5,758 results match your criteria Glottic Cancer


Chemoradiotherapy for high-risk stage II laryngeal cancer.

Int J Clin Oncol 2020 May 22. Epub 2020 May 22.

Division of Gastrointestinal Oncology, Shizuoka Cancer Center, 1007 Shimonagakubo, Nagaizumi, Sunto-gun, Shizuoka, 411-8777, Japan.

Background: Definitive radiotherapy (RT) for stage II laryngeal cancer is known to be less effective for locoregional control and survival (LRCS) in patients with high-risk factors (e.g., subglottic extension, impaired cord mobility, or bulky tumor size) than in low-risk patients. Read More

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http://dx.doi.org/10.1007/s10147-020-01705-xDOI Listing

Acupuncture for cancer-related hiccups: Protocol for a systematic review and meta-analysis of randomized controlled trials.

Medicine (Baltimore) 2020 May;99(20):e19973

Harbin Medical University Cancer Hospital, Harbin, China.

Background: Hiccups are involuntary contractions of the diaphragm and intercostal muscles, which lead to sudden contractions of the glottis. CAM, such as acupuncture is commonly used and stimulation of the vagus nerve and interference with phrenic nerve conduction are also used to treat hiccups. However, there is little evidence on the effectiveness of acupuncture for cancer-related hiccups. Read More

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http://dx.doi.org/10.1097/MD.0000000000019973DOI Listing

Perceptual and acoustic voice analysis in patients with glottis cancer after endoscopic laser cordectomy.

Otolaryngol Pol 2020 Feb;74(3):23-28

Zakład Fonoaudiologii Klinicznej i Logopedii, Uniwersytet Medyczny w Białymstoku.

<b>Introduction:</b> Treatment of glottis cancer, despite oncological safety, should consider postoperative voice quality. CO<sub>2</sub> laser endoscopic cordectomy allows radical removal of the tumor while maintaining respiratory, defensive and phonatory functions. <br><b>The aim:</b> The aim of the study is perceptual and acoustic evaluation of voice in patients after endoscopic CO2 III-Va laser cordectomy due to glottis cancer. Read More

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http://dx.doi.org/10.5604/01.3001.0013.7850DOI Listing
February 2020

Commentary about mesenchymal stem cells and scarred vocal folds.

Stem Cell Res Ther 2020 May 7;11(1):173. Epub 2020 May 7.

Therapy Department, Aix Marseille Univ, APHM, INSERM, CBT-1409, La Conception University Hospital, Cell, Marseille, France.

A commentary to "Hertegård, S., Nagubothu, S.R. Read More

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http://dx.doi.org/10.1186/s13287-020-01693-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7206705PMC

Moderate hypofractionation for early laryngeal cancer improves local control: a systematic review and meta-analysis.

Eur Arch Otorhinolaryngol 2020 May 6. Epub 2020 May 6.

Department of Radiation Oncology, National Cancer Institute, All India Institute of Medical Sciences, New Delhi, India.

Introduction: Radiation therapy is considered the standard treatment for early glottic cancers; and recent trials have evaluated the role of hypofractionation with mixed results. We conducted this systematic review and meta-analysis to assess the impact of hypofractionation in early glottic cancers.

Methods: We performed a comprehensive search of the PubMed, Embase and Google scholar to look for studies which have evaluated the role of hypofractionation in early glottic cancers. Read More

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http://dx.doi.org/10.1007/s00405-020-06012-9DOI Listing
May 2020
1.608 Impact Factor

Changes in Head and Neck Oncologic Practice During the COVID-19 Pandemic.

Head Neck 2020 May 1. Epub 2020 May 1.

Department of Otolaryngology- Head & Neck Surgery, University of Kansas, Kansas City, Kansas.

Introduction: The COVID-19 pandemic has raised controversies regarding safe and effective care of head and neck cancer patients. It is unknown how much the pandemic has changed surgeon practice.

Methods: A questionnaire was distributed to head and neck surgeons assessing opinions related to treatment and concerns for the safety of patients, self, family, and staff. Read More

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http://dx.doi.org/10.1002/hed.26233DOI Listing

Incidence of Occult Lymph Node Metastasis in Primary Larynx Squamous Cell Carcinoma, by Subsite, T Classification and Neck Level: A Systematic Review.

Cancers (Basel) 2020 Apr 24;12(4). Epub 2020 Apr 24.

International Head and Neck Scientific Group, 35100 Padua, Italy.

Background: Larynx cancer is a common site for tumors of the upper aerodigestive tract. In cases with a clinically negative neck, the indications for an elective neck treatment are still debated. The objective is to define the prevalence of occult metastasis based on the subsite of the primary tumor, T classification and neck node levels involved. Read More

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http://dx.doi.org/10.3390/cancers12041059DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7225965PMC

Comparison Between Early Glottic Carcinoma and Epithelial Dysplastic Lesions of the Vocal Fold Via Voice Analysis.

