6,137 results match your criteria Glottic Cancer


Change in Voice Quality after Radiotherapy for Early Glottic Cancer.

Cancers (Basel) 2022 Jun 17;14(12). Epub 2022 Jun 17.

Faculty of Medicine, University of Ljubljana, Vrazov trg 2, 1000 Ljubljana, Slovenia.

Our aim was to track the changes in voice quality for two years after radiotherapy (RT) for early glottic cancer. A videoendostroboscopy, subjective patient and phoniatrician voice assessments, a Voice Handicap Index questionnaire, and objective acoustic measurements (F jitter, shimmer, maximal phonation time) were performed on 50 patients with T1 glottic carcinomas at 3, 12, and 24 months post-RT. The results were compared between the subsequent assessments, and between the assessments at 3 months and 24 months post-RT. Read More

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Clinical and functional characteristics of lung surgery-related vocal fold palsy.

Biomed J 2021 Dec 27;44(6S1):S101-S109. Epub 2020 Jul 27.

Department of Physical Medicine and Rehabilitation, Taichung Hospital, Ministry of Health and Welfare, Taichung, Taiwan; Department of Otolaryngology Head and Neck Surgery, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan; Healthy Aging Research Center, Chang Gung University, Taoyuan, Taiwan; Center of Vascularized Tissue Allograft, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan. Electronic address:

Background: Unilateral vocal fold paralysis (UVFP) caused by lung surgery is associated with prolonged hospital stay and increased postoperative comorbidities. We evaluated lung surgery-related UVFP and compared its characteristics with UVFP caused by esophageal and thyroid surgeries, as the most common surgical causes of UVFP. We also evaluated the outcomes of intracordal hyaluronate injection laryngoplasty in these patients. Read More

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December 2021

Vocal Outcome After Cordectomy by Transoral CO Laser Microsurgery in Patients With Laryngeal Intraepithelial Neoplasia and Non-neoplastic Lesions.

J Voice 2022 Jun 19. Epub 2022 Jun 19.

Department of Oto-Rhino-Laryngology - Head & Neck Surgery and Audiology, Odense University Hospital, Odense, Denmark.

Objectives: This study investigates vocal outcome after cordectomy by transoral CO laser microsurgery (TLM-cordectomy) in patients with laryngeal intra-epithelial neoplasia (LIN) or non-neoplastic lesions (NNL), for improved individual patient advice and potential adjustment of national treatment strategy by which patients suspected to have glottic LIN or T1a cancer are offered TLM-cordectomy, without prior biopsy.

Study Design: Prospective, longitudinal, quasi-experimental time series.

Methods: Consecutively included patients (n = 155) with LIN (n = 84) or NNL (n = 71) who underwent voice assessments before and after TLM-cordectomy. Read More

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Transoral robotic cordectomy for glottic carcinoma: a rapid review.

Eur Arch Otorhinolaryngol 2022 Jun 22. Epub 2022 Jun 22.

Department of Otorhinolaryngology and Head and Neck Surgery, Foch Hospital, School of Medicine, UFR Simone Veil, Université Versailles Saint-Quentin-en-Yvelines (Paris Saclay University), Paris, France.

Objective: The objective of this study was to investigate feasibility, surgical, oncological, and functional outcomes of transoral robotic cordectomy (TORS-Co) and whether TORS-Co reported comparable outcomes of transoral laser microsurgery (TLM).

Methods: PubMed, Scopus, and Cochrane Library were searched by three laryngologists for studies investigating feasibility, surgical, oncological, and functional outcomes of patients benefiting from TORS-Co. The following outcomes were investigated according to the PRISMA statements: age; cT stage; types of cordectomy; surgical settings; complications; and functional and feasibility features. Read More

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Laryngeal function-preserving of frontolateral vertical partial laryngectomy (FLVPL) for selected T4a glottic cancer with thyroid cartilage invasion adherence to the anterior commissure: an innovative attempt.

Eur Arch Otorhinolaryngol 2022 Jun 9. Epub 2022 Jun 9.

State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University Cancer Center, Guangzhou, 510060, Guangdong, China.

Objective: To evaluate the feasibility and efficacy in selected T4a glottic cancer (thyroid cartilage invasion adherence to the anterior commissure) treated with frontolateral vertical partial laryngectomy (FLVPL) and laryngeal framework reconstruction using titanium mesh.

