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    Effect and Mechanisms of Diabetes Resolution According to the Range of Gastric Resection and the Length of Anastomosis in Animal Models: Implication for Gastric Cancer Surgery in Patients with Diabetes Mellitus.
    World J Surg 2017 Sep 19. Epub 2017 Sep 19.
    Department of Surgery, Seoul National University College of Medicine, Seoul National University Hospital, 101 Daehang-ro, Jongno-gu, Seoul, 110-744, Korea.
    Background: To examine the effect and mechanism of Roux-en-Y gastric bypass (RYGB) on the improvement of diabetes according to the length of anastomosis and the gastric pouch volume in an animal model.

    Methods: Glucose intolerance was induced with a high-fat diet for 3 months in Sprague-Dawley rats. The animals were subjected to conventional RYGB (cRYGB; 5% gastric pouch with 15-cm Roux limb, 40-cm biliopancreatic limb; n = 9), short-limb RYGB (sRYGB; 5%, 8, 4 cm; n = 9), fundus-sparing RYGB (fRYGB; 30%, 8, 4 cm; n = 9), or sham operation (n = 9). Read More

    Histone Deacetylase Inhibition Ameliorates Hypertension and Hyperglycemia in a model of Cushing's Syndrome.
    Am J Physiol Endocrinol Metab 2017 Sep 19:ajpendo.00267.2017. Epub 2017 Sep 19.
    Kyungpook National University
    Cushing's syndrome (CS) caused by hypercortisolism is occasionally accompanied by metabolic disorders such as hypertension, diabetes mellitus (DM), dyslipidemia and central obesity. Thus, morbidity and mortality, observed in cardiovascular disease, are elevated in patients with CS. We hypothesized that HDAC inhibition (HDACi) decreased transcriptional activity of glucocorticoid receptor (GR), which ameliorates hypertension and hyperglycemia in patients with CS. Read More

    Female ClockΔ19/Δ19 Mice are Protected from the Development of Age-Dependent Cardiomyopathy.
    Cardiovasc Res 2017 Sep 12. Epub 2017 Sep 12.
    Centre for Cardiovascular Investigations, Department of Biomedical Sciences, University of Guelph, Canada.
    Aims: Circadian rhythms are important for healthy cardiovascular physiology and they are regulated by the molecular circadian mechanism. Previously, we showed that disruption of the circadian mechanism factor CLOCK in male Clock Δ19/Δ19 mice led to development of age-dependent cardiomyopathy. Here, we investigate the role of biological sex in protecting against heart disease in aging female Clock Δ19/Δ19 mice. Read More

    Risk of glucose intolerance and gestational diabetes mellitus in relation to maternal habitual snoring during early pregnancy.
    PLoS One 2017 19;12(9):e0184966. Epub 2017 Sep 19.
    Department of Epidemiology, Harvard T. Chan School of Public Health, Boston, Massachusetts, United States of America.
    Background: Obstructive sleep apnea (OSA) or habitual snoring is known to be associated with impaired glucose tolerance and type 2 diabetes among both men and non-pregnant women. We examined the association of habitual snoring during early pregnancy with risk of impaired glucose tolerance (IGT) and gestational diabetes mellitus (GDM).

    Methods: A cohort of 1,579 women was interviewed during early pregnancy. Read More

    Fructooligosaccharide (FOS) and Galactooligosaccharide (GOS) Increase Bifidobacterium but Reduce Butyrate Producing Bacteria with Adverse Glycemic Metabolism in healthy young population.
    Sci Rep 2017 Sep 18;7(1):11789. Epub 2017 Sep 18.
    State Key Laboratory of Organ Failure Research, Division of Laboratory Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou, 510282, China.
    The gut microbiota has been implicated in glucose intolerance and its progression towards type-2 diabetes mellitus (T2DM). Relevant randomized clinical trial with prebiotic intervention was inadequate. We sought to evaluate the impact of fructooligosaccharides (FOS) and galactooligosaccharides (GOS) on glycemia during oral glucose tolerance test (OGTT) and intestinal microbiota. Read More

    Sulforaphane improves disrupted ER-mitochondria interactions and suppresses exaggerated hepatic glucose production.
    Mol Cell Endocrinol 2017 Sep 16. Epub 2017 Sep 16.
    Lund University Diabetes Centre, Jan Waldenströms gata 35, SE, 20502 Malmö, Sweden; Department of Neuroscience and Physiology, University of Gothenburg, Medicinaregatan 11, SE, 41390 Göteborg, Sweden. Electronic address:
    Aims: Exaggerated hepatic glucose production is one of the hallmarks of type 2 diabetes. Sulforaphane (SFN) has been suggested as a new potential anti-diabetic compound. However, the effects of SFN in hepatocytes are yet unclear. Read More

