fat diet feeding in rats.
    Physiol Behav 2018 Apr 11. Epub 2018 Apr 11.
    Physiology and Behavior Laboratory, ETH Zurich, Schwerzenbach, Switzerland. Electronic address:
    Objective: Glucagon-like peptide-1 (GLP-1) secreted from intestinal L-cells plays a major role in meal termination and glucose-dependent insulin secretion. Several lines of evidence indicate, however, that the acute satiating and incretin effects of GLP-1 are attenuated with high fat diet (HFD) exposure. Here we tested the hypothesis that endogenous GLP-1 differentially affects energy balance and glucose homeostasis dependent on whether rats are fed chow or HFD (60% energy from fat). Read More

    Deletion of the insulin receptor in sensory neurons increases pancreatic insulin levels.
    Exp Neurol 2018 Apr 9;305:97-107. Epub 2018 Apr 9.
    Department of Anatomy and Cell Biology, University of Kansas Medical Center, United States. Electronic address:
    Insulin is known to have neurotrophic properties and loss of insulin support to sensory neurons may contribute to peripheral diabetic neuropathy (PDN). Here, genetically-modified mice were generated in which peripheral sensory neurons lacked the insulin receptor (SNIRKO mice) to determine whether disrupted sensory neuron insulin signaling plays a crucial role in the development of PDN and whether SNIRKO mice develop symptoms of PDN due to reduced insulin neurotrophic support. Our results revealed that SNIRKO mice were euglycemic and never displayed significant changes in a wide range of sensorimotor behaviors, nerve conduction velocity or intraepidermal nerve fiber density. Read More

    Cardiac Autonomic Neuropathy as a Result of Mild Hypercaloric Challenge in Absence of Signs of Diabetes: Modulation by Antidiabetic Drugs.
    Oxid Med Cell Longev 2018 31;2018:9389784. Epub 2018 Jan 31.
    Department of Pharmacology and Toxicology, Faculty of Medicine, The American University of Beirut, Beirut, Lebanon.
    Cardiac autonomic neuropathy (CAN) is an early cardiovascular complication of diabetes occurring before metabolic derangement is evident. The cause of CAN remains elusive and cannot be directly linked to hyperglycemia. Recent clinical data report cardioprotective effects of some antidiabetic drugs independent of their hypoglycemic action. Read More

    Measurement of breath acetone in patients referred for an oral glucose tolerance test.
    J Breath Res 2018 Apr 12. Epub 2018 Apr 12.
    Department of Pathology, Medway Maritime Hospital, Gillingham, Kent, UNITED KINGDOM OF GREAT BRITAIN AND NORTHERN IRELAND.
    Breath acetone concentrations were measured in 141 subjects (aged 19-91 yrs, mean=59.11yrs standard deviation=12.99yrs), male and female, undergoing an oral glucose tolerance test (OGTT), having been referred to clinic on suspicion of type 2 diabetes. Read More

    Chronic AT1 blockade improves glucose homeostasis in obese OLETF rats.
    J Endocrinol 2018 Apr 11. Epub 2018 Apr 11.
    R Ortiz, School of Natural Sciences, University of California Merced, Merced, United States.
    Obesity is associated with the inappropriate activation of the renin-angiotensin-system (RAS), which increases arterial pressure, impairs insulin secretion, and decreases peripheral tissue insulin sensitivity. RAS blockade reverses these detriments; however, it is not clear whether the disease state of the organism and treatment duration determine the beneficial effects of RAS inhibition on insulin secretion and insulin sensitivity. Therefore, the objective of this study was to compare the benefits of acute vs. Read More

    Evaluation of postprandial hypoglycemia in patients with nonalcoholic fatty liver disease by oral glucose tolerance testing and continuous glucose monitoring.
    Eur J Gastroenterol Hepatol 2018 Apr 9. Epub 2018 Apr 9.
    Department of Gastroenterology and Hepatology, Kochi Medical School, Kochi.
    Objective: Nonalcoholic fatty liver disease (NAFLD) is often associated with insulin resistance and glucose intolerance. Postprandial hypoglycemia frequently occurs in NAFLD patients; however, the details remain unclear.

