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Int Urol Nephrol 2021 May 15. Epub 2021 May 15.

Nephrology Clinic, Dialysis and Renal Transplant Center, 'C.I. Parhon' University Hospital, and "Grigore T. Popa" University of Medicine, Iasi, Romania.

Purpose: The aim of this retrospective study was: to analyze the epidemiological patterns of the kidney disease based on clinical and histological features in a single-center in the N-E region of Romania, between 2011 and 2019 and to compare the biopsy results with the others periods, as well as the results from other countries.

Methods: We studied 442 renal biopsies. The indications for renal biopsy were represented by the clinical features: nephrotic syndrome, nephritic syndrome, asymptomatic urinary abnormalities, acute kidney injury, and chronic kidney disease of unknown etiology. Read More

Turk J Med Sci 2021 May 14. Epub 2021 May 14.

Background And Aim: Compared to healthy controls, mean platelet volume (MPV) is frequently higher in patients with Familial Mediterranean fever (FMF) but lower in AA amyloidosis patients. The reason for the difference in MPV levels in FMF patients with and without AA amyloidosis is unclear. The aim of the study was to determine whether low MPV is unique to AA amyloidosis or MPV is similarly low in all glomerular diseases as a result of proteinuria and/or renal dysfunction. Read More

Ren Fail 2021 Dec;43(1):851-859

The Department of Nephropathy, The Second Hospital of Jilin University, Changchun, China.

Purpose: To identify the clinical characteristics, histopathological features, and prognosis of kidney disease in a large cohort of elderly patients from Northeast China.

Methods: We retrospectively analyzed the renal disease spectrum in 7,122 patients who underwent renal biopsies at the Second Hospital of Jilin University from 2006 to 2020. Patients were grouped according to age: below 60 years (non-elderly group,  = 5923) and at least 60 years (elderly group,  = 1199). Read More

Indian Dermatol Online J 2021 Mar-Apr;12(2):349-350. Epub 2021 Mar 2.

Department of Dermatology, Venereology and Leprology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.

J Cell Mol Med 2021 May 3. Epub 2021 May 3.

Kidney Research Institute, Seoul National University, Seoul, Korea.

Identification of a urinary metabolite biomarker with diagnostic or prognostic significance for early immunoglobulin A nephropathy (IgAN) is needed. We performed nuclear magnetic resonance-based metabolomic profiling and identified 26 metabolites in urine samples. We collected urine samples from 201, 77, 47, 36 and 136 patients with IgAN, patients with membranous nephropathy, patients with minimal change disease, patients with lupus nephritis and healthy controls, respectively. Read More

J Clin Med 2021 Apr 24;10(9). Epub 2021 Apr 24.

Department of Medicine, Division of Nephrology, Columbia University Irving Medical Center, New York, NY 10032, USA.

The prevalence of diabetes continues to rise worldwide. In addition to rising rates of diabetic kidney disease, we are also seeing a parallel rise in nondiabetic kidney disease among patients with diabetes. These nondiabetic lesions include focal segmental glomerulosclerosis, IgA nephropathy, membranous nephropathy, and other glomerular diseases. Read More

Zhonghua Bing Li Xue Za Zhi 2021 May;50(5):532-534

Department of Nephrology,Changzhi People's Hospital,Shanxi Province, Changzhi 046000,China.

Kidney Int Rep 2021 Apr 13;6(4):881-893. Epub 2021 Jan 13.

Division of Nephrology, Department of Medicine IV, University Hospital, LMU Munich, Munich, Germany.

Membranous nephropathy (MN) is the most common cause of primary nephrotic syndrome among adults. The identification of phospholipase A2 receptor (PLA2R) as target antigen in most patients changed the management of MN dramatically, and provided a rationale for B-cell depleting agents such as rituximab. The efficacy of rituximab in inducing remission has been investigated in several studies, including 3 randomized controlled trials, in which complete and partial remission of proteinuria was achieved in approximately two-thirds of treated patients. Read More

Zhonghua Yi Xue Za Zhi 2021 Apr;101(16):1149-1153

Department of Nephrology, the First Affiliated Hospital of Zhengzhou University/Research Institute of Nephrology of Zhengzhou University/Research Center for Kidney Disease, Henan Province/Key Laboratory of Precision Diagnosis and Treatment for Chronic Kidney Disease in Henan Province/Core Unit of National Clinical Medical Research Center of Kidney Disease, Zhengzhou 450052, China.