J Voice 2020 Apr 24. Epub 2020 Apr 24.

Department of Otolaryngology-Head and Neck Surgery, Chungnam National University Hospital, Daejeon, Republic of Korea. Electronic address:

Objective: Vocal fold leukoplakia is clinically defined by the presence of white mucosal lesions. Benign and malignant lesions of vocal fold leukoplakia can be distinguished clinically based on pathological biopsy. This study compared the acoustic and aerodynamic parameters of vocal cord carcinoma and dysplasia (mild to severe). Read More

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http://dx.doi.org/10.1016/j.jvoice.2020.03.005DOI Listing

Which risk factors are associated with stomal recurrence after total laryngectomy for laryngeal cancer? A meta-analysis of the last 30 years.

Braz J Otorhinolaryngol 2020 Apr 11. Epub 2020 Apr 11.

Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute, Department of Head and Neck Surgery, Liaoning Province, People's Republic of China. Electronic address:

Introduction: Stomal recurrence is a troublesome complication after total laryngectomy Despite a large number of studies having been performed, there is still controversy about which risk factors are most significant for the development of stomal recurrence.

Objective: The objective of the present meta-analysis was to analyze the potential factors leading to stomal recurrence after total laryngectomy.

Methods: PubMed, Web of Science, Cochrane Library, and Ovid databases were systematically searched using multiple search terms. Read More

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http://dx.doi.org/10.1016/j.bjorl.2020.03.002DOI Listing

Surgical Considerations for an Awake Tracheotomy During the COVID-19 Pandemic.

J Laparoendosc Adv Surg Tech A 2020 May 20;30(5):477-480. Epub 2020 Apr 20.

Department of Otolaryngology-Head and Neck Surgery, MedStar Georgetown University Hospital, Washington, DC, USA.

The current global COVID-19 pandemic is caused by the novel coronavirus Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2). Given that SARS-CoV-2 is highly transmissible, surgical societies have recommended that procedures with a high risk of aerosolization be avoided or delayed. However, some high-risk procedures, such as those related to head and neck malignancies, cannot always be delayed. Read More

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http://dx.doi.org/10.1089/lap.2020.0239DOI Listing

Transoral Laser Surgery for Adenosquamous Carcinoma of the Glottis: First Case Report and Review of the Literature.

Ear Nose Throat J 2020 Apr 8:145561320916576. Epub 2020 Apr 8.

Department of Otolaryngology, Sheffield Teaching Hospitals, Sheffield, United Kingdom.

Adenosquamous carcinoma of the head and neck is a rare cancer associated with poor prognosis. Histologically, it is identified through the presence of both adenocarcinoma and squamous cell carcinoma, although it may be difficult to diagnose from initial endoscopic biopsies. We report a case of adenosquamous carcinoma of the glottis in an 82-year-old female patient who presented with progressive hoarseness of voice and in whom initial biopsies had shown only moderate to severe dysplasia. Read More

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http://dx.doi.org/10.1177/0145561320916576DOI Listing

Comparison of Current Surgical and Non-Surgical Treatment Strategies for Early and Locally Advanced Stage Glottic Laryngeal Cancer and Their Outcome.

Cancers (Basel) 2020 Mar 20;12(3). Epub 2020 Mar 20.

Department of Otorhinolaryngology, Head and Neck Surgery, Inselspital, Bern University Hospital, University of Bern, CH-3010 Bern, Switzerland.

For the treatment of early and locally advanced glottic laryngeal cancer, multiple strategies are available. These are pursued and supported by different levels of evidence, but also by national and institutional traditions. The purpose of this review article is to compare and discuss the current evidence supporting different loco-regional treatment approaches in early and locally advanced glottic laryngeal cancer. Read More

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http://dx.doi.org/10.3390/cancers12030732DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7140062PMC

Intensity-modulated radiation therapy in early stage squamous cell carcinoma of the larynx: treatment trends and outcomes.

Radiat Oncol J 2020 Mar 25;38(1):11-17. Epub 2020 Mar 25.

Division of Radiation Oncology, Allegheny Health Network Cancer Institute, Pittsburgh, PA, USA.

Purpose: Definitive radiotherapy remains a primary treatment option for early stage glottic cancer. Intensity-modulated radiation therapy (IMRT) has emerged as the standard treatment technique for advanced head and neck cancers, whereas three-dimensional conformal radiotherapy (3D-CRT) has remained standard for early glottic cancers. We used the National Cancer Database (NCDB) to identify predictors of IMRT use and effect on outcome in these patients. Read More

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http://dx.doi.org/10.3857/roj.2019.00619DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7113149PMC

Clinicopathologic Aspects of Vocal Fold Leukoplakia in Smokers and Nonsmokers.

J Voice 2020 Mar 24. Epub 2020 Mar 24.

Division of Biomedical Statistics and Informatics, Mayo Clinic, Jacksonville, Florida.

