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    β-Cell function in postmenopausal women with isolated postchallenge hyperglycemia.
    J Diabetes 2017 May 22. Epub 2017 May 22.
    Department of Medicine, National Yang-Ming University Hospital, Yi-Lan, Taiwan.
    Background: Isolated postchallenge hyperglycemia (IPH) is an early stage of type 2 diabetes mellitus (T2DM) with fasting glucose < 126 mg/dL and 2 h glucose ≥ 200 mg/dL. Observations of insulin secretion profile in subjects with IPH may provide insight to the pathogenesis of T2DM in older women.

    Methods: We recruited 555 naturally postmenopausal women without a history of T2DM for this study. Read More

    Diabetes and Cardiometabolic Risk Factors in Cambodia: Results from Two Screening Studies.
    J Diabetes 2017 May 22. Epub 2017 May 22.
    Cambodian Diabetes Association.
    Background: Despite growing attention to diabetes throughout Asia, data from Southeast Asia are limited. This article reports rates of diabetes, hypertension and obesity in Cambodia.

    Methods: Two studies were conducted across different regions of Cambodia: a 2012 screening study across urban, semi-urban and rural areas that used point of care capillary glucose for determination of diabetes (n = 13,997) and a 2005 epidemiological study with random selection from two main urban areas that used oral glucose tolerance tests for determination of diabetes (n = 1,863). Read More

    Type 2 diabetes and glucose intolerance in a population with intellectual disabilities: the STOP diabetes cross-sectional screening study.
    J Intellect Disabil Res 2017 May 21. Epub 2017 May 21.
    Diabetes Research Centre, University of Leicester, Leicester Diabetes Centre, Leicester General Hospital, Leicester, LE5 4PW, UK.
    Background: Adults with intellectual disabilities (ID) may be at increased risk of developing type 2 diabetes and cardiovascular disease, due to lifestyle factors, medications and other diagnosed conditions. Currently, there is lack of evidence on prevalence and prevention in this population. The aim of this study was to conduct a diabetes screening programme to determine prevalence of previously undiagnosed type 2 diabetes and impaired glucose regulation in people with ID. Read More

    Development and characterization of an experimental model of diet-induced metabolic syndrome in rabbit.
    PLoS One 2017 23;12(5):e0178315. Epub 2017 May 23.
    Department of Physiotherapy, Universitat de València, Valencia, Spain.
    Metabolic syndrome (MetS) has become one of the main concerns for public health because of its link to cardiovascular disease. Murine models have been used to study the effect of MetS on the cardiovascular system, but they have limitations for studying cardiac electrophysiology. In contrast, the rabbit cardiac electrophysiology is similar to human, but a detailed characterization of the different components of MetS in this animal is still needed. Read More

    Respiratory Effects and Systemic Stress Response Following Acute Acrolein Inhalation in Rats.
    Toxicol Sci 2017 May 24. Epub 2017 May 24.
    Environmental Public Health Division, NHEERL, US Environmental Protection Agency, Research Triangle Park, North Carolina.
    Previous studies have demonstrated that exposure to the pulmonary irritant ozone causes myriad systemic metabolic and pulmonary effects attributed to sympathetic and hypothalamus-pituitary-adrenal (HPA) axis activation, which are exacerbated in metabolically-impaired models. We examined respiratory and systemic effects following exposure to a sensory irritant acrolein to elucidate the systemic and pulmonary consequences in healthy and diabetic rat models. Male Wistar and Goto Kakizaki (GK) rats, a non-obese type II diabetic Wistar-derived model, were exposed by inhalation to 0, 2, or 4 ppm acrolein, 4h/day for 1 or 2 days. Read More

    Placental elasticity on patients with gestational diabetes: Single institution experience.
    J Chin Med Assoc 2017 May 20. Epub 2017 May 20.
    Baskent University, Obstetrics and Gynecology Department, Istanbul Education and Research Hospital, Turkey.
    Background: Gestational diabetes is defined as glucose intolerance which is first recognized in pregnancy. Oral glucose tolerance test (OGTT) is the cornerstone in diagnosing gestational diabetes. Placental elasticity evaluation is relatively new concept and is principally used for research purposes. Read More

