1,911 results match your criteria Glomerulonephritis Rapidly Progressive


Cholesterol Emboli Co-Existing with Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis in a 76-Year-Old Woman.

Tohoku J Exp Med 2020 05;251(1):61-68

Department of Nephrology, Shinshu University Hospital.

Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis injures small vessels and causes severe systemic organ injury. Main target antigens of ANCA are myeloperoxidase and proteinase 3. ANCA strongly associates with the development and progression of the vasculitis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1620/tjem.251.61DOI Listing

Glomerular Diseases Associated with Malignancies: Histopathological Pattern and Association with Circulating Autoantibodies.

Antibodies (Basel) 2020 May 25;9(2). Epub 2020 May 25.

Nephrology Department & Transplantation Unit, Faculty of Medicine, Laiko Hospital, National & Kapodistrian University of Athens, 11527 Athens, Greece.

Aim: Glomerular diseases (GD) associated with malignancies (AM, GDAM) have unique features, which are important to recognize, in the light of the progress made in cancer therapy. We aimed to describe the clinical and histopathological characteristics of patients with GDAM in relation to the presence of circulating autoantibodies, pointing to potential immune pathogenic pathways connecting cancer to GD.

Materials And Methods: The included patients were studied retrospectively on the basis of a kidney biopsy proving GD and a related biopsy to establish the diagnosis of AM. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/antib9020018DOI Listing

A case of ANCA associated vasculitis in a patient presenting with chest pain.

J Int Med Res 2020 May;48(5):300060520925940

Emergency Department, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong Province, China.

Antineutrophil cytoplasmic antibody (ANCA) associated vasculitis (AAV) is a group of multisystem autoimmune small vessel diseases. We report here a case of a 68-year-old woman who initially presented with 29-day history of chest pain, malaise and anorexia. Cardiac problems were ruled out and she was considered to have pneumonia. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/0300060520925940DOI Listing

Narrative Review of Hypercoagulability in Small-Vessel Vasculitis.

Kidney Int Rep 2020 May 13;5(5):586-599. Epub 2020 Jan 13.

Department of Internal Medicine, Section on Nephrology, Wake Forest School of Medicine, Winston Salem, North Carolina, USA.

Pauci-immune necrotizing and crescentic glomerulonephritis (GN) is the most common etiology of rapidly progressive GN. Clinical presentation in those afflicted is usually related to rapid loss of kidney function. We report the case of a 70-year-old woman who came to medical attention for signs and symptoms related to lower-extremity deep vein thrombosis (DVT). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ekir.2019.12.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7210611PMC

Atypical Anti-Glomerular Basement Membrane Disease With Diffuse Crescentic Membranoproliferative Glomerulonephritis: Case Report and Review of Literature.

Qatar Med J 2020 5;2020(1):16. Epub 2020 May 5.

Division of Nephrology, Department of Medicine, Hamad Medical Corporation, Doha, Qatar.

Anti-glomerular basement membrane (anti-GBM) disease occurs in fewer than two cases per million population. Patients usually present with features of rapidly progressive glomerulonephritis (RPGN) with or without pulmonary involvement. Anti-GBM disease is classically diagnosed by both demonstrating GBM linear immunofluorescence staining on kidney biopsy and detecting anti-GBM antibodies in serum. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5339/qmj.2020.16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7199789PMC

A case report of progressive multifocal leukoencephalopathy during steroid treatment for ANCA-associated renal vasculitis.

CEN Case Rep 2020 May 9. Epub 2020 May 9.

Division of Clinical Medicine, Department of Nephrology, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennoudai, Tsukuba, Ibaraki, 305-8575, Japan.

Case Report: an 80-year-old woman presented with rapidly progressive glomerulonephritis and was admitted to our hospital. Myeloperoxidase-specific antineutrophil cytoplasmic antibody (MPO-ANCA) was positive. We diagnosed ANCA-associated renal vasculitis (ANCA-RV). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s13730-020-00482-wDOI Listing

Rapidly progressive glomerulonephritis caused by tegafur/gimeracil/oteracil resulted in diabetes nephropathy, in a patient with minor risk of diabetes nephropathy: a case report.

CEN Case Rep 2020 May 7. Epub 2020 May 7.

Nephrology Center and Department of Rheumatology, Toranomon Hospital Kajigaya, 1-3-1, Takatsu, Kawasaki, Kanagawa, 212-0015, Japan.

