16,578 results match your criteria Glucose Intolerance


Switch to rilpivirine improves diabetes in an elderly HIV-positive patient.

Infez Med 2019 Mar;27(1):103-105

Clinic of Infectious Diseases, Department of Medicine and Science of Aging, University "G. d'Annunzio" Chieti-Pescara, Italy.

Glucose intolerance and diabetes are becoming increasingly common in HIV-infected patients in the cART era. Many factors are associated with the development of diabetes in HIV-infected individuals who receive cART, one of which is the assumption of specific antiretroviral classes or agents. We describe a case in a 72-year-old Caucasian man with long-term HIV infection. Read More

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Continuous feeding of a combined high-fat and high-sucrose diet, rather than an individual high-fat or high-sucrose diet, rapidly enhances the glucagon-like peptide-1 secretory response to meal ingestion in diet-induced obese rats.

Nutrition 2019 Jan 11;62:122-130. Epub 2019 Jan 11.

Graduate School of Agriculture, Hokkaido University, Sapporo, Japan; Research Faculty of Agriculture, Hokkaido University, Sapporo, Japan.

Objectives: Glucagon-like peptide-1 (GLP-1) is secreted by enteroendocrine L-cells in response to nutrient ingestion. To date, GLP-1 secretion in diet-induced obesity is not well characterized. We aimed to examine GLP-1 secretion in response to meal ingestion during the progression of diet-induced obesity and determinewhether a combined high-fat and high-sucrose (HFS) diet, an individual high-fat (HiFat), or a high-sucrose (HiSuc) diet affect adaptive changes in the postprandial GLP-1 response. Read More

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http://dx.doi.org/10.1016/j.nut.2019.01.004DOI Listing
January 2019

Acute hyperglycemia increases renal tissue oxygenation as measured by BOLD-MRI in healthy overweight volunteers.

Diabetes Res Clin Pract 2019 Mar 11;150:138-143. Epub 2019 Mar 11.

Service of Nephrology and Hypertension, University Hospital Lausanne (CHUV), Switzerland. Electronic address:

Aim: Animal studies have suggested that acute hyperglycemia induces transient renal hypoxia and kidney damage, yet this has not been tested in humans. Therefore, we assessed in human subjects the effect of acute hyperglycemia on renal tissue oxygenation as measured with blood oxygenation level-dependent magnetic resonance imaging (BOLD-MRI).

Methods: In this single center prospective interventional study, healthy overweight subjects were recruited. Read More

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http://dx.doi.org/10.1016/j.diabres.2019.03.009DOI Listing

Transitioning from Infertility-Based (ART 1.0) to Elective (ART 2.0) Use of Assisted Reproductive Technologies and the DOHaD Hypothesis: Do We Need to Change Consenting?

Semin Reprod Med 2018 May 13;36(3-04):204-210. Epub 2019 Mar 13.

Division or Reproductive Endocrinology, Department of Obstetrics, Gynecology and Reproductive Sciences, University of California San Francisco, San Francisco, California.

The use of assisted reproductive technologies (ARTs) has increased significantly in recent years. While this is partially due to improved access for infertile patients, another contribution to the growth of ART utilization is represented by individuals without infertility, who electively chose to freeze their gametes and embryos for future use, before ever attempting conception spontaneously. Overall, the safety of ART for parents and children is well described and the risks are modest. Read More

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http://dx.doi.org/10.1055/s-0038-1677526DOI Listing
May 2018
1 Read

Simvastatin inhibits L-type Ca2+-channel activity through impairment of mitochondrial function.

Toxicol Sci 2019 Mar 11. Epub 2019 Mar 11.

School of Life Sciences, University of Nottingham, Nottingham, UK.

Plasma membrane ion channels and mitochondrial electron transport complexes (mETC) are recognised "off-targets" for certain drugs. Simvastatin is one such drug, a lipophilic statin used to treat hypercholesterolaemia, but which is also associated with adverse effects like myopathy and increased risk of glucose intolerance. Such myopathy is thought to arise through adverse actions of simvastatin on skeletal muscle mETC and mitochondrial respiration. Read More

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http://dx.doi.org/10.1093/toxsci/kfz068DOI Listing

Reversal of a Treatment-Resistant, Depression-Related Brain State with the Kv7 Channel Opener Retigabine.

Neuroscience 2019 Mar 8. Epub 2019 Mar 8.

Department of Biology, Pennsylvania State University, University Park, PA 16802; Department of Biochemistry & Molecular Biology, Pennsylvania State University, University Park, PA 16802; Center for Molecular Investigation of Neurological Disorders (CMIND), The Huck Institutes of the Life Sciences, Pennsylvania State University, University Park, PA 16802. Electronic address:

Neuroinflammation is associated with increased vulnerability to diverse psychiatric conditions, including treatment-resistant major depressive disorder (MDD). Here we assessed whether high fat diet (HFD) induced neuroinflammation may be suitable to model a treatment-resistant depressive-like brain state in mice. Male and female mice were fed a HFD for 18 weeks, followed by quantitation of glucose tolerance, inflammatory markers of brain tissue (TNFα, IL-6, IL-1β, Iba-1), neural excitability in the prelimbic cortex (PLC), as well as assessment of emotional reactivity and hedonic behavior in a battery of behavioral tests. Read More

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http://dx.doi.org/10.1016/j.neuroscience.2019.03.003DOI Listing

High Carbohydrate High Fat Diet Induced Hepatic Steatosis and Dyslipidemia Were Ameliorated by Leaf Powder Supplementation in Rats.