To explore the relationship between polycyclic aromatic hydrocarbons (PAHs), the major component of atmospheric pollutant particulate matter 2.5 (PM) and idiopathic membranous nephropathy (IMN) and its possible mechanisms. Thirty-five (24 males and 11 females) patients with IMN confirmed by renal biopsy pathology in the First Affiliated Hospital of Zhengzhou University from June to September 2020 were selected as the research group, with an age of (47. Read More

Ultrastruct Pathol 2021 Apr 25:1-12. Epub 2021 Apr 25.

Glasgow Renal & Transplant Unit, Queen Elizabeth University Hospital, Glasgow, UK.

There are limited data concerning the range and diagnostic significance of the extent of subepithelial electron dense deposits (SEEDD) in membranous glomerulonephritis (MGN). We described the range, and assessed the diagnostic and prognostic significance of extent of SEEDD, particularly in patients with sparse SEEDD, where diagnostic difficulty can arise. Adult renal biopsies with a confident or suspected histological diagnosis of MGN between 2013 and 2020 were included. Read More

BMC Nephrol 2021 Apr 21;22(1):143. Epub 2021 Apr 21.

Renal Division, Department of Medicine, West China Hospital of Sichuan University, 610041, Chengdu, China.

Background: C3 glomerulopathy (C3G) is a recent disease classification that is characterized by the presence of glomerular deposits (composed of C3) in the absence of significant amounts of immunoglobulin and comprises dense deposit disease and C3 glomerulonephritis (C3GN). Most C3GN manifests as membranoproliferative, mesangial proliferative glomerulonephritis patterns via light microscopy. Pure membranous nephropathy (MN)-like glomerular lesions are rare manifestations of C3GN. Read More

Pediatr Nephrol 2021 Apr 20. Epub 2021 Apr 20.

Pediatric Nephrology Department, Charles Nicolle Hospital, Tunis, Tunisia.

Pediatr Nephrol 2021 Apr 20. Epub 2021 Apr 20.

Pediatric Nephrology Department, Charles Nicolle Hospital, Tunis, Tunisia.

World J Clin Cases 2021 Apr;9(10):2357-2366

Department of Nephrology, Shenzhen Longhua District Central Hospital, Shenzhen 518110, Guangdong Province, China.

Background: Proliferative glomerulonephritis with monoclonal immunoglobulin G (IgG) deposits (PGNMID) is a newly recognized rare disease. The renal pathology is characterized by prominent manifestations of membranous hyperplasia, which are easy to misdiagnose. The clinical symptoms are severe. Read More

BMC Nephrol 2021 Apr 14;22(1):130. Epub 2021 Apr 14.

Department of Nephrology, Guangzhou Women and Children's Medical Center, Guangzhou city, 510623, China.

Background: This study aimed to investigate the expression characteristics of ANGPTL8 in patients with primary nephrotic syndrome and its possible correlation with hyperlipidemia and proteinuria.

Methods: ANGPTL8 levels were determined using an enzyme-linked immunosorbent assay in 133 subjects with PNS and 60 healthy controls.

Results: Compared with healthy controls, subjects with primary nephrotic syndrome had higher levels of serum and urine ANGPTL8 (P < 0. Read More

Indian J Pathol Microbiol 2021 Apr-Jun;64(2):282-287

Department of Anatomy, IPGMER and SSKM Hospital, Kolkata, West Bengal, India.

Background: Proliferative glomerulonephritis with monoclonal immunoglobulin deposit (PGNMID) is an entity with a variable clinical and histological spectrum, which mimics immune-complex mediated glomerulonephritis on light microscopy. In this article, we aim to describe the clinical and pathological features of six cases of PGNMID that we encountered during our routine practice.