A 79-year-old Japanese male with a history of type 2 diabetes mellitus (T2DM) for 16 years was admitted to evaluate possible renal disease. The T2DM was well controlled in this patient using nutrition therapy without the need for any diabetes medication, and both diabetes retinopathy and proteinuria were negative. At the age of 78 advanced colorectal cancer (stage IIIa) was diagnosed and laparoscopic-assisted colectomy was performed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s13730-020-00485-7DOI Listing

Update on C3 Glomerulopathy: A Complement-Mediated Disease.

Nephron 2020 May 5:1-9. Epub 2020 May 5.

Instituto de Investigación Hospital 12 de octubre (i+12), Madrid, Spain.

C3 glomerulopathy (C3G) is a clinicopathologic entity secondary to dysregulation of the alternative complement pathway in plasma and the glomerular microenvironment. The current consensus definition of C3G relies on immunofluorescence staining criteria. However, due to its high clinical variability, these criteria may not be accurate enough in some clinical scenarios. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000507254DOI Listing

IgA vasculitis and anti-GBM disease: two ends of a spectrum of immune complex vasculitis.

Authors:
Alan D Salama

Rheumatology (Oxford) 2020 May;59(Supplement_3):iii118-iii122

UCL Department of Renal Medicine, Royal Free Hospital, London, UK.

Two immune complex vasculitides, IgA vasculitis (IgAV) and anti-GBM disease, represent polar extremes with regard to our understanding of disease pathogenesis, standardized management protocols and outcomes. This report compares our current approach to these uncommon entities in adults. Both diseases demonstrate degrees of small vessel necrosis and glomerular crescent formation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/rheumatology/kez540DOI Listing

Prognostic Value of Neutrophil-To-Lymphocyte Ratio and Platelet-To-Lymphocyte Ratio for Renal Outcomes in Patients with Rapidly Progressive Glomerulonephritis.

J Clin Med 2020 Apr 15;9(4). Epub 2020 Apr 15.

Division of Medicine and Clinical Science, Faculty of Medicine, Tottori University, Yonago, Tottori 683-8504, Japan.

Background: Rapidly progressive glomerulonephritis (RPGN) is a syndrome characterized by a rapid decline in renal function that often causes end-stage renal disease. Although it is important to predict renal outcome in RPGN before initiating immunosuppressive therapies, no simple prognostic indicator has been reported. The aim of this study was to investigate the associations of neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) to renal outcomes in patients with RPGN. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/jcm9041128DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7230792PMC

Hansen's disease with lepra reaction presenting with IgA dominant infection related glomerulonephritis.

Indian J Pathol Microbiol 2020 Apr-Jun;63(2):289-291

Department of Nephrology, Institute of Nephrology, Madras Medical College and Rajiv Gandhi Government General Hospital, Chennai, Tamil Nadu, India.

Various renal abnormalities in leprosy have been described largely in literature but the occurrence of IgA dominant infection related glomerulonephritis in leprosy with type 2 lepra reaction has not been reported so far. We present here a 60-year-old man with a history of leprosy in the past admitted with type 2 lepra reaction, rapidly progressive glomerulonephritis with severe renal failure requiring dialysis and diagnosed to have IgA dominant infection related glomerulonephritis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4103/IJPM.IJPM_654_17DOI Listing
April 2020
0.642 Impact Factor

Anti-glomerular basement membrane disease: A clinicomorphological study of 16 cases.

Indian J Pathol Microbiol 2020 Apr-Jun;63(2):226-229

Department of Nephrology, Nizam's Institute of Medical Sciences, Punjagutta, Hyderabad, Telangana, India.

Introduction: Antiglomerular basement membrane disease manifests as rapidly progressive glomerulonephritis and alveolar hemorrhage. It encompasses 10-15% of crescentic glomerulonephritis and is associated with poor outcome. In this study, we have elaborated on the clinical details, morphological features, and outcome of anti-GBM glomerulonephritis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4103/IJPM.IJPM_712_18DOI Listing

Rapidly progressive glomerulonephritis due to systemic lupus erythematosus and ANCA-associated vasculitis overlap.

Lupus 2020 Apr 21:961203320920368. Epub 2020 Apr 21.

Rheumatology Division, Internal Medicine Department, School of Medicine, The University of Jordan, Amman Jordan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/0961203320920368DOI Listing

Anti-glomerular basement membrane disease complicated with posterior reversible encephalopathy syndrome and subcortical cerebral hemorrhage: a case report and review of the literature.

CEN Case Rep 2020 Apr 10. Epub 2020 Apr 10.

Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-Ku, Fukuoka, 8128582, Japan.

A 71-year-old woman was hospitalized for the treatment of fatigue, fever, and cough. On admission, she showed increased serum inflammation markers, severe anemia, pulmonary hemorrhage, and advanced acute kidney injury requiring hemodialysis. Her serum anti-glomerular basement membrane (GBM) antibody titer was found to be extremely high on the 7th hospital day. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s13730-020-00473-xDOI Listing

Use of Rituximab in Management of Rapidly Progressive Glomerulonephritis.

Cureus 2020 Jan 30;12(1):e6820. Epub 2020 Jan 30.

Internal Medicine, California Institute of Behavioral Neurosciences and Psychology, Fairfield, USA.

Rapidly progressive glomerulonephritis (RPGN) is a form of glomerulonephritis characterized by loss of renal function within weeks. Although a variety of underlying causes can trigger RPGN, the ultimate pathologic mechanism is the podocyte and epithelial activation leading to the crescent formation. Rituximab has been increasingly and successfully used for autoimmune conditions in recent years. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.7759/cureus.6820DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7051118PMC
January 2020

Symmetric polyneuropathy after viral symptomatology - not always Guillain-Barré Syndrome.

Acta Clin Belg 2020 Mar 13:1-8. Epub 2020 Mar 13.

Department of Nephrology, AZ St. Elisabeth Hospital, Zottegem, Belgium.

: Guillain-Barré Syndrome usually presents with ascending symmetric polyneuropathy, typically preceded by a viral infection. Despite the low incidence, physicians will often include Guillain-Barré Syndrome in their differential diagnosis. However, another underlying cause of polyneuropathy known as ANCA-associated vasculitis (AAV) is even more rare than Guillain-Barré Syndrome and therefore is usually overlooked. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/17843286.2020.1740858DOI Listing

Clinical Profile and Outcome of IgA Nephropathy from a Tertiary Care Hospital in North India.

J Assoc Physicians India 2020 Mar;68(3):20-22

Professor and Head, Departments of Nephrology, Indira Gandhi Medical College, Shimla, Himachal Pradesh; Corresponding Author.

Aim: To study the clinical profile and outcome of the patients with kidney biopsy diagnosis of IgA Nephropathy (IgAN).

Methods: A retrospective study of the patients diagnosed IgAN over a period of three and half years.

Results: Sixty (13. Read More

View Article

Download full-text PDF

Source

The glomerular crescent: triggers, evolution, resolution, and implications for therapy.

Curr Opin Nephrol Hypertens 2020 May;29(3):302-309

Renal Division, Department of Medicine IV, University Hospital of the Ludwig Maximilian University, Munich, Germany.

Purpose Of Review: Crescents are classical histopathological lesions found in severe forms of rapidly progressive glomerulonephritis, also referred to as crescentic glomerulonephritis (CGN). Crescent formation is a consequence of diverse upstream pathomechanisms and unraveling these mechanisms is of great interest for improving the management of patients affected by CGN. Thus, in this review, we provide an update on the latest insight into the understanding on how crescents develop and how they resolve. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/MNH.0000000000000596DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7170443PMC

Renal Transplantation in Antineutrophil Cytoplasmic Antibody-Associated Vasculitis: Current Perspectives.

Kidney Blood Press Res 2020 19;45(2):157-165. Epub 2020 Feb 19.

Division of Nephrology, Department of Medicine, Johns Hopkins Bayview Medical Center, Johns Hopkins University, Baltimore, Maryland, USA,

Background: Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is the leading cause of rapidly progressive glomerulonephritis, which may follow an unfavorable disease course. Despite therapeutic advances, a number of patients with AAV will eventually develop end-stage renal disease (ESRD). Renal transplantation (RTx) is associated with a survival benefit and improves quality of life in patients with ESRD. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000505660DOI Listing
February 2020

[C3 glomerulopathy and MPGN - current classification].

Authors:
Bernd Hohenstein

Dtsch Med Wochenschr 2020 Feb 18;145(4):232-239. Epub 2020 Feb 18.

Membranoproliferative glomerulonephritis (MPGN) and glomerulopathy with dominant C3 deposits are very rare autoimmune disorders of the kidney that had been classified in its current form in 2010 due to a better understanding of the underlying pathophysiology.Today, the immune complex-associated membranoproliferative glomerulonephritis (IC-MPGN) and C3 glomerulopathy (C3G) represent a disease spectrum which is heterogeneous in terms of pathophysiology and the clinical time course. Interestingly, recent research demonstrated more common pathophysiological aspects with respect to secondary causes, autoantibodies, and genetics of IC-MPGN and C3G than it had been suggested with the creation of the 2010 classification. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1055/a-0974-8418DOI Listing
February 2020

A Functional Landscape of CKD Entities From Public Transcriptomic Data.