Background: We aimed to investigate possible causes of leukoplakia and squamous cell carcinoma. We particularly sought to characterize the effect of smoking history because leukoplakia has been observed in nonsmokers.

Methods: We retrospectively identified patients with a diagnosis of leukoplakia who were treated at Mayo Clinic (Jacksonville, Florida), in the Department of Otorhinolaryngology, from 1/1/2006 through 8/31/2019. Read More

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http://dx.doi.org/10.1016/j.jvoice.2020.02.003DOI Listing

Oncological and Surgical Outcomes of Patients Treated by Transoral CO Laser Cordectomy for Early-Stage Glottic Squamous Cell Carcinoma: A Retrospective Chart Review.

Ear Nose Throat J 2020 Mar 23:145561320911486. Epub 2020 Mar 23.

Department of Otolaryngology-Head and Neck Surgery, Foch Hospital, School of Medicine, UFR Simone Veil, Université Versailles Saint-Quentin-en-Yvelines (Paris Saclay University), Paris, France.

Objective: To investigate the feasibility and the outcomes of transoral laser CO microsurgery (TLM) for resection of early-stage squamous cell carcinoma (SCC) of the vocal folds through several additional surgical procedures and tips improving the glottic exposure.

Methods: Retrospective chart review of patients treated by TLM cordectomy in a single European University Hospital for early-stage vocal fold SCCs (Tis, T1a, T1b, and T2). The following TLM outcomes were studied regarding the tumor size (Tis and T1a vs T1b and T2) and the margin status (negative vs positive/suspicious): patient position; type of laryngoscope; requirement to external counter pressure; resection of supraglottic structures (eg, ventricular band, epiglottic petiole, and suprahyoid epiglottis); pre- and postoperative complications; overall survival; disease-specific survival (DSS); and disease-free survival (DFS). Read More

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http://dx.doi.org/10.1177/0145561320911486DOI Listing

Evone® Flow-Controlled Ventilation During Upper Airway Surgery: A Clinical Feasibility Study and Safety Assessment.

Front Surg 2020 28;7. Epub 2020 Feb 28.

Otorhinolaryngology, Head and Neck Surgery, University Hospitals Leuven, Leuven, Belgium.

During upper airway surgery in a narrowed airway due to tumor or stenosis, safe ventilation, good laryngotracheal exposure, and preservation of an adequate surgical working space are of paramount importance. This can be achieved by small-lumen ventilation such as High Frequency Jet Ventilation (HFJV). However, this technique has major drawbacks, such as air-trapping and desaturation in patients with poor pulmonary reserve. Read More

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http://dx.doi.org/10.3389/fsurg.2020.00006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7058692PMC
February 2020

The diagnostic value of perpendicular vascular patterns of vocal cords defined by narrow-band imaging.

Eur Arch Otorhinolaryngol 2020 Jun 28;277(6):1715-1723. Epub 2020 Feb 28.

University Department of Otorhinolaryngology and Cervicofacial Surgery, University Medical Centre Ljubljana, Zaloška 2, 1000, Ljubljana, Slovenia.

Purpose: According to the classification of glottic lesions by narrow-band imaging (NBI) proposed by the European Laryngological Society (ELS), lesions without perpendicular patterns are benign, while wide- and narrow-angled perpendicular lesions include both papilloma and carcinoma/high-grade lesions, respectively. The purpose of the study was to investigate the effectiveness of the ELS classification.

Methods: One hundred and forty four patients with glottic lesions underwent microlaryngoscopy with NBI. Read More

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http://dx.doi.org/10.1007/s00405-020-05864-5DOI Listing

Dose Reduction to the Swallowing Apparatus and the Salivary Glands by De-Intensification of Postoperative Radiotherapy in Patients with Head and Neck Cancer: First (Treatment Planning) Results of the Prospective Multicenter DIREKHT Trial.

Cancers (Basel) 2020 Feb 26;12(3). Epub 2020 Feb 26.

Department of Radiation Oncology, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), 91054 Erlangen, Germany.

Aim: Evaluating radiotherapy treatment plans of the prospective DIREKHT trial (ClinicalTrials.gov, NCT02528955) investigating de-intensification of radiotherapy in patients with head and neck cancer.

Patients And Methods: The first 30 patients from the DIREKHT trial of the leading study centre were included in this analysis. Read More

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http://dx.doi.org/10.3390/cancers12030538DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7139715PMC
February 2020

Imaging checklist for preoperative evaluation of laryngeal tumors to be treated by transoral microsurgery: guidelines from the European Laryngological Society.

Eur Arch Otorhinolaryngol 2020 Jun 27;277(6):1707-1714. Epub 2020 Feb 27.

Department of Otorhinolaryngology, Maxillofacial and Thyroid Surgery, Fondazione IRCCS, National Cancer Institute of Milan, University of Milan, Milan, Italy.

