2,350 results match your criteria Glomerulonephritis Crescentic


Renal proximal tubular epithelial cells exert immunomodulatory function by driving inflammatory CD4+ T-cell responses.

Am J Physiol Renal Physiol 2019 Apr 24. Epub 2019 Apr 24.

Institute of Experimental Immunology and Hepatology, University Medical Center Hamburg-Eppendorf, Germany.

In immune-mediated glomerular diseases like crescentic glomerulonephritis (cGN), inflammatory CD4 T cells accumulate within the tubulointerstitial compartment in close contact to proximal and distal tubular epithelial cells and drive renal inflammation and tissue damage. However, whether renal epithelial cell populations play a role in the pathogenesis of cGN by modulating CD4 T-cell responses is less clear. In this study, we aim at investigating the potential of renal epithelial cells to function as antigen-presenting cells (APCs) thereby stimulating CD4 T-cell responses . Read More

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http://dx.doi.org/10.1152/ajprenal.00427.2018DOI Listing

Systemic p-ANCA vasculitis with fatal outcome, arising in the setting of methimazole use.

Clin Nephrol Case Stud 2019 16;7:23-26. Epub 2019 Apr 16.

Department of Pathology and Laboratory Medicine and.

Here we report a fatal case of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) due to methimazole use in a 64-year-old woman. She was initially hospitalized for abdominal pain and possible colitis, and subsequently developed hematuria, renal failure, and hemoptysis. The serologic work-up revealed positive antinuclear antibody (ANA) and perinuclear-antineutrophilic cytoplasm antibodies (p-ANCA), with positive antimyeloperoxidase. Read More

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http://dx.doi.org/10.5414/CNCS109759DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6470634PMC

Pauci-Immune Crescentic Glomerulonephritis due to Disseminated Histoplasmosis.

Kidney Int Rep 2019 Apr 9;4(4):629-632. Epub 2019 Jan 9.

Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.

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http://dx.doi.org/10.1016/j.ekir.2018.12.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451085PMC
April 2019
1 Read

Estimating the Change in Renal Function During the First Year of Therapy in ANCA-Associated Vasculitis.

Kidney Int Rep 2019 Apr 13;4(4):594-602. Epub 2019 Feb 13.

Nephrology Division, Hôpital du Sacré-Coeur de Montréal, Québec, Canada.

Introduction: Studies in antineutrophil cytoplasmic autoantibody (ANCA)-associated vasculitis (AAV) consistently show that the months following diagnosis have the greatest impact on the long-term renal function. Yet, it remains uncertain how much early gain should be expected with treatment. We sought to determine the factors associated with the change in glomerular filtration rate (GFR) throughout the first year. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S24680249193004
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http://dx.doi.org/10.1016/j.ekir.2019.02.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451086PMC
April 2019
2 Reads

Crescentic Glomerulonephritis and Membranous Nephropathy: An Unusual Association.

Indian J Nephrol 2019 Mar-Apr;29(2):146-147

Department of Nephrology-Dialysis, Military Hospital Mohammed V, Rabat, Morocco.

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http://www.indianjnephrol.org/preprintarticle.asp?id=249859
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http://dx.doi.org/10.4103/ijn.IJN_132_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440324PMC
April 2019
4 Reads

Cytomegalovirus Induced Collapsing Glomerulopathy and Necrotizing Glomerulonephritis in a Renal Allograft Recipient.

Indian J Nephrol 2019 Mar-Apr;29(2):122-124

Department of Pathology, Center for Renal and Urological Pathology, Chennai, Tamil Nadu, India.

In renal allograft recipients, cytomegalovirus (CMV) typically causes tubulointerstitial nephritis. Only rarely glomeruli are involved. We present a rare case of CMV with collapsing glomerulopathy, necrotizing glomerulonephritis, and crescent formation in a renal allograft recipient. Read More

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http://www.indianjnephrol.org/preprintarticle.asp?id=252210
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http://dx.doi.org/10.4103/ijn.IJN_375_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440330PMC
April 2019
2 Reads

Local miscommunications between glomerular cells as potential therapeutic targets for crescentic glomerulonephritides.

