5,536 results match your criteria Glottic Cancer


Retrospective analysis of 659 laryngeal squamous cell carcinoma patients treated with open laryngeal function-preserving operations.

Acta Otolaryngol 2018 Nov;138(11):1043-1050

a Department of Otolaryngology , Eye Ear Nose and Throat Hospital, Fudan University , Shanghai , China.

Background: Open laryngeal function-preserving surgery is a common therapeutic strategy for Chinese laryngeal squamous cell carcinoma (LSCC) patients.

Objectives: To explore the fundamental clinical characteristics and survival prognostic factors of LSCC patients treated with open laryngeal function-preserving operations.

Material And Methods: about a total of 659 LSCC patients undergoing open laryngeal function-preserving operations were retrospectively reviewed. Read More

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http://dx.doi.org/10.1080/00016489.2018.1500711DOI Listing
November 2018

Radiotherapy in advanced glottic laryngeal carcinoma in a patient with Wegener's granulomatosis: how much radiation dose is needed?

Onco Targets Ther 2019 23;12:753-757. Epub 2019 Jan 23.

Radiation Oncology Unit, San Giuseppe Moscati Hospital, Taranto, Italy,

Wegener's granulomatosis (WG) is an autoimmune disorder characterized by necrotizing granulomas involving mainly the upper-lower respiratory and renal tracts, albeit a potentially life-threatening involvement of other body parts is not rare. Furthermore, there are several reports accounting for an increased risk of solid malignancies due to the autoimmune disease per se, or the immunosuppressive therapies. Among treatments, radiotherapy could be a therapeutic option as proven by its use in typical WG lesions such as solitary granulomas or subglottic stenosis, successfully treated with low radiation dose. Read More

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http://dx.doi.org/10.2147/OTT.S182011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6352862PMC
January 2019

Factors responsible for the development of carbon granuloma post transoral laser cordectomy.

Lasers Med Sci 2019 Feb 13. Epub 2019 Feb 13.

Bombay Hospital Voice and Swallowing Centre, 2nd floor, MRC, Bombay Hospital & Medical Research Centre, 12 New Marine Lines, Mumbai, Maharashtra, 400020, India.

Our study was performed with an aim to analyse the factors responsible for the formation of a carbon granuloma (CG) following transoral laser microlaryngeal cordectomy (TLMC) for early glottic carcinoma. Our study comprises of retrospective data analysis of 78 patients who underwent TLMC for early glottic carcinoma between 2012 and 2017 with the laser settings of an acublade with scanning system, size 1-2 mm, depth 1-3 (250-750 μm), power 10 watts in a repeat mode with time off 0.25 s. Read More

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http://dx.doi.org/10.1007/s10103-019-02726-3DOI Listing
February 2019

Outcomes of carotid-sparing IMRT for T1 glottic cancer: Comparison with conventional radiation.

Laryngoscope 2019 Feb 12. Epub 2019 Feb 12.

Multidisciplinary Larynx Cancer Working Group from the Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, U.S.A.

Objectives: We aim to report oncologic outcomes after conventional radiotherapy (ConRT) using opposed lateral beams and intensity-modulated radiation therapy (IMRT) for tumor (T)1 nodal (N)0 T1 N0 glottic squamous cell carcinoma.

Study Design: Retrospective case-control study.

Methods: We retrospectively reviewed demographic, disease, and treatment characteristics for patients treated at our institution during 2000 to 2013. Read More

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http://dx.doi.org/10.1002/lary.27873DOI Listing
February 2019

Dysphagia optimized radiotherapy to reduce swallowing dysfunction severity in patients undergoing treatment for head and neck cancer: A systematized scoping review.

Head Neck 2019 Feb 5. Epub 2019 Feb 5.

Division of Speech Pathology, School of Health and Rehabilitation Sciences, The University of Queensland, St Lucia, Queensland, Australia.

This study involved a systematized scoping review to coalesce current evidence on dysphagia outcomes achieved through active sparing of the swallowing structures in patients receiving radiotherapy for head and neck cancer. Eligible publications between 2007 and 2017 were reviewed and synthesized regarding participant demographics, treatment regimens, swallowing structures chosen for optimization, dosimetric constraints, and dysphagia measures. Nine prospective cohort studies were included. Read More

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http://dx.doi.org/10.1002/hed.25688DOI Listing
February 2019
1 Read

Randomized controlled single-blinded clinical trial of functional voice outcome after vascular targeting KTP laser microsurgery of early laryngeal cancer.

Head Neck 2019 Jan 31. Epub 2019 Jan 31.

Department of Otorhinolaryngology-Section of Phoniatrics, Ludwig-Maximilians-University Medical Center, Munich, Germany.

Background: Local control rate (LCR) of early glottic cancer is high after radiation therapy or transoral laser microsurgery (TLM). The aim of this study was to investigate functional voice outcome after TLM using a microvessel-ablative potassium-titanyl-phosphate (KTP) laser in comparison with a gold standard cutting CO laser.

Methods: The primary end point of this prospective, randomized, single-blinded, clinical phase II study with control group was voice outcome during a follow-up of 6 months assayed by Voice Handicap Index (VHI-30)-questionnaires in patients with unilateral high-grade dysplasia, carcinoma in situ or early glottic cancer undergoing TLM-KTP (n = 8) or TLM-CO (n = 12). Read More

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http://dx.doi.org/10.1002/hed.25474DOI Listing
January 2019

Ultrasonography guided fine needle aspiration cytology in patients with laryngo-hypopharyngeal lesions.

