1,833 results match your criteria Glomerulonephritis Rapidly Progressive


Abnormal Chest Radiograph in Rapidly Progressive Glomerulonephritis - Not the Usual Pulmonary-Renal Syndrome.

Am J Med 2019 Apr 15. Epub 2019 Apr 15.

Department of Renal Medicine, Singapore General Hospital. Electronic address:

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http://dx.doi.org/10.1016/j.amjmed.2019.03.038DOI Listing
April 2019
1 Read

Cardiac Point-of-Care Ultrasound for the Diagnosis of Infective Endocarditis in a Patient with Non-Specific Rheumatologic Symptoms and Glomerulonephritis.

Am J Case Rep 2019 Apr 18;20:542-547. Epub 2019 Apr 18.

Weill Department of Medicine, Weill Cornell Medicine, New York City, NY, USA.

BACKGROUND Point-of-care ultrasound (POCUS) is performed at the bedside by a healthcare professional who is directly caring for the patient. Subacute infective endocarditis can be challenging to diagnose, as patients often present with non-specific symptoms. The modified Duke criteria include echocardiographic findings as a major criterion, but the role of POCUS has not been established. Read More

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https://www.amjcaserep.com/abstract/index/idArt/914708
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http://dx.doi.org/10.12659/AJCR.914708DOI Listing
April 2019
3 Reads

Local miscommunications between glomerular cells as potential therapeutic targets for crescentic glomerulonephritides.

Nephrol Ther 2019 Apr;15 Suppl 1:S1-S5

Inserm, Paris Cardiovascular Centre (Parcc), 56, rue Leblanc, 75015 Paris, France; Université Paris Descartes, Sorbonne Paris Cité, 12, rue de l'École-de-Médecine, 75006 Paris, France. Electronic address:

Necrotizing and crescentic rapidly progressive glomerulonephritis or crescentic glomerulonephritis is one of the severest forms of acquired glomerular diseases with significant mortality. Risk of end-stage renal failure at 5 years is near 30%, with a number of patients developing chronic kidney disease. Currently, autoimmune crescentic glomerulonephritides are treated with broad-spectrum immunosuppression inducing remission of the injury in the majority of patients. Read More

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http://dx.doi.org/10.1016/j.nephro.2019.03.006DOI Listing
April 2019
1 Read

Chest High-Resolution CT Findings of Microscopic Polyangiitis: A Japanese First Nationwide Prospective Cohort Study.

AJR Am J Roentgenol 2019 Apr 11:1-11. Epub 2019 Apr 11.

1 Department of Respiratory Medicine, Toho University Omori Medical Center, Ota-ku Omori nisi 6-11-1, Tokyo 143-8541, Japan.

Objective: The lung is one of the organs possibly involved in microscopic polyangiitis (MPA), and myeloperoxidase (MPO) antineutrophil cytoplasmic antibody (ANCA) is commonly found in patients with MPA. The aim of this study was to assess pulmonary lesions in Japanese patients with MPA.

Subjects And Methods: This prospective study was based on 144 patients with MPA who were enrolled in the Remission Induction Therapy in Japanese Patients With ANCA-Associated Vasculitis and Rapidly Progressive Glomerulonephritis Study and who underwent chest high-resolution CT (HRCT) imaging at the time of diagnosis during 2011-2014. Read More

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http://dx.doi.org/10.2214/AJR.18.20967DOI Listing
April 2019
3 Reads

Microscopic polyangiitis associated with thymic tumor: a case report and review of the literature.

BMC Nephrol 2019 Apr 8;20(1):123. Epub 2019 Apr 8.

Department of Nephrology, Tokyo Medical University Ibaraki Medical Center, 3-20-1 Chuo, Ami, Ibaraki, 300-0395, Japan.

Background: Thymic hyperplasia and thymic epithelial tumor (thymoma) have been associated with a variety of autoimmune diseases. Renal involvement has been reported in patients with thymoma. Minimal change disease and membranous nephropathy are frequently observed in glomerular lesions of thymoma patients, but ANCA-associated renal vasculitis is rare. Read More

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http://dx.doi.org/10.1186/s12882-019-1319-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454690PMC
April 2019
1 Read

Rapidly Progressive Glomerulonephritis Secondary to IgA Nephropathy in a Patient with Systemic Lupus Erythematosus.

Case Rep Nephrol 2019 5;2019:8354823. Epub 2019 Mar 5.

Department of Internal Medicine, Division of Nephrology, Houston, TX, USA.

Lupus nephritis is a common manifestation of systemic lupus erythematosus (SLE). IgA nephropathy is a common type of primary glomerulonephritis. Renal manifestations in SLE patients are often due to lupus nephritis; however, renal diseases unrelated to lupus nephritis are rarely reported. Read More

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https://www.hindawi.com/journals/crin/2019/8354823/
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http://dx.doi.org/10.1155/2019/8354823DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425374PMC
March 2019
4 Reads

A relapsing case of pulmonary-renal syndrome after a sequential rise in MPO-ANCA and anti-GBM antibodies.

CEN Case Rep 2019 Apr 3. Epub 2019 Apr 3.