Introduction: The modern availability in daily practice of different DICOM viewers allows physicians to routinely evaluate computed tomography (CT) and magnetic resonance (MR) scans of patients in the pre-, intra-, and postoperative settings. Their systematic use, together with a close surgeon-radiologist cooperation, may greatly improve outcomes of patients to be treated by transoral microsurgery for laryngeal cancer.

Materials And Methods: We herein propose guidelines for systematic evaluation of CT/MR images taken from patients affected by supraglottic and glottic cancer to be treated by transoral microsurgery. Read More

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http://dx.doi.org/10.1007/s00405-020-05869-0DOI Listing

[Voice analysis of early glottic carcinoma treated by carbon dioxide laser].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2020 Feb;34(2):162-165

Department of Otolaryngology Head and Neck Surgery,Beijing Tongren Hospital,Capital Medical University,Key Laboratory of Otolaryngology Head and Neck Surgery(Capital Medical University),Ministry of Education,Beijing,100730,China.

The aim of this study is to investigate the effect of CO2 laser cordectomy on the voice of early glottic carcinoma. A retrospective analysis of 40 patients who underwent CO2 laser treatment early glottis preoperative clinical data of postoperative laryngeal cancer patients, patients with postoperative recurrence rate, survival rate, and the postoperative complications of patients with preoperative and postoperative laryngoscopy, voice disorders index(voice handicap index, VHI) simplified Chinese version(VHI 13) rating scale, affecting the stability sound quality postoperatively in patients with laryngeal cancer were discussed. All patients underwent voice reexamination 8-97 months after surgery, and the survival rate was 100%, no local recurrence and no obvious postoperative complications. Read More

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http://dx.doi.org/10.13201/j.issn.1001-1781.2020.02.015DOI Listing
February 2020

Oncological and functional outcomes after repeat transoral laser microsurgery for the treatment of recurrent early glottic cancer.

J Laryngol Otol 2020 Feb 21:1-5. Epub 2020 Feb 21.

Division of Otolaryngology - Head and Neck Surgery, Department of Surgery, Dalhousie University, Halifax, Canada.

Background: Transoral laser microsurgery for glottic squamous cell carcinoma is the standard of care at many institutions. Repeat transoral laser microsurgery for recurrence may avoid the need for radiotherapy and total laryngectomy. This study aimed to identify oncological and functional outcomes in a cohort of patients who had undergone repeat transoral laser microsurgery procedures. Read More

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http://dx.doi.org/10.1017/S0022215120000407DOI Listing
February 2020

Multidimensional Voice Quality Evaluation After Transoral CO Laser Cordectomy: A Prospective Study.

Ear Nose Throat J 2020 Feb 18:145561320906328. Epub 2020 Feb 18.

Department of Otolaryngology-Head and Neck Surgery, Foch Hospital, School of Medicine, UFR Simone Veil, Université Versailles Saint-Quentin-en-Yvelines (Paris Saclay University), Paris, France.

Objective: To investigate voice quality changes of patients treated by transoral laser cordectomy (TLC) for early glottic cancer according to the type of cordectomies.

Methods: A total of 164 consecutive male patients with an early glottic cancer were prospectively recruited from the Department of Otolaryngology-Head and Neck Surgery of the Georges Pompidou European Hospital. Depending on the tumor characteristics, patients benefited from type I to VI CO cordectomy regarding the European Laryngological Society classification. Read More

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http://dx.doi.org/10.1177/0145561320906328DOI Listing
February 2020

[EARLY LARYNGEAL CANCER - TREATMENT OUTCOMES OF TRANSORAL LASER MICROSURGERY].

Harefuah 2020 Feb;159(1):77-82

Department of Otolaryngology Head and Neck Surgery, Carmel Medical Center, Haifa, Israel.

Aims: To evaluate predictive factors for local control, larynx preservation and overall survival in patients with early laryngeal cancer, who were treated with endoscopic transoral CO2 laser microsurgery.

Background: Transoral laser microsurgery (TLM) is the treatment of choice for early laryngeal cancer. The current study aimed to assess the outcomes and validity of carbon dioxide (CO2) laser microsurgery in patients with early larynx cancer and to determine predictors for outcomes. Read More

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February 2020

Surgical nodal management in hypopharyngeal and laryngeal cancer.

Eur Arch Otorhinolaryngol 2020 May 11;277(5):1481-1489. Epub 2020 Feb 11.

Department of Otorhinolaryngology-Head and Neck Surgery, University Medical Centre Freiburg, Killianstrasse 5, 79106, Freiburg, Germany.

Objective: The aim of this study is to compare pre-therapeutic staging of the loco-regional lymphatic basin and subsequent surgical management in cN0 versus cN+ hypopharyngeal and laryngeal cancer patients.

Methods: We analyzed all hypopharyngeal and laryngeal carcinoma patients treated surgically at a single quaternary medical care and cancer center between 2004 and 2014. We established two groups for patients who underwent neck dissection comparing patients with a low LNR (lymph node ratio) to one with a high LNR. Read More

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http://dx.doi.org/10.1007/s00405-020-05838-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7160213PMC

Efficacy and safety of accelerated fractionated radiotherapy without elective nodal irradiation for T3N0 glottic cancer without vocal cord fixation.