    Scopoletin Supplementation Ameliorates Steatosis and Inflammation in Diabetic Mice.
    Phytother Res 2017 Sep 18. Epub 2017 Sep 18.
    Department of Food and Nutrition, Sunchon National University, Suncheon, 57922, Korea.
    Scopoletin is a bioactive component in many edible plants and fruits. This study investigated the effects of scopoletin on hepatic steatosis and inflammation in a high-fat diet fed type 1 diabetic mice by comparison with metformin. Scopoletin (0. Read More

    White matter microstructure and cognitive decline in metabolic syndrome: A review of diffusion tensor imaging.
    Metabolism 2017 Sep 8. Epub 2017 Sep 8.
    Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, 185 Pilgrim Road, Palmer 127, Boston, MA 02215, USA. Electronic address:
    Metabolic syndrome is a cluster of cardiovascular risk factors defined by the presence of abdominal obesity, glucose intolerance, hypertension and/or dyslipidemia. It is a major public health epidemic worldwide, and a known risk factor for the development of cognitive dysfunction and dementia. Several studies have demonstrated a positive association between the presence of metabolic syndrome and worse cognitive outcomes, however, evidence of brain structure pathology is limited. Read More

    Inactivation of TNF/LT locus alters mouse metabolic response to concentrated ambient PM2.5.
    Toxicology 2017 Sep 14;390:100-108. Epub 2017 Sep 14.
    Department of Medicine Cardiology Division, University of Maryland School of Medicine, Baltimore, MD 21201, USA; Department of Environmental Health, School of Public Health, Fudan University, Shanghai 200032, China. Electronic address:
    Background: Exposure to ambient fine particulate matter (PM2.5) is associated with increased cardiometabolic morbidity and mortality. This is widely believed to be attributable to PM2. Read More

    Reconfirmation of improved tolerance to a new amino acid-based formula by infants with cow's milk protein allergy.
    Asia Pac J Clin Nutr 2017 ;26(6):1088-1091
    Center for Management of Infants with Cow's Milk Protein Allergy, Faculty of Medicine Siriraj Hospital, Mahidol University, Thailand.
    Background And Objectives: Reasons for intolerance to commercial amino acid-based formulas (cAAF) in infants diagnosed with cow's milk protein allergy (CMA) remain unknown. We assume that minute amounts of proteins, presenting in the glucose polymers derived from corn starch (cGPs), can elicit the intolerance to the cAAFs observed in some infants with CMA. By replacing cGPs with glucose polymers derived from rice starch (rGPs), a new amino acid-based (nAAF) formula has been shown to be better tolerated than an existing cAAF. Read More

    3-(2-amino-ethyl)-5-[3-(4-butoxyl-phenyl)-propylidene]-thiazolidine-2,4-dione (K145) ameliorated dexamethasone induced hepatic gluconeogenesis through activation of Akt/FoxO1 pathway.
    Biochem Biophys Res Commun 2017 Sep 11. Epub 2017 Sep 11.
    Key Laboratory of Hormones and Development (Ministry of Health), Tianjin Key Laboratory of Metabolic Diseases, Tianjin Metabolic Diseases Hospital & Tianjin Institute of Endocrinology, Tianjin Medical University, No.22 Qixiangtai Road, Heping District, 300070 Tianjin, China. Electronic address:
    3-(2-amino-ethyl)-5-[3-(4-butoxyl-phenyl)-propylidene]-thiazolidine-2,4-dione (K145) is identified as a selective SphK2 inhibitor. It was previously reported as an anti-tumor agent, in this study we demonstrated that K145 was able to regulate hepatic gluconeogenesis and improve glucose intolerance in mice. C57BL/6 mice treated with dexamethasone injection were used as experimental animals, which exhibited impaired glucose tolerance and increased gluconeogenetic enzymes. Read More

    Long-term feeding of red algae (Gelidium amansii) ameliorates glucose and lipid metabolism in a high fructose diet-impaired glucose tolerance rat model.
    J Food Drug Anal 2017 Jul 12;25(3):543-549. Epub 2016 Aug 12.
    Department of Food Science, National Taiwan Ocean University, Keelung, Taiwan, ROC. Electronic address:
    This study was designed to investigate the effect of Gelidium amansii (GA) on carbohydrate and lipid metabolism in rats with high fructose (HF) diet (57.1% w/w). Five-week-old male Sprague-Dawley rats were fed a HF diet to induce glucose intolerance and hyperlipidemia. Read More

