16,428 results match your criteria Glucose Intolerance


Retinal Deficits Precede Cognitive and Motor Deficits in a Rat Model of Type II Diabetes.

Invest Ophthalmol Vis Sci 2019 Jan;60(1):123-133

Atlanta VA Center for Visual and Neurocognitive Rehabilitation, Atlanta VA Health Care System, Decatur, Georgia, United States.

Purpose: To investigate the temporal appearance of retinal, cognitive, and motor deficits in Goto-Kakizaki (GK) rats, a spontaneously occurring, polygenic model of type II diabetes. GK rats develop impaired insulin secretion at 2 weeks and fasting hyperglycemia at 4 weeks.

Methods: In male and female GK rats and Wistar controls, glucose tolerance test (hyperglycemia) and electroretinogram (ERG, retinal function) were performed at 4 and 8 weeks of age. Read More

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http://dx.doi.org/10.1167/iovs.18-25110DOI Listing
January 2019

Copper in Glucose Intolerance, Cognitive Decline, and Alzheimer's Disease.

Alzheimer Dis Assoc Disord 2019 Jan 10. Epub 2019 Jan 10.

Department of Medicine, Diabetes Research Institute.

Trace metal dyshomeostasis has been linked to loss of cognitive performance. In particular, a disturbance in the regulation of copper (Cu), characterized by an increase in circulating Cu not bound to ceruloplasmin (non-Cp Cu), is thought to play a role in the development of Alzheimer disease (AD) and other neurodegenerative diseases in the aging population. Non-Cp Cu is redox active and its toxicity is thought to result from its ability to accelerate oxidative stress and advanced glycation endproduct (AGE) formation, leading to extracellular matrix damage in tissues including the brain. Read More

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http://dx.doi.org/10.1097/WAD.0000000000000280DOI Listing
January 2019

Nursing management of gestational diabetes mellitus in Ghana: Perspectives of nurse-midwives and women.

Midwifery 2019 Jan 4;71:19-26. Epub 2019 Jan 4.

Nelson Mandela University, Faculty of Health Sciences, Summerstrand, 6031, Port Elizabeth, South Africa. Electronic address:

Background: Gestational diabetes mellitus (GDM) is defined as any degree of glucose intolerance that is observed in the beginning of, or first acknowledged during pregnancy. The prevalence of GDM is estimated to be approximately 15% globally and is expected to increase due to growing numbers of overweight and obesity in women in their reproductive age. The nursing management of GDM in terms of lifestyle modifications (exercise, diet and nutrition) and the taking of diabetes medication, if required, and adherence thereto is crucial to prevent maternal and neonatal-perinatal complications. Read More

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http://dx.doi.org/10.1016/j.midw.2019.01.002DOI Listing
January 2019

Male and Female Intrauterine Growth-Restricted Offspring Differ in Blood Pressure, Renal Function, and Glucose Homeostasis Responses to a Postnatal Diet High in Fat and Sugar.

Hypertension 2019 Jan 14:HYPERTENSIONAHA11812134. Epub 2019 Jan 14.

From the Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson (S.I., J.H.D., J.M.J., A.D.B., B.T.A.).

It is well established that inadequate nutrition during fetal life followed by postnatal overabundance programs adiposity and glucose intolerance. Studies addressing sexual dimorphism in developmental responses to a dietary mismatch are limited; the effect on blood pressure and renal function is understudied. Therefore, this study tested the hypothesis that a mismatch of prenatal and postnatal nutrition heightens cardiorenal and metabolic risk, outcomes that may vary by sex. Read More

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.118.12134DOI Listing
January 2019

Fish Oil Protects Wild Type and Uncoupling Protein 1 Deficient Mice from Obesity and Glucose Intolerance by Increasing Energy Expenditure.

Mol Nutr Food Res 2019 Jan 11:e1800813. Epub 2019 Jan 11.

T. E. Oliveira, É. Castro, T. Belchior, M. L. Andrade, A. B. Chaves-Filho, A. S. Peixoto, M. F. Moreno, M. Ortiz Silva, R. J. Moreira, W. T. Festuccia, Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil, 05508-000.

Scope: We investigated the mechanisms and involvement of uncoupling protein 1 (UCP1) in the protection from obesity and insulin resistance induced by intake of high-fat diet rich in omega 3 (n-3) fatty acids.

Methods And Results: C57BL/6J mice were fed either a low-fat (control group) or one of two isocaloric high-fat diets containing either lard (HFD) or fish oil (HFN3) as fat source and evaluated for body weight, adiposity, energy expenditure, glucose homeostasis and inguinal white and interscapular brown adipose tissues (iWAT and iBAT, respectively) gene expression, lipidome and mitochondrial bioenergetics. HFN3 intake protected from obesity, glucose and insulin intolerances and hyperinsulinemia. Read More

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http://doi.wiley.com/10.1002/mnfr.201800813
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http://dx.doi.org/10.1002/mnfr.201800813DOI Listing
January 2019
1 Read

The antianginal ranolazine mitigates obesity-induced nonalcoholic fatty liver disease and increases hepatic pyruvate dehydrogenase activity.

JCI Insight 2019 Jan 10;4(1). Epub 2019 Jan 10.

Faculty of Pharmacy and Pharmaceutical Sciences.