    Hepatocyte-specific sirtuin 6 deletion predisposes to nonalcoholic steatohepatitis by up-regulation of Bach1, an Nrf2 repressor.
    FASEB J 2017 May 23. Epub 2017 May 23.
    Department of Biochemistry, Chonbuk National University Medical School, Jeonju, South Korea;
    Sirtuin (Sirt)6 has been implicated in negative regulation of inflammation and lipid metabolism, although its function in the progression from simple steatosis to nonalcoholic steatohepatitis (NASH) remains to be defined. To explore the role of hepatocyte Sirt6 in NASH development, we generated hepatocyte-specific Sirt6 knockout (KO) mice that were fed a high-fat and high-fructose (HFHF) diet for 16 wk. HFHF-fed KO mice had increased hepatic steatosis and inflammation and aggravated glucose intolerance and insulin resistance compared with wild-type mice. Read More

    Serum from pregnant women with gestational diabetes mellitus increases the expression of FABP4 mRNA in primary subcutaneous human pre-adipocytes.
    Obstet Gynecol Sci 2017 May 15;60(3):274-282. Epub 2017 May 15.
    Institute of Medical Science, Kangwon National University School of Medicine, Chuncheon, Korea.
    Objective: Gestational diabetes mellitus (GDM) is defined as glucose intolerance first detected during pregnancy. It can result in pregnancy complications such as birth injury, stillbirth. Fatty acid-binding protein 4 (FABP4), found in adipose tissue, is associated with insulin resistance, and type 2 diabetes. Read More

    Obesity-linked phosphorylation of SIRT1 by CK2 inhibits its nuclear localization and promotes fatty liver.
    Mol Cell Biol 2017 May 22. Epub 2017 May 22.
    Department of Molecular and Integrative Physiology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA
    Sirtuin1 (SIRT1) deacetylase delays and improves many obesity-related diseases, including non-alcoholic fatty liver disease (NAFLD) and diabetes, and has received great attention as a drug target. SIRT1 function is aberrantly low in obesity, so understanding the underlying mechanisms is important for drug development. Here, we show that obesity-linked phosphorylation of SIRT1 inhibits its function and promotes pathological symptoms of NAFLD. Read More

    Impact of Muscarinic M3 Receptor Antagonism on the Risk of Type 2 Diabetes in Antidepressant-Treated Patients: A Case-Controlled Study.
    CNS Drugs 2017 May 19. Epub 2017 May 19.
    Unit of PharmacoTherapy, -Epidemiology & -Economics, Groningen Research Institute of Pharmacy, University of Groningen, Antonius Deusinglaan 1, 9713 AV, Groningen, The Netherlands.
    Background: M3 muscarinic receptor antagonism has been associated with glucose intolerance and disturbance of insulin secretion.

    Objective: Our objective was to examine the risk of type 2 diabetes mellitus (T2DM) in patients using antidepressants with and without M3 muscarinic receptor antagonism (AD_antaM3 and AD_nonantaM3, respectively).

    Methods: We designed a case-control study using a pharmacy prescription database. Read More

    Old and Novel Functions of Caspase-2.
    Int Rev Cell Mol Biol 2017 27;332:155-212. Epub 2017 Jan 27.
    La Trobe Institute for Molecular Science, La Trobe University, Bundoora, VIC, Australia. Electronic address:
    Although caspase-2 is a highly conserved protease that has received a lot of research attention, consensus about its roles and the molecular mechanisms that underpin them has been elusive. Recent improvements to our understanding of the activities of caspase-2 have been facilitated by the development and refinement of techniques allowing identification of cellular processes instigated by this caspase. Following DNA damage, caspase-2 can be activated in a molecular complex called the "PIDDosome"; however, other stimuli provoke caspase-2-dependent activities that do not appear to involve this complex. Read More

    Prevalence and Predictors of Significant Fibrosis Among Subjects with Transient Elastography-Defined Nonalcoholic Fatty Liver Disease.
    Dig Dis Sci 2017 May 18. Epub 2017 May 18.
    Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea.
    Background/aims: Transient elastography (TE) can be used to assess the degree of liver fibrosis and steatosis. We investigated the prevalence and predictors of nonalcoholic fatty liver disease (NAFLD) with or without significant liver fibrosis in the general population.

