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Int Urol Nephrol 2021 May 15. Epub 2021 May 15.

Nephrology Clinic, Dialysis and Renal Transplant Center, 'C.I. Parhon' University Hospital, and "Grigore T. Popa" University of Medicine, Iasi, Romania.

Purpose: The aim of this retrospective study was: to analyze the epidemiological patterns of the kidney disease based on clinical and histological features in a single-center in the N-E region of Romania, between 2011 and 2019 and to compare the biopsy results with the others periods, as well as the results from other countries.

Methods: We studied 442 renal biopsies. The indications for renal biopsy were represented by the clinical features: nephrotic syndrome, nephritic syndrome, asymptomatic urinary abnormalities, acute kidney injury, and chronic kidney disease of unknown etiology. Read More

Ren Fail 2021 Dec;43(1):851-859

The Department of Nephropathy, The Second Hospital of Jilin University, Changchun, China.

Purpose: To identify the clinical characteristics, histopathological features, and prognosis of kidney disease in a large cohort of elderly patients from Northeast China.

Methods: We retrospectively analyzed the renal disease spectrum in 7,122 patients who underwent renal biopsies at the Second Hospital of Jilin University from 2006 to 2020. Patients were grouped according to age: below 60 years (non-elderly group,  = 5923) and at least 60 years (elderly group,  = 1199). Read More

Cureus 2021 Apr 5;13(4):e14294. Epub 2021 Apr 5.

Department of Medicine, Dr Soliman Fakeeh Hospital, Jeddah, SAU.

The renal complications of dengue virus infection cover a wide spectrum of manifestations from acute kidney injury to glomerular injury with nephritic/nephrotic syndrome. Majority of cases remain symptom free and show full recovery. We present a 61-year-old previously healthy male who developed a pyrexial illness with haemolytic anaemia that was diagnosed on the basis of a positive serological test as a case of dengue fever. Read More

Eur J Ophthalmol 2021 May 2:11206721211014384. Epub 2021 May 2.

Eye Clinic, Polytechnic University of Marche, Ancona, Italy.

Purpose: To report our experience with a peculiar case of asynchronous bilateral retinal vascular occlusion in a patient suffering from membranoproliferative glomerulonephritis.

Case Report: A 57-year-old dialysed male affected by membranoproliferative glomerulonephritis who underwent kidney transplantation complained of a sudden vision loss in his right eye (RE). His best-corrected visual acuity (BCVA) was 20/40 in RE and 20/20 in the left eye (LE); ophthalmological and fluorangiographic examinations revealed unilateral retinal obliterative vasculitis with panuveitis and apparent sparing of contralateral eye. Read More

CEN Case Rep 2021 Apr 27. Epub 2021 Apr 27.

The Second Department of Internal Medicine, University of Toyama, 2630 Sugitani, Toyama, Toyama, 930-0194, Japan.

We had a 72-year-old man with advanced gastric cancer, poorly differentiated adenocarcinoma, receiving chemotherapy with S-1 (tegafur, gimeracil, and oteracil potassium) plus oxaliplatin. Ascites developed despite remission of gastric cancer and metastasis. Given no malignant cells in ascites, leg edema, renal impairment, hypoalbuminemia, and massive proteinuria, we diagnosed as nephrotic syndrome with microscopic hematuria. Read More

BMJ Case Rep 2021 Apr 23;14(4). Epub 2021 Apr 23.

Division of Nephrology, Department of Medicine, University of the Philippines Manila, Manila, Philippines.

Crescentic glomerulonephritis is usually associated with an acute nephritic syndrome with rapidly declining renal function. Postinfectious cases usually have a higher possibility of recovery. Juvenile nasopharyngeal angiofibroma (JNA) is a rare, locally aggressive tumour affecting mostly young men. Read More

BMC Nephrol 2021 Apr 21;22(1):143. Epub 2021 Apr 21.

Renal Division, Department of Medicine, West China Hospital of Sichuan University, 610041, Chengdu, China.

