5,564 results match your criteria Glottic Cancer


Radiation Therapy Impact on Lymph Node Yield in Patients With Laryngeal Squamous Cell Carcinoma.

Ear Nose Throat J 2019 Apr 8:145561319839790. Epub 2019 Apr 8.

1 Department of Otolaryngology-Head and Neck Surgery, Augusta University, Augusta, GA, USA.

Background: A lymph node yield (LNY) over 20 is considered a quality metric for lateral neck dissection to ensure an oncologic representative sample. Anecdotally, however, LNY in patients undergoing neck dissection after radiation therapy (RT) is lower due to atrophy and fibrosis.

Objective: To determine whether preoperative RT decreases LNY in patients with laryngeal cancers undergoing surgery. Read More

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http://dx.doi.org/10.1177/0145561319839790DOI Listing
April 2019
7 Reads

Perceptual and Acoustic Outcomes of Early-Stage Glottic Cancer After Laser Surgery or Radiotherapy: A Meta-Analysis.

Clin Exp Otorhinolaryngol 2019 Apr 9. Epub 2019 Apr 9.

Department of Otolaryngology-Head and Neck Surgery, Chonbuk National University-Chonbuk National University Hospital, Jeonju, Korea.

Objectives: Laser surgery (LS) or radiotherapy (RT) is normally recommended in early glottic cancer. The objective of this study was to perform a comprehensive meta-analysis of acoustic and perceptual outcomes to compare voice quality of LS or RT in early-stage glottic cancer.

Methods: Data sources were obtained after searching PubMed, Google Scholar, EBSCO, and RISS using the following search terms: glottic cancer, glottic carcinoma, endoscopic surgery, laser surgery, radiotherapy, radiation, voice, voice quality, and grade, roughness, breathiness, asthenia, and strain (GRBAS) scale. Read More

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http://dx.doi.org/10.21053/ceo.2018.00990DOI Listing
April 2019
1 Read

Prospective validation of an institutional treatment strategy for T1N0M0 glottic carcinoma.

Eur J Surg Oncol 2019 Mar 27. Epub 2019 Mar 27.

Department of Head & Neck Surgery, St Luc University Hospital and King Albert II Cancer Institute, Brussels, Belgium; Institut de Recherche Expérimentale et Clinique (IREC), Université Catholique de Louvain, Brussels, Belgium.

Introduction: The aim of this study was to assess the validity of a treatment strategy for T1N0 glottic squamous cell carcinoma.

Methods: One hundred and seventeen patients were prospectively treated according to institutional guidelines. using 1) laser microsurgery (L) for exophytic tumor, limited to one vocal cord, without extension to the anterior commissure or the vocal process of the arytenoid cartilage, 2) radiotherapy (RT) for large or infiltrative tumor reaching the anterior commissure or the vocal process of the arytenoid cartilage, poor endoscopic exposure and cT1b or 3) partial laryngectomy (PL) for tumor infiltrating the anterior commissure. Read More

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http://dx.doi.org/10.1016/j.ejso.2019.03.032DOI Listing
March 2019
5 Reads

Dosimetric comparison of intensity-modulated radiation therapy for early-stage glottic cancers with and without the air cavity in the planning target volume.

Med Dosim 2019 Mar 27. Epub 2019 Mar 27.

Department of Radiation Oncology, University of Miami/Sylvester Comprehensive Cancer Center, Miami, FL 33136, USA. Electronic address:

For early-stage glottic cancers, intensity-modulated radiation therapy (IMRT) has been shown to have comparable local control to 3D-conformal radiotherapy with the advantage of decreased dose to the carotid arteries. The planning target volume (PTV) for early glottic cancers typically includes the entire larynx, plus a 3 to 5 mm uniform margin. The air cavity within the larynx creates a challenge for the inverse optimization process as the software attempts to "build up" dose within the air. Read More

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http://dx.doi.org/10.1016/j.meddos.2019.02.007DOI Listing
March 2019
1 Read

Longitudinal analysis of Voice Handicap Index in early glottic cancer patients treated with transoral laser microsurgery: age, gender, stage and time dependence.

J Laryngol Otol 2019 Mar 29:1-6. Epub 2019 Mar 29.

Division of Otolaryngology - Head and Neck Surgery,Queen Elizabeth II Health Sciences Centre and Dalhousie University,Halifax,Canada.

Objectives: Transoral laser microsurgery is an increasingly common treatment modality for glottic carcinoma. This study aimed to determine the effect of age, gender, stage and time on voice-related quality of life using the Voice Handicap Index-10.

Methods: Primary early glottic carcinoma patients treated with transoral laser microsurgery were included in the study. Read More

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http://dx.doi.org/10.1017/S0022215119000392DOI Listing

Autologous Fat Augmentation in Post Type III Cordectomy Patients.

Indian J Otolaryngol Head Neck Surg 2019 Mar 30;71(1):38-41. Epub 2018 Nov 30.

Voice Clinic, Deenanath Mangeshkar Hospital, Superspeciality Building 1st Floor, Erandwane, Pune, 411004 India.

Neocord formation after Type III cordectomy is insufficient for complete glottic closure due to scarring and soft tissue deficit. This study evaluates the role of autologous fat injection (AFI) in phonosurgical management of patients who have previously undergone Type III cordectomy for early glottic cancer. Data was collected from hospital records of patients who underwent AFI after previously undergoing Type III cordectomy. Read More

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http://link.springer.com/10.1007/s12070-018-1543-9
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http://dx.doi.org/10.1007/s12070-018-1543-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6401367PMC
March 2019
8 Reads

Dose-volume relationship for laryngeal substructures and aspiration in patients with locally advanced head-and-neck cancer.