Evid Based Complement Alternat Med 2019 3;2019:1897237. Epub 2019 Feb 3.

Department of Pharmaceutical Sciences, North South University, Bangladesh.

leaf is reported to contain many bioactive polyphenols which play an important role in the prevention and treatment of various diseases. Our investigation aimed to study the effect of leaf powder supplementation on obesity and liver status by using experimental rats. To study the effects of guava leaf supplementation in high fat diet induced obesity, rats were randomly divided into four experimental groups (n=7), control (group I), control + guava leaf (group II), HCHF (group III), and HCHF + guava leaf (group IV). Read More

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https://www.hindawi.com/journals/ecam/2019/1897237/
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http://dx.doi.org/10.1155/2019/1897237DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6378023PMC
February 2019
1 Read
1.880 Impact Factor

Decrease of FGF19 contributes to the increase of fasting glucose in human in an insulin-independent manner.

J Endocrinol Invest 2019 Mar 9. Epub 2019 Mar 9.

Shanghai Key Laboratory of Diabetes Mellitus, Department of Endocrinology and Metabolism, Shanghai Diabetes Institute, Shanghai Clinical Center for Diabetes, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, 600 Yishan Road, Shanghai, 200233, China.

Purpose: The ileum-derived fibroblast growth factor 19 (FGF19) plays key roles in hepatic glucose homeostasis in animals in an insulin-independent manner. Here, we analyzed the association of FGF19 with glucose effectiveness (GE, the insulin-independent glucose regulation), as well as hepatic glucose production (HGP) in Chinese subjects.

Methods: GE was measured by frequently sampled intravenous glucose tolerance test (FSIVGTT) in normal glucose tolerance (NGT), isolated-impaired glucose tolerance (I-IGT), and isolated-impaired fasting glucose (I-IFG) subjects. Read More

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http://dx.doi.org/10.1007/s40618-019-01018-5DOI Listing
March 2019
2 Reads

Effect of annatto-extracted tocotrienols and green tea polyphenols on glucose homeostasis and skeletal muscle metabolism in obese male mice.

J Nutr Biochem 2019 Feb 10;67:36-43. Epub 2019 Feb 10.

Department of Pathology, Texas Tech University Health Sciences Center, Lubbock, TX; Center of Excellence for Integrative Health, Texas Tech University Health Sciences Center, Lubbock, TX; Obesity Research Cluster, Texas Tech University, Lubbock, TX. Electronic address:

Skeletal muscle is the major site for glucose uptake and thus plays an important role in initiating insulin resistance in type 2 diabetes mellitus. This study evaluated the effects of tocotrienols (TT) and green tea polyphenols (GTP) individually or in combination on glucose homeostasis and skeletal muscle metabolism in obese mice with insulin resistance and elevation of blood glucose. Forty-eight male mice were fed a high-fat diet and assigned to 4 groups in a 2 (no TT vs. Read More

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http://dx.doi.org/10.1016/j.jnutbio.2019.01.021DOI Listing
February 2019
1 Read

Prolonged inorganic arsenic exposure via drinking water impairs brown adipose tissue function in mice.

Sci Total Environ 2019 Mar 2;668:310-317. Epub 2019 Mar 2.

Program of Environmental Toxicology, School of Public Health, China Medical University, No 77 Puhe Road, Shenyang North New Area, Shenyang, Liaoning 110122, PR China. Electronic address:

Although epidemiologic studies show an association between long-term environmental inorganic arsenic (iAs) exposure and various disorders of glucose and lipid metabolism, the mechanisms of these ailments remain unclear. While white adipose tissue (WAT) essentially acts as a storage tissue for energy and is key to energy homeostasis, brown adipose tissue (BAT) consumes excess energy via uncoupling protein 1-mediated non-shivering thermogenesis in mitochondria and helps maintain the steady state of glucose and lipid metabolism. Our previous in vitro work found that iAs may inhibit adipogenesis and glucose uptake in adipocytes, leading us to hypothesize that chronic exposure to iAs in vivo may also affect the development and function of BAT, which plays a part in iAs-induced metabolic disorders. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2019.03.008DOI Listing

Associations between birth weight and glucose intolerance in adulthood among Greenlandic Inuit.

Diabetes Res Clin Pract 2019 Mar 6;150:129-137. Epub 2019 Mar 6.

Steno Diabetes Center Copenhagen, Gentofte, Denmark.

Aims: To examine the association between birth weight and glucose intolerance in adult Greenlandic Inuit.

Methods: We examined 1429 participants aged 18-56 years from two population-based, cross-sectional studies in Greenland with information on birth weight. Oral glucose tolerance tests, anthropometric measures and ultrasound of abdominal tissue were performed. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01688227183142
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http://dx.doi.org/10.1016/j.diabres.2019.03.005DOI Listing
March 2019
3 Reads

Pck-ing up steam: Widening the salmonid gluconeogenic gene duplication trail.

Gene 2019 Mar 5;698:129-140. Epub 2019 Mar 5.

