53,178 results match your criteria Glomerulonephritis Poststreptococcal


Analysis of predictive factors for immunosuppressive response in anti-phospholipase A2 receptor antibody positive membranous nephropathy.

BMC Nephrol 2018 Dec 12;19(1):354. Epub 2018 Dec 12.

Division of Nephrology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 1, Shuaifuyan, Wangfujing St, Beijing, 100730, China.

Background: Serum anti-phospholipase A2 receptor (PLA2R) antibody was correlated with disease activity of membranous nephropathy(MN). The predictive value of antibody titer changes on immunosuppressive response remains unknown. We investigated predictive value of dynamic change of anti-PLA2R antibody and 24-h urine protein (24hUP) for clinical response of MN. Read More

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December 2018

A rare case of Alport syndrome, atypical hemolytic uremic syndrome and Pauci-immune crescentic glomerulonephritis.

BMC Nephrol 2018 Dec 12;19(1):355. Epub 2018 Dec 12.

Department of Pathology, Stanford University, Stanford, CA, USA.

Background: Renal thrombotic microangiopathy (TMA) is occasionally seen in biopsies with pauci-immune necrotizing crescentic glomerulonephritis (PCGN). Recent study indicated that the complement activation is more prominent in the ANCA-negative glomerulonephritis.

Case Presentation: We report a case of concurrent TMA and PCGN without ANCA positivity. Read More

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December 2018

MEditerranean FeVer ( MEFV ) gene mutations in glomerulonephritides: a clinicopathological study

Turk J Med Sci 2018 12 12;48(6):1182-1191. Epub 2018 Dec 12.

Department of Nephrology, Faculty of Medicine, Ankara University, Ankara, Turkey

Background/aim: The aim of this study is to determine the ME diterranean F e V er ( MEFV ) gene mutation carrier rate in patients with glomerulonephritis and to investigate the association between disease features and MEFV variants.

Materials And Methods: Medical records regarding clinical, laboratory, histopathological, and prognostic features of 200 adult patients with biopsy-proven glomerulonephritis were evaluated retrospectively. Exons 2 and 10 of the MEFV gene of each patient were sequenced by next-generation sequencing. Read More

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December 2018

Particularities of Renal Manifestations in Chronic Viral Hepatitis.

Curr Health Sci J 2015 Jul-Sep;41(3):227-232. Epub 2015 Mar 15.

Department of Nephrology, University of Medicine and Pharmacy of Craiova, Romania.

Introduction: Chronic viral hepatitis represent major health problems worldwide, with an evolution that is sometimes marked by a series of extrahepatic manifestations. Among these, kidney disease may occur, either as glomerulonephritis, and/or renal dysfunction.

Material And Methods: The purpose of this study was to achieve a complete assessment of the liver and kidney function in a series of patients diagnosed with chronic viral hepatitis, in order to identify a possible kidney disease in this context. Read More

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Isolated end-stage renal disease in Sjögren's syndrome due to immune complex mediated glomerulonephritis.

Oxf Med Case Reports 2018 Dec 4;2018(12):omy109. Epub 2018 Dec 4.

Department of Nephrology, NYU Langone Health, Brooklyn, NY, USA.

Renal involvement is an uncommon extra-glandular manifestation in Sjogren's syndrome (SS). We present the case of a young male who presented with nephrotic range proteinuria and advanced irreversible renal disease, with positive anti-Ro antibody (Ab) and antineutrophil cytoplasmic antibody (ANCA) with myeloperoxidase (MPO) specificity. He was initially treated with steroids for suspected ANCA vasculitis but treatment was discontinued as there was no response and renal biopsy revealed interstitial lymphocytic infiltrates, advanced glomerular disease with immune complex mediated glomerulonephritis more suspicious for SS. Read More

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December 2018

Treatment of fibrillary glomerulonephritis with use of repository corticotropin injections.

Clin Kidney J 2018 Dec 20;11(6):788-790. Epub 2018 Mar 20.

Department of Pathology, The Ohio State University Wexner Medical Center, OH, USA.

Fibrillary glomerulonephritis (FGN) is a rare idiopathic condition linked to malignancy, autoimmune disorders, monoclonal gammopathies and hepatitis C virus. It usually has a poor prognosis, resulting in progression to end-stage renal disease within a few years, given the lack of standardized treatment. Repository corticotrophin (RC) injections are approved for use in a variety of nephrotic syndromes, but are not routinely considered for treatment of FGN. Read More

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December 2018

Modulation of Macrophage Polarization by Human Glomerular Mesangial Cells in Response to the Stimuli in Renal Microenvironment.