Radiat Oncol 2019 Mar 18;14(1):49. Epub 2019 Mar 18.

Department of Radiation Oncology, Northwestern University, Chicago, IL, USA.

Background: Literature has shown a significant relationship between radiation dose to the larynx and swallowing disorders. We prospectively studied the dose-volume relationship for larynx substructures and aspiration.

Methods: Forty nine patients with stage III/IV head-and-neck (H&N) squamous cell carcinoma were prospectively enrolled in this IRB-approved, federally funded study. Read More

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http://dx.doi.org/10.1186/s13014-019-1247-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6423881PMC
March 2019
1 Read

Primary poorly differentiated small cell type neuroendocrine carcinoma of the hypopharynx.

Onco Targets Ther 2019 27;12:1593-1601. Epub 2019 Feb 27.

Department of Otolaryngology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Zhejiang Province 310003, China,

The incidence of primary poorly differentiated neuroendocrine carcinoma (PDNC) of the hypopharynx iŝ4%. However, the disease pathogenesis, natural history, and prognostic factors remain poorly understood. We report the case of a 66-year-old man who presented with multiple metastases from primary PDNC of the hypopharynx. Read More

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http://dx.doi.org/10.2147/OTT.S189241DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6398402PMC
February 2019
1 Read

Early Closure of a Phase 1 Clinical Trial for SABR in Early-Stage Glottic Cancer.

Int J Radiat Oncol Biol Phys 2019 Mar 14. Epub 2019 Mar 14.

Department of Radiation Oncology, Seoul National University College of Medicine, Seoul, Republic of Korea; Cancer Research Institution, Seoul National University College of Medicine, Seoul, Republic of Korea; Institute of Radiation Medicine, Medical Research Center, Seoul National University, Seoul, Republic of Korea. Electronic address:

Purpose: The early results of a phase 1 study of stereotactic ablative radiation therapy for early-stage glottis cancer were previously reported. However, additional late adverse events occurred in the second arm during the follow-up period. In this study, the dose-limiting toxicities and premature closure of the clinical trial are reported. Read More

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http://dx.doi.org/10.1016/j.ijrobp.2019.03.011DOI Listing
March 2019
2 Reads
4.258 Impact Factor

Phase 1 Fractional Dose-Escalation Study of Equipotent Stereotactic Radiation Therapy Regimens for Early-Stage Glottic Larynx Cancer.

Int J Radiat Oncol Biol Phys 2019 Mar 14. Epub 2019 Mar 14.

Department of Otolaryngology-Head and Neck Surgery, University of Texas Southwestern Medical Center, Dallas, Texas.

Purpose: Early-stage glottic larynx squamous cell carcinoma (GLC) is a relatively common disease with excellent oncologic control, but treatment is associated with acute dysphagia and long-term voice quality changes. This phase 1 study of hypofractionated radiation therapy for early-stage GLC increased the fraction size while reducing the number of fractions until 5-fraction stereotactic ablative radiation therapy (SABR) was delivered.

Methods And Materials: Eligible patients had received a diagnosis of stage Tis to T2 GLC. Read More

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http://dx.doi.org/10.1016/j.ijrobp.2019.03.010DOI Listing
March 2019
6 Reads

Arytenoid Fixation in Laryngeal Cancer: Radiological Pictures and Clinical Correlations with Respect to Conservative Treatments.

Cancers (Basel) 2019 Mar 13;11(3). Epub 2019 Mar 13.

Head and Neck Oncology Service, Candiolo Cancer Institute-FPO IRCCS, 10060 Candiolo (TO), Italy.

The aim of this retrospective study was to identify different radiological features in intermediate⁻advanced laryngeal cancer (LC) associated with arytenoid fixation, in order to differentiate cases still safely amenable to conservative treatment by partial laryngectomy or chemoradiotherapy. : 29 consecutive patients who underwent open partial horizontal laryngectomies (OPHLs), induction chemotherapy followed by radiotherapy in the case of >50% response (IC + RT) or total laryngectomy were classified as: pattern I (supraglottic LC fixing the arytenoid due to weight effect), pattern II (glottic LC involving the posterior paraglottic space and spreading toward the crico-arytenoid joint and infraglottic extension <10 mm), pattern III (glottic-infraglottic LC involving the crico-arytenoid joint and infraglottic extension >10 mm) and pattern IV (transglottic and infraglottic LC with massive crico-arytenoid unit involvement, reaching the hypopharyngeal submucosa). All glottic cancers treated with surgery were studied by a cross sectional approach. Read More

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http://dx.doi.org/10.3390/cancers11030360DOI Listing
March 2019
1 Read

A Method for Reconstruction of Anterior Commissure Glottal Webs With Endoscopic Fibro-Mucosal Flaps.

Ann Otol Rhinol Laryngol 2019 Mar;128(3_suppl):82S-93S

1 Department of Surgery, Harvard Medical School, Boston, MA, USA.

Background:: Anterior-commissure (AC) cicatrization and web formation is a difficult problem that can result from a variety of clinical scenarios. An advancement-rotation flap utilizing papillomatous epithelium and subepithelial fibrous tissue has been previously described. For patients in whom there was not excessive redundant papillomatosis covering the AC web, including other clinical scenarios, a microlaryngoscopic procedure was designed to lengthen the glottal/subglottal aperture using substantial local fibro-mucosal tissue. Read More

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http://dx.doi.org/10.1177/0003489418820031DOI Listing
March 2019
6 Reads

Glottic Carcinoma in Young Patients.

