609 results match your criteria Glomerulonephritis Poststreptococcal


Poststreptococcal Illness: Recognition and Management.

Am Fam Physician 2018 Apr;97(8):517-522

University of Tennessee Family Medicine Residency Program, Jackson, TN, USA.

Group A beta-hemolytic streptococcus can cause several postinfectious, nonsuppurative immune- mediated diseases including acute rheumatic fever, poststreptococcal reactive arthritis, pediatric autoimmune neuropsychiatric disorders, and poststreptococcal glomerulonephritis. Except for sporadic outbreaks, poststreptococcal autoimmune syndromes occur most commonly in sub-Saharan Africa, India, Australia, and New Zealand. Children younger than three years are rarely affected by group A streptococcus pharyngitis or rheumatic fever, and usually do not require testing. Read More

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April 2018
2 Reads

Poststreptococcal Glomerulonephritis With Unusual Lung Involvement.

J Clin Rheumatol 2018 Apr 17. Epub 2018 Apr 17.

Department of Rheumatology University Hospital Basel Basel, Switzerland Department of Laboratory Medicine University Hospital Basel, Basel, Switzerland Department of Pathology University Hospital Basel Basel, Switzerland Department of Radiology University Hospital Basel Basel, Switzerland Department of Nephrology and Transplantation Medicine University Hospital Basel Basel, Switzerland Department of Rheumatology University Hospital Basel Basel, Switzerland.

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April 2018
1 Read

Anticardiolipin antibodies in concurrent poststreptococcal glomerulonephritis and autoimmune hemolytic anemia: A case report.

Arch Argent Pediatr 2018 Apr;116(2):e288-e291

Department of Pedi-Nephrology, Xinhua Hospital affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China.

We present a case of acute post-streptococcal glomerulonephritis (APSGN) with autoimmune hemolytic anemia (AIHA). Along with the classic findings of APSGN, the patient had a positive direct antiglobulin test and an anticardiolipin antibody without any typical clinical manifestations of antiphospholipid syndrome (APS). This case raises questions of the relationship between Streptococcus and the development of autoimmune hemolytic anemia in children. Read More

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April 2018
4 Reads

A Pediatric Case of Diffuse Alveolar Hemorrhage Secondary to Poststreptococcal Glomerulonephritis.

Case Rep Crit Care 2017 20;2017:1050284. Epub 2017 Dec 20.

Division of Pediatric Respirology, University of Saskatchewan, Saskatoon, SK, Canada.

This report summarizes a case of a 4-year-old girl with poststreptococcal glomerulonephritis and diffuse alveolar hemorrhage, an atypical presentation in this age group and type of vasculitic disease. We propose that her rapid improvement in clinical status was due to her treatment, continuous renal replacement therapy (CRRT). This mechanism would have impacted recovery by removing factors such as endothelial microparticles, superantigens, and immune complexes that have been postulated as the pulmonary-renal link. Read More

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December 2017
3 Reads

Effect of the 2015 earthquake on pediatric inpatient pattern at a tertiary care hospital in Nepal.

BMC Pediatr 2018 02 5;18(1):28. Epub 2018 Feb 5.

American International Medical University, Gros Islet, Saint Lucia.

Background: Earthquakes impact child health in many ways. Diseases occurring immediately following an earthquake have been studied in field based hospitals but studies on the inpatient disease pattern among children without trauma in a permanent hospital setup is lacking.

Methods: We examined the diagnoses of all children without trauma, admitted to Kanti Children's Hospital, Kathmandu for fifteen-week duration (from 4th week to end of the 18th week) following the 7. Read More

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February 2018
5 Reads

Posterior reversible encephalopathy syndrome secondary to asymptomatic poststreptococcal glomerulonephritis in a child with sickle cell anemia: a case report.

J Med Case Rep 2018 Feb 1;12(1):24. Epub 2018 Feb 1.

Prince Sultan Oncology Center, King Salman Armed Forces Hospital, Tabuk, 100, Kingdom of Saudi Arabia.

