17,692 results match your criteria Glucose Intolerance


The Gut Microbiota in Prediabetes and Diabetes: A Population-Based Cross-Sectional Study.

Cell Metab 2020 Jul 2. Epub 2020 Jul 2.

The Wallenberg Laboratory, Department of Molecular and Clinical Medicine, Sahlgrenska Academy, University of Gothenburg, Bruna Stråket 16, 41345 Gothenburg, Sweden; Region Västra Götaland, Sahlgrenska University Hospital, Department of Clinical Physiology, Gothenburg, Sweden; Novo Nordisk Foundation Center for Basic Metabolic Research, Section for Metabolic Receptology and Enteroendocrinology, Faculty of Health Science University of Copenhagen, Copenhagen, Denmark. Electronic address:

The link between the gut microbiota and type 2 diabetes (T2D) warrants further investigation because of known confounding effects from antidiabetic treatment. Here, we profiled the gut microbiota in a discovery (n = 1,011) and validation (n = 484) cohort comprising Swedish subjects naive for diabetes treatment and grouped by glycemic status. We observed that overall gut microbiota composition was altered in groups with impaired glucose tolerance, combined glucose intolerance and T2D, but not in those with impaired fasting glucose. Read More

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http://dx.doi.org/10.1016/j.cmet.2020.06.011DOI Listing

Intestinal epithelial chemokine (C-C motif) ligand 7 overexpression protects against high fat diet-induced obesity and hepatic steatosis in mice.

Chin Med J (Engl) 2020 Jul 7. Epub 2020 Jul 7.

Department of Pathophysiology, Guangdong Provincial Key Laboratory of Proteomics, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong 510515 China.

Background: We previously found that the intestinal epithelial chemokine (C-C motif) ligand 7 (CCL7) plays an important role in the development of toxin-induced acute liver damage. The detailed effects of intestinal epithelial CCL7 on chronic diseases; however, are still unclear. Here, we aimed to investigate the impact of intestinal epithelial CCL7 overexpression on high-fat diet (HFD)-induced obesity and steatohepatitis in mice. Read More

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http://dx.doi.org/10.1097/CM9.0000000000000915DOI Listing

The effect of 8 plant extracts and combinations on post-prandial blood glucose and insulin responses in healthy adults: a randomized controlled trial.

Nutr Metab (Lond) 2020 6;17:51. Epub 2020 Jul 6.

Unilever R&D Shanghai, Shanghai, China.

Background: Lower post-prandial glucose (PPG) and insulin (PPI) responses to foods are associated with reduced diabetes risk and progression. Several plant extracts have been proposed to reduce PPG or PPI by inhibiting enzymes or transporters involved in carbohydrate digestion and uptake. This study evaluates a range of such extracts, consumed with a carbohydrate load, for their effects on PPG, PPI and indicators of (gastrointestinal) tolerance. Read More

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http://dx.doi.org/10.1186/s12986-020-00471-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7336677PMC

Botryosphaeran Attenuates Tumor Development and the Cancer Cachexia Syndrome in Walker-256 Tumor-Bearing Obese Rats and Improves the Metabolic and Hematological Profiles of These Rats.

Nutr Cancer 2020 Jul 8:1-18. Epub 2020 Jul 8.

Núcleo de Pesquisa e Apoio Didático em Saúde (NUPADS), Instituto de Ciências da Saúde, Câmpus Universitário de Sinop, Universidade Federal de Mato Grosso, Sinop, MT, Brazil.

Studies demonstrate that obesity can increase tumor development. Botryosphaeran, a fungal (1→3)(1→6)-β-D-glucan, presents antimutagenic, antiproliferative and pro-apoptotic activities. This study evaluated the effects of botryosphaeran on tumor development and metabolic and hematological parameters in tumor-bearing obese and non-obese rats. Read More

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http://dx.doi.org/10.1080/01635581.2020.1789681DOI Listing

Protein acetylation derepresses Serotonin Synthesis to potentiate Pancreatic Beta-Cell Function through HDAC1-PKA-Tph1 signaling.

Theranostics 2020 5;10(16):7351-7368. Epub 2020 Jun 5.

Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Department of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 200025, China.

Protein acetylation is tightly linked to transcriptional control and energy metabolism. However, the role of protein acetylation in islet function remains enigmatic. This study aims to determine how protein acetylation controls β-cell function and explore the underlying mechanism. Read More

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http://dx.doi.org/10.7150/thno.44459DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7330849PMC

Lipocalin-2 counteracts metabolic dysregulation in obesity and diabetes.

J Exp Med 2020 Oct;217(10)

Department of Physiology and Cellular Biophysics, Columbia University Medical Center, New York, NY.

Regulation of food intake is a recently identified endocrine function of bone that is mediated by Lipocalin-2 (LCN2). Osteoblast-secreted LCN2 suppresses appetite and decreases fat mass while improving glucose metabolism. We now show that serum LCN2 levels correlate with insulin levels and β-cell function, indices of healthy glucose metabolism, in obese mice and obese, prediabetic women. Read More

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http://dx.doi.org/10.1084/jem.20191261DOI Listing
October 2020

Adult mouse hippocampal transcriptome changes associated with long-term behavioral and metabolic effects of gestational air pollution toxicity.