Ann Otol Rhinol Laryngol 2019 Mar;128(3_suppl):25S-32S

3 Department of Surgery, Harvard Medical School, Boston, MA, USA.

Introduction:: Recent reported evidence indicates that vocal cord carcinoma is evolving similarly to oropharyngeal cancer with an increasing number of patients without a smoking history having human papillomavirus (HPV) disease. Observations also suggest that an increasing number of patients who present with glottic carcinoma are younger than has been reported in the past. Therefore, an investigation was done to examine the incidence of glottic carcinoma in patients 30 years old (y/o) or younger. Read More

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http://dx.doi.org/10.1177/0003489418818852DOI Listing
March 2019
1 Read

Microvascular density and hypoxia-inducible factor in intraepithelial vocal fold lesions.

Eur Arch Otorhinolaryngol 2019 Apr 6;276(4):1117-1125. Epub 2019 Mar 6.

Otolaryngology Department, Medical University of Warsaw, Warsaw, Poland.

Objective: The promotion of neovascularisation is a crucial aspect of carcinogenesis. The study evaluates the microvascular density (MVD) and expression of hypoxia-induced factor (HIF-1α) in hypertrophic vocal fold (VF) lesions of different histopathological states including non-dysplastic, low-grade, high-grade dysplasia and invasive glottic cancer.

Materials And Methods: Histological specimens collected from patients diagnosed and treated in a single centre with different histological grades were immunohistochemically stained with CD31, CD34 and HIF-1α. Read More

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http://dx.doi.org/10.1007/s00405-019-05355-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6426810PMC

The role of elective neck dissection for cT4aN0 glottic squamous cell carcinoma.

Jpn J Clin Oncol 2019 Mar 4. Epub 2019 Mar 4.

Department of Head and Neck Surgery, National Cancer Center Hospital East, Kashiwa, Chiba, Japan.

Objective: The indication for elective neck dissection for patients with clinically T4aN0 (cT4aN0) glottic cancer is not established. The objective of this study was to evaluate the role of elective neck dissection for patients with cT4aN0 glottic cancer.

Methods: We assessed patients with cT4aN0 laryngeal squamous cell carcinoma who underwent total laryngectomy between 1998 and 2014 and conducted a retrospective analysis. Read More

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http://dx.doi.org/10.1093/jjco/hyz022DOI Listing
March 2019
5 Reads

Open Partial Horizontal Laryngectomies for T3⁻T4 Laryngeal Cancer: Prognostic Impact of Anterior vs. Posterior Laryngeal Compartmentalization.

Cancers (Basel) 2019 Mar 1;11(3). Epub 2019 Mar 1.

Department of Otorhinolaryngology-Head and Neck Surgery, University of Brescia, Piazza Spedali Civili 1, 25123 Brescia, Italy.

Open partial horizontal laryngectomies (OPHLs) are well-established and oncologically safe procedures for intermediate⁻advanced laryngeal cancers (LC). T⁻N categories are well-known prognosticators: herein we tested if "anterior" vs. "posterior" tumor location (as defined in respect to the paraglottic space divided according to a plane passing through the arytenoid vocal process, perpendicular to the ipsilateral thyroid lamina) may represent an additional prognostic factor. Read More

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http://dx.doi.org/10.3390/cancers11030289DOI Listing
March 2019
5 Reads

Clinical value of (dedicated) 3 Tesla and 7 Tesla MRI for cT1 glottic carcinoma: A feasibility study.

Laryngoscope Investig Otolaryngol 2019 Feb 15;4(1):95-101. Epub 2019 Jan 15.

Department of Radiotherapy University Medical Center Utrecht Utrecht The Netherlands.

Objective: To assess the feasibility of the clinical use of 3 Tesla and 7 Tesla Magnetic Resonance Imaging for early (cT1) glottic carcinoma, including structural assessment of technical image quality and visibility of the tumor; and if feasible, to correlate MRI findings to routine diagnostics.

Methods: Prospective feasibility study. Twenty patients with primary clinical T1 glottic carcinoma underwent both routine clinical staging and CT. Read More

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http://dx.doi.org/10.1002/lio2.246DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6383319PMC
February 2019
3 Reads

Volumetric modulated arc therapy with robust optimization for larynx cancer.

Phys Med 2019 Feb 25;58:54-58. Epub 2019 Jan 25.

Hiroshima High-Precision Radiotherapy Cancer Center, Hiroshima, Japan; Department of Radiation Oncology, Institute of Biomedical & Health Science, Hiroshima University, Hiroshima, Japan.

Purpose: The aim of this study was to perform a comparison between robust optimization and planning target volume (PTV)-based optimization plans using volumetric modulated arc-therapy (VMAT) by evaluating perturbed doses induced by localization offsets for setup uncertainties in larynx cancer radiation therapy.

Methods: Ten patients with early-stage (T1-2N0) glottis carcinoma were selected. The clinical target volume (CTV), carotid arteries, and spinal cord were contoured by a radiation oncologist. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S11201797193001
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http://dx.doi.org/10.1016/j.ejmp.2019.01.012DOI Listing
February 2019
6 Reads

Incidence and survival of laryngeal cancer in Denmark: a nation-wide study from 1980 to 2014.

Acta Oncol 2019 Mar 1:1-6. Epub 2019 Mar 1.

a Department of Otorhinolaryngology, Head and Neck Surgery and Audiology , Rigshospitalet, University of Copenhagen , Copenhagen , Denmark.