Background: Posterior reversible encephalopathy syndrome is a neurotoxic condition that occurs as a result of the failure of posterior circulatory autoregulation in response to acute changes in blood pressure. Overperfusion with resultant disruption of the blood-brain barrier results in vasogenic edema, but not infarction. Posterior reversible encephalopathy syndrome can be the presenting feature of postinfectious glomerulonephritis, which has been reported in approximately 5% of hospitalized children, and it has been reported in very few cases of adult patients with sickle cell anemia. Read More

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February 2018
4 Reads

Posterior Reversible Encephalopathy Syndrome Secondary to Acute PostStreptococcal Glomerulonephritis in a 12-year-old Girl.

J Coll Physicians Surg Pak 2018 Jan;28(1):80-81

Department of Pediatric Medicine Unit-1, Nishtar Hospital, Multan.

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January 2018
5 Reads

Infection-related glomerulonephritis in a renal allograft.

Saudi J Kidney Dis Transpl 2017 Nov-Dec;28(6):1421-1426

Department of Nephrology, Madras Medical College and Rajiv Gandhi Government General Hospital, Chennai, Tamil Nadu, India.

Infection-related glomerulonephritis (IRGN) is an immune-mediated glomerulo-nephritis, most commonly caused by bacterial infections. Although there is an increased incidence of infectious episodes in renal transplant recipients, IRGN as a cause of de novo glomerulonephritis is rarely seen probably due to impaired immunity. We hereby report a 28-year-old male renal transplant recipient, who developed IRGN following impetigenous skin lesions after six years of transplant. Read More

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December 2017
6 Reads

Clinical characteristics of hypertensive encephalopathy in pediatric patients.

Korean J Pediatr 2017 Aug 14;60(8):266-271. Epub 2017 Aug 14.

Department of Pediatrics, Chonbuk National University Medical School, Jeonju, Korea.

Purpose: The aim of this study was to assess the clinical characteristics of hypertensive encephalopathy according to the underlying etiologies in children.

Methods: We retrospectively evaluated 33 pediatric patients who were diagnosed as having hypertensive encephalopathy in Chonbuk National University Children's Hospital. Among the patients, 18 were excluded because of incomplete data or because brain magnetic resonance imaging (MRI) was not performed. Read More

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August 2017
2 Reads

Group A streptococcal pharyngitis: Immune responses involved in bacterial clearance and GAS-associated immunopathologies.

J Leukoc Biol 2018 Feb 29;103(2):193-213. Epub 2017 Dec 29.

School of Chemistry and Molecular Biosciences, Australian Infectious Diseases Research Centre, The University of Queensland, Brisbane, Australia.

Streptococcus pyogenes, the Group A Streptococcus (GAS), is the most common cause of bacterial pharyngitis in children and adults. Innate and adaptive host immune responses are fundamental for defense against streptococcal pharyngitis and are central to the clinical manifestation of disease. Host immune responses also contribute to the severe poststreptococcal immune diseases that constitute the major disease burden for this organism. Read More

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February 2018
8 Reads

Concurrent Acute Glomerulonephritis and Retropharyngeal Abscess in 10 Year Boy: A Case Report.

J Clin Diagn Res 2017 Jul 1;11(7):SD13-SD14. Epub 2017 Jul 1.

Professor, Department of Radiodiagnosis, Pt B D Sharma PGIMS, Rohtak, Haryana, India.

Postinfectious Glomerulonephritis (PIGN) usually follows 1-2 weeks after respiratory tract infection and 4-6 weeks after skin infection. Acute Glomerulonephritis (AGN) is uncommon with simultaneous severe throat infections. We describe a 10-year-old boy who was presented with high grade fever, dysphagia and tender swelling over left side of neck. Read More

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July 2017
6 Reads

Cardiac status in children with acute poststreptococcal glomerulonephritis.

Saudi J Kidney Dis Transpl 2017 Jul-Aug;28(4):830-835

Department of Pediatrics, Division of Pediatric Nephrology, Lokmanya Tilak Municipal Medical College and General Hospital, Mumbai, Maharashtra, India.