Department of Nephrology and Rheumatology, Gunma University Graduate School of Medicine, 3-39-22 Showa, Maebashi, Gunma, 371-8511, Japan.

A 69-year-old woman who presented with severe renal dysfunction and diffuse alveolar hemorrhage was diagnosed with pulmonary-renal syndrome (PRS) based on the coexistence of serum myeloperoxidase (MPO)-antineutrophil cytoplasmic antibodies (ANCA) and anti-glomerular basement membrane (GBM) antibodies (Ab). Hemodialysis was started; plasma exchange and intravenous methylprednisolone pulse therapy were administered followed by oral prednisolone administration. Pulmonary hemorrhage decreased; however, renal dysfunction persisted. Read More

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http://dx.doi.org/10.1007/s13730-019-00397-1DOI Listing
April 2019
1 Read

A Liquid-Based Cytology System, without the Use of Cytocentrifugation, for Detection of Podocytes in Urine Samples of Patients with Diabetic Nephropathy.

J Diabetes Res 2019 17;2019:9475637. Epub 2019 Feb 17.

Division of Nephrology, Endocrinology and Metabolism, Department of Internal Medicine, Tokai University School of Medicine, Isehara, Japan.

Objective: Podocytes have highly differentiated functions and are extremely difficult to grow; thus, damage of podocytes is associated with glomerular dysfunction. Desquamated podocytes can be detected in urine of patients with severe renal impairment. Unlike the rapidly progressive glomerular damage in glomerulonephritis, only a few desquamated podocytes are usually detected in diabetic nephropathy (DN). Read More

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http://dx.doi.org/10.1155/2019/9475637DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6398024PMC
February 2019
1 Read

Anca negative pauci-immune crescentic glomerulonephritis and mixed connective tissue disease: a case study.

J Bras Nefrol 2019 Mar 18. Epub 2019 Mar 18.

Hospital Beatriz Angelo, Loures, Portugal.

One of the most common causes of rapidly progressive glomerulonephritis (RPGN) is pauci-immune crescentic glomerulonephritis (CrGN). In the majority of cases, this condition has a positive serologic marker, the anti-neutrophil cytoplasmic antibodies (ANCAs), but in approximately 10% there are no circulating ANCAs, and this subgroup has been known as the ANCA-negative pauci-immune CrGN. RPGN can be associated with systemic diseases, but there are only few case reports describing the association with mixed connective tissue disease (MCTD). Read More

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http://dx.doi.org/10.1590/2175-8239-JBN-2019-0003DOI Listing
March 2019
1 Read

Spectrum of acute kidney injury associated with cocaine use: report of three cases.

BMC Nephrol 2019 Mar 20;20(1):99. Epub 2019 Mar 20.

Medical Sciences Postgraduate Program, Department of Internal Medicine, School of Medicine, Estadual University of Ceará, Fortaleza, Brazil.

Background: The consequences of cocaine use are multisystemic, such as, for instance, renal failure, hepatotoxicity and pulmonary toxicity, with renal alterations being the focus of the present study. The use of substances that modify the base composition of cocaine (or adulterants) aiming to potentiate its effects also has an impact on these manifestations. The present study aims to report three cases with different diagnosis of acute kidney injury related to cocaine use. Read More

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http://dx.doi.org/10.1186/s12882-019-1279-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6427899PMC
March 2019
3 Reads

Role of CD8+ T cells in crescentic glomerulonephritis.

Nephrol Dial Transplant 2019 Mar 16. Epub 2019 Mar 16.

Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Crescentic glomerulonephritis (cGN) comprises three main types according to the pathogenesis and immunofluorescence patterns: anti-glomerular basement membrane antibody cGN, vasculitis-associated cGN and post-infectious immune complex cGN. In this brief review of the immune-pathogenesis of cGN, the focus is mainly on the role of CD8+ T cells in the progression of cGN. Under control conditions, Bowman's capsule (BC) provides a protected immunological niche by preventing access of cytotoxic CD8+ T cells to Bowman's space and thereby podocytes. Read More

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http://dx.doi.org/10.1093/ndt/gfz043DOI Listing
March 2019
2 Reads

Granulomatosis with polyangiitis in a patient with biopsy-proven IgG4-related pulmonary disease and coincident small cell lung cancer.

BMJ Case Rep 2019 Mar 14;12(3). Epub 2019 Mar 14.

Rheumatology (111R), Minneapolis VA HCS, Minneapolis, Minnesota, USA.

Granulomatosis with polyangiitis (GPA) was diagnosed in a patient with a 16-month history of IgG4-related lung disease that spontaneously became asymptomatic. Cytoplasmic antineutrophil cytoplasmic antibody (ANCA) was positive at the time of diagnosis of IgG4-related disease (IgG4-RD), but there was no vasculitis or kidney disease. Sixteen months later he developed rapidly progressive glomerulonephritis that responded to cyclophosphamide treatment. Read More

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http://dx.doi.org/10.1136/bcr-2018-226280DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6424371PMC
March 2019
3 Reads

[Rapid progressive glomerulonephritis].

Authors:
Marion Haubitz

Internist (Berl) 2019 Mar 13. Epub 2019 Mar 13.