    Methods: A total of 3033 subjects without alcoholic or chronic viral liver diseases who underwent a medical health check-up including TE were recruited from April 2013 to August 2014. Read More

    Is bisphenol A exposure associated with the development of glucose intolerance and increased insulin resistance in Thais?
    Nutr Health 2017 Jan 1:260106017708730. Epub 2017 Jan 1.
    1 Department of Medicine, Ramathibodi Hospital, Mahidol University, Thailand.
    Bisphenol A (BPA), the monomeric component of polycarbonate plastics, reportedly possesses endocrine-disrupting effects. Exposure to low levels of BPA during more vulnerable periods leads to abnormalities related to sexual development in experimental animals. Moreover, recently a few epidemiological studies in Caucasians have demonstrated the association of BPA exposure with type 2 diabetes. Read More

    Deleterious Metabolic Effects of High Fructose Intake: The Preventive Effect of Lactobacillus kefiri Administration.
    Nutrients 2017 May 17;9(5). Epub 2017 May 17.
    Neuroendocrinology Laboratory, Multidisciplinary Institute of Cellular Biology (IMBICE, CICPBA-CONICET-UNLP), 526 10 y 11, La Plata 1900, Argentina.
    Modern lifestyle and diets have been associated with metabolic disorders and an imbalance in the normal gut microbiota. Probiotics are widely known for their health beneficial properties targeting the gut microbial ecosystem. The aim of our study was to evaluate the preventive effect of Lactobacillus kefiri (L. Read More

    Fermented Moringa oleifera Decreases Hepatic Adiposity and Ameliorates Glucose Intolerance in High-Fat Diet-Induced Obese Mice.
    J Med Food 2017 May;20(5):439-447
    School of Life Science, Handong Global University , Pohang, Gyungbuk, Korea.
    Metabolic diseases, such as glucose intolerance and nonalcoholic fatty-liver disease (NAFLD), are primary risk factors for life-threatening conditions such as diabetes, heart attack, stroke, and hepatic cancer. Extracts from the tropical tree Moringa oleifera show antidiabetic, antioxidant, anti-inflammatory, and anticancer effects. Fermentation can further improve the safety and nutritional value of certain foods. Read More

    Antioxidant Status and Risk of Gestational Diabetes Mellitus: a Case-Control Study.
    Clin Nutr Res 2017 Apr 25;6(2):81-88. Epub 2017 Apr 25.
    Department of Clinical Nutrition, School of Nutrition and Food Sciences, Isfahan University of Medical Sciences, Isfahan 81746-73461, Iran.
    Gestational diabetes mellitus (GDM) is described as glucose intolerance diagnosed during pregnancy. Increased oxidative stress has implicated in diabetic problems. The aim of the current study was to compare antioxidant capacity and antioxidant nutrient intake between women with GDM (n = 40) and healthy pregnant women (n = 40). Read More

    Insulin sensitivity in relation to fat distribution and plasma adipocytokines among abusers of anabolic androgenic steroids.
    Clin Endocrinol (Oxf) 2017 May 13. Epub 2017 May 13.
    Center of Endocrinology and Metabolism, Department of Internal Medicine, Copenhagen University Hospitals, Herlev and Gentofte, Denmark.
    Objective: Abuse of anabolic androgenic steroids (AAS) is prevalent among young men, but information regarding effects on insulin sensitivity and fat distribution is limited. The objective was to investigate insulin sensitivity in relation to fat distribution and adipocytokines among current and former AAS abusers compared with controls.

    Design: Cross-sectional study among men involved in recreational strength training. Read More

    Maternal high-fat diet induces metabolic stress response disorders in offspring hypothalamus.
    J Mol Endocrinol 2017 May 12. Epub 2017 May 12.
    H Chen, School of Life Sciences, Faculty of Science, University of Technology, Sydney, Sydney, Australia.
    Maternal obesity has been shown to increase the risk of obesity and related disorders in the offspring, which has been partially attributed to changes of appetite regulators in the offspring hypothalamus. On the other hand, endoplasmic reticulum (ER) stress and autophagy have been implicated in hypothalamic neuropeptide dysregulation, thus may also play important roles in such transgenerational effect.  In this study, we show that offspring born to HFD-fed dams showed significantly increased body weight and glucose intolerance, adiposity and plasma triglyceride level at weaning. Read More