Head Neck 2020 Feb 7. Epub 2020 Feb 7.

Department of Radiation Oncology, National Cancer Center Hospital East, Chiba, Japan.

Background: The purpose of this study was to evaluate accelerated fractionated radiotherapy (AFRT) without elective nodal irradiation (ENI) for T3N0 glottic cancer (GC) without vocal cord fixation, especially in comparison with chemoradiotherapy (CRT) and hyperfractionated radiotherapy (HFRT) both of which included ENI.

Methods: The medical charts of patients with T3N0GC without cord fixation received definitive radiotherapy between June 2005 and March 2018 were reviewed.

Results: A total of 74 patients were analyzed. Read More

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http://dx.doi.org/10.1002/hed.26092DOI Listing
February 2020
2.641 Impact Factor

Management of a glottic squamous cell carcinoma with cutaneous metastasis.

J Oncol Pharm Pract 2020 Feb 6:1078155219900782. Epub 2020 Feb 6.

Medical Oncology, Muğla Sıtkı Koçman University School of Medicine, Muğla, Turkey.

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http://dx.doi.org/10.1177/1078155219900782DOI Listing
February 2020

Phonatory compensation in patients with larynx cancer after CO2 laser cordectomy.

Otolaryngol Pol 2019 Oct;74(2):31-35

Zakład Fonoaudiologii Klinicznej i Logopedii, Uniwersytet Medyczny w Białymstoku.

Introduction: CO2 laser endoscopic cordectomy is the method of laryngeal cancer treatment. The type of cordectomy (I-VI) depends on the extent of the tumor. Endoscopic laser surgery provides more satisfactory phonation conditions in comparison to open surgical procedures. Read More

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http://dx.doi.org/10.5604/01.3001.0013.5260DOI Listing
October 2019

Medication treatment of singultus in palliative care.

Cas Lek Cesk 2019 ;158(7-8):306-309

Singultus (hiccup) is caused by periodic involuntary spastic contractions of the respiratory muscles followed by a sharp inspiration and early glottis closure. This results in typical "hic" sound. Brief episodes of hiccups are quite common experience in general population, and they do not indicate serious disease nor require medical treatment. Read More

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February 2020

Fractionation scheme and treatment planning method for early glottic cancer in the United States: Economic impact of different medical decisions.

Head Neck 2020 Jan 24. Epub 2020 Jan 24.

Institute of Oncology, Davidoff Cancer Center, Rabin Medical Center, Israel.

Background: Early glottic cancers are often treated with radiotherapy (RT). We assessed the economic impact of fractionation scheme and planning method for payers in the United States.

Methods: A population-based analysis of the total cost of RT for early glottic cancers in the United States was performed annually. Read More

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http://dx.doi.org/10.1002/hed.26082DOI Listing
January 2020

Hoarseness of Voice as a Rare Presentation of Tuberculosis: A Case Report Study.

Open Access Maced J Med Sci 2019 Oct 11;7(19):3262-3264. Epub 2019 Oct 11.

Department of Surgery, Otorhinolaryngology section, King Fahad General Hospital, Jeddah 23325, Kingdom of Saudi Arabia.

Background: Having hoarseness of voice as the first clinical manifestation of tuberculosis is rare. This atypical presentation causes some confusion since other more common conditions, such as laryngeal carcinoma, present similarly and might require more invasive tests to confirm the diagnosis.

Case Presentation: A 38-year-old male presented to the otorhinolaryngology clinic with a four-month history of change in voice. Read More

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http://dx.doi.org/10.3889/oamjms.2019.817DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6953943PMC
October 2019

Intensity-modulated radiotherapy for stage I glottic cancer: a short-term outcomes compared with three-dimensional conformal radiotherapy.

Radiat Oncol J 2019 Dec 31;37(4):271-278. Epub 2019 Dec 31.

Department of Otorhinolaryngology-Head and Neck Surgery, Chonnam National University Hwasun Hospital, Chonnam National University Medical School, Hwasun, Korea.

Purpose: To investigate the differences in treatment outcomes between two radiation techniques, intensity-modulated radiotherapy (IMRT) and three-dimensional conformal radiotherapy (3DCRT).

Materials And Methods: We retrospectively analyzed 160 (IMRT = 23, 3DCRT = 137) patients with stage I glottic cancer treated from January 2005 through December 2016. The IMRT was performed with TomoTherapy (16 patients), volumetric-modulated arc therapy (6 patients), and step-and-shoot technique (1 patient), respectively. Read More

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http://dx.doi.org/10.3857/roj.2019.00283DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6952717PMC
December 2019

[The progress of narrow band imaging endoscopy in diagnosis of vocal cord leukoplakia].