Acute poststreptococcal glomerulonephritis (PSGN) is the most common type of glomerulonephritis seen in children. It can affect multiple organs with heart being frequently involved. Yet, there are very few studies on cardiac status in children with PSGN and hence this study was conducted. Read More

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July 2017
4 Reads

A rare adult case of poststreptococcal acute glomerulonephritis with a retropharyngeal abscess.

CEN Case Rep 2017 May 27;6(1):118-123. Epub 2017 Mar 27.

Division of Nephrology, Department of Internal Medicine, Saga University Faculty of Medicine, 5-1-1 Nabeshima, Saga, Saga, 849-8501, Japan.

Retropharyngeal abscess is an infection involving the retropharyngeal space which is posterior to the pharynx and oesophagus, and it results as a complication of a primary infection elsewhere in the head and neck including the nasopharynx, paranasal sinuses, or middle ear, which drain lymph to the retropharyngeal lymph nodes. Their lymph nodes are prominent in children and atrophy with age. Therefore, retropharyngeal abscess is most frequently encountered in children, with 75% of cases occurring before the age of 5 years, and often in the first year of life. Read More

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May 2017
7 Reads

Posterior reversible encephalopathy in an adult patient with poststreptococcal glomerulonephritis.

BMJ Case Rep 2017 Apr 17;2017. Epub 2017 Apr 17.

Department of Medicine, Metropolitan Hospital Center, New York, New York, USA.

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April 2017
1 Read

Multiple Causes of Hyponatremia: A Case Report.

Med Princ Pract 2017 7;26(3):292-295. Epub 2017 Mar 7.

Clinic of Endocrinology, Diabetes and Metabolic Diseases, Clinical Center of Vojvodina, Novi Sad, Serbia.

Objective: To present a case with 4 different potential causes of hyponatremia.

Clinical Presentation And Intervention: The patient presented with the following symptoms: nausea, vomiting, diarrhea, and dark urine after drinking large amounts of fluids that included alcohol and caffeine. Laboratory, microbiological, and morphological examinations revealed the existence of severe hyponatremia and acute poststreptococcal glomerulonephritis. Read More

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March 2018
5 Reads

Posterior reversible encephalopathy syndrome in children: a case series.

Turk Pediatri Ars 2016 Dec 1;51(4):217-220. Epub 2016 Dec 1.

Division of Pediatric Hematology, Necmettin Erbakan University Meram School of Medicine, Konya, Turkey.

Posterior reversible encephalopathy syndrome is characterized by hypertension, seizure, headache, clouding of consciousness, and visual disturbance, and is diagnosed in the presence of typical lesions on magnetic resonance imaging. We retrospectively evaluated five patients who were diagnosed as having posterior reversible encephalopathy syndrome and followed up in Meram Medical Faculty, Pediatric Intensive Care and Hematology wards, between January 2010 and January 2014. We reviewed the demographic and clinical data, and neuroimaging findings. Read More

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December 2016
7 Reads

A Case of Thyroid Storm Associated with Cardiomyopathy and Poststreptococcal Glomerulonephritis.

Case Rep Pediatr 2016 27;2016:7192359. Epub 2016 Oct 27.

Department of Pediatric Endocrinology and Diabetes and Department of Pediatric Nephrology, The Children's Hospital at Montefiore, 3415 Bainbridge Ave., Bronx, NY 10467, USA.

Thyroid storm has a high mortality rate and is often associated with a precipitating factor such as intercurrent illness or infection. It is rare in pediatric patients. Cardiac disease in hyperthyroidism mostly manifests itself as tachycardia but more serious cardiac findings have also been described. Read More

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October 2016
4 Reads

Acute Cardiac Tamponade in a 58-Year-Old Male with Poststreptococcal Glomerulonephritis.

Methodist Debakey Cardiovasc J 2016 Sep;12(3):175-176

Virginia Commonwealth University Health System, Richmond, Virginia; Hunter Holmes McGuire VA Medical Center, Richmond, Virginia.

Pericarditis in conjunction with nephritis is an uncommon clinical scenario with a broad differential diagnosis. We present the case of a 58-year-old male who developed nephritis and pericardial effusion with tamponade physiology. In the following, we discuss the differential diagnosis for concomitant nephritis and pericarditis and discuss the work-up performed on our patient. Read More

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September 2016
4 Reads

Staphylococcus Infection-Associated GN - Spectrum of IgA Staining and Prevalence of ANCA in a Single-Center Cohort.