Braz J Otorhinolaryngol 2018 Dec 28. Epub 2018 Dec 28.

All India Institute Of Medical sciences, Department of Otorhinolaryngology, New Delhi, India.

Introduction: Laryngeal lesions are usually evaluated by microlaryngoscopy/direct laryngoscopy under anaesthesia for disease mapping and tissue diagnosis. However patients with anticipated airway compromise due to laryngeal mass may require either a protective tracheotomy or emergency tracheotomy to secure the airway. To minimise risk of unplanned tracheotomy and expedite the diagnosis we performed ultrasound-guided transcutaneous fine needle aspiration cytology. Read More

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http://dx.doi.org/10.1016/j.bjorl.2018.11.005DOI Listing
December 2018
1 Read

Lower cranial nerve palsy during radiotherapy for glottic cancer in a patient with Wegener's granulomatosis: An interesting case report.

Mol Clin Oncol 2019 Jan 19;10(1):147-152. Epub 2018 Oct 19.

Department of Radiation Oncology, S. Giuseppe Moscati Hospital, I-74100 Taranto, Italy.

The aim of the present study was to report an unusual case of multiple lower cranial nerve palsies in a patient with Wegener's granulomatosis (WG) during radiotherapy for glottic cancer. WG is an autoimmune disease characterized by necrotizing granulomas mainly in the upper and lower respiratory tract or kidneys; however, the involvement of cranial nerves is not uncommon. Prior to the use of cyclophosphamide (CYC) the 1-year mortality rate was ~82%; the introduction of rituximab (RTX) has revolutionized the course of the WG, with remission rates comparable to those of CYC and superior effectiveness in relapsing patients. Read More

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http://dx.doi.org/10.3892/mco.2018.1748DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6315903PMC
January 2019
5 Reads

Voice outcome after unilateral ELS type III or bilateral type II resections for T1-T2 glottic carcinoma: Results after 1 year.

Head Neck 2019 Jan 16. Epub 2019 Jan 16.

Department of Otorhinolaryngology, Head & Neck Surgery, Leiden University Medical Center, Leiden, The Netherlands.

Background: Voice outcome was assessed in patients with extended T1 and limited T2 glottic carcinoma, treated with a unilateral type III or a bilateral type II resection according to the European Laryngological Society (ELS) classification.

Methods: Objective evaluation (acoustic and aerodynamic parameters), perceptual evaluation (GRBAS), and patients' self-assessment (voice handicap index [VHI]) were performed before and 1 year after treatment. Results were evaluated according to ELS resection type and the involvement of the anterior commissure. Read More

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http://dx.doi.org/10.1002/hed.25582DOI Listing
January 2019
2 Reads

Transoral laser microsurgery for glottic cancer in the elderly: Efficacy and safety.

Head Neck 2019 Jan 12. Epub 2019 Jan 12.

International Head and Neck Scientific Group, Padua, Italy.

Background: Data about the results of transoral laser microsurgery (TLM) in elderly patients are limited.

Methods: A retrospective study of 72 consecutive cases of glottic carcinoma (63 pT1 and 9 pT2 cases) in elderly patients (≥70 years old, mean 76 years) treated with TLM was made. A systematic review of the literature was performed. Read More

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http://dx.doi.org/10.1002/hed.25616DOI Listing
January 2019
6 Reads

Prediction of Posterior Paraglottic Space and Cricoarytenoid Unit Involvement in Endoscopically T3 Glottic Cancer with Arytenoid Fixation by Magnetic Resonance with Surface Coils.

Cancers (Basel) 2019 Jan 10;11(1). Epub 2019 Jan 10.

Department of Otorhinolaryngology, Maxillofacial, and Thyroid Surgery, Fondazione IRCCS, Istituto Nazionale dei Tumori di Milano, University of Milan, 20133 Milan, Italy.

Discrimination of the etiology of arytenoid fixation in cT3 laryngeal squamous cell carcinoma (SCC) is crucial for treatment planning. The aim of this retrospective study was to differentiate among possible causes of arytenoid fixation (edema, inflammation, mass effect, or tumor invasion) by analyzing related signal patterns of magnetic resonance (MR) in the posterior laryngeal compartment (PLC) and crico-arytenoid unit (CAU). Seventeen patients affected by cT3 glottic SCC with arytenoid fixation were preoperatively studied by state-of-the-art MR with surface coils. Read More

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http://dx.doi.org/10.3390/cancers11010067DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6356606PMC
January 2019
1 Read

Transoral laser microsurgery in early glottic cancer involving the anterior commissure.

Eur Arch Otorhinolaryngol 2019 Jan 2. Epub 2019 Jan 2.

Department of Otorhinolaryngology, Head and Neck Surgery, Ludwig-Maximilians-University Munich, Marchioninistr. 15, 81377, Munich, Germany.

Purpose: Treatment modalities for glottic cancer comprise surgery, (chemo-)radiation, and combined treatment options. Glottic cancer involving the anterior commissure (AC) requires special preoperative assessment and surgical skills, as it is commonly considered a risk factor for local recurrence. The aim of this study is to analyze the oncological effectiveness of transoral laser microsurgery (TLM) in the early glottic cancer involving the AC. Read More

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http://dx.doi.org/10.1007/s00405-018-5261-4DOI Listing
January 2019

Carcinoma Presenting as Idiopathic Anterior Glottic Webs: A Case Series.

Laryngoscope 2018 Dec 28. Epub 2018 Dec 28.