Medizinische Klinik III - Nieren- und Hochdruckerkrankungen, Klinikum Fulda gAG, Universitätsmedizin Marburg - Campus Fulda, Pacelliallee 4, 36043, Fulda, Deutschland.

The rapid progressive glomerulonephritis is an emergency case. Renal function is rapidly lost within weeks or a few months (rarely within days) due to necrotizing extracapillary proliferative crescentic glomerulonephritis. Early diagnosis and treatment improve prognosis, as the best prognostic marker is creatinine when treatment is initiated. Read More

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http://link.springer.com/10.1007/s00108-019-0575-x
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http://dx.doi.org/10.1007/s00108-019-0575-xDOI Listing
March 2019
5 Reads

[Membranoproliferative glomerulonephritis and C3 glomerulopathy].

Internist (Berl) 2019 Mar 11. Epub 2019 Mar 11.

Klinik für Nieren- und Hochdruckerkrankungen, Medizinische Hochschule Hannover, Hannover, Deutschland.

Based on an increasingly better pathophysiological understanding over the last 10 years, in 2010 a new classification of glomerulonephritis with dominant or codominant C3 deposits was introduced and the predominant subgoup was termed C3 glomerulopathy (C3G). In the current classification, immune complex mediated membranoproliferative glomerulonephritis (IC-MPGN) and C3 glomerulopathy (C3G) form a disease spectrum which is very heterogeneous in terms of pathophysiology and the clinical course. Recent evidence suggests that IC-MPGN and C3G share more pathophysiological aspects with respect to secondary causes, autoantibodies and genetic aspects than had been suggested with the creation of the new classification. Read More

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http://dx.doi.org/10.1007/s00108-019-0572-0DOI Listing
March 2019
1 Read

[Lupus nephritis].

Internist (Berl) 2019 Mar 6. Epub 2019 Mar 6.

Medizinische Klinik III (Nephrologie, Hypertensiologie, Rheumatologie), Sana Klinikum Offenbach GmbH, KfH-Nierenzentrum Offenbach, Starkenburgring 66-70, 63069, Offenbach, Deutschland.

Lupus nephritis (LN) is the most frequent and one of the most severe organ manifestations of systemic lupus erythematosus. The central pathogenetic mechanism is characterized by the loss of immune tolerance against autoantigens of the cell nucleus, which can lead to renal inflammation via the formation of nuclear autoantibodies. The clinical manifestations of LN encompass nephritic syndrome with the special form of rapidly progressive glomerulonephritis, nephrotic syndrome and thrombotic microangiopathy. Read More

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http://dx.doi.org/10.1007/s00108-019-0574-yDOI Listing
March 2019
1 Read

Spectrum of biopsy proven renal disease in northern India: a single centre study.

Nephrology (Carlton) 2019 Mar 4. Epub 2019 Mar 4.

Department of Nephrology, All India Institute of Medical Sciences, New Delhi, India-110029.

Aim: Pattern of kidney diseases varies across geographies due to multiple factors. There is a paucity of information from South Asia due to absence of nationwide/regional biopsy registries. This study aimed to delineate the spectrum of renal parenchymal diseases in our region. Read More

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http://doi.wiley.com/10.1111/nep.13582
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http://dx.doi.org/10.1111/nep.13582DOI Listing
March 2019
14 Reads

Pharmacological inhibition of protease-activated receptor-2 reduces crescent formation in rat nephrotoxic serum nephritis.

Clin Exp Pharmacol Physiol 2019 May 25;46(5):456-464. Epub 2019 Mar 25.

Department of Nephrology, Monash Medical Centre, Clayton, Victoria, Australia.

Glomerular crescent formation is a hallmark of rapidly progressive forms of glomerulonephritis. Thrombosis and macrophage infiltration are features of crescent formation in human and experimental kidney disease. Protease-activated receptor-2 (PAR-2) is a G-protein coupled receptor that links coagulation and inflammation. Read More

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http://dx.doi.org/10.1111/1440-1681.13077DOI Listing
May 2019
3 Reads

Successful use of rituximab for hydralazine-induced anti-neutrophil cytoplasmic antibodies-associated vasculitis.

Saudi J Kidney Dis Transpl 2019 Jan-Feb;30(1):226-230

Department of Medicine, Division of Nephrology, Washington University School of Medicine, St. Louis, MO, USA.

Hydralazine is a commonly used anti-hypertensive medication. It can, however, contribute to the development of autoimmunity, in the form of drug-induced lupus and anti-neutrophil cytoplasmic antibodies-associated vasculitis. We report a 45-year-old patient with hypertension managed with hydralazine for four years who presented with rapidly progressive glomerulonephritis (RPGN), requiring hemodialysis, and diffuse alveolar hemorrhage (DAH), requiring mechanical ventilation, and extracorporeal membrane oxygenation. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6435256PMC
February 2019

[Acute renal failure of glomerular origin].

Authors:
Éric Thervet

Rev Prat 2018 Feb;68(2):160-165

Service de néphrologie, département hypertension artérielle, prévention et prise en charge des affections rénales et cardiovasculaires, Hôpital européen Georges-Pompidou, Assistance publique-Hôpitaux de Paris, université Paris-Descartes Paris, France.