Department of Biology, University of Ottawa, Ottawa, Ontario K1N 6N5, Canada. Electronic address:

Rainbow trout have, as salmonid fish species, undergone sequential genome duplication events in their evolutionary history. In addition to a teleost-specific whole genome duplication approximately 320-350 million years ago, rainbow trout and salmonids in general underwent an additional salmonid lineage-specific genome duplication event approximately 80 million years ago. Through the recent sequencing of salmonid genome sequences, including the rainbow trout, the identification and study of duplicated genes has become available. Read More

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http://dx.doi.org/10.1016/j.gene.2019.02.079DOI Listing

Peptide vaccine for semaphorin3E ameliorates systemic glucose intolerance in mice with dietary obesity.

Sci Rep 2019 Mar 7;9(1):3858. Epub 2019 Mar 7.

Department of Cardiovascular Biology and Medicine, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.

We previously demonstrated that cellular aging signals upregulated a secreted class 3 semaphorin E (Sema3E) and its receptor plexinD1 in the adipose tissue of a murine model of dietary obesity and that Sema3E was a chemoattractant, mediating its biological effects by inducing infiltration of plexinD1-positive inflammatory macrophages into the visceral white adipose tissue. This study was performed to develop a peptide vaccine for Sema3E and test its therapeutic potential in a murine model of dietary obesity. Two antigenic peptides were selected to generate neutralizing antibodies for a vaccine. Read More

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http://dx.doi.org/10.1038/s41598-019-40325-yDOI Listing

Systems Genetics of Hepatic Metabolome Reveals Octopamine as a Target for Non-Alcoholic Fatty Liver Disease Treatment.

Sci Rep 2019 Mar 6;9(1):3656. Epub 2019 Mar 6.

Sorbonne University, University Paris Descartes, University Paris Diderot, INSERM UMR_S 1138, Cordeliers Research Centre, 75006, Paris, France.

Non-alcoholic fatty liver disease (NAFLD) is often associated with obesity and type 2 diabetes. To disentangle etiological relationships between these conditions and identify genetically-determined metabolites involved in NAFLD processes, we mapped H nuclear magnetic resonance (NMR) metabolomic and disease-related phenotypes in a mouse F2 cross derived from strains showing resistance (BALB/c) and increased susceptibility (129S6) to these diseases. Quantitative trait locus (QTL) analysis based on single nucleotide polymorphism (SNP) genotypes identified diet responsive QTLs in F2 mice fed control or high fat diet (HFD). Read More

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http://www.nature.com/articles/s41598-019-40153-0
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http://dx.doi.org/10.1038/s41598-019-40153-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6403227PMC
March 2019
2 Reads

Methionine restriction prevents onset of type 2 diabetes in NZO mice.

FASEB J 2019 Mar 6:fj201900150R. Epub 2019 Mar 6.

Department of Experimental Diabetology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany.

Dietary methionine restriction (MR) is well known to reduce body weight by increasing energy expenditure (EE) and insulin sensitivity. An elevated concentration of circulating fibroblast growth factor 21 (FGF21) has been implicated as a potential underlying mechanism. The aims of our study were to test whether dietary MR in the context of a high-fat regimen protects against type 2 diabetes in mice and to investigate whether vegan and vegetarian diets, which have naturally low methionine levels, modulate circulating FGF21 in humans. Read More

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http://dx.doi.org/10.1096/fj.201900150RDOI Listing

The pseudokinase MLKL regulates hepatic insulin sensitivity independently of inflammation.

Mol Metab 2019 Feb 20. Epub 2019 Feb 20.

Division of Endocrinology and Metabolism, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University and Collaborative Innovation Center of Biotherapy, Chengdu 610041, Sichuan, China. Electronic address:

Objective: The mixed lineage kinase domain like (MLKL) protein, receptor interacting protein (RIPK) 1, and RIPK3 are key regulators of necroptosis, a highly pro-inflammatory mode of cell death that has been implicated in various pathological processes and human diseases. However, the role of these necroptotic regulators in diabetes remains unknown. Here we sought to delineate the role of MLKL in insulin resistance and type 2 diabetes (T2D). Read More

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http://dx.doi.org/10.1016/j.molmet.2019.02.003DOI Listing
February 2019
2 Reads

The Impact of GPR1 Signaling on Maternal High-fat Feeding and Placenta Metabolism in Mice.

Am J Physiol Endocrinol Metab 2019 Mar 5. Epub 2019 Mar 5.

Research Laboratory of Reproductive Health, Shenzhen Institutes of Advanced and Technology, Chinese Academy of Sciences, Shenzhen 518055, China.

Chemerin and GPR1 are increased on serum and placenta in mice during pregnancy. Interestingly, we observed increased serum chemerin levels and decreased GPR1 expression in HFD-fed mice placental compared to chow at gestational day 18(D18). GPR1 protein and gene levels were significantly decreased in GDM patient placentas. Read More

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http://dx.doi.org/10.1152/ajpendo.00437.2018DOI Listing
March 2019
3 Reads
3.785 Impact Factor

Hypothalamic inflammation and obesity: a mechanistic review.

Arch Pharm Res 2019 Mar 5. Epub 2019 Mar 5.

Department of Oral Biology, Yonsei University College of Dentistry, BK21 PLUS, Seoul, 03722, Korea.

Obesity is one of the worldwide prevalent disease caused by the imbalance between food intake and energy expenditure. Over a 100 years of research demonstrate that hypothalamus is the critical brain region regulating energy homeostasis, and evidences suggest the participation of non-neuronal populations such as astrocytes and microglia in the regulation of energy homeostasis. Recently, fat-rich diet induced hypothalamic inflammation has been found to deregulate the energy homeostasis, leading to the insulin resistance, glucose intolerance, and obesity. Read More

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http://dx.doi.org/10.1007/s12272-019-01138-9DOI Listing

Prebiotics from acorn and sago prevent high-fat-diet-induced insulin resistance via microbiome-gut-brain axis modulation.