Methods: Six patients with the limited T4a glottic cancer with thyroid cartilage destruction adherence to the anterior commissure, underwent FLVPL from 2009 to 2016 in Sun Yat-Sen University Cancer Center. All patients were followed up postoperatively. Read More

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Epidemiological, clinical and oncological outcomes of young patients with laryngeal cancer: a systematic review.

Eur Arch Otorhinolaryngol 2022 Jun 2. Epub 2022 Jun 2.

Laryngeal and Head and Neck Surgery Study Groups of Young-Otolaryngologists of the International Federations of Oto-Rhino-Laryngological Societies (YO-IFOS), Paris, France.

Objective: To investigate epidemiological, clinical and oncological outcomes of young patients with laryngeal cancer (LC).

Methods: PubMed, Scopus and Cochrane Library were searched by three researchers for studies investigating epidemiological, clinical and oncological outcomes of patients with age < 40 years old and LC. The following outcomes were investigated with PRISMA criteria: age; ethnicity; gender; tobacco/alcohol habits; anatomical, pathological, therapeutic and survival features. Read More

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Expanded Basal Compartment and Disrupted Barrier in Vocal Fold Epithelium Infected with Mouse Papillomavirus MmuPV1.

Viruses 2022 05 16;14(5). Epub 2022 May 16.

Department of Surgery, University of Wisconsin-Madison, Madison, WI 53705, USA.

Laryngeal infection with low-risk human papillomaviruses can cause recurrent respiratory papillomatosis (RRP), a disease with severe effects on vocal fold epithelium resulting in impaired voice function and communication. RRP research has been stymied by limited preclinical models. We recently reported a murine model of laryngeal MmuPV1 infection and disease in immunodeficient mice. Read More

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Swallowing function improvement using costal cartilage for severe dysphagia after supracricoid hemilaryngopharyngectomy.

Auris Nasus Larynx 2022 May 20. Epub 2022 May 20.

Department of Otolaryngology, Head and Neck Surgery, Graduate School of Medicine, Kyoto University, Kyoto, 54 Shogoin Kawahara-cho, Sakyo-ku, Kyoto 606-8507, Japan.

Supracricoid hemilaryngopharyngectomy (SCHLP) is a laryngeal preservation surgery for hypopharyngeal carcinoma confined to the pyriform sinus or laryngeal carcinoma with arytenoid infiltration. Postoperative dysphagia is inevitable, but both voice and swallowing functions can be preserved. Here, we present a case of severe dysphagia secondary to unexpected postoperative tissue loss and scarring. Read More

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Outcomes of carotid sparing intensity-modulated radiotherapy for early stage glottic cancer in 201 patients: Multicenter study of Turkish Radiation Oncology Society/TROD-01-007.

Head Neck 2022 May 21. Epub 2022 May 21.

Department of Radiation Oncology, Medical School, Dokuz Eylul University, Izmir, Turkey.

Background: To assess and report clinical outcomes after carotid sparing intensity-modulated radiotherapy for early stage laryngeal cancer.

Methods: We retrospectively analyzed 201 patients with early stage glottic laryngeal cancer treated with carotid sparing intensity-modulated radiotherapy (IMRT)/volumetric modulated arc therapy (VMAT) techniques in six TROD centers.

Results: After a median follow-up of 31 months the actuarial 1- and 3-year local and locoregional control rates were 99. Read More

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[Larynx preservation: recommendations for decision-making in T3 laryngeal cancer patients].

HNO 2022 May 16. Epub 2022 May 16.

Heidelberger Institut für Global Health, Universität Heidelberg, Heidelberg, Deutschland.

Background: By today's standard, the optimal treatment of every individual tumor patient is discussed and determined in an interdisciplinary tumor board. According to the new S3 guidelines, larger volume T3 laryngeal cancers which are no longer safely resectable with larynx-sparing surgery are ideal candidates for a larynx preservation approach using primary chemoradiation (pCRT). So far, no clear criteria have been defined under what circumstances primary radiotherapy alone (pRT) might be acceptable in case chemotherapy (CT) is prohibited or in what cases, even in T3, upfront total laryngectomy with risk-adapted adjuvant treatment (TL±a[C]RT) should be recommended. Read More

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Effect of treatment modality on the long-term survival of patients with early glottic squamous cancer: a retrospective cohort study based on the SEER database.

Ann Transl Med 2022 Apr;10(8):440

Department of Otorhinolaryngology-Head and Neck Surgery, Peking University People's Hospital, Beijing, China.

Background: The optimal treatment strategy for patients with early glottic (T1-2N0M0) squamous cancer remains unclear.