Transl Psychiatry 2020 Jul 7;10(1):218. Epub 2020 Jul 7.

Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA.

Gestational exposure to air pollution increases the risk of autism spectrum disorder and cognitive impairments with unresolved molecular mechanisms. This study exposed C57BL/6J mice throughout gestation to urban-derived nanosized particulate matter (nPM). Young adult male and female offspring were studied for behavioral and metabolic changes using forced swim test, fat gain, glucose tolerance, and hippocampal transcriptome. Read More

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http://dx.doi.org/10.1038/s41398-020-00907-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7341755PMC

Dietary Recommendations for Familial Hypercholesterolaemia: an Evidence-Free Zone.

BMJ Evid Based Med 2020 Jul 5. Epub 2020 Jul 5.

Department of Human Sciences, The Ohio State University, Columbus, Ohio, USA.

We have evaluated dietary recommendations for people diagnosed with familial hypercholesterolaemia (FH), a genetic condition in which increased low-density lipoprotein cholesterol (LDL-C) is associated with an increased risk for coronary heart disease (CHD). Recommendations for FH individuals have emphasised a low saturated fat, low cholesterol diet to reduce their LDL-C levels. The basis of this recommendation is the 'diet-heart hypothesis', which postulates that consumption of food rich in saturated fat increases serum cholesterol levels, which increases risk of CHD. Read More

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http://dx.doi.org/10.1136/bmjebm-2020-111412DOI Listing

Benefits of exercise in pregnancies with gestational diabetes.

J Matern Fetal Neonatal Med 2020 Jul 7:1-6. Epub 2020 Jul 7.

Reproductive Endocrinology Unit, 3rd Department of Obstetrics and Gynecology, University General Hospital "Attikon", Medical School, National and Kapodistrian University of Athens Greece, Athens, Greece.

A significant proportion of pregnancies are complicated by diabetes mellitus. Most of them concern women with gestational diabetes mellitus, while proportionally are presented with preexisting DM 1 and DM 2. Metabolic derangements of the diabetic syndrome are likely to generate serious complications for both the mother and the fetus with a significant impact on their later health. Read More

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http://dx.doi.org/10.1080/14767058.2020.1786515DOI Listing

Association between Neonatal birth weight and risk of maternal glucose intolerance after gestational diabetes mellitus.

J Diabetes Investig 2020 Jul 6. Epub 2020 Jul 6.

Department of Obstetrics and Gynaecology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.

Aims: To evaluate whether the neonatal birth weight(NBW) is associated with early postpartum glucose intolerance in women with gestational diabetes mellitus(GDM).

Methods: A total of 1113 women diagnosed with GDM who completed oral glucose tolerance test at 6-9 weeks postpartum between April 1 2014 and January 8 2020, were included in this observational prospective cohort study. They were grouped by neonatal birthweight quartiles and odds ratios of postpartum glucose intolerance for different levels of neonatal birth weight were assessed. Read More

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http://dx.doi.org/10.1111/jdi.13349DOI Listing

Maternal Exercise Improves High-Fat Diet-Induced Metabolic Abnormalities and Gut Microbiota Profiles in Mouse Dams and Offspring.

Front Cell Infect Microbiol 2020 17;10:292. Epub 2020 Jun 17.

Key Laboratory of Endocrinology, Department of Endocrinology, Ministry of Health, Translational Medicine Center, Peking Union Medical College, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China.

Early-life overnutrition programs increased risks of metabolic disorders in adulthood. Regular exercise has been widely accepted to be an effective measure to maintain metabolic health. However, the intergenerational effects of maternal exercise and the specific mechanism are largely unclear. Read More

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http://dx.doi.org/10.3389/fcimb.2020.00292DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7311581PMC

Liraglutide shows superior cardiometabolic benefits than lorcaserin in a novel free choice diet-induced obese rat model.

Eur J Pharmacol 2020 Jul 1:173316. Epub 2020 Jul 1.

Physiogenex, 280 rue de l'Hers, ZAC de la Masquère, 31750, Escalquens, France; Cardiomedex, 280 rue de l'Hers, ZAC de la Masquère, 31750, Escalquens, France.

Lorcaserin (LORCA) and liraglutide (LIRA) were evaluated in a novel diet-induced obese (DIO) rat model fed a free choice (FC) diet, that presents rats with the options between control chow (CC) or high fat/cholesterol (HFC) diet, and normal water (NW) or 10% fructose water (FW). After 8 weeks of FC diet-induced obesity/insulin resistance, rats were maintained on FC diet and treated daily for 5 weeks with vehicle, LORCA 18 mg/kg orally or LIRA 0.4 mg/kg subcutaneously. Read More

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http://dx.doi.org/10.1016/j.ejphar.2020.173316DOI Listing

Pancreatic ductal adenocarcinoma is associated with a unique endocrinopathy distinct from type 2 diabetes mellitus.

Pancreatology 2020 May 22. Epub 2020 May 22.

Department of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine and Science, Rochester, MN, USA; Department of Medicine, Division of Endocrinology, Metabolism, Diabetes, and Nutrition, Mayo Clinic College of Medicine and Science, Rochester, MN, USA. Electronic address:

Introduction: The majority of patients with pancreatic ductal adenocarcinoma (PC) display either impaired fasting glucose/glucose intolerance or overt diabetes. However, the pathophysiologic basis of this association remains largely unexplained.

