Acute, but not Chronic, Exposure to Arsenic Provokes Glucose Intolerance in Rats: Possible Roles for Oxidative Stress and the Adrenergic Pathway.
- Mohsen Rezaei,
- Mohammd Javad Khodayar,
- Enayatollah Seydi,
- Alboghobeish Soheila,
- Isa Kazemzadeh Parsi
Can J Diabetes 2017 Feb 21. Epub 2017 Feb 21.
Department of Pharmacology and Toxicology, School of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Objectives: Health problems due to heavy metals have become a worldwide concern. Along with its carcinogenicity, arsenic exposure results in impairment of glucose metabolism and insulin secretion as well as altered gene expression and signal transduction. However, the exact mechanism behind the behaviour of arsenic on glucose homeostasis and insulin secretion has not yet been fully understood. Read More