2,454 results match your criteria Glomerulonephritis Crescentic


Neutrophil Gelatinase-Associated Lipocalin Protects from ANCA-Induced GN by Inhibiting T17 Immunity.

J Am Soc Nephrol 2020 Jun 2. Epub 2020 Jun 2.

Experimental and Clinical Research Center, Max Delbrück Center for Molecular Medicine and Charité - Berlin University of Medicine, Corporate Member of Free University of Berlin, Humboldt University of Berlin, Berlin Institute of Health, Berlin, Germany.

Background: Neutrophil gelatinase-associated lipocalin (NGAL) is a diagnostic marker of intrinsic kidney injury produced by damaged renal cells and by neutrophils. ANCA-associated vasculitis features necrotizing crescentic GN (NCGN), and ANCA-activated neutrophils contribute to NCGN. Whether NGAL plays a mechanistic role in ANCA-associated vasculitis is unknown. Read More

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http://dx.doi.org/10.1681/ASN.2019090879DOI Listing

Rituximab in severe immunoglobulin-A vasculitis (Henoch-Schönlein) with aggressive nephritis.

Clin Exp Rheumatol 2020 Mar-Apr;38 Suppl 124(2):195-200. Epub 2020 May 22.

CMID-Nephrology and Dialysis Unit, Center of Research of Rheumatologic, Nephrologic and Rare Diseases, and Coordinating Centre of the Network for Rare Diseases of Piedmont and Aosta Valley, San Giovanni Bosco Hospital and University of Turin, Italy.

Objectives: Immunoglobulin-A vasculitis (IgAV) is a systemic small-vessel vasculitis in which renal involvement indicates severity of illness, and chronic kidney disease represents the most serious long-term complication. No treatment at present is specifically recommended for IgAV. Recently, rituximab (RTX) has been shown to be effective in case series of adults with IgAV. Read More

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Antibody-mediated rejection with the presence of glomerular crescents in a pediatric kidney transplant recipient: A case report.

Pediatr Transplant 2020 May 21:e13722. Epub 2020 May 21.

Pediatric Nephrology Department, Panagiotis & Aglaia Kyriakou Children's Hospital, Athens, Greece.

Glomerular crescents in kidney transplantation are indicative of severe glomerular injury and constitute a hallmark of RPGN. Their concurrence with ABMR has been rarely described only in adult patients. We report a case of 10-year-old boy with compound heterozygous Fin-major Finnish-type congenital nephrotic syndrome, who had received a deceased-donor kidney transplant 5 years before onset of acute kidney injury and nephrotic range proteinuria without hematuria. Read More

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http://dx.doi.org/10.1111/petr.13722DOI Listing

Narrative Review of Hypercoagulability in Small-Vessel Vasculitis.

Kidney Int Rep 2020 May 13;5(5):586-599. Epub 2020 Jan 13.

Department of Internal Medicine, Section on Nephrology, Wake Forest School of Medicine, Winston Salem, North Carolina, USA.

Pauci-immune necrotizing and crescentic glomerulonephritis (GN) is the most common etiology of rapidly progressive GN. Clinical presentation in those afflicted is usually related to rapid loss of kidney function. We report the case of a 70-year-old woman who came to medical attention for signs and symptoms related to lower-extremity deep vein thrombosis (DVT). Read More

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http://dx.doi.org/10.1016/j.ekir.2019.12.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7210611PMC

Atypical Anti-Glomerular Basement Membrane Disease With Diffuse Crescentic Membranoproliferative Glomerulonephritis: Case Report and Review of Literature.

Qatar Med J 2020 5;2020(1):16. Epub 2020 May 5.

Division of Nephrology, Department of Medicine, Hamad Medical Corporation, Doha, Qatar.

Anti-glomerular basement membrane (anti-GBM) disease occurs in fewer than two cases per million population. Patients usually present with features of rapidly progressive glomerulonephritis (RPGN) with or without pulmonary involvement. Anti-GBM disease is classically diagnosed by both demonstrating GBM linear immunofluorescence staining on kidney biopsy and detecting anti-GBM antibodies in serum. Read More

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http://dx.doi.org/10.5339/qmj.2020.16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7199789PMC

Newly Diagnosed Glomerulonephritis During COVID-19 Infection Undergoing Immunosuppression Therapy, a Case Report.

Iran J Kidney Dis 2020 05;14(3):239-242

Medical School, Isfahan University of Medical Sciences, Isfahan, Iran.

During the COVID-19 pandemic, we had a 25 years old male case without any underlying disease or history of autoimmune disease in COVID-19 Clinic, Isfahan, Iran. He presented with arthralgia and weakness so we started COVID-19 therapeutic regimen. In his hospitalization, creatinine increases and abnormalities in random urine sediment was seen. Read More

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IgA vasculitis and anti-GBM disease: two ends of a spectrum of immune complex vasculitis.