Acute renal failure of glomerular origin. Glomerulopathies account for about 10% of acute kidney injury (AKI) in adults. They often require urgent care. Read More

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February 2018
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Neurologic manifestations associated with cryoglobulinemia: A single center experience.

J Neurol Sci 2019 Mar 25;398:121-127. Epub 2019 Jan 25.

Department of Neurology, Cleveland Clinic Foundation, Cleveland, OH 44195, United States. Electronic address:

Introduction: Limited information is available describing the spectrum of neurological complications of cryoglobulinemia.

Methods: Single center retrospective review of patients with neurologic symptoms and elevated serum cryoglobulins, with their potential association being classified as definite, possible, or unlikely using defined criteria.

Results: Among 492 patients, 131 (87 classified as definite and 44 as possible) had neurologic symptoms associated with cryoglobulinemia. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0022510X193005
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http://dx.doi.org/10.1016/j.jns.2019.01.041DOI Listing
March 2019
11 Reads

A case of aggressive atypical anti-GBM disease complicated by CMV pneumonitis.

BMC Nephrol 2019 Jan 31;20(1):29. Epub 2019 Jan 31.

Department of Pathology and Laboratory Medicine, Cumming School of Medicine, University of Calgary, Foothills Medical Center, 1403 29 St NW, Calgary, AB, T2N 2T9, Canada.

Background: Anti-glomerular basement membrane (anti-GBM) disease is characterized by circulating IgG glomerular basement membrane antibodies and is clinically expressed as a rapidly progressive crescentic glomerulonephritis (GN), with 30-60% of patients also developing pulmonary hemorrhage. Classically, the renal biopsy shows glomerular crescent formation, bright linear staining of glomerular basement membranes (GBM) for IgG on direct immunofluorescence (IF), and the serologic presence of circulating anti-GBM antibodies. Recently, patients with linear IgG IF staining, undetectable circulating anti-GBM antibodies and glomerular changes atypical for anti-GBM disease have been described as "atypical anti-GBM disease", with a distinctly more benign clinical course than typical anti-GBM disease. Read More

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http://dx.doi.org/10.1186/s12882-019-1227-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357502PMC
January 2019
5 Reads

Atypical Goodpasture's disease: a clinical case report and literature review.

Ter Arkh 2018 Jun;90(6):130-136

I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenov University), Moscow, Russia.

Goodpasture's disease (anti-GBM disease) is a rare small vessels vasculitis characterized by the presence of autoantibodies directed against the glomerular basement membrane (GBM) and alveolar basement membrane. Common feature of anti-GBM disease is a combination of rapidly progressive glomerulonephritis and alveolar hemorrhage (pulmonary-renal syndrome). We present a case of atypical disease course in a young male patient who developed alveolar hemorrhage without renal failure. Read More

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http://dx.doi.org/10.26442/terarkh2018906130-136DOI Listing
June 2018
2 Reads

Clinical features of kidney involvement in microscopic microscopic polyangiitis.

Ter Arkh 2018 Jun;90(6):55-58

I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenov University), Moscow, Russia.

Aim: To evaluate clinical features and outcomes of renal involvement in patients with microscopic polyangiitis (MPA).

Materials And Methods: We enrolled 99 patients with MPA, diagnosed in accordance with the algorithm of the European Medicines Evaluation Agency (EMEA) and the Chapel Hill consensus conference definition (2012). Serum creatinine (sCr), estimated glomerular filtration rate (eGFR), hematuria and proteinuria were estimated. Read More

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http://dx.doi.org/10.26442/terarkh201890655-58DOI Listing
June 2018
3 Reads

Relationship between serologic profile (ANCA type) and clinical features of renal involvement in ANCA-associated vasculitides.

Ter Arkh 2018 Jun;90(6):15-21

I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenov University), Moscow, Russia.

Aim: To compare the frequency, clinical features and outcomes of renal involvement in ANCA-associated vasculitides (AAV) in patients with antibodies against proteinase-3 (pr3-ANCA) and myeloperoxidase (MPO-ANCA).

Materials And Methods: In our retrospective study we enrolled 264 patients, 94 males and 170 females, median age 53 [36; 62] years. Among them 157 were pr3-ANCA positive and 107 were MPO-ANCA positive. Read More

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http://dx.doi.org/10.26442/terarkh201890615-21DOI Listing
June 2018
2 Reads

Diagnostic algorithm for antineutrophil cytoplasmic antibody-associated systemic vasculitis.

Authors:
T V Beketova

Ter Arkh 2018 May;90(5):13-22

V.A. Nasonova Scientific Research Institute of Rheumatology, Moscow, Russia.

Antineutrophil cytoplasm antibody (ANCA)-associated vasculitis (AAV) are rare autoimmune disorders and characterized by severe multiple organ lesions with a potential fatal outcome. AAV comprises granulomatosis with polyangiitis (GPA), microscopic polyangiitis (MPA) and eosinophilic granulomatosis with polyangiitis (EGPA). Early diagnosis and treatment can significantly improve the AAV prognosis, but there are can be difficult, largely due to the lack of criteria for the classification MPA, whose main difference is the absence of granulomatous inflammation. Read More

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http://dx.doi.org/10.26442/terarkh201890513-22DOI Listing
May 2018
2 Reads

Development of anti-glomerular basement membrane glomerulonephritis during the course of IgA nephropathy: a case report.