    Patients And Methods: The 75-g oral glucose tolerance test (75gOGTT) in 502 patients with biopsy-proven NAFLD and continuous glucose monitoring (CGM) in 20 patients were performed, and the characteristics and causes of postprandial hypoglycemia were investigated. Read More

    [Long-term dietary nitrite and nitrate deficiency causes metabolic syndrome, endothelial dysfunction, and cardiovascular death in mice].
    Nihon Yakurigaku Zasshi 2018 ;151(4):148-154
    Department of Pharmacology, Graduate School of Medicine, University of the Ryukyus.
    Nitric oxide (NO) is synthesized not only from L-arginine by NO synthases (NOSs), but also from its inert metabolites, nitrite and nitrate. Green leafy vegetables are abundant in nitrate, however whether or not a deficiency in dietary nitrite/nitrate spontaneously causes disease remains to be clarified. In this study, we tested our hypothesis that long-term dietary nitrite/nitrate deficiency induces metabolic syndrome (MetS) in mice. Read More

    Metabolite changes in risk of type 2 diabetes mellitus in cohort studies: A systematic review and meta-analysis.
    Diabetes Res Clin Pract 2018 Apr 4;140:216-227. Epub 2018 Apr 4.
    College of Pharmacy, Research Institute of Pharmaceutical Sciences, Kyungpook National University, Daegu, Republic of Korea. Electronic address:
    Aims: Fasting plasma glucose, oral glucose tolerance test, and glycated hemoglobin are diagnostic markers for type 2 diabetes mellitus (T2DM). However, it is necessary to detect physiological changes in T2DM rapidly and stratify diabetic stage using other biomarkers. We performed a systematic review and meta-analysis to contribute to the development of objective and sensitive diagnostic indicators by integrating metabolite biomarkers derived from large-scale cohort studies. Read More

    Substance P preserves pancreatic β-cells in type 1 and type 2 diabetic mice.
    Biochem Biophys Res Commun 2018 May 9;499(4):960-966. Epub 2018 Apr 9.
    Department of Biomedical Science and Technology, Graduate School, Kyung Hee University, Seoul 02447, South Korea; East-West Medical Research Institute, Kyung Hee University, Seoul 02447, South Korea; College of Medicine, Kyung Hee University, Seoul 02447, South Korea; Kyung Hee University Medical Center, Seoul 02447, South Korea. Electronic address:
    Preservation of pancreatic β-cells is required for the development of therapies for type 1 and type 2 diabetes (T1D and T2D, respectively). Our previous study demonstrated that substance P (SP) preserves β-cell populations in mice with streptozotocin-induced T1D. Here, we demonstrated that chronic systemic treatment with SP restored the mass of β-cells both in nonobese diabetic (NOD) mice with T1D or db/db mice with T2D. Read More

    Sleep disorders in a sample of students in Taif University, Saudi Arabia: The role of obesity, insulin resistance, anemia and high altitude.
    Diabetes Metab Syndr 2018 Mar 27. Epub 2018 Mar 27.
    Pharm D, College of Pharmacy, Taif University, Taif, Saudi Arabia.
    Aim: The aim of this study was to assess the incidence of sleep disorders and excessive daytime sleepiness (EDS) among Taif University students and to explore the precipitating factors of these disorders.

    Methods: This study was carried out on 1066 students in Taif University of both sexes aging from 18 to 25 years. All included individuals were subjected to full history taking and thorough clinical examination, with special concern on anthropometric measurements (weight, height, waist-to-hip ratio and body mass index). Read More

    Carnosic acid protects mice from high-fat diet-induced NAFLD by regulating MARCKS.
    Int J Mol Med 2018 Mar 27. Epub 2018 Mar 27.
    Department of Endocrinology, Huai'an First People's Hospital, Nanjing Medical University, Huai'an, Jiangsu 223300, P.R. China.
    Non-alcoholic fatty liver disease (NAFLD) comprises a spectrum of liver damage characterized by abnormal hepatic fat accumulation and inflammatory response. Although the molecular mechanisms responsible for the disease are not yet fully understood, the pathogenesis of NAFLD likely involves multiple signals. The identification of effective therapeutic strategies to target these signals is of utmost importance. Read More