Obese individuals are often at risk for nonalcoholic fatty liver disease (NAFLD), insulin resistance, type 2 diabetes (T2D), and cardiovascular diseases such as angina, thereby requiring combination therapies for their comorbidities. Ranolazine is a second-line antianginal agent that also improves glycemia, and our aim was to determine whether ranolazine modifies the progression of obesity-induced NAFLD. Twelve-week-old C57BL/6J male mice were fed a low-fat or high-fat diet for 10 weeks and then treated for 30 days with either vehicle control or ranolazine (50 mg/kg via daily s. Read More

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https://insight.jci.org/articles/view/124643
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http://dx.doi.org/10.1172/jci.insight.124643DOI Listing
January 2019
1 Read

Maternal urinary phthalate metabolites in relation to gestational diabetes and glucose intolerance during pregnancy.

Environ Int 2019 Feb 7;123:588-596. Epub 2019 Jan 7.

Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA, USA; Seattle Children's Research Institute, Seattle, WA, USA.

Background: Phthalates are common plasticizer chemicals that have been linked to glucose intolerance in the general population, but there is only limited research on their association with gestational diabetes (GDM).

Objective: We evaluated the association between 11 urinary phthalate metabolites and GDM, impaired glucose tolerance (IGT), and continuous blood glucose concentration during pregnancy in The Infant Development and Environment Study (TIDES). Based on prior study results, our primary analyses focused on monoethyl phthalate (MEP) in relation to our outcomes of interest. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01604120183249
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http://dx.doi.org/10.1016/j.envint.2018.12.021DOI Listing
February 2019
1 Read

Crocin ameliorates hepatic steatosis through activation of AMPK signaling in db/db mice.

Lipids Health Dis 2019 Jan 8;18(1):11. Epub 2019 Jan 8.

Department of Pharmacy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, NO.1277 Jiefang Avenue, Wuhan, 430022, China.

Background: Non-alcoholic fatty liver disease (NAFLD) is closely linked to obesity, type 2 diabetes and other metabolic disorders worldwide. Crocin is a carotenoid compound possessing various pharmacological activities. In the present study, we aimed to investigate the effect on fatty liver under diabetic and obese condition and to examine the possible role of AMP-activated protein kinase (AMPK) signaling. Read More

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https://lipidworld.biomedcentral.com/articles/10.1186/s12944
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http://dx.doi.org/10.1186/s12944-018-0955-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6325828PMC
January 2019
2 Reads

The islet-expressed Lhx1 transcription factor interacts with Islet-1 and contributes to glucose homeostasis.

Am J Physiol Endocrinol Metab 2019 Jan 8. Epub 2019 Jan 8.

Medicine, University of Alabama at Birmingham, United States.

The LIM-homeodomain (LIM-HD) transcription factor Islet-1 (Isl1) interacts with the LIM domain binding protein 1 (Ldb1) co-regulator to control expression of key pancreatic β-cell genes. However, Ldb1 also has Isl1-independent effects, supporting that another LIM-HD factor interacts with Ldb1 to impact β-cell development and/or function. LIM homeobox 1, or Lhx1, is an Isl1-related LIM-HD transcription factor that appears to be expressed in the developing mouse pancreas and in adult islets. Read More

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http://dx.doi.org/10.1152/ajpendo.00235.2018DOI Listing
January 2019

Mono-ADP-Ribosylhydrolase MACROD2 Is Dispensable for Murine Responses to Metabolic and Genotoxic Insults.

Front Genet 2018 12;9:654. Epub 2018 Dec 12.

International Clinical Research Center, St Anne's University Hospital, Brno, Czechia.

ADP-ribosylation is an important post-translational protein modification that regulates diverse biological processes, controlled by dedicated transferases, and hydrolases. Disruption in the gene encoding for MACROD2, a mono-ADP-ribosylhydrolase, has been associated to the Kabuki syndrome, a pediatric congenital disorder characterized by facial anomalies, and mental retardation. Non-coding and structural mutations/variations in MACROD2 have been associated to psychiatric disorders, to obesity, and to cancer. Read More

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https://www.frontiersin.org/article/10.3389/fgene.2018.00654
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http://dx.doi.org/10.3389/fgene.2018.00654DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6305994PMC
December 2018
2 Reads

Maternal High-Protein and Low-Protein Diets Perturb Hypothalamus and Liver Transcriptome and Metabolic Homeostasis in Adult Mouse Offspring.

Front Genet 2018 11;9:642. Epub 2018 Dec 11.

Department of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, CA, United States.

Early life nutritional imbalances are risk factors for metabolic dysfunctions in adulthood, but the long term effects of perinatal exposure to high versus low protein diets are not completely understood. We exposed C57BL/6J offspring to a high protein/low carbohydrate (HP/LC) or low protein/high carbohydrate (LP/HC) diet during gestation and lactation, and measured metabolic phenotypes between birth and 10 months of age in male offspring. Perinatal HP/LC and LP/HC exposures resulted in a decreased ability to clear glucose in the offspring, with reduced baseline insulin and glucose concentrations in the LP/HC group and a reduced insulin response post-glucose challenge in the HP/LC group. Read More

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https://www.frontiersin.org/article/10.3389/fgene.2018.00642
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http://dx.doi.org/10.3389/fgene.2018.00642DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6297185PMC
December 2018
1 Read

Incidence and contributing factors of glucose intolerance in Saudi postpartum women: Sub-group analysis from RAHMA study.

PLoS One 2019 7;14(1):e0210024. Epub 2019 Jan 7.

