2,331 results match your criteria Glomerulonephritis Crescentic


Clinical Implications of Excessive Neutrophil Extracellular Trap Formation in Renal Autoimmune Diseases.

Kidney Int Rep 2019 Feb 19;4(2):196-211. Epub 2018 Nov 19.

Department of Nephrology, Leiden University Medical Centre, Leiden, The Netherlands.

Neutrophil extracellular traps (NETs) are extracellular DNA structures covered with antimicrobial peptides, danger molecules, and autoantigens that can be released by neutrophils. NETs are an important first-line defense mechanism against bacterial, viral, fungal, and parasitic infections, but they can also play a role in autoimmune diseases. NETs are immunogenic and toxic structures that are recognized by the autoantibodies of patients with antineutrophil cytoplasmic antibodies-associated vasculitis (AAV) (i. Read More

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http://dx.doi.org/10.1016/j.ekir.2018.11.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365354PMC
February 2019

The co-inhibitory molecule PD-L1 contributes to regulatory T cell-mediated protection in murine crescentic glomerulonephritis.

Sci Rep 2019 Feb 14;9(1):2038. Epub 2019 Feb 14.

Institute of Experimental Immunology and Hepatology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Immune-mediated glomerular diseases like crescentic glomerulonephritis (cGN) are driven by inappropriately regulated cellular and humoral immune responses subsequently leading to renal tissue injury. Recent studies demonstrated the crucial role for regulatory T cells (Tregs) in suppressing pathogenic T-cell responses during nephrotoxic nephritis (NTN), a murine model of cGN. However, mechanisms of immune regulation in cGN are less clear. Read More

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http://dx.doi.org/10.1038/s41598-018-38432-3DOI Listing
February 2019

Dual anti-neutrophil cytoplasmic antibody and anti-glomerular basement membrane antibody-positive crescent glomerulonephritis in a patient with monoclonal gammopathy of undetermined significance: A case report.

Medicine (Baltimore) 2019 Feb;98(7):e14557

Department of Nephrology.

Rationale: Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) and anti-glomerular basement membrane (GBM) antibody disease are both rare autoimmune diseases. Monoclonal gammopathy of undetermined significance (MGUS) is one of the most common causes of plasma cell dyscrasias (PCD). The three entities can cause renal lesions via different mechanisms and, however, they have not been reported in a single patient with renal lesion. Read More

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http://dx.doi.org/10.1097/MD.0000000000014557DOI Listing
February 2019

Distinction between MPO-ANCA and PR3-ANCA-associated glomerulonephritis in Chinese patients: a retrospective single-center study.

Clin Rheumatol 2019 Feb 8. Epub 2019 Feb 8.

Jinling Clinical Medical College of Nanjing Medical University, Nanjing, China.

Objectives: To retrospectively investigate the clinical and histological features and outcomes of ANCA-associated glomerulonephritis (AAGN) with different ANCA serotypes.

Method: A total of 467 AAGN patients were divided into MPO-AAGN (MPO) and PR3-AAGN (PR3) groups according to ANCA serotype. Clinical and histological features and renal outcomes were compared. Read More

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http://dx.doi.org/10.1007/s10067-019-04458-9DOI Listing
February 2019
1 Read

Endogenous IL-22 is dispensable for experimental glomerulonephritis.

Am J Physiol Renal Physiol 2019 Feb 6. Epub 2019 Feb 6.

III. Medizinische Klinik und Poliklinik, Universitaetsklinikum Hamburg-Eppendorf, Germany.

In recent years, the cytokine IL-22 attracted considerable attention due to its important immunoregulatory function in barrier tissues, such as the gut, lung and skin. While a regenerative role of IL-22 in renal tubular damage has been demonstrated, the role of IL-22 in the immunopathogenesis of glomerular injury is still unknown. Here, we demonstrate that the IL-22 receptor is expressed in the glomerular compartment of the kidney and that IL-22 expression increases in the renal cortex after induction of glomerular injury in a mouse model for crescentic glomerulonephritis (cGN, nephrotoxic nephritis). Read More

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http://dx.doi.org/10.1152/ajprenal.00303.2018DOI Listing
February 2019
2 Reads

A case of aggressive atypical anti-GBM disease complicated by CMV pneumonitis.

BMC Nephrol 2019 Jan 31;20(1):29. Epub 2019 Jan 31.

Department of Pathology and Laboratory Medicine, Cumming School of Medicine, University of Calgary, Foothills Medical Center, 1403 29 St NW, Calgary, AB, T2N 2T9, Canada.

Background: Anti-glomerular basement membrane (anti-GBM) disease is characterized by circulating IgG glomerular basement membrane antibodies and is clinically expressed as a rapidly progressive crescentic glomerulonephritis (GN), with 30-60% of patients also developing pulmonary hemorrhage. Classically, the renal biopsy shows glomerular crescent formation, bright linear staining of glomerular basement membranes (GBM) for IgG on direct immunofluorescence (IF), and the serologic presence of circulating anti-GBM antibodies. Recently, patients with linear IgG IF staining, undetectable circulating anti-GBM antibodies and glomerular changes atypical for anti-GBM disease have been described as "atypical anti-GBM disease", with a distinctly more benign clinical course than typical anti-GBM disease. Read More

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http://dx.doi.org/10.1186/s12882-019-1227-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357502PMC
January 2019
2 Reads

Development of anti-glomerular basement membrane glomerulonephritis during the course of IgA nephropathy: a case report.