    Early Use of Etanercept for Graft-Versus-Host Disease After Liver Transplant: the Importance of Broad Spectrum Infective Prophylaxis.
    Exp Clin Transplant 2018 Apr 4. Epub 2018 Apr 4.
    From the UOC Anesthesia and Intensive Care Unit, Department of Medicine-DIMED, Padua Hospital, Padua, Italy.
    Graft-versus-host-disease after orthotopic liver transplant is a rare and life-threatening complication. The diagnosis is challenging and usually confirmed by chimerism and skin biopsies. The most common cause of death is sepsis (60%), and broad-spectrum antibiotics and antifungal prophylaxis are strongly recommended. Read More

    The Role of Intestinal C-type Regenerating Islet Derived-3 Lectins for Nonalcoholic Steatohepatitis.
    Hepatol Commun 2018 Apr 28;2(4):393-406. Epub 2018 Feb 28.
    Department of MedicineUniversity of California San DiegoLa JollaCA.
    C-type regenerating islet derived-3 (Reg3) lectins defend against pathogens and keep commensal bacteria at a distance. Deficiency of and facilitates alcohol-induced bacterial translocation and alcoholic liver disease. Intestinal is down-regulated in animal models of diet-induced obesity, but the functional consequences for nonalcoholic steatohepatitis (NASH) are unknown. Read More

    Peripheral CB1 Receptor Neutral Antagonist, AM6545, Ameliorates Hypometabolic Obesity and Improves Adipokine Secretion in Monosodium Glutamate Induced Obese Mice.
    Front Pharmacol 2018 20;9:156. Epub 2018 Mar 20.
    Department of Pharmacy, The Second Hospital of Jilin University, Changchun, China.
    Effect of peripheral cannabinoid receptor 1 (CB1R) blockade by AM6545 in the monosodium glutamate (MSG)-induced hypometabolic and hypothalamic obesity was observed, and the impact on intraperitoneal adipose tissue and adipokines was investigated. The MSG mice is characterized by excessive abdominal obesity, and combined with dyslipidemia and insulin resistance. 3-Week AM6545 treatment dose-dependently decreased the body weight, intraperitoneal fat mass, and rectified the accompanied dyslipidemia include elevated serum triglyceride, total cholesterol, free fatty acids, and lowered LDLc level. Read More

    A high nutrient dense diet alters hypothalamic gene expressions to influence energy intake in pigs born with low birth weight.
    Sci Rep 2018 Apr 3;8(1):5514. Epub 2018 Apr 3.
    State Key Laboratory of Animal Nutrition, Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing, 100193, P. R. China.
    The low birth weight (LBW) individual had greater risk of developing metabolic dysfunction in adulthood. The aim of this study was to test whether the LBW individual is more prone to glucose intolerance on a high nutrient dense (HND) diet, and to investigate the associated hypothalamic gene expressions using pigs as model. The intake of digestible energy intake, if calculated on a body weight basis, was greater in LBW pigs than that of normal birth weight (NBW) pigs. Read More

    Interleukin-10 as a novel biomarker of metabolic risk factors.
    Diabetes Metab Syndr 2018 Mar 27. Epub 2018 Mar 27.
    Department of Physiology, King George's Medical University, Lucknow, India.
    Background: Interleukin-10 (IL-10) is an adipocytokine that is abundantly expressed in visceral fat tissue. We investigated the association of interleukin-10 with the number of metabolic risk factors.

    Finding: The study population comprised 220 children who underwent annual health checkups. Read More

    Maternal lipopolysaccharide exposure results in glucose metabolism disorders and sex hormone imbalance in male offspring.
    Mol Cell Endocrinol 2018 Apr 1. Epub 2018 Apr 1.
    Anhui Provincial Key Laboratory of Population Health & Aristogenics, Hefei, 230032, China; Department of Toxicology, Anhui Medical University, Hefei, 230032, China.
    An adverse intrauterine environment may be an important factor contributing to the development of type 2 diabetes in later life. The present study investigated the longitudinal effects of maternal lipopolysaccharide (LPS) exposure during the third trimester on glucose metabolism and sex hormone balance in the offspring. Pregnant mice were intraperitoneally injected with LPS (50 μg/kg) daily from gestational day (GD) 15 to GD17. Read More

    Fetuin-B links nonalcoholic fatty liver disease to type 2 diabetes via inducing insulin resistance: Association and path analyses.
    Cytokine 2018 Mar 30;108:145-150. Epub 2018 Mar 30.
    Xiamen Diabetes Institute, The First Affiliated Hospital, Xiamen University, Xiamen, China; Department of Endocrinology and Diabetes, The First Affiliated Hospital, Xiamen University, Xiamen, China. Electronic address:
    Objective: Laboratory models suggested that Fetuin-B impaired insulin action in myotubes and hepatocytes and caused glucose intolerance in mice. We aimed to explore the independent associations and pathways among serum Fetuin-B, nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes (T2D).