Authors:
B G Zhang X G Ni

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2019 Nov;33(11):1113-1116

The appearances of vocal cord leukoplakia are largely identical in the macroscopic examination even though the pathological character may differ. This makes it difficult for physicians to evaluate the extent of dysplasia of vocal cord leukoplakia and detect the occurrence of canceration using the conventional laryngoscopy, which might result in overtreatment or undertreatment of vocal cord leukoplakia in different patients. Therefore, an accurate preoperative assessment of the pathological character of vocal cord leukoplakia shows clinical significance in the selection of an appropriate treatment plan and predicting the prognosis of a patient. Read More

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http://dx.doi.org/10.13201/j.issn.1001-1781.2019.11.027DOI Listing
November 2019

[Vocal cords myxoma misdiagnosed as vocal cord polyp:a case report].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2019 Dec;33(12):1206-1206;1208

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http://dx.doi.org/10.13201/j.issn.1001-1781.2019.12.022DOI Listing
December 2019

Assessment of HPV 16, HPV 18, p16 expression in advanced stage laryngeal cancer patients and prognostic significance.

Braz J Otorhinolaryngol 2019 Dec 12. Epub 2019 Dec 12.

Cukurova University School of Medicine, Department of Otorhinolaryngology Head & Neck Surgery, Adana, Turkey.

Introduction: Human papilloma virus is an etiological risk factor for a subset of head and neck squamous cell carcinomas. HPV has been proven to be a powerful prognostic biomarker for oropharyngeal cancer, but its role in the larynx has not been explored in depth. The developmental mechanisms of laryngeal carcinomas are quite complex and controlled by various factors. Read More

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http://dx.doi.org/10.1016/j.bjorl.2019.11.005DOI Listing
December 2019

MACC1 expression is an indicator of recurrence in early-stage glottic cancer.

Jpn J Clin Oncol 2020 Apr;50(4):392-398

Division of Pathophysiology, Okayama University Graduate School of Health Sciences, Okayama, Japan.

Background: Metastasis-associated in colon cancer 1 (MACC1) has been reported to be an independent indicator of poor prognoses in some kinds of cancer due to disease metastasis or recurrence. We investigated the correlation between MACC1 expression and the prognosis of glottic cancer.

Methods: Paraffin-embedded, early-stage (I or II) glottic cancer specimens (n = 52) were immunohistochemically analyzed to explore MACC1 expression. Read More

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http://dx.doi.org/10.1093/jjco/hyz206DOI Listing

Feasibility of single vocal cord irradiation as a treatment strategy for T1a glottic cancer.

Head Neck 2020 May 19;42(5):854-859. Epub 2019 Dec 19.

Department of Radiation Oncology, Yonsei Cancer Center, Yonsei University College of Medicine, Seoul, South Korea.

Background: Generally, radiotherapy for patients with early glottic cancer includes treatment of the whole larynx. This study was conducted to evaluate the treatment outcomes and toxicity in patients who received single vocal cord irradiation (SVCI) for T1a classification glottic cancer.

Methods: A total of 34 patients diagnosed with clinical T1aN0M0 classification squamous cell carcinoma of the glottis who received radiotherapy to the single vocal cord were included for analysis. Read More

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http://dx.doi.org/10.1002/hed.26052DOI Listing

Unique Patterns of Distant Metastases in HPV-Positive Head and Neck Cancer.

Oncology 2020 17;98(3):179-185. Epub 2019 Dec 17.

Division of Hematology and Oncology, UT Southwestern Medical Center, Dallas and Harold C. Simmons Comprehensive Cancer Center, Dallas, Texas, USA,

Background: HPV-positive head and neck squamous cell carcinoma (HPV+ HNSCC) demonstrates favorable outcomes compared to HPV-negative SCC, but distant metastases (DM) still occur. The pattern of DM in HPV+ HNSCC is unclear.

Methods: 1,494 HNSCC patients were treated from 2006 to 2012. Read More

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http://dx.doi.org/10.1159/000504651DOI Listing

Patterns of Care and Outcomes of Intensity-Modulated Radiotherapy and 3D Conformal Radiotherapy for Early Stage Glottic Cancer: A National Cancer Database Analysis.

Cancers (Basel) 2019 Dec 12;11(12). Epub 2019 Dec 12.

Department of Radiation and Cellular Oncology, University of Chicago Medical Center, Chicago, IL 60637, USA.

Early stage glottic cancer has traditionally been treated with 3D conformal radiotherapy (3DCRT). However, intensity-modulated radiotherapy (IMRT) has been recently adopted as an alternative to decrease toxicity. Here, we compared the usage and outcomes of IMRT and 3DCRT for patients with early stage squamous cell carcinoma (SCC) of the glottic larynx. Read More

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http://dx.doi.org/10.3390/cancers11121996DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6966448PMC
December 2019

High serum CCL18 predicts a poor prognosis in patients with laryngeal squamous cell carcinoma.

J Cancer 2019 17;10(27):6910-6914. Epub 2019 Nov 17.