BMC Nephrol 2019 Jan 25;20(1):25. Epub 2019 Jan 25.

Department of Nephrology and Blood Purification, Kidney Disease Center, Tokyo Medical University Hachioji Medical Center, 1163 Tatemachi, Hachioji, Tokyo, 193-0998, Japan.

Background: Anti-glomerular basement membrane (GBM) glomerulonephritis does not usually coexist with another glomerulonephritis such as IgA nephropathy. We present a rare case having a combination of these two diseases, and furthermore, histological evaluation could be performed before and after the development of anti-GBM glomerulonephritis over a period of only10 months.

Case Presentation: A 66-year-old woman was admitted with complaints of microscopic hematuria and mild proteinuria for the past 3 years. Read More

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http://dx.doi.org/10.1186/s12882-019-1207-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347754PMC
January 2019
2 Reads

Infliximab-associated focal segmental glomerulosclerosis in a patient with ankylosing spondylitis.

Rheumatol Int 2019 Mar 23;39(3):561-567. Epub 2019 Jan 23.

Division of Rheumatology, Department of Internal Medicine, Dokuz Eylul University School of Medicine, Izmir, Turkey.

The introduction of tumor necrosis factor-alpha (TNF-α)-targeting drugs has given new opportunities in the treatment of various inflammatory rheumatic diseases and has been the most important development in the treatment of spondyloarthritis (SpA). However, the increasing use and longer follow-up periods of treatment also pose risks of developing various adverse effects ranging from common ones including infections to uncommon renal complications. This report describes a case of infliximab-induced focal segmental glomerulosclerosis (FSGS) in a 40-year-old female patient with ankylosing spondylitis (AS) who presented with asymptomatic proteinuria and microscopic hematuria. Read More

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http://link.springer.com/10.1007/s00296-019-04241-8
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http://dx.doi.org/10.1007/s00296-019-04241-8DOI Listing
March 2019
5 Reads

TRPC6 inactivation does not affect loss of renal function in nephrotoxic serum glomerulonephritis in rats, but reduces severity of glomerular lesions.

Biochem Biophys Rep 2019 Mar 8;17:139-150. Epub 2019 Jan 8.

Department of Biology and Biochemistry, University of Houston, Houston, TX, USA.

Canonical transient receptor potential-6 (TRPC6) channels have been implicated in a variety of chronic kidney diseases including familial and acquired forms of focal and segmental glomerulosclerosis (FSGS) and renal fibrosis following ureteral obstruction. Here we have examined the role of TRPC6 in progression of inflammation and fibrosis in the nephrotoxic serum (NTS) model of crescentic glomerulonephritis. This was assessed in rats with non-functional TRPC6 channels due to genomic disruption of an essential domain in TRPC6 channels ( rats) and wild-type littermates ( rats). Read More

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http://dx.doi.org/10.1016/j.bbrep.2018.12.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6325086PMC
March 2019
1 Read

The role of regulatory T cells in Experimental Autoimmune Glomerulonephritis.

Am J Physiol Renal Physiol 2019 Jan 16. Epub 2019 Jan 16.

Institute of Immunology, University Medical Center Hamburg-Eppendorf, Germany.

Anti-glomerular basement membrane (anti-GBM) disease is characterized by antibodies and T cells directed against the Goodpasture antigen α3(IV)NC1 of the GBM. Consequences are the deposition of autoantibodies along the GBM and the development of crescentic glomerulonephritis (GN) with rapid loss of renal function. Foxp3 regulatory T cells (Treg cells) are crucial for the maintenance of peripheral tolerance to self-antigens and the prevention of immunopathology. Read More

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http://dx.doi.org/10.1152/ajprenal.00558.2018DOI Listing
January 2019
2 Reads

Clinical outcomes in patients with biopsy-proved diabetic nephropathy compared to isolated lupus or crescentic glomerulonephritis.

Diabetes Res Clin Pract 2019 Jan 11;148:144-151. Epub 2019 Jan 11.

Renal Division, Department of Internal Medicine, National Taiwan University Hospital, College of Medicine, National Taiwan University, No. 7, Chung Shan S. Rd., Zhongzheng Dist., Taipei City 10002, Taiwan. Electronic address:

Aims: Diabetic nephropathy (DMN) is usually diagnosed clinically without pathology, and the prognosis of which compared to non-diabetic renal diseases has rarely been investigated especially in ethnic Chinese population. Here we reported the outcome of patients with biopsy-proved DMN compared to those with isolated crescentic glomerulonephritis (GN) or lupus nephritis (LN).

Methods: This retrospective observational study included patients with DMN (n = 55), crescentic GN (n = 48) and LN (n = 82) from an original cohort of 987 adult patients who underwent kidney biopsy. Read More

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http://dx.doi.org/10.1016/j.diabres.2019.01.014DOI Listing
January 2019
4 Reads

Cerebral venous sinus thrombosis as a warning signal for double positive crescentic glomerulonephritis in a young male with complete renal recovery.

Saudi J Kidney Dis Transpl 2018 Nov-Dec;29(6):1488-1493

Department of Renal Pathology, Lal Path Lab, New Delhi, India.