    Hyperandrogenemia Induced by Letrozole Treatment of Pubertal Female Mice Results in Hyperinsulinemia Prior to Weight Gain and Insulin Resistance.
    Endocrinology 2017 Sep;158(9):2988-3003
    Department of Reproductive Medicine, University of California, San Diego, La Jolla, California 92093.
    Women with polycystic ovary syndrome (PCOS) diagnosed with hyperandrogenism and ovulatory dysfunction have an increased risk of developing metabolic disorders, including type 2 diabetes and cardiovascular disease. We previously developed a model that uses letrozole to elevate endogenous testosterone levels in female mice. This model has hallmarks of PCOS, including hyperandrogenism, anovulation, and polycystic ovaries, as well as increased abdominal adiposity and glucose intolerance. Read More

    Calculation of Glucose Dose for Intraperitoneal Glucose Tolerance Tests in Lean and Obese Mice.
    J Am Assoc Lab Anim Sci 2017 Jan;56(1):95-97
    Insulin Pharmacology, Novo Nordisk A/S, Maaloev, Denmark.
    Glucose tolerance tests are used frequently in nonclinical research with laboratory animals, for example during characterization of obese phenotypes. Despite published standard operating procedures for glucose tolerance tests in rodents, how glucose doses should be calculated when obese and lean animals are compared is not well documented. Typically the glucose dose is calculated as 2 g/kg body weight, regardless of body composition. Read More

    PI3Kγ ablation does not promote diabetes in db/db mice, but improves insulin sensitivity and reduces pancreatic β-cell apoptosis.
    FASEB J 2017 Sep 13. Epub 2017 Sep 13.
    Department of Molecular and Clinical Medicine, The Wallenberg Laboratory, University of Gothenburg, Gothenburg, Sweden;
    PI3Kγ has emerged as a promising target for the treatment of obesity and insulin resistance; however, previous studies have indicated that PI3Kγ activity in pancreatic β-cells is required for normal insulin secretion in response to glucose. Hence, a possible deterioration of insulin secretion capacity in patients who are predisposed to the failure of pancreatic β-cell function is a major concern for the pharmacologic inhibition of PI3Kγ. To address this issue, we investigated the effects of PI3Kγ ablation in db/db diabetic mice, a genetic model of obesity-driven β-cell failure and diabetes. Read More

    A history of obesity leaves an inflammatory fingerprint in liver and adipose tissue.
    Int J Obes (Lond) 2017 Sep 13. Epub 2017 Sep 13.
    JRG Adipocytes and Metabolism, Institute for Diabetes and Obesity, Helmholtz Diabetes Center at Helmholtz Center Munich, Garching, Germany.
    Background/objective: Dieting is a popular yet often ineffective way to lower body weight, as the majority of people regain most of their pre-dieting weights in a relatively short time. The underlying molecular mechanisms driving weight regain and the increased risk for metabolic disease are still incompletely understood. Here we investigate the molecular alterations inherited from a history of obesity. Read More

    Development of metabolic syndrome in high-sucrose diet fed rats is not associated with decrease in adiponectin levels.
    Endocrine 2017 Sep 6. Epub 2017 Sep 6.
    Department of Endocrinology, Centre for Diabetes Endocrinology & Metabolism, University College of Medical Sciences (University of Delhi) & GTB Hospital, Delhi, India.
    Purpose: Association of circulating adiponectin levels with metabolic syndrome has been controversial, with studies reporting low as well as high circulating adiponectin levels in metabolic syndrome. Present study aims to examine prospectively the course of circulating adiponectin levels during development of metabolic syndrome in a diet-induced rat model of metabolic syndrome.

    Methods: In a prospective study, eight-week-old male wistar rats were randomized into two groups (n = 24 each). Read More

    Analysis of factors influencing glucose tolerance in Japanese patients with non-alcoholic fatty liver disease.
    Diabetol Metab Syndr 2017 5;9:65. Epub 2017 Sep 5.
    Department of Endocrinology, Metabolism, and Nephrology, Kochi Medical School, Kochi University, Kohasu, Oko-cho, Nankoku, Kochi 783-8505 Japan.
    Background: While the association of the prevalence of non-alcoholic fatty liver disease (NAFLD) with impaired glucose metabolism has been reported, the factors influencing glucose tolerance in NAFLD remain to be clarified.

