1,988 results match your criteria Glomerulonephritis Rapidly Progressive


[Metastatic Pulmonary Calcification: A Rare Entity in the Differential Diagnosis Examination of Interstitial Lung Diseases].

Pneumologie 2021 May 11. Epub 2021 May 11.

Institut für diagnostische und interventionelle Radiologie, Ammerlandklinik Westerstede.

A 70-year-old patient who received a kidney transplant about 20 years ago due to anti-neutrophil cytoplasmic antibody (ANCA)-positive, rapidly progressive glomerulonephritis was assigned to us for an evaluation of fibrosing interstitial lung disease with computer tomography (CT)-radiological changes assigned to acute alveolitis. She complained about long-term exertional dyspnea. In terms of lung function, there was some slight restriction (FVC 78 % of the target), and pronounced severe diffusion disorder (DLCO 41 % of the target). Read More

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A Rare Case of Double Antibody-Positive Rapidly Progressive Glomerulonephritis: A Therapeutic Challenge.

J Investig Med High Impact Case Rep 2021 Jan-Dec;9:23247096211013193

Florida State University, Sarasota, FL, USA.

Crescentic glomerulonephritis, also known as rapidly progressive glomerulonephritis, is a syndrome characterized by progressive and rapid deterioration of renal function over the course of weeks to months. Oliguria, hematuria, azotemia, and hypertension are characteristic features of this condition. Crescentic glomerulonephritis is further classified according to the staining pattern on immunofluorescence. Read More

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T cell plasticity in renal autoimmune disease.

Cell Tissue Res 2021 May 3. Epub 2021 May 3.

I. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

The presence of immune cells is a morphological hallmark of rapidly progressive glomerulonephritis, a disease group that includes anti-glomerular basement membrane glomerulonephritis, lupus nephritis, and anti-neutrophil cytoplasmic antibody (ANCA)-associated glomerulonephritis. The cellular infiltrates include cells from both the innate and the adaptive immune responses. The latter includes CD4 and CD8 T cells. Read More

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Anti-glomerular basement membrane disease mediated by IgG and IgA: a case report.

Ren Fail 2021 Dec;43(1):774-778

Department of Nephrology, China-Japan Friendship Hospital, Beijing, People's Republic of China.

Background: Anti-glomerular basement membrane (anti-GBM) disease is a rare autoimmune condition responsible for rapidly progressive glomerulonephritis. This disease is usually mediated by IgG autoantibodies against the noncollagenous domain of the α3(IV) collagen chain. In rare cases, IgA or IgM anti-GBM antibodies are involved. Read More

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December 2021

Characterization of a Rat Model of Myeloperoxidase-Anti-Neutrophil Cytoplasmic Antibody-Associated Crescentic Glomerulonephritis.

Nephron 2021 Apr 28:1-17. Epub 2021 Apr 28.

Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Centro Anna Maria Astori, Science and Technology Park Kilometro Rosso, Bergamo, Italy.

Background/aim: Necrotizing crescentic glomerulonephritis (GN) associated with anti-neutrophil cytoplasmic antibodies (ANCA) against myeloperoxidase (MPO) is a devastating disease that quickly progresses to kidney failure. Current therapies are broadly immunosuppressive and associated with adverse effects. We wanted to set up a model that could be suitable for testing narrowly targeted therapies. Read More

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Acute Severe Renal Artery Stenosis Presenting as Acute Kidney Injury with Severe Hypertension, and Active Urine Sediment.

Can J Cardiol 2021 Apr 20. Epub 2021 Apr 20.

Division of Nephrology, Department of Medicine, The Ottawa Hospital, University of Ottawa. Electronic address:

We present a case of severe renal artery stenosis that mimicked a rapidly progressive glomerulonephritis with acute kidney injury, active urine sediments and severe hypertension. Simultaneous presence of secondary hyperaldosteronism and hypokalemia prompted renal angiogram and subsequent renal artery angioplasty and stenting, thus leading to rapid resolution of acute kidney injury, proteinuria, and hypertension. Our case emphasizes the importance and benefits of prompt diagnosis and revascularization of acute severe renal artery stenosis in a patient with history of atherosclerotic renovascular disease presenting with sudden onset of severe hypertension and acute kidney injury with active urine sediment mimicking rapidly progressive glomerulonephritis. Read More

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Anti-neutrophil cytoplasmic antibody associated glomerulonephritis complicating treatment with hydralazine.