Authors:
Alan D Salama

Rheumatology (Oxford) 2020 May;59(Supplement_3):iii118-iii122

UCL Department of Renal Medicine, Royal Free Hospital, London, UK.

Two immune complex vasculitides, IgA vasculitis (IgAV) and anti-GBM disease, represent polar extremes with regard to our understanding of disease pathogenesis, standardized management protocols and outcomes. This report compares our current approach to these uncommon entities in adults. Both diseases demonstrate degrees of small vessel necrosis and glomerular crescent formation. Read More

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http://dx.doi.org/10.1093/rheumatology/kez540DOI Listing

Anti-glomerular basement membrane disease: A clinicomorphological study of 16 cases.

Indian J Pathol Microbiol 2020 Apr-Jun;63(2):226-229

Department of Nephrology, Nizam's Institute of Medical Sciences, Punjagutta, Hyderabad, Telangana, India.

Introduction: Antiglomerular basement membrane disease manifests as rapidly progressive glomerulonephritis and alveolar hemorrhage. It encompasses 10-15% of crescentic glomerulonephritis and is associated with poor outcome. In this study, we have elaborated on the clinical details, morphological features, and outcome of anti-GBM glomerulonephritis. Read More

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http://dx.doi.org/10.4103/IJPM.IJPM_712_18DOI Listing

The Presence of Renal IgG Deposits in Necrotizing Crescentic Glomerulonephritis Associated with ANCA Is Not Related to Worse Renal Clinical Outcomes.

Kidney Dis (Basel) 2020 Mar 21;6(2):98-108. Epub 2019 Nov 21.

Department of Nephrology - Hypertension, Dialysis, Transplantation, CHRU, Tours, France.

Introduction: Classical pauci-immune necrotizing crescentic glomerulonephritis (CGN) associated with antineutrophil cytoplasmic autoantibodies (ANCA) is characterized by the absence of renal immunoglobulin (Ig) deposits. However, IgG deposits can sometimes be present. We wanted to assess whether necrotizing CGN with IgG deposits is associated with a more severe presentation and outcome than necrotizing CGN without IgG deposits. Read More

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http://dx.doi.org/10.1159/000503969DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7154286PMC

Spleen tyrosine kinase inhibition is an effective treatment for established vasculitis in a pre-clinical model.

Kidney Int 2020 Jun 16;97(6):1196-1207. Epub 2020 Jan 16.

Centre for Inflammatory Disease, Department of Medicine, Imperial College London, London UK.

The anti-neutrophil cytoplasm antibody (ANCA)-associated vasculitides (AAV) are a group of life-threatening multi-system diseases characterized by necrotising inflammation of small blood vessels and crescentic glomerulonephritis. ANCA are thought to play a direct pathogenic role. Previous studies have shown that spleen tyrosine kinase (SYK) is phosphorylated during ANCA-induced neutrophil activation in vitro. Read More

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http://dx.doi.org/10.1016/j.kint.2019.12.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7242903PMC

Human leucocyte antigen-associated anti-glomerular basement membrane disease in siblings.

Clin Kidney J 2020 Apr 3;13(2):261-262. Epub 2019 Jun 3.

Department of Renal Medicine, Royal Preston Hospital, Preston, UK.

We report a case of anti-glomerular basement membrane (GBM) disease in association with human leucocyte antigen (HLA) DRB1 15:01. A 71-year-old woman presented with oligoanuric acute kidney injury accompanied by high titre anti-GBM antibodies. Renal biopsy revealed a severe crescentic glomerulonephritis. Read More

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http://dx.doi.org/10.1093/ckj/sfz058DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7147311PMC

Hydralazine-induced antineutrophil cytoplasmic antibody-associated vasculitis with pulmonary-renal syndrome: a case report.

J Med Case Rep 2020 Apr 15;14(1):47. Epub 2020 Apr 15.

Section of Critical Care, Department of Medicine, Saint Agnes Hospital, Baltimore, MD, USA.

Background: Hydralazine is a common vasodilator which has been used for the treatment of hypertension and heart failure. Hydralazine can induce antineutrophil cytoplasmic antibody-associated vasculitis due to its auto-immunogenic capability and one of the very rare presentations is pulmonary-renal syndrome.

Case Presentation: We report a case of a 64-year-old African American woman, who presented to our emergency room with shortness of breath, orthopnea, paroxysmal nocturnal dyspnea, leg swelling, fatigue, loss of appetite, cough with clear sputum, and lightheadedness. Read More

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http://dx.doi.org/10.1186/s13256-020-02378-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7158156PMC

Fibrillary Glomerulopathy with a High Level of Myeloperoxidase-ANCA: A Case Report.