Clin J Am Soc Nephrol 2017 Jan 7;12(1):39-49. Epub 2016 Nov 7.

Department of Pathology, and.

Background And Objectives: Staphylococcus infection-associated GN (SAGN) is a well recognized disease entity, particularly because of the frequent IgA-dominant glomerular immunoglobulin staining on kidney biopsy. Biopsy features can resemble two other disease entities - primary IgA nephropathy and Henoch-Schönlein purpura nephritis - posing a diagnostic pitfall. This is clinically relevant because of the crucial difference in the therapeutic approach. Read More

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January 2017
10 Reads

Serum myeloid-related protein 8/14 in minimal change- and glomerulonephritis-related nephrotic syndrome.

Pediatr Int 2016 Oct 26;58(10):998-1002. Epub 2016 Apr 26.

Department of Pediatrics, Fukushima Medical University School of Medicine, Fukushima City, Fukushima, Japan.

Background: Myeloid-related protein 8/14 (MRP8/14) forms stable heterodimers and is the major calcium-binding protein secreted by activated granulocytes and monocytes. We evaluated whether serum MRP8/14 level is a useful indicator for a differential diagnosis of glomerulonephritis (GN)- and minimal change disease (MC)- related nephrotic syndrome (NS).

Methods: Serum MRP8/14 complex was evaluated in 37 NS patients with MC or GN. Read More

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October 2016
9 Reads

Acute Kidney Injury and Atypical Features during Pediatric Poststreptococcal Glomerulonephritis.

Int J Nephrol 2016 23;2016:5163065. Epub 2016 Aug 23.

Division of Nephrology, Department of Pediatrics, Nationwide Children's Hospital, Columbus, OH, USA.

The most common acute glomerulonephritis in children is poststreptococcal glomerulonephritis (PSGN) usually occurring between 3 and 12 years old. Hypertension and gross hematuria are common presenting symptoms. Most PSGN patients do not experience complications, but rapidly progressive glomerulonephritis and hypertensive encephalopathy have been reported. Read More

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September 2016
6 Reads

Acute poststreptococcal glomerulonephritis and acute rheumatic fever: An uncommon coincidence.

Ann Pediatr Cardiol 2016 Sep-Dec;9(3):268-9

Center of Pediatrics, Children's Hospital, Affiliate of Vilnius University Hospital Santariskiu Klinikos, Vilnius, Lithuania; Clinic of Pediatrics, Faculty of Medicine, Vilnius University, Vilnius, Lithuania E-mail:

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September 2016
2 Reads

Post-streptococcal glomerulonephritis associated with atypical hemolytic uremic syndrome: to treat or not to treat with eculizumab?

Clin Kidney J 2016 Feb 26;9(1):90-6. Epub 2015 Nov 26.

Division of Nephrology, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.

A 7-year-old male with poststreptococcal glomerulonephritis (PSGN) developed hemolytic uremic syndrome (HUS) and achieved remission. He was treated with eculizumab for 1 year. The eculizumab was discontinued and the patient remained in remission. Read More

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February 2016
2 Reads

IgA-dominant acute poststreptococcal glomerulonephritis with concomitant rheumatic fever successfully treated with steroids: a case report.

Croat Med J 2015 Dec;56(6):567-72

Rina R. Rus, Division of Nephrology, University Children's Hospital, Bohoričeva 20, 1000 Ljubljana, Slovenia,

There are only a few reports of the co-occurrence of acute poststreptococcal glomerulonephritis (APGN) and acute rheumatic fever. We report an unusual case of a 3-year-old boy with nephrotic syndrome and acute renal failure with the transitional need for peritoneal dialysis, biopsy-proven atypical IgA-dominant APGN, and concomitant acute rheumatic fever, successfully treated by steroids. Aggressive treatment with pulses of methylprednisolone proved to be successful and we recommend its use in this type of cases. Read More

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December 2015
2 Reads

Poststreptococcal acute glomerulonephritis presenting as posterior reversible encephalopathy syndrome in an eleven-year-old boy.

