5,942 results match your criteria Glottic Cancer


Glottic Malignant Fibrous Histiocytoma: A Case Report and Literature Review.

Case Rep Oncol 2021 Jan-Apr;14(1):641-646. Epub 2021 Mar 31.

Hazm Mebaireek General Hospital (HMGH), Hamad Medical Corporation (HMC), Doha, Qatar.

Pleomorphic sarcoma of the larynx is a rare variant of laryngeal cancer. We present the case of a 59-year-old male patient who has been smoking for 40 years. He presented with signs and symptoms of an obstructive glottic mass. Read More

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Management of Early Glottic Cancer Treated by CO2 Laser According to Surgical-Margin Status: A Systematic Review of the Literature.

Int Arch Otorhinolaryngol 2021 Apr 24;25(2):e301-e308. Epub 2020 Sep 24.

Department of Biomedicine, Neuroscience and Advanced Diagnostics, ENT Clinic, University of Palermo, Palermo, Italy.

 Transoral laser microsurgery (TLM) is the treatment of choice for Tis-T2 squamous cell glottic carcinomas due to its advantages compared with open surgery and radiotherapy. However, the CO laser beam causes changes and damage on the specimens, making the histological assessment of resection margins, the gold standard for confirming radical tumor resection, sometimes difficult.  To assess the different ways to manage patients depending on the status of the histopathological margin according to recent studies to detect the most commonly shared therapeutic strategy. Read More

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Exploring the Interplay Between Radiotherapy Dose and Physiological Changes in the Swallowing Mechanism in Patients Undergoing (Chemo)radiotherapy for Oropharynx Cancer.

Dysphagia 2021 May 8. Epub 2021 May 8.

Radiation Oncology Department, Princess Alexandra Hospital, Ipswich Road, Brisbane, QLD, 4102, Australia.

This study explored associative relationships between radiotherapy dose volumes delivered to the dysphagia aspiration risk structures (DARS) and swallowing physiological disturbance at 3 months post treatment in a homogenous cohort of patients who received (chemo)radiotherapy ((C)RT) for oropharyngeal head and neck cancer (HNC). Participants(n = 53) were a subgroup of patients previously recruited as part of a prospective randomised trial, and had undergone physiological swallowing assessment using videofluroscopic swallowing study (VFSS) at 3 months post (C)RT. The extended oral cavity (EOC), supraglottic larynx (SGL), glottic larynx (GL), cricopharyngeal inlet (CI), and pharyngeal constrictor muscles (PCM) were contoured as per international consensus guidelines and dose volume histograms (DVHs) were generated for each structure. Read More

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APE1 facilitates PD-L1-mediated progression of laryngeal and hypopharyngeal squamous cell carcinoma.

Int Immunopharmacol 2021 May 6;97:107675. Epub 2021 May 6.

Department of Otolaryngology Head and Neck Surgery, Shengjing Hospital of China Medical University, Shenyang 110004, Liaoning, China. Electronic address:

Laryngeal squamous cell carcinoma (LSCC) and hypopharyngeal squamous cell carcinoma (HSCC) seriously affect the life quality of patients. Nowadays, immunotherapy is widely used in the treatment of cancer. Tumor-infiltrating lymphocytes (TILs), programmed cell death 1 (PD-1) and its ligand programmed cell death ligand 1 (PD-L1) play key roles in the immunotherapy of cancer. Read More

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Near-complete glottic obstruction from a loose glottic cancer mass.

Can J Anaesth 2021 May 4. Epub 2021 May 4.

Department of Anesthesiology, Pain Management, and Perioperative Medicine, Dalhousie University, Halifax, NS, Canada.

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I seed implantation brachytherapy for glottic carcinoma: an experimental and clinical study.

Am J Cancer Res 2021 15;11(4):1321-1334. Epub 2021 Apr 15.

Department of Interventional Radiology, The First Affiliated Hospital of Zhengzhou University Zhengzhou, China.

I seed implantation brachytherapy (ISIB) is the preferred treatment for prostate cancer. Is ISIB technically suitable for glottic carcinoma (GC)? This question has not been answered in the literature; thus, the present study was carried out to evaluate the feasibility and effect of ISIB on GC in animal and clinical studies. An animal model of Tu-212 cell laryngeal carcinoma xenografts (n = 20 animals) underwent ISIB treatments [experimental group (EG) using 0. Read More

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[Radiotherapy for patients with early-stage glottic squamous cell carcinoma of the larynx: Interest of hypofractionation?]