    Fructose increases corticosterone production in association with NADPH metabolism alterations in rat epididymal white adipose tissue.
    J Nutr Biochem 2017 Apr 6;46:109-116. Epub 2017 Apr 6.
    Universidad de Buenos Aires, Facultad de Farmacia y Bioquímica, Departamento de Farmacología, Cátedra de Farmacología, Buenos Aires, Argentina; CONICET-Universidad de Buenos Aires, Instituto de Investigaciones Cardiológicas (ININCA), Buenos Aires, Argentina. Electronic address:
    Metabolic syndrome is an array of closely metabolic disorders that includes glucose intolerance/insulin resistance, central obesity, dyslipidemia, and hypertension. Fructose, a highly lipogenic sugar, has profound metabolic effects in adipose tissue, and has been associated with the etiopathology of many components of the metabolic syndrome. In adipocytes, the enzyme 11 β-HSD1 amplifies local glucocorticoid production, being a key player in the pathogenesis of central obesity and metabolic syndrome. Read More

    Prevalence of Self-reported Allergic Diseases and IgE Levels: A 2010 KNHANES Analysis.
    Allergy Asthma Immunol Res 2017 Jul;9(4):329-339
    Division of Allergy and Chronic Respiratory Diseases, Center for Biomedical Sciences, Korea National Institute of Health, Korea Center for Diseases Control and Prevention, Osong, Korea.
    Purpose: The prevalence of allergic diseases is known to be associated with both demographic and environmental factors. Herein, we aimed to determine significant factors associated with the prevalence of allergic diseases and with total immunoglobulin E (tIgE) and specific immunoglobulin E (sIgE) levels in Korea.

    Methods: We analyzed unweighted data collected by the 2010 Korea National Health and Nutrition Examination Survey for 2,342 subjects who underwent serum tests for tIgE and sIgE to Dermatophagoides farinae, dog, and Blattella germanica, representing a sample of 16,003,645 citizens, by considering the sample weight and stratification. Read More

    Treating fructose-induced metabolic changes in mice with high-intensity interval training: insights in the liver, white adipose tissue and skeletal muscle.
    J Appl Physiol (1985) 2017 May 11:jap.00154.2017. Epub 2017 May 11.
    State University of Rio de Janeiro
    Fructose-rich caloric sweeteners induce adverse changes in the population metabolism. The study evaluated the effects of high-intensity interval training (HIIT) on a fructose feeding model, focusing on the liver, white adipose tissue (WAT), skeletal muscle, and their interplay. Male C57BL/6 mice were fed for 18 weeks one of the following diets: control (C; 5 % of total energy from fructose), or fructose (F; 55 % of total energy from fructose). Read More

    Incidence and Contributing Factors of Persistent Hyperglycemia at 6-12 Weeks Postpartum in Iranian Women with Gestational Diabetes: Results from LAGA Cohort Study.
    J Diabetes Res 2017 12;2017:9786436. Epub 2017 Apr 12.
    Department of Epidemiology and Biostatistics, Faculty of Health, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
    Background. A history of gestational diabetes is an important predictor of many metabolic disturbances later in life. Method. Read More

    Methylglyoxal-induced glycation changes adipose tissue vascular architecture, flow and expansion, leading to insulin resistance.
    Sci Rep 2017 May 10;7(1):1698. Epub 2017 May 10.
    Laboratory of Physiology, CNC.IBILI and Faculty of Medicine, University of Coimbra, Coimbra, Portugal.
    Microvascular dysfunction has been suggested to trigger adipose tissue dysfunction in obesity. This study investigates the hypothesis that glycation impairs microvascular architecture and expandability with an impact on insulin signalling. Animal models supplemented with methylglyoxal (MG), maintained with a high-fat diet (HFD) or both (HFDMG) were studied for periepididymal adipose (pEAT) tissue hypoxia and local and systemic insulin resistance. Read More

    Tyrosine kinase inhibitors of Ripk2 attenuate bacterial cell wall-mediated lipolysis, inflammation and dysglycemia.
    Sci Rep 2017 May 8;7(1):1578. Epub 2017 May 8.
    Department of Biochemistry and Biomedical Sciences and Department of Pediatrics, McMaster University, Hamilton, ON, L8N 3Z5, Canada.
    Inflammation underpins aspects of insulin resistance and dysglycemia. Microbiota-derived cell wall components such as muropeptides or endotoxin can trigger changes in host immunity and metabolism. Specific peptidoglycan motifs promote metabolic tissue inflammation, lipolysis and insulin resistance via Nucleotide-binding oligomerization domain-containing protein 1 (Nod1). Read More