Methods: A retrospective population-based analysis was performed using the Surveillance, Epidemiology, and End Results (SEER) database. Propensity score matching (PSM) was used to balance treatment arms, and Cox regression analysis was used to determine prognostic factors for survival. Read More

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A Comparison of McGrath Videolaryngoscope versus Macintosh Laryngoscope for Nasotracheal Intubation: A Systematic Review and Meta-Analysis.

J Clin Med 2022 Apr 29;11(9). Epub 2022 Apr 29.

Department of Anesthesiology, Far Eastern Memorial Hospital, Banqiao Dist., New Taipei City 220, Taiwan.

Background: In this study, it was shown that the routine use of McGrath videolaryngoscopy may improve intubation success rates. The benefits to using a videolaryngoscope in nasotracheal intubation were also demonstrated. However, no solid evidence concerning the effectiveness of the use of McGrath videolaryngoscopes in nasotracheal intubation has previously been reported. Read More

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Unilateral vocal cord finding on PET-CT in a small cell lung cancer patient - another cause?

Am J Med Sci 2022 May 8. Epub 2022 May 8.

Pulmonology Department, Centro Hospitalar e Universitário de São João, Porto, Portugal.

A 60-year-old man diagnosed with small cell lung cancer, stage IV, presented an excellent response after first line therapy with chemotherapy (6 cycles of Carboplatin + Etoposid), with thoracic computed tomography showing a significant shrinking of the left hilar mass, pulmonary nodules, and mediastinal adenopathies (fig.1A - before; fig.1B - after chemotherapy). Read More

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Comparison between C-MAC and King Vision video laryngoscope (channelled blade) for tracheal intubation in aerosol-prevention intubation box for COVID-19 patients: A manikin-based study.

Indian J Anaesth 2022 Mar 24;66(3):187-192. Epub 2022 Mar 24.

Department of Onco-Anaesthesia and Palliative Medicine, IRCH, AIIMS, New Delhi, India.

Background And Aims: The risk of contracting infection while intubating a coronavirus disease 2019 (COVID-19)-positive patient can be reduced by the use of personal protective equipment (PPE), video laryngoscope (VL) and aerosol-preventing intubation box. We compared two VLs (C-MAC and King Vision laryngoscope [KVL]) for ease of intubation and time taken to intubate the manikin using an intubation box.

Methods: This randomised study involved healthcare workers having experience in using both C-MAC and KVL. Read More

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Preliminary dynamic observation of wound healing after low-temperature plasma radiofrequency ablation for laryngeal leukoplakia.

Acta Otolaryngol 2022 Mar-Apr;142(3-4):350-356. Epub 2022 Apr 26.

Department of Otolaryngology, the Second Hospital of Hebei Medical University, Shijiazhuang, China.

Background: Low-temperature plasma ablation (LTPA) is an emerging technique for laryngeal leukoplakia (LL).

Objective: To initially observe the healing process of trauma after LTPA for LL.

Materials And Methods: Seventeen patients who underwent LTPA for LL were collected, and the degrees of wound healing were analyzed. Read More

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Serum expression of Vascular Endothelial-Cadherin, CD44, Human High mobility group B1, Kallikrein 6 proteins in different stages of laryngeal intraepithelial lesions and early glottis cancer.

PeerJ 2022 19;10:e13104. Epub 2022 Apr 19.

Department of Otorhinolaryngology Head and Neck Surgery, Medical University of Warsaw, Warsaw, Poland.

Background: The study was designed to evaluate the potential validity and utility of selected molecular markers in serum samples from patients with specific stages of laryngeal intraepithelial lesions that could serve as diagnostic tools in differentiation of benign and dysplastic lesions from invasive pathologies.

Methods: Prospective study included 80 consecutive patients with vocal fold lesions treated at the single otorhinolaryngology centre. All participants had surgical resection of the lesion. Read More

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Video-Assisted Intubating Stylet Technique for Difficult Intubation: A Case Series Report.

Healthcare (Basel) 2022 Apr 15;10(4). Epub 2022 Apr 15.

Division of Otolaryngology-Head and Neck Surgery, LifeBridge Sinai Hospital, Baltimore, MD 21215, USA.

Induction of anesthesia can be challenging for patients with difficult airways and head or neck tumors. Factors that could complicate airway management include poor dentition, limited mouth opening, restricted neck motility, narrowing of oral airway space, restricted laryngeal and pharyngeal space, and obstruction of glottic regions from the tumor. Current difficult airway management guidelines include awake tracheal intubation, anesthetized tracheal intubation, or combined awake and anesthetized intubation. Read More

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Application of a Simulator-Based Teaching Method in the Training of the Flexible Bronchoscope-Guided Intubation.