Cancer Radiother 2021 Apr 27. Epub 2021 Apr 27.

Département universitaire de radiothérapie, centre Oscar-Lambret, 3, rue Frédéric-Combemale, 59000 Lille, France. Electronic address:

Hypofractionated radiotherapy of early-stage squamous cell carcinoma of the glottic larynx is a promising treatment option. This can be divided into radiotherapy with moderate hypofractionation (up to 2.5Gy per fraction), more intense hypofractionation (between 2. Read More

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The Relationships Between Radiation Dosage and Long-term Swallowing Kinematics and Timing in Nasopharyngeal Carcinoma Survivors.

Dysphagia 2021 Apr 28. Epub 2021 Apr 28.

Department of Surgery, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China.

This study aimed to investigate the relationship between intensity-modulated radiation therapy (IMRT) dosimetry and swallowing kinematic and timing measures. Thirteen kinematic and timing measures of swallowing from videofluoroscopic analysis were used as outcome measures to reflect swallowing function. IMRT dosimetry was accessed for thirteen swallowing-related structures. Read More

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Vocal-cord Only vs. Complete Laryngeal radiation (VOCAL): a randomized multicentric Bayesian phase II trial.

BMC Cancer 2021 Apr 22;21(1):446. Epub 2021 Apr 22.

Radiation Oncology Department, Western University, London, Ontario, Canada.

Background: Radiotherapy, along with laser surgery, is considered a standard treatment option for patients with early glottic squamous cell cancer (SCC). Historically, patients have received complete larynx radiotherapy (CL-RT) due to fear of swallowing and respiratory laryngeal motion and this remains the standard approach in many academic institutions. Local control (LC) rates with CL-RT have been excellent, however this treatment can carry significant toxicities include adverse voice and swallowing outcomes, along with increased long-term risk of cerebrovascular morbidity. Read More

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Comparison of treatment modalities for selected advanced laryngeal squamous cell carcinoma.

Eur Arch Otorhinolaryngol 2021 Apr 17. Epub 2021 Apr 17.

Department of Otorhinolaryngology, NHC Key Laboratory of Otorhinolaryngology (Shandong University), Qilu Hospital of Shandong University, Jinan, Shandong, China.

Purpose: The authors aimed to clarify the optimal treatment strategy and the indication of different treatments in managing advanced laryngeal squamous cell carcinoma (LSCC).

Methods: A total of 9700 patients with advanced (T3-4aN0-3M0) LSCC who treated with (1) surgery alone, (2) surgery plus adjuvant radiation with or without chemotherapy (aCRT/RT), or (3) definitive CRT/RT was retrieved from the SEER database. The propensity score matching (PSM) was applied to balance confounding factors. Read More

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A randomized controlled trial comparing McGRATH series 5 videolaryngoscope with the Macintosh laryngoscope for nasotracheal intubation.

J Anaesthesiol Clin Pharmacol 2020 Oct-Dec;36(4):477-482. Epub 2021 Jan 18.

Department of Anaesthesia Critical Care and Pain, Tata Memorial Centre, Dr Ernest Borges Road, Parel, Mumbai, Maharashtra, India.

Background And Aims: The aim of this study was to compare the efficacy of McGRATH series 5 videolaryngoscope (VL) with Macintosh laryngoscope for nasotracheal intubation (NTI) in patients without anticipated difficult airways undergoing head and neck cancer surgeries.

Material And Methods: We randomized 60 adult patients for NTI by experienced anesthetists with either Macintosh laryngoscope or McGRATH series 5 VL (VL group). The primary objective was to compare time taken for intubation (TTI). Read More

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January 2021

TLM Outcomes in Elderly Patients with Glottic Pre-Malignancy and Early Malignancy; A 12-Year Retrospective Study.

Ann Otol Rhinol Laryngol 2021 Apr 9:34894211007819. Epub 2021 Apr 9.

Castle Hill Hospital, Cottingham, Hull, UK.

Introduction: UK population ageing and associated cancer risk predicts an increase in the prevalence of laryngeal cancer in elderly patients. Whilst trans-oral laser microsurgery (TLM) has been demonstrated to achieve excellent control of early disease with few complications, data specifically related to its safety and efficacy in older patients is lacking. We report the largest series to date. Read More

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Stereotactic body radiotherapy for T1 glottic cancer: dosimetric data in 27 consecutive patients.

