Testosterone is protective against impaired glucose metabolism in male intrauterine growth-restricted offspring.
- Suttira Intapad,
- John Henry Dasinger,
- Joel M Fahling,
- Miles A Backstrom,
- Barbara T Alexander
PLoS One 2017 16;12(11):e0187843. Epub 2017 Nov 16.
Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS, United States of America.
Placental insufficiency alters the intrauterine environment leading to increased risk for chronic disease including impaired glucose metabolism in low birth weight infants. Using a rat model of low birth weight, we previously reported that placental insufficiency induces a significant increase in circulating testosterone in male intrauterine growth-restricted offspring (mIUGR) in early adulthood that is lost by 12 months of age. Numerous studies indicate testosterone has a positive effect on glucose metabolism in men. Read More