Nephrol Ther 2019 Apr;15 Suppl 1:S1-S5

Inserm, Paris Cardiovascular Centre (Parcc), 56, rue Leblanc, 75015 Paris, France; Université Paris Descartes, Sorbonne Paris Cité, 12, rue de l'École-de-Médecine, 75006 Paris, France. Electronic address:

Necrotizing and crescentic rapidly progressive glomerulonephritis or crescentic glomerulonephritis is one of the severest forms of acquired glomerular diseases with significant mortality. Risk of end-stage renal failure at 5 years is near 30%, with a number of patients developing chronic kidney disease. Currently, autoimmune crescentic glomerulonephritides are treated with broad-spectrum immunosuppression inducing remission of the injury in the majority of patients. Read More

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http://dx.doi.org/10.1016/j.nephro.2019.03.006DOI Listing
April 2019
1 Read

Cast nephropathy associated with monoclonal immunoglobulin M-secreting mucosa-associated lymphoid tissue B-cell lymphoma
.

Clin Nephrol 2019 Apr 9. Epub 2019 Apr 9.

The kidney is among the various anatomical sites involved in mucosa-associated lymphoid tissue (MALT) lymphoma. A variety of renal pathological types, including membranous glomerulopathy, membranoproliferative glomerulonephritis, crescentic IgA nephropathy, minimal change disease, and cryoglobulinemic glomerulopathy, have been reported in MALT lymphoma patients. However, cast nephropathy is extremely rare in MALT lymphoma. Read More

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http://dx.doi.org/10.5414/CN109682DOI Listing
April 2019
4 Reads

Microscopic polyangiitis associated with thymic tumor: a case report and review of the literature.

BMC Nephrol 2019 Apr 8;20(1):123. Epub 2019 Apr 8.

Department of Nephrology, Tokyo Medical University Ibaraki Medical Center, 3-20-1 Chuo, Ami, Ibaraki, 300-0395, Japan.

Background: Thymic hyperplasia and thymic epithelial tumor (thymoma) have been associated with a variety of autoimmune diseases. Renal involvement has been reported in patients with thymoma. Minimal change disease and membranous nephropathy are frequently observed in glomerular lesions of thymoma patients, but ANCA-associated renal vasculitis is rare. Read More

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http://dx.doi.org/10.1186/s12882-019-1319-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454690PMC
April 2019
1 Read

Rapidly Progressive Glomerulonephritis Secondary to IgA Nephropathy in a Patient with Systemic Lupus Erythematosus.

Case Rep Nephrol 2019 5;2019:8354823. Epub 2019 Mar 5.

Department of Internal Medicine, Division of Nephrology, Houston, TX, USA.

Lupus nephritis is a common manifestation of systemic lupus erythematosus (SLE). IgA nephropathy is a common type of primary glomerulonephritis. Renal manifestations in SLE patients are often due to lupus nephritis; however, renal diseases unrelated to lupus nephritis are rarely reported. Read More

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https://www.hindawi.com/journals/crin/2019/8354823/
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http://dx.doi.org/10.1155/2019/8354823DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425374PMC
March 2019
4 Reads

Anca negative pauci-immune crescentic glomerulonephritis and mixed connective tissue disease: a case study.

J Bras Nefrol 2019 Mar 18. Epub 2019 Mar 18.

Hospital Beatriz Angelo, Loures, Portugal.