    Methods: A cross-sectional study of 1318 obese adults who underwent serum Fetuin-B test and hepatic ultrasonography scanning was conducted in Xiamen, China. Read More

    Ethnic differences in antepartum glucose values that predict postpartum dysglycemia and neonatal macrosomia.
    Diabetes Res Clin Pract 2018 Mar 31;140:81-87. Epub 2018 Mar 31.
    Division of Endocrinology and Metabolism, Department of Medicine, 9th Floor, Clinical Sciences Building, University of Alberta, Edmonton, Alberta T6G 2G3, Canada.
    Background And Objective: Gestational diabetes (GDM) occurs more often in women from certain ethnic groups and is also associated with fetal macrosomia. In this study, we investigated the ability of a gestational diabetes screening test (GDS), the 2 h 75 g-Oral Glucose Tolerance Test (OGTT), and glycated hemoglobin (HbA1c) in predicting postpartum dysglycemia and fetal macrosomia in women of Caucasian, Filipino, Chinese and South-Asian descent.

    Methods: 848 women diagnosed with carbohydrate intolerance in pregnancy who completed a 2 h 75 g- OGTT within 6 months postpartum, were included in the study. Read More

    Improvement of functional properties of a thermostable β-glycosidase for milk lactose hydrolysis.
    Biopolymers 2018 Apr 2:e23118. Epub 2018 Apr 2.
    Institute of Protein Biochemistry-Consiglio Nazionale delle Ricerche (CNR), via P. Castellino 111, Naples, 80131, Italy.
    In this work, a new exploitation of the thermostable β-glycosidase from Sulfolobus solfataricus expressed in Saccharomyces cerevisiae to create functional foods for low lactose diets was evaluated. For this purpose, the lactose hydrolysis reaction using immobilized and soluble enzymes was investigated. Activity and stability at different conditions of pH and temperature were tested. Read More

    Lower Concentrations of Circulating Medium and Long Chain Acylcarnitines Characterize Insulin Resistance in Persons with HIV.
    AIDS Res Hum Retroviruses 2018 Apr 1. Epub 2018 Apr 1.
    Vanderbilt University, Division of Infectious Diseases , Vanderbilt University Medical Center , A2200-MCN , 1161 21st Avenue South , Nashville, Tennessee, United States , 37232 ;
    In HIV-negative individuals, a plasma metabolite profile characterized by higher levels of branched-chain amino acids (BCAA), aromatic amino acids, and C3/C5 acylcarnitines is associated with insulin resistance and increased risk of diabetes. We sought to characterize the metabolite profile accompanying insulin resistance in HIV-positive persons to assess whether the same or different bioenergetics pathways might be implicated. We performed an observational cohort study of 70 non-diabetic, HIV-positive individuals (50% with body mass index ≥ 30 kg/m2) on efavirenz, tenofovir, and emtricitabine with suppressed HIV-1 RNA levels (< 50 copies/mL) for at least 2 years and a CD4+ count over 350 cells/µL. Read More

    Melatonin improves insulin resistance and hepatic steatosis through attenuation of alpha-2-HS-glycoprotein.
    J Pineal Res 2018 Apr 1:e12493. Epub 2018 Apr 1.
    Division of Endocrinology and Metabolism, Department of Internal Medicine, Korea University College of Medicine, Ansan, Korea.
    Melatonin plays an important role in regulating circadian rhythms. It also acts as a potent antioxidant and regulates glucose and lipid metabolism, although the exact action mechanism is not clear. The α2-HS-glycoprotein gene (AHSG) and its protein, fetuin-A (FETUA), are one of the hepatokines and are known to be associated with insulin resistance and type 2 diabetes. Read More