Department of Otolaryngology Head and Neck Surgery, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, Hunan 410008, People's Republic of China.

CCL18 is a cytokine secreted by M2 type tumor associated macrophages, which frequently over-expressed in diverse human cancers. However, the clinical significance of serum CCL18 in patients with laryngeal squamous cell carcinoma (LSCC) remains unknown. In this study, serum CCL18 was initially quantified by enzyme-linked immunosorbent assay (ELISA) in 146 patients with LSCC, 25 patients with precancerous lesions and 72 healthy volunteers. Read More

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http://dx.doi.org/10.7150/jca.37515DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6909940PMC
November 2019

Prognostic significance of surgical margins after transoral laser microsurgery for early-stage glottic cancer.

Oral Oncol 2020 01 10;100:104511. Epub 2019 Dec 10.

Head and Neck Services, Tata Memorial Hospital, Dr E Borges Road, Parel, Mumbai 400012, India; Homi Bhabha National Institute, Mumbai, India.

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http://dx.doi.org/10.1016/j.oraloncology.2019.104511DOI Listing
January 2020

CO Laser Cordectomy Versus KTP Laser Tumor Ablation for Early Glottic Cancer: A Randomized Controlled Trial.

Lasers Surg Med 2019 Dec 11. Epub 2019 Dec 11.

Department of Otolaryngology Head and Neck Surgery, Rabin Medical Center, 39 Ze'ev Jabotinski St, Petach-Tikva, 4941492, Israel.

Background And Objectives: CO laser cordectomy has been the workhorse of laser surgery for early glottic squamous cell carcinoma (GSCC) since the early 1970s. During the last decades, potassium titanyl phosphate (KTP) laser surgery for early GSCC gained popularity, introducing the tumor ablation technique. Yet, there are no previous randomized controlled trials (RCT) that compare the oncologic and functional outcomes of KTP Laser ablation versus CO laser cordectomy for early GSCC. Read More

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http://dx.doi.org/10.1002/lsm.23202DOI Listing
December 2019

Comparison of Voice Quality of Life in Early Stage Glottic Carcinoma Treated with Endoscopic Cordectomy Using Radiofrequency Microdissection Electrodes, Laser Cordectomy, and Radiotherapy.

J Voice 2019 Nov 26. Epub 2019 Nov 26.

Department of Otorhinolaryngology-Head and Neck Surgery, Pendik Training and Research Hospital, Marmara University Medical Faculty, Istanbul, Turkey.

Purpose: To compare the quality of life of patients with early glottic carcinoma who have been treated using three treatment modalities: endoscopic cordectomy using radiofrequency microdissection electrodes (ECRM), transoral laser cordectomy, and radiotherapy (RT). ECRM, transoral laser cordectomy, and RT can all be used as alternatives to invasive open surgery to treat the early stages of glottic cancer such as stage T1. Patients treated using these different modalities could have different outcomes with respect to voice quality of life. Read More

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http://dx.doi.org/10.1016/j.jvoice.2019.11.003DOI Listing
November 2019

Conservative Curative Larynx Preserving Surgery for Subglottic Soft Tissue Recurrence Reinforced with Fascia-Lata and Strap Muscles.

Indian J Otolaryngol Head Neck Surg 2019 Oct 13;71(Suppl 1):737-739. Epub 2018 Nov 13.

Department of Head and Neck Oncology, HCG Cancer Centre, Ahmedabad, Gujarat 380060 India.

For early cancers of vocal cords, trans oral laryngeal surgery (TOLS) and curative radiotherapy (RT), have remained mainstay of treatment. Soft tissue recurrence in laryngeal cancers is not much documented, leading to absence of guidelines to deal with it, salvage total laryngectomy being the treatment of choice. We present a tailormade surgical procedure for limited soft tissue recurrence of glottic cancer extending into subglottic anterior soft tissue reinforced with fascia lata and strap muscles, previously treated with TOLS and/or RT. Read More

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http://dx.doi.org/10.1007/s12070-018-1531-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6848570PMC
October 2019

Oncological Outcomes Following Transoral CO Laser Microsurgery for T1 Glottic Cancer.

Indian J Otolaryngol Head Neck Surg 2019 Oct 14;71(Suppl 1):542-547. Epub 2018 May 14.

Department of Otorhinolaryngology and Head & Neck Surgery, University College of Medical Sciences and Guru Teg Bahadur Hospital, Delhi, 110095 India.

The objective of this study is to analyze oncological outcomes for treatment of Tis and T1 glottic squamous cell carcinoma after transoral laser microsurgery. This study is retrospective analysis of previously untreated, suspected lesion of glottis, staged cT1a and cT1b squamous cell carcinoma in a tertiary care hospital and 53 patients were included in the study. End points for analysis were local control, overall and disease specific survival rates. Read More

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http://dx.doi.org/10.1007/s12070-018-1394-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6848340PMC
October 2019

Learned and handcrafted features for early-stage laryngeal SCC diagnosis.

