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    Testosterone is protective against impaired glucose metabolism in male intrauterine growth-restricted offspring.
    PLoS One 2017 16;12(11):e0187843. Epub 2017 Nov 16.
    Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS, United States of America.
    Placental insufficiency alters the intrauterine environment leading to increased risk for chronic disease including impaired glucose metabolism in low birth weight infants. Using a rat model of low birth weight, we previously reported that placental insufficiency induces a significant increase in circulating testosterone in male intrauterine growth-restricted offspring (mIUGR) in early adulthood that is lost by 12 months of age. Numerous studies indicate testosterone has a positive effect on glucose metabolism in men. Read More

    Honokiol protects pancreatic β cell against high glucose and intermittent hypoxia-induced injury by activating Nrf2/ARE pathway in vitro and in vivo.
    Biomed Pharmacother 2017 Nov 13;97:1229-1237. Epub 2017 Nov 13.
    Key Laboratory of Hormones and Development (Ministry of Health), Tianjin Key Laboratory of Metabolic Diseases, Tianjin Metabolic Diseases Hospital & Tianjin Institute of Endocrinology, Tianjin Medical University, 300070 Tianjin, China.
    Obstructive sleep apnea hypopnea syndrome (OSAHS) is associated with glucose intolerance, insulin resistance and type 2 diabetes mellitus (T2DM). Although several studies have revealed that intermittent hypoxia (IH) in OSAHS may further aggravate pancreatic β cell damage and promote the evolution of type 2 diabetes (T2DM) by increasing oxidative stress, the underlying mechanisms are unclear. Honokiol, a potent radical scavenger, has been demonstrated to ameliorate oxidative stress in many cases. Read More

    Glucose tolerance study in low and normal birth weight young adults.
    Cent Afr J Med 2013 May-Aug;59(5-8):38-42
    Objective: To determine blood glucose levels by conducting an oral glucose tolerance test in low and normal birth weight young black adults.

    Design: Acase control study was done. Seventy students in the College of Health Sciences who had neonatal clinic cards as proof of birth weight were recruited into the study. Read More

    Successful glycemic control using a flash glucose monitoring system for a pregnant woman with diabetes: a case report.
    J Diabetes Metab Disord 2017 6;16:44. Epub 2017 Nov 6.
    Clinical Research Center, Department of Medicine, International University of Health and Welfare, Tokyo, Japan.
    Background: Glucose control for pregnant women with glucose intolerance is important, as hyperglycemia may adversely affect the mother and the fetus.

    Case Presentation: We report the case of a pregnant Japanese woman who experienced gestational diabetes mellitus during her first pregnancy and developed impaired glucose tolerance after the delivery. During her second pregnancy with twins, she required up to 75 units of injected insulin to control her postprandial hyperglycemia and occasionally experienced hypoglycemia. Read More

    Muscle glycogen synthesis and breakdown are both impaired in glycogenin-1 deficiency.
    Neurology 2017 Nov 15. Epub 2017 Nov 15.
    From the Copenhagen Neuromuscular Center (M.G.S., K.L.M., A.E.B., J.V.), Department of Neurology, Rigshospitalet, University of Copenhagen, Denmark; and Paris-Est Neuromuscular Center (P.L.), Université Pierre et Marie Curie, Hôpital Pitié-Salpêtrière, France.
    Objective: To study fat and carbohydrate metabolism during exercise in patients with glycogenin-1 (GYG1) deficiency, and to study whether IV glucose supplementation can alleviate exercise intolerance in these patients.

    Methods: This is a case-control study with 4 patients with GYG1 deficiency and 4 healthy controls. Patients performed 1 hour of cycling at 50% of their maximal workload capacity, while controls cycled at the same absolute workloads as patients. Read More

    Androgen signaling expands β-cell mass in male rats and β-cell androgen receptor is degraded under high-glucose conditions.
    Am J Physiol Endocrinol Metab 2017 Nov 14:ajpendo.00211.2017. Epub 2017 Nov 14.
    Osaka Prefecture University.
    A deficient pancreatic β-cell mass increases the risk of type 2 diabetes mellitus. Here, we investigated the effects of testosterone on the development of pancreatic β-cell mass in male rats. The β-cell mass of male rats castrated at 6 weeks of age was reduced to ~30% of that of control rats at 16 weeks of age, and castration caused glucose intolerance. Read More