Double positive crescentic glomerulonephritis is relatively rare in young population and has variable outcomes. Although increased incidence of deep venous thrombosis in antineutrophil cytoplasmic antibody-associated vasculitis has been reported, cerebral venous sinus thrombosis (CVT) is very rare. We present a young male who presented with CVT followed by rapidly progressive crescentic glomerulonephritis and with appropriate therapeutic modalities he had complete renal and partial neurological recovery. Read More

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http://dx.doi.org/10.4103/1319-2442.248291DOI Listing
December 2018
126 Reads

ANCA-Associated Necrotizing Glomerulonephritis Overlapping with Mesangial Proliferative Lupus Nephritis Refractory to Plasmapheresis, Steroid Pulse Therapy, and a Combination of Mycophenolate Mofetil and Rituximab.

Case Rep Rheumatol 2018 19;2018:3076806. Epub 2018 Nov 19.

Division of Rheumatology, SUNY Upstate Medical University, Syracuse, NY 13210, USA.

Necrotizing glomerulonephritis (GN) associated with antineutrophil cytoplasmic antibody (ANCA) has been increasingly recognized in the context of class III or IV lupus nephritis (LN), hereafter designated as . While this subset of GN appears to portend an unfavorable renal outcome, it is not clear whether it represents a distinct entity and benefits from a more aggressive therapy. We report a 78-year-old woman who presented with rapidly progressive GN and was found to have a double-stranded DNA (dsDNA) antibody, hypocomplementemia, antiphospholipid antibody, and strongly positive myeloperoxidase antibody. Read More

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http://dx.doi.org/10.1155/2018/3076806DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276453PMC
November 2018
1 Read

A Case of Self-Limiting Crescentic Immunoglobulin A Glomerulonephritis Associated with Sternoclavicular Arthritis.

Case Rep Nephrol Dial 2018 Sep-Dec;8(3):246-252. Epub 2018 Nov 21.

Division of Nephrology and Hypertension, Department of Internal Medicine, St. Marianna University School of Medicine, Kanagawa, Japan.

Immunoglobulin (Ig) A glomerulonephritis (GN) is a heterogeneous disease affected by various factors. Genetic and other factors "hit" DNA, causing IgA malformation and ultimately glomerular injury. We describe a rare case of crescentic IgA GN with sternoclavicular (SC) arthritis in a 75-year-old woman. Read More

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https://www.karger.com/Article/FullText/494715
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http://dx.doi.org/10.1159/000494715DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276760PMC
November 2018
8 Reads

A rare case of Alport syndrome, atypical hemolytic uremic syndrome and Pauci-immune crescentic glomerulonephritis.

BMC Nephrol 2018 Dec 12;19(1):355. Epub 2018 Dec 12.

Department of Pathology, Stanford University, Stanford, CA, USA.

Background: Renal thrombotic microangiopathy (TMA) is occasionally seen in biopsies with pauci-immune necrotizing crescentic glomerulonephritis (PCGN). Recent study indicated that the complement activation is more prominent in the ANCA-negative glomerulonephritis.

Case Presentation: We report a case of concurrent TMA and PCGN without ANCA positivity. Read More

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http://dx.doi.org/10.1186/s12882-018-1170-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6291978PMC
December 2018

Activation of fibroblastic reticular cells in kidney lymph node during crescentic glomerulonephritis.

Kidney Int 2019 Feb 3;95(2):310-320. Epub 2018 Dec 3.

Transplantation Research Center, Brigham and Women's Hospital, Boston, Massachusetts, USA; Division of Renal Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA. Electronic address:

Crescentic glomerulonephritis is an inflammatory condition characterized by rapid deterioration of kidney function. Previous studies of crescentic glomerulonephritis have focused on immune activation in the kidney. However, the role of fibroblastic reticular cells, which reside in the stromal compartment of the kidney lymph node, has not been studied in this condition. Read More

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http://dx.doi.org/10.1016/j.kint.2018.08.040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6342621PMC
February 2019
2 Reads

Elevated Levels of Urinary Extracellular Vesicle Fibroblast-Specific Protein 1 in Patients with Active Crescentic Glomerulonephritis.

Nephron 2018 Dec 12:1-11. Epub 2018 Dec 12.

Department of Nephrology, Faculty of Medical Sciences, University of Fukui, Fukui, Japan.

Background/aims: Extracellular vesicles (EVs), including exosomes, are present in various bodily fluids, including urine. We and others previously reported that cells expressing fibroblast-specific protein 1 (FSP1) accumulate within damaged glomeruli, and that urinary FSP1, as well as urinary soluble CD163, could potentially serve as a biomarker of ongoing glomerular injury.

Methods: To test that idea, we collected urine samples from 37 patients with glomerular disease; purified the urinary EVs; characterized them using Nanosight, western blotting, and immunoelectron microscopy; and determined FSP1 and soluble CD163 levels using enzyme-linked immunosorbent assays. Read More

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http://dx.doi.org/10.1159/000495217DOI Listing
December 2018
7 Reads

Mechanisms and functions of IL-17 signaling in renal autoimmune diseases.

Mol Immunol 2018 Dec 15;104:90-99. Epub 2018 Nov 15.