Curr Health Sci J 2021 Oct-Dec;47(4):501-506. Epub 2021 Dec 31.

Department of Respiratory&Critical Care Medicine, Changhai Hospital, the Second Military Medical University, Shanghai, China.

Background: The study aimed to explore the effect of a bronchoscopic simulator-based comprehensive teaching method in the training of flexible bronchoscope-guided intubation for suspected lung cancer patients for doctors without bronchofibroscopic operation background.

Methods: We designed a prospective self-control study involved in 35 trainees from the Navy Military Medical University's affiliated hospital to evaluate flexible bronchoscope-guided intubation's training outcome. Before and after the practice training, we recorded the flexible bronchoscope passing time from nasal to visible glottis and carina, tracheal placement tube, and ventilation. Read More

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December 2021

In Reference to Radiological Findings in Laryngeal Anterior Commissure Invasion: CT Scan Highlights.

Laryngoscope 2022 Jul 19;132(7):E27. Epub 2022 Apr 19.

Department of Oto-Rhino-Laryngology and Head and Neck Surgery, All India Institute of Medical Sciences, New Delhi, India.

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Voice Outcome After Carbon Dioxide Transoral Laser Microsurgery for Glottic Cancer According to the European Laryngological Society Classification of Cordectomy Types - A Systematic Review.

J Voice 2022 Apr 11. Epub 2022 Apr 11.

Coordinator of the International Head and Neck Scientific Group, Padua, Italy.

Background: Voice outcome after carbon dioxide transoral laser microsurgery (COTOLMS) for glottic cancer is of prime importance. However, a comprehensive overview according to the European Laryngological Society (ELS) classification of cordectomies is still lacking. The aim of this systematic review is to summarize data on voice outcome associated with individual types of ELS glottic cordectomy after COTOLMS. Read More

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Multimodal Evaluation of Voice Outcome in Early Glottic Cancers Treated With Definitive Radiotherapy.

Cancer Diagn Progn 2021 Jul-Aug;1(3):143-149. Epub 2021 Jul 3.

Department of Radiation Oncology, SS. Annunziata Hospital, "G. D'Annunzio" University of Chieti, Chieti, Italy.

Background/aim: We employed a multimodal evaluation of voice outcome (MEVO) model to assess long-term voice outcome in early glottic cancer (EGC) patients treated with primary radiotherapy (RT). The model consisted of objective and subjective vocal evaluation during follow-up, by a dedicated Speech Pathologist and Speech Therapist.

Patients And Methods: MEVO methodology includes Self-perception Voice Handicap Index (VHI-30), evaluation of parameters Grade (G), Roughness (R), Breathiness (B), Asthenia (A) and Strain (S) according to GRBAS scale, objective analysis and aerodynamics using the PRAAT software and laryngeal evaluation with videostroboscope (VS). Read More

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Oropharyngeal Geometry of Maxilectomized Patients Rehabilitated with Palatal Obturators in the Trans-surgical Period: Repercussions on the Voice.

J Voice 2022 Apr 6. Epub 2022 Apr 6.

Graduate Program in Dentistry at the Federal University of Pernambuco, Department of Clinical and Preventive Dentistry, Health Sciences Center, Recife, Pernambuco, Brazil.

Introduction: Patients undergoing maxillectomies may present alterations in the stomatognathic functions involved in oral communication. Rehabilitative treatment should favor the rescue of these functions, through surgical flaps, obturator prostheses or both.

Objectives: The present study aims to present the impact of the use of the palatal obturator on the oropharyngeal geometry and on the voice of patients undergoing maxillectomies, after adaptation to trans-surgical palatine obturators (TPO). Read More

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Application of digital modeling and three-dimensional printing of titanium mesh for reconstruction of thyroid cartilage in partial laryngectomy.

Acta Otolaryngol 2022 Mar-Apr;142(3-4):363-368. Epub 2022 Apr 8.

School of Materials Science and Engineering, Central South University, Changsha, China.

Background: Digital modeling and three-dimensional (3D) printing techniques have been used to assist the resection of the laryngeal lesions and repair the remnant larynx in glottic cancer patients with anterior commissure involvement.

Aims/objectives: To evaluate the feasibility of digital modeling and 3D printing of titanium mesh for thyroid cartilage reconstruction in partial laryngectomy, and compare the advantages and disadvantages with crico-hyoido-epiglottopexy (CHEP).