Materials And Methods: The study was of the prospective type carried out from February 2018 to August 2019. Read More

Indian J Nephrol 2020 Nov-Dec;30(6):377-381. Epub 2020 Feb 11.

Department of Histopathology, PGIMER, Chandigarh, India.

Background: Repeat renal biopsy is usually done for lupus nephritis (LN) flare or resistant disease. We analyzed the changes between first and repeat biopsy and the contribution of repeat biopsy on renal outcome in LN patients.

Methods: This was a retrospective study carried out at a tertiary care center in India. Read More

Indian J Nephrol 2020 Nov-Dec;30(6):359-369. Epub 2020 Nov 30.

Division of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota, USA.

Renal transplantation is the preferred form of renal replacement therapy in patients who develop end-stage kidney disease (ESKD). Among the diverse etiologies of ESKD, glomerulonephritis is the third most common cause, behind hypertensive and diabetic kidney disease. Although efforts to prolong graft survival have improved over time with the advent of novel immunosuppression, recurrent glomerulonephritis remains a major threat to renal allograft survival despite concomitant immunosuppression. Read More

J Clin Med 2021 Mar 14;10(6). Epub 2021 Mar 14.

Department of Immunology, Transplantology and Internal Diseases, Medical University of Warsaw, 02-006 Warsaw, Poland.

Membranous nephropathy is a glomerulopathy that causes nephrotic syndrome and, in at least a third of cases, lasting end-stage kidney disease (ESKD). It is also a rare case of revolutionary changes in our understanding of the disease, that translates from scientific findings to real diagnosis and treatment recommendations in less than ten years. In this review we present: (1) a short history and traditional approach to patients with membranous nephropathy, (2) current recommendations and treatment options that have emerged in recent years, (3) findings of new studies, with a particular focus on serological/immunological methods, genomic and proteomic studies, still requiring validation. Read More

J Nephrol 2021 04;34(2):273-275

Centre Hospitalier Le Mans, 72000, Le Mans, France.

J Int Med Res 2021 Mar;49(3):300060521999756

Chu Hsien-I Memorial Hospital, Tianjin Institute of Endocrinology, Tianjin Medical University, Tianjin, China.

Secondary renal involvement in chronic exposure to metallic mercury is well known. Mercury also causes central nervous system damage and demyelinating polyneuropathy. Here, we describe a case of a patient with daily exposure to mercury in skin lightening cream and hair dyes who was diagnosed with Guillain-Barre syndrome and then developed nephrotic syndrome because of membranous neuropathy. Read More

BMC Nephrol 2021 Mar 25;22(1):108. Epub 2021 Mar 25.

Department of Rheumatology, Kanazawa University Hospital, Kanazawa University Graduate School of Medical Science, 13-1, Takara-machi, Kanazawa, Ishikawa, 920-8641, Japan.

Background: Primary Sjögren's syndrome (pSS) is an auto-immune disease characterized by sialadenitis and dacryoadenitis with lymphoplasmacytic cell infiltration. In pSS, not only sicca symptoms, but also extra-glandular involvement induced by immune abnormalities based on pSS occurs. Renal involvement is one such important life-threatening extra-glandular involvement. Read More

J Cell Mol Med 2021 May 22;25(10):4684-4695. Epub 2021 Mar 22.

Department of Nephrology, Molecular Cell Laboratory for Kidney Disease, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.