Case Rep Nephrol 2020 23;2020:6343521. Epub 2020 Mar 23.

Department of Internal Medicine, Suwa Central Hospital, Chino, Nagano 391-8503, Japan.

An elderly woman was admitted with the chief complaint of gross hematuria. Laboratory values indicated a high myeloperoxidase-ANCA level. In renal histological examination, 40% of the glomeruli showed crescent formation, but immunofluorescence staining showed positivity for IgG, C3, and C1q. Read More

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http://dx.doi.org/10.1155/2020/6343521DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7128069PMC

Parietal epithelial cells role in repair versus scarring after glomerular injury.

Curr Opin Nephrol Hypertens 2020 May;29(3):293-301

PARCC, INSERM, Université de Paris.

Purpose Of Review: The recent years have been marked by the publication of several articles highlighting the pathophysiological role of glomerular parietal epithelial cells (PEC) and refining their phenotypic heterogeneity.

Recent Findings: The present review synthetizes recent findings on (i) the potential regenerative role of PEC in glomerular diseases, and (ii) the mechanisms and signaling of leading to PEC pathogenic involvement in crescentic glomerulonephritis (CGN) and focal segmental glomerulosclerosis (FSGS).

Summary: The debate is still open regarding the podocyte regenerative properties of PEC in glomerular disease, whereas the pathogenic involvement of PEC activation in glomerular disease is increasingly admitted. Read More

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http://dx.doi.org/10.1097/MNH.0000000000000600DOI Listing

Rare case of post-varicella membranoproliferative glomerulonephritis presenting with massive proteinuria.

BMJ Case Rep 2020 Mar 12;13(3). Epub 2020 Mar 12.

Internal Medicine, King George's Medical University, Lucknow, Uttar Pradesh, India.

Chicken pox caused by varicella zoster virus is usually a self-limiting disease causing rare life-threatening complications. Involvement of the kidneys is infrequent during the course of the illness. Literature shows rare reports of acute glomerulonephritis following varicella infection. Read More

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http://dx.doi.org/10.1136/bcr-2019-233084DOI Listing

Clinicopathological Significance and Renal Outcomes of Light Microscopic Patterns in Complement Component 3 Glomerulopathy.

Nephron 2020 10;144(5):228-235. Epub 2020 Mar 10.

Department of Pathology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India.

Background: Complement component 3 glomerulopathy (C3G) is a disease diagnosed based on the predominance of C3 immunostaining in glomeruli. The popular electron microscopic subtyping of C3G into dense deposit disease and C3 glomerulonephritis (GN) is not without limitations. We aimed to study the light microscopic (LM) patterns of C3G along with their clinicopathological correlation and treatment outcome. Read More

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http://dx.doi.org/10.1159/000506290DOI Listing

Therapeutic Potential of Thrombomodulin in Renal Fibrosis of Nephrotoxic Serum Nephritis in Wistar-Kyoto Rats.

Kidney Blood Press Res 2020 6;45(3):391-406. Epub 2020 Mar 6.

Division of Nephrology, Department of Medicine, Showa University School of Medicine, Tokyo, Japan.

Background: Recombinant human soluble thrombomodulin (rhTM) was approved in 2008 and has been used for treatment of disseminated intravascular coagulation in Japan. The antifibrotic effects of rhTM in acute exacerbation of idiopathic pulmonary fibrosis are well established, but the therapeutic potential of rhTM in renal fibrosis remains poorly understood.

Methods: Nephrotoxic serum nephritis (NTS-N) was induced in 22 female Wistar-Kyoto (WKY) rats on day 0. Read More

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http://dx.doi.org/10.1159/000506286DOI Listing

The glomerular crescent: triggers, evolution, resolution, and implications for therapy.

Curr Opin Nephrol Hypertens 2020 May;29(3):302-309

Renal Division, Department of Medicine IV, University Hospital of the Ludwig Maximilian University, Munich, Germany.

Purpose Of Review: Crescents are classical histopathological lesions found in severe forms of rapidly progressive glomerulonephritis, also referred to as crescentic glomerulonephritis (CGN). Crescent formation is a consequence of diverse upstream pathomechanisms and unraveling these mechanisms is of great interest for improving the management of patients affected by CGN. Thus, in this review, we provide an update on the latest insight into the understanding on how crescents develop and how they resolve. Read More

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http://dx.doi.org/10.1097/MNH.0000000000000596DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7170443PMC

Predictors of renal outcomes in anti-neutrophil cytoplasmic antibody glomerulonephritis.

Saudi J Kidney Dis Transpl 2020 Jan-Feb;31(1):182-190

Department of Nephrology, Dialysis and Transplantation, La Rabta Hospital, Tunis, Tunisia.