Background: C3 glomerulopathy (C3G) is a recent disease classification that is characterized by the presence of glomerular deposits (composed of C3) in the absence of significant amounts of immunoglobulin and comprises dense deposit disease and C3 glomerulonephritis (C3GN). Most C3GN manifests as membranoproliferative, mesangial proliferative glomerulonephritis patterns via light microscopy. Pure membranous nephropathy (MN)-like glomerular lesions are rare manifestations of C3GN. Read More

World J Clin Cases 2021 Apr;9(10):2357-2366

Department of Nephrology, Shenzhen Longhua District Central Hospital, Shenzhen 518110, Guangdong Province, China.

Background: Proliferative glomerulonephritis with monoclonal immunoglobulin G (IgG) deposits (PGNMID) is a newly recognized rare disease. The renal pathology is characterized by prominent manifestations of membranous hyperplasia, which are easy to misdiagnose. The clinical symptoms are severe. Read More

Indian J Pathol Microbiol 2021 Apr-Jun;64(2):282-287

Department of Anatomy, IPGMER and SSKM Hospital, Kolkata, West Bengal, India.

Background: Proliferative glomerulonephritis with monoclonal immunoglobulin deposit (PGNMID) is an entity with a variable clinical and histological spectrum, which mimics immune-complex mediated glomerulonephritis on light microscopy. In this article, we aim to describe the clinical and pathological features of six cases of PGNMID that we encountered during our routine practice.

Materials And Methods: The study was of the prospective type carried out from February 2018 to August 2019. Read More

CEN Case Rep 2021 Apr 13. Epub 2021 Apr 13.

Department of Nephrology, Yokosuka Kyosai Hospital, 1-16 Yonegahamadori, Yokosuka, Kanagawa, 238-8558, Japan.

We report a case of immunotactoid glomerulonephritis (ITG) in a patient with cold agglutinins. An 86-year-old Japanese male with a history of hypertension, dyslipidemia, and gastric malignancy presented to our hospital for the evaluation of proteinuria and hematuria. He had an elevated blood pressure of 200/77 mmHg and edema of the lower extremities. Read More

Indian J Nephrol 2020 Nov-Dec;30(6):370-376. Epub 2020 Feb 7.

Department of Pathology, Jaslok Hospital and Medical Research Institute, Mumbai, Maharashtra, India.

Introduction: There is paucity of data of C3 glomerulopathy in Indian children.

Methods: First Indian pediatric case series where consecutive renal biopsies done over a period of ten years were reviewed to identify those patients who had isolated or predominant C3 deposits on immunofluorescent microscopy, fulfilling the criteria for C-3 glomerulopathy. The clinical, biochemical, serological, histopathological profile, eGFR and the need for renal replacement therapy was analyzed. Read More

Indian J Nephrol 2020 Nov-Dec;30(6):359-369. Epub 2020 Nov 30.

Division of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota, USA.

Renal transplantation is the preferred form of renal replacement therapy in patients who develop end-stage kidney disease (ESKD). Among the diverse etiologies of ESKD, glomerulonephritis is the third most common cause, behind hypertensive and diabetic kidney disease. Although efforts to prolong graft survival have improved over time with the advent of novel immunosuppression, recurrent glomerulonephritis remains a major threat to renal allograft survival despite concomitant immunosuppression. Read More

Nefrologia 2021 Apr 3. Epub 2021 Apr 3.

Nephrology Department, Carlos Haya Regional University Hospital and University of Malaga, IBIMA, REDinREN (RD16/0009/0006), Malaga, Spain. Electronic address:

Monoclonal gammopathy of renal significance is a clinical-pathological entity grouping renal disorders secondary to the secretion of a monoclonal immunoglobulin synthesized by a B-cell-derived clone and/or plasma cells in a patient with no diagnostic criteria for multiple myeloma. This term applies to a concept recently introduced owing to the need to differentiate this entity from monoclonal gammopathy of undetermined significance, given the negative prognostic impact of its high morbidity and mortality resulting from both renal and systemic involvement, occasionally even progressing to advanced chronic kidney disease. The renal damage occurs via both direct pathogenic mechanisms, with the deposition of the monoclonal protein in different renal structures, as well as indirect mechanisms, acting as an autoantibody provoking dysregulation of the alternative complement pathway. Read More

Front Pediatr 2021 17;9:647364. Epub 2021 Mar 17.

Department of Nephrology, National Clinical Research Center for Child Health, National Children's Regional Medical Center, The Children's Hospital, Zhejiang University School of Medicine, Hangzhou, China.