J Interferon Cytokine Res 2018 Dec 5. Epub 2018 Dec 5.

1 Department of Nephrology, Chinese PLA General Hospital, Chinese PLA Institute of Nephrology , State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Beijing Key Laboratory for Kidney Diseases, Beijing, China .

Mesangial cell (MC) activation and macrophage infiltration are 2 major events closely related with each other in mesangial proliferative glomerulonephritis. In the anti-Thy 1 nephritis model, macrophages mediate the damage and also the expansion of mesangium through secreting various inflammatory factors; however, in glomerular microenvironment how MCs affect macrophage activity in the presence of various stimuli have not yet been understood. In the present study, we found that resting human MCs (HMCs) constitutively expressed chemokine [C-C motif] ligand 2 (CCL-2) and interleukin (IL)-6 and induced M2 polarization of macrophages in the coculture system. Read More

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December 2018

Platelet retention in inflamed glomeruli occurs via selective prolongation of interactions with immune cells.

Kidney Int 2018 Nov 29. Epub 2018 Nov 29.

Centre for Inflammatory Diseases, Monash University Department of Medicine, Monash Medical Centre, Clayton, Victoria, Australia. Electronic address:

Platelet-leukocyte interactions promote acute glomerulonephritis. However, neither the nature of the interactions between platelets and immune cells nor the capacity of platelets to promote leukocyte activation has been characterized in this condition. We used confocal intravital microscopy to define the interactions of platelets with neutrophils, monocytes, and endothelial cells in glomerular capillaries in mice. Read More

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November 2018

Activation of fibroblastic reticular cells in kidney lymph node during crescentic glomerulonephritis.

Kidney Int 2018 Nov 29. Epub 2018 Nov 29.

Transplantation Research Center, Brigham and Women's Hospital, Boston, Massachusetts, USA; Division of Renal Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA. Electronic address:

Crescentic glomerulonephritis is an inflammatory condition characterized by rapid deterioration of kidney function. Previous studies of crescentic glomerulonephritis have focused on immune activation in the kidney. However, the role of fibroblastic reticular cells, which reside in the stromal compartment of the kidney lymph node, has not been studied in this condition. Read More

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November 2018

Elevated Levels of Urinary Extracellular Vesicle Fibroblast-Specific Protein 1 in Patients with Active Crescentic Glomerulonephritis.

Nephron 2018 Dec 12:1-11. Epub 2018 Dec 12.

Department of Nephrology, Faculty of Medical Sciences, University of Fukui, Fukui, Japan.

Background/aims: Extracellular vesicles (EVs), including exosomes, are present in various bodily fluids, including urine. We and others previously reported that cells expressing fibroblast-specific protein 1 (FSP1) accumulate within damaged glomeruli, and that urinary FSP1, as well as urinary soluble CD163, could potentially serve as a biomarker of ongoing glomerular injury.

Methods: To test that idea, we collected urine samples from 37 patients with glomerular disease; purified the urinary EVs; characterized them using Nanosight, western blotting, and immunoelectron microscopy; and determined FSP1 and soluble CD163 levels using enzyme-linked immunosorbent assays. Read More

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December 2018

Antineutrophil cytoplasmic antibody-associated vasculitis, update on molecular pathogenesis, diagnosis, and treatment.

Int J Nephrol Renovasc Dis 2018 22;11:313-319. Epub 2018 Nov 22.

Department of Medicine, Division of Nephrology, UCLA David Geffen School of Medicine, Los Angeles, CA, USA,

Circulating antineutrophil cytoplasmic antibodies (ANCAs) are the central pathogenic mechanism for a group of systemic and renal syndromes called the ANCA-associated vasculitis (AAV). The nomenclature has changed from eponymous labeling to granulomatosis with polyangiitis, eosinophilic granulomatosis with polyangiitis, and microscopic polyangiitis. These syndromes predominantly affect the pulmonary and renal systems. Read More

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November 2018

Inflammasomes in the Kidney.

Exp Suppl 2018 ;108:177-210

Centre for Inflammatory Diseases, Monash University Department of Medicine, Monash Medical Centre, Clayton, VIC, Australia.

Inflammasomes influence a diverse range of kidney disease, including acute and chronic kidney diseases, and those mediated by innate and adaptive immunity. Both IL-18 and in particular IL-1β are validated therapeutic targets in several kidney diseases. In addition to leukocyte-derived inflammasomes, renal tissue cells express functional inflammasome components. Read More

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January 2018
1 Read

Investigations in systemic vasculitis - The role of renal pathology.