    Assessing the consequences of gestational diabetes mellitus on offspring's cardiovascular health: MySweetHeart Cohort study protocol, Switzerland.
    BMJ Open 2017 Nov 14;7(11):e016972. Epub 2017 Nov 14.
    Paediatric Cardiology Unit, Woman-Mother-Child Department, Lausanne University Hospital, Lausanne, Switzerland.
    Introduction: Gestational diabetes mellitus (GDM) is a state of glucose intolerance with onset during pregnancy. GDM carries prenatal and perinatal risks as well as long-term risks for the mother and her child. GDM may be involved in the foetal programming of long-term cardiovascular health. Read More

    Dietary Pea Fiber Supplementation Improves Glycemia and Induces Changes in the Composition of Gut Microbiota, Serum Short Chain Fatty Acid Profile and Expression of Mucins in Glucose Intolerant Rats.
    Nutrients 2017 Nov 12;9(11). Epub 2017 Nov 12.
    Department of Physiology, University of Alberta, Edmonton, AB T6G 2H7, Canada.
    Several studies have demonstrated the beneficial impact of dried peas and their components on glucose tolerance; however, the role of gut microbiota as a potential mediator is not fully examined. In this study, we investigated the effect of dietary supplementation with raw and cooked pea seed coats (PSC) on glucose tolerance, microbial composition of the gut, select markers of intestinal barrier function, and short chain fatty acid profile in glucose intolerant rats. Male Sprague Dawley rats were fed high fat diet (HFD) for six weeks to induce glucose intolerance, followed by four weeks of feeding PSC-supplemented diets. Read More

    cTAGE5 deletion in pancreatic β cells impairs proinsulin trafficking and insulin biogenesis in mice.
    J Cell Biol 2017 Nov 13. Epub 2017 Nov 13.
    State Key Laboratory of Molecular Developmental Biology, CAS Center for Excellence in Brain Science and Intelligence Technology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China
    Proinsulin is synthesized in the endoplasmic reticulum (ER) in pancreatic β cells and transported to the Golgi apparatus for proper processing and secretion into plasma. Defects in insulin biogenesis may cause diabetes. However, the underlying mechanisms for proinsulin transport are still not fully understood. Read More

    Elevated HuR in Pancreas Promotes a Pancreatitis-like Inflammatory Microenvironment that Facilitates Tumor Development.
    Mol Cell Biol 2017 Nov 13. Epub 2017 Nov 13.
    Lankenau Institute for Medical Research, Wynnewood, Pennsylvania, USA
    Human antigen R (ELAVL1, HuR) is perhaps the best-characterized RNA-binding protein. Through its overexpression in various tumor types, HuR promotes post-transcriptional regulation of target genes in multiple core signaling pathways associated with tumor progression. The role of HuR overexpression in pancreatic tumorigenesis is unknown and led us to explore the consequences of HuR overexpression using a novel transgenic mouse model that has a >2-fold elevation of pancreatic HuR expression. Read More

    The role of artificial and natural sweeteners in reducing the consumption of table sugar: A narrative review.
    Clin Nutr ESPEN 2017 Apr 4;18:1-8. Epub 2017 Feb 4.
    Department of Cell Physiology, Faculty of Medicine, Kagawa University, Kagawa, Japan.
    The rapid increase in the prevalence of obesity worldwide has been partially attributed to the overconsumption of added sugars. Recent guidelines call for limiting the consumption of simple sugars to less than 10% of daily caloric consumption. High intensity sweeteners are regulated as food additives and include aspartame, acesulfame-k, neotame, saccharin, sucralose, cyclamate and alitame. Read More

    NFIL3 is a negative regulator of hepatic gluconeogenesis.
    Metabolism 2017 Dec 31;77:13-22. Epub 2017 Aug 31.
    Division of Life Sciences, Korea University, 145 Anam-Ro, Seongbuk-Gu, Seoul 02841, Republic of Korea. Electronic address:
    Objective: Nuclear factor interleukin-3 regulated (NFIL3) has been known as an important transcriptional regulator of the development and the differentiation of immune cells. Although expression of NFIL3 is regulated by nutritional cues in the liver, the role of NFIL3 in the glucose metabolism has not been extensively studied. Thus, we wanted to explore the potential role of NFIL3 in the control of hepatic glucose metabolism. Read More

    [Association between birth weight and cardiometabolic risk factors in children of Bucaramanga, Colombia>].
    Nutr Hosp 2017 Oct 24;34(5):1105-1111. Epub 2017 Oct 24.
    Universidad Industrial de Santander. Bucaramanga, Colombia.
    Background: Birth weight could be a medium-term risk factor in the development of overweight and obesity and a long-term risk factor of cardio-metabolic diseases.