Glomerulonephritis associated with anti-neutrophil cytoplasmic antibody (ANCA) vasculitis still has a high prevalence of end-stage renal disease (ESRD), particularly in patients with advanced renal failure at presentation. This study aims to evaluate the clinical and histo- pathological features of renal involvement and investigate factors associated with ESRD. Patients with renal biopsy-proven ANCA-associated glomerulonephritis were included retrospectively over a period of nine years (June 2007 to March 2016). Read More

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http://dx.doi.org/10.4103/1319-2442.279939DOI Listing

Sex and Glomerular Filtration Rate Trajectories in Children.

Clin J Am Soc Nephrol 2020 Mar 28;15(3):320-329. Epub 2020 Feb 28.

Department of Pediatric Nephrology, Robert Debré Hospital, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France;

Background And Objectives: Differences in CKD progression by sex have been hypothesized to explain disparities in access to kidney transplantation in children. This study aims to identify distinct trajectories of eGFR decline and to investigate the association of sex with eGFR decline.

Design, Setting, Participants, & Measurements: We used data from the CKD in Children study. Read More

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http://dx.doi.org/10.2215/CJN.08420719DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7057295PMC

Crescentic IgA nephropathy after administration of human monoclonal interleukin-12/23p40 antibody in a patient with Crohn's disease: a case report.

CEN Case Rep 2020 Feb 25. Epub 2020 Feb 25.

Division of Nephrology, Department of Medicine, Showa University School of Medicine, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo, 142-8666, Japan.

Ustekinumab (UST), an interleukin (IL)-12/IL-23-blocking monoclonal antibody, is a novel therapeutic option for Crohn's disease (CD). We describe a 24-year-old man with CD who showed an abrupt decline in renal function after administration of UST. Twenty-nine months previously, the patient was diagnosed with CD, and abnormal urinalysis findings in health checkup were coincidentally found at that time. Read More

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http://dx.doi.org/10.1007/s13730-020-00457-xDOI Listing
February 2020

Intravenous (IV) cefazolin with oral probenecid: A novel daily regimen for the management of Methicillin Sensitive Staphylococcus aureus (MSSA) bacteremia in a patient with renal dysfunction.

IDCases 2020 29;19:e00706. Epub 2020 Jan 29.

Department of Pharmacy, Yale New Haven Hospital, United States.

A 78 year old man developed a methicillin sensitive (MSSA) post-operative wound infection following an elective L2-L4 laminectomy. He was treated with surgical debridement which was to be followed by a planned 6 weeks course of cefazolin. However, two weeks post debridement, a follow-up MRI revealed an L3-L5 epidural abscess, septic arthritis and vertebral osteomyelitis prompting repeat surgical debridement. Read More

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http://dx.doi.org/10.1016/j.idcr.2020.e00706DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7005544PMC
January 2020

Crescentic glomerulonephritis in children.

Pediatr Nephrol 2020 May 12;35(5):829-842. Epub 2020 Feb 12.

Department of Pediatric Kidney, Liver and Metabolic Diseases, Hannover Medical School, Carl-Neuberg-Strasse 1, 30625, Hannover, Germany.

Background: To date, there is insufficient knowledge about crescentic glomerulonephritis (cGN), the most frequent immunologic cause of acute kidney injury in children.

Methods: Over a period of 16 years, we retrospectively analyzed kidney biopsy results, the clinical course, and laboratory data in 60 pediatric patients diagnosed with cGN.

Results: The underlying diseases were immune complex GN (n = 45/60, 75%), including IgA nephropathy (n = 19/45, 42%), lupus nephritis (n = 10/45, 22%), Henoch-Schoenlein purpura nephritis (n = 7/45, 16%) and post-infectious GN (n = 7/45, 16%), ANCA-associated pauci-immune GN (n = 10/60, 17%), and anti-glomerular basement-membrane GN (n = 1/60, 2%). Read More

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http://dx.doi.org/10.1007/s00467-019-04436-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7096391PMC

Autoimmune polyglandular syndrome type III associated with antineutrophil cytoplasmic autoantibody-mediated crescentic glomerulonephritis: A case report and literature review.

Medicine (Baltimore) 2020 Feb;99(7):e19179

Department of VIP Unit, China-Japan Union Hospital of Jilin University, Changchun, China.

Rationale: Polyglandular autoimmune syndromes (PAS) are a heterogeneous group of rare diseases characterized by the association of at least 2 organ-specific autoimmune disorders, concerning both the endocrine and nonendocrine organs. Type III is defined as the combination of autoimmune thyroid disease and other autoimmune conditions (other than Addison disease), and is divided into 4 subtypes. We describe a patient with Hashimoto thyroiditis, adult-onset Still disease, alopecia, vasculitis, antineutrophil cytoplasmic antibody (ANCA)-mediated crescentic glomerulonephritis, and hyperparathyroidism. Read More

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http://dx.doi.org/10.1097/MD.0000000000019179DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7035075PMC
February 2020
5.723 Impact Factor

Granulomatous Interstitial Nephritis - A Series of Six Cases.