Minerva Pediatr 2015 Dec;67(6):531-3

Department of Pediatrics, S. Chiara University Hospital, Pisa, Italy -

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December 2015
1 Read

Lupus Anticoagulant Positivity in Pediatric Patients With Prolonged Activated Partial Thromboplastin Time: A Single-Center Experience and Review of Literature.

Pediatr Hematol Oncol 2015 18;32(7):495-504. Epub 2015 Sep 18.

b Department of Biochemistry , Dr. Sami Ulus Research and Training Hospital of Women's and Children's Health and Diseases , Ankara , Turkey.

The presence of lupus anticoagulants (LAs) is an important cause of activated partial thromboplastin time (aPTT) prolongation found in children after an infection or during screening tests before surgical intervention. The authors retrospectively reviewed the charts of 68 patients who have been consulted from surgery departments with prolonged aPTT. These patients were reevaluated with aPTT analysis after 1 week. Read More

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September 2016
2 Reads

Poststreptococcal glomerulonephritis in children with congenital anomalies of the kidney and urinary tract.

Ren Fail 2015 3;37(9):1440-3. Epub 2015 Sep 3.

b Department of General and Transplant Surgery , University Hospital Heidelberg , Heidelberg , Germany.

Background: The objective of this study was to assess clinical course and outcome of children with congenital anomalies of the kidney and urinary tract (CAKUT) who had an attack of acute poststreptococcal glomerulonephritis (PSGN).

Method: Renal status including blood pressure, proteinuria and glomerular filtration rate was retrospectively analyzed in five children with CAKUT and PSGN at the presentation and during the follow up.

Results: In the period 2004-2013, 678 patients were diagnosed and recruited in our CAKUT cohort. Read More

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August 2016
5 Reads

Delayed Development of Primary Biliary Cirrhosis in a Patient with Acute Glomerulonephritis: A Possible Pitfall of a Self-limiting Disease.

Intern Med 2015 1;54(15):1885-9. Epub 2015 Aug 1.

Division of Nephrology, Department of Medicine, Jichi Medical University, Japan.

Acute poststreptococcal glomerulonephritis (APSGN) is a well-established disease. Although various immune responses are thought to be involved in the pathogenesis of APSGN, the disease has a self-limiting nature in clinical practice, despite the presence of severe acute symptoms. We herein report the case of a 78-year-old woman with APSGN who developed primary biliary cirrhosis (PBC) after achieving remission of renal manifestations, including anasarca and elevation of serum creatinine, indicating that persistent alterations in the immune system can cause extrarenal disorders. Read More

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March 2016
3 Reads

Seropositivity for Antibodies to DRS-G, a Virulence Factor from Streptococcus dysgalactiae subsp. equisimilis, Is an Independent Risk Factor for Poststreptococcus Glomerulonephritis and Chronic Kidney Disease in Mumbai, India.

Clin Vaccine Immunol 2015 Aug 17;22(8):938-42. Epub 2015 Jun 17.

QIMR Berghofer, Brisbane, Australia

The disease spectrum caused by Streptococcus dysgalactiae subsp. equisimilis resembles that of S. pyogenes (group A streptococcus [GAS]). Read More

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August 2015
6 Reads

A 12-year-old boy with dyspnea, hypertension, hematuria, and proteinuria.

Hosp Pediatr 2015 Jun;5(6):348-51

Departments of Pediatrics, and Internal Medicine, Los Angeles County + University of Southern California Medical Center, Keck School of Medicine, Los Angeles, California

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June 2015
1 Read

Crescentic acute glomerulonephritis with isolated C3 deposition: a case report and review of literature.

Int J Clin Exp Pathol 2015 1;8(2):1826-9. Epub 2015 Feb 1.

Department of Nephrology, Nanjing Children's Hospital, Affiliated to Nanjing Medical University Nanjing, China.