Columbia University Medical Center Department of Otolaryngology, New York, New York.

An anterior glottic web is an abnormal fusion of the anterior aspect of the membranous vocal folds. Noncongenital glottic webs are usually iatrogenic from intubation or laryngeal surgery. We present six adult patients whose initial in-office diagnoses were consistent with "idiopathic" benign anterior glottic webs as determined by three laryngologists (a. Read More

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http://doi.wiley.com/10.1002/lary.27711
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http://dx.doi.org/10.1002/lary.27711DOI Listing
December 2018
1 Read

Prognostic impact of initial treatment in surgically salvaged recurrences of early glottic cancer.

Laryngoscope 2018 Dec 18. Epub 2018 Dec 18.

Department of Otorhinolaryngology, Careggi University Hospital, Florence, Italy.

Objective: The purpose of this study was to analyze the outcomes of surgically salvaged early glottic cancer (EGC) recurrences after initial radiotherapy (RT) or transoral laser microsurgery (TLM).

Methods: A matched pair analysis by recurrent tumor-node-metastasis stage (rTNM) considering 27 patients who had TLM as initial treatment and 54 patients who failed after primary RT was performed. Post-recurrence overall and disease-specific survival (DSS) were evaluated. Read More

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http://dx.doi.org/10.1002/lary.27702DOI Listing
December 2018
2 Reads

Molecular and immunologic analysis of laryngeal squamous cell carcinoma in smokers and non-smokers.

Am J Otolaryngol 2018 Nov 22. Epub 2018 Nov 22.

Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins Hospital, Baltimore, MD, USA.

Background: Laryngeal squamous cell carcinoma (LSCC) is strongly associated with tobacco use, but recent reports suggest an increasing incidence of LSCC in patients without traditional risk factors, suggesting an alternative etiology of tumorigenesis. The purpose of this study is to characterize this non-smoking population and to compare immunohistochemical markers in tumor specimens from non-smokers and smokers with LSCC.

Methods: A retrospective chart review of patients with LSCC at Johns Hopkins Hospital (JHH) was performed. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01960709183088
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http://dx.doi.org/10.1016/j.amjoto.2018.11.009DOI Listing
November 2018
4 Reads

Long-term changes in vocal function after supracricoid partial laryngectomy with cricohyoidoepiglottopexy for laryngeal cancer.

Head Neck 2019 Jan 12;41(1):139-145. Epub 2018 Dec 12.

Department of Otolaryngology-Head and Neck Surgery, Graduate School of Medicine, Kumamoto University, Kumamoto, Japan.

Background: The purpose of this study was to assess changes in vocal function over time following supracricoid partial laryngectomy with cricohyoidoepiglottopexy (SCL-CHEP).

Methods: A total of 17 patients who underwent SCL-CHEP for laryngeal squamous cell carcinoma between 2007 and 2015 were reviewed. We examined maximum phonation time (MPT), mean airflow rate (MFR), voice intensity, the grade, roughness, breathiness, asthenia, and strain (GRBAS) scale, Voice Handicap Index-10 (VHI-10), and voice-related quality of life (V-RQOL) scores. Read More

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http://dx.doi.org/10.1002/hed.25487DOI Listing
January 2019

Phonosurgical Resection Using Submucosal Infusion Technique for Early Glottic Lesions: Diagnostic and Therapeutic Procedure?

Ann Otol Rhinol Laryngol 2018 Dec 14:3489418819544. Epub 2018 Dec 14.

1 Clinic of Otolaryngology, Head and Neck Surgery, Department of Translational Surgery and Medicine, Careggi University Hospital, Florence, Italy.

Objectives:: The aim of this study was to assess the feasibility of the submucosal infusion combined with microflap dissection via laser CO2 as both a diagnostic and therapeutic procedure for superficial glottic lesions. To define a safe surgical procedure in terms of local control, a morphometric study of surgical margins was performed.

Methods:: From January 2011 to January 2016, we treated 122 patients with early glottic lesions with phonomicrosurgery. Read More

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http://dx.doi.org/10.1177/0003489418819544DOI Listing
December 2018
1 Read

Efficacy of laser surgery versus radiotherapy for treatment of glottic carcinoma: a systematic review and meta-analysis.

Lasers Med Sci 2018 Dec 6. Epub 2018 Dec 6.

Nursing College of Shanxi Medical University, Taiyuan, 030001, Shanxi, People's Republic of China.

Laser surgery and radiotherapy are the two most common ways to treat glottic carcinomas, which is more efficacious and remains controversial. PubMed, Embase, and Cochrane Library were searched to identify relevant studies of laser surgery versus radiotherapy in patients with glottic carcinomas through April 2017. Sensitivity analysis and subgroup analysis were performed to evaluate heterogeneity. Read More

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http://dx.doi.org/10.1007/s10103-018-2695-2DOI Listing
December 2018
1 Read

Completion Total Laryngectomy Ten Years After Near Total Laryngectomy for Radiorecurrent Cancer of the Glottis.

Indian J Surg Oncol 2018 Dec 9;9(4):605-608. Epub 2018 Aug 9.

Division of Surgical Oncology (Head and Neck Services), Regional Cancer Centre, Trivandrum, Kerala 695011 India.