    Increased birth weight is associated with altered gene expression in neonatal foreskin.
    J Dev Orig Health Dis 2017 May 9:1-9. Epub 2017 May 9.
    1Department of Pharmacology and Nutritional Sciences,University of Kentucky College of Medicine,Lexington,KY,USA.
    Elevated birth weight is linked to glucose intolerance and obesity health-related complications later in life. No studies have examined if infant birth weight is associated with gene expression markers of obesity and inflammation in a tissue that comes directly from the infant following birth. We evaluated the association between birth weight and gene expression on fetal programming of obesity. Read More

    Management of GH treatment in adult GH deficiency.
    Best Pract Res Clin Endocrinol Metab 2017 Feb 9;31(1):13-24. Epub 2017 Mar 9.
    Division of Endocrinology, Diabetes and Metabolism, Department of Medical Science, University of Turin, Turin, Italy.
    Growth hormone (GH) replacement therapy in adults with GH deficiency is still a challenge for the clinical endocrinologist and its implementation has still numerous difficulties and uncertainties. The decision to treat GH deficient adults requires a thoughtful and individualized evaluation of risks and benefits. Benefits have been found in body composition, bone health, cardiovascular risk factors, and quality of life. Read More

    Glucose Sensing by Skeletal Myocytes Couples Nutrient Signaling to Systemic Homeostasis.
    Mol Cell 2017 May;66(3):332-344.e4
    Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA; Department of Cell and Developmental Biology, University of Michigan Medical Center, Ann Arbor, MI 48109, USA. Electronic address:
    Skeletal muscle is a major site of postprandial glucose disposal. Inadequate insulin action in skeletal myocytes contributes to hyperglycemia in diabetes. Although glucose is known to stimulate insulin secretion by β cells, whether it directly engages nutrient signaling pathways in skeletal muscle to maintain systemic glucose homeostasis remains largely unexplored. Read More

    COX2 and NOS3 gene polymorphisms in women with gestational diabetes.
    J Gene Med 2017 May 5. Epub 2017 May 5.
    Department of Physiology, Pomeranian Medical University, Szczecin, Poland.
    Background: Gestational diabetes (GDM) is carbohydrate intolerance occurring in pregnancy. Low-grade inflammation plays an important role in the pathogenesis of this disorder. The aim of this study was to examine the association between COX2 (rs6681231) and NOS3 (rs1799983, rs2070744) gene polymorphisms and GDM. Read More

    Lifestyle interventions for the treatment of women with gestational diabetes.
    Cochrane Database Syst Rev 2017 May 4;5:CD011970. Epub 2017 May 4.
    Liggins Institute, The University of Auckland, Park Rd, Grafton, Auckland, New Zealand, 1142.
    Background: Gestational diabetes (GDM) is glucose intolerance, first recognised in pregnancy and usually resolving after birth. GDM is associated with both short- and long-term adverse effects for the mother and her infant. Lifestyle interventions are the primary therapeutic strategy for many women with GDM. Read More

    Lycopene Improves Insulin Sensitivity through Inhibition of STAT3/Srebp-1c-Mediated Lipid Accumulation and Inflammation in Mice fed a High-Fat Diet.
    Exp Clin Endocrinol Diabetes 2017 May 4. Epub 2017 May 4.
    Department of Endocrinology, Xi'an NO.1 Hospital, Xi'an, Shaanxi, China.
    In the past few years, metabolic disorders, such as type 2 diabetes and metabolic syndrome, has reached global prevalence. Lycopene is one of the major carotenoids in tomatoes, watermelons, red grapefruits, and guava. In the current study, using high fat diet (HFD)-fed mice, we investigated the effect of Lycopene on insulin resistance. Read More

    Development of a Novel Zebrafish Model for Type 2 Diabetes Mellitus.
    Sci Rep 2017 May 3;7(1):1461. Epub 2017 May 3.
    Graduate School of Regional Innovation Studies, Mie University, Tsu, Mie, Japan.
    Obesity is a major cause of type 2 diabetes mellitus (T2DM) in mammals. We have previously established a zebrafish model of diet-induced obesity (DIO zebrafish) by overfeeding Artemia. Here we created DIO zebrafish using a different method to induce T2DM. Read More

    Atherogenesis and metabolic dysregulation in LDL receptor-knockout rats.
    JCI Insight 2017 May 4;2(9). Epub 2017 May 4.
    Mechanisms of atherogenesis have been studied extensively in genetically engineered mice with disturbed cholesterol metabolism such as those lacking either the LDL receptor (Ldlr) or apolipoprotein E (apoe). Few other animal models of atherosclerosis are available. WT rabbits or rats, even on high-fat or high-cholesterol diets, develop sparse atherosclerotic lesions. Read More