Department of Family and Community Medicine, College of Medicine, King Saud University, Riyadh, Saudi Arabia.

Objectives: The objectives of this study were to determine incidence and risk factors of glucose intolerance one year after delivery in a sub-cohort of Riyadh Mother and Baby Cohort Study (RAHMA) study.

Methods: This is a follow-up study of a sub-cohort from RAHMA study from King Khalid University Hospital (KKUH). All women from RAHMA database who completed one year since delivery at KKUH were contacted by phone to participate in the study. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0210024PLOS
January 2019
4 Reads

Relationship of lactation, BMI, and rs12255372 TCF7L2 polymorphism on the conversion to type 2 diabetes mellitus in women with previous gestational diabetes.

Gynecol Endocrinol 2019 Jan 7:1-5. Epub 2019 Jan 7.

a Department of Medical Sciences, Division of Health Sciences , University of Guanajuato , León , Mexico.

Women with previous gestational diabetes mellitus (pGDM) have a high risk of developing postpartum type 2 diabetes mellitus (T2DM). This study aimed to analyze the relationship between lactation, BMI, and TCF7L2 polymorphisms in the conversion to T2DM in women with pGDM. One hundred and fifty-three women con pGDM were recruited from public hospitals of León Guanajuato México. Read More

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https://www.tandfonline.com/doi/full/10.1080/09513590.2018.1
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http://dx.doi.org/10.1080/09513590.2018.1531984DOI Listing
January 2019
1 Read

Effect of metal ions present in milk on the structure and functional integrity of native and polyaniline chitosan nanocomposites bound β-galactosidase: A multi-spectroscopic approach.

Food Chem 2019 May 11;279:312-320. Epub 2018 Dec 11.

Department of Biochemistry, Faculty of Life Sciences, Aligarh Muslim University, Aligarh 202002, U.P., India. Electronic address:

β-Galactosidase is vital to dairy industries because it catalyzes the hydrolysis of lactose into glucose and galactose making it useful for lactose intolerant patients to consume milk and its products. The present study demonstrates the effect of metal ions commonly found in milk, namely Zn, K, Ca and Mn on the activity of native and polyaniline chitosan nanocomposites bound Aspergillus oryzae β-galactosidase. In polyaniline chitosan silver nanocomposite adsorbed β-galactosidase, a multi-fold enhancement in catalytic activity was observed in the presence of cocktail of Zn, K, Ca and Mn ions. Read More

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http://dx.doi.org/10.1016/j.foodchem.2018.12.022DOI Listing

Metabolic disturbances in non-obese women with polycystic ovary syndrome: a systematic review and meta-analysis.

Fertil Steril 2019 Jan;111(1):168-177

Center for Reproductive Medicine, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, People's Republic of China; National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Jinan, People's Republic of China; The Key Laboratory of Reproductive Endocrinology (Shandong University), Ministry of Education, Jinan, People's Republic of China; Center for Reproductive Medicine, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Jinan, People's Republic of China; Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics, Shanghai, People's Republic of China.

Objective: To explore metabolic disturbances in nonobese women with polycystic ovary syndrome (PCOS) compared with nonobese healthy controls.

Design: Systematic review and meta-analysis.

Setting: Not applicable. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00150282183207
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http://dx.doi.org/10.1016/j.fertnstert.2018.09.013DOI Listing
January 2019
4 Reads

High-fat diet accelerates extreme obesity with hyperphagia in female heterozygous Mecp2-null mice.

PLoS One 2019 4;14(1):e0210184. Epub 2019 Jan 4.

Department of Pediatrics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto City, Japan.

Rett syndrome (RTT) is an X-linked neurodevelopmental disorder caused by mutation of the methyl-CpG-binding protein 2 (MECP2) gene. Although RTT has been associated with obesity, the underlying mechanism has not yet been elucidated. In this study, female heterozygous Mecp2-null mice (Mecp2+/- mice), a model of RTT, were fed a normal chow diet or high-fat diet (HFD), and the changes in molecular signaling pathways were investigated. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0210184PLOS
January 2019

Circulating concentrations of insulin resistance-associated hepatokines, selenoprotein P and leukocyte cell-derived chemotaxin 2, during an oral glucose tolerance test in humans.

Biol Pharm Bull 2018 Dec 28. Epub 2018 Dec 28.

Department of Endocrinology and Metabolism, Kanazawa University Graduate School of Medical Sciences.

A hepatokine is a collective term for liver-derived secretory factors whose previously-unrecognized functions have been recently elucidated. We have rediscovered selenoprotein P (SeP) and leukocyte cell-derived chemotaxin 2 (LECT2) as hepatokines that are involved in the development of insulin resistance and hyperglycemia. The aim of this study was to determine whether and, if so, how oral glucose loading alters the two hepatokines in humans. Read More

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http://dx.doi.org/10.1248/bpb.b18-00549DOI Listing
December 2018

The role of metabolic disorders in the pathogenesis of intrahepatic cholestasis of pregnancy.

Clin Exp Hepatol 2018 Dec 3;4(4):217-223. Epub 2018 Dec 3.

Department of Gastroenterology and Hepatology, School of Medicine in Katowice, Medical University of Silesia in Katowice, Poland.