Methods: In this case-control study we aimed to study the morphological changes in the islets of patients with PC, compared to control patients with and without type 2 diabetes mellitus (T2DM). Read More

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http://dx.doi.org/10.1016/j.pan.2020.05.010DOI Listing

Maternal obesity modulates both the renin-angiotensin system in mice dams and fetal adiposity.

J Nutr Biochem 2020 May 16;84:108413. Epub 2020 May 16.

Laboratory of Health Science, Montes Claros State University, Montes Claros, Minas Gerais, Brazil; Institute of Agricultural Sciences, Food Engineering College, Universidade Federal de Minas Gerais (UFMG), Minas Gerais, Brazil, Montes Claros, Minas Gerais, Brazil. Electronic address:

Obesity is a chronic multifactorial disease and is currently a public health problem. Maternal obesity during pregnancy is more dangerous as it impairs the health of the mother and future generations. Obesity leads to several metabolic disorders. Read More

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http://dx.doi.org/10.1016/j.jnutbio.2020.108413DOI Listing

Metabolic Syndrome is Associated with Ocular Hypertension and Glaucoma.

Authors:
Gavin W Roddy

J Glaucoma 2020 Jun 30. Epub 2020 Jun 30.

Department of Ophthalmology, Mayo Clinic, Rochester, Minnesota.

Glaucoma remains the world's leading cause of irreversible blindness and though intraocular pressure (IOP) is the most prevalent risk factor and only reliable therapeutic target, a number of systemic disease associations have been reported. Metabolic syndrome (MetS) is a constellation of findings that includes systemic hypertension, abdominal obesity, glucose intolerance, and dyslipidemia. MetS is becoming increasingly common world-wide, with prevalence up to 40% in some countries. Read More

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http://dx.doi.org/10.1097/IJG.0000000000001593DOI Listing

Comparison of Serum PCSK9 Levels in Subjects with Normoglycemia, Impaired Fasting Glucose, and Impaired Glucose Tolerance.

Endocrinol Metab (Seoul) 2020 Jun 24;35(2):480-483. Epub 2020 Jun 24.

Department of Internal Medicine, Keimyung University School of Medicine, Daegu, Korea.

We investigated proprotein convertase subtilisin/kexin type 9 (PCSK9) concentrations in individuals with normoglycemia, impaired fasting glucose (IFG), and impaired glucose tolerance (IGT). This was a pilot, cross-sectional study including 92 individuals who had not been diagnosed with or treated for diabetes. We measured PCSK9 levels in three groups of subjects; namely, normoglycemia (n=57), IFG (n=21), and IGT (n=14). Read More

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http://dx.doi.org/10.3803/EnM.2020.35.2.480DOI Listing

The Echo of Pulmonary Tuberculosis: Mechanisms of Clinical Symptoms and Other Disease-Induced Systemic Complications.

Clin Microbiol Rev 2020 Sep 1;33(4). Epub 2020 Jul 1.

Human Metabolomics, North-West University, Potchefstroom, North West, South Africa.

SUMMARYClinical symptoms of active tuberculosis (TB) can range from a simple cough to more severe reactions, such as irreversible lung damage and, eventually, death, depending on disease progression. In addition to its clinical presentation, TB has been associated with several other disease-induced systemic complications, such as hyponatremia and glucose intolerance. Here, we provide an overview of the known, although ill-described, underlying biochemical mechanisms responsible for the clinical and systemic presentations associated with this disease and discuss novel hypotheses recently generated by various omics technologies. Read More

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http://dx.doi.org/10.1128/CMR.00036-20DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7331478PMC
September 2020

Maternal high-fat diet regulates glucose metabolism and pancreatic β cell phenotype in mouse offspring at weaning.

PeerJ 2020 22;8:e9407. Epub 2020 Jun 22.

Department of Endocrinology, Peking University First Hospital, Beijing, China.

Background: Maternal malnutrition is a critical factor in determining the risk of obesity and glucose intolerance in offspring. However, little is known about the effects of a maternal high-fat diet (HFD) on the β cell phenotype in offspring, which is a major factor in glucose homeostasis, especially during the early life of offspring.

Methods: Dams were randomly fed a HFD (60% kcal from fat) or a chow diet before pregnancy and during gestation and lactation. Read More

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http://dx.doi.org/10.7717/peerj.9407DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7316079PMC

Metformin and risk of cancer among patients with type 2 diabetes mellitus: A systematic review and meta-analysis.

Prim Care Diabetes 2020 Jun 27. Epub 2020 Jun 27.

Department of Forensic Pathology, West China School of Basic Medical Sciences & Forensic Medicine, Sichuan University, Chengdu, Sichuan 610041, People's Republic of China. Electronic address:

Aim: We carried out this meta-analysis on all published studies to estimate the overall cancer risk of the use of metformin in T2DM patients.