Best Pract Res Clin Rheumatol 2018 02 17;32(1):83-93. Epub 2018 Nov 17.

Department of Pathology, Leiden University Medical Center, Leiden, the Netherlands. Electronic address:

ANCA-associated vasculitis (AAV) describes a group of small-vessel vasculitides with frequent renal involvement. The first description of these conditions can be traced back to the 19th-century paper on necrotizing vasculitis by Kussmaul and Maier. Since then, our understanding of the pathogenesis has improved and the histopathological lesions have been described in detail. Read More

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February 2018

Potential Blood Pressure Goals in IgA Nephropathy: Prevalence, Awareness, and Treatment Rates in Chronic Kidney Disease Among Patients with Hypertension in China (PATRIOTIC) Study.

Kidney Blood Press Res 2018 Nov 30;43(6):1786-1795. Epub 2018 Nov 30.

Background/aims: IgA nephropathy is the most prevalent form of primary glomerulonephritis worldwide. Among patients with kidney disease, hypertension is one of the most important risk factors of disease progression. Considering the limited evidence regarding the appropriate blood pressure (BP) goal for patients with IgA nephropathy, our aim was to critically appraise the potential BP goal in IgA nephropathy. Read More

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November 2018
1 Read

[Tubulointerstitiel nephritis and Crohn's disease, nephrotoxicity or extraintestinal manifestation of Crohn's disease? About a case].

Nephrol Ther 2018 Nov 29. Epub 2018 Nov 29.

Laboratoire d'anatomie pathologique, CHRU de Nancy, 5, rue de Morvan, 54500 Vandœuvre-lès-Nancy, France.

Extraintestinal manifestations in inflammatory bowel disease involve most frequently the joints, the skin, the eyes, the liver and the biliary tract. Renal involvement is rare, and manifested as nephrolithiasis, tubulointerstitial nephritis, glomerulonephritis and amyloidosis. In patients with inflammatory bowel disease, renal disease is most frequently due to treatment nephrotoxicity and rarely as a guenine extraintestinal manifestation of inflammatory bowel disease. Read More

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November 2018
1 Read

Kidney transplantation in systemic lupus erythematosus: Outcomes and prognosis.

Med Clin (Barc) 2018 Nov 27. Epub 2018 Nov 27.

Servicio de Nefrología, Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), Hospital Universitario Ramón y Cajal, Madrid, España; Red de Investigación Renal (REDinREN), Madrid, España.

Introduction: The outcome and prognosis of systemic lupus erythematosus (SLE) in long-term kidney transplantation (KT) is variable. The objective of this study was to analyse the survival of the graft and the patient, comparing rates with a control group (primary glomerulonephritis [PGN]).

Materials And Methods: Forty-three patients receiving a KT with diagnosis of lupus nephritis (LN) and 367 patients with PGN were compared between January 1980 and December 2014. Read More

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November 2018
1 Read

Upregulated microRNAs in membranous glomerulonephropathy are associated with significant downregulation of IL6 and MYC mRNAs.

J Cell Physiol 2018 Dec 4. Epub 2018 Dec 4.

Section of Biology and Genetics Giovanni Sichel, Department of Biomedical and Biotechnological Sciences, University of Catania, Catania, Italy.

Membranous glomerulonephropathy (MGN) is a glomerulopathy characterized by subepithelial deposits of immune complexes on the extracapillary side of the glomerular basement membrane. Insertion of C5b-9 (complement membrane-attack complex) into the membrane leads to functional impairment of the glomerular capillary wall. Knowledge of the molecular pathogenesis of MGN is actually scanty. Read More

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December 2018
1 Read

How do lupus glomerulonephritis and its treatment affect the renal reserve?

Int Urol Nephrol 2018 Dec 4. Epub 2018 Dec 4.

Human Physiology Department, Instituto Universitario del Hospital Italiano de Buenos Aires, Buenos Aires, Argentina.

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December 2018
3 Reads

Recurrent glomerulonephritis following renal transplantation and impact on graft survival.

BMC Nephrol 2018 Dec 3;19(1):344. Epub 2018 Dec 3.

Department of Renal Medicine, The Canberra Hospital, PO Box 11, Woden, Canberra, ACT 2605, Australia.

Background: Recurrence of primary glomerulonephritis in the post-transplant period has been described in the literature but the risk remains poorly quantified and its impact on allograft outcomes and implications for subsequent transplants remain under-examined. Here we describe the rates and timing of post-transplant glomerulonephritis recurrence for IgA nephropathy, focal segmental glomerulosclerosis, mesangiocapillary GN and membranous GN based on 28 years of ANZDATA registry transplant data.