    Methods: Glucose tolerance of 131 Japanese patients diagnosed as NAFLD by histological findings of liver biopsy specimen was examined using 75 g-OGTT. According to Matteoni's classification, patients were divided to 4 groups [M1 ~ 4, M1, 2: non-alcoholic fatty liver (NAFL); and M3, 4: non-alcoholic steatohepatitis (NASH)]. Read More

    Association between Diastolic Dysfunction with Inflammation and Oxidative Stress in Females ob/ob Mice.
    Front Physiol 2017 23;8:572. Epub 2017 Aug 23.
    Hypertension Unit, Heart Institute (InCor), Faculdade de Medicina da Universidade de São PauloSão Paulo, Brazil.
    Objective: To evaluate autonomic and cardiovascular function, as well as inflammatory and oxidative stress markers in ob/ob female mice. Methods: Metabolic parameters, cardiac function, arterial pressure (AP), autonomic, hormonal, inflammatory, and oxidative stress markers were evaluated in 12-weeks female wild-type (WT group) and ob/ob mice (OB group). Results: OB animals showed increased body weight, blood glucose, and triglyceride levels, along with glucose intolerance, when compared to WT animals. Read More

    Sasa veitchii extract reduces obesity-induced insulin resistance and hepatic steatosis in obese mice fed a high-fat diet.
    Nagoya J Med Sci 2017 Aug;79(3):279-290
    College of Pharmacy, Kinjo Gakuin University, Nagoya, Japan.
    The aim of this study was to investigate the therapeutic effect of Sasa veitchii leaf extract (SE) on features of obesity induced by a high-fat diet (HFD), such as hyperglycemia, insulin resistance, and inflammatory response. Four-week-old male ddY mice were freely fed HFD or control normal diet for 12 weeks; half was given SE in addition twice per day in weeks 8-12. Glucose and insulin intolerance were estimated, and body weight measured, weekly throughout the study. Read More

    Carbonyl reductase 1 catalyzes 20β-reduction of glucocorticoids, modulating receptor activation and metabolic complications of obesity.
    Sci Rep 2017 Sep 6;7(1):10633. Epub 2017 Sep 6.
    University/BHF Centre for Cardiovascular Science, The Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK.
    Carbonyl Reductase 1 (CBR1) is a ubiquitously expressed cytosolic enzyme important in exogenous drug metabolism but the physiological function of which is unknown. Here, we describe a role for CBR1 in metabolism of glucocorticoids. CBR1 catalyzes the NADPH- dependent production of 20β-dihydrocortisol (20β-DHF) from cortisol. Read More

    Hepatic GALE Regulates Whole Body Glucose Homeostasis by Modulating Tff3 Expression.
    Diabetes 2017 Sep 6. Epub 2017 Sep 6.
    Touchstone Diabetes Center, UT Southwestern Medical Center, Dallas, Texas, 75390, USA
    Transcripts of key enzymes in the Leloir pathway of galactose metabolism in mouse livers are significantly increased after chronic high-fat high-sucrose feeding. UDP-galactose-4-epimerase (GALE) is the last enzyme in this pathway that converts UDP-galactose to UDP-glucose and was previously identified as a downstream target of the endoplasmic reticulum (ER) stress effector spliced X-box binding protein 1, suggesting an interesting crosstalk between galactose and glucose metabolism in the context of hepatic ER stress and whole body metabolic fitness. But its specific role in glucose metabolism is not established. Read More

    Growth Differentiation Factor 15 Mediates Systemic Glucose Regulatory Action of T Helper Type 2 Cytokines.
    Diabetes 2017 Sep 5. Epub 2017 Sep 5.
    Research Center for Endocrine and Metabolic Diseases, Chungnam National University School of Medicine, 282 Munhwaro, Daejeon 35015, Korea
    Th2 cytokines, including IL-13 and IL-4, produced in adipose tissue are critical regulators of intra-adipose and systemic lipid and glucose metabolism. Furthermore, IL-13 is a potential therapy for insulin resistance in obese mouse models. Here, we examined mediators produced by adipocytes that are responsible for regulating systemic glucose homeostasis in response to Th2 cytokines. Read More

    Dual specificity phosphatase 6 deficiency is associated with impaired systemic glucose tolerance and reversible weight retardation in mice.
    PLoS One 2017 5;12(9):e0183488. Epub 2017 Sep 5.
    Institute for Diabetes and Obesity, Helmholtz Diabetes Center, Helmholtz Zentrum München, Neuherberg, Germany.
    Here, we aimed to investigate the potential role of DUSP6, a dual specificity phosphatase, that specifically inactivates extracellular signal-regulated kinase (ERK), for the regulation of body weight and glucose homeostasis. We further assessed whether metabolic challenges affect Dusp6 expression in selected brain areas or white adipose tissue. Hypothalamic Dusp6 mRNA levels remained unchanged in chow-fed lean vs. Read More