An eight-year-old girl, presenting with palpebral edema, gross hematuria, and foam in urine, was admitted to our hospital. Investigations indicated increased serum antistreptolysin O (ASO) and anti-mycoplasma antibody titers. Renal biopsy showed crescentic poststreptococcal acute glomerulonephritis (CPAGN) with isolated C3 deposition in the glomeruli. Read More

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February 2016
7 Reads
1.78 Impact Factor

Staphylococcus-related glomerulonephritis and poststreptococcal glomerulonephritis: why defining "post" is important in understanding and treating infection-related glomerulonephritis.

Am J Kidney Dis 2015 Jun 15;65(6):826-32. Epub 2015 Apr 15.

Ohio State University Wexner Medical Center, Columbus, OH. Electronic address:

A spate of recent publications describes a newly recognized form of glomerulonephritis associated with active staphylococcal infection. The key kidney biopsy findings, glomerular immunoglobulin A (IgA) deposits dominant or codominant with IgG deposits, resemble those of IgA nephritis. Many authors describe this condition as "postinfectious" and have termed it "poststaphylococcal glomerulonephritis. Read More

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June 2015
7 Reads

Concurrent peritonsillar abscess and poststreptococcal reactive arthritis complicating acute streptococcal tonsillitis in a young healthy adult: a case report.

BMC Infect Dis 2015 Feb 7;15:50. Epub 2015 Feb 7.

Medical Microbiology Department, Medical University of Lublin, ul. Chodźki 1, 20-093, Lublin, Poland.

Background: Streptococcus pyogenes is responsible for 5-15% and 20-30% of acute pharyngitis/tonsillitis in adults and children, respectively. It not only causes acute illness but also can give rise to local suppurative complications such as peritonsillar abscess as well as trigger the postinfectious syndromes of glomerulonephritis, acute rheumatic fever and poststreptococcal reactive arthritis. Here, we report a case of a young healthy adult in whom both peritonsillar abscess and poststreptococcal reactive arthritis developed as a complication of acute streptococcal tonsillitis. Read More

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February 2015
4 Reads

Diffuse alveolar hemorrhage in a patient with acute poststreptococcal glomerulonephritis caused by impetigo.

Intern Med 2015 15;54(8):961-4. Epub 2015 Apr 15.

Department of Internal Medicine, Division of Respiratory Medicine, Jikei University School of Medicine, Kashiwa Hospital, Japan.

We herein report a case of pulmonary renal syndrome with nephritis in a 17-year-old boy with diffuse alveolar hemorrhage (DAH) associated with acute poststreptococcal glomerulonephritis (APSGN). The patient exhibited hemoptysis two weeks after developing impetigo, and DAH was diagnosed on bronchoscopy. Respiratory failure progressed, and high-dose methylprednisolone therapy was administered; the respiratory failure regressed immediately after the onset of therapy. Read More

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September 2015
2 Reads

Poststreptococcal glomerulonephritis in a patient with essential thrombocytosis.

J Nippon Med Sch 2015 ;82(1):59-63

Department of Nephrology, School of Medicine, Karadeniz Technical University.

In addition to being the main cause of glomerulonephritis in children, poststreptococcal glomerulonephritis (PSGN) has recently been shown in older patients, especially those with malignancy or diabetes mellitus. The pathogenesis of PSGN has been ascribed to activation of complement 3 (C3) of the alternative complement cascade which, along with immunoglobulin (Ig) G and IgM deposits, is observed in renal tissue. Our aim here is to discuss the probable causes of PSGN developing with isolated IgM deposition in a 52-year-old patient with essential thrombocytosis followed-up over the previous 3. Read More

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March 2016
2 Reads

[In Process Citation].

Authors:
Andreas Fischer

Ther Umsch 2015 Mar;72(3):141-7

Abteilung für Nephrologie, Departement Medizin, Kantonsspital, Luzern.

Postinfectious glomerulonephritis is an immune-mediated disease occurring as a result of the host response to an extrarenal infection. The classical form of poststreptococcal disease is decreasing worldwide but remains a significant health care problem in developing countries, especially in children. In industrialised countries postinfectious glomerulonephritis is now primarily due to non-streptococcal disease. Read More

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March 2015
2 Reads

Acute poststreptococcal glomerulonephritis: the most common acute glomerulonephritis.

Pediatr Rev 2015 Jan;36(1):3-12; quiz 13

Division of Pediatric Nephrology and Hypertension, Cincinnati Children's Hospital Medical Center, Cincinnati, OH.