Methods: We investigated the rates of GN recurrence and subsequent graft outcomes in 7236 patient from 28 years of ANZDATA transplant registry data. Read More

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December 2018
4 Reads

Membranous glomerulonephritis - a common, unspecific pattern of glomerular injury.

Pol J Pathol 2018 ;69(3):209-218

Membranous nephropathy (MN) is a chronic form of glomerulonephritis, associated with the presence of immune complexes beneath the podocytes on the subepithelial region of glomerular capillaries. MN is not a disease entity but one of relatively common patterns of glomerular injury that may be a manifestation of primary renal autoimmunological reaction or may evolve as a phenomenon secondary to wide spectrum of systemic processes. Read More

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January 2018
3 Reads

IgG4-related kidney disease and retroperitoneal fibrosis: An update.

Mod Rheumatol 2018 Nov 30:1-24. Epub 2018 Nov 30.

c Division of Nephrology and Rheumatology, Department of Internal Medicine, Faculty of Medicine , Fukuoka University , Fukuoka , Japan.

The most representative kidney lesion of IgG4-related disease (IgG4-RD) is plasma cell-rich tubulointerstitial nephritis (TIN) with distinctive imaging findings including multiple low-density lesions on contrast-enhanced computed tomography. In addition, membranous glomerulonephritis is a representative glomerular lesion of this disease. Recent advances have clarified that inflammation with IgG4-positive plasma cell infiltrates is not restricted to the renal parenchyma, but can be seen in outside the renal capsule, around medium-sized arteries such as lobar arteries, around nerves, and in the renal pelvis and periureter. Read More

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November 2018
5 Reads

Precocious expression of Blimp1 in B cells causes autoimmune disease with increased self-reactive plasma cells.

EMBO J 2018 Nov 29. Epub 2018 Nov 29.

Research Institute of Molecular Pathology (IMP), Vienna Biocenter (VBC), Vienna, Austria

The transcription factor Blimp1 is not only an essential regulator of plasma cells, but also a risk factor for the development of autoimmune disease in humans. Here, we demonstrate in the mouse that the (Blimp1) gene was partially activated at the chromatin and transcription level in early B cell development, although mature mRNA did not accumulate due to posttranscriptional regulation. By analyzing a mouse model that facilitated ectopic Blimp1 protein expression throughout B lymphopoiesis, we could demonstrate that Blimp1 impaired B cell development by interfering with the B cell gene expression program, while leading to an increased abundance of plasma cells by promoting premature plasmablast differentiation of immature and mature B cells. Read More

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November 2018
1 Read

The association of hepatitis C infection with the onset of CKD and progression into ESRD.

Semin Dial 2018 Nov 29. Epub 2018 Nov 29.

Division of Nephrology, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts.

Hepatitis C virus (HCV) infection is not only an important cause of chronic liver disease, but extrahepatic manifestations are common and include chronic kidney disease (CKD). HCV is classically associated with cryoglobulinemic glomerulonephritis in the context of mixed cryoglobulinemia syndrome, but other glomerular diseases also occur and may be significantly under-recognized. HCV may cause glomerular disease by immune complex deposition; however, other potential mechanisms by which HCV promotes CKD include a direct cytopathic effect of the virus on renal tissue, and by its association with accelerated atherosclerosis, insulin resistance, and chronic inflammation. Read More

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November 2018
5 Reads

Unraveling the Molecular Mechanisms Underlying Complement Dysregulation by Nephritic Factors in C3G and IC-MPGN.

Front Immunol 2018 15;9:2329. Epub 2018 Oct 15.

Clinical Research Center for Rare Diseases Aldo e Cele Daccò and Centro Anna Maria Astori, Science and Technology Park Kilometro Rosso, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Bergamo, Italy.

Membranoproliferative glomerulonephritis (MPGN) was recently classified as C3 glomerulopathies (C3G), and immune-complex (IC) mediated MPGN. Dysregulation of the complement alternative pathway, driven by acquired and/or genetic defects, plays a pathogenetic role in C3G. However, alternative pathway abnormalities were also found in IC-MPGN. Read More

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October 2018
1 Read

Changes in the diagnosis of glomerular diseases in east China: a 15-year renal biopsy study.

Ren Fail 2018 Nov;40(1):657-664

a Kidney Disease Centre, The First Affiliated Hospital , Zhejiang University School of Medicine , Hangzhou , China.