BMC Nephrol 2019 Jan 25;20(1):25. Epub 2019 Jan 25.

Department of Nephrology and Blood Purification, Kidney Disease Center, Tokyo Medical University Hachioji Medical Center, 1163 Tatemachi, Hachioji, Tokyo, 193-0998, Japan.

Background: Anti-glomerular basement membrane (GBM) glomerulonephritis does not usually coexist with another glomerulonephritis such as IgA nephropathy. We present a rare case having a combination of these two diseases, and furthermore, histological evaluation could be performed before and after the development of anti-GBM glomerulonephritis over a period of only10 months.

Case Presentation: A 66-year-old woman was admitted with complaints of microscopic hematuria and mild proteinuria for the past 3 years. Read More

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http://dx.doi.org/10.1186/s12882-019-1207-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347754PMC
January 2019
8 Reads

Leukocytoclastic vasculitis with late-onset Henoch-Schönlein purpura after trifluridine/tipiracil treatment.

Dermatol Online J 2018 Oct 15;24(10). Epub 2018 Oct 15.

Department of Dermatology, The University of Texas McGovern Medical School, Houston, Texas.

Trifluridine/tipiracil has been approved for the treatment of refractory metastatic colorectal cancer. Adverse effects of this drug combination include leukopenia, neutropenia, fatigue, diarrhea, and vomiting. We present a case of trifluridine/tipiracil-induced leukocytoclastic vasculitis (LCV) with late-onset Henoch-Schönlein purpura (HSP) in a 42-year-old man with metastatic appendiceal cancer. Read More

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October 2018
4 Reads

Acute renal failure in a patient with PR3-ANCA and monoclonal immunoglobulin deposition disease: Case report.

Medicine (Baltimore) 2018 Dec;97(52):e13799

Institute of Health Policy, Management, and Evaluation, University of Toronto, Canada.

Rationale: Acute renal failure developing over a short period of time with evidence of glomerular disease by urine sediment microscopy characterizes the clinical syndrome of rapidly progressive glomerulonephritis (RPGN), of which the most common causes are ANCA-associated glomerulonephritis (GN), immune-complex mediated GN and anti-GBM disease.

Patient Concerns: This was a middle-aged gentleman who presented with acute renal failure and a positive PR3-ANCA.

Diagnosis: Renal biopsy showed an unusual combination of PR3-ANCA GN with focal crescents, monoclonal immunoglobulin deposition disease (MIDD) and mesangial IgA deposition on renal biopsy. Read More

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http://Insights.ovid.com/crossref?an=00005792-201812280-0004
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http://dx.doi.org/10.1097/MD.0000000000013799DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6314724PMC
December 2018
5 Reads

Cerebral venous sinus thrombosis as a warning signal for double positive crescentic glomerulonephritis in a young male with complete renal recovery.

Saudi J Kidney Dis Transpl 2018 Nov-Dec;29(6):1488-1493

Department of Renal Pathology, Lal Path Lab, New Delhi, India.

Double positive crescentic glomerulonephritis is relatively rare in young population and has variable outcomes. Although increased incidence of deep venous thrombosis in antineutrophil cytoplasmic antibody-associated vasculitis has been reported, cerebral venous sinus thrombosis (CVT) is very rare. We present a young male who presented with CVT followed by rapidly progressive crescentic glomerulonephritis and with appropriate therapeutic modalities he had complete renal and partial neurological recovery. Read More

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http://dx.doi.org/10.4103/1319-2442.248291DOI Listing
December 2018
154 Reads

ANCA-Associated Necrotizing Glomerulonephritis Overlapping with Mesangial Proliferative Lupus Nephritis Refractory to Plasmapheresis, Steroid Pulse Therapy, and a Combination of Mycophenolate Mofetil and Rituximab.

Case Rep Rheumatol 2018 19;2018:3076806. Epub 2018 Nov 19.

Division of Rheumatology, SUNY Upstate Medical University, Syracuse, NY 13210, USA.

Necrotizing glomerulonephritis (GN) associated with antineutrophil cytoplasmic antibody (ANCA) has been increasingly recognized in the context of class III or IV lupus nephritis (LN), hereafter designated as . While this subset of GN appears to portend an unfavorable renal outcome, it is not clear whether it represents a distinct entity and benefits from a more aggressive therapy. We report a 78-year-old woman who presented with rapidly progressive GN and was found to have a double-stranded DNA (dsDNA) antibody, hypocomplementemia, antiphospholipid antibody, and strongly positive myeloperoxidase antibody. Read More

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http://dx.doi.org/10.1155/2018/3076806DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276453PMC
November 2018
3 Reads

Rare heparin induced thrombocytopenia type I reaction in a hemodialysis patient: Case report.

Medicine (Baltimore) 2018 Dec;97(50):e13609

Department of Pharmacy.

Rationale: Heparin-induced thrombocytopenia (HIT) is a common antibody-mediated adverse reaction that occurs after heparin exposure. However, few case reports exist regarding nonantibody-mediated HIT.