On the basis of strong research evidence, the prevalence of poststreptococcal glomerulonephritis (PSGN) is decreasing worldwide, although it still remains the leading cause of glomerulonephritis in children. The overall decrease in prevalence of PSGN has been mainly driven by a significant decrease in pyoderma seen in the last half-century, such that postpharyngitic PSGN is most commonly seen in developed nations. On the basis of primarily consensus because of a lack of relevant clinical studies, the latency period between streptococcal infection and the development of nephritis is a hallmark of PSGN, with this period lasting 1 to 2 weeks with pharyngeal infections or 2 to 6 weeks with skin infections. Read More

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January 2015
5 Reads

Impetigo: diagnosis and treatment.

Am Fam Physician 2014 Aug;90(4):229-35

West Virginia University Robert C. Byrd Health Sciences Center, Morgantown, WV, USA.

Impetigo is the most common bacterial skin infection in children two to five years of age. There are two principal types: nonbullous (70% of cases) and bullous (30% of cases). Nonbullous impetigo, or impetigo contagiosa, is caused by Staphylococcus aureus or Streptococcus pyogenes, and is characterized by honey-colored crusts on the face and extremities. Read More

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August 2014
3 Reads

The influence of birthweight, past poststreptococcal glomerulonephritis and current body mass index on levels of albuminuria in young adults: the multideterminant model of renal disease in a remote Australian Aboriginal population with high rates of renal disease and renal failure.

Nephrol Dial Transplant 2016 06 24;31(6):971-7. Epub 2014 Jul 24.

Royal Children's Hospital, University of Melbourne, Melbourne, Victoria, Australia.

Background: Australian Aborigines in remote areas have very high rates of kidney disease, which is marked by albuminuria. We describe a 'multihit' model of albuminuria in young adults in one remote Aboriginal community.

Methods: Urinary albumin/creatinine ratios (ACRs) were measured in 655 subjects aged 15-39 years and evaluated in the context of birthweights, a history of 'remote' poststreptococcal glomerulonephritis (PSGN; ≥5 years earlier) and current body mass index (BMI). Read More

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June 2016
8 Reads

Diffuse alveolar hemorrhage as a presentation of acute poststreptococcal glomerulonephritis.

Am J Med 2014 Sep 10;127(9):e15-7. Epub 2014 Jun 10.

Division of Nephrology, Hypertension and Renal Transplantation, University of Florida, Gainesville.

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September 2014
3 Reads

Unusual presentation of poststreptococcal glomerulonephritis as posterior reversible encephalopathy syndrome.

J Pediatr Neurosci 2014 Jan;9(1):42-4

Department of Pediatrics, Lokmanya Tilak Municipal Medical College and General Hospital, Sion, Mumbai, Maharashtra, India.

Posterior reversible encephalopathy syndrome (PRES) is a rare clinicoradiologic condition manifesting with headache, seizures, altered sensorium, visual disturbances, and characteristic lesions on neuroimaging predominantly affecting the posterior regions of the brain. We report a case of an 8-year-old boy with poststreptococcal glomerulonephritis, presenting as PRES. A magnetic resonance imaging showed hyperintense lesions in bilateral frontal and parietooccipital parenchyma on fluid-attenuated inversion recovery and T2-weighted images, suggestive of "PRES. Read More

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January 2014
2 Reads

Disease manifestations and pathogenic mechanisms of Group A Streptococcus.

Clin Microbiol Rev 2014 Apr;27(2):264-301

School of Chemistry and Molecular Biosciences and the Australian Infectious Diseases Research Centre, University of Queensland, Brisbane, QLD, Australia.

Streptococcus pyogenes, also known as group A Streptococcus (GAS), causes mild human infections such as pharyngitis and impetigo and serious infections such as necrotizing fasciitis and streptococcal toxic shock syndrome. Furthermore, repeated GAS infections may trigger autoimmune diseases, including acute poststreptococcal glomerulonephritis, acute rheumatic fever, and rheumatic heart disease. Combined, these diseases account for over half a million deaths per year globally. Read More

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April 2014
1 Read

How to use antistreptolysin O titre.