J Nutr Biochem 2019 Jan 30;67:1-13. Epub 2019 Jan 30.

Department of Internal Medicine-Molecular Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA; Department of Microbiology and Immunology, Wake Forest School of Medicine, Winston-Salem, NC, USA. Electronic address:

Role of gut microbiome in obesity and type 2 diabetes (T2D) became apparent from several independent studies indicating that gut microbiome modulators like prebiotics may improve microbiome perturbations (dysbiosis) to ameliorate metabolic derangements. We herein isolate water soluble, nondigestible polysaccharides from five plant-based foods (acorn, quinoa, sunflower, pumpkin seeds and sago) and assess their impact on human fecal microbiome and amelioration of high-fat-diet (HFD)-induced obesity/T2D in mice. During polysaccharide isolation, purification, biochemical and digestion resistance characterization, and fermentation pattern by human fecal microbiome, we select acorn- and sago-derived prebiotics (on the basis of relatively higher purity and yield and lower protein contamination) and examine their effects in comparison to inulin. Read More

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http://dx.doi.org/10.1016/j.jnutbio.2019.01.011DOI Listing
January 2019

Circulating Vascular Cell Adhesion Molecule-1 (VCAM-1) and Intercellular Adhesion Molecule-1 (ICAM-1): Relationship with carotid artery elasticity in patients with impaired glucose regulation (IGR).

Ann Endocrinol (Paris) 2019 Feb 7. Epub 2019 Feb 7.

Department of Blood Supply, Zaozhuang Central Blood Station, No. 44 Wenhuazhong Road Shizhong District, 277100 Zaozhuang, Shandong, China. Electronic address:

Objective: To investigate the relations of circulating adhesion molecule vascular cell adhesion molecule-1 (VCAM-1) and intercellular adhesion molecule-1 (ICAM-1) with carotid artery elasticity in patients with impaired glucose regulation (IGR).

Methods: A total of 208 subjects were enrolled from January 2013 to March 2014. One hundred forty-eight were IGR patients, and 60 had normal glucose tolerance (NGT). Read More

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http://dx.doi.org/10.1016/j.ando.2019.01.001DOI Listing
February 2019

Deletion of Robo4 prevents high fat diet induced adipose artery and systemic metabolic dysfunction.

Microcirculation 2019 Mar 1:e12540. Epub 2019 Mar 1.

University of Utah, Department of Internal medicine, Division of Geriatrics.

Objective: Accumulating evidence suggests the vascular endothelium plays a fundamental role in the pathophysiology of obesity by regulating the functional status of white adipose and systemic metabolism. Roundabout guidance 4 (Robo4) is expressed specifically in endothelial cells and increases vascular stability and inhibits angiogenesis. We sought to determine the role of Robo4 in modulating cardio-metabolic function in response to high fat feeding. Read More

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http://dx.doi.org/10.1111/micc.12540DOI Listing

Host genetics and diet composition interact to modulate gut microbiota and predisposition to metabolic syndrome in spontaneously hypertensive stroke-prone rats.

FASEB J 2019 Mar 1:fj201801627RRR. Epub 2019 Mar 1.

Department of Production Animal Health, Faculty of Veterinary Medicine, University of Calgary, Calgary, Alberta, Canada.

Metabolic syndrome encompasses obesity, glucose intolerance, hypertension, and dyslipidemia; however, the interactions between diet and host physiology that predispose to metabolic syndrome are incompletely understood. Here, we explored the effects of a high-fat diet (HFD) on energy balance, gut microbiota, and risk factors of metabolic syndrome in spontaneously hypertensive stroke-prone (SHRSP) and Wistar-Kyoto (WKY) rats. We found that the SHRSP rats were hypertensive, hyperphagic, less sensitive to hypophagic effects of exendin-4, and expended more energy with diminished sensitivity to sympathetic blockade compared to WKY rats. Read More

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http://dx.doi.org/10.1096/fj.201801627RRRDOI Listing
March 2019
2 Reads

Cross-talk between fetal membranes and visceral adipose tissue involves HMGB1-RAGE and VIP-VPAC2 pathways in human gestational diabetes mellitus.

Acta Diabetol 2019 Feb 28. Epub 2019 Feb 28.

Department of Experimental Medicine, Section of Medical Pathophysiology, Food Science and Endocrinology, Sapienza University of Rome, Rome, Italy.

Aims: Gestational diabetes mellitus (GDM) is defined as glucose intolerance that is first diagnosed during pregnancy. Maternal adipose tissue and fetal membranes secrete various molecules that are relevant players in the pathogenesis of GDM. This pilot study aimed to examine whether the expression of the high mobility group box 1 protein (HMGB1) and its receptor for advanced glycation end products (RAGE), and the vasoactive intestinal peptide (VIP) and its receptors (VPAC-1,-2) were modified in pregnant women with GDM. Read More

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http://dx.doi.org/10.1007/s00592-019-01304-xDOI Listing
February 2019
1 Read

Dietary iron interacts with genetic background to influence glucose homeostasis.

Nutr Metab (Lond) 2019 18;16:13. Epub 2019 Feb 18.