Intrahepatic cholestasis of pregnancy (ICP) is a pregnancy-specific liver disorder which typically commences in the late second or third trimester and resolves within 48 hours after delivery. It is characterized by mild to severe pruritus, without any specific dermatologic features, elevated liver enzymes and increased serum bile acids (BA). The etiology of ICP is still not completely explicit. Read More

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http://dx.doi.org/10.5114/ceh.2018.80122DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311745PMC
December 2018

Diabetes mellitus and thyroid diseases.

Authors:
Masahiro Nishi

Diabetol Int 2018 May 9;9(2):108-112. Epub 2018 Mar 9.

Division of Clinical Nutrition and Metabolism, Wakayama Medical University, 811-1 Kimiidera, Wakayama, Wakayama 641-8509 Japan.

Both diabetes mellitus and thyroid diseases are very common in the fields of endocrinology and metabolism. Coexistence of diabetes mellitus and thyroid diseases are frequently experienced. However, higher prevalence of thyroid dysfunction in both type 1 and type 2 diabetes compared with non-diabetics have been reported. Read More

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http://dx.doi.org/10.1007/s13340-018-0352-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6224947PMC

Phospholamban Deficiency Does Not Alter Skeletal Muscle SERCA Pumping Efficiency or Predispose Mice to Diet-Induced Obesity.

Am J Physiol Endocrinol Metab 2019 Jan 2. Epub 2019 Jan 2.

Department of Kinesiology, University of Waterloo, Canada.

The sarco(endo)plasmic reticulum Ca-ATPase (SERCA) pump is a major contributor to skeletal muscle Ca homeostasis and metabolic rate. SERCA activity can become adaptively uncoupled by its regulator sarcolipin (SLN) to increase the energy demand of Ca pumping, preventing excessive obesity and glucose intolerance in mice. Several other SERCA regulators bear structural and functional resemblance to SLN, including phospholamban (PLN). Read More

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http://dx.doi.org/10.1152/ajpendo.00288.2018DOI Listing
January 2019

Sex-dependent effects of bisphenol A on type 1 diabetes development in non-obese diabetic (NOD) mice.

Arch Toxicol 2019 Jan 2. Epub 2019 Jan 2.

Department of Veterinary Biosciences and Diagnostic Imaging, College of Veterinary Medicine, University of Georgia, Athens, GA, 30602, USA.

Type 1 diabetes (T1D) is an autoimmune disease caused by immune-mediated pancreatic β-cell destruction. The endocrine disrupting chemical bisphenol A (BPA) has widespread human exposure and can modulate immune function and the gut microbiome (GMB), which may contribute to the increasing T1D incidence worldwide. It was hypothesized that BPA had sex-dependent effects on T1D by modulating immune homeostasis and GMB. Read More

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http://dx.doi.org/10.1007/s00204-018-2379-5DOI Listing
January 2019

Chicken Protein Hydrolysates Have Anti-Inflammatory Effects on High-Fat Diet Induced Obesity in Mice.

Medicines (Basel) 2018 Dec 28;6(1). Epub 2018 Dec 28.

Department of Clinical Science, University of Bergen, N-5020 Bergen, Norway.

: Studies have shown that dietary source of protein and peptides can affect energy metabolism and influence obesity-associated diseases. This study aimed to investigate the impact of different chicken protein hydrolysates (CPHs) generated from chicken rest raw materials in a mouse obesity model. : Male C57BL/6 mice were fed a high-fat, high-sucrose diet with casein or CPHs generated using Papain + Bromelain, Alcalase, Corolase PP, or Protamex for 12 weeks ( = 12). Read More

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http://dx.doi.org/10.3390/medicines6010005DOI Listing
December 2018

Obesity: Pathophysiology, monosodium glutamate-induced model and anti-obesity medicinal plants.

Biomed Pharmacother 2018 Dec 28;111:503-516. Epub 2018 Dec 28.

Laboratory of Bioenergetics and Cellular Aging, Department of Health Sciences, Division of Health and Biological Sciences, Metropolitan Autonomous University, Mexico.

Obesity and overweight have increased at an alarming rate in the world during the last three decades. Obesity is a crucial factor in the development of metabolic abnormalities, including glucose intolerance, insulin resistance, metabolic syndrome, low-grade inflammation and oxidative stress. A similar scinario occurs during the aging process where alterations of the energetic metabolism homeostasis and a chronic systematic low-grade inflammation have been observed. Read More

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http://dx.doi.org/10.1016/j.biopha.2018.12.108DOI Listing
December 2018

Estradiol protects against ovariectomy-induced susceptibility to the anabolic effects of glucocorticoids in rats.

Life Sci 2018 Dec 27. Epub 2018 Dec 27.

Department of Physiological Sciences, State University of Londrina, Londrina, PR, Brazil. Electronic address:

Glucocorticoids increase appetite and body weight gain in rats and ovariectomy (OVX) induces obesity, while estrogen (E) replacement attenuates OVX-induced changes. It is known that animals with obesity are more responsive to glucocorticoids anabolic effects than lean ones. This study aimed to evaluate the effects of ovariectomy and the protective role of estradiol on the responses induced by prolonged treatment with corticosterone or dexamethasone on energy homeostasis. Read More

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http://dx.doi.org/10.1016/j.lfs.2018.12.037DOI Listing
December 2018
1 Read

A single extra copy of Down syndrome critical region 1-4 results in impaired hepatic glucose homeostasis.

Mol Metab 2018 Dec 5. Epub 2018 Dec 5.