Background: There have been some gradual changes in the distribution of renal biopsy pathological diagnoses during recent years. This study aimed to show changes in renal disease prevalence in China by investigating 10 patients diagnosed at our Kidney Disease Centre during the last 15 years.

Methods And Results: All patients aged 15-year-old or older who underwent renal biopsy at the First Affiliated Hospital, Zhejiang University, from 2001 to 2015 were enrolled. Read More

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November 2018
1 Read

Sex-specific analysis of haemodialysis prevalence, practices and mortality over time: the Austrian Dialysis Registry from 1965 to 2014.

Nephrol Dial Transplant 2018 Nov 21. Epub 2018 Nov 21.

Clinical Division of Nephrology and Dialysis, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria.

Background: Despite a higher prevalence of chronic kidney disease among women, more men than women start renal replacement therapy (RRT). We hypothesized that gender differences in health care access exist and therefore aimed at determining whether characteristics and outcomes of haemodialysis patients over time differ by sex.

Methods: We studied all 28 323 adults who began haemodialysis during 1965-2014 in the Austrian Dialysis Registry, analysing trends in patient characteristics by sex and decade with mortality (via Cox regression), which was compared with the mortality of the Austrian general population. Read More

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November 2018
3 Reads

Efficacy of Chinese herb Cistanche Yishen granules in treatment of tinnitus for patients with chronic nephritis.

J Cell Biochem 2018 Nov 26. Epub 2018 Nov 26.

Department of Nephrology, Jiangsu Province Hospital of TCM, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China.

Objective: This study aimed to investigate the efficacy of Chinese herb Cistanche Yishen granules (CYG) in the treatment of tinnitus for patients with chronic nephritis.

Methods: A total of 89 adult patients were diagnosed with chronic glomerulonephritis from January 2016 to December 2017. All the patients were randomly divided into two groups, such as the control group and the CYG group. Read More

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November 2018
1 Read
3.263 Impact Factor

Risk factors for graft loss in kidney transplant recipients with g3 glomerulitis: A single-center experience
.

Clin Nephrol 2018 Nov 26. Epub 2018 Nov 26.

Background: Risk factors for graft loss in kidney transplant recipients with g3 lesions are poorly defined.

Materials And Methods: We evaluated outcomes in 37 consecutive kidney transplant biopsies diagnosed with g3 glomerulitis based on Banff 2013 criteria in a single-center observational study.

Results: The diagnosis of g3 glomerulonephritis was made 6. Read More

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November 2018
3 Reads

Corticosteroid therapy alone for the treatment of C3 glomerulonephritis in association with monoclonal gammopathy
.

Clin Nephrol 2018 Nov 26. Epub 2018 Nov 26.

Introduction: C3 glomerulonephritis (C3GN) is a form of proliferative glomerulonephritis characterized by dominant glomerular C3 deposition. There is currently no consensus guideline on therapy for this disease. Experience with corticosteroids alone is scant in C3GN. Read More

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November 2018
1 Read

Predictors of Renal Outcomes in Sclerotic Class Anti-Neutrophil Cytoplasmic Antibody Glomerulonephritis.

Am J Nephrol 2018 23;48(6):465-471. Epub 2018 Nov 23.

Johns Hopkins University, Baltimore, Maryland, USA.

Background: The prognostic value of the anti-neutrophil cytoplasmic antibody (ANCA) associated glomerulonephritis (GN) classification has been demonstrated in several cohorts with sclerotic class having the worst renal outcome. Relevant published data on factors predicting outcomes in sclerotic ANCA GN is limited.

Methods: Sclerotic ANCA GN patients were recruited from 5 centers worldwide for this retrospective cohort study. Read More

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November 2018
3 Reads

Extracellular traps in kidney disease.

Kidney Int 2018 Dec;94(6):1087-1098

Division of Nephrology, Medizinische Klinik und Poliklinik IV, Klinikum der Universität München, LMU München, Germany. Electronic address:

During the past decade the formation of neutrophil extracellular traps (NETs) has been recognized as a unique modality of pathogen fixation (sticky extracellular chromatin) and pathogen killing (cytotoxic histones and proteases) during host defense, as well as collateral tissue damage. Numerous other triggers induce NET formation in multiple forms of sterile inflammation, including thrombosis, gout, obstruction of draining ducts, and trauma. Whether neutrophils always die along with NET release, and if they do die, how, remains under study and is most likely context dependent. Read More

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December 2018
4 Reads

Correlation between Pathological Findings and the Usefulness of Clinical Guidelines for the Treatment of ANCA-Positive RPGN: A Retrospective Analysis.