Material And Methods: Forty-four glottic cancer patients with anterior commissure involvement were randomly assigned into group A and group B. Read More

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Effects of Medical Masks on Voice Quality in Patients With Voice Disorders.

J Speech Lang Hear Res 2022 05 1;65(5):1742-1750. Epub 2022 Apr 1.

Department of Otolaryngology-Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, China.

Purpose: The purpose of this study was to explore the effects of medical masks on the voice quality of patients with voice disorders.

Method: We included 106 patients diagnosed with voice disorders. Among them, 59 were diagnosed with vocal-fold benign lesions, 27 with insufficient glottis closure, and 20 with precancerous lesions/early-stage glottic carcinoma. Read More

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Comparative evaluation of glidescope videolaryngosocope and conventional macintosh laryngoscope for nasotracheal intubation in patients undergoing oropharyngeal cancer surgeries: A prospective randomized study.

J Anaesthesiol Clin Pharmacol 2021 Oct-Dec;37(4):542-547. Epub 2021 Nov 25.

Department of Onco-Anesthesiology and Palliative Medicine, BRAIRCH, AIIMS, Ansari Nagar, New Delhi, India.

Background And Aims: Nasotracheal intubation in oropharyngeal cancer patients is challenging owing to anatomical alterations. Various videolaryngoscopes have been compared to conventional laryngoscope and also amongst each other in different clinical scenarios; the supremacy of videolaryngoscopes over conventional laryngoscope in oropharyngeal cancer patients is yet to be established. We compared the efficacy of glidescope videolaryngoscopes and Macintosh laryngoscope for nasotracheal intubation in patients posted for routine oropharyngeal cancer. Read More

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November 2021

Injection laryngoplasty during transoral laser microsurgery for early glottic cancer: a randomized controlled trial.

J Otolaryngol Head Neck Surg 2022 Mar 22;51(1):12. Epub 2022 Mar 22.

Queen Elizabeth II Health Sciences Centre, 3rd Floor Dickson Building, 5820 University Avenue, Halifax, NS, B3H 1Y9, Canada.

Background: Transoral laser microsurgery is widely used for treating T1/T2 glottic cancers. Hyaluronic acid (HA) is commonly used in vocal cord augmentation. We investigated the impact of intra-operative injection laryngoplasty on voice outcomes in early glottic cancer. Read More

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Genetic polymorphisms and protein levels in vocal fold leukoplakia: a systematic review.

Braz J Med Biol Res 2022 11;55:e11920. Epub 2022 Mar 11.

Laboratório de Biologia Molecular, Centro de Oncohematologia Pediátrica, Hospital Universitário Oswaldo Cruz, Universidade de Pernambuco, Recife, PE, Brasil.

Vocal fold leukoplakia (VFL) has a risk of malignant transformation. Therefore, patients can have symptoms such as dysphonia, vocal strain, difficulty breathing, and dysphagia. Additionally, there is a genetic predisposition that can be associated with genetic polymorphisms. Read More

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Radiomics of dual-energy computed tomography for predicting progression-free survival in patients with early glottic cancer.

Future Oncol 2022 May 16;18(15):1873-1884. Epub 2022 Mar 16.

Department of Radiology, Tianjin First Central Hospital, School of Medicine, Nankai University, No. 24 Fukang Road, Nankai District, Tianjin, 300192, China.

This study aimed to predict progression-free survival (PFS) in patients with early glottic cancer using radiomic features on dual-energy computed tomography iodine maps. Radiomic features were extracted from arterial and venous phase iodine maps, and radiomic risk scores were determined by univariate Cox proportional hazards regression analysis and least absolute shrinkage and selection operator regression with tenfold cross-validation. The Kaplan-Meier method was used to evaluate the association between radiomic risk scores and PFS. Read More

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Single vocal cord irradiation for early-stage glottic cancer: Excellent local control and favorable toxicity profile.

Oral Oncol 2022 04 8;127:105782. Epub 2022 Mar 8.

Department of Radiotherapy, Erasmus MC Cancer Institute, University Medical Center Rotterdam, The Netherlands. Electronic address:

Objective: To validate the earlier reported promising oncologic outcomes and favorable toxicity profile following single vocal cord irradiation (SVCI) in an expanded cohort of patients with early-stage glottic cancer treated at our institute with longer follow-up time.

Materials And Methods: Between February 2011 and January 2020, 111 consecutive patients with early-stage glottic cancer were treated with SVCI to the whole involved vocal cord (58.08 Gy, given in 16 fractions of 3. Read More

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