Background: The purpose of this registry study was to evaluate trends in incidence and survival of laryngeal cancer in the Danish population from 1980 to 2014.

Methods: This study includes all patients with laryngeal cancer registered in the Danish Cancer Registry (DCR) in the period 1980-2014. The age-adjusted incidence rate (AAIR) per 100,000 and average annual percent change (AAPC) were calculated. Read More

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https://www.tandfonline.com/doi/full/10.1080/0284186X.2019.1
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http://dx.doi.org/10.1080/0284186X.2019.1572923DOI Listing
March 2019
4 Reads

Quality of life and voice outcome of patients treated with transoral CO laser microsurgery for early glottic carcinoma (T1-T2): a 2-year follow-up study.

Eur Arch Otorhinolaryngol 2019 Mar 27;276(3):805-814. Epub 2019 Feb 27.

Department of Otorhinolaryngology, Head and Neck Surgery, Leiden University Medical Center, Leiden, The Netherlands.

Purpose: Longitudinal studies in laryngeal cancer can provide clinicians information about short-term and long-term functional outcomes, like quality of life (QoL) and voice outcome. This information is important when counseling patients or choosing a primary treatment modality. The present study assessed long-term (2 years) QoL and voice outcome in patients with extended T1 and limited T2 glottic carcinoma treated with transoral CO laser microsurgery (TLM) (unilateral type III or bilateral type II resections). Read More

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http://link.springer.com/10.1007/s00405-019-05348-1
Publisher Site
http://dx.doi.org/10.1007/s00405-019-05348-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6411677PMC
March 2019
3 Reads

Implementation of the European Laryngological Society classification for pediatric benign laryngotracheal stenosis: a multicentric study.

Eur Arch Otorhinolaryngol 2019 Mar 22;276(3):785-792. Epub 2019 Feb 22.

Department of Otorhinolaryngology Head and Neck Surgery, Katharinenhospital, Kriegsbergstrasse 60, 70174, Stuttgart, Germany.

Purpose: The European Laryngological Society (ELS) has published a revised classification for benign laryngotracheal stenosis (LTS), based on their degree, longitudinal extension, and associated comorbidities. We retrospectively applied this classification to pediatric patients treated in four referral centers to assess its reliability in predicting surgical outcomes.

Methods: We included 191 pediatric LTS patients treated by segmental resection, restaged according to the degree of stenosis (I-IV according to Myer-Cotton grading system), number of subsites involved ("a" to "d" for 1-4 subsites among supraglottis, glottis, subglottis and trachea), and presence of systemic comorbidity ("+" sign). Read More

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http://dx.doi.org/10.1007/s00405-019-05353-4DOI Listing
March 2019
1 Read

Retrospective analysis of 659 laryngeal squamous cell carcinoma patients treated with open laryngeal function-preserving operations.

Acta Otolaryngol 2018 Nov;138(11):1043-1050

a Department of Otolaryngology , Eye Ear Nose and Throat Hospital, Fudan University , Shanghai , China.

Background: Open laryngeal function-preserving surgery is a common therapeutic strategy for Chinese laryngeal squamous cell carcinoma (LSCC) patients.

Objectives: To explore the fundamental clinical characteristics and survival prognostic factors of LSCC patients treated with open laryngeal function-preserving operations.

Material And Methods: about a total of 659 LSCC patients undergoing open laryngeal function-preserving operations were retrospectively reviewed. Read More

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http://dx.doi.org/10.1080/00016489.2018.1500711DOI Listing
November 2018
1 Read

Radiotherapy in advanced glottic laryngeal carcinoma in a patient with Wegener's granulomatosis: how much radiation dose is needed?

Onco Targets Ther 2019 23;12:753-757. Epub 2019 Jan 23.

Radiation Oncology Unit, San Giuseppe Moscati Hospital, Taranto, Italy,

Wegener's granulomatosis (WG) is an autoimmune disorder characterized by necrotizing granulomas involving mainly the upper-lower respiratory and renal tracts, albeit a potentially life-threatening involvement of other body parts is not rare. Furthermore, there are several reports accounting for an increased risk of solid malignancies due to the autoimmune disease per se, or the immunosuppressive therapies. Among treatments, radiotherapy could be a therapeutic option as proven by its use in typical WG lesions such as solitary granulomas or subglottic stenosis, successfully treated with low radiation dose. Read More

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http://dx.doi.org/10.2147/OTT.S182011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6352862PMC
January 2019
1 Read

Factors responsible for the development of carbon granuloma post transoral laser cordectomy.

Lasers Med Sci 2019 Feb 13. Epub 2019 Feb 13.

Bombay Hospital Voice and Swallowing Centre, 2nd floor, MRC, Bombay Hospital & Medical Research Centre, 12 New Marine Lines, Mumbai, Maharashtra, 400020, India.

Our study was performed with an aim to analyse the factors responsible for the formation of a carbon granuloma (CG) following transoral laser microlaryngeal cordectomy (TLMC) for early glottic carcinoma. Our study comprises of retrospective data analysis of 78 patients who underwent TLMC for early glottic carcinoma between 2012 and 2017 with the laser settings of an acublade with scanning system, size 1-2 mm, depth 1-3 (250-750 μm), power 10 watts in a repeat mode with time off 0.25 s. Read More

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http://dx.doi.org/10.1007/s10103-019-02726-3DOI Listing
February 2019
1 Read
2.489 Impact Factor

Outcomes of carotid-sparing IMRT for T1 glottic cancer: Comparison with conventional radiation.