Methods: We searched the PubMed, Embase and CNKI databases for all articles within a range of published years from 2007 to 2019 on the association between the use of metformin and cancer risk in T2DM patients. The odds ratio (OR) corresponding to the 95% confidence interval (95% CI) was used to assess the association using a random-effect meta-analysis. Read More

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http://dx.doi.org/10.1016/j.pcd.2020.06.001DOI Listing

Frequent and mild scrotal heat stress in mice epigenetically alters glucose metabolism in the male offspring.

Am J Physiol Endocrinol Metab 2020 Jun 30. Epub 2020 Jun 30.

Institute of Reproductive Health, Tongji Medical College, Huazhong University of Science and Technology, 13 Hangkong Road, Qiaokou District, Wuhan, 430030, P.R. China; Wuhan Tongji Reproductive Medicine Hospital, 128 Sanyang Road, Jiangan District, Wuhan, 430014, P.R. China.

Several studies have reported that health problems occur in assisted reproductive technology (ART)-conceived offspring. Recently, investigations have demonstrated that paternal environmental conditions influence offspring health. However, it is unclear whether the factors that cause male infertility per se affect offspring health and contribute to health problems in ART-born children. Read More

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http://dx.doi.org/10.1152/ajpendo.00038.2020DOI Listing

Deficiency of bone morphogenetic protein-3b induces metabolic syndrome and increases adipogenesis.

Am J Physiol Endocrinol Metab 2020 Jun 30. Epub 2020 Jun 30.

Cardiovascular Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, United States.

Bone Morphogenetic Protein (BMP) receptor signaling is critical for the regulation of the endocrine system and cardiovascular structure and function. The objective of this study was to investigate whether Bmp3b, a glycoprotein synthetized and secreted by adipose tissue, is necessary to regulate glucose and lipid metabolism, adipogenesis and cardiovascular remodeling. Over the course of 4 months, Bmp3b knock-out (Bmp3b) mice gained more weight than WT mice. Read More

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http://dx.doi.org/10.1152/ajpendo.00362.2019DOI Listing

Impact of human visceral and glutealfemoral adipose tissue transplant on glycemic control in a mouse model of diet-induced obesity.

Am J Physiol Endocrinol Metab 2020 Jun 30. Epub 2020 Jun 30.

Department of Physiology, Faculty of Medicine, Dentistry and Health Sciences, The University of Melbourne, Melbourne, Victoria, 3010, Australia.

Regional distribution of adipose tissue is an important factor in conferring cardiometabolic risk and obesity-related morbidity. We tested thehypothesis that human visceral adipose tissue (VAT) impairs glucose homeostasis, whereas subcutaneous glutealfemoral adipose tissue (GFAT)protects against the development of impaired glucose homeostasis in mice.VAT and GFAT were collected from patients undergoing bariatric surgery and grafted onto the epididymal adipose tissue of weight and age-matched severe combined immunodeficient mice. Read More

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http://dx.doi.org/10.1152/ajpendo.00373.2019DOI Listing

Cryptotanshinone ameliorates placental oxidative stress and inflammation in mice with gestational diabetes mellitus.

Arch Pharm Res 2020 Jun 29. Epub 2020 Jun 29.

Dermatological Department, Cangzhou People's Hospital, No. 7 Qingchi Avenue, Cangzhou, 061000, Hebei, China.

Gestational diabetes mellitus (GDM) is a conditional diabetes which is defined as any degree of glucose intolerance or high blood glucose levels during any phase of pregnancy. It causes chronic severe damage to health of the pregnant women and their offspring. In this study, we aimed to study the protective effects of Cryptotanshinone on GDM-related impairments. Read More

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http://dx.doi.org/10.1007/s12272-020-01242-1DOI Listing

Luteolin improves hypercholesterolemia and glucose intolerance through LXRα-dependent pathway in diet-induced obese mice.

J Food Biochem 2020 Jun 29:e13358. Epub 2020 Jun 29.

Research group of Healthcare, Korea Food Research Institute, Wanju-gun, Republic of Korea.

Luteolin, a naturally derived flavonoid, exerts beneficial effects such as antitumor, antioxidant, and anti-inflammatory effects. However, the molecular mechanism underlying the effect of luteolin in hypercholesterolemia remains unclear. In this study, we demonstrated that luteolin upregulated the expression of liver X receptor (LXR) α, ATP-binding cassette transporter G1 (ABCG1), and scavenger receptor class B member 1 (SRB1), which play a major role in cholesterol efflux, in HepG2 hepatocytes. Read More

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http://dx.doi.org/10.1111/jfbc.13358DOI Listing

The Unfolded Protein Response Regulates Hepatic Autophagy by sXBP1-mediated Activation of TFEB.

Autophagy 2020 Jun 28. Epub 2020 Jun 28.

Department of Anatomy and Cell Biology, Fraternal Order of Eagles Diabetes Research Center, Pappajohn Biomedical Institute, University of Iowa Carver College of Medicine , Iowa City, 52242.

Defective macroautophagy/autophagy and a failure to initiate the adaptive unfolded protein response (UPR) in response to the endoplasmic reticulum (ER) stress contributes to obesity-associated metabolic dysfunction. However, whether and how unresolved ER stress leads to defects in the autophagy pathway and to the progression of obesity-associated hepatic pathologies remains unclear. Obesity suppresses the expression of hepatic spliced XBP1 (X-box binding protein 1; sXBP1), the key transcription factor that promotes the adaptive UPR. Read More

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http://dx.doi.org/10.1080/15548627.2020.1788889DOI Listing

Bisphenol-A exposure worsens hepatic steatosis in ovariectomized mice fed on a high-fat diet: Role of endoplasmic reticulum stress and fibrogenic pathways.