Patient Concerns And Diagnoses: An 81-year-old female diagnosed with rapidly progressive glomerulonephritis (RPGN) presented with atypical presentation of non antibody-meditated HIT after using heparin during hemodialysis. Read More

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http://dx.doi.org/10.1097/MD.0000000000013609DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320049PMC
December 2018
2 Reads
5.723 Impact Factor

Correlation between Pathological Findings and the Usefulness of Clinical Guidelines for the Treatment of ANCA-Positive RPGN: A Retrospective Analysis.

J Nippon Med Sch 2018 ;85(5):259-264

Department of Nephrology, Nippon Medical School.

Background: The physical condition of patients with anti-neutrophil cytoplasmic antibody (ANCA)-associated rapidly progressive glomerulonephritis (RPGN) is at times too critical for physicians to undertake a renal biopsy. In such cases, physicians need to start treatments without determining the pathological features of the disease. However, the prevalent clinical practice guidelines for ANCA-associated RPGN in Japan do not necessitate the pathological findings in a renal biopsy for determining first-line treatments. Read More

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http://dx.doi.org/10.1272/jnms.JNMS.2018_85-41DOI Listing
February 2019
16 Reads

Infection-Related Glomerulonephritis.

Pediatr Clin North Am 2019 02;66(1):59-72

Division of Nephrology, Boston Children's Hospital, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA.

Acute postinfectious glomerulonephritis or infection-related glomerulonephritis has been associated with several viral or bacterial infections. Group A beta-hemolytic streptococcal infection is the prototypical cause of postinfectious glomerulonephritis and the main focus of this discussion. The clinical spectrum can vary widely, from asymptomatic microscopic hematuria incidentally detected on routine urinalysis to rapidly progressive glomerulonephritis with acute kidney injury requiring emergent dialysis. Read More

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http://dx.doi.org/10.1016/j.pcl.2018.08.005DOI Listing
February 2019
22 Reads

Successful pregnancy in a patient with pulmonary renal syndrome double-positive for anti-GBM antibodies and p-ANCA
.

Clin Nephrol 2019 Feb;91(2):101-106

Background: Antiglomerular basement membrane (anti-GBM) antibody disease is a rare condition causing pulmonary hemorrhage and necrotizing glomerulonephritis (pulmonary renal syndrome).

Case: We report a 30-year-old woman who presented with life-threatening pulmonary hemorrhage and an active urinary sediment, with normal glomerular filtration rate in the 13 week of pregnancy. Anti-GBM antibodies in serum were negative, but perinuclear antineutrophil cytoplasmatic antibodies (p-ANCA) were detected. Read More

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http://dx.doi.org/10.5414/CN109584DOI Listing
February 2019
7 Reads

Hydralazine-associated antineutrophil cytoplasmic antibody vasculitis with pulmonary-renal syndrome.

BMJ Case Rep 2018 Nov 8;2018. Epub 2018 Nov 8.

Nephrology, Deaconess Health System, Evansville, Indiana, USA.

Hydralazine, a vasodilator, is commonly used as an adjunctive treatment for moderate to severe hypertension, heart failure and hypertensive emergencies in pregnancy. Hydralazine-induced lupus was first described in 1953. Clinical presentation ranges from arthralgia, myalgia, petechiae, or rash to single or multiorgan involvement. Read More

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http://casereports.bmj.com/lookup/doi/10.1136/bcr-2018-22716
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http://dx.doi.org/10.1136/bcr-2018-227161DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6229221PMC
November 2018
12 Reads

A case report of granulomatous polyangiitis complicated by tuberculous lymphadenitis.

Medicine (Baltimore) 2018 Oct;97(43):e12430

Lung Cancer and Respiratory Disease Center, Yamanashi Central Hospital.

Rational: Granulomatous polyangiitis (GPA) is a type of vasculitis involving medium and small arteries, typically affecting the upper and lower respiratory tract with coexisting glomerulonephritis. GPA is also characterized by necrotizing granulomatous inflammation and the presence of antineutrophil cytoplasm antibodies (ANCA). So far, various infections have lead to elevation of titers of serum ANCA, making it difficult to diagnose. Read More

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http://Insights.ovid.com/crossref?an=00005792-201810260-0000
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http://dx.doi.org/10.1097/MD.0000000000012430DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6221664PMC
October 2018
18 Reads

Antiglomerular Basement Membrane Disease.

Semin Respir Crit Care Med 2018 08 7;39(4):494-503. Epub 2018 Nov 7.

Department of Medicine, Centre for Inflammatory Disease, Imperial College London, London, United Kingdom.

Antiglomerular basement membrane (anti-GBM) disease is a rare but life-threatening autoimmune vasculitis that is characterized by the development of pathogenic autoantibodies to type IV collagen antigens expressed in the glomerular and alveolar basement membranes. Once deposited in tissue, these autoantibodies incite a local capillaritis which manifests as rapidly progressive glomerulonephritis (GN) in 80 to 90% of patients, and with concurrent alveolar hemorrhage in ∼50%. A small proportion of cases may present with pulmonary disease in isolation. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/s-0038-1669413
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http://dx.doi.org/10.1055/s-0038-1669413DOI Listing
August 2018
14 Reads

Microscopic Polyangiitis: New Insights into Pathogenesis, Clinical Features and Therapy.