Kidney Int Rep 2020 Feb 13;5(2):211-224. Epub 2019 Nov 13.

Faculty of Medicine, RWTH Aachen University, Joint Research Centre for Computational Biomedicine (JRC-COMBINE), Aachen, Germany.

Introduction: To develop effective therapies and identify novel early biomarkers for chronic kidney disease, an understanding of the molecular mechanisms orchestrating it is essential. We here set out to understand how differences in chronic kidney disease (CKD) origin are reflected in gene expression. To this end, we integrated publicly available human glomerular microarray gene expression data for 9 kidney disease entities that account for most of CKD worldwide. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ekir.2019.11.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7000845PMC
February 2020

Rapidly progressive glomerulonephritis (RPGN) in Hansen's disease.

J Assoc Physicians India 2020 Jan;68(1):75

SS Institute of Medical Science & RC.

View Article

Download full-text PDF

Source
January 2020

Interventions for renal vasculitis in adults.

Cochrane Database Syst Rev 2020 01 13;1:CD003232. Epub 2020 Jan 13.

The Children's Hospital at Westmead, Cochrane Kidney and Transplant, Centre for Kidney Research, Locked Bag 4001, Westmead, NSW, Australia, 2145.

Background: Renal vasculitis presents as rapidly progressive glomerulonephritis and comprises of a group of conditions characterised by acute kidney injury (AKI), haematuria and proteinuria. Treatment of these conditions involve the use of steroid and non-steroid agents in combination with plasma exchange. Although immunosuppression overall has been very successful in treatment of these conditions, many questions remain unanswered in terms of dose and duration of therapy, the use of plasma exchange and the role of new therapies. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/14651858.CD003232.pub4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6956643PMC
January 2020

A Case of Diffuse Alveolar Hemorrhage Associated with High-Titer of MPO-ANCA Demonstrating Cytoplasmic Staining Pattern.

Case Rep Rheumatol 2019 12;2019:6074792. Epub 2019 Dec 12.

Division of Rheumatology, SUNY Upstate Medical University, 750 East Adams Street, Syracuse, NY 13210, USA.

Diffuse alveolar hemorrhage (DAH) is a life-threatening complication of ANCA-associated vasculitis (AAV) that requires urgent recognition and treatment. A presumptive diagnosis is often rendered without histopathology if concordant positivity of ANCA by indirect immunofluorescence (IIF) and ELISA assays, i.e. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1155/2019/6074792DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6930762PMC
December 2019

Lupus Nephritis Class IV-Global Is Associated with a Higher Risk of End-Stage Renal Disease than Class IV-Segmental.

Nephron 2020 7;144(3):118-125. Epub 2020 Jan 7.

Department of Nephrology, Clinical Hospital, Federal University of Pernambuco, Recife, Brazil.

Introduction: The International Society of Nephrology/Renal Pathology Society (ISN/RPS) classification of lupus nephritis (LN) divides class IV into segmental and global (IV-S and IV-G) based on evidence suggesting different renal outcomes. However, subsequent studies have shown conflicting results.

Objective: This study was performed to compare long-term renal outcomes between the IV-S and IV-G classes. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000505404DOI Listing
January 2020

Membranous Glomerulonephritis With Crescents.

Kidney Int Rep 2019 Nov 13;4(11):1577-1584. Epub 2019 Aug 13.

Centre for Inflammatory Disease, Division of Immunology and Inflammation, Department of Medicine, Imperial College London, London, UK.

Introduction: Membranous glomerulonephritis (MGN) is rarely associated with necrotizing and crescentic glomerulonephritis (NCGN).

Methods: We report the clinical and pathologic findings in 15 patients with MGN and NCGN associated with anti-neutrophil cytoplasm antibodies (ANCAs), anti-glomerular basement membrane (GBM), or anti-phospholipase A2 receptor (PLA2R) antibodies.

Results: The cohort consisted of 15 patients: 7 males and 8 females with a median age of 63 years (range: 18-79). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ekir.2019.07.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6933443PMC
November 2019

Comparison of the performance of a chemiluminescence assay and an ELISA for detection of anti-GBM antibodies.