Laryngoscope 2019 Feb 12. Epub 2019 Feb 12.

Multidisciplinary Larynx Cancer Working Group from the Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, U.S.A.

Objectives: We aim to report oncologic outcomes after conventional radiotherapy (ConRT) using opposed lateral beams and intensity-modulated radiation therapy (IMRT) for tumor (T)1 nodal (N)0 T1 N0 glottic squamous cell carcinoma.

Study Design: Retrospective case-control study.

Methods: We retrospectively reviewed demographic, disease, and treatment characteristics for patients treated at our institution during 2000 to 2013. Read More

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http://dx.doi.org/10.1002/lary.27873DOI Listing
February 2019
4 Reads

Dysphagia optimized radiotherapy to reduce swallowing dysfunction severity in patients undergoing treatment for head and neck cancer: A systematized scoping review.

Head Neck 2019 Feb 5. Epub 2019 Feb 5.

Division of Speech Pathology, School of Health and Rehabilitation Sciences, The University of Queensland, St Lucia, Queensland, Australia.

This study involved a systematized scoping review to coalesce current evidence on dysphagia outcomes achieved through active sparing of the swallowing structures in patients receiving radiotherapy for head and neck cancer. Eligible publications between 2007 and 2017 were reviewed and synthesized regarding participant demographics, treatment regimens, swallowing structures chosen for optimization, dosimetric constraints, and dysphagia measures. Nine prospective cohort studies were included. Read More

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http://dx.doi.org/10.1002/hed.25688DOI Listing
February 2019
1 Read

Randomized controlled single-blinded clinical trial of functional voice outcome after vascular targeting KTP laser microsurgery of early laryngeal cancer.

Head Neck 2019 Apr 31;41(4):899-907. Epub 2019 Jan 31.

Department of Otorhinolaryngology-Section of Phoniatrics, Ludwig-Maximilians-University Medical Center, Munich, Germany.

Background: Local control rate (LCR) of early glottic cancer is high after radiation therapy or transoral laser microsurgery (TLM). The aim of this study was to investigate functional voice outcome after TLM using a microvessel-ablative potassium-titanyl-phosphate (KTP) laser in comparison with a gold standard cutting CO laser.

Methods: The primary end point of this prospective, randomized, single-blinded, clinical phase II study with control group was voice outcome during a follow-up of 6 months assayed by Voice Handicap Index (VHI-30)-questionnaires in patients with unilateral high-grade dysplasia, carcinoma in situ or early glottic cancer undergoing TLM-KTP (n = 8) or TLM-CO (n = 12). Read More

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http://dx.doi.org/10.1002/hed.25474DOI Listing

Ultrasonography guided fine needle aspiration cytology in patients with laryngo-hypopharyngeal lesions.

Braz J Otorhinolaryngol 2018 Dec 28. Epub 2018 Dec 28.

All India Institute Of Medical sciences, Department of Otorhinolaryngology, New Delhi, India.

Introduction: Laryngeal lesions are usually evaluated by microlaryngoscopy/direct laryngoscopy under anaesthesia for disease mapping and tissue diagnosis. However patients with anticipated airway compromise due to laryngeal mass may require either a protective tracheotomy or emergency tracheotomy to secure the airway. To minimise risk of unplanned tracheotomy and expedite the diagnosis we performed ultrasound-guided transcutaneous fine needle aspiration cytology. Read More

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http://dx.doi.org/10.1016/j.bjorl.2018.11.005DOI Listing
December 2018
2 Reads

Lower cranial nerve palsy during radiotherapy for glottic cancer in a patient with Wegener's granulomatosis: An interesting case report.

Mol Clin Oncol 2019 Jan 19;10(1):147-152. Epub 2018 Oct 19.

Department of Radiation Oncology, S. Giuseppe Moscati Hospital, I-74100 Taranto, Italy.

The aim of the present study was to report an unusual case of multiple lower cranial nerve palsies in a patient with Wegener's granulomatosis (WG) during radiotherapy for glottic cancer. WG is an autoimmune disease characterized by necrotizing granulomas mainly in the upper and lower respiratory tract or kidneys; however, the involvement of cranial nerves is not uncommon. Prior to the use of cyclophosphamide (CYC) the 1-year mortality rate was ~82%; the introduction of rituximab (RTX) has revolutionized the course of the WG, with remission rates comparable to those of CYC and superior effectiveness in relapsing patients. Read More

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http://dx.doi.org/10.3892/mco.2018.1748DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6315903PMC
January 2019
9 Reads

Voice outcome after unilateral ELS type III or bilateral type II resections for T1-T2 glottic carcinoma: Results after 1 year.

Head Neck 2019 Jan 16. Epub 2019 Jan 16.

Department of Otorhinolaryngology, Head & Neck Surgery, Leiden University Medical Center, Leiden, The Netherlands.

Background: Voice outcome was assessed in patients with extended T1 and limited T2 glottic carcinoma, treated with a unilateral type III or a bilateral type II resection according to the European Laryngological Society (ELS) classification.

Methods: Objective evaluation (acoustic and aerodynamic parameters), perceptual evaluation (GRBAS), and patients' self-assessment (voice handicap index [VHI]) were performed before and 1 year after treatment. Results were evaluated according to ELS resection type and the involvement of the anterior commissure. Read More

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http://dx.doi.org/10.1002/hed.25582DOI Listing
January 2019
3 Reads

Transoral laser microsurgery for glottic cancer in the elderly: Efficacy and safety.

Head Neck 2019 Jan 12. Epub 2019 Jan 12.

International Head and Neck Scientific Group, Padua, Italy.