Kidney Int 2021 Apr 20. Epub 2021 Apr 20.

Department of Pathology, Columbia University Irving Medical Center, New York, New York, USA.

Hydralazine, a widely used therapy for hypertension and heart failure, can elicit autoimmune disease, including anti-neutrophil cytoplasmic antibody associated glomerulonephritis (ANCA-GN). We identified 80 cases of ANCA-GN complicating treatment with hydralazine, accounting for 4.3% (80/1858 biopsies) of ANCA-GN diagnosed between 2006 and 2019. Read More

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Glomerular Immune Deposition in MPO-ANCA Associated Glomerulonephritis Is Associated With Poor Renal Survival.

Front Immunol 2021 25;12:625672. Epub 2021 Mar 25.

Department of Nephrology, Xiangya Hospital, Central South University, Changsha, China.

Background: Rapidly progressive glomerulonephritis caused by antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is typically characterized as pauci-immune glomerulonephritis. However, immune complex (IC) deposition in the glomerulus has been reported in a growing number of studies. Here, we assess the presence of glomerular immune deposits alongside renal outcome in myeloperoxidase (MPO)-ANCA associated glomerulonephritis (MPO-ANCA GN). Read More

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Early onset calciphylaxis following acute kidney injury secondary to anti-glomerular basement membrane antibody disease.

BMJ Case Rep 2021 Apr 7;14(4). Epub 2021 Apr 7.

Nephrology and Hypertension, Albany Medical Center Hospital, Albany, New York, USA.

Calciphylaxis is commonly associated with end-stage renal disease (ESRD) and renal transplant. We present a rare case of early onset calciphylaxis in a patient presenting with acute kidney injury (AKI) secondary to anti-glomerular basement membrane (anti-GBM) antibody disease. A 65-year-old obese Caucasian woman with type 2 diabetes mellitus and hypertension presented with a 1-month history of painless gross haematuria and worsening lower extremity oedema. Read More

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Histopathologic and clinicopathologic classifications of antineutrophil cytoplasmic antibody-associated glomerulonephritis: a validation study in a Korean cohort.

Kidney Res Clin Pract 2021 Mar 24;40(1):77-88. Epub 2021 Mar 24.

Department of Internal Medicine, School of Medicine, Kyungpook National University, Daegu, Republic of Korea.

Background: Antineutrophil cytoplasmic antibodies (ANCA)-associated glomerulonephritis (AAGN) is a common cause of rapidly progressive glomerulonephritis and requires prompt and proper immunosuppressive therapy to improve renal prognosis. This study aimed to evaluate the predictive value of two different classifications for renal outcomes in Korean AAGN patients.

Methods: Ninety-two patients who were diagnosed with AAGN at two tertiary hospitals between 2004 and 2018 were retrospectively analyzed retrospectively. Read More

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More difficult still: Treating severe rapidly progressive glomerulonephritis in the context of COVID-19 pneumonia.

Nefrologia 2021 Jan 28. Epub 2021 Jan 28.

Servicio de Nefrología, Hospital Universitario Infanta Leonor, Madrid, España.

We present the case of a male patient with severe SARS-CoV-2 pneumonia, with simultaneous onset of p-ANCA positive rapidly progressive glomerulonephritis. We discuss the different therapeutic possibilities, emphasising the appropriateness of their administration according to the time in the course of the infection. Read More

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January 2021

Glomerulonephritis in AKI: From Pathogenesis to Therapeutic Intervention.

Front Med (Lausanne) 2020 2;7:582272. Epub 2021 Mar 2.

Nephrology, Dialysis and Transplantation Unit, Department of Emergency and Organ Transplantation, University of Bari, Bari, Italy.

Acute kidney injury (AKI) is increasingly emerging as a global emergency. Sepsis, major surgery, and nephrotoxic drugs are the main causes of AKI in hospitalized patients. However, glomerulonephritis accounts for about 10% of AKI episodes in adults, mainly related to rapidly progressive glomerulonephritis resulting from granulomatous polyangiitis (GPA, Wegener granulomatosis), microscopic polyangiitis (MPA), and anti-glomerular basement membrane (GBM) disease. Read More

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Isolated deafness as a presenting symptom in granulomatosis with polyangiitis.