Ren Fail 2020 Nov;42(1):48-53

Renal Division, Department of Medicine, Peking University First Hospital, Beijing, PR. China.

Autoantibodies to the α3 chain noncollagen 1 domain of type IV collagen (α3(IV)NC1) are a serological hallmark in the diagnosis of anti-glomerular basement membrane (GBM) disease. The objective of our study was to compare the performance of anti-glomerular basement membrane (GBM) antibody detection by chemiluminescence immunoassay (CIA) and by enzyme-linked immunosorbent assays (ELISAs). Sera from outpatients who were suspected to have anti-GBM disease and 31 patients with biopsy-proven anti-GBM disease were collected. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/0886022X.2019.1702056DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6968565PMC
November 2020

Concurrent treatment with rituximab and plasma exchange for severe refractory granulomatosis with polyangiitis: A case report.

Medicine (Baltimore) 2019 Dec;98(51):e18139

Department of Rheumatology, School of Medicine, Kyung Hee University, Seoul, South Korea.

Rationale: Rituximab is recommended to induce remission of severe granulomatosis with polyangiitis (GPA). Plasma exchange (PE) may be considered in the setting of rapidly progressive glomerulonephritis (RPGN) with a serum creatinine increase of more than 5.6 mg/dl or diffuse alveolar hemorrhage (DAH). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/MD.0000000000018139DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6940185PMC
December 2019

Do we care if you have a cat? Bartonella infection related glomerulonephritis with no endocarditis.

Infez Med 2019 12;27(4):441-444

Department of Hospital Medicine, Mount Carmel East Hospital, Columbus, OH, USA.

Bartonella infection has been associated with culture negative endocarditis and in rare cases immune complex medicated rapidly progressive glomerulonephritis (RPGN). Most of the previously reported cases of RPGN are associated with endocarditis. We report a case of RPGN with no endocarditis secondary to Bartonella infection. Read More

View Article

Download full-text PDF

Source
December 2019

Association between neutrophil-lymphocyte & platelet lymphocyte ratios with prognosis & mortality in rapidly progressive glomerulonephritis.

Indian J Med Res 2019 10;150(4):399-406

Division of Nephrology, Department of Medicine, University of Celal Bayar, Manisa, Turkey.

Background & Objectives: Rapidly progressive glomerulonephritis (RPGN) is a clinical syndrome manifested by features of nephritic syndrome and progressive loss of renal function over a short time. The objective of this study was to investigate the relationship between neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR) and prognostic factors and pathological findings of renal biopsy in RPGN.

Methods: Consecutive newly diagnosed RPGN patients who had follow up for at least six months were retrospectively analyzed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4103/ijmr.IJMR_1234_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6902366PMC
October 2019

Resolution of syphilis-related rapidly progressive glomerulonephritis with penicillin therapy: Case report
.

Clin Nephrol 2020 Feb;93(2):106-110

Renal manifestations of syphilis are variable, with membranous nephropathy being the most commonly described lesion. Rapidly progressive glomerulonephritis (RPGN) is rare and there is only one case report in the literature describing syphilis-associated crescentic glomerulonephritis. We report a rare case of RPGN secondary to latent syphilis, which resolved with penicillin treatment in the absence of immunosuppressive therapy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5414/CN109847DOI Listing
February 2020

endocarditis masquerading as systemic vasculitis with rapidly progressive glomerulonephritis (aka 'Löhlein nephritis').

BMJ Case Rep 2019 Dec 3;12(12). Epub 2019 Dec 3.

Internal Medicine H, Tel Aviv Ichilov-Sourasky Medical Center, Tel Aviv, Israel.

species are fastidious, Gram-negative aerobic rods and a well-recognised pathogen responsible for culture-negative endocarditis. The histopathological appearance of glomerulonephritis (GN) caused by endocarditis may include a pauci-immune GN similar to that usually seen in antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis. Herein, we present an unusual case report of endocarditis masquerading as ANCA-positive vasculitis, with crescentic GN. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bcr-2019-231413DOI Listing
December 2019

Proteinase 3-antineutrophil cytoplasmic antibody-positive necrotizing crescentic glomerulonephritis complicated by infectious endocarditis: a case report.

J Med Case Rep 2019 Dec 5;13(1):356. Epub 2019 Dec 5.

Division of Nephrology, First Department of Integrated Medicine, Saitama Medical Center, Jichi Medical University, 1-847 Amanuma-cho, Omiya-ku, Saitama, Saitama, 330-8503, Japan.