    Objective: To evaluate the association between birth weight and cardio-metabolic risk factors in children from Bucaramanga, Colombia.

    Methods: This cross-sectional study included 1,282 children between five and eleven years of age in Bucaramanga. Read More

    Co-supplementation of isomalto-oligosaccharides potentiates metabolic health benefits of polyphenol-rich cranberry extract in high fat diet-fed mice via enhanced gut butyrate production.
    Eur J Nutr 2017 Nov 10. Epub 2017 Nov 10.
    Food and Nutrition Biotechnology Division, National Agri-Food Biotechnology Institute (NABI), Sector-81, Knowledge City, S.A.S. Nagar, P.O.- Manauli, Mohali, Punjab, 140306, India.
    Purpose: Cranberries are a rich source of polyphenolic antioxidants. Purified sugars or artificial sweeteners are being added to cranberry-based food products to mask tartness. Refined sugar and artificial sweeteners intake modulate gut microbiota and result in metabolic complications. Read More

    BRD7 regulates the insulin-signaling pathway by increasing phosphorylation of GSK3β.
    Cell Mol Life Sci 2017 Nov 10. Epub 2017 Nov 10.
    Division of Endocrinology, Boston Children's Hospital, Harvard Medical School, Boston, MA, 02115, USA.
    Reduced hepatic expression levels of bromodomain-containing protein 7 (BRD7) have been suggested to play a role in the development of glucose intolerance in obesity. However, the molecular mechanism by which BRD7 regulates glucose metabolism has remained unclear. Here, we show that BRD7 increases phosphorylation of glycogen synthase kinase 3β (GSK3β) in response to activation of the insulin receptor-signaling pathway shortly after insulin stimulation and the nutrient-sensing pathway after feeding. Read More

    Adiponectin Concentration in Gestational Diabetic Women: a Case-Control Study.
    Clin Nutr Res 2017 Oct 27;6(4):267-276. Epub 2017 Oct 27.
    Department of Clinical Nutrition, School of Nutrition and Food Sciences, Isfahan University of Medical Sciences, Isfahan 81746-73461, Iran.
    Gestational diabetes mellitus (GDM) is an impaired fasting glucose condition during pregnancy. Adiponectin is a polypeptide hormone that is extensively released by adipocytes which regulates energy homeostasis and carbohydrate and lipid metabolism. In addition, adiponectin has antidiabetic and anti-inflammatory properties. Read More

    Naringin prevents HIV-1 protease inhibitors-induced metabolic complications in vivo.
    PLoS One 2017 9;12(11):e0183355. Epub 2017 Nov 9.
    Molecular and Clinical Pharmacology Research Laboratory, Department of Pharmacology, Discipline of Pharmaceutical Science, School of Health Sciences, University of KwaZulu-Natal, Westville, Durban, South Africa.
    Background: Insulin resistance, glucose intolerance and overt diabetes are known metabolic complications associated with chronic use of HIV-Protease Inhibitors. Naringin is a grapefruit-derived flavonoid with anti-diabetic, anti-dyslipidemia, anti-inflammatory and anti-oxidant activities.

    Objectives: The study investigated the protective effects of naringin on glucose intolerance and impaired insulin secretion and signaling in vivo. Read More

    Maternal high-fat diet impairs glucose metabolism, β-cell function and proliferation in the second generation of offspring rats.
    Nutr Metab (Lond) 2017 2;14:67. Epub 2017 Nov 2.
    Department of Endocrinology, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, 1665 Kongjiang Road, Shanghai, 200092 China.
    Background: This study aimed to assess the impact of perinatal high-fat (HF) diet in female Sprague-Dawley rats (F0) on glucose metabolism and islet function in their early life of second-generation of offspring (F2).

    Methods: F0 rats were fed with a standard chow (SC) or HF diet for 8 weeks before mating, up to termination of lactation for their first-generation of offspring (F1-SC and F1-HF). F1 females were mated with normal males at the age of week 11, and producing F2 offspring (F2-SC, F2-HF). Read More

    Arsenic Exposure Induces Glucose Intolerance and Alters Global Energy Metabolism.
    Am J Physiol Regul Integr Comp Physiol 2017 Nov 8:ajpregu.00522.2016. Epub 2017 Nov 8.
    University of Illinois at Chicago
    Environmental pollutants acting as endocrine disrupting chemicals (EDCs) are recognized as potential contributors to metabolic disease pathogenesis. One such pollutant, arsenic, contaminates the drinking water of approximately 100 million people globally and has been associated with insulin resistance and diabetes in epidemiological studies. Despite these observations, the precise metabolic derangements induced by arsenic remain incompletely characterized. Read More