BMJ Case Rep 2021 Mar 16;14(3). Epub 2021 Mar 16.

Department of Rheumatology, NHS Forth Valley, Stirling, UK.

Granulomatosis with polyangiitis (GPA) is a rare small vessel vasculitis commonly affecting the lungs, upper respiratory tract and kidneys. It is an idiopathic condition but likely due to an autoimmune process, resulting in granulomatous lesions and glomerulonephritis. Upper respiratory tract involvement is commonly seen in patients with GPA. Read More

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Rapidly progressive IgA vasculitis-associated nephritis successfully treated with immunosuppressive therapy in an adolescent with chronic granulomatous disease.

CEN Case Rep 2021 Mar 8. Epub 2021 Mar 8.

Department of Nephrology and Dialysis, Hyogo Prefectural Amagasaki General Medical Center, 2-17-77 Higashinaniwa-cho, Amagasaki, Hyogo, 660-8550, Japan.

Chronic granulomatous disease (CGD) is a rare immunodeficiency disorder with genetic defects in the nicotinamide adenine dinucleotide phosphate (NADPH) oxidase complex in phagocytes, leading to recurrent severe infections and granuloma formation. Genitourinary involvement, including obstructive granulomas, infections, nephrotoxicity of anti-infective agents, and amyloidosis, is frequently observed in patients with CGD, whereas the clinical and pathological details of the less commonly reported glomerular disease remain obscure. Here, we report the case of a patient with CGD who developed rapidly progressive IgA vasculitis-associated nephritis (IgAVN) and review the literature on biopsy-proven glomerular diseases in patients with CGD. Read More

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SARS-CoV-2 infection and recurrence of anti-glomerular basement disease: a case report.

BMC Nephrol 2021 02 27;22(1):75. Epub 2021 Feb 27.

Department of Internal Medicine 3 (Nephrology and Dialysis), Feldkirch Academic Teaching Hospital, Carinagasse 47, A-6800, Feldkirch, Austria.

Background: Anti-glomerular basement membrane disease (GBM) disease is a rare autoimmune disease causing rapidly progressive glomerulonephritis and pulmonary haemorrhage. Recently, an association between COVID-19 and anti-glomerular basement membrane (anti-GBM) disease has been proposed. We report on a patient with recurrence of anti-GBM disease after SARS-CoV-2 infection. Read More

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February 2021

Pediatric double positive anti-glomerular basement membrane antibody and anti-neutrophil cytoplasmic antibody glomerulonephritis-A case report with review of literature.

J Clin Apher 2021 Feb 25. Epub 2021 Feb 25.

Children's Hospital Colorado, Aurora, Colorado, USA.

Anti-glomerular basement membrane (GBM) disease is a rarely described entity in the pediatric population, especially in those less than 3 years old. Even rarer, is double seropositive disease, consisting of anti-GBM antibody plus anti-neutrophil cytoplasmic antibodies. Both single and double antibody positive diseases are characterized by rapidly progressive glomerulonephritis, often without pulmonary involvement in the pediatric population. Read More

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February 2021

Anti-glomerular Basement Membrane Disease with Antiphospholipid Syndrome.

Intern Med 2021 Feb 22. Epub 2021 Feb 22.

Department of Nephrology, Nagasaki University Hospital, Japan.

A 48-year-old woman presented with a fever, microscopic hematuria, proteinuria, and rapid deterioration of the renal function. Pulmonary alveolar hemorrhaging and a high level of anti-glomerular basement membrane (GBM) antibodies (700 IU/mL) were observed. Based on her medical history and positive findings of serum lupus anticoagulant, anti-phospholipid antibody syndrome (APS) was suspected. Read More

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February 2021

Galactose-deficient IgA1 and nephritis-associated plasmin receptors as markers for IgA-dominant infection-related glomerulonephritis: A case report.

Medicine (Baltimore) 2021 Feb;100(5):e24460

Division of Nephrology and Hypertension, Department of Internal Medicine, St Marianna University School of Medicine, Kawasaki.