    Prolonged fasting elicits increased hepatic triglyceride accumulation in rats born to dexamethasone-treated mothers.
    Sci Rep 2017 Sep 4;7(1):10367. Epub 2017 Sep 4.
    Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, Brazil.
    We investigated the effect of dexamethasone during the last week of pregnancy on glucose and lipid metabolism in male offspring. Twelve-week old offspring were evaluated after fasting for 12-hours (physiological) and 60-hours (prolonged). Physiological fasting resulted in glucose intolerance, decreased glucose clearance after pyruvate load and increased PEPCK expression in rats born to dexamethasone-treated mothers (DEX). Read More

    Agrimonia pilosa Ledeb. aqueous extract improves impaired glucose tolerance in high-fat diet-fed rats by decreasing the inflammatory response.
    BMC Complement Altern Med 2017 Sep 5;17(1):442. Epub 2017 Sep 5.
    Division of Applied Food System, Major of Food and Nutrition, Seoul Women's University, Seoul, 01797, South Korea.
    Background: Agrimonia pilosa Ledeb. is a medicinal plant with physiological activities such as anti-cancer, antioxidant, anti-inflammatory activities and in vitro anti-diabetic activity. However, the effects of aqueous extracts from A. Read More

    Should Subclinical Hypothyroidism Be an Exclusion Criterion for the Diagnosis of Polycystic Ovary Syndrome?
    J Reprod Infertil 2017 Apr-Jun;18(2):242-250
    University of Adelaide, Robinson Research Institute and Fertility SA, Adelaide, Australia.
    Background: The purpose of the study was to examine whether patients with subclinical hypothyroidism (SCH) should be excluded before making a diagnosis of polycystic ovary syndrome (PCOS).

    Methods: Seven hundred sixteen patients, 462 with true PCOS, 31 with PCOS-SCH, and 223 normal cycling women were enrolled. Clinical, metabolic, and hormonal parameters among the groups were investigated. Read More

    Inhibition of hypothalamic leukemia inhibitory factor exacerbates diet-induced obesity phenotype.
    J Neuroinflammation 2017 Sep 2;14(1):178. Epub 2017 Sep 2.
    Laboratory of Cell Signaling, University of Campinas, Campinas, São Paulo, 13084-970, Brazil.
    Background: The consumption of large amounts of dietary fats can trigger an inflammatory response in the hypothalamus and contribute to the dysfunctional control of caloric intake and energy expenditure commonly present in obesity. The objective of this study was to identify chemokine-related transcripts that could be involved in the early stages of diet-induced hypothalamic inflammation.

    Methods: We used immunoblot, PCR array, real-time PCR, immunofluorescence staining, glucose and insulin tolerance tests, and determination of general metabolic parameters to evaluate markers of inflammation, body mass variation, and glucose tolerance in mice fed a high-fat diet. Read More

    The grading effect of abnormal glucose status on arterial stiffness and a new threshold of 2-hour post-load glucose based on a Chinese community study.
    J Diabetes Investig 2017 Sep 1. Epub 2017 Sep 1.
    Department of Epidemiology and Biostatistics, School of Public Health Peking University Health Science Center, Beijing, 100191, China.
    Aims/introduction: To investigate the relation between various glucose metabolic status and arterial stiffness, and further explore the threshold of blood glucose indices for the risk of arterial stiffness.

    Materials And Methods: The cross-sectional study included 4851 individuals from a Chinese community. Overnight fasting blood glucose and 2-hour post-load glucose sampled. Read More

    Wfs1- deficient rats develop primary symptoms of Wolfram syndrome: insulin-dependent diabetes, optic nerve atrophy and medullary degeneration.
    Sci Rep 2017 Aug 31;7(1):10220. Epub 2017 Aug 31.
    Institute of Biomedicine and Translational Medicine, Department of Physiology, University of Tartu, 19 Ravila Street, Tartu, 50411, Estonia.
    Wolfram syndrome (WS) is a rare autosomal-recessive disorder that is caused by mutations in the WFS1 gene and is characterized by juvenile-onset diabetes, optic atrophy, hearing loss and a number of other complications. Here, we describe the creation and phenotype of Wfs1 mutant rats, in which exon 5 of the Wfs1 gene is deleted, resulting in a loss of 27 amino acids from the WFS1 protein sequence. These Wfs1-ex5-KO232 rats show progressive glucose intolerance, which culminates in the development of diabetes mellitus, glycosuria, hyperglycaemia and severe body weight loss by 12 months of age. Read More