Indian J Nephrol 2020 Jan-Feb;30(1):26-28. Epub 2019 Dec 27.

Department of Nephrology, IPGMER and SSKM Hospital, Kolkata, West Bengal, India.

Granulomatous interstitial nephritis is an uncommon variant accounting for about 6% of all tubulointerstitial nephritis. The etiology can be drugs such as antibiotics and nonsteroidal anti-inflammatory drugs and infections such as tuberculosis, sarcoidosis, and fungal infections. Renal biopsy remains the gold standard for establishing the diagnosis. Read More

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http://dx.doi.org/10.4103/ijn.IJN_364_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6977373PMC
December 2019

Diagnostic and treatment challenge of unrecognized subacute bacterial endocarditis associated with ANCA-PR3 positive immunocomplex glomerulonephritis: a case report and literature review.

BMC Nephrol 2020 Jan 31;21(1):40. Epub 2020 Jan 31.

Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.

Background: Diagnosis and treatment of either ANCA disease or silent infection-related glomerulonephritis is complicated and is a huge treatment challenge when overlapping clinical manifestations occur. We report a case of ANCA-PR3 glomerulonephritis, nervous system involvement, hepatosplenomegaly and clinically silent subacute infectious endocarditis.

Case Presentation: A 57-year-old man with known mitral valve prolaps was admitted for unexplained renal failure with signs of nephritic syndrome, hepatosplenomegaly, sudden unilateral hearing loss, vertigo, malaise, new onset hemolytic anemia and thrombocytopenia. Read More

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http://dx.doi.org/10.1186/s12882-020-1694-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6995228PMC
January 2020

Successful simultaneous liver-kidney transplantation for renal failure associated with hereditary complement C3 deficiency.

Am J Transplant 2020 Jan 23. Epub 2020 Jan 23.

Institute of Liver Studies, King's College Hospital NHS Foundation Trust, London, UK.

Hereditary complement C3 deficiency is associated with recurrent bacterial infections and proliferative glomerulonephritis. We describe a case of an adult with complete deficiency of complement C3 due to homozygous mutations in C3 gene: c.1811delT (Val604Glyfs*2), recurrent bacterial infections, crescentic glomerulonephritis, and end-stage renal failure. Read More

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http://dx.doi.org/10.1111/ajt.15785DOI Listing
January 2020
5.683 Impact Factor

Validation of a renal risk score in a cohort of ANCA-associated vasculitis patients with severe kidney damage.

Clin Rheumatol 2020 Jun 22;39(6):1935-1943. Epub 2020 Jan 22.

Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Vasco de Quiroga No. 15, Col. Sección XVI, Tlalpan, 14000, Mexico, CP, Mexico.

Objective: To validate the renal risk score in a cohort of patients with advanced kidney damage.

Methods: A total of 72 patients with biopsy-proven ANCA glomerulonephritis with >12 months of follow-up were studied. The renal risk score was calculated and evaluated by survival analysis for time of renal survival. Read More

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http://dx.doi.org/10.1007/s10067-020-04936-5DOI Listing

Patterns in renal diseases diagnosed by kidney biopsy: A single-center experience.

Kidney Res Clin Pract 2020 Mar;39(1):60-69

Division of Nephrology, Department of Internal Medicine, School of Medicine, Kyungpook National University, Daegu, Republic of Korea.

Background: The worldwide incidence of renal disease diagnosed by a kidney biopsy varies with age, race, sex, and region. Owing to a lack of studies and limited research resources for this disease in Korea, we investigated renal disease patterns by analyzing data from kidney biopsies performed over 13 years in a university-based teaching hospital in Korea.

Methods: Among 2,053 kidney biopsies performed from 2001 to 2013 at Kyungpook National University Hospital, 1,924 were retrospectively analyzed for histopathologic, demographic, and clinical data as well as laboratory results. Read More

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http://dx.doi.org/10.23876/j.krcp.19.077DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7105626PMC

HHV-8-negative multicentric Castleman disease presenting as a crescentic immune complexes membranoproliferative glomerulonephritis.

BMJ Case Rep 2020 Jan 6;13(1). Epub 2020 Jan 6.

Nephrology, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland.