Department of Molecular Cell Biology, Samsung Biomedical Research Institute, Sungkyunkwan University School of Medicine, Suwon, Gyeonggi-do, 16419, South Korea; Department of Health Sciences and Technology, Samsung Advanced Institute for Health Sciences and Technology, Samsung Medical Center, Sungkyunkwan University, Seoul, 06351, South Korea. Electronic address:

Objectives: During fasting, hepatic gluconeogenesis is induced to maintain energy homeostasis. Moreover, abnormal dysregulation of hepatic glucose production is commonly observed in type 2 diabetes. However, the signaling components controlling hepatic glucose production to maintain normal glucose levels are not fully understood. Read More

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http://dx.doi.org/10.1016/j.molmet.2018.12.002DOI Listing
December 2018

Polysaccharide-Enriched Fraction from Fruiting Body Improves Insulin Resistance.

Molecules 2018 Dec 22;24(1). Epub 2018 Dec 22.

School of Life Sciences, Northeast Normal University, 130024 Jilin, China.

Despite the edible fungus possessing a variety of biological activities, its effects on diabetes are still unclear. Polysaccharides are the main bioactive ingredients. In order to destroy the cell wall to obtain more polysaccharides, we used NaOH solution to extract fruiting bodies. Read More

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http://www.mdpi.com/1420-3049/24/1/46
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http://dx.doi.org/10.3390/molecules24010046DOI Listing
December 2018
2 Reads

Inhibition of Maillard reactions by replacing galactose with galacto-oligosaccharides in casein model systems.

J Agric Food Chem 2018 Dec 24. Epub 2018 Dec 24.

Lactose reduced dairy products are more prone to Maillard reactions due to the presence of reactive monosaccharides. Conventional β-galactosidases, which are used for lactose hydrolysis in lactose reduced dairy products, will lead to conversion of lactose into glucose and galactose, where especially galactose is very reactive during Maillard reactions. Some β-galactosidases have transgalactosylating activity, and will thus convert lactose into galacto-oligosaccharides (GOS) and hereby limit the release of galactose. Read More

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http://dx.doi.org/10.1021/acs.jafc.8b05565DOI Listing
December 2018
2.912 Impact Factor

Inhibition of Mevalonate Pathway Prevents Adipocyte Browning in Mice and Men by Affecting Protein Prenylation.

Cell Metab 2018 Dec 14. Epub 2018 Dec 14.

Institute of Food, Nutrition, and Health, ETH Zürich, Schorenstrasse 16, Schwerzenbach 8603, Switzerland. Electronic address:

Recent research focusing on brown adipose tissue (BAT) function emphasizes its importance in systemic metabolic homeostasis. We show here that genetic and pharmacological inhibition of the mevalonate pathway leads to reduced human and mouse brown adipocyte function in vitro and impaired adipose tissue browning in vivo. A retrospective analysis of a large patient cohort suggests an inverse correlation between statin use and active BAT in humans, while we show in a prospective clinical trial that fluvastatin reduces thermogenic gene expression in human BAT. Read More

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http://dx.doi.org/10.1016/j.cmet.2018.11.017DOI Listing
December 2018
1 Read

Secreted modular calcium-binding protein 2 promotes high fat diet (HFD)-induced hepatic steatosis through enhancing lipid deposition, fibrosis and inflammation via targeting TGF-β1.

Biochem Biophys Res Commun 2019 Jan 20;509(1):48-55. Epub 2018 Dec 20.

Department of General Surgery II Ward, Second Hospital of Yulin City, Yulin, 719000, China. Electronic address:

The molecular mechanism revealing the pathogenesis of non-alcoholic fatty liver disease (NAFLD), one of the most common liver diseases, remains to be investigated. In the study, we found that secreted modular calcium-binding protein 2 (SMOC2), which belongs to the secreted protein acidic and rich in cysteine (SPARC) family of matricellular proteins, functioned as a positive modulator of NAFLD. SMOC2 expression was markedly up-regulated in human liver samples with NAFLD, and in hepatic tissues of mice fed with HFD. Read More

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http://dx.doi.org/10.1016/j.bbrc.2018.12.006DOI Listing
January 2019
1 Read

Potential role of E4orf1 protein in aging-associated impairment in glycemic control.

J Diabetes Complications 2018 Nov 22. Epub 2018 Nov 22.

Obesity and Metabolic Health Laboratory, Nutritional Sciences Department, Texas Tech University, Lubbock, TX 79409, USA. Electronic address:

Aging constitutes a major risk factor for the development of type-2 diabetes (T2D) where glucose tolerance declines with age, resulting in a high prevalence of T2D and impaired glucose tolerance in the elderly population. Currently more than half of the 20 million U.S. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10568727183102
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http://dx.doi.org/10.1016/j.jdiacomp.2018.11.006DOI Listing
November 2018
3 Reads

Salivary Adiponectin and Leptin Levels are Increased in Women with Gestational Diabetes Mellitus and Gingival Inflammation.

Oral Health Prev Dent 2018 ;16(6):541-547

Purpose: Gestational diabetes mellitus (GDM) is defined as glucose intolerance with first onset or diagnosis in pregnancy. This study evaluated clinical and biochemical parameters in a possible association between GDM and gingival inflammation.

Materials And Methods: A total of 87 pregnant women - 44 with GDM and 43 without (NGDM) - were included. Read More

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http://dx.doi.org/10.3290/j.ohpd.a41658DOI Listing
January 2018

Sexual dimorphism in developmental and diet-dependent circulating retinol binding protein 4.