    Differences in characteristics of glucose intolerance between patients with NAFLD and chronic hepatitis C as determined by CGMS.
    Sci Rep 2017 Aug 31;7(1):10146. Epub 2017 Aug 31.
    Departments of Gastroenterology and Hepatology, Kochi Medical School, Kochi, Japan.
    Glucose intolerance frequently develops in accordance with the progression of chronic liver disease. However, differences in the characteristics of glucose intolerance between patients with nonalcoholic fatty liver disease (NAFLD) and those with chronic hepatitis C (C-CH) remain incompletely understood. To clarify these differences, patients with NAFLD (n = 37) and C-CH (n = 40) were evaluated with a continuous glucose monitoring system (CGMS). Read More

    Prior Endurance Training Enhances Beta-Adrenergic Signaling in Epidydimal Adipose from Mice Fed a High-Fat Diet.
    Obesity (Silver Spring) 2017 Aug 31. Epub 2017 Aug 31.
    Department of Health Sciences, Brock University, St. Catharines, Ontario, Canada.
    Objective: Adipose tissue beta-adrenergic signaling is attenuated in obesity and insulin resistance. It has been previously demonstrated that prior exercise training protects against short-term, high-fat diet (HFD)-induced weight gain and glucose intolerance. This study aimed to determine whether prior exercise training results in altered beta-adrenergic and lipolytic signaling in adipose tissue when challenged with a HFD. Read More

    Comparison of a point-of-care analyser for the determination of HbA1c with HPLC method.
    Pract Lab Med 2017 Aug 4;8:26-29. Epub 2017 Apr 4.
    Diabetes Research Unit Cymru, Grove Building, Swansea University, Swansea SA2 8PP, UK.
    Aims: As the use of Point of Care Testing (POCT) devices for measurement of glycated haemoglobin (HbA1c) increases, it is imperative to determine how their performance compares to laboratory methods. This study compared the performance of the automated Quo-Test POCT device (EKF Diagnostics), which uses boronate fluorescence quenching technology, with a laboratory based High Performance Liquid Chromatography (HPLC) method (Biorad D10) for measurement of HbA1c.

    Methods: Whole blood EDTA samples from subjects (n=100) with and without diabetes were assayed using a BioRad D10 and a Quo-Test analyser. Read More

    Eplerenone prevented obesity-induced inflammasome activation and glucose intolerance.
    J Endocrinol 2017 Aug 30. Epub 2017 Aug 30.
    T Sasaoka, Department of Clinical Pharmacology, University of Toyama, Toyama, 9300194, Japan
    Obesity-associated activation of the renin-angiotensin-aldosterone system is implicated in the pathogenesis of insulin resistance; however, influences of mineralocorticoid receptor (MR) inhibition remain unclear. Therefore, we aimed to clarify the anti-inflammatory mechanisms of MR inhibition using eplerenone, a selective MR antagonist, in C57BL/6 mice fed a high-fat diet (HFD) for 12 weeks. Eplerenone prevented excessive body weight gain and fat accumulation, ameliorated glucose intolerance and insulin resistance, and enhanced energy metabolism. Read More

    IgG is elevated in obese white adipose tissue but does not induce glucose intolerance via Fcγ-receptor or complement.
    Int J Obes (Lond) 2017 Aug 30. Epub 2017 Aug 30.
    Einthoven Laboratory for Experimental Vascular Medicine, Leiden, The Netherlands.
    Background: In obesity, B cells accumulate in white adipose tissue (WAT) and produce IgG, which may contribute to the development of glucose intolerance. IgG signals by binding to Fcγ receptors (FcγR) and by activating the complement system. The aim of our study was to investigate whether activation of FcγR and/or complement C3 mediates the development of high fat diet-induced glucose intolerance. Read More

    SCP4 Promotes Gluconeogenesis through FoxO1/3a Dephosphorylation.
    Diabetes 2017 Aug 29. Epub 2017 Aug 29.
    Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX 77030, USA.
    FoxO1 and FoxO3a (collectively FoxO1/3a) proteins regulate a wide array of cellular processes including hepatic gluconeogenesis. Phosphorylation of FoxO1/3a is a key event that determines its subcellular location and transcriptional activity. During glucose synthesis, the activity of FoxO1/3a is negatively regulated by Akt-mediated phosphorylation, which leads to the cytoplasmic retention of FoxO1/3a. Read More

    Maternal diabetes impairs the initiation of meiosis in murine female germ cells.
    Mol Med Rep 2017 Oct 14;16(4):5189-5194. Epub 2017 Aug 14.
    Reproductive Medical Center, Nanjing Jinling Hospital, Nanjing University School of Medicine, Nanjing, Jiangsu 210002, P.R. China.
    Gestational diabetes mellitus (GDM) is characterized by an initial diagnosis of glucose intolerance during pregnancy. There is increasing evidence supporting the association between GDM and the inhibited development of several organs in offspring. In the present study, a murine GDM model was established in mice by intraperitoneal injection of streptozotocin to evaluate the effect of maternal diabetes on the initiation of meiosis in female germ cells of offspring. Read More