    Dehydroepiandrosterone supplementation is not beneficial in the late postmenopausal period in diet-induced obese rats.
    Life Sci 2018 Mar 27. Epub 2018 Mar 27.
    Department of Physiology and Biophysics, Institute of Biomedical Science, University of Sao Paulo, 1524 Prof. Lineu Prestes Ave., ICB 1, Sao Paulo 05508-900, SP, Brazil. Electronic address:
    Aims: Dehydroepiandrosterone (DHEA) is an adrenal steroid hormone that is a precursor of sexual hormones. It is reduced during aging and is strongly associated with insulin resistance and obesity. There is evidence for beneficial effects of this steroid, in both human and animal models, during perimenopause. Read More

    Chronic noise-exposure exacerbates insulin resistance and promotes the manifestations of the type 2 diabetes in a high-fat diet mouse model.
    PLoS One 2018 30;13(3):e0195411. Epub 2018 Mar 30.
    School of Human Communication Disorder, Dalhousie University, Halifax, Nova Scotia, Canada.
    Epidemiological studies have revealed that noise exposure was associated with an increased risk of type 2 diabetes mellitus (T2DM). However, the exact nature of that association remains to be elucidated. The present study is designed to examine the effects of chronic noise exposure on the development of T2DM in combination with a high-fat-diet (HFD) in mice. Read More

    Postpartum risk of diabetes and predictive factors for glucose intolerance in East Asian women with gestational diabetes.
    Diabetes Res Clin Pract 2018 Mar 26;140:1-8. Epub 2018 Mar 26.
    Department of Clinical Cell Biology and Medicine, Chiba University Graduate School of Medicine, Chiba, Japan; Division of Metabolism and Endocrinology, Chiba University Hospital, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, Japan.
    Aims: Women with a history of gestational diabetes mellitus (GDM) are likely to develop postpartum diabetes mellitus (DM). We examined women in the early stages of pregnancy who were at high risk of postpartum DM progression to establish a follow-up method for early detection.

    Methods: We performed the oral glucose tolerance test (OGTT) and identified predictive factors for postpartum impaired glucose tolerance (IGT) or DM in 77 women after GDM, for 2 years after delivery, retrospectively. Read More

    Autonomic Neuropathy-a Prospective Cohort Study of Symptoms and / Ratio in Normal Glucose Tolerance, Impaired Glucose Tolerance, and Type 2 Diabetes.
    Front Neurol 2018 14;9:154. Epub 2018 Mar 14.
    Hand Surgery, Department of Translational Medicine, Lund University, Skåne University Hospital, Malmö, Sweden.
    Background: Autonomic neuropathy in diabetes, in addition to causing a range of symptoms originating from the autonomic nervous system, may increase cardiovascular morbidity. Our aim was to study the progression of autonomic neuropathy, based on symptom score and evaluation of an autonomic test, in persons with normal and impaired glucose tolerance and in patients with type 2 diabetes (T2D).

    Methods: Participants were recruited in 2003/2004 with a follow-up in 2014. Read More

    Association of Oxytocin with Glucose Intolerance and Inflammation Biomarkers in Metabolic Syndrome Patients with and without Prediabetes.
    Rev Diabet Stud 2018 10;14(4):364-371. Epub 2018 Mar 10.
    School of Pharmacy and Medicine, the University of Jordan, Amman, Jordan.
    Objectives: The aim of this study was to explore the differences in OXT levels in metabolic syndrome (MetS) subjects, newly diagnosed type 2 diabetes mellitus (T2D), and prediabetes subjects vs. MetS subjects without glucose intolerance (non-diabetic MetS). It was also intended to determine the relationship between plasma OXT levels and inflammatory markers in those subjects. Read More

    Cardiovascular and Metabolic Heterogeneity of Obesity: Clinical Challenges and Implications for Management.
    Circulation 2018 Mar;137(13):1391-1406
    Québec Heart and Lung Institute, Université Laval, Canada (P.P., J.-P.D.).
    The prevalence of obesity has increased globally over the last 2 decades. Although the body mass index has been a convenient and simple index of obesity at the population level, studies have shown that obesity defined by body mass index alone is a remarkably heterogeneous condition with varying cardiovascular and metabolic manifestations across individuals. Adipose tissue is an exquisitely active metabolic organ engaged in cross-talk between various systems; perturbation of adipose tissue results in a pathological response to positive caloric balance in susceptible individuals that directly and indirectly contributes to cardiovascular and metabolic disease. Read More