Background: Proteinase 3-antineutrophil cytoplasmic antibody has been reported to be positive in 5-10% of cases of renal injury complicated by infective endocarditis; however, histological findings have rarely been reported for these cases.

Case Presentation: A 71-year-old Japanese man with a history of aortic valve replacement developed rapidly progressive renal dysfunction with gross hematuria and proteinuria. Blood analysis showed a high proteinase 3-antineutrophil cytoplasmic antibody (163 IU/ml) titer. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13256-019-2287-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6894315PMC
December 2019

Molecular Analysis of Goodpasture's Disease Following Hematopoietic Stem Cell Transplant in a Pediatric Patient, Recalls the Conformeropathy of Wild-Type Anti-GBM Disease.

Front Immunol 2019 14;10:2659. Epub 2019 Nov 14.

Division of Nephrology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, United States.

Goodpasture's disease (GP) is mediated by autoantibodies that bind the glomerular and alveolar basement membrane, causing rapidly progressive glomerulonephritis with or without pulmonary hemorrhage. The autoantibodies bind neoepitopes formed upon disruption of the quaternary structure of α345NC1 hexamer, a critical structural domain of α345 collagen IV scaffolds. Hexamer disruption leads to a conformational changes that transitions α3 and α5NC1 subunits into immunogens, however, the trigger remains unknown. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fimmu.2019.02659DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6868084PMC
November 2019

[Review on anti-glomerular basement membrane disease or Goodpasture's syndrome].

Rev Med Interne 2020 Jan 24;41(1):14-20. Epub 2019 Nov 24.

Sorbonne Université, UPMC Université Paris 06, UMR 7211, and Inflammation-Immunopathology-Biotherapy Department (DHU i2B), 75005, Paris, France; Inserm, UMR_S 959, 75013, Paris, France; CNRS, FRE3632, 75005, Paris, France; Department of Internal Medicine and Clinical Immunology, AP-HP, Groupe Hospitalier Pitié-Salpêtrière, 75013, Paris, France; Centre de Référence des Maladies Auto-Immunes et Systémiques Rares, Centre de Référence des Maladies Auto-Inflammatoires et de l'Amylose, 94270 Le Kremlin Bicêtre, France.

Anti-glomerular basement membrane (anti-GBM) disease or Goodpasture's syndrome is a small vessel vasculitis affecting the capillary beds of kidneys and lungs. It is an autoimmune disease mediated by autoantibodies targeting the glomerular and alveolar basement membranes, leading to pneumorenal syndrome. It is a rare, monophasic and severe disease, associating rapidly progressive glomerulonephritis and alveolar hemorrhage. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.revmed.2019.10.338DOI Listing
January 2020

A Case of Granulomatosis with Polyangiitis (Wegener's Granulomatosis) Presenting with Rapidly Progressive Glomerulonephritis.

Cureus 2019 Oct 12;11(10):e5896. Epub 2019 Oct 12.

Family Medicine, Woodhaven Medical Professional Corporation, Queens Village, USA.

Granulomatosis with polyangiitis (GPA, Wegener's granulomatosis) presenting as rapidly progressive glomerulonephritis is not uncommon. The recognition of multisystem disease involving joints, kidney, and lung is critical for diagnosing Wegener's vasculitis. Here, we report a case study of a 52-year-old Bangladeshi man presented with a history of progressively worsening fever, recurrent cough, and hemoptysis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.7759/cureus.5896DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6839754PMC
October 2019

Acute tubulointerstitial nephritis with germinal centers in antineutrophil cytoplasmic antibody-associated vasculitis: A case report and literature review.

Medicine (Baltimore) 2019 Nov;98(48):e18178

Renal Division, Department of Medicine, Peking University First Hospital Institute of Nephrology, Peking University Renal Pathology Center, Institute of Nephrology, Peking University Key Laboratory of Renal Disease, Ministry of Health of China.

Rationale: Occasionally, tubulointerstitial lesions can be found in antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). However, significantly isolated tubulointerstitial nephritis (TIN) with germinal centers is rare.

Patient Concerns: A 17-year-old Chinese Han patient showed rapidly progressive glomerulonephritis, anuria, and serum creatinine of 19. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/MD.0000000000018178DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6890356PMC
November 2019

Plasma exchange in anti-glomerular basement membrane disease.

Presse Med 2019 Nov 5;48(11 Pt 2):328-337. Epub 2019 Nov 5.

Imperial College London, Hammersmith Campus, Department of Medicine, Du Cane Road, W12 0NN London, UK.