Tumori 2021 Apr 6:3008916211000440. Epub 2021 Apr 6.

Department of Physics, IRCCS Regina Elena National Cancer Institute, Rome, Italy.

Aim: Because the clinical feasibility of stereotactic body radiotherapy (SBRT) for early glottic cancer (T1) is controversial, we report dosimetric results in 27 consecutive patients from a prospective phase I and II study that started in 2017.

Methods: In our approach, only the parts of the true vocal cord containing cancer and those immediately adjacent are planned to be treated to 36 Gy and 30 Gy, respectively, in 3 fractions. Several dosimetric metrics for both target volumes and organs at risk were extracted from individual plans and results were compared to those achieved by other authors in a similar setting. Read More

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Novel predictive tools and therapeutic strategies for patients with initially diagnosed glottic cancer in the United States.

Eur Arch Otorhinolaryngol 2021 Apr 5. Epub 2021 Apr 5.

Department of Otorhinolaryngology, School of Medicine, The Second Affiliated Hospital, Zhejiang University, 88 Jiefang Road, Hangzhou, 310009, Zhejiang, China.

Objective: The objective of this study is to identify valuable prognostic factors, build clinical prediction nomograms, and recommend the optimal therapeutic strategy for patients with initially diagnosed glottic cancer.

Methods: Patients were extracted from the SEER database. Cox regression analyses, survival analyses, an internal validation, the propensity score analysis, and the competing risk analysis were performed. Read More

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Could Primary Chemoradiotherapy in T2 Glottic Cancers Yield Results Comparable to Primary Radiotherapy in T1? Considerations from 531 German Early Stage Patients.

Cancers (Basel) 2021 Mar 31;13(7). Epub 2021 Mar 31.

Heidelberg Institute of Global Health, University of Heidelberg, 69120 Heidelberg, Germany.

T1 glottic cancer is a highly treatable disease with local control (LC) rates over 90% by either primary radiotherapy (pRT) or transoral laser microsurgery (TLM). LC of T2 glottic cancers is 15 percent points poorer on average. However, salvage after pRT entails more than 50% total laryngectomy. Read More

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T1a Glottic Cancer: Advances in Vocal Outcome Assessment after Transoral CO-Laser Microsurgery Using the VEM.

J Clin Med 2021 Mar 17;10(6). Epub 2021 Mar 17.

Department of Audiology and Phoniatrics, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Campus Charité Mitte, Charitéplatz 1, D-10117 Berlin, Germany.

Patients with unilateral vocal fold cancer (T1a) have a favorable prognosis. In addition to the oncological results of CO transoral laser microsurgery (TOLMS), voice function is among the outcome measures. Previous early glottic cancer studies have reported voice function in patients grouped into combined T stages (Tis, T1, T2) and merged cordectomy types (lesser- vs. Read More

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[Applied value of color Doppler flow imaging in diagnosis of congenital subglottic haemangioma in infant].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2021 Apr;35(4):321-324

Department of Otolaryngology,Qilu Children's Hospital of Shandong University,Ji'nan,250022,China.

To investigate the value of color Doppler flow imaging(CDFI) in the diagnosis of congenital subglottic hemangioma(CSH) in infants. The data of 18 children with CSH who underwent laryngeal CDFI examination were collected and analyzed retrospectively, and compared with those who underwent laryngeal ultrasound examination at the same time. The shape, size, blood flow characteristics of the tumor and its relationship with airway were observed. Read More

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[Pathologic tumor volume predicting survival outcomes of patients with local advanced glottic carcinoma].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2021 Apr;35(4):316-320

Department of Otolaryngology Head and Neck Surgery,Eye & ENT Hospital of Fudan University,Shanghai,200031,China.

The aim of this study was to evaluate the predicting role of tumor volume as evaluated by postoperative pathologic examination on overall survival(OS) and disease free survival(DFS) in patients with local advanced glottic carcinoma. In this study, the records of 406 consecutive patients with local advanced glottic carcinoma(T3-T4 stages) who underwent surgery ± chemoradiotherapy from January 2005 to December 2010 were retrospectively reviewed and followed up. The demographic characteristics, disease staging, and pathologic tumor volume were analyzed. Read More

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pT3 N0 Laryngeal Squamous Cell Carcinoma: Oncologic Outcomes and Prognostic Factors of Surgically Treated Patients.