    AICAR Prevents Acute Olanzapine-Induced Disturbances in Glucose Homeostasis.
    J Pharmacol Exp Ther 2018 Mar 26. Epub 2018 Mar 26.
    University of Guelph
    Olanzapine (OLZ) is an antipsychotic drug used in the treatment of schizophrenia. While effective in reducing psychoses, OLZ causes acute increases in blood glucose. The acute effects of OLZ on hyperglycaemia are likely caused by reductions in insulin secretion, insulin resistance and increased hepatic glucose production. Read More

    Metformin reduces glucose intolerance caused by rapamycin treatment in genetically heterogeneous female mice.
    Aging (Albany NY) 2018 Mar 22. Epub 2018 Mar 22.
    Geriatric Research, Education and Clinical Center, South Texas Veterans Health Care System, San Antonio, TX 78294, USA.
    The use of rapamycin to extend lifespan and delay age-related disease in mice is well-established despite its potential to impair glucose metabolism which is driven partially due to increased hepatic gluconeogenesis. We tested whether a combination therapeutic approach using rapamycin and metformin could diminish some of the known metabolic defects caused by rapamycin treatment in mice. In genetically heterogeneous HET3 mice, we found that chronic administration of encapsulated rapamycin by diet caused a measurable defect in glucose metabolism in both male and female mice as early as 1 month after treatment. Read More

    Rapeseed oil fortified with micronutrients can reduce glucose intolerance during a high fat challenge in rats.
    Nutr Metab (Lond) 2018 20;15:22. Epub 2018 Mar 20.
    1INRA, UNH, Unité de Nutrition Humaine, CRNH Auvergne, Université Clermont Auvergne, 58 rue Montalembert - BP 321, F-63000 Clermont-Ferrand, France.
    Background: Better choices of dietary lipid sources and substitution of refined by fortified oils could reduce the intake of saturated fatty acids (FA) and increase the intake of omega 3 FA concomitantly to healthy bioactive compounds.

    Methods: The development of obesity and metabolic disturbances was explored in rats fed during 11 weeks with a high fat diet (HFD) in which the amount of saturated and polyunsaturated FA was respectively reduced and increased, using rapeseed oil as lipid source. This oil was used in a refined form (R) or fortified (10 fold increase in concentration) with endogenous micronutrients (coenzyme Q10 + tocopherol only (RF) only and also with canolol (RFC)). Read More

    Zinc and Insulin Resistance: Biochemical and Molecular Aspects.
    Biol Trace Elem Res 2018 Mar 21. Epub 2018 Mar 21.
    Department of Nutrition, Federal University of Piauí, Ministro Petrônio Portella Campus, Ininga, Teresina, Piauí, Brazil.
    Studies have shown the participation of minerals in mechanisms involved in the pathogenesis of insulin resistance. Zinc, in particular, seems to play an important role in the secretion and action of this hormone. Therefore, the aim of this review is to understand the role of zinc in increasing insulin sensitivity. Read More

    Increase in hepatic and decrease in peripheral insulin clearance characterize abnormal temporal patterns of serum insulin in diabetic subjects.
    NPJ Syst Biol Appl 2018 14;4:14. Epub 2018 Mar 14.
    1Department of Biological Sciences, Graduate School of Science, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033 Japan.
    Insulin plays a central role in glucose homeostasis, and impairment of insulin action causes glucose intolerance and leads to type 2 diabetes mellitus (T2DM). A decrease in the transient peak and sustained increase of circulating insulin following an infusion of glucose accompany T2DM pathogenesis. However, the mechanism underlying this abnormal temporal pattern of circulating insulin concentration remains unknown. Read More

    AIBP protects against metabolic abnormalities and atherosclerosis.
    J Lipid Res 2018 Mar 20. Epub 2018 Mar 20.
    UCSD, United States;
    Apolipoprotein A-I Binding Protein (AIBP) has been shown to augment cholesterol efflux from endothelial cells and macrophages. In zebrafish and mice, AIBP-mediated regulation of cholesterol levels in the plasma membrane of endothelial cells controls angiogenesis. The goal of this work was to evaluate metabolic changes and atherosclerosis in AIBP loss-of-function and gain-of-function animal studies. Read More