III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Section of Translational Immunology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. Electronic address:

Immune-mediated glomerular diseases (glomerulonephritis) encompass a heterogeneous collection of diseases that cause inflammation within the glomerulus and other renal compartments with significant morbidity and mortality. In general, CD4 T cells orchestrate the immune response and play a unique role in autoimmune and chronic inflammatory diseases. In particular, the characterization of a distinct, IL-17 cytokines producing CD4 T cell subset named T17 cells has significantly advanced the current understanding of the pathogenic mechanisms of organ-specific immunity. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01615890183076
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http://dx.doi.org/10.1016/j.molimm.2018.09.005DOI Listing
December 2018
9 Reads

A case report of granulomatous polyangiitis complicated by tuberculous lymphadenitis.

Medicine (Baltimore) 2018 Oct;97(43):e12430

Lung Cancer and Respiratory Disease Center, Yamanashi Central Hospital.

Rational: Granulomatous polyangiitis (GPA) is a type of vasculitis involving medium and small arteries, typically affecting the upper and lower respiratory tract with coexisting glomerulonephritis. GPA is also characterized by necrotizing granulomatous inflammation and the presence of antineutrophil cytoplasm antibodies (ANCA). So far, various infections have lead to elevation of titers of serum ANCA, making it difficult to diagnose. Read More

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http://Insights.ovid.com/crossref?an=00005792-201810260-0000
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http://dx.doi.org/10.1097/MD.0000000000012430DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6221664PMC
October 2018
12 Reads

Prognostic Factors for Survival and Relapse in ANCA-Associated Vasculitis with Renal Involvement: A Clinical Long-Term Follow-Up Study.

Int J Nephrol 2018 16;2018:6369814. Epub 2018 Oct 16.

Abdomen Center, Nephrology, Helsinki University Hospital, Helsinki, Finland.

Aim: We describe the clinical pattern of ANCA-associated vasculitis (AAV) and assess long-term prognostic factors of patients and renal survival and relapse.

Methods: Data from 85 patients with renal biopsy-proven AAV at a single center with up to 20-year [median 16.2 years (95% CI 14. Read More

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https://www.hindawi.com/journals/ijn/2018/6369814/
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http://dx.doi.org/10.1155/2018/6369814DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6206576PMC
October 2018
26 Reads

Antiglomerular Basement Membrane Disease.

Semin Respir Crit Care Med 2018 08 7;39(4):494-503. Epub 2018 Nov 7.

Department of Medicine, Centre for Inflammatory Disease, Imperial College London, London, United Kingdom.

Antiglomerular basement membrane (anti-GBM) disease is a rare but life-threatening autoimmune vasculitis that is characterized by the development of pathogenic autoantibodies to type IV collagen antigens expressed in the glomerular and alveolar basement membranes. Once deposited in tissue, these autoantibodies incite a local capillaritis which manifests as rapidly progressive glomerulonephritis (GN) in 80 to 90% of patients, and with concurrent alveolar hemorrhage in ∼50%. A small proportion of cases may present with pulmonary disease in isolation. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/s-0038-1669413
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http://dx.doi.org/10.1055/s-0038-1669413DOI Listing
August 2018
10 Reads

Microscopic Polyangiitis: New Insights into Pathogenesis, Clinical Features and Therapy.

Authors:
Alexandre Karras

Semin Respir Crit Care Med 2018 08 7;39(4):459-464. Epub 2018 Nov 7.

Department of Nephrology, Hôpital Européen Georges Pompidou, Assistance Publique- Hôpitaux de Paris, Paris France.

Microscopic polyangiitis (MPA) is one of the main clinical presentations of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitides. Although the disease is defined by clinical and pathological criteria, the anti-myeloperoxidase (MPO) specificity of ANCAs is observed in almost 80% of MPA patients. The direct pathogenic role of anti-MPO antibodies has been proven in animal models, in which the disease was transmitted by transfer of anti-MPO antibodies or anti-MPO-specific splenocytes. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/s-0038-1673387
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http://dx.doi.org/10.1055/s-0038-1673387DOI Listing
August 2018
7 Reads

Bacterial endocarditis manifesting as autoimmune pulmonary renal syndrome: ANCA-associated lung hemorrhage and pauci-immune crescentic glomerulonephritis
.

Clin Nephrol 2018 Dec;90(6):431-433

The etiology of pulmonary renal syndrome can be broadly divided into infectious and autoimmune (predominantly ANCA vasculitis). The importance of timely differentiating between them stems from the deleterious effects of their respective treatment if misdiagnosed. Serology and tissue evaluation by pathology are employed to aid in this, however, in rare cases, this can be difficult. Read More

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http://dx.doi.org/10.5414/CN109495DOI Listing
December 2018
14 Reads

Patterns of renal involvement in a cohort of patients with inflammatory bowel disease in Egypt.

Acta Gastroenterol Belg 2018 Jul-Sep;81(3):381-385

Department of Medicine, Cairo University Hospital, Cairo, Egypt.

Background And Study Aim: Renal complications are frequent extraintestinal manifestations in inflammatory bowel disease (IBD). We aimed in our study to describe the spectrum of renal affection in our IBD patients.

Patients And Methods: This study is a retrospective analysis of renal biopsies done for IBD patients who developed renal diseases, at Cairo University Hospital, from June 2005 to Jan. Read More

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October 2018
9 Reads

Role of Steroids in Post-streptococcal Glomerulonephritis Without Crescents on Renal Biopsy.