Laryngoscope 2021 Mar 23. Epub 2021 Mar 23.

Otorhinolaryngology Head and Neck Surgery Department, University Hospital of Modena, Modena, Italy.

Objectives/hypothesis: To assess the disease control, survival rates, and prognostic factors of exclusive surgical treatment for patients with pT3 N0 laryngeal squamous cell carcinoma (LSCC).

Study Design: Multicentric retrospective cohort study.

Methods: Multicentric retrospective case series of previously untreated patients with pT3 R0N0 LSCC, who received exclusive surgery between 2011 and 2019. Read More

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Mu-Opioid Receptor Expression in Laryngeal Cancer.

J Voice 2021 Mar 7. Epub 2021 Mar 7.

Department of Otolaryngology Head and Neck Surgery, Rabin Medical Center, Petach Tikva, Israel; Sackler Faculty of Medicine, Tel-Aviv University, Tel Aviv Israel. Electronic address:

Objectives: Expression of mu-opioid receptors (MORs) has not been investigated in head and neck cancer. In this study, we aimed to assess the expression of opioids receptors in laryngeal cancer, compared to adjacent non-malignant tissue.

Study Design: A retrospective case series in a single academic center. Read More

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Evolution of voice after transoral laser cordectomy for precancerous lesions and early glottic cancer.

Eur Arch Otorhinolaryngol 2021 Mar 18. Epub 2021 Mar 18.

Department of Otorhinolaryngology and Head and Neck Surgery, University Hospital Ostrava, 17. Listopadu 1790, 708 52, Ostrava, Czech Republic.

Purpose: To evaluate voice quality evolution after a transoral laser cordectomy (TLC) for precancerous lesions and early glottic cancer.

Methods: This prospective study enrolled 18 patients scheduled for TLC for high-grade dysplasia, Tis, T1, and T2 glottic squamous cell cancers, from May 2017 to March 2020. Patients were grouped according to the extent of TLC: Group I (n = 11, 61. Read More

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Early glottic cancer recurrence: A critical review on its current management.

Crit Rev Oncol Hematol 2021 Apr 11;160:103298. Epub 2021 Mar 11.

Department of Otorhinolaryngology, Careggi University Hospital, Largo Brambilla 3, 50134, Florence, Italy; Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy.

Introduction: Recurrent early glottic cancer (rEGC) poses several issues in terms of timely diagnosis, correct re-staging, and treatment. We want to critically review the latest evidence about rEGC considering its epidemiology, biology, diagnostic challenges, and treatment strategies.

Methods: A systematic search of the literature using PubMed from 1990 to October 31, 2020 was performed. Read More

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Preclinical experience with a novel single-port platform for transoral surgery.

Surg Endosc 2021 Mar 12. Epub 2021 Mar 12.

Division of Head and Neck Surgery, Department of Surgery, University of California San Diego, San Diego, CA, USA.

Background: We investigated a novel minimally invasive surgical platform for use in the oropharynx, hypopharynx, and larynx for single-port transoral surgery used in concert with standard transoral laryngeal and pharyngeal instrumentation.

Methods: The preclinical investigational device by Fortimedix Surgical B.V. Read More

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Validation of the European Laryngological Society classification of glottic vascular changes as seen by narrow band imaging in the optical biopsy setting.

Eur Arch Otorhinolaryngol 2021 Mar 12. Epub 2021 Mar 12.

IRCCS Ospedale Policlinico San Martino, Genoa, Italy.

Purpose: In 2016, the European Laryngological Society (ELS) proposed a classification for vascular changes occurring in glottic lesions as visible by narrow band imaging (NBI), based on the dichotomic distinction between longitudinal vessels (not suspicious) and perpendicular ones (suspicious). The aim of our study was to validate this classification assessing the interobserver agreement and diagnostic test performance in detecting the final histopathology.

Methods: A retrospective study was carried out by reviewing clinical charts, preoperative videos, and final pathologic diagnosis of patients submitted to transoral microsurgery for laryngeal lesions in two Italian referral centers. Read More

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[Clinical-pathological characterization of laryngeal cancer in the Mexican population].

Rev Med Inst Mex Seguro Soc 2021 02 2;59(1):27-33. Epub 2021 Feb 2.

Instituto Mexicano del Seguro Social, Unidad de Medicina Familiar No. 178, Departamento de Enseñanza, Zapopan, Jalisco, México.