Authors:
Alexandre Karras

Semin Respir Crit Care Med 2018 08 7;39(4):459-464. Epub 2018 Nov 7.

Department of Nephrology, Hôpital Européen Georges Pompidou, Assistance Publique- Hôpitaux de Paris, Paris France.

Microscopic polyangiitis (MPA) is one of the main clinical presentations of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitides. Although the disease is defined by clinical and pathological criteria, the anti-myeloperoxidase (MPO) specificity of ANCAs is observed in almost 80% of MPA patients. The direct pathogenic role of anti-MPO antibodies has been proven in animal models, in which the disease was transmitted by transfer of anti-MPO antibodies or anti-MPO-specific splenocytes. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/s-0038-1673387
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http://dx.doi.org/10.1055/s-0038-1673387DOI Listing
August 2018
13 Reads

Temporal change in life and renal prognosis of rapidly progressive glomerulonephritis in Japan via nationwide questionnaire survey.

Clin Exp Nephrol 2019 Apr 31;23(4):573-575. Epub 2018 Oct 31.

Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.

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http://dx.doi.org/10.1007/s10157-018-1663-2DOI Listing
April 2019
3 Reads

Immune complex-mediated rapidly progressive glomerulonephritis in a patient with family history of systemic lupus erythematosus.

Saudi J Kidney Dis Transpl 2018 Sep-Oct;29(5):1227-1231

Department of Pathology, King Abdulaziz Medical City, Riyadh, Saudi Arabia.

We describe here a case of a 53-year-old Saudi female who presented to the emergency room with shortness of breath progressive in nature for the previous one month, associated with a cough and occasional greenish sputum. She turned out to be a case of immunocomplex mediated glomerulonephritis presenting as rapidly progressive glomerulonephritis in a female patient with a history of systemic lupus erythematosus (SLE) in her daughter. Read More

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http://dx.doi.org/10.4103/1319-2442.243949DOI Listing
November 2018
3 Reads

Analysis of native kidney biopsy: Data from a single center from Bihar, India.

Saudi J Kidney Dis Transpl 2018 Sep-Oct;29(5):1174-1180

Department of Nephrology, Indira Gandhi Institute of Medical Sciences, Patna, Bihar, India.

This is a retrospective study of all native kidney biopsies performed at our center between October 1, 2012 and March 31, 2015. Relevant clinical and laboratory variables were recorded. Biopsy samples were processed for light microscopy and immunofluorescence in all cases. Read More

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http://www.sjkdt.org/text.asp?2018/29/5/1174/243975
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http://dx.doi.org/10.4103/1319-2442.243975DOI Listing
November 2018
5 Reads

Anti-glomerular basement membrane disease: an update on subgroups, pathogenesis and therapies.

Nephrol Dial Transplant 2018 Oct 29. Epub 2018 Oct 29.

Lund University, Skane University Hospital, Department of Clinical Sciences Lund, Nephrology, Lund, Sweden.

Most patients with anti-glomerular basement membrane (anti-GBM) disease present with rapidly progressive glomerulonephritis with or without pulmonary haemorrhage; however, there are several variants and vigilance is necessary to make a correct diagnosis. Such variants include overlap with anti-neutrophil cytoplasm antibodies-associated vasculitis and membranous nephropathy as well as anti-GBM occurring de novo after renal transplantation. Moreover, patients can present with isolated pulmonary haemorrhage as well as with negative tests for circulating anti-GBM. Read More

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http://dx.doi.org/10.1093/ndt/gfy327DOI Listing
October 2018
16 Reads

Bacterial endocarditis manifesting as autoimmune pulmonary renal syndrome: ANCA-associated lung hemorrhage and pauci-immune crescentic glomerulonephritis
.

Clin Nephrol 2018 Dec;90(6):431-433

The etiology of pulmonary renal syndrome can be broadly divided into infectious and autoimmune (predominantly ANCA vasculitis). The importance of timely differentiating between them stems from the deleterious effects of their respective treatment if misdiagnosed. Serology and tissue evaluation by pathology are employed to aid in this, however, in rare cases, this can be difficult. Read More

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http://dx.doi.org/10.5414/CN109495DOI Listing
December 2018
20 Reads

Membranous nephropathy followed by anti-glomerular basement disease: A case report and review of clinical presentation and treatment.

SAGE Open Med Case Rep 2018 19;6:2050313X18807621. Epub 2018 Oct 19.

Department of Nephrology, Heidelberg University Hospital, Heidelberg, Germany.

Membranous nephropathy is a common cause of nephrotic syndrome in adults and can be primary or secondary through autoimmune disease, medication, infection, or malignancy. Rapidly progressive glomerulonephritis with crescent formation is rare in patients with membranous nephropathy. Thus, in cases with rapid decline in renal function, after excluding complications such as malignant hypertension, acute hypersensitivity interstitial nephritis, and bilateral renal vein thrombosis, the simultaneous occurrence of a superimposed glomerulonephritis should be considered. Read More

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http://journals.sagepub.com/doi/10.1177/2050313X18807621
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http://dx.doi.org/10.1177/2050313X18807621DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6196619PMC
October 2018
13 Reads

A unique case of rapidly progressive glomerulonephritis following dexamethasone/bortezomib/thalidomide treatment for myeloma.