Department of Genetics, Washington University School of Medicine in Saint Louis, 660 South Euclid Ave, Saint Louis, MO 63110 USA.

Background: Iron is a critical component of metabolic homeostasis, but consumption of dietary iron has increased dramatically in the last 30 years, corresponding with the rise of metabolic disease. While the link between iron metabolism and metabolic health is well established, the extent to which dietary iron contributes to metabolic disease risk is unexplored. Further, it is unknown how dietary iron interacts with genetic background to modify metabolic disease risk. Read More

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http://dx.doi.org/10.1186/s12986-019-0339-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6380031PMC
February 2019

Hepatic Sdf2l1 controls feeding-induced ER stress and regulates metabolism.

Nat Commun 2019 Feb 27;10(1):947. Epub 2019 Feb 27.

Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo, Tokyo, 113-8655, Japan.

Dynamic metabolic changes occur in the liver during the transition between fasting and feeding. Here we show that transient ER stress responses in the liver following feeding terminated by Sdf2l1 are essential for normal glucose and lipid homeostasis. Sdf2l1 regulates ERAD through interaction with a trafficking protein, TMED10. Read More

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http://dx.doi.org/10.1038/s41467-019-08591-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6393527PMC
February 2019
2 Reads

Alteration of Bile Acid Metabolism by a High-Fat Diet Is Associated with Plasma Transaminase Activities and Glucose Intolerance in Rats.

J Nutr Sci Vitaminol (Tokyo) 2019 ;65(1):45-51

Laboratory of Nutritional Biochemistry, Research Group of Bioscience and Chemistry, Division of Fundamental Agriscience Research, Research Faculty of Agriculture, Hokkaido University.

Ingestion of a high-fat (HF) diet is known to enhance bile acid (BA) secretion, but precise information about the BA molecular species is lacking, especially information on the conjugated BAs in enterohepatic circulation. As cholesterol is the precursor of BAs, we analyzed alterations of the entire BA metabolic pathway in response to a HF diet without the addition of cholesterol and BA in the diet. Additionally, we evaluated the relationships between BA metabolism and some disorders, such as plasma transaminase activities and glucose intolerance induced by the HF diet. Read More

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http://dx.doi.org/10.3177/jnsv.65.45DOI Listing
January 2019
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Short-Term Low-Carbohydrate High-Fat Diet in Healthy Young Males Renders the Endothelium Susceptible to Hyperglycemia-Induced Damage, An Exploratory Analysis.

Nutrients 2019 Feb 26;11(3). Epub 2019 Feb 26.

School of Health and Exercise Sciences, University of British Columbia Okanagan, Kelowna, BC V1V 1V7, Canada.

Postprandial hyperglycemia has been linked to elevated risk of cardiovascular disease. Endothelial dysfunction and/or damage may be one of the mechanisms through which this occurs. In this exploratory study, we determined whether acute glucose ingestion would increase markers of endothelial damage/activation and impair endothelial function before and after a short-term low-carbohydrate high-fat diet (HFD) designed to induce relative glucose intolerance. Read More

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http://dx.doi.org/10.3390/nu11030489DOI Listing
February 2019

Maternal Supplementation with β-Carotene During Pregnancy Disturbs Lipid Metabolism and Glucose Homoeostasis in F1 Female Mice.

Mol Nutr Food Res 2019 Feb 27:e1900072. Epub 2019 Feb 27.

State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiamen University, Xiamen, 36110, P. R. China.

Scope: β-Carotene (BC), a substitute for vitamin A, is widely used for its benefits. The present study investigates whether in-utero BC administration can alter lipid and glucose homoeostasis in offspring.

Methods And Results: Pregnant mice are supplemented with BC (1 mg kg weight) by oral gavage once every 3 days, for a total of six doses. Read More

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http://dx.doi.org/10.1002/mnfr.201900072DOI Listing
February 2019
2 Reads

Are the changes in diagnostic criteria for gestational diabetes mellitus reflected in perinatal outcomes? A retrospective assessment.

Aust N Z J Obstet Gynaecol 2019 Feb 27. Epub 2019 Feb 27.

The Australian National University Medical School, Australian National University, Canberra, Australian Capital Territory, Australia.

Background: Gestational diabetes mellitus (GDM) is glucose intolerance first diagnosed during pregnancy not due to overt diabetes. Recent changes to the diagnostic guidelines have been shown to increase the apparent occurrence of GDM.

Aim: The aim of this study was to compare retrospectively the neonatal outcomes between groups defined using the new and old criteria to assess the impact of guideline changes on pregnancy outcomes. Read More

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http://dx.doi.org/10.1111/ajo.12956DOI Listing
February 2019

Polycystic Ovary Syndrome in Active Duty Service Women: A Retrospective Analysis.

Mil Med 2019 Feb 27. Epub 2019 Feb 27.

Graduate School of Nursing, Uniformed Services University, 4301 Jones Bridge Road, Bethesda, MD.

Introduction: Women make up 16.3% of the Department of Defense (DoD) active duty military population. January 2016, the Secretary of the Defense opened all military positions to women, including combat positions. Read More

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http://dx.doi.org/10.1093/milmed/usz023DOI Listing
February 2019
4 Reads

Associations of growth from birth to puberty with glycaemic indicators at ~17.5 years: evidence from Hong Kong's "Children of 1997" birth cohort.

Pediatr Diabetes 2019 Feb 25. Epub 2019 Feb 25.

School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, SAR, People's Republic of China.