Near total laryngectomy (NTL) is a safe alternative to total laryngectomy in salvaging lateralized radiation failures. A 65-year-old gentleman with radiorecurrent T1 vocal cord cancer was salvaged successfully by NTL. Ten years later, he presented with a strained shunt speech which was treated judiciously, with the aid of a positron emission tomography (PET) scan, by a (completion) total laryngectomy (TL), bilateral selective neck dissection, and pharyngeal resurfacing with pectoralis major myocutaneous (PMMC) flap. Read More

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http://dx.doi.org/10.1007/s13193-018-0795-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6265171PMC
December 2018
1 Read

Symmetrical Apophyses on the Posterior Margins of the Thyroid Cartilage: A Previously Undescribed Anatomical Variation With Potential Forensic Implications.

Am J Forensic Med Pathol 2019 Mar;40(1):84-88

Departamento de Anatomía y Embriología Humana Facultad de Medicina, Universidad Complutense de Madrid, Madrid, Spain.

Differential diagnosis between normal/variant anatomy and pathological/traumatic findings represents one of the main matters of investigation of the so-called forensic clinical anatomy. In the literature, many anatomical variations of the laryngeal thyroid cartilage have been reported, with potential implications in forensic pathology. They include triticeal cartilages, foramen thyroideum, asymmetry, segmentation or agenesis of the superior thyroid horns, bone connections with the hyoid bone, absence of cricothyroid facets, hypertrophy of the inferior thyroid tubercle, and asymmetries in the thyroid notch, isthmus, or length of the inferior horn. Read More

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http://Insights.ovid.com/crossref?an=00000433-900000000-9917
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http://dx.doi.org/10.1097/PAF.0000000000000452DOI Listing
March 2019
3 Reads

Treatment of early-stage laryngeal cancer: A comparison of treatment options.

Oral Oncol 2018 Dec 16;87:8-16. Epub 2018 Oct 16.

Stanford University School of Medicine, Department of Otolaryngology Head and Neck Surgery, USA.

Over the course of the last several decades, the treatment options for early laryngeal cancers (T1 and T2) have evolved; however, simultaneously the mortality rate has increased. As larynx preservation approaches have become the standard of care, the selection of the proper treatment modality has become paramount. Radiation therapy or transoral laser microsurgery are the most common options for treatment of these early lesions. Read More

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http://dx.doi.org/10.1016/j.oraloncology.2018.09.012DOI Listing
December 2018
2 Reads

Outcomes of Treating Early Glottic Neoplasms With a Potassium Titanyl Phosphate Laser.

Ann Otol Rhinol Laryngol 2019 Feb 11;128(2):85-95. Epub 2018 Dec 11.

2 Auckland City Hospital, Auckland, New Zealand.

Objectives:: The aim of this study was to assess the outcome of treating glottic dysplasia and early squamous cell carcinoma (SCC) with potassium titanyl phosphate (KTP) photoangiolytic laser ablation.

Methods:: Patient demographics, comorbidities, and tumor characteristics were recorded. Perceptual, patient-reported, and objective voice outcomes were assessed. Read More

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http://dx.doi.org/10.1177/0003489418806914DOI Listing
February 2019
5 Reads

Carbon Dioxide Laser Microsurgery versus Low-Temperature Plasma Radiofrequency Ablation for T1a Glottic Cancer: A Single-Blind Randomized Clinical Trial.

Biomed Res Int 2018 1;2018:4295960. Epub 2018 Nov 1.

Department of Otolaryngology, The Third Hospital of Wuhan City, Wuhan, Hubei Province, China.

Background: Very few studies have been conducted to compare carbon dioxide laser microsurgery (CO2-LS) with low-temperature plasma radiofrequency ablation (LTP-RFA) in treating T1a glottic cancer. Therefore, we conducted this study to compare the efficacy of CO2-LS and LTP-RFA to define a superior therapeutic modality for T1a glottic cancer.

Methods: Patients (n=131) with T1a glottic cancer were recruited between January 2010 and September 2014. Read More

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http://dx.doi.org/10.1155/2018/4295960DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6241367PMC
November 2018
1 Read

Impact of the anterior commissure involvement on the survival of early glottic cancer treated with cricohyoidoepiglottopexy: a retrospective study.

Cancer Manag Res 2018 8;10:5553-5558. Epub 2018 Nov 8.

Otolaryngology, Department of Health Sciences, University of Catanzaro, Catanzaro, Italy,

Background: Laryngeal early glottic tumors can benefit from different treatment modalities, including transoral laser microsurgery, open partial horizontal laryngectomy (OPHL), and radiotherapy. However, the treatment of early glottic tumors with the involvement of the anterior commissure remains controversial. The studies about the role of anterior commissure involvement in oncologic outcomes in patients with early glottic cancer treated with supracricoid laryngectomy (SCL) are very few. Read More

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http://dx.doi.org/10.2147/CMAR.S182854DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6234988PMC
November 2018
2 Reads

Omitting the lower neck and sparing the glottic larynx in node-negative nasopharyngeal carcinoma was safe and feasible, and improved patient-reported voice outcomes.

Clin Transl Oncol 2018 Dec 4. Epub 2018 Dec 4.

Department of Oral and Maxillofacial-Head Neck Oncology, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, 639 Zhizaoju Road, Shanghai, 200011, People's Republic of China.

Background: Worsening voice and speech quality was frequently reported in head-and-neck patients after radiotherapy to the neck; omitting the lower neck and sparing the glottic larynx in node-negative nasopharyngeal carcinoma (NPC) patients might be safe and feasible, and improve voice and speech outcomes.