Life Sci 2020 Jun 25:118012. Epub 2020 Jun 25.

Laboratório de Fisiopatologia, Divisão de Pesquisa Integrada em Produtos Bioativos e Biociências (DPBio), Polo Novo Cavaleiros, Universidade Federal do Rio de Janeiro, Campus UFRJ-Macaé, Macaé, RJ, Brazil; Setor de Ciências Biológicas e da Saúde (SEBISA), Departamento de Biologia Geral, Universidade Estadual de Ponta Grossa (UEPG), Ponta Grossa, PR, Brazil. Electronic address:

Aims: Bisphenol (BP)-A exposure can impair glucose and lipid metabolism. However, it is unclear whether this endocrine disruptor (ED) modulates these processes in postmenopause, a period with organic changes that increase the risk for metabolic diseases. Herein, we evaluated the effects of BPA exposure on adiposity, glucose homeostasis and hepatic steatosis in ovariectomized (OVX) mice fed on a high-fat diet (HFD). Read More

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http://dx.doi.org/10.1016/j.lfs.2020.118012DOI Listing

Activation of the renin-angiotensin system in high fructose-induced metabolic syndrome.

Korean J Physiol Pharmacol 2020 Jul;24(4):319-328

Department of Pharmacology, School of Medicine, Kyungpook National University, Daegu 41944, Korea.

High fructose intake induces hyperglycemia and hypertension. However, the mechanism by which fructose induces metabolic syndrome is largely unknown. We hypothesized that high fructose intake induces activation of the renin-angiotensin system (RAS), resulting in hypertension and metabolic syndrome. Read More

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http://dx.doi.org/10.4196/kjpp.2020.24.4.319DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7317175PMC

Diagnosis of Diabetes Mellitus in Older Adults.

Authors:
S Sethu K Reddy

Clin Geriatr Med 2020 Aug 18;36(3):379-384. Epub 2020 Apr 18.

CMED 2419, Central Michigan University, Mt. Pleasant, MI 48859, USA. Electronic address:

In the United States, 4 out of 10 adults with diabetes are ≥65 years of age. The older adult with diabetes is very likely to be asymptomatic and also at higher risk of vascular disease. New concerns include new diagnosis of diabetes for older adults admitted to hospital and older adults in long-term care facilities. Read More

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http://dx.doi.org/10.1016/j.cger.2020.04.011DOI Listing

Transient metabolic improvement in obese mice treated with navitoclax or dasatinib/quercetin.

Aging (Albany NY) 2020 Jun 25;12(12):11337-11348. Epub 2020 Jun 25.

Metabolic Syndrome Group - BIOPROMET, Madrid Institute for Advanced Studies - IMDEA Food, CEI UAM+CSIC, Madrid, Spain.

Senescent cells accumulate with obesity in the white adipose tissue of mice and humans. These senescent cells enhance the pro-inflammatory environment that, with time, contributes to the onset of glucose intolerance and type 2 diabetes. Glucose intolerance in mouse models of obesity has been successfully reversed by the elimination of senescent cells with the senolytic compounds navitoclax or the combination of dasatinib and quercetin (D/Q). Read More

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http://dx.doi.org/10.18632/aging.103607DOI Listing

Resolvin E1 derived from eicosapentaenoic acid prevents hyperinsulinemia and hyperglycemia in a host genetic manner.

FASEB J 2020 Jun 24. Epub 2020 Jun 24.

Department of Nutrition, Gillings School of Global Public Health and School of Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

Eicosapentaenoic acid (EPA) has garnered attention after the success of the REDUCE-IT trial, which contradicted previous conclusions on EPA for cardiovascular disease risk. Here we first investigated EPA's preventative role on hyperglycemia and hyperinsulinemia. EPA ethyl esters prevented obesity-induced glucose intolerance, hyperinsulinemia, and hyperglycemia in C57BL/6J mice. Read More

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http://dx.doi.org/10.1096/fj.202000830RDOI Listing

Effects of in vitro fertilization (IVF) therapies on metabolic, endocrine and inflammatory status in IVF-conceived pregnancy.

Clin Endocrinol (Oxf) 2020 Jun 23. Epub 2020 Jun 23.

Division of Biomedical Sciences (T.M.B.), Warwick Medical School, Clinical Sciences Research Laboratories, University Hospitals Coventry and Warwickshire, University of Warwick, Coventry, UK.

Rationale: In vitro fertilization (IVF) is a common treatment for infertility. In mice, IVF is associated with development of glucose intolerance. However, human data are limited regarding the metabolic, endocrine and inflammatory effects of IVF therapy in IVF-conceived pregnancies. Read More

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http://dx.doi.org/10.1111/cen.14270DOI Listing

Probiotic treatment for women with gestational diabetes to improve maternal and infant health and well-being.

Cochrane Database Syst Rev 2020 06 24;6:CD012970. Epub 2020 Jun 24.