Background: From an evolutionary biology perspective, where growth and reproduction trade-off against longevity, we assessed the associations of growth from birth to puberty by phase with later glycaemic indicators and any differences by sex.

Methods: In the population-representative Hong Kong Chinese "Children of 1997" birth cohort (n=8327), the relation of initial size (weight-for-age z score (WAZ) at birth, length/height-for-age z score (LAZ) at 3 months or body-mass-index-for-age z score (BAZ) at 3 months based on the World Health Organization growth standards/references) and growth at different phases (WAZ gains from 0 to 2 and 2 to 8 years, LAZ or BAZ gains from 3 months to 3 years, 3 to 8 years and 8 to 14 years) with fasting plasma glucose (FPG) and glycated hemoglobin (HbA1c) at ~17.5 years, was assessed using adjusted partial least squares regression. Read More

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http://dx.doi.org/10.1111/pedi.12838DOI Listing
February 2019
2.569 Impact Factor

Effects and Underlying Mechanisms of Bioactive Compounds on Type 2 Diabetes Mellitus and Alzheimer's Disease.

Oxid Med Cell Longev 2019 17;2019:8165707. Epub 2019 Jan 17.

Department of Nutrition, Dietetics, and Hospitality Management, Auburn University, Auburn, Alabama 36849, USA.

Type 2 diabetes mellitus is a complicated metabolic disorder characterized by hyperglycemia and glucose intolerance. Alzheimer's disease is a progressive brain disorder characterized by a chronic loss of cognitive and behavioral function. Considering the shared characteristics of both diseases, common therapeutic and preventive agents may be effective. Read More

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http://dx.doi.org/10.1155/2019/8165707DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360036PMC
March 2019
1 Read

Distinct Genetic and Functional Traits of Human Intestinal Prevotella copri Strains Are Associated with Different Habitual Diets.

Cell Host Microbe 2019 Mar 21;25(3):444-453.e3. Epub 2019 Feb 21.

Department of Agricultural Sciences, University of Naples Federico II, Portici, Italy; Task Force on Microbiome Studies, University of Naples Federico II, Naples, Italy. Electronic address:

The role of intestinal Prevotella species in human health is controversial, with both positive and negative associations. Strain-level diversity may contribute to discrepancies in genus and species associations with health and disease. We dissected the gut metagenomes of Italians with varying dietary habits, investigating the presence of distinct Prevotella copri strains. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S19313128193004
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http://dx.doi.org/10.1016/j.chom.2019.01.004DOI Listing
March 2019
7 Reads

Pancreatic prolactin receptor signaling regulates maternal glucose homeostasis.

J Endocrinol 2019 Feb 1. Epub 2019 Feb 1.

M Soares, Pathology, University of Kansas Medical Center, Kansas City, United States.

Prolactin (PRL) signaling has been implicated in the regulation of glucose homeostatic adaptations to pregnancy. In this report, the PRL receptor (Prlr) gene was conditionally disrupted in the pancreas, creating an animal model which proved useful for investigating the biology and pathology of gestational diabetes including its impacts on fetal and placental development. In mice, pancreatic PRLR signaling was demonstrated to be required for pregnancy-associated changes in maternal β cell mass and function. Read More

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http://dx.doi.org/10.1530/JOE-18-0518DOI Listing
February 2019

Superficial candidosis course in patients with carbohydrate metabolism disorder and diabetes mellitus.

Wiad Lek 2019 ;72(1):68-71

Danylo Halytsky Lviv National Medical University, Lviv, Ukraine.

Objective: Introduction: One of the pressing issues of modern dermatology is the prevalence of diseases of skin and mucous membranes caused by yeast-like fungi. The aim: To study specific features of the course of skin and mucous membranes superficial candidosis against the background of initial carbohydrate metabolism disorders or diabetes mellitus.

Patients And Methods: Materials and methods: We have examined 93 patients aged 18-75 suffering from superficial candidosis. Read More

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January 2019
1 Read

Functional peroxisomes are required for β-cell integrity in mice.

Mol Metab 2019 Feb 8. Epub 2019 Feb 8.

KU Leuven - University of Leuven, Department of Pharmaceutical and Pharmacological Sciences, Laboratory of Cell Metabolism, B-3000, Leuven, Belgium. Electronic address:

Objectives: Peroxisomes play a crucial role in lipid and reactive oxygen species metabolism, but their importance for pancreatic β-cell functioning is presently unknown. To examine the contribution of peroxisomal metabolism to β-cell homeostasis in mice, we inactivated PEX5, the import receptor for peroxisomal matrix proteins, in an inducible and β-cell restricted manner (Rip-Pex5 mice).

Methods: After tamoxifen-induced recombination of the Pex5 gene at the age of 6 weeks, mice were fed either normal chow or a high-fat diet for 12 weeks and were subsequently phenotyped. Read More

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http://dx.doi.org/10.1016/j.molmet.2019.02.001DOI Listing
February 2019

RDH1 suppresses adiposity by promoting brown adipose adaptation to fasting and re-feeding.

Cell Mol Life Sci 2019 Feb 20. Epub 2019 Feb 20.

Graduate Program in Metabolic Biology, Department of Nutritional Sciences and Toxicology, University of California, Berkeley, 119 Morgan Hall, Berkeley, CA, 94720-3104, USA.