Anti-glomerular basement membrane (GBM) disease is a rare autoimmune vasculitis characterised by antibodies directed against the non collagenous (NC1) domain of the α3 chain of type 4 collagen (α3(IV)NC1). Clinical features are typically of a rapidly progressive glomerulonephritis (RPGN) with or without pulmonary haemorrhage. Treatment aims to rapidly remove circulating autoantibodies with plasma exchange and prevent further antibody production and suppress inflammation using immunosuppression and corticosteroids. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.lpm.2019.03.017DOI Listing
November 2019

Membranous nephropathy in a child with crescentic glomerulonephritis: Coincidence or comorbidity?

Saudi J Kidney Dis Transpl 2019 Sep-Oct;30(5):1156-1160

Department of Pediatrics, Pediatric Nephrology Units, Faculty of Medicine, Ege University, Izmir, Turkey.

Rapidly progressive glomerulonephritis (RPGN) is rare syndrome in children, characterized by clinical features of glomerulonephritis and rapid loss of renal function, and is associated with crescentic glomerulonephritis. Primary membranous nephropathy (MN) is an immune-complex-mediated cause of the adult nephrotic syndrome but occurs less frequently in children. RPGN is rarely observed in adults with primary MN. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4103/1319-2442.270273DOI Listing

Acute kidney injury associated with glomerular diseases.

Curr Opin Crit Care 2019 12;25(6):573-579

Nephrology and Dialysis Unit, Center of Research of Immunopathology and Rare Diseases (CMID), Coordinating Center of the Network for Rare Diseases of Piedmont and Aosta Valley, Department of Clinical and Biological Sciences, San Giovanni Hospital and University of Turin, Turin, Italy.

Purpose Of Review: This review focuses on acute kidney injury (AKI) associated with glomerular diseases and specifically the mechanisms of development of AKI in the wide spectrum of glomerulopathies.

Recent Findings: The immune system and the kidneys are closely linked. In healthy individuals, the kidneys contribute to immune homeostasis, whereas components of the immune system mediate many acute forms of kidney disease. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/MCC.0000000000000675DOI Listing
December 2019

[A Case of Early-Developing Rapidly Progressive Glomerulonephritis after Laparoscopic-Assisted Distal Gastrectomy for Gastric Cancer].

Gan To Kagaku Ryoho 2019 Oct;46(10):1626-1628

Dept. of Surgery, Yokohama City University.

This is a case of a 76-year-old man who had no significant past medical or family history. In the current medical history, in November 2017, upper gastrointestinal endoscopy showed a semicircular protruding lesion in the posterior wall of the gastric antrum, and gastric cancer was diagnosed following biopsy. Endoscopic submucosal dissection(ESD)was performed in the same year for the treatment of gastric cancer(cT1aN0M0). Read More

View Article

Download full-text PDF

Source
October 2019
1 Read

Clinicopathological features and prognostic analysis of 49 cases with crescentic glomerulonephritis.

Exp Ther Med 2019 Nov 18;18(5):3984-3990. Epub 2019 Sep 18.

Department of Nephrology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, P.R. China.

Rapidly progressive glomerulonephritis (RPGN), characterized by rapid kidney dysfunction caused by aggressive glomerulonephritis, is usually associated with crescentic glomerulonephritis (CrGN). In the present study, the data from patients with CrGN were retrospectively analyzed at a tertiary medical center in China with the aim of investigating the clinicopathological features and the association of the type of CrGN with the prognosis. The renal biopsies of 49 patients diagnosed with CrGN were obtained between December 2011 and July 2016. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3892/etm.2019.8023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6781789PMC
November 2019
1 Read

Sequential Therapy for Remission Induction in Severe Antineutrophil Cytoplasmic Autoantibody-Associated Glomerulonephritis.

Am J Nephrol 2019 8;50(5):386-391. Epub 2019 Oct 8.

Division of Renal Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA,

Background: The introduction of combination therapy with glucocorticoids (GC) and cyclophosphamide (CYC) or rituximab (RTX) has resulted in remission rates exceeding 90% in patients with antineutrophil cytoplasmic autoantibody (ANCA)-associated vasculitis (AAV). However, early treatment-related mortality remains a major concern and has driven the search for safer induction regimens exploring minimization or avoidance of GC and CYC. Most trials have excluded patients with severe renal disease. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000503318DOI Listing
October 2019
1 Read

Renal pathology and clinical associations in systemic sclerosis: a historical cohort study.

Int J Gen Med 2019 2;12:323-331. Epub 2019 Sep 2.