    Effect of Magnesium Supplements on Insulin Secretion After Kidney Transplantation: A Randomized Controlled Trial.
    Ann Transplant 2017 Aug 29;22:524-531. Epub 2017 Aug 29.
    Renal Division, Department of Internal Medicine, Ghent University Hospital, Ghent, Belgium.
    BACKGROUND Hypomagnesemia is associated with a disturbed glucose metabolism. Insulin hypo-secretion predicts diabetes in the general population and in transplant recipients. We aimed to assess whether magnesium improves insulin secretion and glycemic control after transplantation in prevalent hypomagnesemic kidney transplant recipients. Read More

    Novel Insights in the Metabolic Syndrome in Childhood and Adolescence.
    Horm Res Paediatr 2017 Aug 28. Epub 2017 Aug 28.
    Hospital for Children and Adolescents, Centre for Pediatric Research, Department Woman and Child Health, University of Leipzig, Leipzig, Germany.
    Metabolic syndrome (MetS) is recognized as an escalating major health risk in adults as well as in children and adolescents. Its prevalence ranges from 6 to 39% depending on the applied definition criteria. To date, there is no consensus on a MetS definition for children and adolescents. Read More

    Cannabinoid CB1 receptor inverse agonist MJ08 stimulates glucose production via hepatic sympathetic innervation in rats.
    Eur J Pharmacol 2017 Aug 26. Epub 2017 Aug 26.
    Beijing Institute of Pharmacology and Toxicology, Beijing 100850, PR China; State Key Laboratory of Toxicology and Medical Countermeasures, Beijing 100850, China. Electronic address:
    As a key insulin target tissue for maintaining systemic glucose homeostasis, the liver plays important roles in improving obesity-associated insulin intolerance via selective cannabinoid CB1 receptor antagonism/inverse agonism. However, it is unclear whether this receptor inverse agonism affects hepatic glucose metabolism. MJ08 is a novel cannabinoid CB1 receptor antagonist/inverse agonist that has superior inverse agonism over the well-known antagonist/inverse agonist, SR141716 (rimonabant). Read More

    Incorporating Refractory Period in Mechanical Stimulation Mitigates Obesity-Induced Adipose Tissue Dysfunction in Adult Mice.
    Obesity (Silver Spring) 2017 Aug 25. Epub 2017 Aug 25.
    Department of Biomedical Engineering, Stony Brook University, Stony Brook, New York, USA.
    Objective: The aim of this study was to determine whether inclusion of a refractory period between bouts of low-magnitude mechanical stimulation (LMMS) can curb obesity-induced adipose tissue dysfunction and sequelae in adult mice.

    Methods: A diet-induced obesity model that included a diet with 45% of kilocalories from fat was employed with intention to treat. C57BL/6J mice were weight matched into four groups: low-fat diet (LFD, n = 8), high-fat diet (HFD, n = 8), HFD with one bout of 30-minute LMMS (HFDv, n = 9), and HFD with two bouts of 15-minute LMMS with a 5-hour separation (refractory period, RHFDv, n = 9). Read More

    The Effects of Duodenojejunal Omega Switch in Combination with High-Fat Diet and Control Diet on Incretins, Body Weight, and Glucose Tolerance in Sprague-Dawley Rats.
    Obes Surg 2017 Aug 24. Epub 2017 Aug 24.
    Clinic of General, Visceral, Transplantation and Vascular Surgery, Hospital of the Ludwig Maximilian University, Munich, Germany.
    Background: Despite excellent results of bariatric surgery in the treatment of type 2 diabetes and weight loss in human subjects, some patients do not obtain desired results. One of the reasons for this is that not all patients follow caloric intake recommendations.

    Aim: The aim of this study was to investigate the effect of duodenojejunal omega switch (DJOS) surgery on body weight, glucose tolerance, and incretins in rats. Read More

    Curcumin limits weight gain, adipose tissue growth, and glucose intolerance following the cessation of exercise and caloric restriction in rats.
    J Appl Physiol (1985) 2017 Aug 24:jap.01115.2016. Epub 2017 Aug 24.
    York University
    Weight regain, adipose tissue growth, and insulin resistance can occur within days after the cessation of regular dieting and exercise. We investigated the effect of curcumin on preserving metabolic health and limiting adipose tissue growth following the cessation of daily exercise and caloric restriction (CR). Sprague-Dawley rats (6-7 wks old) underwent a 'training' protocol of 24 hr voluntary running wheel access and CR (15-20 g/day) for 3 wks ('All Trained') or were sedentary and fed ad libitum ('Sed'). Read More