RDH1 is one of the several enzymes that catalyze the first of the two reactions to convert retinol into all-trans-retinoic acid (atRA). Here, we show that Rdh1-null mice fed a low-fat diet gain more weight as adiposity (17% males, 13% females) than wild-type mice by 20 weeks old, despite neither consuming more calories nor decreasing activity. Glucose intolerance and insulin resistance develop following increased adiposity. Read More

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http://link.springer.com/10.1007/s00018-019-03046-z
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http://dx.doi.org/10.1007/s00018-019-03046-zDOI Listing
February 2019
4 Reads

Limited significance of repeated long-term radiological and hormonal examination in nonfunctioning adrenal incidentalomas.

Int Braz J Urol 2018 Dec 18;44. Epub 2018 Dec 18.

Division of Urology, Department of Regenerative and Transplant Medicine, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan.

Purpose: The purposes of the present study were to evaluate growth rate of nonfunctioning adrenal incidentalomas (AIs) and their development to hormonal hypersecretion on follow-up.

Materials And Methods: A retrospective study was conducted from the electronic medical records. A total of 314 patients were diagnosed with adrenal tumors between 2000 and 2016. Read More

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http://dx.doi.org/10.1590/S1677-5538.IBJU.2018.0235DOI Listing
December 2018
1 Read

Repercussions of low fructose-drinking water in male rats.

An Acad Bras Cienc 2019 Feb 14;91(1):e20170705. Epub 2019 Feb 14.

Laboratório de Fisiologia de Sistemas e Toxicologia Reprodutiva, Instituto de Ciências Biológicas e da Saúde, Universidade Federal de Mato Grosso/UFMT, Avenida Valdon Varjão, 6390, 78600-000 Barra do Garças, MT, Brazil.

Fructose consumption has increased worldwide, and it has been associated with the development of metabolic diseases such as insulin resistance (IR) and steatosis. The aim was to evaluate if lower fructose concentrations may cause pancreatic structural abnormalities, leading to a glucose intolerance without steatosis in male rats. Young male rats orally received 7% fructose solution for 12 weeks. Read More

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http://dx.doi.org/10.1590/0001-3765201920170705DOI Listing
February 2019
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Intestinal nerve cell injury occurs prior to insulin resistance in female mice ingesting a high-fat diet.

Cell Tissue Res 2019 Feb 18. Epub 2019 Feb 18.

Department of Biological Sciences, University of Idaho, 875 Perimeter Drive, LSS 252, Moscow, ID, 83844, USA.

Diabetic patients suffer from gastrointestinal disorders associated with dysmotility, enteric neuropathy and dysbiosis of gut microbiota; however, gender differences are not fully known. Previous studies have shown that a high-fat diet (HFD) causes type two diabetes (T2D) in male mice after 4-8 weeks but only does so in female mice after 16 weeks. This study seeks to determine whether sex influences the development of intestinal dysmotility, enteric neuropathy and dysbiosis in mice fed HFD. Read More

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http://dx.doi.org/10.1007/s00441-019-03002-0DOI Listing
February 2019
2 Reads

Hyperglycemia is associated with psoriatic inflammation in both humans and mice.

J Invest Dermatol 2019 Feb 15. Epub 2019 Feb 15.

Department of Immunology, Nagoya City University Graduate School of Medical Sciences, Nagoya 467-8601, Japan. Electronic address:

Chronic low-grade inflammation can cause several metabolic syndromes. Patients with psoriasis, a chronic immunological skin inflammation, often develop diabetes. However, it is not clear to date how psoriasis leads to, or is correlated with, glucose intolerance. Read More

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http://dx.doi.org/10.1016/j.jid.2019.01.029DOI Listing
February 2019
2 Reads

Long-Term Measures of Dyslipidemia, Inflammation, and Oxidative Stress in Rats Fed a High-Fat/High-Fructose Diet.

Lipids 2019 Jan 14;54(1):81-97. Epub 2019 Feb 14.

DMEM (Dynamique Musculaire & Métabolisme) INRA, University of Montpellier, 2 Place Viala, 34060, Montpellier, France.

Inflammation and oxidative stress are thought to be involved in, or associated with, the development of obesity, dyslipidemia, hepatic steatosis, and insulin resistance. This work was designed to determine the evolution of inflammation and oxidative stress during onset and progression of hepatic steatosis and glucose intolerance. Seventy-five male Wistar rats were divided to control and high-fat high-fructose (HFHFr) groups. Read More

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http://dx.doi.org/10.1002/lipd.12128DOI Listing
January 2019
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Prognostic factors of refractory NSCLC patients receiving anlotinib hydrochloride as the third- or further-line treatment.

Cancer Biol Med 2018 Nov;15(4):443-451

Department of Pulmonary Oncology, Tianjin Medical University Cancer Institute and Hospital, Tianjin 300060, China.

Objective: Anlotinib hydrochloride is a multitarget tyrosine kinase inhibitor that targets vascular endothelial growth factor receptor, fibroblast growth factor receptor, platelet-derived growth factor receptor, c-Kit, and c-MET; therefore, it exhibits both antitumor and anti-angiogenetic activities. A phase III trial has shown that anlotinib improved progression-free survival (PFS) and overall survival (OS) in patients with advanced non-small cell lung cancer (NSCLC), who presented with progressive disease or intolerance after standard chemotherapy. This study aimed to analyze the characteristics of patients receiving anlotinib treatment to determine the dominant populations who are fit for the treatment. Read More

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http://dx.doi.org/10.20892/j.issn.2095-3941.2018.0158DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372914PMC
November 2018
2 Reads

Insulin signaling in the hippocampus and amygdala regulates metabolism and neurobehavior.