Glomerulonephritis is the one of the major causes of the end-stage kidney disease, whereas the pathological process of glomerulonephritis is still not completely understood. Single-cell RNA sequencing (scRNA-seq) emerges to be a powerful tool to evaluate the full heterogeneity of kidney diseases. To reveal cellular gene expression profiles of glomerulonephritis, we performed scRNA-seq of 2 human kidney transplantation donor samples, 4 human glomerulonephritis samples, 1 human malignant hypertension (MH) sample and 1 human chronic interstitial nephritis (CIN) sample, all tissues were taken from the biopsy. Read More

Kidney Int 2021 04;99(4):811-813

Division of Nephrology, Ohio State University Wexner Medical Center, Columbus, Ohio, USA. Electronic address:

The STARMEN trial postulated that in primary membranous nephropathy (pMN) treatment with tacrolimus plus rituximab would be superior to a traditional Ponticelli regimen of alternating cyclophosphamide and glucocorticoids. This was not the case. Significantly more remissions were achieved in cyclophosphamide-treated patients, and more of these were complete remissions. Read More

Kidney Int 2021 04;99(4):1024-1025

Instituto de Investigación Hospital Universitario 12 de Octubre, Madrid, Spain; Department of Medicine, Complutense University, Madrid, Spain. Electronic address:

Kidney Int 2021 04;99(4):1023-1024

Département Néphrologie et Dialyses, Tenon Hospital, AP-HP, Paris, France; ANDRA, B Braun, Paris, France. Electronic address:

Front Med (Lausanne) 2020 2;7:582272. Epub 2021 Mar 2.

Nephrology, Dialysis and Transplantation Unit, Department of Emergency and Organ Transplantation, University of Bari, Bari, Italy.

Acute kidney injury (AKI) is increasingly emerging as a global emergency. Sepsis, major surgery, and nephrotoxic drugs are the main causes of AKI in hospitalized patients. However, glomerulonephritis accounts for about 10% of AKI episodes in adults, mainly related to rapidly progressive glomerulonephritis resulting from granulomatous polyangiitis (GPA, Wegener granulomatosis), microscopic polyangiitis (MPA), and anti-glomerular basement membrane (GBM) disease. Read More

Kidney Int Rep 2021 Mar 6;6(3):746-754. Epub 2021 Jan 6.

Service of Nephrology and Hypertension, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland.

Introduction: Myelodysplastic syndromes (MDS) are characterized by a high prevalence of associated autoimmune manifestations. Kidney involvement has been rarely reported in MDS patients. We report on the spectrum of kidney pathological findings in MDS patients. Read More

Z Gastroenterol 2021 Mar 16. Epub 2021 Mar 16.

Klinik für Nieren- und Hochdruckerkrankungen, Diabetologie und Endokrinologie, Medizinische Fakultät der Otto-von-Guericke-Universität, Magdeburg, Deutschland.

Acute and chronic kidney disease concurs commonly with liver disease and is associated with a wide array of complications including dialysis dependency and increased mortality. Patients with liver disease or liver cirrhosis show a higher prevalence of chronic kidney disease. This is attributed to concomitant comorbidities, such as metabolic syndrome, chronic inflammation, hypercoagulability, hyperfibrinolysis, diabetes mellitus and dyslipidaemias. Read More

Mayo Clin Proc 2021 03;96(3):577-591

Division of Nephrology and Infectious Diseases, AZ Sint-Jan Brugge, Brugge, Belgium; Ghent University, Ghent, Belgium. Electronic address:

Objective: To describe the clinical and pathological phenotype of membranous nephropathy (MN) associated with M-type-phospholipase-A-receptor (PLAR), thrombospondin-type-1-domain-containing-7A (THSD7A), semaphorin 3B (SEMA3B), neural-epidermal-growth-factor-like-1-protein (NELL-1), protocadherin 7 (PCDH7), exostosin 1/exostosin 2 (EXT1/EXT2) and neural cell adhesion molecule 1 (NCAM-1) as target antigens.

Methods: A retrospective cohort of 270 adult patients with biopsy-proven MN diagnosed between January 2015 and April 2020 was classified as PLAR-, THSD7A-, SEMA3B-, NELL-1-, PCDH7-, EXT1/EXT2-, NCAM-1-associated or septuple-negative MN using serologic tests, immunostaining, and/or mass spectrometry. Clinical, biochemical, pathologic, and follow-up data were systematically abstracted from the medical records, including disease activity of conditions traditionally associated with MN and occurring within 5 years of MN diagnosis. Read More