    Vascular Senescence in Cardiovascular and Metabolic Diseases.
    Front Cardiovasc Med 2018 5;5:18. Epub 2018 Mar 5.
    Department of Cardiovascular Biology and Medicine, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.
    In mammals, aging is associated with accumulation of senescent cells. Stresses such as telomere shortening and reactive oxygen species induce "cellular senescence", which is characterized by growth arrest and alteration of the gene expression profile. Chronological aging is associated with development of age-related diseases, including heart failure, diabetes, and atherosclerotic disease, and studies have shown that accumulation of senescent cells has a causative role in the pathology of these age-related disorders. Read More

    Specific situations.
    • Authors:
    Anaesth Crit Care Pain Med 2018 Mar 16. Epub 2018 Mar 16.
    Ambulatory surgery can be carried out in diabetic patients. By using a strict organisational and technical approach, the risk of glycaemic imbalance is minimised, allowing the patients to return to their previous way of life more quickly. Taking into account the context of ambulatory surgery, with a same day discharge, the aims are to minimise the changes to antidiabetic treatment, to maintain adequate blood sugar control and to resume oral feeding as quickly as possible. Read More

    Large Yellow Tea Attenuates Macrophage-Related Chronic Inflammation and Metabolic Syndrome in High-Fat Diet Treated Mice.
    J Agric Food Chem 2018 Apr 10;66(15):3823-3832. Epub 2018 Apr 10.
    Department of Food Science , Rutgers University , 65 Dudley Road , New Brunswick , New Jersey 08901-8520 , United States.
    Large yellow tea is a traditional beverage in China with a unique toasty flavor. A preliminary study using 3T3-L1 cells indicated that large yellow tea possessed more potent lipid-lowering efficacy than green, black, dark, and white teas. In the present study we further investigated its influence on metabolic syndrome in a high-fat diet (HFD) mouse model with an emphasis on dose response. Read More

    Cardiometabolic response of juvenile rainbow trout exposed to dietary selenomethionine.
    Aquat Toxicol 2018 May 8;198:175-189. Epub 2018 Mar 8.
    Department of Veterinary Biomedical Sciences, University of Saskatchewan, Saskatoon, Saskatchewan, S7N 5B4, Canada; Toxicology Centre, University of Saskatchewan, Saskatoon, Saskatchewan, S7N 5B3, Canada. Electronic address:
    Selenium (Se) is considered an essential trace element, involved in important physiological and metabolic functions for all vertebrate species. Fish require dietary concentrations of 0.1-0. Read More

    Resveratrol regulates hyperglycemia-induced modulations in experimental diabetic animal model.
    Biomed Pharmacother 2018 Mar 15;102:140-146. Epub 2018 Mar 15.
    Department of Pharmaceutical Chemistry, Government College University Faisalabad, Pakistan. Electronic address:
    Type 2 diabetes mellitus (T2DM) is a metabolic disorder that is associated with variable degrees of glucose intolerance, impaired insulin secretion, insulin resistance and increased hepatic glucose production. The aim of present study was to investigate the therapeutic potentials of resveratrol (RSV) alone and/or in combination with vitamin-E (Vit-E) against hyperglycemia-induced modulations using experimentally alloxan-induced diabetic animal model. Alloxan was used to induce diabetes mellitus in white albino rats and metformin (MF) was used as standard anti-diabetic drug to compare the therapeutic potentials of RSV (alone and/or with Vit-E) by estimating the effect of treatment on glycemia, insulin resistance, liver and kidney function biomarkers, anti-oxidant status, and serum levels of calcium and magnesium. Read More

    Deficiency of voltage-gated proton channel Hv1 attenuates streptozotocin-induced β-cell damage.
    Biochem Biophys Res Commun 2018 04 17;498(4):975-980. Epub 2018 Mar 17.
    Department of Biophysics, School of Physical Science, The Key Laboratory of Bioactive Materials, Ministry of Education, Nankai University, Tianjin 300071, PR China. Electronic address:
    Reactive oxygen species (ROS) impairs pancreatic β-cells and plays an important role in development of diabetes. Streptozotocin (STZ) can lead to β-cell dysfunction via inducing ROS production. The voltage-gated proton channel Hv1 contributes a majority of the charge compensation required for ROS production. Read More

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