Proc Natl Acad Sci U S A 2019 Feb 14. Epub 2019 Feb 14.

Section of Integrative Physiology and Metabolism, Joslin Diabetes Center, Boston, MA 02215;

Previous studies have shown that insulin and IGF-1 signaling in the brain, especially the hypothalamus, is important for regulation of systemic metabolism. Here, we develop mice in which we have specifically inactivated both insulin receptors (IRs) and IGF-1 receptors (IGF1Rs) in the hippocampus (Hippo-DKO) or central amygdala (CeA-DKO) by stereotaxic delivery of AAV-Cre into IR/IGF1R mice. Consequently, both Hippo-DKO and CeA-DKO mice have decreased levels of the GluA1 subunit of glutamate AMPA receptor and display increased anxiety-like behavior, impaired cognition, and metabolic abnormalities, including glucose intolerance. Read More

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http://dx.doi.org/10.1073/pnas.1817391116DOI Listing
February 2019

MD1 Deficiency Promotes Inflammatory Atrial Remodelling Induced by High-Fat Diets.

Can J Cardiol 2019 Feb 29;35(2):208-216. Epub 2018 Nov 29.

Department of Cardiology, Renmin Hospital of Wuhan University, Cardiovascular Research Institute of Wuhan University, and Hubei Key Laboratory of Cardiology, Hubei, China. Electronic address:

Background: Myeloid differentiation protein 1 (MD1) is expressed in various tissues, including the heart. However, the role of MD1 in obesity-related atrial remodelling remains incompletely understood. Here, this study intends to determine the regulatory role and underlying mechanisms of MD1 in obesity-related atrial remodelling. Read More

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http://dx.doi.org/10.1016/j.cjca.2018.11.020DOI Listing
February 2019
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Systematic thyroid screening in myotonic dystrophy: link between thyroid volume and insulin resistance.

Orphanet J Rare Dis 2019 02 13;14(1):42. Epub 2019 Feb 13.

CHU Lille, Endocrinology, Diabetology and Metabolism, F-59000, Lille, France.

Background: Myotonic dystrophy (DM1), a neuromuscular disease related to DMPK gene mutations, is associated to endocrine disorders and cancer. A routine endocrine work-up, including thyroid ultrasound (US), was conducted in 115 genetically-proven DM1 patients in a neuromuscular reference center. The aim of this study was to determine the prevalence and the causes of US thyroid abnormalities in DM1. Read More

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http://dx.doi.org/10.1186/s13023-019-1019-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6375124PMC
February 2019
2 Reads

A free-choice high-fat high-sucrose diet induces hyperphagia, obesity, and cardiovascular dysfunction in female cycling and pregnant rats.

Am J Physiol Regul Integr Comp Physiol 2019 Feb 13. Epub 2019 Feb 13.

Department of Physiology and Anatomy, University of North Texas Health Science Center, United States.

The main objective of these studies was to characterize metabolic, body composition, and cardiovascular responses to a free-choice high-fat high-sucrose diet in female cycling and pregnant rats. In the non-pregnant state, female Sprague-Dawley rats offered a 3-week free-choice high-fat high-sucrose diet had greater energy intake, adiposity, serum leptin and triglyceride concentrations compared to rats fed with standard chow, and developed glucose intolerance. In addition, choice diet-fed rats had larger cardiac ventricular weights, smaller kidney and pancreas weights, and higher blood pressure than chow-fed rats, but they did not exhibit resistance artery endothelial dysfunction. Read More

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http://dx.doi.org/10.1152/ajpregu.00391.2018DOI Listing
February 2019
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Exposure to Nanoscale Particulate Matter from Gestation to Adulthood Impairs Metabolic Homeostasis in Mice.

Sci Rep 2019 Feb 12;9(1):1816. Epub 2019 Feb 12.

Departments of Preventive Medicine and Biochemistry & Molecular Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, 90033, USA.

Emerging evidence from epidemiological and animal studies suggests that exposure to traffic-related air pollutants and particulate matter less than 2.5 µm in diameter (PM) contributes to development of obesity and related metabolic abnormalities. However, it is not known whether nanoscale particulate matter (nPM) with aerodynamic diameter ≤200 nm have similar adverse metabolic effects. Read More

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http://dx.doi.org/10.1038/s41598-018-37704-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372675PMC
February 2019
1 Read

WWOX somatic ablation in skeletal muscles alters glucose metabolism.

Mol Metab 2019 Jan 31. Epub 2019 Jan 31.

The Lautenberg Center for General and Tumor Immunology, Department of Immunology and Cancer Research-IMRIC, Hebrew University-Hadassah Medical School, Jerusalem, Israel; Department of Cancer Biology and Genetics, Wexner Medical Center, The Ohio State University, Columbus, OH, USA. Electronic address:

Objective: WWOX, a well-established tumor suppressor, is frequently lost in cancer and plays important roles in DNA damage response and cellular metabolism.

Methods: We re-analyzed several genome-wide association studies (GWAS) using the Type 2 Diabetes Knowledge Portal website to uncover WWOX's association with metabolic syndrome (MetS). Using several engineered mouse models, we studied the effect of somatic WWOX loss on glucose homeostasis. Read More

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http://dx.doi.org/10.1016/j.molmet.2019.01.010DOI Listing
January 2019