    Essential Role of Interleukin-12 in Angiogenesis in Type 2 Diabetes.
    Am J Pathol 2017 Aug 21. Epub 2017 Aug 21.
    Department of Physiological Science, Eastern Virginia Medical School, Norfolk, Virginia. Electronic address:
    Recently interleukin-12 (IL-12) emerged as a critical player in type 2 diabetes complications. We previously reported that ischemia-induced angiogenesis is compromised in type 2 diabetic mice. In this study, we determined that IL-12 disruption rescued angiogenesis and arteriogenesis in type 2 diabetic mice. Read More

    Prevalence of type 2 diabetes and impaired fasting glucose in patients affected by rheumatoid arthritis: Results from a cross-sectional study.
    Medicine (Baltimore) 2017 Aug;96(34):e7896
    aDivision of Rheumatology, Department of Biotechnological and Applied Clinical Science, University of L'Aquila, L'Aquila bDepartment of Health Sciences, University of Catanzaro "Magna Graecia", Catanzaro cDivision of Rheumatology, Department of Internal Medicine, University of Palermo, Palermo, Italy.
    Although the better management of rheumatoid arthritis (RA) has significantly improved the long-term outcome of affected patients, a significant proportion of these may develop associated comorbidities including cardiometabolic complications. However, it must be pointed out that a comprehensive cardiometabolic evaluation is still poorly integrated into the management of RA patients, due to a limited awareness of the problem, a lack of appropriate clinical studies, and optimal strategies for cardiovascular (CV) risk reduction in RA. In addition, although several studies investigated the possible association between traditional CV risk factors and RA, conflicting results are still available. Read More

    Weight loss enhances hepatic antioxidant status in a NAFLD model induced by high fat diet.
    Appl Physiol Nutr Metab 2017 Aug 23. Epub 2017 Aug 23.
    Universidade do Estado do Rio de Janeiro, 28130, Pharmacology and Psychobiology, Rio de Janeiro, Rio de Janeiro, Brazil ;
    Purpose: Nonalcoholic fatty liver disease (NAFLD) is a benign condition that can progress to more severe liver damage in a process mediated, in part, by disturbances in redox balance. Additionally, some argue that it is set to become the main cause of end-stage liver disease in the near future. Here, we investigated whether a diet-induced weight loss is able to reverse hepatic lipid accumulation and to reduce oxidative stress in liver from C57BL/6 mice fed a high-fat (HF) diet. Read More

    The impact of ageing, fasting and high-fat diet on central and peripheral glucose tolerance and glucose-sensing neural networks in the arcuate nucleus.
    J Neuroendocrinol 2017 Aug 23. Epub 2017 Aug 23.
    Metabolic Disease and Obesity Program, Biomedicine Discovery Institute, Monash University, Australia.
    Obesity and aging are risk factors for diabetes. Here we investigated effects of aging, obesity and fasting on central and peripheral glucose tolerance and on glucose-sensing neuronal function in the arcuate nucleus of rats, with a view to providing insight into central mechanisms regulating glucose homeostasis and how they change or are subject to dysfunction with aging and obesity. We show that following a glucose load, central glucose tolerance at the level of the cerebrospinal fluid (CSF) and plasma is significantly reduced in rats maintained on high fat diet (HFD). Read More

    Different strategies for diagnosing gestational diabetes to improve maternal and infant health.
    Cochrane Database Syst Rev 2017 08 23;8:CD007122. Epub 2017 Aug 23.
    Maternal and Child Health, Bradford Institute for Health Research, Bradford Royal Infirmary, Duckworth Lane, Bradford, UK, BD9 6RJ.
    Background: Gestational diabetes mellitus (GDM) is carbohydrate intolerance resulting in hyperglycaemia with onset or first recognition during pregnancy. If untreated, perinatal morbidity and mortality may be increased. Accurate diagnosis allows appropriate treatment. Read More

    Ccdc3: A New P63 Target Involved in Regulation Of Liver Lipid Metabolism.
    Sci Rep 2017 Aug 21;7(1):9020. Epub 2017 Aug 21.
    Department of Biochemistry & Molecular Biology and Tulane Cancer Center, Tulane University School of Medicine, New Orleans, LA, 70112, USA.
    TAp63, a member of the p53 family, has been shown to regulate energy metabolism. Here, we report coiled coil domain-containing 3 (CCDC3) as a new TAp63 target. TAp63, but not ΔNp63, p53 or p73, upregulates CCDC3 expression by directly binding to its enhancer region. Read More

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