Methods: From January 2009 to January 2013, 71 patients were analyzed. All patients received bilateral neck irradiation. Read More

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http://dx.doi.org/10.1007/s12094-018-1988-zDOI Listing
December 2018
9 Reads

Long Term Oncological Results of Transoral Laser Microsurgery for Early and Moderately Advanced Glottic Carcinoma in Primary and Salvage Settings.

Indian J Otolaryngol Head Neck Surg 2018 Dec 29;70(4):463-470. Epub 2018 Sep 29.

1Department of Otolaryngology and Head & Neck Surgery, All India Institute of Medical Sciences, New Delhi, 110029 India.

The aim of the study is to document the long term oncological results of trans-oral laser microsurgery (TLM) for early and moderately advanced glottic cancer in primary and salvage settings. In this prospective cohort study 43 consecutive patients of glottic cancer (T1-30, T2-7, and selected T3 with mobile cords-6) were recruited. TLM was performed in these 35 primary and 8 previously treated cases. Read More

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http://dx.doi.org/10.1007/s12070-018-1505-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6224817PMC
December 2018
8 Reads

[Impact of Respiratory Motion on Dose Variation in Radiation Therapy for Glottic Cancer].

Nihon Hoshasen Gijutsu Gakkai Zasshi 2018;74(11):1269-1274

Department of Radiation Therapy, Cancer Institute Hospital.

In radiation therapy for glottic cancer, respiratory motion of larynx may change the dose variation in the target. The purpose of this study is to measure the respiratory motion of the larynx, and quantify the impact of the motion on the dose variation. This study included 10 patients treated by opposing portal irradiation for glottic cancer. Read More

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http://dx.doi.org/10.6009/jjrt.2018_JSRT_74.11.1269DOI Listing
January 2018
7 Reads

Narrow band imaging in transoral laser microsurgery (TLM) in moderately advanced (T2, T3) glottic cancer.

Otolaryngol Pol 2018 Aug;72(5):17-23

Department of Otolaryngology, Head and Neck Surgery, Poznań University of Medical Sciences, Poznań, Poland.

Introduction: Treatment planning in T2, T3 laryngeal carcinoma is based on clinical assessment and radiological imaging. However, to delineate precise mucosal margins for transoral laser microsurgery (TLM), a high class, sophisticated endoscopy is indispensable. Narrowband imaging (NBI) which is an optical filter technology, seems to be a useful adjunctive tool in marking superficial margins. Read More

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http://dx.doi.org/10.5604/01.3001.0012.0486DOI Listing
August 2018
14 Reads

Immunohistochemical analysis of vocal cord polyps applying markers of squamous cell carcinogenesis.

Pathol Res Pract 2019 Jan 10;215(1):144-150. Epub 2018 Nov 10.

Faculty of Medicine, University of Rijeka, Rijeka, Croatia.

Objective: The aim of the study was to perform a pathohistological and immunohistochemical analysis of squamous cell (SC) carcinogenesis markers on epithelial linings of vocal cord polyps. The vocal box, being a heavily burdened organ with intensive cell renewal and regenerative processes, is therefore a favourable environment for constant epithelial growth and hyperplasia. In our ongoing projects on laryngeal carcinogenesis and research on laryngeal tissue, we encountered atypia on diagnosed nodules and polyps that are usually considered as benign formations, resulting from the above-mentioned cell renewal and regeneration, which lead to further investigation. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03440338183131
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http://dx.doi.org/10.1016/j.prp.2018.11.001DOI Listing
January 2019
11 Reads

Glottic exposure for transoral laser microsurgery: Proposal of a mini-version of the laryngoscore.

Laryngoscope 2018 Nov 8. Epub 2018 Nov 8.

Department of Otorhinolaryngology-Head and Neck Surgery, University of Genoa, Genoa, Italy.

Objectives: Good laryngeal exposure (GLE) is typically regarded as an essential prerequisite for transoral laser microsurgery (TLM). The Laryngoscore is a preoperative scoring system aimed at predicting glottic visualization through the laryngoscope using easy patient-derived parameters. However, the presence of subjective variables may hamper its reliability and reproducibility. Read More

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http://doi.wiley.com/10.1002/lary.27525
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http://dx.doi.org/10.1002/lary.27525DOI Listing
November 2018
10 Reads

[The morphplogical and its influencing factors research after supracricoid partial laryngectory with cricohyoidoepiglottopexy].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Oct;32(20):1584-1587

Department of Otolaryngology Head and Neck Surgery, the First Affiliated Hospital of Guangxi Medical University, Nanning, 530021, China.

The aim of this study for observing laryngeal morphology, and motion characteristics after supracricoid partial laryngectomy with cricohyoidoepiglottopexy(SCPL-CHEP),exploring the relevant factors affecting the morphology of new laryngeal. Choose 46 cases of patients with laryngeal cancer for SCPL-CHEP as the object of study, dynamic laryngoscope were performed in all the patients, to observe the movement of laryngeal pronunciation (neoglottis closure , supraglottic situation) . Combined with the patient's clinical data, the relevant factors that may affect the pronunciation and movement characteristics of the new throat were analyzed. Read More

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http://www.cnki.net/kcms/doi/10.13201/j.issn.1001-1781.2018.
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http://dx.doi.org/10.13201/j.issn.1001-1781.2018.20.012DOI Listing
October 2018
6 Reads

Low expression of pRB predicts disease relapse in early glottic cancer treated with transoral laser microsurgery.

Laryngoscope 2018 Nov 1. Epub 2018 Nov 1.