Multicentric Castleman disease is a rare polyclonal lymphoproliferative disorder mainly associated with two renal manifestations: thrombotic microangiopathy and amyloidosis. Nevertheless, we report here a case of human herpes virus-8 negative multicentric Castleman disease with membranous proliferative glomerulonephritis and extracapillary proliferation. A patient was successfully treated with corticosteroids, anti-CD20 and cyclophosphamide therapy. Read More

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http://dx.doi.org/10.1136/bcr-2019-231844DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6954780PMC
January 2020

Lupus Nephritis Class IV-Global Is Associated with a Higher Risk of End-Stage Renal Disease than Class IV-Segmental.

Nephron 2020 7;144(3):118-125. Epub 2020 Jan 7.

Department of Nephrology, Clinical Hospital, Federal University of Pernambuco, Recife, Brazil.

Introduction: The International Society of Nephrology/Renal Pathology Society (ISN/RPS) classification of lupus nephritis (LN) divides class IV into segmental and global (IV-S and IV-G) based on evidence suggesting different renal outcomes. However, subsequent studies have shown conflicting results.

Objective: This study was performed to compare long-term renal outcomes between the IV-S and IV-G classes. Read More

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http://dx.doi.org/10.1159/000505404DOI Listing
January 2020

Membranous Glomerulonephritis With Crescents.

Kidney Int Rep 2019 Nov 13;4(11):1577-1584. Epub 2019 Aug 13.

Centre for Inflammatory Disease, Division of Immunology and Inflammation, Department of Medicine, Imperial College London, London, UK.

Introduction: Membranous glomerulonephritis (MGN) is rarely associated with necrotizing and crescentic glomerulonephritis (NCGN).

Methods: We report the clinical and pathologic findings in 15 patients with MGN and NCGN associated with anti-neutrophil cytoplasm antibodies (ANCAs), anti-glomerular basement membrane (GBM), or anti-phospholipase A2 receptor (PLA2R) antibodies.

Results: The cohort consisted of 15 patients: 7 males and 8 females with a median age of 63 years (range: 18-79). Read More

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http://dx.doi.org/10.1016/j.ekir.2019.07.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6933443PMC
November 2019

Epidemiology and Pathophysiology of Glomerular C4d Staining in Native Kidney Biopsies.

Kidney Int Rep 2019 Nov 30;4(11):1555-1567. Epub 2019 Jul 30.

Department of Medicine, Division of Nephrology, University of Maryland School of Medicine, Baltimore, Maryland, USA.

Introduction: Routine C4d staining in renal transplantation has stimulated its use in kidney biopsies with glomerulonephritis (GN). Methodical description on staining patterns in the native kidney is not available.

Methods: We retrospectively evaluated C4d staining in formalin-fixed paraffin-embedded sections from 519 native kidney biopsies (bx) with and without glomerular disease. Read More

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http://dx.doi.org/10.1016/j.ekir.2019.07.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6933466PMC
November 2019

Comparison of the performance of a chemiluminescence assay and an ELISA for detection of anti-GBM antibodies.

Ren Fail 2020 Nov;42(1):48-53

Renal Division, Department of Medicine, Peking University First Hospital, Beijing, PR. China.

Autoantibodies to the α3 chain noncollagen 1 domain of type IV collagen (α3(IV)NC1) are a serological hallmark in the diagnosis of anti-glomerular basement membrane (GBM) disease. The objective of our study was to compare the performance of anti-glomerular basement membrane (GBM) antibody detection by chemiluminescence immunoassay (CIA) and by enzyme-linked immunosorbent assays (ELISAs). Sera from outpatients who were suspected to have anti-GBM disease and 31 patients with biopsy-proven anti-GBM disease were collected. Read More

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http://dx.doi.org/10.1080/0886022X.2019.1702056DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6968565PMC
November 2020

Therapeutic Myeloperoxidase Inhibition Attenuates Neutrophil Activation, ANCA-Mediated Endothelial Damage, and Crescentic GN.

J Am Soc Nephrol 2020 Feb 26;31(2):350-364. Epub 2019 Dec 26.

Centre for Nephrology and

Background: Myeloperoxidase released after neutrophil and monocyte activation can generate reactive oxygen species, leading to host tissue damage. Extracellular glomerular myeloperoxidase deposition, seen in ANCA-associated vasculitis, may enhance crescentic GN through antigen-specific T and B cell activation. Myeloperoxidase-deficient animals have attenuated GN early on, but augmented T cell responses. Read More

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http://dx.doi.org/10.1681/ASN.2019060618DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7003306PMC
February 2020

Concurrent treatment with rituximab and plasma exchange for severe refractory granulomatosis with polyangiitis: A case report.

Medicine (Baltimore) 2019 Dec;98(51):e18139

Department of Rheumatology, School of Medicine, Kyung Hee University, Seoul, South Korea.