Cureus 2018 Aug 15;10(8):e3150. Epub 2018 Aug 15.

Nephrology, Guthrie Clinic/Robert Packer Hospital, Sayre, USA.

Steroid is usually indicated in patients with post-streptococcal glomerulonephritis (PSGN) with more than 30% crescents on renal biopsy. The role of steroids in patients without crescentic glomerulonephritis is not clear. We present a 19-year-old male patient who was diagnosed with PSGN three weeks after a sore throat infection. Read More

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https://www.cureus.com/articles/14052-role-of-steroids-in-po
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http://dx.doi.org/10.7759/cureus.3150DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6191008PMC
August 2018
8 Reads

Histopathological Classification-A Prognostic Tool for Rapidly Progressive Glomerulonephritis.

Medicina (Kaunas) 2018 Apr 17;54(2). Epub 2018 Apr 17.

Centre of Nephrology, Vilnius University Hospital Santaros Klinikos, LT⁻08661 Vilnius, Lithuania.

Recently proposed histopathological classification may predict patient outcome in pauci-immune glomerulonephritis. This study sought to prove that the prognostic effect could be extended to all types of rapidly progressive glomerulonephritis. Retrospective analysis of patients diagnosed with rapidly progressive glomerulonephritis between April 1999 and August 2015 was performed. Read More

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http://www.mdpi.com/1648-9144/54/2/17
Publisher Site
http://dx.doi.org/10.3390/medicina54020017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6037248PMC
April 2018
9 Reads

Fibrillary Glomerulonephritis with Crescentic and Necrotizing Glomerulonephritis and Concurrent Thrombotic Microangiopathy.

Case Rep Nephrol Dial 2018 May-Aug;8(2):182-191. Epub 2018 Aug 31.

Regina General Hospital, Section of Nephrology, Department of Medicine, Regina, Saskatchewan, Canada.

We present a 77-year-old Caucasian woman who presented with nephrotic-range proteinuria, microhematuria, renal impairment, and extremely elevated blood pressure. She had a long history of well-controlled type 2 diabetes. Renal biopsy revealed fibrillary deposits in the mesangium and glomerular basement membrane consistent with fibrillary glomerulopathy (FGN), with crescentic changes and thrombotic microangiopathy (TMA). Read More

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http://dx.doi.org/10.1159/000492529DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6167697PMC
August 2018
9 Reads

Clinicopathological features and outcome of antibody-negative anti-glomerular basement membrane disease.

J Clin Pathol 2019 Jan 12;72(1):31-37. Epub 2018 Oct 12.

National Clinical Research Center of Kidney Diseases, Jinling Hospital, Nanjing University School of Medicine, Nanjing, China

Aim: To explore the clinicopathological characteristics of patients with anti-GBM antibody-negative anti-GBM disease.

Methods: The clinical and renal pathological findings were retrospectively studied in 19 patients. All patients met the following inclusion criteria: linear GBM IgG deposition on immunofluorescence(IF); and lack of serum anti-GBM antibodies by ELISA and indirect immunofluorescence assay. Read More

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http://jcp.bmj.com/lookup/doi/10.1136/jclinpath-2018-205278
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http://dx.doi.org/10.1136/jclinpath-2018-205278DOI Listing
January 2019
13 Reads
2.920 Impact Factor

Histopathological classification of anti-neutrophil cytoplasmic antibody-associated glomerulonephritis in a nationwide Japanese prospective 2-year follow-up cohort study.

Clin Exp Nephrol 2018 Oct 10. Epub 2018 Oct 10.

Department of Nephrology, Internal Medicine, Nagoya University Graduate School of Medicine, Aichi, Japan.

Background: The prognostic value of the EUVAS-proposed histopathological classification of anti-neutrophil cytoplasmic antibody (ANCA)-associated glomerulonephritis has been evaluated throughout the world. Here, we performed a Japanese nationwide biopsy survey to assess the association between this histopathological classification and renal prognosis after 2-year follow-up in ANCA-associated glomerulonephritis.

Methods: We collected 67 renal biopsy materials of the 321 entries in the RemIT-JAV-RPGN cohort study, and assessed their histologies. Read More

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http://dx.doi.org/10.1007/s10157-018-1656-1DOI Listing
October 2018
3 Reads

Clinical and pathologic characteristics of pauci-immune anti-myeloperoxidase antibody associated glomerulonephritis with nephrotic range proteinuria.

Ren Fail 2018 Nov;40(1):554-560

a Department of Nephrology , Tianjin Medical University General Hospital , Tianjin , China.

Background: Heavy proteinuria in antineutrophil cytoplasmic antibody (ANCA)-associated glomerulonephritis (GN) is usually considered to be associated with immune deposits in renal biopsy. Nephrotic ANCA GN without immune deposits (pauci-immune) is rare and has not been studied specially. In this study characteristics of these patients are to be investigated. Read More

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http://dx.doi.org/10.1080/0886022X.2018.1487865DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6171425PMC
November 2018
4 Reads
0.780 Impact Factor

Renal Involvement in Antineutrophil Cytoplasmic Antibody-Associated Vasculitis.

Rheum Dis Clin North Am 2018 11 7;44(4):525-543. Epub 2018 Sep 7.