Department of Nuclear Medicine and Molecular Imaging Center, Linkou-Chang Gung Memorial Hospital, Chang Gung University, Taoyuan, Taiwan.

Objectives/hypothesis: To elucidate the associations among the immunohistochemical expression of tumor markers, clinicopathological variables, and disease-free survival (DFS) in patients with early-stage glottic squamous cell carcinoma (SCC) who underwent transoral laser microsurgery (TLM) as the primary treatment.

Study Design: Retrospective chart review.

Methods: The records of consecutive patients with Tis-T2N0 glottic SCC who underwent TLM between August 1, 2012 and October 31, 2015 were reviewed. Read More

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http://doi.wiley.com/10.1002/lary.27612
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http://dx.doi.org/10.1002/lary.27612DOI Listing
November 2018
2 Reads

Evaluation of upper esophageal sphincter in benign vocal lesions.

Eur Arch Otorhinolaryngol 2018 Dec 22;275(12):3033-3037. Epub 2018 Oct 22.

Department of Otolaryngology, Selcuk University Medical School, Alaeddin Keykubad Campus, 42075 Yeni Istanbul caddesi, Konya, Turkey.

Purpose: To evaluate upper esophageal sphincter (UES) activity in patients with benign glottic lesions.

Methods: Twenty-three patients with benign vocal fold (VF) lesions scheduled for manometric evaluation were enrolled as the study group (SG); 20 healthy subjects without vocal pathology or dysphagia were included as the control group (CG). UES residual, basal, relaxation time and peak pharyngeal pressures were evaluated by manometry. Read More

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http://link.springer.com/10.1007/s00405-018-5175-1
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http://dx.doi.org/10.1007/s00405-018-5175-1DOI Listing
December 2018
10 Reads

Radiation-Associated Chronic Dysphagia Assessment by Flexible Endoscopic Evaluation of Swallowing (FEES) in Head and Neck Cancer Patients: Swallowing-Related Structures and Radiation Dose-Volume Effect.

Ann Otol Rhinol Laryngol 2019 Feb 20;128(2):73-84. Epub 2018 Oct 20.

1 Faculty of Medicine, Department of Radiation Oncology, Ege University, Ankara Street, Izmir, Turkey.

Purpose: We aimed to restore dose-volume parameters of swallowing-related structures (SRSs) by evaluating long-term swallowing dysfunctions after radiotherapy (RT) in head and neck cancer patients (HNCPs).

Materials And Methods: Head and neck cancer patients whose pharyngeal region was involved in RT portal and treated with definitive RT/chemoradiotherapy (CRT) were included in the analyses. Patients underwent objective swallowing assessment by flexible endoscopic evaluation of swallowing (FEES). Read More

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http://dx.doi.org/10.1177/0003489418804260DOI Listing
February 2019
17 Reads

[Clinical analysis of malignant salivary gland tumors of the larynx].

Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Sep;53(9):684-687

Department of Otorhinolaryngology, Eye Ear Nose and Throat Hospital of Fudan University, Shanghai 200031, China.

To evaluate the clinical features, treatments and prognoses of malignant salivary gland tumors of the larynx. A total of 14 patients with malignant salivary gland tumors of the larynx diagnosed and treated in our hospital between 2003 and 2014 were analyzed retrospectively, and were compared with 62 patients from the Surveillance, Epidemiology, and End (SEER) database of American for survival rates. Results Among 14 patients from our hospital, 9 males and 5 females, with a median of 66. Read More

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http://dx.doi.org/10.3760/cma.j.issn.1673-0860.2018.09.009DOI Listing
September 2018
15 Reads

International neuromonitoring study group guidelines 2018: Part II: Optimal recurrent laryngeal nerve management for invasive thyroid cancer-incorporation of surgical, laryngeal, and neural electrophysiologic data.

Laryngoscope 2018 Oct 6;128 Suppl 3:S18-S27. Epub 2018 Oct 6.

Department of Otolaryngology, Division of Thyroid and Parathyroid Surgery, Massachusetts Eye and Ear, Harvard Medical School, Boston, Massachusetts, U.S.A.

The purpose of this publication was to inform surgeons as to the modern state-of-the-art evidence-based guidelines for management of the recurrent laryngeal nerve invaded by malignancy through blending the domains of 1) surgical intraoperative information, 2) preoperative glottic function, and 3) intraoperative real-time electrophysiologic information. These guidelines generated by the International Neural Monitoring Study Group (INMSG) are envisioned to assist the clinical decision-making process involved in recurrent laryngeal nerve management during thyroid surgery by incorporating the important information domains of not only gross surgical findings but also intraoperative recurrent laryngeal nerve functional status and preoperative laryngoscopy findings. These guidelines are presented mainly through algorithmic workflow diagrams for convenience and the ease of application. Read More

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http://doi.wiley.com/10.1002/lary.27360
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http://dx.doi.org/10.1002/lary.27360DOI Listing
October 2018
15 Reads
2.032 Impact Factor

Airway Management During Anesthetic Induction of Secondary Laryngectomy for Recurrent Laryngeal Cancer: Three Cases of Report and Analysis.

Front Med (Lausanne) 2018 19;5:264. Epub 2018 Sep 19.

Department of Anesthesiology, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.