Liggins Institute, The University of Auckland, Auckland, New Zealand.

Background: Gestational diabetes mellitus (GDM) is carbohydrate intolerance first recognised during pregnancy and associated with complications for mothers and babies. Probiotics are naturally occurring micro-organisms, which when ingested in adequate amounts, may confer health benefits. Evidence of the role of probiotics as treatment for GDM is limited. Read More

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http://dx.doi.org/10.1002/14651858.CD012970.pub2DOI Listing

Cigarette smoking blocks the benefit from reduced weight gain for insulin action by shifting lipids deposition to muscle.

Clin Sci (Lond) 2020 Jul;134(13):1659-1673

Lipid Biology and Metabolic Disease Laboratory, School of Health and Biomedical Sciences, RMIT University, Melbourne, VIC, Australia.

Cigarette smoking (CS) is known to reduce body weight and this often masks its real effect on insulin action. The present study tested the hypothesis that CS can divert lipid deposition to muscles to offset the supposed benefit of reduced body weight gain on insulin signalling in this major site for glucose tolerance (or insulin action). The study was conducted in mice exposed to chronic CS followed by either a chow (CH) diet or a high-fat (HF) diet. Read More

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http://dx.doi.org/10.1042/CS20200173DOI Listing

Dipeptidyl Peptidase-4 inhibitors use in type II diabetic patients in a tertiary hospital.

J Pharm Policy Pract 2020 18;13:34. Epub 2020 Jun 18.

Department of Pharmacy, Hospital Kuala Lumpur, Kuala Lumpur, Malaysia.

Background: In Malaysia, for more than a decade, dipeptidyl peptidase-4 inhibitors (DPP-4i) are among the oral antidiabetic medications used as monotherapy or in combination to manage type II diabetes mellitus (T2DM). These medications are known for the efficacy in glycated haemoglobin (HbA1c) reduction and weight neutral effect with minimal hypoglycaemia occurrence. This study aimed to identify the outcomes of DPP-4i use in one of the largest tertiary public hospital in Southeast Asia. Read More

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http://dx.doi.org/10.1186/s40545-020-00238-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7301996PMC

Sleep-disordered Breathing and Free Fatty Acid Metabolism.

Chest 2020 Jun 18. Epub 2020 Jun 18.

Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD.

Background: Sleep-disordered breathing (SDB) is independently associated with insulin resistance, glucose intolerance, and type 2 diabetes mellitus. However, the data on whether SDB alters metabolism of free fatty acids (FFA) are lacking.

Research Question: The primary objective of the current study was to characterize alterations in FFA metabolism across the spectrum of SDB severity. Read More

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http://dx.doi.org/10.1016/j.chest.2020.05.600DOI Listing

Leptin production capacity determines food intake and susceptibility to obesity-induced diabetes in Oikawa-Nagao Diabetes-Prone and Diabetes-Resistant mice.

Diabetologia 2020 Jun 19. Epub 2020 Jun 19.

Department of Endocrinology, Diabetes and Metabolism, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan.

Aims/hypothesis: Obesity caused by overeating plays a pivotal role in the development of type 2 diabetes. However, it remains poorly understood how individual meal size differences are determined before the development of obesity. Here, we investigated the underlying mechanisms in determining spontaneous food intake in newly established Oikawa-Nagao Diabetes-Prone (ON-DP) and Diabetes-Resistant (ON-DR) mice. Read More

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http://dx.doi.org/10.1007/s00125-020-05191-8DOI Listing

Identification of a periodontal pathogen and bihormonal cells in pancreatic islets of humans and a mouse model of periodontitis.

Sci Rep 2020 Jun 19;10(1):9976. Epub 2020 Jun 19.

Department of Periodontics, College of Dentistry, University of Illinois at Chicago, Chicago, Illinois, USA.

Results from epidemiological and prospective studies indicate a close association between periodontitis and diabetes. However the mechanisms by which periodontal pathogens influence the development of prediabetes/diabetes are not clear. We previously reported that oral administration of a periodontal pathogen, Porphyromonas gingivalis (Pg) to WT mice results in insulin resistance, hyperinsulinemia, and glucose intolerance and that Pg translocates to the pancreas. Read More

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http://dx.doi.org/10.1038/s41598-020-65828-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7305306PMC

Lactose Intolerance: What Your Breath Can Tell You.

Diagnostics (Basel) 2020 Jun 17;10(6). Epub 2020 Jun 17.

Department of Pharmaceutical Sciences, Massachusetts College of Pharmacy and Health Sciences University, Boston, MA 02115, USA.

Lactose intolerance has seen recognized as a clinical syndrome characterized by pain, abdominal distention, flatulence, and diarrhea after the consumption of lactose. Lactose is a common disaccharide found in dairy that requires lactase-phlorizin hydrolase (LPH) to break down into glucose and galactose. A deficiency in this enzyme results in flora bacteria further along in the gastrointestinal tract (GI) tract to metabolize the excess lactose to numerous gases, including H. Read More

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http://dx.doi.org/10.3390/diagnostics10060412DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7344825PMC

E-cigarettes damage the liver and alter nutrient metabolism in pregnant mice and their offspring.