Background: Data about the results of transoral laser microsurgery (TLM) in elderly patients are limited.

Methods: A retrospective study of 72 consecutive cases of glottic carcinoma (63 pT1 and 9 pT2 cases) in elderly patients (≥70 years old, mean 76 years) treated with TLM was made. A systematic review of the literature was performed. Read More

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http://dx.doi.org/10.1002/hed.25616DOI Listing
January 2019
7 Reads

Prediction of Posterior Paraglottic Space and Cricoarytenoid Unit Involvement in Endoscopically T3 Glottic Cancer with Arytenoid Fixation by Magnetic Resonance with Surface Coils.

Cancers (Basel) 2019 Jan 10;11(1). Epub 2019 Jan 10.

Department of Otorhinolaryngology, Maxillofacial, and Thyroid Surgery, Fondazione IRCCS, Istituto Nazionale dei Tumori di Milano, University of Milan, 20133 Milan, Italy.

Discrimination of the etiology of arytenoid fixation in cT3 laryngeal squamous cell carcinoma (SCC) is crucial for treatment planning. The aim of this retrospective study was to differentiate among possible causes of arytenoid fixation (edema, inflammation, mass effect, or tumor invasion) by analyzing related signal patterns of magnetic resonance (MR) in the posterior laryngeal compartment (PLC) and crico-arytenoid unit (CAU). Seventeen patients affected by cT3 glottic SCC with arytenoid fixation were preoperatively studied by state-of-the-art MR with surface coils. Read More

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http://dx.doi.org/10.3390/cancers11010067DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6356606PMC
January 2019
2 Reads

A new approach to vocal cord leukoplakia and evaluation of proton pump ınhibitor treatment.

Eur Arch Otorhinolaryngol 2019 Feb 3;276(2):467-471. Epub 2019 Jan 3.

Department of Otorhinolaryngology, Faculty of Medicine, Bezmialem Vakif University, Fatih, Istanbul, Turkey.

Purpose: Our aim is identify a new approach to vocal cord leukoplakia treatment and detect to efficiency of proton pump inhibitors.

Study Design: Prospective, nonrandomized experimental clinical trial.

Methods: A 'First Assessment Scale' was prepared. Read More

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http://dx.doi.org/10.1007/s00405-018-05273-9DOI Listing
February 2019
2 Reads

Transoral laser microsurgery in early glottic cancer involving the anterior commissure.

Eur Arch Otorhinolaryngol 2019 Mar 2;276(3):837-845. Epub 2019 Jan 2.

Department of Otorhinolaryngology, Head and Neck Surgery, Ludwig-Maximilians-University Munich, Marchioninistr. 15, 81377, Munich, Germany.

Purpose: Treatment modalities for glottic cancer comprise surgery, (chemo-)radiation, and combined treatment options. Glottic cancer involving the anterior commissure (AC) requires special preoperative assessment and surgical skills, as it is commonly considered a risk factor for local recurrence. The aim of this study is to analyze the oncological effectiveness of transoral laser microsurgery (TLM) in the early glottic cancer involving the AC. Read More

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http://dx.doi.org/10.1007/s00405-018-5261-4DOI Listing

Carcinoma Presenting as Idiopathic Anterior Glottic Webs: A Case Series.

Laryngoscope 2018 Dec 28. Epub 2018 Dec 28.

Columbia University Medical Center Department of Otolaryngology, New York, New York.

An anterior glottic web is an abnormal fusion of the anterior aspect of the membranous vocal folds. Noncongenital glottic webs are usually iatrogenic from intubation or laryngeal surgery. We present six adult patients whose initial in-office diagnoses were consistent with "idiopathic" benign anterior glottic webs as determined by three laryngologists (a. Read More

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http://doi.wiley.com/10.1002/lary.27711
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http://dx.doi.org/10.1002/lary.27711DOI Listing
December 2018
2 Reads

Double pyramid technique of transoral laser partial laryngectomy for radiorecurrent laryngeal cancer.

BMJ Case Rep 2018 Nov 28;11(1). Epub 2018 Nov 28.

Department of Otorhinolaryngology, Ninewells Hospital, NHS Tayside, Dundee, UK.

Management of recurrent head and neck cancer is challenging. Surgical treatments for residual or radiorecurrent laryngeal cancer include total laryngectomy, open partial laryngectomy and transoral laser microsurgery (TLM). TLM has been shown to achieve good oncological and functional outcomes in radiorecurrent laryngeal cancer. Read More

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http://dx.doi.org/10.1136/bcr-2018-224915DOI Listing
November 2018
2 Reads

Prognostic impact of initial treatment in surgically salvaged recurrences of early glottic cancer.

Laryngoscope 2018 Dec 18. Epub 2018 Dec 18.

Department of Otorhinolaryngology, Careggi University Hospital, Florence, Italy.

Objective: The purpose of this study was to analyze the outcomes of surgically salvaged early glottic cancer (EGC) recurrences after initial radiotherapy (RT) or transoral laser microsurgery (TLM).

Methods: A matched pair analysis by recurrent tumor-node-metastasis stage (rTNM) considering 27 patients who had TLM as initial treatment and 54 patients who failed after primary RT was performed. Post-recurrence overall and disease-specific survival (DSS) were evaluated. Read More

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http://dx.doi.org/10.1002/lary.27702DOI Listing
December 2018
4 Reads

Molecular and immunologic analysis of laryngeal squamous cell carcinoma in smokers and non-smokers.

Am J Otolaryngol 2019 Mar - Apr;40(2):213-217. Epub 2018 Nov 22.

Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins Hospital, Baltimore, MD, USA.

Background: Laryngeal squamous cell carcinoma (LSCC) is strongly associated with tobacco use, but recent reports suggest an increasing incidence of LSCC in patients without traditional risk factors, suggesting an alternative etiology of tumorigenesis. The purpose of this study is to characterize this non-smoking population and to compare immunohistochemical markers in tumor specimens from non-smokers and smokers with LSCC.

Methods: A retrospective chart review of patients with LSCC at Johns Hopkins Hospital (JHH) was performed. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01960709183088
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http://dx.doi.org/10.1016/j.amjoto.2018.11.009DOI Listing
November 2018
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Long-term changes in vocal function after supracricoid partial laryngectomy with cricohyoidoepiglottopexy for laryngeal cancer.

Head Neck 2019 Jan 12;41(1):139-145. Epub 2018 Dec 12.

Department of Otolaryngology-Head and Neck Surgery, Graduate School of Medicine, Kumamoto University, Kumamoto, Japan.

Background: The purpose of this study was to assess changes in vocal function over time following supracricoid partial laryngectomy with cricohyoidoepiglottopexy (SCL-CHEP).

Methods: A total of 17 patients who underwent SCL-CHEP for laryngeal squamous cell carcinoma between 2007 and 2015 were reviewed. We examined maximum phonation time (MPT), mean airflow rate (MFR), voice intensity, the grade, roughness, breathiness, asthenia, and strain (GRBAS) scale, Voice Handicap Index-10 (VHI-10), and voice-related quality of life (V-RQOL) scores. Read More

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http://dx.doi.org/10.1002/hed.25487DOI Listing
January 2019

Phonosurgical Resection Using Submucosal Infusion Technique for Early Glottic Lesions: Diagnostic and Therapeutic Procedure?

Ann Otol Rhinol Laryngol 2019 Apr 14;128(4):277-285. Epub 2018 Dec 14.

1 Clinic of Otolaryngology, Head and Neck Surgery, Department of Translational Surgery and Medicine, Careggi University Hospital, Florence, Italy.

Objectives:: The aim of this study was to assess the feasibility of the submucosal infusion combined with microflap dissection via laser CO2 as both a diagnostic and therapeutic procedure for superficial glottic lesions. To define a safe surgical procedure in terms of local control, a morphometric study of surgical margins was performed.

Methods:: From January 2011 to January 2016, we treated 122 patients with early glottic lesions with phonomicrosurgery. Read More

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http://dx.doi.org/10.1177/0003489418819544DOI Listing
April 2019
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Efficacy of laser surgery versus radiotherapy for treatment of glottic carcinoma: a systematic review and meta-analysis.

Lasers Med Sci 2018 Dec 6. Epub 2018 Dec 6.

Nursing College of Shanxi Medical University, Taiyuan, 030001, Shanxi, People's Republic of China.

Laser surgery and radiotherapy are the two most common ways to treat glottic carcinomas, which is more efficacious and remains controversial. PubMed, Embase, and Cochrane Library were searched to identify relevant studies of laser surgery versus radiotherapy in patients with glottic carcinomas through April 2017. Sensitivity analysis and subgroup analysis were performed to evaluate heterogeneity. Read More

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http://dx.doi.org/10.1007/s10103-018-2695-2DOI Listing
December 2018
3 Reads

Completion Total Laryngectomy Ten Years After Near Total Laryngectomy for Radiorecurrent Cancer of the Glottis.

Indian J Surg Oncol 2018 Dec 9;9(4):605-608. Epub 2018 Aug 9.

Division of Surgical Oncology (Head and Neck Services), Regional Cancer Centre, Trivandrum, Kerala 695011 India.

Near total laryngectomy (NTL) is a safe alternative to total laryngectomy in salvaging lateralized radiation failures. A 65-year-old gentleman with radiorecurrent T1 vocal cord cancer was salvaged successfully by NTL. Ten years later, he presented with a strained shunt speech which was treated judiciously, with the aid of a positron emission tomography (PET) scan, by a (completion) total laryngectomy (TL), bilateral selective neck dissection, and pharyngeal resurfacing with pectoralis major myocutaneous (PMMC) flap. Read More

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http://dx.doi.org/10.1007/s13193-018-0795-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6265171PMC
December 2018
4 Reads

Symmetrical Apophyses on the Posterior Margins of the Thyroid Cartilage: A Previously Undescribed Anatomical Variation With Potential Forensic Implications.

Am J Forensic Med Pathol 2019 Mar;40(1):84-88

Departamento de Anatomía y Embriología Humana Facultad de Medicina, Universidad Complutense de Madrid, Madrid, Spain.

Differential diagnosis between normal/variant anatomy and pathological/traumatic findings represents one of the main matters of investigation of the so-called forensic clinical anatomy. In the literature, many anatomical variations of the laryngeal thyroid cartilage have been reported, with potential implications in forensic pathology. They include triticeal cartilages, foramen thyroideum, asymmetry, segmentation or agenesis of the superior thyroid horns, bone connections with the hyoid bone, absence of cricothyroid facets, hypertrophy of the inferior thyroid tubercle, and asymmetries in the thyroid notch, isthmus, or length of the inferior horn. Read More

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http://Insights.ovid.com/crossref?an=00000433-900000000-9917
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http://dx.doi.org/10.1097/PAF.0000000000000452DOI Listing
March 2019
4 Reads

Treatment of early-stage laryngeal cancer: A comparison of treatment options.