Authors:
E S Sen A V Ramanan

Arch Dis Child Educ Pract Ed 2014 Dec 30;99(6):231-8. Epub 2014 Jan 30.

Department of Paediatric Rheumatology, Bristol Royal Hospital for Children, Bristol, UK.

Group A streptococcus (GAS) is the cause of a wide range of acute suppurative and, following a latent period, non-suppurative diseases such as rheumatic fever and poststreptococcal glomerulonephritis. Diagnosis of the latter group requires evidence of preceding GAS infection. The bacteria produce a range of extracellular antigens, including streptolysin O, which induce an antibody response in the host. Read More

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December 2014
2 Reads

Posterior reversible encephalopathy syndrome in children: report of three cases.

Childs Nerv Syst 2014 Mar 20;30(3):535-40. Epub 2013 Dec 20.

Department of Pediatrics, Konya Training and Research Hospital, Meram, 42090, Konya, Turkey,

Purpose: Posterior reversible encephalopathy syndrome (PRES) is a condition characterized by varying degrees of headache, nausea, vomiting, visual disturbances, focal neurologic deficit, and seizures due to severe systemic hypertension. The knowledge of secondary hypertension in children is most commonly due to renal abnormalities, suggesting that the leading cause of PRES in childhood is renal diseases.

Methods: Three pediatric patients who developed PRES due to various underlying renal diseases were reviewed. Read More

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March 2014
2 Reads

Podocyte injury in segmental garland-pattern poststreptococcal glomerulonephritis.

Iran J Kidney Dis 2013 Sep;7(5):356

Department of Pathology, Faculty of Medicine of Ribeirão Preto, University of São Paulo, São Paulo, Brazil.

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September 2013
3 Reads

[A case of crescentic poststreptococcal acute glomerulonephritis (PSAGN) accompanied by membranous nephropathy].

Nihon Jinzo Gakkai Shi 2013 ;55(4):567-73

Department of Geriatric Medicine and Nephrology, Osaka University Graduate School of Medicine, Osaka, Tokyo.

In 2010, a 71-year-old man was referred to our hospital because of mild proteinuria and hematuria. At that time, he had been asymptomatic. Three months later he noticed macroscopic hematuria, followed by general malaise, and then anorexia. Read More

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September 2013
1 Read

Immune complex binding Streptococcus pyogenes type M12/emm12 in experimental glomerulonephritis.

J Med Microbiol 2013 Sep 20;62(Pt 9):1272-80. Epub 2013 Jun 20.

Institute of Experimental Medicine RAMS, St-Petersburg, Russia.

In a rabbit model, we have previously reported evidence for a pathogenic role of streptococcal IgG Fc-binding proteins (IgGFcBP) in poststreptococcal glomerulonephritis (PSGN). These proteins, of the M protein family, were shown to trigger anti-IgG production and enhance renal deposition of IgG and/or immune complexes (ICs), with resulting activation of complement and cytokine cascades. In the present study, type M12/emm12, group A streptococci (GAS) were found often to bind artificial ICs, viz. Read More

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September 2013
2 Reads

Prospective population-based study on the burden of disease from post-streptococcal glomerulonephritis of hospitalised children in New Zealand: epidemiology, clinical features and complications.

J Paediatr Child Health 2013 Oct 18;49(10):850-5. Epub 2013 Jun 18.

Department of Paediatric Nephrology, Starship Children's Hospital, Auckland, New Zealand.

Aim: A nationwide 24-month study was conducted (2007-2009), via the New Zealand Paediatric Surveillance Unit to define epidemiology and clinical features of acute poststreptococcal glomerulonephritis (APSGN) in children hospitalised with the illness.

Methods: Paediatricians (n = 215) were requested to report new hospitalised cases fulfilling a case definition of definite (haematuria with low C3 and high streptococcal titres or biopsy proven APSGN) or probable (haematuria with low C3 or high streptococcal titres).

Results: A total of 176 cases were identified (definite: n = 138, probable: n = 38) with 63% residing in the Auckland metropolitan region. Read More

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October 2013
2 Reads