Ann N Y Acad Sci 2020 Jun 17. Epub 2020 Jun 17.

School of Life Sciences, Faculty of Science, University of Technology Sydney, Sydney, New South Wales, Australia.

Approximately 15% of pregnant women vape electronic cigarettes (e-cigarettes), exposing the fetus to a range of toxic compounds, including nicotine and by-products of e-cigarette liquid (e-liquid) pyrolysis. Owing to the recent emergence of these products, research mainly focuses on immediate users, and not on in utero exposure. Therefore, this study aimed to understand the impact of intrauterine e-cigarette vapor (e-vapor) exposure, with and without nicotine, on liver metabolic markers in the male offspring. Read More

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http://dx.doi.org/10.1111/nyas.14411DOI Listing

Epithelial Mesenchymal Transition and Progression of Breast Cancer Promoted by Diabetes Mellitus in Mice Are Associated with Increased Expression of Glycolytic and Proteolytic Enzymes.

Horm Cancer 2020 Aug 16;11(3-4):170-181. Epub 2020 Jun 16.

Unidad de Morfología y Función, Facultad de Estudios Superiores Iztacala, Universidad Nacional Autónoma de México, Avenida de los Barrios 1, Los Reyes Ixtacala, 54090, Tlalnepantla, Estado de México, Mexico.

The development of breast cancer (BC) is influenced by age, overweight, obesity, metabolic syndrome, and diabetes mellitus (DM), which are associated with hyperglycemia, glucose intolerance, insulin resistance, and oxidative stress. High glucose concentration increases a metastatic phenotype in cultured breast cancer cells, promoting cell proliferation, reactive species production (ROS), epithelial mesenchymal transition (EMT), and expression of proteolytic enzymes. Our aim was to determine whether diabetes mellitus favor BC progression in mice and its association with changes in the content of ROS and glycolytic and proteolytic enzymes. Read More

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http://dx.doi.org/10.1007/s12672-020-00389-zDOI Listing

Exposure to Low Doses of Dechlorane Plus Promotes Adipose Tissue Dysfunction and Glucose Intolerance in Male Mice.

Endocrinology 2020 Aug;161(8)

Environmental Health Science and Research Bureau, Health Canada, 50 Colombine Driveway, Ottawa, Canada.

The prevalence of type 2 diabetes (T2D) continues to increase worldwide. It is well established that genetic susceptibility, obesity, overnutrition and a sedentary life style are risk factors for the development of T2D. However, more recently, studies have also proposed links between exposure to endocrine-disrupting chemicals (EDCs) and altered glucose metabolism. Read More

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http://dx.doi.org/10.1210/endocr/bqaa096DOI Listing

The relationship between total cholesterol and postpartum impaired glucose tolerance in women with gestational diabetes mellitus.

Lipids Health Dis 2020 Jun 18;19(1):142. Epub 2020 Jun 18.

Department of Obstetrics and Gynecology, The First Affiliated Hospital of Sun Yat-sen University, 58th, Zhongshan 2nd Road, Guangzhou, 510080, Guangdong, China.

Background: History of gestational diabetes mellitus (GDM) and serum lipid abnormalities were associated with postpartum impaired glucose tolerance. To investigate the association between concentration of total cholesterol (TC), at the time of GDM diagnosis, and risk of postpartum glucose intolerance.

Methods: Women who were diagnosed GDM with a live singleton delivery between January 1, 2013 and December 31, 2017 were included. Read More

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http://dx.doi.org/10.1186/s12944-020-01316-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7302143PMC

Inhibition of acetyl-CoA carboxylase by PP-7a exerts beneficial effects on metabolic dysregulation in a mouse model of diet-induced obesity.

Exp Ther Med 2020 Jul 29;20(1):521-529. Epub 2020 Apr 29.

Jiangsu Province Key Laboratory of New Drug Research and Clinical Pharmacy, School of Pharmacy, Xuzhou Medical University, Xuzhou, Jiangsu 221004, P.R. China.

Acetyl-coenzyme A carboxylase (ACC) is a critical regulator of fatty acid metabolism and represents a promising therapeutic target for metabolic diseases, including obesity, type 2 diabetes and non-alcoholic fatty liver disease. Recently, a novel ACC inhibitor, PP-7a, was developed by our group by utilizing a structure-based drug design. In the present study, the pharmacological effects of PP-7a on the metabolic dysregulation in mice with high-fat diet (HFD)-induced obesity and the underlying mechanisms were investigated. Read More

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http://dx.doi.org/10.3892/etm.2020.8700DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7296295PMC

Ginsenoside Rb1 Improves Cognitive Impairment Induced by Insulin Resistance through Cdk5/p35-NMDAR-IDE Pathway.

Biomed Res Int 2020 20;2020:3905719. Epub 2020 May 20.

Department of Emergency, Jining No. 1 People's Hospital, Jining Medical University, Jining, Shandong, China.

The relationship between diabetes mellitus (DM) and Alzheimer's disease (AD) has attracted wide attention. Studies have reported that ginsenoside Rb1 can improve human cognitive ability and glucose tolerance during the development of diabetes. The mechanism behind the improvement in cognitive ability and glucose tolerance still remains unclear. Read More

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http://dx.doi.org/10.1155/2020/3905719DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7256773PMC

High-dose thiamine supplementation may reduce resting energy expenditure in individuals with hyperglycemia: a randomized, double - blind cross-over trial.