J Nippon Med Sch 2018 ;85(5):259-264

Department of Nephrology, Nippon Medical School.

Background: The physical condition of patients with anti-neutrophil cytoplasmic antibody (ANCA)-associated rapidly progressive glomerulonephritis (RPGN) is at times too critical for physicians to undertake a renal biopsy. In such cases, physicians need to start treatments without determining the pathological features of the disease. However, the prevalent clinical practice guidelines for ANCA-associated RPGN in Japan do not necessitate the pathological findings in a renal biopsy for determining first-line treatments. Read More

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January 2018
3 Reads

Renal dysfunction in Leishmaniasis and Chagas disease coinfection: a case report.

Rev Inst Med Trop Sao Paulo 2018 Nov 14;60:e73. Epub 2018 Nov 14.

Universidade Federal do Ceará, Faculdade de Medicina, Fortaleza, Ceará, Brazil.

Visceral leishmaniasis (VL) is an endemic parasitic disease frequently found in Northeast Brazil and may cause acute kidney injury (AKI) and glomerulonephritis. After appropriate treatment, renal function recovery may occur. We describe the rare case of a patient with VL, who developed severe AKI requiring dialysis and was subsequently diagnosed with Chagas disease coinfection. Read More

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November 2018
1 Read

Early growth response protein 1 upregulates long noncoding RNA Arid2-IR to promote extracellular matrix production in diabetic kidney disease.

Am J Physiol Cell Physiol 2018 Nov 21. Epub 2018 Nov 21.

Department of Endocrinology & Metabolism, Nanfang Hospital, Southern Medical University, China.

Diabetic kidney disease (DKD) has surpassed chronic glomerulonephritis as the leading cause of end-stage renal disease (ESRD). Previously, we showed that early growth response protein 1 (Egr1) plays a key role in DKD by enhancing mesangial cell proliferation and extracellular matrix (ECM) production. The long noncoding RNA Arid2-IR has been identified as a Smad3-associated lncRNA in unilateral ureteral obstructive (UUO) kidney disease. Read More

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November 2018
2 Reads
3.780 Impact Factor

Modulation of the microbiota by oral antibiotics treats immunoglobulin A nephropathy in humanized mice.

Nephrol Dial Transplant 2018 Nov 20. Epub 2018 Nov 20.

INSERM 1149, Center for Research on Inflammation (CRI), Paris, France.

Background: Immunoglobulin A nephropathy (IgAN) is the most common primary glomerulonephritis worldwide. IgA is mainly produced by the gut-associated lymphoid tissue (GALT). Both experimental and clinical data suggest a role of the gut microbiota in this disease. Read More

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November 2018
5 Reads

Expression of DENDRIN in several glomerular diseases and correlation to pathological parameters and renal failure - preliminary study.

Diagn Pathol 2018 Nov 20;13(1):90. Epub 2018 Nov 20.

Department of Pathology, Forensic medicine and Cytology, University Hospital Centre Split, Split, Croatia.

Background: In glomerular injury dendrin translocates from the slit diaphragm to the podocyte nucleus, inducing apoptosis. We analyzed dendrin expression in IgA glomerulonephritis and Henoch Schönlein purpura (IgAN/HSP) versus in podocytopathies minimal change disease (MCD) and focal segmental glomerulosclerosis (FSGS), and compared it to pathohistological findings and renal function at the time of biopsy and the last follow-up.

Methods: Twenty males and 13 females with median of age 35 years (min-max: 3-76) who underwent percutaneous renal biopsy and had diagnosis of glomerular disease (GD) were included in this retrospective study. Read More

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November 2018
25 Reads

LncRNAs expression in adriamycin-induced rats reveals the potential role of LncRNAs contributing to chronic glomerulonephritis pathogenesis.

Gene 2018 Nov 17;687:90-98. Epub 2018 Nov 17.

Department of Pharmacy, The first Affiliated Hospital of Anhui University of Chinese Medicine, 117 Meishan Road, Hefei, China.

Background: Chronic glomerulonephritis (CGN) is the most common form of primary glomerular disease with unclear molecular mechanisms. Currently, limited study on long non-coding RNAs (lncRNAs) in CGN is available. Our study aimed to identify potential lncRNAs and genes in the normal and adriamycin-induced CGN rats, which to explore the potential molecular mechanisms of CGN pathogenesis. Read More

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November 2018
2 Reads

International comparison of trends in patients commencing renal replacement therapy by primary renal disease.