Obes Sci Pract 2018 Dec 22;4(6):526-534. Epub 2018 Oct 22.

Departments of Biochemistry, Case Comprehensive Cancer Center Case Western Reserve University School of Medicine Cleveland OH USA.

Objective: Retinol binding protein 4 (RBP4) transports vitamin A (Retinol) in the blood and contributes mechanistically to the linkage between obesity, insulin resistance and associated comorbidities including type 2 diabetes mellitus, coronary artery and neoplastic diseases. Circulating RBP4 levels have variably been associated with body mass and gender differences. Many of these differences have been demonstrated after limited dietary interventions, and/or at single unique time points. Read More

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http://doi.wiley.com/10.1002/osp4.301
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http://dx.doi.org/10.1002/osp4.301DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6298211PMC
December 2018
3 Reads

Sonic hedgehog signaling instigates high-fat diet-induced insulin resistance by targeting PPARγ stability.

J Biol Chem 2018 Dec 20. Epub 2018 Dec 20.

Dalian Medical University, China.

Obesity is a major risk for patients with chronic metabolic disorders including type 2 diabetes. Sonic hedgehog (Shh) is a morphogen that regulates the pancreas and adipose tissue formation during embryonic development. Peroxisome proliferator-activated receptor γ (PPARγ) is a member of the nuclear receptor superfamily and one of the most important regulators of insulin action. Read More

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http://dx.doi.org/10.1074/jbc.RA118.004411DOI Listing
December 2018

[Evaluation of peer support education mode for type 2 diabetes control in rural residents].

Zhonghua Liu Xing Bing Xue Za Zhi 2018 Dec;39(12):1560-1564

Changping Nankou Community Health Service Center, Beijing 102200, China.

To evaluate the intervention effects of peer support education mode for type 2 diabetes control in rural residents. A random cluster sampling method has been used, including 300 rural residents aged above 18 years old from three villages (184 in control group, 116 in intervention group), in order to proceed the physical check-up and health education programs. Unchanged rate, transfer rate of patients, rate of impaired glucose tolerance, turn normal rate and other biochemical indicators of patients and people with impaired glucose tolerance from control group and intervention group were analyzed, to evaluate the intervention effects of peer support education mode. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0254-6450.2018.12.005DOI Listing
December 2018

Deletion distal to the PAX6 coding region reveals a novel basis for familial cosegregation of aniridia and diabetes mellitus.

Diabetes Res Clin Pract 2018 Dec 17;148:64-71. Epub 2018 Dec 17.

Diabetes Centre, St Vincent's Hospital, Sydney, New South Wales, Australia; Diabetes and Metabolism Division, Garvan Institute of Medical Research, Darlinghurst, Australia; St Vincent's Clinical School, UNSW Sydney, Australia; Department of Endocrinology, St Vincent's Hospital, Sydney, Australia.

Aims: Analyze cosegregation of aniridia and diabetes to identify genetic criteria for detection and early treatment of diabetes-susceptible aniridia patients.

Methods: We assessed a two-generation family: three individuals with aniridia, two previously diagnosed as type 2 diabetes. One individual with aniridia, with unknown diabetes status, was evaluated by oral glucose tolerance test. Read More

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http://dx.doi.org/10.1016/j.diabres.2018.12.002DOI Listing
December 2018

Cognitive, behavioral and metabolic effects of oral galactose treatment in the transgenic Tg2576 mice.

Neuropharmacology 2018 Dec 17;148:50-67. Epub 2018 Dec 17.

Department of Pharmacology, University of Zagreb School of Medicine, Salata 11, HR-10 000, Zagreb, Croatia; Research Centre of Excellence of Fundamental, Clinical and Translational Neuroscience, Croatian Institute for Brain Research, University of Zagreb School of Medicine, Salata 12, HR-10 000, Zagreb, Croatia. Electronic address:

Alzheimer's disease (AD) is the most common neurodegenerative disorder associated with insulin resistance and glucose hypometabolism in the brain. Oral administration of galactose, a nutrient that provides an alternative source of energy, prevents and ameliorates early cognitive impairment in a streptozotocin-induced model (STZ-icv) of the sporadic AD (sAD). Here we explored the influence of 2-month oral galactose treatment (200 mg/kg/day) in the familial AD (fAD) by using 5- (5M) and 10- (10M) month-old transgenic Tg2576 mice mimicking the presymptomatic and the mild stage of fAD, and compared it to that observed in 7-month old STZ-icv rats mimicking mild-to-moderate sAD. Read More

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http://dx.doi.org/10.1016/j.neuropharm.2018.12.018DOI Listing
December 2018

Cervical vagal nerve stimulation impairs glucose tolerance and suppresses insulin release in conscious rats.

Physiol Rep 2018 Dec;6(24):e13953

Department of Health and Human Physiology, The University of Iowa, Iowa City, Iowa, USA.

Previously, we reported that cervical vagal nerve stimulation (VNS) increases blood glucose levels and inhibits insulin secretion in anesthetized rats through afferent signaling. Since afferent signaling is also thought to mediate the therapeutic effects of VNS in patients with therapy-refractory epilepsy and major depression, the question arises if patients treated with VNS develop impaired glucose tolerance. Thus, we hypothesized that cervical VNS impairs glucose tolerance in conscious rats. Read More

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http://dx.doi.org/10.14814/phy2.13953DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6300710PMC
December 2018

Testosterone, sex hormone-binding globulin and risk of cardiovascular events: A report from the Outcome Reduction with an Initial Glargine Intervention trial.