Background: Cancer of the larynx occupies the first frequency site of cancer of the upper digestive tract and represents 42% of malignant neoplasms of the upper aero-digestive tract. It is a potentially curable entity if it is diagnosed in early stages.

Objective: Characterize the clinical pathological features of patients with laryngeal cancer, which can serve as a guide for diagnostic suspicion in primary and secondary care. Read More

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February 2021

Current indications for adjuvant treatment following transoral laser microsurgery of early intermediate laryngeal cancer.

Curr Opin Otolaryngol Head Neck Surg 2021 Apr;29(2):79-85

Otorhinolaryngology-Head and Neck Surgery, Leuven Cancer Institute, University Hospitals Leuven and Department of Oncology - Section Head and Neck Oncology.

Purpose Of Review: This review summarizes the information in the literature on the indications for adjuvant therapy after transoral laser microsurgery (TLM) for early/intermediate stage laryngeal cancer.

Recent Findings: A high rate of 'nonevaluable' margins after TLM significantly complicates decision-making concerning adjuvant therapy. However, consensus grows that second-look TLM in patients with multiple superficial and deep positive margins is more sensible than sending these patients systematically for adjuvant radiotherapy (RT). Read More

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Radiotherapy versus partial laryngectomy in the management of early glottic cancer with anterior commissure involvement: A propensity score matched study with 256 patients.

Oral Oncol 2021 Feb 26;116:105230. Epub 2021 Feb 26.

Department of Radiation Oncology, Eye, Ear, Nose & Throat Hospital of Fudan University, Shanghai 200031, China. Electronic address:

Objectives: The study was intended to compare the outcomes for T1-T2N0M0 glottic squamous cell carcinoma with anterior commissure involvement who had undergone partial laryngectomy (PL) or radiotherapy (RT).

Materials And Methods: We retrospectively analyzed 256 patients who were treated by RT (n = 70) or PL (n = 186). Patients received prophylactic irradiation of the neck in RT group whereas PL was not associated with lymphadenectomy. Read More

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February 2021

Seeking Medical Assistance for Dysphonia Is Associated with an Improved Survival Rate in Laryngeal Cancer: Real-World Evidence.

Diagnostics (Basel) 2021 Feb 7;11(2). Epub 2021 Feb 7.

Department of Otolaryngology Head and Neck Surgery, Linkou Chang Gung Memorial Hospital, No. 5 Fushing St., Taoyuan 333, Taiwan.

(1) Background: Patients with laryngeal cancer usually present with dysphonia. However, some studies reported that the duration from dysphonia to cancer diagnosis has been prolonged significantly in recent years. This study aimed to evaluate that in the initial dysphonia-related diagnosis and the interval between the diagnosis of laryngeal cancer may affect the overall survival (OS). Read More

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February 2021

[Study on the measurement of glottic proportion in subjects with normal larynx].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2021 Feb;35(2):152-155

Department of Otolaryngology Head and Neck Surgery,Sixth Medical Center of PLA General Hospital,College of Otolaryngology Head and Neck Surgery,Chinese PLA General Hospital,National Clinical Research Center for Otolaryngologic Diseases,Beijing,100048,China.

The aim of this study is to explore the glottic proportion(GP) and gender difference in Chinese subjects with normal larynx. Two hundred patients with normal larynx in Sixth Medical Center of PLA General Hospital from January 2017 to December 2019 were selected as the experimental group. Group 1 included 100 females and group 2 included 100 males. Read More

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February 2021

Postoperative Radiotherapy Omitting Level Ⅳ for Locally Advanced Supraglottic and Glottic Laryngeal Carcinoma.

Technol Cancer Res Treat 2021 Jan-Dec;20:1533033820985876

School of Public Health, Xuzhou Medical University, Xuzhou, People's Republic of China.

Background: Cervical lymph nodes metastases are one of the most significant prognostic factors in patients with laryngeal carcinoma, whether treatment by surgery or by radiotherapy. The current study retrospected the postoperative radiotherapy of locally advanced supraglottic and glottic laryngeal carcinoma (at a greater risk of lymph node metastasis) to determine the effect of radiotherapy excluding cervical level Ⅳ lymph nodes.

Methods: Patients of supraglottic type and glottic type were irradiated with level Ⅳ from January 2012 to June 2013, without level Ⅳ from July 2013 to December 2014, according to physicians' decision. Read More

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February 2021