    Tetrahydrobiopterin activates brown adipose tissue and regulates systemic energy metabolism.
    JCI Insight 2017 May 4;2(9). Epub 2017 May 4.
    Brown adipose tissue (BAT) is a central organ that acts to increase energy expenditure; its regulatory factors could be clinically useful in the treatment of obesity. Tetrahydrobiopterin (BH4) is an essential cofactor of tyrosine hydroxylase and nitric oxide synthase (NOS). Although BH4 regulates the known regulatory factors of BAT, such as noradrenaline (NA) and NO, participation of BH4 in BAT function remains unclear. Read More

    Genetic Disruption of Adenosine Kinase in Mouse Pancreatic β-Cells Protects Against High Fat Diet-Induced Glucose Intolerance.
    Diabetes 2017 May 3. Epub 2017 May 3.
    Department of Medicine and Division of Endocrinology, Stanford University, Stanford, CA, USA.
    Islet β-cells adapt to insulin resistance through increased insulin secretion and expansion. Type 2 diabetes (T2D) typically occurs when prolonged insulin resistance exceeds the adaptive capacity of β-cells. Our prior screening efforts led to the discovery that Adenosine kinase (ADK) inhibitors stimulate β-cell replication. Read More

    Astrocytic Process Plasticity and IKKβ/NF-κB in Central Control of Blood Glucose, Blood Pressure, and Body Weight.
    Cell Metab 2017 May;25(5):1091-1102.e4
    Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY 10461, USA; Diabetes Research Center, Albert Einstein College of Medicine, Bronx, NY 10461, USA; Institute of Aging, Albert Einstein College of Medicine, Bronx, NY 10461, USA. Electronic address:
    Central regulation of metabolic physiology is mediated critically through neuronal functions; however, whether astrocytes are also essential remains unclear. Here we show that the high-order processes of astrocytes in the mediobasal hypothalamus displayed shortening in fasting and elongation in fed status. Chronic overnutrition and astrocytic IKKβ/NF-κB upregulation similarly impaired astrocytic plasticity, leading to sustained shortening of high-order processes. Read More

    Observation of Parkin-Mediated Mitophagy in Pancreatic β-Cells.
    Methods Mol Biol 2017 May 3. Epub 2017 May 3.
    Department of Cardiovascular Medicine, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajii-cho Kamigyo-ku, Kyoto, Japan.
    Mitophagy is a cellular process of autophagy-based mitochondrial degradation that eliminates dysfunctional mitochondria and ensures cellular homeostasis. In pancreatic islet β-cells, mitochondria play a pivotal role in glucose-stimulated insulin secretion through ATP production from glucose oxidation. Recent studies have shown that impaired mitophagy and the subsequent mitochondrial compromise contribute to β-cell dysfunction and glucose intolerance. Read More

    The Association of Left Ventricular Mass Index with Metabolic Syndrome in Comparison to Hypertensive Patients.
    J Cardiovasc Echogr 2016 Apr-Jun;26(2):42-47
    Department of Medicine, Mahatma Gandhi Hospital, Jaipur, Rajasthan, India.
    Background And Objectives: The metabolic syndrome (MS) is a condition associated with the clustering of risk factors including high blood pressure (BP), abdominal obesity, glucose intolerance, and dyslipidemia; which increases cardiovascular morbidity and mortality. High burden of subclinical disease component of MS contributes to the increased risk by causing left ventricular (LV) hypertrophy, thereby affecting long-term prognosis. This cross-sectional study uncovers the role of LV hypertrophy (LVH) and LV mass index (LVMI) in patients with MS in comparison to hypertensive patients. Read More

    Impact of obesity with impaired glucose tolerance on retinal degeneration in a rat model of metabolic syndrome.
    Mol Vis 2017 14;23:263-274. Epub 2017 Apr 14.
    National Institute of Nutrition, Hyderabad, India.
    Purpose: Metabolic syndrome (MetS) is associated with several degenerative diseases, including retinal degeneration. Previously, we reported on progressive retinal degeneration in a spontaneous obese rat (WNIN/Ob) model. In this study, we investigated the additional effect of impaired glucose tolerance (IGT), an essential component of MetS, on retinal degeneration using the WNIN/GR-Ob rat model. Read More

    Renal resistive index reflects Fontan pathophysiology and predicts mortality.
    Heart 2017 May 2. Epub 2017 May 2.
    Department of Pediatric Thoracic Surgery, National Cerebral and Cardiovascular Center, Suita, Osaka, Japan.
    Objectives: The renal resistive index (RRI) reflects non-renal pathophysiology, such as great artery stiffness, haemodynamics and even end-organ damage in patients with hypertension. This study was conducted to clarify the clinical significance of the RRI in Fontan pathophysiology.