    The Effects of a Modified High-carbohydrate High-fat Diet on Metabolic Syndrome Parameters in Male Rats.
    Exp Clin Endocrinol Diabetes 2017 Nov 8. Epub 2017 Nov 8.
    Department of Pharmacology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Yaakob Latif, Bandar Tun Razak, 56000 Cheras, Kuala Lumpur, Malaysia.
    Metabolic syndrome is a cluster of metabolic abnormalities including central obesity, hyperglycemia, hypertension, and dyslipidemia. A previous study has established that high-carbohydrate high-fat diet (HCHF) can induce MetS in rats. In this study, we modified components of the diet so that it resembled the diet of Southeast Asians. Read More

    Dietary Uncoupling of Gut Microbiota and Energy Harvesting from Obesity and Glucose Tolerance in Mice.
    Cell Rep 2017 Nov;21(6):1521-1533
    Rowett Institute, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, UK. Electronic address:
    Evidence suggests that altered gut microbiota composition may be involved in the development of obesity. Studies using mice made obese with refined high-fat diets have supported this; however, these have commonly used chow as a control diet, introducing confounding factors from differences in dietary composition that have a key role in shaping microbiota composition. We compared the effects of feeding a refined high-fat diet with those of feeding either a refined low-fat diet or a chow diet on gut microbiota composition and host physiology. Read More

    Unclassified hepatocellular adenoma in a middle-aged woman with glucose intolerance.
    Clin J Gastroenterol 2017 Nov 7. Epub 2017 Nov 7.
    Department of Radiology, Fukui Prefectural Hospital, 2-8-1 Yotsui, Fukui, Japan.
    The patient was a 43-year-old woman with obesity (body mass index: 29.1) and glucose intolerance who was not taking oral contraceptives. An ultrasound showed a hypoechoic hepatic mass. Read More

    Relationship between exercise capacity and glucose tolerance in cystic fibrosis.
    Pediatr Pulmonol 2017 Nov 8. Epub 2017 Nov 8.
    Division of Endocrinology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
    Background: Improved exercise capacity (EC) and normal glucose tolerance (NGT) are independently associated with favorable outcomes in CF, however, little information on this relationship exists in patients with CF.

    Methods: Cardiopulmonary exercise tests, oral glucose tolerance tests (OGTT), and HbA1c values measured within a 12-month period were evaluated on 83 pediatric patients diagnosed with CF. Patients were categorized as having NGT, abnormal glucose tolerance (AGT), or CF-related diabetes (CFRD). Read More

    Hepatocyte-Specific Deletion of BAP31 Promotes SREBP1C Activation, Promotes Hepatic Lipid Accumulation, and Worsens Insulin Resistance in Mice.
    J Lipid Res 2017 Nov 7. Epub 2017 Nov 7.
    Northeastern University, China
    Conditional knockout mice with targeted disruption of BAP31 in adult mouse liver were generated and challenged with a high-fat diet (HFD) for 36 or 96 days, markers of obesity, diabetes, and hepatic steatosis were determined. Mutant mice were indistinguishable from wild-type littermates, but exhibited increased HFD-induced obesity. BAP31-deletion in hepatocytes increased the expression of SREBP1C and the target genes, including ACC1 and SCD1, increased hepatic lipid accumulation and HFD-induced liver steatosis. Read More

    Nox4 genetic inhibition in experimental hypertension and metabolic syndrome.
    Arch Cardiovasc Dis 2017 Nov 4. Epub 2017 Nov 4.
    Institut clinique de la Souris, institut de génétique et de biologie moléculaire et cellulaire, université de Strasbourg, Illkirch, France; Laboratoire de neurobiologie et pharmacologie cardiovasculaire, faculté de médecine, fédération de médecine translationnelle, université, CHU de Strasbourg, 11, rue Humann, 67085 Strasbourg cedex, France. Electronic address:
    Background: Metabolic syndrome is a combination of symptoms including obesity, dyslipidaemia, glucose intolerance and hypertension. Oxidative stress appears to be a pathophysiological factor that links these signs and encourages progression towards heart failure and diabetes. Nox4 is a hydrogen peroxide nicotinamide adenine dinucleotide phosphate (NADPH) oxidase isoform - found in various cardiovascular cells and tissues, but also in tissues such as the liver - which is involved in glucose and lipid homeostasis. Read More