Rationale: Rituximab is recommended to induce remission of severe granulomatosis with polyangiitis (GPA). Plasma exchange (PE) may be considered in the setting of rapidly progressive glomerulonephritis (RPGN) with a serum creatinine increase of more than 5.6 mg/dl or diffuse alveolar hemorrhage (DAH). Read More

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http://dx.doi.org/10.1097/MD.0000000000018139DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6940185PMC
December 2019

Monoclonal immunoglobulin G1 κ-type atypical antiglomerular basement membrane disease accompanied by necrotizing glomerulonephritis
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Clin Nephrol 2020 Mar;93(3):152-157

Introduction: Patients without detectable serum antiglomerular basement membrane (GBM) antibodies but with GBM staining for immunoglobulins (Ig), absence of a crescentic phenotype, mild renal insufficiency, and absence of pulmonary hemorrhage have atypical anti-GBM diseases. We report the case of a 64-year-old man with slowly progressive glomerulonephritis.

Case History: A 64-year-old Peruvian man presented with persistent microscopic hematuria, proteinuria of 2. Read More

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http://dx.doi.org/10.5414/CN109889DOI Listing

Crescentic poststreptococcal acute glomerulonephritis accompanied by small vessel vasculitis: case report of an elderly male.

BMC Nephrol 2019 12 18;20(1):471. Epub 2019 Dec 18.

Department of Nephrology and Dialysis, Kitano Hospital, Tazuke Kofukai Medical Research Institute, 2-4-20 Ohgimachi, Kita-ku, Osaka, 530-8480, Japan.

Background: Poststreptococcal acute glomerulonephritis (PSAGN) in the elderly tends to have a severe clinical course and often presents with crescentic necrotizing glomerulonephritis in the renal biopsy. However, vasculitis lesions are unusual.

Case Presentation: We present a 71-year-old man who was admitted to our hospital for a recurrent gout attack with a rapid decline of renal function. Read More

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http://dx.doi.org/10.1186/s12882-019-1663-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6921464PMC
December 2019

Association between neutrophil-lymphocyte & platelet lymphocyte ratios with prognosis & mortality in rapidly progressive glomerulonephritis.

Indian J Med Res 2019 10;150(4):399-406

Division of Nephrology, Department of Medicine, University of Celal Bayar, Manisa, Turkey.

Background & Objectives: Rapidly progressive glomerulonephritis (RPGN) is a clinical syndrome manifested by features of nephritic syndrome and progressive loss of renal function over a short time. The objective of this study was to investigate the relationship between neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR) and prognostic factors and pathological findings of renal biopsy in RPGN.

Methods: Consecutive newly diagnosed RPGN patients who had follow up for at least six months were retrospectively analyzed. Read More

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http://dx.doi.org/10.4103/ijmr.IJMR_1234_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6902366PMC
October 2019

Resolution of syphilis-related rapidly progressive glomerulonephritis with penicillin therapy: Case report
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Clin Nephrol 2020 Feb;93(2):106-110

Renal manifestations of syphilis are variable, with membranous nephropathy being the most commonly described lesion. Rapidly progressive glomerulonephritis (RPGN) is rare and there is only one case report in the literature describing syphilis-associated crescentic glomerulonephritis. We report a rare case of RPGN secondary to latent syphilis, which resolved with penicillin treatment in the absence of immunosuppressive therapy. Read More

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http://dx.doi.org/10.5414/CN109847DOI Listing
February 2020

An overlap of antineutrophil cytoplasmic antibody (ANCA)-associated glomerulonephritis and IgG4-related kidney disease.

Clin Chim Acta 2020 Feb 2;501:12-19. Epub 2019 Dec 2.

Renal Division, Department of Medicine, Peking University First Hospital, Peking University Institute of Nephrology, Key Laboratory of Renal Disease, Ministry of Health of China, Key Laboratory of Chronic Kidney Disease Prevention and Treatment (Peking University), Ministry of Education, Beijing 100034, China; Peking-Tsinghua Center for Life Sciences, Beijing 100034, China.

Background: We investigated the characteristics of antineutrophil cytoplasmic antibody (ANCA)-associated glomerulonephritis (ANCA-GN) and immunoglobulin G4 (IgG4)-related kidney disease (IgG4-RKD) overlap syndrome.

Methods: This is a 2-center study with 19 patients.

Results: Fifteen patients were classified as microscopic polyangiitis (MPA). Read More

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http://dx.doi.org/10.1016/j.cca.2019.11.030DOI Listing
February 2020

endocarditis masquerading as systemic vasculitis with rapidly progressive glomerulonephritis (aka 'Löhlein nephritis').

BMJ Case Rep 2019 Dec 3;12(12). Epub 2019 Dec 3.