    Methods: We measured the RRI in 280 consecutive Fontan patients and 36 healthy controls. Read More

    Anti-islet cell antibodies in a sample of Egyptian females with gestational diabetes and its relation to development of type 1 diabetes mellitus.
    Curr Diabetes Rev 2017 May 1. Epub 2017 May 1.
    Department of Obstetrics and Gynecology, Ain Shams University Hospital, Cairo. Egypt.
    Background: Gestational diabetes mellitus is any degree of glucose intolerance with first diagnosis during pregnancy; it affects 3-10% of pregnancies. The presence of diabetes-related autoantibodies has shown to be able to predict the development of type 1 diabetes before hyperglycemia arises.

    Objective: To recognize the prevalence of islet cell antibodies among a sample of Egyptian females with gestational diabetes and its possible relation to development of Type 1 diabetes within one year postpartum. Read More

    Using kisspeptin to assess GnRH function in an unusual case of primary amenorrhoea.
    Endocrinol Diabetes Metab Case Rep 2017 27;2017. Epub 2017 Mar 27.
    Department of Endocrinology & Metabolism, Imperial College LondonUK.
    Summary: Primary amenorrhoea is defined as the failure to commence menstruation by the age of 15 years, in the presence of normal secondary sexual development. The potential causes of primary amenorrhoea extend from structural to chromosomal abnormalities. Polycystic ovarian syndrome (PCOS) is a common cause of secondary amenorrhoea but an uncommon cause of primary amenorrhoea. Read More

    Lipoprotein lipase in hypothalamus is a key regulator of body weight gain and glucose homeostasis in mice.
    Diabetologia 2017 Apr 29. Epub 2017 Apr 29.
    Unité de Biologie Fonctionnelle et Adaptative, Sorbonne Paris Cité, CNRS UMR 8251, Université Paris Diderot, Bâtiment Buffon, P. O. box 7126, 4, rue Marie-Andrée Lagroua Weill-Halle, 75205, Paris Cedex 13, France.
    Aims/hypothesis: Regulation of energy balance involves the participation of many factors, including nutrients, among which are circulating lipids, acting as peripheral signals informing the central nervous system of the energy status of the organism. It has been shown that neuronal lipoprotein lipase (LPL) participates in the control of energy balance by hydrolysing lipid particles enriched in triacylglycerols. Here, we tested the hypothesis that LPL in the mediobasal hypothalamus (MBH), a well-known nucleus implicated in the regulation of metabolic homeostasis, could also contribute to the regulation of body weight and glucose homeostasis. Read More

    Population-Level Outcomes with a 2-Step Approach for Gestational Diabetes Screening and Diagnosis.
    Can J Diabetes 2017 Apr 25. Epub 2017 Apr 25.
    University of Alberta, Canadian Vigour Centre, Edmonton, Alberta, Canada; University of Alberta, School of Public Health, Edmonton, Alberta, Canada.
    Objectives: To examine outcomes associated with alternative glucose thresholds in a 2-step approach for screening and diagnosing gestational diabetes mellitus (GDM).

    Methods: We studied 178,527 pregnancies between 2008 and 2012 in Alberta, Canada. They were categorized retrospectively as normal 50 g screen (n=144,191); normal 75 g oral glucose tolerance test (OGTT) (n=21,248); abnormal at glucose thresholds suggested by the International Association of Diabetes and Pregnancy Group (IADPSG) (HAPO 1. Read More