    Circulating B-type Natriuretic Peptide in Women with and without Recent Gestational Diabetes:The Impact of Current Glucose Intolerance.
    Clin Endocrinol (Oxf) 2017 Nov 7. Epub 2017 Nov 7.
    Leadership Sinai Centre for Diabetes, Mount Sinai Hospital, Toronto, Canada.
    Context: Circulating B-type natriuretic peptide, as measured by the N-terminal fragment of its prohormone (NT-proBNP), is inversely associated with incident type 2 diabetes (T2DM) but positively related to future cardiovascular disease (CVD). Recognizing that gestational diabetes (GDM) identifies women at future risk for both T2DM and CVD, we sought to determine whether gestational glucose tolerance relates to NT-proBNP in the years after delivery.

    Design/patients/measurements: Three-hundred-and-forty women underwent a glucose challenge test (GCT) and an oral glucose tolerance test (OGTT) in pregnancy, yielding 4 gestational glucose tolerance groups: GDM (n=105); gestational impaired glucose tolerance (n=59); abnormal GCT with a normal OGTT (n=98); and normal GCT with normal OGTT (n=75). Read More

    Associated conditions in small fiber neuropathy - A large cohort study and review of the literature.
    Eur J Neurol 2017 Nov 7. Epub 2017 Nov 7.
    Department of Neurology, School of Mental Health and Neuroscience, Maastricht University Medical Center, Maastricht, The Netherlands.
    Background: Small fiber neuropathy (SFN) is a common disorder, leading to neuropathic pain and autonomic symptoms. The objective of this study was to investigate associated conditions in a large cohort of SFN patients and compare the prevalence to healthy individuals.

    Methods: A total of 921 patients with pure SFN were screened according to a standardized comprehensive diagnostic algorithm and compared with literature findings. Read More

    Clinical characteristics of schoolchildren with renal glucosuria.
    Pediatr Int 2017 Nov 7. Epub 2017 Nov 7.
    Department of Pediatrics, Nihon University School of Medicine, Tokyo, Japan.
    Background: We have conducted an annual urine glucose screening program at schools, and diagnosed schoolchildren with diabetes at an early stage of the disease. We also identified some cases with renal glucosuria (RG), based on positive urine glucose with normal glucose tolerance.

    Methods: During the period from 2000 to 2015, 3, 309, 631 schoolchildren participated in the screening program. Read More

    NHE3 Blockade Ameliorates Type 2 Diabetes Mellitus via Inhibition of SGLT1-Mediated Glucose Absorption in the Small Intestine.
    Diabetes Obes Metab 2017 Nov 7. Epub 2017 Nov 7.
    School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China.
    Aim: Na(+) /H(+) exchanger 3 (NHE3) is an exchanger localized to the small intestinal brush border membrane (BBM). Here, we unraveled the role of NHE3 in SGLT1-mediated small intestinal BBM glucose absorption and functional implication in type 2 diabetes mellitus (T2DM).

    Materials And Methods: Human jejunal samples were obtained from patients undergoing gastrectomy. Read More

    Host-microbiota interaction induces bi-phasic inflammation and glucose intolerance in mice.
    Mol Metab 2017 Nov 21;6(11):1371-1380. Epub 2017 Sep 21.
    Wallenberg Laboratory, Department of Molecular and Clinical Medicine and Sahlgrenska Center for Cardiovascular and Metabolic Research, University of Gothenburg, 413 45 Gothenburg, Sweden; Novo Nordisk Foundation Center for Basic Metabolic Research and Section for Metabolic Receptology and Enteroendocrinology, Faculty of Health Sciences, University of Copenhagen, Copenhagen 2200, Denmark. Electronic address:
    Objective: Gut microbiota modulates adiposity and glucose metabolism in humans and mice. Here we investigated how colonization of germ-free (GF) mice affects kinetics of adiposity and glucose metabolism.