Rational: Immunoglobulin A (IgA) nephropathy is a common heterogeneous kidney disease. One of the causes of secondary immunoglobulin A nephropathy is infection-related glomerulonephritis (IRGN), however, its accurate diagnosis is difficult.

Patient Concerns: We report a rare case of an 82-year-old male presenting rapidly progressive glomerulonephritis. Read More

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February 2021

Slowly progressive anti-neutrophil cytoplasmic antibody-associated renal vasculitis: clinico-pathological characterization and outcome.

Clin Kidney J 2021 Jan 6;14(1):332-340. Epub 2020 Sep 6.

Department of Biomedical Experimental and Clinical Sciences "Mario Serio", University of Firenze, and Nephrology Unit, Meyer Children's Hospital, Firenze, Italy.

Background: Although rapidly progressive glomerulonephritis is the main renal phenotype of anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV), slow renal disease progression is sometimes observed. These forms have been rarely discussed; we analysed their prevalence, clinico-pathological characteristics and outcome.

Methods: We screened patients with microscopic  polyangiitis (MPA) and granulomatosis with polyangiitis followed at seven referral centres and selected those with estimated glomerular filtration rate (eGFR) reduction <50% over a 6-month period preceding diagnosis. Read More

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January 2021

Slo-Mo anti-neutrophil cytoplasmic antibody-associated renal vasculitis.

Clin Kidney J 2021 Jan 9;14(1):18-22. Epub 2020 Nov 9.

Department of Medicine, School of Medicine, IIS-Fundación Jiménez Diaz, Division of Nephrology and Hypertension, Universidad Autónoma de Madrid, Madrid, Spain.

Nephrologists are familiar with severe cases of anti-neutrophil cytoplasmic antibodies-associated vasculitis (AAV) presenting as rapidly progressive glomerulonephritis. However, less is known about AAV with slowly progressive renal involvement. While its existence is acknowledged in textbooks, much remains unknown regarding its relative frequency versus more aggressive cases as well as about the optimal therapeutic approach and response to therapy. Read More

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January 2021

Granulomatous interstitial nephritis in granulomatosis with polyangiitis mimicking leprosy: A case report.

J Family Med Prim Care 2020 Nov 30;9(11):5783-5786. Epub 2020 Nov 30.

Department of General Medicine, North Eastern Indira Gandhi Regional Institute of Health and Medical Sciences, Shillong.

Granulomatous polyangiitis (GPA) is a small vessel vasculitis commonly affecting the upper and lower respiratory tracts and kidneys. About 90% of the cases are associated with ANCA, namely, PR3-ANCA and MPO-ANCA. Herein, we describe a patient of GPA who presented with anasarca, sensory neuropathy, recurrent upper airway congestion, epistaxis, and rapidly progressive glomerulonephritis. Read More

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November 2020

Staphylococcus-induced glomerulonephritis: potential role for corticosteroids.

BMJ Case Rep 2021 Jan 27;14(1). Epub 2021 Jan 27.

Department of Nephrology, Centro Hospitalar e Universitario de Coimbra EPE, Coimbra, Portugal.

is a troublesome pathogen, responsible for a broad range of clinical manifestations, ranging from benign skin infections to life-threatening conditions such as endocarditis and osteomyelitis. The kidney can be affected through a rapidly progressive glomerulonephritis mediated by an inflammatory reaction against a superantigen deposited in the glomerulus during the infection's course. This glomerulopathy has a poor prognosis, often leading to chronically impaired kidney function, eventually progressing to end-stage renal disease. Read More

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January 2021

Anca-positive vasculitis with full-house nephropathy, an unusual association: a case report and review of literature.

J Bras Nefrol 2021 Jan 20. Epub 2021 Jan 20.

Universidad de Boyacá, Tunja, Colombia.

Rapidly progressive glomerulonephritis is a medical emergency, with mortality around 20%. It is characterized by crescent glomerulonephritis and progressive loss of kidney function, hematuria, and proteinuria. Its classification is given by immunofluorescence detection of antibodies against glomerular basement membrane (Anti-MBG), immunocomplexes, or pauci-immune pattern. Read More

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January 2021

An Unusual Presentation of Pauci-Immune Necrotizing Glomerulonephritis.

Cureus 2020 Dec 18;12(12):e12155. Epub 2020 Dec 18.