Eur J Prev Cardiol 2018 Dec 19:2047487318819142. Epub 2018 Dec 19.

1 Department of Medicine Solna, Karolinska Institutet, Sweden.

Aims: Testosterone and its binding protein sex hormone-binding globulin have been associated with cardiovascular disease and dysglycaemia. However, information on the prognostic implication in patients at high cardiovascular risk with dysglycaemia is inconsistent. The study objective was to determine whether testosterone and/or sex hormone-binding globulin predict cardiovascular events or death in dysglycaemic patients. Read More

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http://dx.doi.org/10.1177/2047487318819142DOI Listing
December 2018

Arsenic modifies serotonin metabolism through glucuronidation in pancreatic β-cells.

Am J Physiol Endocrinol Metab 2018 Dec 18. Epub 2018 Dec 18.

Division of Molecular and Metabolic Medicine, Kobe University Graduate School of Medicine, Japan.

In arsenic-endemic regions of the world, arsenic exposure correlates with diabetes mellitus. Multiple animal models of inorganic arsenic (iAs, As) exposure have revealed that iAs-induced glucose intolerance manifests as a result of pancreatic β-cell dysfunction. To define the mechanisms responsible for this β-cell defect, the MIN6-K8 mouse β-cell line was exposed to environmentally-relevant doses of iAs. Read More

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http://dx.doi.org/10.1152/ajpendo.00302.2018DOI Listing
December 2018

Late onset obesity in mice with targeted deletion of potassium inward rectifier Kir7.1 from cells expressing the melanocortin-4 receptor.

J Neuroendocrinol 2018 Dec 17:e12670. Epub 2018 Dec 17.

Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee.

Energy stores in fat tissue are determined in part by the activity of hypothalamic neurons expressing the melanocortin-4 receptor (MC4R). Even partial reduction in MC4R expression levels in mice, rats, or humans produces hyperphagia and morbid obesity. Thus, it is of great interest to understand the molecular basis of neuromodulation by the MC4R. Read More

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http://doi.wiley.com/10.1111/jne.12670
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http://dx.doi.org/10.1111/jne.12670DOI Listing
December 2018
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Beneficial effects of maternal swimming during pregnancy on offspring metabolism when the father is obese.

J Dev Orig Health Dis 2018 Dec 18:1-5. Epub 2018 Dec 18.

Laboratory of Morphometry, Metabolism, and Cardiovascular Diseases,Biomedical Center,Institute of Biology,The University of the State of Rio de Janeiro,Brazil.

We aimed to evaluate the impact of maternal exercise training on the offspring metabolism and body size caused by father obesity. C57BL/6 male 4-week-old mice were fed a high-fat diet (HF father) or control diet (C father), while equal age female mice were fed only a C diet and were separated into two groups: trained (T mother) and non-trained (NT mother), and at 12 weeks of age mice were mated. A continuous swimming protocol was applied for 10 weeks (before and during gestation), and offspring were followed since weaning until sacrifice (at 12 weeks of age). Read More

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http://dx.doi.org/10.1017/S2040174418001046DOI Listing
December 2018

Barriers to Postpartum Glucose Intolerance Screening in an Italian Population.

Int J Environ Res Public Health 2018 12 14;15(12). Epub 2018 Dec 14.

Unit of Obstetrics and Gynecology, Department of Medical and Surgical Sciences, University "Magna Græcia'' of Catanzaro, Viale Europa, 88100 Catanzaro, Italy.

: Gestational diabetes mellitus (GDM) is a strong risk factor for type 2 diabetes mellitus (T2D) and the postpartum period is crucial for early treatment in at-risk women. However, despite recommendations, only a fraction of women undergo a postpartum screening for glucose intolerance (ppOGTT). The present study aims to verify the reason(s) for poor adherence in our population. Read More

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http://www.mdpi.com/1660-4601/15/12/2853
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http://dx.doi.org/10.3390/ijerph15122853DOI Listing
December 2018
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Assessing the in vivo data on low/no-calorie sweeteners and the gut microbiota.

Food Chem Toxicol 2018 Dec 14;124:385-399. Epub 2018 Dec 14.

University of Reading, Department of Food and Nutritional Sciences, PO Box 226, Whiteknights, Reading, RG6 6AP, UK.

Low/no-calorie sweeteners (LNCS) are continually under the spotlight in terms of their safety and benefits; in 2014 a study was published linking LNCS to an enhanced risk of glucose intolerance through modulation of the gut microbiota. In response, an in-depth review of the literature was undertaken to evaluate the major contributors to potential changes in the gut microbiota and their corresponding sequelae, and to determine if consuming LNCS (e.g. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S02786915183087
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http://dx.doi.org/10.1016/j.fct.2018.12.005DOI Listing
December 2018
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Drosophila HNF4 Directs a Switch in Lipid Metabolism that Supports the Transition to Adulthood.

Dev Cell 2018 Dec 10. Epub 2018 Dec 10.