    Methods: Adiposity and glucose metabolism were evaluated at different time points in ex-GF and antibiotic treated mice after colonization with gut microbiota from a conventionally raised (CONV-R) mouse. Read More

    [Diabetes Mellitus, a prothrombotic disease].
    Ann Cardiol Angeiol (Paris) 2017 Oct 26. Epub 2017 Oct 26.
    Interventional cardiology department, Cochin hospital, Assistance publique-Hôpitaux de Paris, 27, rue du Faubourg-Saint-Jacques, 75014 Paris, France; Université Paris Descartes, université Sorbonne Paris Cité, 75006 Paris, France. Electronic address:
    In patients with acute atherothrombotic disease, diabetes or glucose intolerance is frequently found. Indeed, the number of people with diabetes in the world continues to increase and is expected to reach more than 500 million people by 2035. Diabetes is a pathology commonly associated with both microvascular and macrovascular complications. Read More

    Non-motor manifestations in ALS patients with tracheostomy and invasive ventilation.
    Muscle Nerve 2017 Nov 3. Epub 2017 Nov 3.
    Department of Neurology, Tokyo Metropolitan Neurological Hospital, Tokyo, Japan.
    Introduction: This study aimed to investigate non-motor manifestations in amyotrophic lateral sclerosis (ALS) patients with tracheostomy and invasive ventilation (TIV) and their relevance to disease progression.

    Methods: Sixty-seven ALS patients with TIV were enrolled, and followed-up prospectively. The patients were classified at the final evaluation into two subgroups according to the duration of TIV use or disease stage measured by communication impairment. Read More

    Specific Physical Exercise Improves Energetic Metabolism in the Skeletal Muscle of Amyotrophic-Lateral- Sclerosis Mice.
    Front Mol Neurosci 2017 20;10:332. Epub 2017 Oct 20.
    Sorbonne Paris Cité, Faculté des Sciences Fondamentales et Biomédicales, Université Paris Descartes, Paris, France.
    Amyotrophic Lateral Sclerosis is an adult-onset neurodegenerative disease characterized by the specific loss of motor neurons, leading to muscle paralysis and death. Although the cellular mechanisms underlying amyotrophic lateral sclerosis (ALS)-induced toxicity for motor neurons remain poorly understood, growing evidence suggest a defective energetic metabolism in skeletal muscles participating in ALS-induced motor neuron death ultimately destabilizing neuromuscular junctions. In the present study, we report that a specific exercise paradigm, based on a high intensity and amplitude swimming exercise, significantly improves glucose metabolism in ALS mice. Read More

    Normal diet Vs High fat diet - A comparative study: Behavioral and neuroimmunological changes in adolescent male mice.
    Metab Brain Dis 2017 Nov 3. Epub 2017 Nov 3.
    State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, 210009, China.
    Recent evidence has established that consumption of High-fat diet (HFD)-induced obesity is associated with deficits in hippocampus-dependent memory/learning and mood states. Nevertheless the link between obesity and emotional disorders still remains to be elucidated. This issue is of particular interest during adolescence, which is important period for shaping learning/memory and mood regulation that can be sensitive to the detrimental effects of HFD. Read More

    Loss of microRNA-22 prevents high fat diet induced dyslipidemia and increases energy expenditure without affecting cardiac hypertrophy.
    Clin Sci (Lond) 2017 Nov 3. Epub 2017 Nov 3.
    Cardiology, Boston Children's Hospital and Harvard Medical School, 300 Longwood Ave, Boston, Massachusetts, United States
    Obesity is associated with development of diverse diseases, including cardiovascular diseases and dyslipidemia. MiRNA-22 (miR-22) is a critical regulator of cardiac function and targets genes involved in metabolic processes. Previously we generated miR-22 null mice and we showed that loss of miR-22 blunted cardiac hypertrophy induced by mechanohormornal stress. Read More

    Change in nonhigh-density lipoprotein cholesterol levels in adults with prediabetes.
    Medicine (Baltimore) 2017 Nov;96(44):e8461
    Department of Endocrinology, The First Hospital of Qinhuangdao, Hebei Medical University, Qinhuangdao, Hebei Province, China.
    This study aimed to observe the change in nonhigh-density lipoprotein cholesterol (non-HDL-C) levels and analyzed its related factors in adults with prediabetes (impaired fasting glucose and/or impaired glucose tolerance).This case-controlled study included 56 adults with normal glucose tolerance (NGT) and 74 adults with prediabetes. The cases and controls were age and gender-matched. Read More

    Anti-obesity Effect of Halophyte Crop, Limonium tetragonum in High-Fat Diet-Induced Obese Mice and 3T3-L1 Adipocytes.
    Biol Pharm Bull 2017 ;40(11):1856-1865
    Department of Agronomy and Medicinal Plant Resources, Gyeongnam National University of Science and Technology.
    Halophyte Limonium tetragonum has recently been of interest in Korea for its nutritional value and salty taste which made it an ideal vegetable. In this study, the potential of L. tetragonum preventing excess weight gain, obesity and the related health problem has been evaluated in vitro and in vivo. Read More