Division of Nephrology, Vasculitis and Glomerulonephritis Center, Massachusetts General Hospital, 101 Merrimac Street, Boston, MA 02114, USA. Electronic address:

Antineutrophil cytoplasmic antibody-associated vasculitis (AAV) is the most common cause of rapidly progressive glomerulonephritis. ANCAs play an important role in the pathogenesis and diagnosis of AAV. The classic renal lesion in AAV is a pauci-immune necrotizing and crescentic glomerulonephritis. Read More

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http://dx.doi.org/10.1016/j.rdc.2018.06.001DOI Listing
November 2018
13 Reads

Unusual case of levamisole-induced dual-positive ANCA vasculitis and crescentic glomerulonephritis.

BMJ Case Rep 2018 Sep 19;2018. Epub 2018 Sep 19.

Department of Medicine, Jacobi Medical Center, Bronx, New York, USA.

Cocaine adulterated levamisole is an increasingly reported cause of skin necrosis, arthralgia and systemic vasculitis, but renal involvement is uncommon. We present a case of a 40-year-old Hispanic man with a history of cocaine abuse who presented with acute kidney injury to the rheumatology clinic where he was being treated for chronic inflammatory arthritis. He was found to have a serum creatinine of 2. Read More

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http://dx.doi.org/10.1136/bcr-2018-225913DOI Listing
September 2018
7 Reads

Methimazole-Induced Pauci-Immune Glomerulonephritis and Anti-Phospholipid Syndrome: An Important Association to Be Aware of.

J Clin Med Res 2018 Oct 10;10(10):786-790. Epub 2018 Sep 10.

Department of Medicine, Jersey Shore University Medical Center, Hackensack Meridian Health, Neptune, NJ 07753, USA.

While methimazole (MMI) is the first line treatment for hyperthyroidism, this medication is not devoid of adverse effects. In this article, we present a 70-year-old male who admitted the hospital with right lower extremity pain and rash. The patient was recently treated with MMI for hyperthyroidism. Read More

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http://dx.doi.org/10.14740/jocmr3530wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6135002PMC
October 2018
3 Reads

Endocarditis Mimicking Crescentic Glomerulonephritis with PR3-ANCA Positivity.

Case Rep Nephrol 2018 19;2018:9607582. Epub 2018 Aug 19.

Department of Internal Medicine, Oakland University William Beaumont School of Medicine, Royal Oak, MI, USA.

is a fastidious organism that causes cat scratch disease, commonly associated with fever and lymphadenopathy but, in rare instances, also results in culture-negative infectious endocarditis. We describe a patient who presented with flank pain, splenic infarct, and acute kidney injury with an active urinary sediment, initially suspicious for vasculitis, which was subsequently diagnosed as endocarditis. endocarditis may present with a crescentic glomerulonephritis (GN) and elevated PR3-ANCA antibody titers, mimicking ANCA-associated GN, with 54 cases reported in the literature. Read More

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http://dx.doi.org/10.1155/2018/9607582DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6120290PMC
August 2018
3 Reads

Crescentic glomerulonephritis with anti-GBM antibody but no glomerular deposition.

BMC Nephrol 2018 Sep 12;19(1):228. Epub 2018 Sep 12.

UCL Centre for Nephrology, Royal Free Hospital, London, NW3 2PF, UK.

Background: Anti-glomerular basement membrane (GBM) antibodies are highly specific for Goodpasture's or anti-GBM disease, in which they are generally directed against the non-collagenous (NC1) domain of the alpha 3 chain of type IV collagen(α3(IV)), and less commonly, toward the α 4(IV) or α 5(IV) chains, which form a triple helical structure in GBM and alveolar basement membrane (ABM). Alterations in the hexameric structure of the NC1 (α3 (IV)), allows novel epitopes to be exposed and an immune response to develop, with subsequent linear antibody deposition along the GBM, leading to a crescentic glomerulonephritis. Positive anti-GBM antibodies are assumed to be pathogenic and capable of binding GBM in vivo, especially in the context of rapidly progressive glomerulonephritis. Read More

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http://dx.doi.org/10.1186/s12882-018-1027-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6136232PMC
September 2018
2 Reads

Impact of MPO-ANCA-mediated oxidative imbalance on renal vasculitis.

Am J Physiol Renal Physiol 2018 Dec 12;315(6):F1769-F1776. Epub 2018 Sep 12.

Department of Internal Medicine and Multi-Organic Diseases, University Hospital , Montpellier , France.

Glomerulonephritis is a severe complication of microscopic polyangiitis (MPA), a small-vessel vasculitis associated with anti-myeloperoxidase antibodies (MPO-ANCA). We previously showed the pathogenic effects of MPO-ANCA that activate MPO to trigger an oxidative burst mainly through HOCl production, contributing to endothelial injury and lung fibrosis. The aim of this study was to investigate the relationship between MPO-induced oxidative stress, anti-oxidant defenses and renal histological lesions in MPA patients. Read More

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http://dx.doi.org/10.1152/ajprenal.00111.2018DOI Listing
December 2018
4 Reads

Anca-associated crescentic glomerulonephritis in a child with isolated renal involvement.

J Bras Nefrol 2018 Sep 6. Epub 2018 Sep 6.

Department of Pediatric Nephrology and Pathology, School of Medicine, Kocaeli University, Kocaeli, Turkey.