This report describes an 8-year-old male who presented with clinical manifestations including systemic edema, heavy proteinuria, hypoproteinemia, and persistent hypocomplementemia. Arachnoid cysts and focal nodular hyperplasia were also detected. Imaging examination and renal biopsy were performed, and Abernethy malformation type II with immune complex-mediated membranoproliferative glomerulonephritis was considered the diagnosis. Read More

Mol Genet Genomic Med 2021 Mar 29:e1658. Epub 2021 Mar 29.

Laboratoire d'ImmunoRhumatologie Moléculaire, plateforme GENOMAX, INSERM UMR_S 1109, Faculté de Médecine, Fédération Hospitalo-Universitaire OMICARE, Fédération de Médecine Translationnelle de Strasbourg (FMTS), Institut thématique interdisciplinaire (ITI) de Médecine de Précision de Strasbourg, Transplantex NG, Université de Strasbourg, Strasbourg, France.

Background: Podocalyxin (PODXL) is a highly sialylated adhesion glycoprotein that plays an important role in podocyte's physiology. Recently, missense and nonsense dominant variants in the PODXL gene have been associated with focal segmental glomerulosclerosis (FSGS), a leading cause of nephrotic syndrome and kidney failure. Their histologic description, however, was superficial or absent. Read More

Am J Kidney Dis 2021 Mar 24. Epub 2021 Mar 24.

Departments of Nephrology; Department of Medicine (RMH), University of Melbourne, Victoria, Australia.

There is increasing recognition of monoclonal gammopathy as a cause of proliferative glomerulonephritis (GN), including cases in which glomerular deposition of monoclonal immunoglobulin (mIg) is demonstrated. Recently, proliferative GN with mIg deposits (PGNMID) has incorporated a light chain (LC) variant of the disease (termed PGNMID-LC). Intriguingly, glomerular co-deposition of complement C3 is found in addition to monotypic LC, implying complement activation via the alternative pathway (AP). Read More

Pediatr Nephrol 2021 Mar 25. Epub 2021 Mar 25.

Pediatric Rheumatology Department, University of Health Sciences, Umraniye Training and Research Hospital, Istanbul, Turkey.

Pediatr Nephrol 2021 Mar 25. Epub 2021 Mar 25.

Pediatric Rheumatology Department, University of Health Sciences, Umraniye Training and Research Hospital, Istanbul, Turkey.

Curr Opin Nephrol Hypertens 2021 May;30(3):310-316

Department of Immunology and Inflammation, Faculty of Medicine, Imperial College London, UK.

Purpose Of Review: In this review, we discuss recent studies showing the importance of the complement pathway in kidney disease.

Recent Findings: Recent findings in C3 glomerulopathy (C3G) include: acute postinfectious glomerulonephritis is characterised by the presence of antifactor B antibodies; human leukocyte antigen type, but not rare complement gene variation, is associated with primary immunoglobulin-associated membranoproliferative GN and C3G. Immunohistochemistry in C3G shows that factor H related protein 5 (FHR5) is the most prevalent complement protein and correlates with kidney function. Read More

Cureus 2021 Feb 14;13(2):e13338. Epub 2021 Feb 14.

Internal Medicine, All India Institute of Medical Sciences, Bhubaneswar, IND.

Schnitzler syndrome (SS) is a rare disease of unknown etiology. Literature suggests that only around 300 well-diagnosed cases have only been reported worldwide and rarely from India. This syndrome has a slight male predominance with a mean age of onset of around 50 years. Read More

J Nephrol 2021 Mar 17. Epub 2021 Mar 17.

Dipartimento di Medicina Generale e Specialistica, U.O. Nefrologia, Azienda Ospedaliero-Universitaria di Parma, Via Gramsci, 14, 43126, Parma, Italy.

Z Gastroenterol 2021 Mar 16. Epub 2021 Mar 16.

Klinik für Nieren- und Hochdruckerkrankungen, Diabetologie und Endokrinologie, Medizinische Fakultät der Otto-von-Guericke-Universität, Magdeburg, Deutschland.