Internal Medicine H, Tel Aviv Ichilov-Sourasky Medical Center, Tel Aviv, Israel.

species are fastidious, Gram-negative aerobic rods and a well-recognised pathogen responsible for culture-negative endocarditis. The histopathological appearance of glomerulonephritis (GN) caused by endocarditis may include a pauci-immune GN similar to that usually seen in antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis. Herein, we present an unusual case report of endocarditis masquerading as ANCA-positive vasculitis, with crescentic GN. Read More

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http://dx.doi.org/10.1136/bcr-2019-231413DOI Listing
December 2019

Proteinase 3-antineutrophil cytoplasmic antibody-positive necrotizing crescentic glomerulonephritis complicated by infectious endocarditis: a case report.

J Med Case Rep 2019 Dec 5;13(1):356. Epub 2019 Dec 5.

Division of Nephrology, First Department of Integrated Medicine, Saitama Medical Center, Jichi Medical University, 1-847 Amanuma-cho, Omiya-ku, Saitama, Saitama, 330-8503, Japan.

Background: Proteinase 3-antineutrophil cytoplasmic antibody has been reported to be positive in 5-10% of cases of renal injury complicated by infective endocarditis; however, histological findings have rarely been reported for these cases.

Case Presentation: A 71-year-old Japanese man with a history of aortic valve replacement developed rapidly progressive renal dysfunction with gross hematuria and proteinuria. Blood analysis showed a high proteinase 3-antineutrophil cytoplasmic antibody (163 IU/ml) titer. Read More

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http://dx.doi.org/10.1186/s13256-019-2287-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6894315PMC
December 2019

Etiopathological Study of Crescentic Glomerulonephritis and its Outcome: A Retrospective Analysis.

J Assoc Physicians India 2019 Nov;67(11):18-21

Professor of Pathology, Department of Nephrology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh.

Introduction: Crescentic Glomerulonephritis (CGN) is most aggressive structural phenotype and accounts for 2%-7% of renal biopsy in most series. The aim of study was to assess the clinical feature and outcome of CGN at our centre.

Material And Methods: The renal biopsy performed during the period of January 2015 to January 2018 was studied and patients showing crescentic glomerulonephritis on histology were selected for this study. Read More

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November 2019

Complement alternative pathway in ANCA-associated vasculitis: Two decades from bench to bedside.

Autoimmun Rev 2020 Jan 15;19(1):102424. Epub 2019 Nov 15.

Service de Néphrologie-Dialyse-Transplantation, Université d'Angers, CHU Angers, Angers, France; CRCINA, INSERM, Université de Nantes, Université d'Angers, Angers, France. Electronic address:

Anti-neutrophil cytoplasmic autoantibodies (ANCA)-associated vasculitides (AAVs) are small vessel vasculitides involving predominantly ear-nose-throat, kidneys, lungs and nerves. AAVs are life-threatening diseases, especially in their most severe forms such as necrotizing crescentic glomerulonephritis (GN) and/or intra-alveolar hemorrhage. Unlike immune complex GN or anti-glomerular basement membrane GN, AAVs are classified as pauci-immune GN. Read More

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http://dx.doi.org/10.1016/j.autrev.2019.102424DOI Listing
January 2020

Serum uromodulin is associated with the severity of clinicopathological findings in ANCA-associated glomerulonephritis.

PLoS One 2019 14;14(11):e0224690. Epub 2019 Nov 14.

Division of Nephrology, Department of Medicine, Showa University School of Medicine, Tokyo, Japan.

Background: Uromodulin (UMOD), also known as Tamm-Horsfall protein, is a kidney-specific protein expressed by epithelial cells lining the thick ascending limb of the loop of Henle. In the current study, we aimed to clarify the clinical significance of UMOD in ANCA-associated glomerulonephritis (AAG).

Materials And Methods: Sixty-one biopsy-proven AAG patients were included in this study. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0224690PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6855443PMC

A unique presentation of a rare disease: biopsy proven systemic lupus erythematosus and microscopic polyangitis: an overlap syndrome.

J Community Hosp Intern Med Perspect 2019 1;9(5):433-436. Epub 2019 Nov 1.

Department of Internal Medicine, Long Island Community Hospital, Patchogue, NY, USA.

Systemic Lupus Erythematosus (SLE) and ANCA-associated vasculitis are classically thought to be separate diseases with different pathophysiologies. An overlap of these diseases has been reported few times in the literature. We present a unique case of a Caucasian male in his third decade of life, without a previous personal or family history of autoimmune disease, with serological and biopsy findings of both diseases occurring simultaneously. Read More

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http://dx.doi.org/10.1080/20009666.2019.1659659DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6830228PMC
November 2019

Pauci-immune Crescentic Glomerulonephritis Due to MGRS Crystalline Nephropathy.

Kidney Int Rep 2019 Oct 27;4(10):1503-1507. Epub 2019 Jul 27.

Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.

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http://dx.doi.org/10.1016/j.ekir.2019.07.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6829195PMC
October 2019