Nephrology (Carlton) 2018 Nov 19. Epub 2018 Nov 19.

ERA-EDTA Registry, Department of Medical Informatics, Academic Medical Center, Amsterdam Public Health Research Institute, Amsterdam, The Netherlands.

Aim: To examine international time trends in the incidence of renal replacement therapy (RRT) for end-stage renal disease (ESRD) by primary renal disease (PRD).

Methods: Renal registries reporting on patients starting RRT per million population for ESRD by PRD from 2005 to 2014, were identified by internet search and literature review. The average annual percentage change (AAPC) with a 95% confidence interval (CI) of the time trends was computed using Joinpoint regression. Read More

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November 2018
2 Reads

Idiopathic membranoproliferative glomerulonephritis treated with mycophenolate mofetil.

Clin Case Rep 2018 Nov 23;6(11):2287-2288. Epub 2018 Sep 23.

Division of Pathology, Immunology and Laboratory Medicine University of Florida Gainesville Florida.

Idiopathic" membranoproliferative glomerulonephritis (MPGN) is rare compared to secondary forms and usually a progressive disease. Studies evaluating the role of steroids were primarily done in children, and the data are sparse in adults. Mycophenolate mofetil is effective and can be used as a steroid-sparing agent in the treatment of idiopathicMPGN. Read More

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November 2018
7 Reads

Membranous or membranous-like GN: A case report of massive proteinuria, positive serum with negative PLA2R on biopsy.

Clin Case Rep 2018 Nov 9;6(11):2198-2201. Epub 2018 Oct 9.

Department of Pathology Penn State Milton S. Hershey Medical Centre Hershey Pennsylvania.

This case report represents primary membranous glomerulonephritis (MGN) with positive serum anti-PLA2R antibodies, 2+ positivity for IgG4 on immunofluorescence with routine fresh-frozen sections and negative PLA2R stain on biopsy. He was treated as primary MGN based on positive serum PLA2R and the absence of clinical symptoms or signs suggestive of any secondary MGN. Read More

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November 2018
2 Reads

Infection-Related Glomerulonephritis.

Pediatr Clin North Am 2019 Feb;66(1):59-72

Division of Nephrology, Boston Children's Hospital, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA.

Acute postinfectious glomerulonephritis or infection-related glomerulonephritis has been associated with several viral or bacterial infections. Group A beta-hemolytic streptococcal infection is the prototypical cause of postinfectious glomerulonephritis and the main focus of this discussion. The clinical spectrum can vary widely, from asymptomatic microscopic hematuria incidentally detected on routine urinalysis to rapidly progressive glomerulonephritis with acute kidney injury requiring emergent dialysis. Read More

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February 2019
2 Reads

Approach to the Child with Hematuria.

Pediatr Clin North Am 2019 Feb;66(1):15-30

Pediatric Nephrology, Children's Hospital at Montefiore, Albert Einstein College of Medicine, 3415 Bainbridge Avenue, Bronx, NY 10467, USA. Electronic address:

The causes of macroscopic and microscopic hematuria overlap; both are often caused by urinary tract infections or urethral/bladder irritation. Coexistent hypertension and proteinuria should prompt investigation for glomerular disease. The most common glomerulonephritis in children is postinfectious glomerulonephritis. Read More

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February 2019
2 Reads

The role of eicosanoids in renal diseases - potential therapeutic possibilities.

Acta Biochim Pol 2018 11 19. Epub 2018 Nov 19.

Pomeranian Medical University, Department of Nephrology, Transplantology and Internal Medicine.

Eicosanoids are biologically active molecules that are created in the process of oxidation of arachidonic acid (AA) which is a constituent of the cell membrane phospholipids. Throughout the years it was evidenced by experiments that the lipid and lipid-derived metabolites play an important role in physiological and pathological processes in the kidneys. They are being considered as biomarkers in detecting acute kidney injury, nephrotoxicity, glomerulonephritis and early stages of diabetic nephropathy because of their participation in inflammatory processes and in oxidative stress. Read More

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November 2018
4 Reads

An Efficient Sieving Method to Isolate Intact Glomeruli from Adult Rat Kidney.

J Vis Exp 2018 Nov 1(141). Epub 2018 Nov 1.

Division of Renal-Electrolyte, Department of Medicine, University of Pittsburgh;

Preservation of glomerular structure and function is pivotal in the prevention of glomerulonephritis, a category of kidney disease characterized by proteinuria which can eventually lead to chronic and end-stage renal disease. The glomerulus is a complex apparatus responsible for the filtration of plasma from the body. In disease, structural integrity is lost and allows for the abnormal leakage of plasma contents into the urine. Read More

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November 2018
3 Reads

Clinical Characteristics and Treatment Patterns of Children and Adults With IgA Nephropathy or IgA Vasculitis: Findings From the CureGN Study.