Surgery for laryngeal cancer and the following recurrent tumor growth may further change the anatomy of the airway. Airway management during anesthesia induction is challenging for the patients undergoing secondary surgery due to recurrence of laryngeal cancer or its postoperative complication, but it has never been reported. In this report, we described three cases of anesthetic induction which had different process of airway events. Read More

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https://www.frontiersin.org/article/10.3389/fmed.2018.00264/
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http://dx.doi.org/10.3389/fmed.2018.00264DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6157329PMC
September 2018
4 Reads

[Advances in the treatment of anterior commissure combined with early glottic carcinoma].

Authors:
Y Y Tang B P Miao

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Aug;32(16):1280-1283

Early glottic laryngeal cancer usually refers to the Tis-T2 lesion without cervical lymph node and distant metastases. Radiotherapy of early glottic laryngeal cancer, CO₂ laser microsurgery, open surgery, plasma radiofrequency ablation, photodynamic therapy, biological targeting therapy have achieved good therapeutic effect. However, due to the special nature of its anatomy, it is controversial about the treatment of early glottic laryngeal cancer which involves the anterior commissure. Read More

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http://www.cnki.net/kcms/doi/10.13201/j.issn.1001-1781.2018.
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http://dx.doi.org/10.13201/j.issn.1001-1781.2018.16.018DOI Listing
August 2018
1 Read

Surgical Treatment Modalities for Iatrogenic Anterior Glottic Stenosis.

Ann Otol Rhinol Laryngol 2018 Dec 29;127(12):946-952. Epub 2018 Sep 29.

1 Department of Otorhinolaryngology-Head and Neck Surgery, Huashan Hospital, Fudan University, Shanghai, China.

Objectives:: The aim of this study was to describe common iatrogenic causes of anterior glottic stenosis and to investigate the surgical treatment outcomes of 3 different techniques aimed at repairing stenoses and preventing web reformation.

Methods:: Clinical information regarding patient demographics, presentation, etiology, treatment, and follow-up outcomes was obtained retrospectively through a review of patients' records between April 2010 and April 2017. Voice quality was evaluated using grade, roughness, breathiness, asthenia, and strain scale and Voice Handicap Index scores. Read More

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http://journals.sagepub.com/doi/10.1177/0003489418803651
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http://dx.doi.org/10.1177/0003489418803651DOI Listing
December 2018
5 Reads

A comparison of phonatory outcome between trans-oral CO Laser cordectomy and radiotherapy in T1 glottic cancer.

Eur Arch Otorhinolaryngol 2018 Nov 29;275(11):2783-2786. Epub 2018 Sep 29.

Voice Clinic, Deenanath Mangeshkar Hospital, Pune, India.

Purpose: This study aimed at comparing phonatory outcomes between Trans-oral Laser Surgery and Radiotherapy in T1 glottic cancer.

Introduction: Early glottic carcinoma, i.e. Read More

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http://dx.doi.org/10.1007/s00405-018-5152-8DOI Listing
November 2018

Identity and novelty in the avian syrinx.

Proc Natl Acad Sci U S A 2018 10 24;115(41):10209-10217. Epub 2018 Sep 24.

Department of Geological Sciences, University of Texas at Austin, Austin, TX 78712

In its most basic conception, a novelty is simply something new. However, when many previously proposed evolutionary novelties have been illuminated by genetic, developmental, and fossil data, they have refined and narrowed our concept of biological "newness." For example, they show that these novelties can occur at one or multiple levels of biological organization. Read More

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http://dx.doi.org/10.1073/pnas.1804586115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6187200PMC
October 2018
9.810 Impact Factor

CO Transoral Microsurgery for Supraglottic Squamous Cell Carcinoma.

Front Oncol 2018 4;8:321. Epub 2018 Sep 4.

Unit of Otorhinolaryngology, Department of Surgery, Azienda Ospedaliero-Universitaria di Cagliari, University of Cagliari, Cagliari, Italy.

The present study analyzed the results of the endoscopic approach to T1, T2 and selected T3 supraglottic carcinoma with the aim of reviewing functional and oncologic outcomes after different types of endoscopic supraglottic laryngectomies. This is a retrospective clinical study of 42 consecutive patients (mean age of 61.8 years, 33 males, 9 females) treated by the senior author for supraglottic squamous cell carcinoma with a transoral CO laser approach and reviewed from November 2010 to September 2017. Read More

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http://dx.doi.org/10.3389/fonc.2018.00321DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6131582PMC
September 2018
7 Reads

One-lung ventilation in a patient with a large mass on the glottis: A case report.

Medicine (Baltimore) 2018 Sep;97(36):e12237

Rationale: One-lung ventilation (OLV) is required during most thoracic surgeries to facilitate surgical visualization by collapsing the lung. Double-lumen tubes and bronchial blockers are two commonly used devices for OLV; however, it may be difficult to place two devices in patients with narrow inlets, such as those that have tumor-induced airway stenosis.

Patient Concerns: We report the case of an adult patient with a lung tumor that was growing rapidly and hemorrhaging; thus, a thoracotomy for lung resection should have been performed as early as possible. Read More

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http://dx.doi.org/10.1097/MD.0000000000012237DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6133415PMC
September 2018

Is There a Change in the Treatment of T1 Glottic Cancer After CO Laser? A Comparative Study with Cold Steel.

Turk Arch Otorhinolaryngol 2018 Jun 1;56(2):64-69. Epub 2018 Jun 1.

Department of Otorhinolaryngology, Uludağ University School of Medicine, Bursa, Turkey.

Objective: Carbon dioxide (CO) laser provides high local control and disease-specific survival rates with minor morbidity and good quality of life in transoral cordectomy. We aimed to compare the oncological outcome and survival between cold steel and CO laser in the treatment of early glottic cancer.