Acute and chronic kidney disease concurs commonly with liver disease and is associated with a wide array of complications including dialysis dependency and increased mortality. Patients with liver disease or liver cirrhosis show a higher prevalence of chronic kidney disease. This is attributed to concomitant comorbidities, such as metabolic syndrome, chronic inflammation, hypercoagulability, hyperfibrinolysis, diabetes mellitus and dyslipidaemias. Read More

JIMD Rep 2021 Mar 6;58(1):122-128. Epub 2021 Jan 6.

Department of Pediatrics Center for Metabolic Diseases, University Hospitals Leuven Leuven Belgium.

Recently, a disorder caused by the heterozygous de novo c.1267C>T (p.R423*) substitution in has been described. Read More

Front Immunol 2021 25;12:580271. Epub 2021 Feb 25.

Department of Rheumatology, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Science, Beijing, China.

This study aimed to describe the main characteristics of Chinese patients with cryoglobulinemia, especially the characteristics of patients with different causes of cryoglobulinemia. Eighty inpatients diagnosed with cryoglobulinemia from different wards in Peking Union Medical College Hospital were included in this study. Demographic, clinical, biological, and renal pathological data were collected. Read More

Int J Mol Sci 2021 Feb 19;22(4). Epub 2021 Feb 19.

The Department of Biomedical Engineering, University of Houston, Houston, TX 77204-5060, USA.

The 129sv mouse strain is particularly sensitive to experimental immune-mediated nephritis. Previous studies have indicated that transforming growth factor-β (TGF-β) plays a critical role in both immune modulation and tissue fibrogenesis in various diseases and that its biological activities are exerted via the SMAD family. In this study, we aimed to determine whether TGF-β/SMAD signaling is essential for the development of immune-mediated nephritis in 129sv mice. Read More

CEN Case Rep 2021 Mar 3. Epub 2021 Mar 3.

Department of Nephrology and Blood Purification, Kidney Disease Center, Tokyo Medical University Hachioji Medical Center, 1163 Tatemachi, Hachioji, Tokyo, 193-0998, Japan.

A 74-year-old Japanese woman was referred to our department because of anasarca and massive proteinuria. She was clinically diagnosed with nephrotic syndrome, and renal biopsy showed membranoproliferative glomerulonephritis accompanied by marked glomerular infiltration with macrophages and full-house immunofluorescence glomerular deposition. Furthermore, randomly arranged nonbranching fibrils, approximately 12 nm in diameter, were found by electron microscopy, and immunostaining for DnaJ homolog subfamily B member 9 (DNAJB9), a recently identified diagnostic biomarker of fibrillary glomerulonephritis (FGN), showed positive result, thereby confirming the diagnosis of FGN. Read More

Nefrologia 2021 Feb 27. Epub 2021 Feb 27.

Hospital General Universitario de Elche, Alicante, España.

Front Pediatr 2020 4;8:568773. Epub 2021 Feb 4.

Department of Pediatric Nephrology, Lanzhou University Second Hospital, Lanzhou, China.

C1q nephropathy is a glomerulopathy that is characterized by large amount of C1q deposits in the glomerular mesangium. It is a diagnosis of exclusion after ruling out systemic lupus erythematosus and membranoproliferative glomerulonephritis by systemic and serological examination. The pathogenesis of C1q nephropathy is unclear. Read More

Am J Clin Pathol 2021 Feb 24. Epub 2021 Feb 24.

Department of Pathology, Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN, USA.

Objectives: To study the pathologic spectrum of kidney diseases in patients with hepatitis C virus infection (HCV+).

Methods: Native kidney biopsy specimens in HCV+ patients were reviewed.

Results: A total of 9,836 native kidney biopsy specimens were evaluated from January 2007 to December 2016, of which 273 (2. Read More

Clin Kidney J 2021 Feb 25;14(2):586-592. Epub 2020 Jan 25.

Department of Nephrology, University Hospital Gregorio Marañón, Madrid, Spain.

Background: Direct-acting antiviral agents (DAAs) have shown high rates of sustained virological response in chronic hepatitis C virus (HCV) infection. However, the influence of DAAs on the course of kidney involvement in HCV-associated mixed cryoglobulinaemia (HCV-MC) has been little studied. The aim of this study was to analyse the effects of antiviral treatment on kidney prognosis and evolution in patients diagnosed with HCV-MC. Read More