Kidney Int Rep 2018 Nov 3;3(6):1373-1384. Epub 2018 Aug 3.

Department of Medicine, Division of Nephrology, Columbia University College of Physicians and Surgeons, New York, New York, USA.

Introduction: The Cure Glomerulonephropathy Network (CureGN) is a 66-center longitudinal observational study of patients with biopsy-confirmed minimal change disease, focal segmental glomerulosclerosis, membranous nephropathy, or IgA nephropathy (IgAN), including IgA vasculitis (IgAV). This study describes the clinical characteristics and treatment patterns in the IgA cohort, including comparisons between IgAN versus IgAV and adult versus pediatric patients.

Methods: Patients with a diagnostic kidney biopsy within 5 years of screening were eligible to join CureGN. Read More

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November 2018
6 Reads

Paraffin Immunofluorescence: A Valuable Ancillary Technique in Renal Pathology.

Kidney Int Rep 2018 Nov 7;3(6):1260-1266. Epub 2018 Jul 7.

Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.

Immunofluorescence on frozen tissue is the gold standard immunohistochemical technique for evaluation of immune deposits in the kidney. When frozen tissue is not available or lacks glomeruli, immunofluorescence can be performed on paraffin tissue after antigen retrieval (paraffin immunofluorescence). Excellent results can be obtained by paraffin immunofluorescence in most immune complex-mediated glomerulonephritides and dysproteinemia-associated kidney lesions, and thus this technique has become a valuable salvage technique in renal pathology. Read More

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November 2018
11 Reads

Mechanisms and functions of IL-17 signaling in renal autoimmune diseases.

Mol Immunol 2018 Dec 15;104:90-99. Epub 2018 Nov 15.

III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Section of Translational Immunology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. Electronic address:

Immune-mediated glomerular diseases (glomerulonephritis) encompass a heterogeneous collection of diseases that cause inflammation within the glomerulus and other renal compartments with significant morbidity and mortality. In general, CD4 T cells orchestrate the immune response and play a unique role in autoimmune and chronic inflammatory diseases. In particular, the characterization of a distinct, IL-17 cytokines producing CD4 T cell subset named T17 cells has significantly advanced the current understanding of the pathogenic mechanisms of organ-specific immunity. Read More

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December 2018
2 Reads

Real-world safety experience of tevagrastim/ratiograstim/biograstim and tbo-filgrastim, short-acting recombinant human granulocyte colony-stimulating factors.

Support Care Cancer 2018 Nov 15. Epub 2018 Nov 15.

Teva Pharmaceuticals, Inc., Frazer, PA, USA.

Purpose: Recombinant granulocyte colony-stimulating factors (rG-CSFs), such as filgrastim, are administered to prevent complications in patients receiving chemotherapy. In Europe, a biosimilar to filgrastim, tevagrastim/ratiograstim/biograstim, was approved in 2008. In the USA, the same product was approved as tbo-filgrastim under a 351(a) biologic license application in 2012 with the brand name Granix®. Read More

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November 2018
4 Reads
2.360 Impact Factor

Nerozpoznaná preeklampsie, která se rozvinula do eklamptického záchvatu s fatálním koncem.

Ceska Gynekol Fall 2018;83(4):276-280

Objective: A fatal case of a 37 year old women in the fifth month of pregnancy, who showed no signs of life and who could not be revived is reported.

Design: Case report.

Settings: Forensic expert in healthcare, Liberec; Department of Health Care Disciplines and Population Protection, Faculty of Biomedical engineering, Czech Technical University in Prague; Department of Biology, Faculty of Education, J. Read More

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November 2018
3 Reads

Urine afamin and afamin-creatinine ratio as biomarkers for kidney injury.

Biomark Med 2018 Nov 15. Epub 2018 Nov 15.

Department of Clinical Laboratory, Peking University First Hospital, 100034, Beijing, PR China.

Aim: The aim of this study was to evaluate the urine afamin (uAFM) and afamin-creatinine ratio (AfCR) levels in patients with glomerulonephritis.

Patients & Methods: We determined uAFM and AfCR of 247 healthy volunteers and 129 biopsy-proven glomerulonephritis patients.

Results: Analytical evaluation study revealed the assay is a reliable and robust test for measuring uAFM. Read More

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November 2018
2 Reads