Med Biol Eng Comput 2019 Dec 14;57(12):2683-2692. Epub 2019 Nov 14.

Department of Information Engineering, Universitá Politecnica delle Marche, Ancona, Italy.

Squamous cell carcinoma (SCC) is the most common and malignant laryngeal cancer. An early-stage diagnosis is of crucial importance to lower patient mortality and preserve both the laryngeal anatomy and vocal-fold function. However, this may be challenging as the initial larynx modifications, mainly concerning the mucosa vascular tree and the epithelium texture and color, are small and can pass unnoticed to the human eye. Read More

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http://dx.doi.org/10.1007/s11517-019-02051-5DOI Listing
December 2019

Mapping of sentinel lymph node drainage using SPECT/CT to tailor elective nodal irradiation in head and neck cancer patients (SUSPECT-2): a single-center prospective trial.

BMC Cancer 2019 Nov 14;19(1):1110. Epub 2019 Nov 14.

Department of Radiation Oncology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066, CX, Amsterdam, The Netherlands.

Background: The majority of patients with head and neck squamous cell carcinoma (HNSCC) receive bilateral elective nodal irradiation (ENI), in order to reduce the risk of regional failure. Bilateral ENI, as compared to unilateral ENI, is associated with higher incidence of acute and late radiation-induced toxicity with subsequent deterioration of quality of life. Increasing evidence that the incidence of contralateral regional failure (cRF) in lateralized HNSCC is very low (< 10%) suggests that it can be justified to treat selected patients unilaterally. Read More

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http://dx.doi.org/10.1186/s12885-019-6331-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6857144PMC
November 2019

The prognostic value of anterior commissure involvement in T1 glottic cancer: A systematic review and meta-analysis.

Laryngoscope 2019 Nov 13. Epub 2019 Nov 13.

Department of Otolaryngology-Head and Neck Surgery, Scientific Institutes of Hospitalization and Care San Raffaele Hospital, Vita-Salute University, Milan, Italy.

Objective: The anterior commissure is considered a laryngeal subsite, but it is not taken into account in the current T-staging system. The impact of anterior commissure involvement (ACI) on the oncologic outcomes of T1 glottic tumors has not been well defined and remains controversial. The aim of this study was to assess the influence of ACI in the prognosis of T1 glottic tumors. Read More

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http://dx.doi.org/10.1002/lary.28395DOI Listing
November 2019

Intravascular Papillary Endothelial Hyperplasia of the Vocal Cord: A Case Report and Review of the Literature.

Am J Case Rep 2019 Nov 12;20:1664-1668. Epub 2019 Nov 12.

Otorhinolaryngology-Head and Neck Surgery, Haeundae Paik Hospital, Inje University, College of Medicine, Busan, South Korea.

BACKGROUND Intravascular papillary endothelial hyperplasia (IPEH), is a vascular tumor characterized by the proliferation of endothelial cells with papillary formations. It is a rare benign disease; therefore, it is important to exclude malignant vascular neoplasm in order to prevent misdiagnosis and inappropriate overtreatment. CASE REPORT Herein, we describe the case of a 51-year-old male who reported changes in his voice, and who was preoperatively diagnosed with vocal cord polyp and hemorrhagic change based on laryngoscopy. Read More

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http://dx.doi.org/10.12659/AJCR.920181DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6859931PMC
November 2019

Treatment of a stage III rima glottidis patient with the oncolytic virus Rigvir: A retrospective case report.

Medicine (Baltimore) 2019 Nov;98(45):e17883

Rigvir.

Rationale: Of all the parts of the larynx, the glottis has the highest frequency of cancer. With disease progression, the vocal cord movement is affected and for advanced stages its anatomical and functional preservation is rarely achievable, if at all.

Patient Concerns: Here we describe a 72-year-old patient who presented with hoarseness for a year and was only able to whisper. Read More

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http://dx.doi.org/10.1097/MD.0000000000017883DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6855627PMC
November 2019
5.723 Impact Factor

Functional Results after Larynx-Preserving Treatment of Laryngeal Cancer. Suggestions for follow-up.

Otolaryngol Pol 2019 Jun;73(5):31-36

Wydział Otolaryngologii i Chirurgii Głowy i Szyi, Uniwersytet Komeńskiego w Bratysławie, Słowacja.

ntroduction: Laryngeal cancer and its treatment are associated with both short- and long-term side effects, affecting laryngeal functions and having an impact on the quality of life. Material and methods: Retrospective analysis of the medical records of patients receiving surgical or non-surgical, larynx- -preserving treatment for laryngeal cancer. R esults: After termination of the treatment, the highest proportion of patients with bad voice quality was in the glottic carcinoma group (both in early and late phase), with swallowing dysfunction in the transglottic carcinoma group. Read More

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http://dx.doi.org/10.5604/01.3001.0013.2310DOI Listing