Department of Human Genetics, University of Utah School of Medicine, Salt Lake City, UT 84112-5330, USA. Electronic address:

Animals must adjust their metabolism as they progress through development in order to meet the needs of each stage in the life cycle. Here, we show that the dHNF4 nuclear receptor acts at the onset of Drosophila adulthood to direct an essential switch in lipid metabolism. Lipid stores are consumed shortly after metamorphosis but contribute little to energy metabolism. Read More

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http://dx.doi.org/10.1016/j.devcel.2018.11.030DOI Listing
December 2018

Female adipose tissue-specific Bscl2 knockout mice develop only moderate metabolic dysfunction when housed at thermoneutrality and fed a high-fat diet.

Sci Rep 2018 Dec 14;8(1):17863. Epub 2018 Dec 14.

The Rowett Institute, University of Aberdeen, Aberdeen, UK.

Mutations affecting the BSCL2 gene cause the most severe form of congenital generalised lipodystrophy. Affected individuals almost completely lack adipose tissue and suffer from severe diabetes and metabolic complications. Likewise, mice lacking Bscl2 in all tissues have dramatically reduced adipose mass, glucose intolerance and hyperinsulinaemia. Read More

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http://dx.doi.org/10.1038/s41598-018-36078-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6294754PMC
December 2018

Age-Dependent Protection of Insulin Secretion in Diet Induced Obese Mice.

Sci Rep 2018 Dec 13;8(1):17814. Epub 2018 Dec 13.

Department of Medicine, Division of Endocrinology, Diabetes, and Metabolism, University of Wisconsin-Madison, and the William S. Middleton Memorial Veterans Hospital, Madison, WI, USA.

Type 2 diabetes is an age-and-obesity associated disease driven by impairments in glucose homeostasis that ultimately result in defective insulin secretion from pancreatic β-cells. To deconvolve the effects of age and obesity in an experimental model of prediabetes, we fed young and aged mice either chow or a short-term high-fat/high-sucrose Western diet (WD) and examined how weight, glucose tolerance, and β-cell function were affected. Although WD induced a similar degree of weight gain in young and aged mice, a high degree of heterogeneity was found exclusively in aged mice. Read More

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http://dx.doi.org/10.1038/s41598-018-36289-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6292902PMC
December 2018

A Multi-Mode Bioactive Agent Isolated From L. Fill. With Therapeutic Potential for Type 2 Diabetes Mellitus.

Front Pharmacol 2018 27;9:1376. Epub 2018 Nov 27.

Department of Biochemistry, Quaid-i-Azam University, Islamabad, Pakistan.

Type 2 diabetes is a metabolic disorder, characterized by hyperglycemia and glucose intolerance. Natural products and its derived active compounds may be achievable alternatives for the treatment of type 2 diabetes. In present study we investigated the antidiabetic potential of and isolated bioactive compounds i. Read More

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http://dx.doi.org/10.3389/fphar.2018.01376DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6277780PMC
November 2018

Differences in the actions of adrenaline and noradrenaline with regard to glucose intolerance in patients with pheochromocytoma.

Endocr J 2018 Dec 13. Epub 2018 Dec 13.

Department of Endocrinology and Diabetes Mellitus, Fukuoka University Chikushi Hospital, Chikushino, Fukuoka 818-8502, Japan.

Glucose intolerance is often observed in patients with pheochromocytoma. However, it remains controversial issue that glucose intolerance on pheochromocytoma is caused by impaired insulin secretion and/or by increased insulin resistance. We aimed to reveal the mechanism of glucose intolerance on pheochromocytoma with regard to the type and amount of catecholamines released. Read More

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http://dx.doi.org/10.1507/endocrj.EJ18-0407DOI Listing
December 2018

Macrophage LRP1 Promotes Diet-Induced Hepatic Inflammation and Metabolic Dysfunction by Modulating Wnt Signaling.

Mediators Inflamm 2018 4;2018:7902841. Epub 2018 Nov 4.

Center for Vascular and Inflammatory Diseases, University of Maryland School of Medicine, Baltimore, MD 21201, USA.

Hepatic inflammation is associated with the development of insulin resistance, which can perpetuate the disease state and may increase the risk of metabolic syndrome and diabetes. Despite recent advances, mechanisms linking hepatic inflammation and insulin resistance are still unclear. The low-density lipoprotein receptor-related protein 1 (LRP1) is a large endocytic and signaling receptor that is highly expressed in macrophages, adipocytes, hepatocytes, and vascular smooth muscle cells. Read More

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http://dx.doi.org/10.1155/2018/7902841DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6247401PMC
November 2018

GPR120 protects lipotoxicity-induced pancreatic β-cell dysfunction through regulation of PDX1 expression and inhibition of islet inflammation.

Clin Sci (Lond) 2019 Jan 11;133(1):101-116. Epub 2019 Jan 11.

School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong, China

G-protein coupled receptor 120 (GPR120) has been shown to act as an omega-3 unsaturated fatty acid sensor and is involved in insulin secretion. However, the underlying mechanism in pancreatic β cells remains unclear. To explore the potential link between GPR120 and β-cell function, its agonists docosahexaenoic acid (DHA) and GSK137647A were used in palmitic acid (PA)-induced pancreatic β-cell dysfunction, coupled with GPR120 knockdown (KD) in MIN6 cells and GPR120 knockout (KO) mice to identify the underlying signaling pathways. Read More

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http://clinsci.org/lookup/doi/10.1042/CS20180836
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http://dx.doi.org/10.1042/CS20180836DOI Listing
January 2019
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