Pauci-immune glomerulonephritis (GN) is more common in elderly people compared to children and the etiology is not completely understood yet. Antineutrophil cytoplasmic antibody (ANCA) positivity occurs in 80% of the patients. We report a case of a 7-year-old girl who presented with malaise and mildly elevated creatinine diagnosed as ANCA-associated pauci-immune crescentic glomerulonephritis with crescents in 20 of 25 glomeruli (80%). Read More

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S
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http://dx.doi.org/10.1590/2175-8239-jbn-2018-0062DOI Listing
September 2018
16 Reads

Staphylococcal Infection-Related Glomerulonephritis With Cryoglobulinemic Features.

Kidney Int Rep 2018 Sep 2;3(5):1128-1134. Epub 2018 Jun 2.

Department of Pathology, Sharp Memorial Hospital, San Diego, California, USA.

Introduction: Staphylococcal infection-related glomerulonephritis (GN) has been shown to represent a unique form of infection-related GN that contains IgA-dominant deposits and is often seen concurrently with the bacterial infection. Biopsies commonly reveal an endocapillary proliferative and/or exudative or mesangial proliferative GN. Rare cases have been reported to show cryoglobulin-like features, including hyaline pseudothrombi and wireloop deposits; however, detailed characterization of these cases is lacking. Read More

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http://dx.doi.org/10.1016/j.ekir.2018.05.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6127436PMC
September 2018
6 Reads

Case Report: Patient with Hepatitis C, p-ANCA, and Cryoglobulin Antibodies Presenting with Necrotizing Crescentic p-ANCA Glomerulonephritis.

Case Rep Nephrol Dial 2018 May-Aug;8(2):161-170. Epub 2018 Aug 10.

UCLA David Geffen School of Medicine, Westwood, California, USA.

Hepatitis C (HCV) infection has a prevalence of 3 million infected individuals in the United States, according to recent Center for Disease Control reports, and can have various renal manifestations. Cryoglobulins, antibodies that precipitate at colder temperatures in vitro, are a relatively common cause of renal disease in HCV infection. The cryoglobulin proteins can form occlusive aggregates in small glomerular capillary lumina or deposit in other areas of the glomerulus, resulting in hypocomplementemia, proteinuria, hematuria, and renal injury. Read More

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https://www.karger.com/Article/FullText/491629
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http://dx.doi.org/10.1159/000491629DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6120379PMC
August 2018
7 Reads

Antineutrophil cytoplasmic antibody and/or antiglomerular basement membrane antibody associated crescentic glomerulonephritis in combination with IgG4-related tubulointerstitial nephritis.

Clin Exp Rheumatol 2018 Aug 29. Epub 2018 Aug 29.

Division of Nephrology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.

Objectives: Immunoglobulin G4 (IgG4)-related disease (IgG4-RD) is an immune-mediated fibroinflammatory disorder and is characterised by elevated serum IgG4 concentrations and dense lymphoplasmacytic infiltrate rich in IgG4+ plasma cells. IgG4-related tubulointerstitial nephritis (IgG4-TIN) is the most common manifestation of IgG4-related kidney disease (IgG4-RKD). We report four cases of kidney injury with concurrent IgG4-TIN and crescentic glomerulonephritis confirmed by renal pathology. Read More

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August 2018
4 Reads
2.724 Impact Factor

The diagnostic dilemma of new-onset crescentic glomerulonephritis following pre-eclampsia.

Clin Nephrol 2018 Dec;90(6):434-436

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http://dx.doi.org/10.5414/CN109469DOI Listing
December 2018
3 Reads
1.232 Impact Factor

Primary Vasculitis in Childhood: GPA and MPA in Childhood.

Front Pediatr 2018 16;6:226. Epub 2018 Aug 16.

The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.

Childhood onset anti-neutrophilic cytoplasmic antibody (ANCA) associated vasculitis (AAV) is a rare group of primary systemic vasculitides affecting medium and small blood vessels. AAV includes granulomatosis with polyangiitis (GPA), microscopic polyangiitis (MPA), eosinophilic granulomatosis with polyangiitis (EGPA), and renal limited ANCA vasculitis. These disorders are associated with severe clinical manifestations, frequent relapses and a high cumulative morbidity, and often present with multisystem involvement. Read More

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https://www.frontiersin.org/article/10.3389/fped.2018.00226/
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http://dx.doi.org/10.3389/fped.2018.00226DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6107029PMC
August 2018
18 Reads

An uncommon cause of rapidly progressive renal failure in a lupus patient: Pauci-immune crescentic glomerulonephritis.

Saudi J Kidney Dis Transpl 2018 Jul-Aug;29(4):989-992

Department of Nephrology and Clinical Transplantation, Institute of Kidney Diseases and Research Center, Dr. H. L. Trivedi Institute of Transplantation Sciences, Ahmedabad, Gujarat, India.

We report a case of systemic lupus erythematosus (SLE) who presented with rapidly progressive renal failure (RPRF) with positive antinuclear antibody (ANA) and anti-double-stranded DNA (dsDNA) antibody and active urinary sediment in the form of microscopic hematuria and proteinuria. Provisional clinical diagnosis of lupus nephritis was made. Renal biopsy showed pauci-immune crescentic glomerulonephritis, the diagnosis of which was supported by positive serum anti-MPO antibody. Read More

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http://dx.doi.org/10.4103/1319-2442.239632DOI Listing
August 2018
2 Reads

Sarcoidosis with multiple organ involvement associated with necrotizing crescentic glomerulonephritis.