Nephrology (Carlton) 2018 11;23(11):1065-1067

Department of Medicine, Nephrology, University of Padova, Padova, Italy.

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http://dx.doi.org/10.1111/nep.13249DOI Listing
November 2018
5 Reads

Histopathological Classification-A Prognostic Tool for Rapidly Progressive Glomerulonephritis.

Medicina (Kaunas) 2018 Apr 17;54(2). Epub 2018 Apr 17.

Centre of Nephrology, Vilnius University Hospital Santaros Klinikos, LT⁻08661 Vilnius, Lithuania.

Recently proposed histopathological classification may predict patient outcome in pauci-immune glomerulonephritis. This study sought to prove that the prognostic effect could be extended to all types of rapidly progressive glomerulonephritis. Retrospective analysis of patients diagnosed with rapidly progressive glomerulonephritis between April 1999 and August 2015 was performed. Read More

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http://www.mdpi.com/1648-9144/54/2/17
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http://dx.doi.org/10.3390/medicina54020017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6037248PMC
April 2018
11 Reads

Histopathological classification of anti-neutrophil cytoplasmic antibody-associated glomerulonephritis in a nationwide Japanese prospective 2-year follow-up cohort study.

Clin Exp Nephrol 2019 Mar 10;23(3):387-394. Epub 2018 Oct 10.

Department of Nephrology, Internal Medicine, Nagoya University Graduate School of Medicine, Aichi, Japan.

Background: The prognostic value of the EUVAS-proposed histopathological classification of anti-neutrophil cytoplasmic antibody (ANCA)-associated glomerulonephritis has been evaluated throughout the world. Here, we performed a Japanese nationwide biopsy survey to assess the association between this histopathological classification and renal prognosis after 2-year follow-up in ANCA-associated glomerulonephritis.

Methods: We collected 67 renal biopsy materials of the 321 entries in the RemIT-JAV-RPGN cohort study, and assessed their histologies. Read More

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http://dx.doi.org/10.1007/s10157-018-1656-1DOI Listing
March 2019
5 Reads

Successful treatment of steroid-refractory double-positive ANCA and anti-GBM disease with a combination of plasma exchange and immunosuppression: A case report and literature review.

Respir Med Case Rep 2018 1;25:242-246. Epub 2018 Oct 1.

Division of Neurology, Respirology, Endocrinology and Metabolism, Department of Internal Medicine, Faculty of Medicine, University of Miyazaki, Kiyotake, Miyazaki, 889-1692, Japan.

The concurrence of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) and anti-glomerular basement membrane (GBM) disease, known as double-positive disease, is rare, but it occurs at a much higher frequency than expected by chance. Double-positive disease has an aggressive clinical course, with no optimal treatment strategy. Here we describe a patient with steroid-refractory double-positive disease who was treated successfully with the addition of plasma exchange (PE) and cyclophosphamide (CPA). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22130071183027
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http://dx.doi.org/10.1016/j.rmcr.2018.09.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6174835PMC
October 2018
15 Reads

Anti-Glomerular Basement Membrane Disease.

Rheum Dis Clin North Am 2018 11 7;44(4):651-673. Epub 2018 Sep 7.

Renal and Vascular Inflammation Section, Department of Medicine, Imperial College London, Commonwealth Building, Hammersmith Hospital Campus, Du Cane Road, London W12 ONN, UK; Vasculitis Clinic, Imperial College Healthcare NHS Trust, Hammersmith Hospital, Du Cane Road, London W12 0HS, UK. Electronic address:

Anti-glomerular basement membrane (anti-GBM) disease is a rare autoimmune small vessel vasculitis characterized by autoreactivity to antigens in type IV collagen chains expressed in glomerular and alveolar basement membrane. The detection of circulating anti-GBM antibodies, which are shown to be directly pathogenic, is central to disease diagnosis. Clinically, anti-GBM disease usually presents with rapidly progressive glomerulonephritis with or without alveolar hemorrhage. Read More

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http://dx.doi.org/10.1016/j.rdc.2018.06.011DOI Listing
November 2018
6 Reads

Renal Involvement in Antineutrophil Cytoplasmic Antibody-Associated Vasculitis.

Rheum Dis Clin North Am 2018 11 7;44(4):525-543. Epub 2018 Sep 7.

Division of Nephrology, Vasculitis and Glomerulonephritis Center, Massachusetts General Hospital, 101 Merrimac Street, Boston, MA 02114, USA. Electronic address:

Antineutrophil cytoplasmic antibody-associated vasculitis (AAV) is the most common cause of rapidly progressive glomerulonephritis. ANCAs play an important role in the pathogenesis and diagnosis of AAV. The classic renal lesion in AAV is a pauci-immune necrotizing and crescentic glomerulonephritis. Read More

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http://dx.doi.org/10.1016/j.rdc.2018.06.001DOI Listing
November 2018
15 Reads