    Uncoupling Exercise Bioenergetics from Systemic Metabolic Homeostasis by Conditional Inactivation of Baf60 in Skeletal Muscle.
    Diabetes 2017 Nov 1. Epub 2017 Nov 1.
    Life Sciences Institute and Department of Cell & Developmental Biology, University of Michigan Medical Center, Ann Arbor, MI 48109
    Impaired skeletal muscle energy metabolism is linked to the pathogenesis of insulin resistance and glucose intolerance in type 2 diabetes. The contractile and metabolic properties of myofibers exhibit a high degree of heterogeneity and plasticity. The regulatory circuitry underpinning skeletal muscle energy metabolism is critically linked to exercise endurance and systemic homeostasis. Read More

    Skeletal muscle and fetal alcohol spectrum disorder.
    Biochem Cell Biol 2017 Nov 1. Epub 2017 Nov 1.
    University of Manitoba, 8664, Human Nutritional Sciences, Winnipeg, Manitoba, Canada ;
    Skeletal muscle is critical for mobility and many metabolic functions integral to survival and long-term health. Alcohol can affect skeletal muscle physiology and metabolism, which will have immediate and long-term consequences on health. While skeletal muscle abnormalities, including morphological, biochemical and functional impairments are well documented in adults consuming excessive alcohol, there is a scarcity of information about skeletal muscle in the prenatal alcohol exposure (PAE) offspring. Read More

    Comparison between pre-exercise casein peptide and intact casein supplementation on glucose tolerance in high-fat diet-fed mice.
    Appl Physiol Nutr Metab 2017 Nov 1. Epub 2017 Nov 1.
    The University of Tokyo, Department of Sports Sciences, Tokyo, Japan ;
    We hypothesized that along with exercise, casein peptide supplementation would have a higher impact on improving glucose tolerance than intact casein. Male six-week-old ICR mice were provided a high-fat diet to induce obesity and glucose intolerance. The mice were randomly divided into four treatment groups: control (Con), endurance training (Tr), endurance training with intact casein supplementation (Cas+Tr), and endurance training with casein peptide supplementation (CP+Tr). Read More

    Apple Cider Vinegar Attenuates Oxidative Stress and Reduces the Risk of Obesity in High-Fat-Fed Male Wistar Rats.
    J Med Food 2017 Nov 1. Epub 2017 Nov 1.
    1 Research Unit on Nutrition, Regulation of Metabolic Systems and Atherosclerosis, High School of Health Sciences, University of Tunis El Manar , Tunis, Tunisia .
    Metabolic syndrome is a serious consequence of obesity characterized by increased cardiovascular risk factors such as hypertension, dyslipidemia, and glucose intolerance. While diets enriched with natural antioxidants showed beneficial effects on oxidative stress, blood pressure, and serum lipid composition, diet supplementation with synthetic antioxidants showed contradictive results. Thus, we tested, in this study, whether a daily dosage of Apple Cider Vinegar (ACV) would affect cardiovascular risk factor associated with obesity in high-fat diet (HFD)-induced hyperlipidemic Wistar rats. Read More

    Dnmt3a is an epigenetic mediator of adipose insulin resistance.
    Elife 2017 Nov 1;6. Epub 2017 Nov 1.
    Nutritional Sciences and Toxicology Department, University of California, Berkeley, Berkeley, United States.
    Insulin resistance results from an intricate interaction between genetic make-up and environment, and thus may be orchestrated by epigenetic mechanisms like DNA methylation. Here, we demonstrate that DNA methyltransferase 3a (Dnmt3a) is both necessary and sufficient to mediate insulin resistance in cultured mouse and human adipocytes. Furthermore, adipose-specific Dnmt3a knock-out mice are protected from diet-induced insulin resistance and glucose intolerance without accompanying changes in adiposity. Read More

    Antioxidant, antihyperglycemic, and antidyslipidemic effects of Brazilian-native fruit extracts in an animal model of insulin resistance.
    Redox Rep 2017 Oct 31:1-6. Epub 2017 Oct 31.
    a Laboratório de Biomarcadores, Centro de Ciências Químicas, Farmacêuticas e de Alimentos , Universidade Federal de Pelotas , Pelotas , Brazil.
    Objective: Insulin resistance (IR) plays an important role in the development of many diseases, such as diabetes mellitus. Therefore, the aim of the present study was to evaluate the effects of the extracts from fruits native to Brazil on metabolic parameters and hepatic oxidative markers in an animal model of insulin resistance induced by dexamethasone (DEX).