Saudi J Kidney Dis Transpl 2018 Jul-Aug;29(4):979-984

Department of Radiology, King Fahd Hospital of the University, Imam Abdulrahman Bin Faisal University, Al-Khobar, Saudi Arabia.

We report a case of a young Saudi male who presented with generalized body weakness and easy fatigability associated with fever, night sweating, loss of weight and appetite, and renal impairment. He was diagnosed as a case of sarcoidosis, and renal biopsy report was consistent with necrotizing crescentic glomerulonephritis (GN). Immunosuppressive medication was started to help halting the progression to renal failure and stabilize renal function. Read More

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http://www.sjkdt.org/text.asp?2018/29/4/979/239649
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http://dx.doi.org/10.4103/1319-2442.239649DOI Listing
August 2018
16 Reads

Mycobacterium Kansasii Infection and Microscopic Polyangiitis: An Unexpected Association.

Cureus 2018 Jun 18;10(6):e2831. Epub 2018 Jun 18.

Medicine, University of Arizona College of Medicine/mihs, Phoenix, USA.

 () is a nontuberculous mycobacterium, which mainly infects the lungs in immunocompromised patients. We present here the case of a 27-year-old immunocompetent patient who developed pulmonary-renal syndrome, manifested with lung cavitation, miliary nodules, and necrotizing glomerulonephritis accompanied by elevated titers of myeloperoxidase antibody. Cultures from bronchoalveolar lavage were positive for , and the patient was treated with an anti-mycobacterial regimen. Read More

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http://dx.doi.org/10.7759/cureus.2831DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6101464PMC
June 2018
20 Reads

Standardized classification and reporting of glomerulonephritis.

Nephrol Dial Transplant 2019 Feb;34(2):193-199

Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN, USA.

A kidney biopsy is done to determine the etiology of the glomerulonephritis (GN) and the severity of the lesion, to identify whether other lesions, related to or not related to the GN, are present on the kidney biopsy and finally to ascertain the extent of chronicity of the GN. The etiology of GN is based on the classification of GN into five groups: immune complex-mediated GN, antineutrophil cytoplasmic antibody (ANCA)-associated GN, anti-glomerular basement membrane (GBM) GN, monoclonal immunoglobulin-mediated GN and C3 glomerulopathy. Immune complex GN includes multiple specific diseases such as lupus nephritis, IgA nephropathy, infection-related GN and fibrillary GN. Read More

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http://dx.doi.org/10.1093/ndt/gfy220DOI Listing
February 2019
7 Reads

ANCA-associated vasculitis in scleroderma: A renal perspective
.

Clin Nephrol 2018 Dec;90(6):413-418

Aims: Overlap syndrome of ANCA-associated vasculitis (AAV) and scleroderma (SSc) is rare with conflicting data on renal outcomes. We describe the clinical characteristics and treatment outcome of ANCA-associated glomerulonephritis (AAG) in SSc patients followed at a single center.

Materials And Methods: We conducted a retrospective study of 3,570 patients in our SSc database to identify SSc patients who subsequently developed AAV with renal involvement. Read More

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http://dx.doi.org/10.5414/CN109445DOI Listing
December 2018
7 Reads

Neutropenia related to an azathioprine metabolic disorder induced by an inosine triphosphate pyrophosphohydrolase (ITPA) gene mutation in a patient with PR3-ANCA-positive microscopic polyangiitis
.

Clin Nephrol 2018 Nov;90(5):363-369

A 68-year-old Japanese man was monitored for chronic kidney disease (CKD), with unknown primary disease starting in 2014. His serum creatinine (sCr) was stable at ~ 2.5 mg/dL for ~ 2 years. Read More

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http://dx.doi.org/10.5414/CN109383DOI Listing
November 2018
18 Reads

An evaluation of the 2010 histopathological classification of anti-neutrophil cytoplasmic antibody (ANCA)-associated glomerulonephritis: a Bayesian network meta-analysis.

Int Urol Nephrol 2018 Oct 25;50(10):1853-1861. Epub 2018 Jul 25.

Department of Nephrology, First Affiliated Hospital of Chongqing Medical University, Chongqing, China.

Background: In 2010, a new histopathological classification of ANCA-associated glomerulonephritis (ANCA-GN) based on four categories (focal, crescentic, mixed, and sclerotic) was proposed to predict renal outcome. However, this classification was the source of much debate in different populations. We aimed to evaluate this classification scheme in terms of renal survival using Bayesian network meta-analysis. Read More

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http://dx.doi.org/10.1007/s11255-018-1941-7DOI Listing
October 2018
3 Reads

Double-positive with positive anti-glomerular basement membrane antibody and ANCA-positive disease in a patient with dermatomyositis.

BMJ Case Rep 2018 Jul 24;2018. Epub 2018 Jul 24.

Nephrology, Johns Hopkins University, Baltimore, Maryland, USA.

Approximately one in four patients (23.3%) with inflammatory myositis including dermatomyositis can require evaluation for acute kidney injury. The main cause of kidney injury is acute tubular necrosis from medications or myoglobinuria, though clinicians should be aware of a wide variety of possible aetiologies. Read More

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http://dx.doi.org/10.1136/bcr-2018-224475DOI Listing
July 2018
4 Reads