Oral Oncol 2018 Dec 16;87:8-16. Epub 2018 Oct 16.

Stanford University School of Medicine, Department of Otolaryngology Head and Neck Surgery, USA.

Over the course of the last several decades, the treatment options for early laryngeal cancers (T1 and T2) have evolved; however, simultaneously the mortality rate has increased. As larynx preservation approaches have become the standard of care, the selection of the proper treatment modality has become paramount. Radiation therapy or transoral laser microsurgery are the most common options for treatment of these early lesions. Read More

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http://dx.doi.org/10.1016/j.oraloncology.2018.09.012DOI Listing
December 2018
2 Reads

Outcomes of Treating Early Glottic Neoplasms With a Potassium Titanyl Phosphate Laser.

Ann Otol Rhinol Laryngol 2019 Feb 11;128(2):85-95. Epub 2018 Dec 11.

2 Auckland City Hospital, Auckland, New Zealand.

Objectives:: The aim of this study was to assess the outcome of treating glottic dysplasia and early squamous cell carcinoma (SCC) with potassium titanyl phosphate (KTP) photoangiolytic laser ablation.

Methods:: Patient demographics, comorbidities, and tumor characteristics were recorded. Perceptual, patient-reported, and objective voice outcomes were assessed. Read More

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http://dx.doi.org/10.1177/0003489418806914DOI Listing
February 2019
10 Reads

Carbon Dioxide Laser Microsurgery versus Low-Temperature Plasma Radiofrequency Ablation for T1a Glottic Cancer: A Single-Blind Randomized Clinical Trial.

Biomed Res Int 2018 1;2018:4295960. Epub 2018 Nov 1.

Department of Otolaryngology, The Third Hospital of Wuhan City, Wuhan, Hubei Province, China.

Background: Very few studies have been conducted to compare carbon dioxide laser microsurgery (CO2-LS) with low-temperature plasma radiofrequency ablation (LTP-RFA) in treating T1a glottic cancer. Therefore, we conducted this study to compare the efficacy of CO2-LS and LTP-RFA to define a superior therapeutic modality for T1a glottic cancer.

Methods: Patients (n=131) with T1a glottic cancer were recruited between January 2010 and September 2014. Read More

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http://dx.doi.org/10.1155/2018/4295960DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6241367PMC
March 2019
3 Reads

Impact of the anterior commissure involvement on the survival of early glottic cancer treated with cricohyoidoepiglottopexy: a retrospective study.

Cancer Manag Res 2018 8;10:5553-5558. Epub 2018 Nov 8.

Otolaryngology, Department of Health Sciences, University of Catanzaro, Catanzaro, Italy,

Background: Laryngeal early glottic tumors can benefit from different treatment modalities, including transoral laser microsurgery, open partial horizontal laryngectomy (OPHL), and radiotherapy. However, the treatment of early glottic tumors with the involvement of the anterior commissure remains controversial. The studies about the role of anterior commissure involvement in oncologic outcomes in patients with early glottic cancer treated with supracricoid laryngectomy (SCL) are very few. Read More

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http://dx.doi.org/10.2147/CMAR.S182854DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6234988PMC
November 2018
3 Reads

Omitting the lower neck and sparing the glottic larynx in node-negative nasopharyngeal carcinoma was safe and feasible, and improved patient-reported voice outcomes.

Clin Transl Oncol 2018 Dec 4. Epub 2018 Dec 4.

Department of Oral and Maxillofacial-Head Neck Oncology, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, 639 Zhizaoju Road, Shanghai, 200011, People's Republic of China.

Background: Worsening voice and speech quality was frequently reported in head-and-neck patients after radiotherapy to the neck; omitting the lower neck and sparing the glottic larynx in node-negative nasopharyngeal carcinoma (NPC) patients might be safe and feasible, and improve voice and speech outcomes.

Methods: From January 2009 to January 2013, 71 patients were analyzed. All patients received bilateral neck irradiation. Read More

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http://dx.doi.org/10.1007/s12094-018-1988-zDOI Listing
December 2018
12 Reads

Long Term Oncological Results of Transoral Laser Microsurgery for Early and Moderately Advanced Glottic Carcinoma in Primary and Salvage Settings.

Indian J Otolaryngol Head Neck Surg 2018 Dec 29;70(4):463-470. Epub 2018 Sep 29.

1Department of Otolaryngology and Head & Neck Surgery, All India Institute of Medical Sciences, New Delhi, 110029 India.

The aim of the study is to document the long term oncological results of trans-oral laser microsurgery (TLM) for early and moderately advanced glottic cancer in primary and salvage settings. In this prospective cohort study 43 consecutive patients of glottic cancer (T1-30, T2-7, and selected T3 with mobile cords-6) were recruited. TLM was performed in these 35 primary and 8 previously treated cases. Read More

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http://dx.doi.org/10.1007/s12070-018-1505-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6224817PMC
December 2018
20 Reads

[Impact of Respiratory Motion on Dose Variation in Radiation Therapy for Glottic Cancer].

Nihon Hoshasen Gijutsu Gakkai Zasshi 2018;74(11):1269-1274

Department of Radiation Therapy, Cancer Institute Hospital.

In radiation therapy for glottic cancer, respiratory motion of larynx may change the dose variation in the target. The purpose of this study is to measure the respiratory motion of the larynx, and quantify the impact of the motion on the dose variation. This study included 10 patients treated by opposing portal irradiation for glottic cancer. Read More

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http://dx.doi.org/10.6009/jjrt.2018_JSRT_74.11.1269DOI Listing
March 2019
10 Reads