J Diabetes Metab Disord 2020 Jun 22;19(1):297-304. Epub 2020 Feb 22.

School of Public Health, Curtin University, Perth, Western Australia 6102 Australia.

Background: Despite the crucial role of thiamine in glucose and energy metabolism pathways, there has been no published study examining the impact of thiamine on energy metabolism in humans.

Objective: To assess the effects of thiamine supplementation on resting energy expenditure (REE) in individuals with hyperglycemia.

Methods: Twelve hyperglycemic patients completed this double-blind, randomized trial, where all participants received both thiamine (300 mg/day) and matched placebo for 6 weeks in a cross-over manner. Read More

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http://dx.doi.org/10.1007/s40200-020-00508-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7271085PMC

Profile of Overweight and Obesity in Children and Adolescents and Frequency of Type 2 Diabetes Mellitus and Glucose Intolerance: A Study in Public School in Brazil.

Diabetes Metab Syndr Obes 2020 21;13:1733-1741. Epub 2020 May 21.

Nursing Course ABC Medical School Foundation, Santo André, SP, Brazil.

Objective: To verify if there is an increase in frequency of type 2 diabetes mellitus (DM2) and glucose intolerance in children and adolescents who are overweight and obese.

Methods: This was a cross-sectional survey. The study population consisted of 2757 students of both sexes (1415 girls and 1342 boys) attending public schools in São Paulo state, Brazil,aged 10-19 years, from 2011 to 2012. Read More

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http://dx.doi.org/10.2147/DMSO.S246061DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7247719PMC

Fish oil supplementation alleviates metabolic and anxiodepressive effects of diet-induced obesity and associated changes in brain lipid composition in mice.

Int J Obes (Lond) 2020 Jun 16. Epub 2020 Jun 16.

Centre de Recherche du CHUM and Montreal Diabetes Research Center, Montreal, QC, H2X 0A9, Canada.

Objective: Obesity significantly elevates the odds of developing mood disorders. Chronic consumption of a saturated high-fat diet (HFD) elicits anxiodepressive behavior in a manner linked to metabolic dysfunction and neuroinflammation in mice. Dietary omega-3 polyunsaturated fatty acids (n-3 PUFA) can improve both metabolic and mood impairments by relieving inflammation. Read More

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http://dx.doi.org/10.1038/s41366-020-0623-6DOI Listing

Disrupting phosphatase SHP2 in macrophages protects mice from high-fat diet-induced hepatic steatosis and insulin resistance by elevating IL-18 levels.

J Biol Chem 2020 Jun 16. Epub 2020 Jun 16.

Nanjing University, China.

Chronic low-grade inflammation plays an important role in the pathogenesis of type 2 diabetes. Src homology 2 domain-containing tyrosine phosphatase-2 (SHP2) has been reported to play diverse roles in different tissues during the development of metabolic disorders. We previously reported that SHP2 inhibition in macrophages results in increased cytokine production. Read More

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http://dx.doi.org/10.1074/jbc.RA119.011840DOI Listing
June 2020
4.573 Impact Factor

Arsenic induces hepatic insulin resistance via mtROS-NLRP3 inflammasome pathway.

J Hazard Mater 2020 Jun 4;399:123034. Epub 2020 Jun 4.

Occupational and Environmental Health Department, Dalian Medical University, 9 Lvshun South Road, Dalian, 116044, PR China; Global Health Research Center, Dalian Medical University, 9 Lvshun South Road, Dalian, 116044, PR China. Electronic address:

Hepatic insulin resistance (IR) is the key event for arsenic-caused type 2 diabetes (T2D). However, the unequivocal mechanism of arsenic-induced hepatic IR remains unclear. The current study determined the role of NOD-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome activation in arsenic-induced IR and revealed the underlying mechanism. Read More

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http://dx.doi.org/10.1016/j.jhazmat.2020.123034DOI Listing

Lean body mass is not beneficial, but may be detrimental for glucose tolerance - Splitting body mass index according to body composition.

Prim Care Diabetes 2020 Jun 10. Epub 2020 Jun 10.

Department of General Practice and Primary Health Care, University of Helsinki and Helsinki University Hospital, 00100 Helsinki, Finland; Folkhälsan Research Center, 00250 Helsinki, Finland; National Institute for Health and Welfare, 00271 Helsinki, Finland; National University of Singapore, Yong Loo Lin School of Medicine, Department of Obstetrics and Gynecology, 1E Kent Ridge Road, Singapore 119228, Singapore. Electronic address:

Aims: To study the combined effect of lean mass index (LMI) and fat mass index (FMI) on glucose regulation based upon findings in an oral glucose tolerance test (OGTT) and homeostasis model assessment of insulin resistance (HOMA-IR).

Methods: We conducted a population-based, cross-sectional study including 1617 participants without diabetes born in Helsinki from 1934 through 1944. LMI and FMI were calculated as lean and fat mass (kg)/height (m). Read More

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http://dx.doi.org/10.1016/j.pcd.2020.05.003DOI Listing