Internal Medicine, Dignity Health Medical Group, St. Joseph's Hospital and Medical Center, Phoenix, USA.

Renal-limited pauci-immune necrotizing glomerulonephritis presenting as acute encephalopathy is a rare occurrence. A 67-year-old Hispanic male presented to the hospital after being found down. He was found to have acute renal failure and high anion gap metabolic acidosis. Read More

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December 2020

Atypical anti-glomerular basement membrane disease complicated by methicillin-susceptible Staphylococcus aureus infection-related rapidly progressive glomerulonephritis: a case report and literature review.

CEN Case Rep 2021 Jan 18. Epub 2021 Jan 18.

Department of Nephrology, Asahikawa Red Cross Hospital, 1jo 1 chome, Akebono, Asahikawa, Hokkaido, Japan.

Atypical anti-glomerular basement membrane (GBM) disease, which is characterized by low levels of or negativity for anti-GBM antibodies in circulation but positivity in the kidney, has been recognized in this decade. However, a therapeutic strategy has not been established to date because its outcome is better than that of classic anti-GBM disease. This case report and literature review highlight atypical anti-GBM disease in infection-related rapidly progressive glomerulonephritis. Read More

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January 2021

A Case of Glomerulonephritis Caused by Bartonella spp. Infective Endocarditis: The Difficulty and Importance of Differentiation from Anti-neutrophil Cytoplasmic Antibody-related Rapidly Progressive Glomerulonephritis.

Intern Med 2021 Jan 15. Epub 2021 Jan 15.

Division of Nephrology, Department of Internal Medicine, Tokyo Saiseikai Central Hospital, Japan.

A 65-year-old man with valvular disorder presented to his physician because of widespread purpura in both lower extremities. Blood tests showed elevated serum creatinine levels and proteinase 3-anti-neutrophil cytoplasmic antibody (ANCA) with hematuria, suggesting ANCA-related rapidly progressive glomerulonephritis (RPGN). Although multiple blood cultures were negative, transthoracic echocardiography revealed warts in the valves, and a renal biopsy also showed findings of glomerular infiltration by mononuclear leukocytes and C3 deposition in the glomeruli, suggesting infection-related glomerulonephritis. Read More

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January 2021

The clinical and immunological features of the post-extracorporeal shock wave lithotripsy anti-glomerular basement membrane disease.

Ren Fail 2021 Dec;43(1):149-155

Renal Division, Peking University First Hospital, Beijing, China.

Introduction: Extracorporeal shock wave lithotripsy (ESWL) is a noninvasive modality to treat urolithiasis, with complications including tissue damage and hematoma of kidney parenchyma. Anti-glomerular basement membrane (GBM) disease is suggested to be a rare complication of ESWL since it was reported in several cases to occur after ESWL. However, the clinical and immunological features of the ESWL-associated anti-GBM disease have not been fully investigated so far. Read More

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December 2021

Bilateral Ureteral Stenosis with Hydronephrosis as First Manifestation of Granulomatosis with Polyangiitis (Wegener's Granulomatosis): A Case Report and Review of the Literature.

Case Rep Nephrol 2020 21;2020:7189497. Epub 2020 Dec 21.

Service of Nephrology, HFR Cantonal Hospital Fribourg, Fribourg, Switzerland.

Ureteral stenosis is a rare manifestation of granulomatosis with polyangiitis (formerly known as Wegener's granulomatosis). We report the case of a 76-year-old woman with progressive renal failure in which bilateral hydronephrosis due to ureteral stenosis was the first manifestation of the disease. Our patient also had renal involvement with pauci-immune crescentic glomerulonephritis associated with high titers of anti-proteinase 3 c-ANCAs, but no involvement of the upper or lower respiratory tract. Read More

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December 2020

Concurrent Anti-Glomerular Basement Antibody Disease and Membranous Nephropathy: A Case Series.

Am J Kidney Dis 2021 Jan 7. Epub 2021 Jan 7.

Division of Nephrology, Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY. Electronic address:

Rationale & Objective: Anti-glomerular basement membrane (GBM) disease is a rapidly progressive glomerulonephritis which, in some instances, occurs concurrently with other diseases such as antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis. Rarely, it also occurs with membranous nephropathy (MN). We report a series of such patients, characterizing their long-term follow up. Read More

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January 2021