Methods: In this retrospective study, the participants were divided into two groups. Read More

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http://dx.doi.org/10.5152/tao.2018.3053DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6123107PMC
June 2018
1 Read

The correlation of prognostic biomarkers (Ki-67, Bcl-2, HIF-1α, cyclin D1) with metabolic tumor volume measured by F-FDG PET/CT inlaryngeal cancer.

J Cancer Res Ther 2018 Jul-Sep;14(5):994-998

Department of Nuclear Medicine, Faculty of Medicine, Adnan Menderes University, Aydin, Turkey.

Objectives: To investigate the correlation between tumor stage, Ki-67, Bcl-2, hypoxia inducible factor-1α (HIF-1α), cyclin D1 and metabolic tumor volume (MTV), total lesion glycolysis (TLG), maximum standardized uptake value (SUV) measured by F fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT) in patients diagnosed with laryngeal cancer.

Patients And Methods: In this study, included 25 consecutive laryngeal cancer patients (2 women, 23 men) diagnosed and treated in the Otorhinolaryngology Department of our tertiary care center. All cases underwent F FDG PET/CT and SUV, mean standardized uptake value, MTV, and TLG values were calculated. Read More

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http://dx.doi.org/10.4103/0973-1482.179162DOI Listing
November 2018
1 Read

Wound healing after transoral angiolytic laser surgery for early glottic carcinoma.

Laryngoscope 2019 Feb 8;129(2):435-440. Epub 2018 Sep 8.

Department of Surgery, Harvard Medical School, Center for Laryngeal Surgery and Voice Rehabilitation, Massachusetts General Hospital, Boston, Massachusetts, U.S.A.

Objectives/hypothesis: Wound healing after transoral angiolytic laser surgery for early glottic carcinoma was analyzed to identify factors influencing healing and clinical significance of persistent granulation tissue.

Study Design: Retrospective review.

Methods: A retrospective review of 100 consecutive patients undergoing endoscopic angiolytic laser surgery for T1 and T2 glottic carcinoma was performed. Read More

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http://doi.wiley.com/10.1002/lary.27283
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http://dx.doi.org/10.1002/lary.27283DOI Listing
February 2019
13 Reads

Does Reinke's Edema Grade Determine Premalignant Potential?

Ann Otol Rhinol Laryngol 2018 Nov 6;127(11):812-816. Epub 2018 Sep 6.

3 Department of Otolaryngology, Montefiore Medical Center, Bronx, New York, USA.

Objective: Reinke's edema (RE) is a benign disease of the vocal folds with a wide spectrum of clinical severity. We aim to evaluate the clinical impact of RE grade and determine if RE grade correlates with severity of dysplasia and tobacco exposure.

Methods: Patients with isolated RE who underwent surgical excision between December 2010 and December 2014 were retrospectively reviewed. Read More

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http://dx.doi.org/10.1177/0003489418796529DOI Listing
November 2018
13 Reads

Immediate selective laryngeal reinnervation in vagal paraganglioma patients.

J Laryngol Otol 2018 Sep 5;132(9):846-851. Epub 2018 Sep 5.

Royal National Throat,Nose and Ear Hospital,University College London Hospital NHS Trust,UK.

Objective: This prospective case series aimed to present the outcomes of immediate selective laryngeal reinnervation.

Methods: Two middle-aged women with vagal paraganglioma undergoing an excision operation underwent immediate selective laryngeal reinnervation using the phrenic nerve and ansa cervicalis as the donor nerve. Multidimensional outcome measures were employed pre-operatively, and at 1, 6 and 12 months post-operatively. Read More

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http://dx.doi.org/10.1017/S0022215118000476DOI Listing
September 2018
11 Reads

Functional identification of abductor and adductor branches for laryngeal transplantation.

Eur Arch Otorhinolaryngol 2018 Nov 1;275(11):2813-2816. Epub 2018 Sep 1.

Department of Otorhinolaryngology, Faculty of Medicine and Dentistry, Medical University of Warsaw, 19/25 Stepinska Street, 00-739, Warsaw, Poland.

Purpose: This is a feasibility study of functional identification of the abductor and adductor recurrent laryngeal nerve branches, which could be used in the donor's larynx for functional laryngeal transplantation.

Methods: The study was performed on swine (n = 3) and human (n = 4) models of a donor larynx. The recurrent laryngeal nerve and its branches were found. Read More

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http://dx.doi.org/10.1007/s00405-018-5112-3DOI Listing
November 2018
2 Reads

Effect of a Strategy of a Supraglottic Airway Device vs Tracheal Intubation During Out-of-Hospital Cardiac Arrest on Functional Outcome: The AIRWAYS-2 Randomized Clinical Trial.

JAMA 2018 08;320(8):779-791

Clinical Trials and Evaluation Unit, Bristol Trials Centre, Bristol Medical School, University of Bristol, Bristol, England.

Importance: The optimal approach to airway management during out-of-hospital cardiac arrest is unknown.

Objective: To determine whether a supraglottic airway device (SGA) is superior to tracheal intubation (TI) as the initial advanced airway management strategy in adults with nontraumatic out-of-hospital cardiac arrest.

Design, Setting, And Participants: Multicenter, cluster randomized clinical trial of paramedics from 4 ambulance services in England responding to emergencies for approximately 21 million people. Read More

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http://dx.doi.org/10.1001/jama.2018.11597DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6142999PMC
August 2018
46 Reads