    Methods: Wistar rats received water or extracts of Eugenia uniflora or Psidium cattleianum, once a day for 21 days. Read More

    Increased Small Intestine Expression of non-Heme Iron Transporters in Morbidly Obese Patients With Newly Diagnosed Type 2 Diabetes.
    Mol Nutr Food Res 2017 Oct 29. Epub 2017 Oct 29.
    Department of Diabetes, Endocrinology and Nutrition, Institut d'Investigació Biomèdica de Girona (IdIBGi), CIBEROBN (CB06/03/010) and Instituto de Salud Carlos III (ISCIII), Girona, Spain.
    Scope: To investigate intestinal markers of iron absorption in morbidly obese subjects according to glucose tolerance.

    Methods And Results: Gene expression of both non-heme [SLC40A1 (ferroportin), SLC11A2] and heme iron [SLC46A1 (HCP1), HMOX1] transporters were analysed in 38 small intestine tissue samples [11 with normal glucose tolerance, 14 with glucose intolerance (GI) and 13 with newly diagnosed type 2 diabetes (T2D)]. SLC40A1 (r = 0. Read More

    Increased Serum ANGPTL8 Concentrations in Patients with Prediabetes and Type 2 Diabetes.
    J Diabetes Res 2017 7;2017:8293207. Epub 2017 Sep 7.
    Department of Endocrinology and Metabolism, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, 100 Haining Rd, Shanghai 200080, China.
    The objectives of the study were to investigate serum ANGPTL8 concentrations in different glucose metabolic statuses and to explore the correlations between serum ANGPTL8 levels and various metabolic parameters. Serum ANGPTL8 levels were determined using ELISA in 22 subjects with NGT (normal glucose tolerance), 74 subjects with IGR (impaired glucose regulation), and 33 subjects with T2DM (type 2 diabetes mellitus). Subjects with IFG, IGT, CGI, and T2DM had higher levels of serum ANGPTL8 than subjects with NGT. Read More

    Multi-System Deconditioning in 3-Day Dry Immersion without Daily Raise.
    Front Physiol 2017 13;8:799. Epub 2017 Oct 13.
    Centre de Recherche Clinique, Centre Hospitalier Universitaire d'Angers, Angers, France.
    Dry immersion (DI) is a Russian-developed, ground-based model to study the physiological effects of microgravity. It accurately reproduces environmental conditions of weightlessness, such as enhanced physical inactivity, suppression of hydrostatic pressure and supportlessness. We aimed to study the integrative physiological responses to a 3-day strict DI protocol in 12 healthy men, and to assess the extent of multi-system deconditioning. Read More

    Predicting persistent impaired glucose tolerance in GDM women: the role of hsCRP and adiponectin.
    Diabetes Metab Res Rev 2017 Oct 27. Epub 2017 Oct 27.
    Maternal Child Health Research Center, Department of Obstetrics and Gynecology.
    Background: To evaluate whether maternal serum adiponectin and high-sensitivity C-reactive protein (hsCRP) levels at the time of gestational diabetes (GDM) diagnosis are associated with persistent glucose intolerance in GDM women at 6-12 weeks postpartum.

    Methods: This is a secondary analysis of prospective randomized trial of GDM women enrolled in a behavior education program. Women with a GDM diagnosis ≥ 20 weeks were included. Read More

    A New Method for Targeted and Sustained Induction of Type 2 Diabetes in Rodents.
    Sci Rep 2017 Oct 26;7(1):14158. Epub 2017 Oct 26.
    School of Medicine, University of Tasmania, Hobart, Tasmania, Australia.
    Type 2 diabetes is a chronic metabolic disorder that is becoming a leading cause of morbidity and mortality. The prolonged time-course of human type 2 diabetes makes modelling of the disease difficult and additional animal models and methodologies are needed. The goal of this study was to develop and characterise a new method that allows controlled, targeted and sustained induction of discrete stages of type 2 diabetes in rodents. Read More

    Liver Reptin/RUVBL2 controls glucose and lipid metabolism with opposite actions on mTORC1 and mTORC2 signalling.
    Gut 2017 Oct 26. Epub 2017 Oct 26.
    INSERM, Bordeaux Research in Translational Oncology, Bordeaux, France.
    Objective: The AAA+ ATPase Reptin is overexpressed in hepatocellular carcinoma and preclinical studies indicate that it could be a relevant therapeutic target. However, its physiological and pathophysiological roles in vivo remain unknown. This study aimed to determine the role of Reptin in mammalian adult liver. Read More

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