    Implication of a novel Gla-containing protein, Gas6 in the pathogenesis of insulin resistance, impaired glucose homeostasis, and inflammation: A review.
    Diabetes Res Clin Pract 2017 Apr 13;128:74-82. Epub 2017 Apr 13.
    Academy of Scientific and Innovative Research, Chennai 600113, India; Biological Science and Technology Division, CSIR-North East Institute of Science and Technology, Jorhat, Assam 785006, India. Electronic address:
    Growth arrest specific 6 (Gas6), a vitamin K-dependent protein plays a significant role in the regulation of cellular homeostasis via binding with TAM-receptor tyrosine kinases. Several studies reported the role of Gas6 in cancer, glomerular injury, obesity, and inflammation, however, very little is known about its role in insulin resistance (IR) and impaired glucose metabolism. Majority of the studies reported an inverse correlation of Gas6 protein levels or gene polymorphism with plasma glucose, HbA1c, IR, and inflammatory cytokines among type 2 diabetes (T2D) and obese subjects. Read More

    Pectic Bee Pollen Polysaccharide from Rosa rugosa Alleviates Diet-Induced Hepatic Steatosis and Insulin Resistance via Induction of AMPK/mTOR-Mediated Autophagy.
    Molecules 2017 Apr 28;22(5). Epub 2017 Apr 28.
    School of Life Sciences, Northeast Normal University, Changchun 130024, China.
    Despite it is used as a nutraceutical against diabetes and obesity, the mechanism of action of bee pollen is still unclear. Pectic bee pollen polysaccharide (RBPP-P) was isolated from Rosa rugosa, and its structure was characterized by (13)C-NMR and Fourier transform-infrared spectroscopy (FT-IR). Using high glucose and fatty acids-treated HepG2 cells and high fat diet (HFD)-induced obesity mice, we detected its effect on insulin function and lipid metabolism based on autophagy. Read More

    GLP-1 and GIP Levels in Patients With Hyperthyroidism: The Effect of Antithyroid Treatment.
    Ann Pharmacother 2017 Apr 1:1060028017707221. Epub 2017 Apr 1.
    1 Akdeniz University, School of Medicine, Antalya, Turkey.
    Background: Incretin hormones (glucagon-like peptide-1 [GLP-1] and gastric inhibitory polypeptide [GIP]) may play a role in the development of glucose intolerance and hyperglycemia in patients with hyperthyroidism.

    Objective: We aimed to assess both incretin levels and treatment-induced changes in incretin levels in those with hyperthyroidism.

    Methods: A total of 24 subjects (12 with hyperthyroidism and 12 healthy) were enrolled in the study. Read More

    Plasma Glycated CD59, a Novel Biomarker for Detection of Pregnancy-Induced Glucose Intolerance.
    Diabetes Care 2017 Apr 27. Epub 2017 Apr 27.
    Division of Hematology, Brigham and Women's Hospital, Boston, MA
    Objective: Plasma glycated CD59 (pGCD59) is an emerging biomarker in diabetes. We assessed whether pGCD59 could predict the following: the results of the glucose challenge test (GCT) for screening of gestational diabetes mellitus (GDM) (primary analysis); and the diagnosis of GDM and prevalence of large for gestational age (LGA) newborns (secondary analyses).

    Research Design And Methods: Case-control study of 1,000 plasma samples from women receiving standard prenatal care, 500 women having a normal GCT (control subjects) and 500 women with a failed GCT and a subsequent oral glucose tolerance test (case patients). Read More

    Bariatric surgery in individuals with severe cognitive impairment: report of two cases.
    Sao Paulo Med J 2017 Apr 20. Epub 2017 Apr 20.
    MD, MSc, PhD. Full Professor, Department of Surgery, Faculdade de Ciências Médicas da Universidade Estadual de Campinas (FCM-UNICAMP), Campinas (SP), Brazil.
    Context:: Bariatric surgery has become the gold-standard treatment for refractory morbid obesity. Obesity is frequently associated with certain syndromes that include coexisting cognitive deficits. However, the outcomes from bariatric surgery in this group of individuals remain incompletely determined. Read More

    Serotonin transporter deficiency drives estrogen-dependent obesity and glucose intolerance.
    Sci Rep 2017 Apr 25;7(1):1137. Epub 2017 Apr 25.
    Department of Pharmaceutics, University of Washington, Seattle, Washington, USA.
    Depression and use of antidepressant medications are both associated with increased risk of obesity, potentially attributed to a reduced serotonin transporter (SERT) function. However, how SERT deficiency promotes obesity is unknown. Here, we demonstrated that SERT (-/-) mice display abnormal fat accumulation in both white and brown adipose tissues, glucose intolerance and insulin resistance while exhibiting suppressed aromatase (Cyp19a1) expression and reduced circulating 17β-estradiol levels. Read More

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