Department of Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.

Background: The information guiding the treatment decision(s) for renal diseases in systemic sclerosis (SSc) is the renal pathological finding. This study aimed to evaluate the renal pathological diagnosis and its clinical feature among SSc.

Method: A historical cohort study was performed on adult Thai SSc patients who underwent renal biopsy during January 2005-December 2016. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2147/IJGM.S221471DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6730604PMC
September 2019
2 Reads

The IgG-degrading enzyme of Streptococcus pyogenes causes rapid clearance of anti-glomerular basement membrane antibodies in patients with refractory anti-glomerular basement membrane disease.

Kidney Int 2019 Nov 1;96(5):1234-1238. Epub 2019 Aug 1.

Departments of Nephrology and Medical and Health Sciences, Linköping University, Linköping, Sweden.

In anti-glomerular basement membrane (anti-GBM) disease, IgG class autoantibodies induce rapidly progressive glomerulonephritis. Regrettably, many patients are diagnosed at a late stage when even intensive conventional treatment fails to restore renal function The endopeptidase IdeS (Immunoglobulin G degrading enzyme of Streptococcus pyogenes) (imliflidase) rapidly cleaves all human IgG subclasses into F(ab') and Fc fragments. We received permission to treat three patients with refractory anti-GBM nephritis without pulmonary involvement on a compassionate basis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.kint.2019.06.019DOI Listing
November 2019
2 Reads

CMV gastric ulcer in a patient with pauci immune crescentic glomerulonephritis on rituximab - a rare combination.

Postgrad Med 2019 Nov 17;131(8):619-622. Epub 2019 Sep 17.

Gastroenterology, Mercy St. Vincent Medical Center, Toledo, OH, USA.

Cytomegalovirus (CMV) infections are asymptomatic in immunocompetent patients but in immunocompromised patients, CMV infections have varying manifestations depending on their location. Patient who are organ transplant recipients, taking immunosuppressive therapy for a long time are at increased risk of CMV infections. CMV-induced gastric ulcer is very rare but many cases have been reported in the literature. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/00325481.2019.1667211DOI Listing
November 2019
4 Reads

Clinico-pathological considerations in a 48-years-old female with acute kidney injury: is it lupus nephritis, ANCA-associated vasculitis or something else?

BMC Nephrol 2019 08 27;20(1):334. Epub 2019 Aug 27.

Service de Néphrologie-Dialyse-Transplantation, Université d'Angers, CHU Angers, 4 rue Larrey, 49033 Angers CEDEX 09, Angers, France.

Background: The value of ANCA positivity in the setting of systemic lupus erythematous and their pathogenicity remains uncertain.

Case Presentation: We report the case of a 48-year-old female with rapidly progressive kidney failure, arthro-myalgia and weight loss. Auto-immune screening showed anti-dsDNA antibodies, complement consumption and triple ANCA positivity. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12882-019-1531-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6712693PMC
August 2019
3 Reads

Differences in clinicopathologic variables between Borrelia C6 antigen seroreactive and Borrelia C6 seronegative glomerulopathy in dogs.

J Vet Intern Med 2019 Sep 24;33(5):2096-2104. Epub 2019 Aug 24.

Department of Medicine and Epidemiology, University of California-Davis, Davis, California.

Background: Rapidly progressive glomerulonephritis has been described in dogs that seroreact to Borrelia burgdorferi, but no studies have compared clinicopathologic differences in Lyme-seroreactive dogs with protein-losing nephropathy (PLN) versus dogs with Borrelia-seronegative PLN.

Hypothesis/objectives: Dogs with Borrelia C6 antigen-seroreactive PLN have distinct clinicopathologic findings when compared to dogs with Borrelia seronegative PLN.

Animals: Forty dogs with PLN and Borrelia C6 antigen seroreactivity and 78 C6-seronegative temporally matched dogs with PLN. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/jvim.15586DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6766491PMC
September 2019
3 Reads

Microscopic polyangiitis masquerading as a pancreatic neoplasm with multiple lung metastases.

BMJ Case Rep 2019 Aug 20;12(8). Epub 2019 Aug 20.

Internal Medicine, South Miyagi Medical Center, Ogawara, Japan.

A 71-year-old man was admitted to our hospital with right lower abdominal pain. Blood analysis indicated severe inflammation, and abdominal CT revealed a pancreatic head tumour and multiple lung nodules. The level of a tumour marker was high. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bcr-2019-230356DOI Listing
August 2019
4 Reads