One of the most common causes of rapidly progressive glomerulonephritis (RPGN) is pauci-immune crescentic glomerulonephritis (CrGN). In the majority of cases, this condition has a positive serologic marker, the anti-neutrophil cytoplasmic antibodies (ANCAs), but in approximately 10% there are no circulating ANCAs, and this subgroup has been known as the ANCA-negative pauci-immune CrGN. RPGN can be associated with systemic diseases, but there are only few case reports describing the association with mixed connective tissue disease (MCTD). Read More

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http://dx.doi.org/10.1590/2175-8239-JBN-2019-0003DOI Listing
March 2019
1 Read

Role of CD8+ T cells in crescentic glomerulonephritis.

Nephrol Dial Transplant 2019 Mar 16. Epub 2019 Mar 16.

Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Crescentic glomerulonephritis (cGN) comprises three main types according to the pathogenesis and immunofluorescence patterns: anti-glomerular basement membrane antibody cGN, vasculitis-associated cGN and post-infectious immune complex cGN. In this brief review of the immune-pathogenesis of cGN, the focus is mainly on the role of CD8+ T cells in the progression of cGN. Under control conditions, Bowman's capsule (BC) provides a protected immunological niche by preventing access of cytotoxic CD8+ T cells to Bowman's space and thereby podocytes. Read More

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http://dx.doi.org/10.1093/ndt/gfz043DOI Listing
March 2019
2 Reads

Anti-LRP2 Nephropathy With Abundant IgG4-Positive Plasma Cells: A Case Report.

Am J Kidney Dis 2019 Mar 12. Epub 2019 Mar 12.

Department of Pathology, Oregon Health & Science University, Portland, OR. Electronic address:

In older adults, the most common kidney biopsy diagnoses include pauci-immune crescentic glomerulonephritis, membranous nephropathy, and focal segmental glomerulosclerosis. Recently, investigators described a small series of older patients (aged 66-80 years) with acute kidney injury and a kidney biopsy demonstrating tubular basement membrane (TBM) immune deposits of polytypic immunoglobulin G (IgG) and C3, acute tubular injury, and tubulointerstitial inflammation. They identified a circulating antibody against kidney tubular low-density lipoprotein (LDL) receptor-related protein 2 (LRP2; also known as megalin) in patients' sera and colocalization of LRP2 with IgG in TBM deposits. Read More

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http://dx.doi.org/10.1053/j.ajkd.2018.12.039DOI Listing
March 2019
1 Read
5.900 Impact Factor

Plasmapheresis and corticosteroids in infective endocarditis-related crescentic glomerulonephritis.

BMJ Case Rep 2019 Mar 14;12(3). Epub 2019 Mar 14.

Division of Nephrology, University of Missouri School of Medicine, Columbia, Missouri, USA.

Infective endocarditis (IE)-related glomerulonephritis (GN) typically resolves with the treatment of IE. A 59-year-old woman with a baseline creatinine of 0.7 mg/dL presented with rash on her legs, night sweats and weight loss for 3 weeks. Read More

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http://dx.doi.org/10.1136/bcr-2018-227672DOI Listing
March 2019
4 Reads

[Rapid progressive glomerulonephritis].

Authors:
Marion Haubitz

Internist (Berl) 2019 Mar 13. Epub 2019 Mar 13.

Medizinische Klinik III - Nieren- und Hochdruckerkrankungen, Klinikum Fulda gAG, Universitätsmedizin Marburg - Campus Fulda, Pacelliallee 4, 36043, Fulda, Deutschland.

The rapid progressive glomerulonephritis is an emergency case. Renal function is rapidly lost within weeks or a few months (rarely within days) due to necrotizing extracapillary proliferative crescentic glomerulonephritis. Early diagnosis and treatment improve prognosis, as the best prognostic marker is creatinine when treatment is initiated. Read More

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http://link.springer.com/10.1007/s00108-019-0575-x
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http://dx.doi.org/10.1007/s00108-019-0575-xDOI Listing
March 2019
5 Reads

End-stage renal disease secondary to anti-glomerular basement membrane disease in a child with common variable immunodeficiency.

Clin Nephrol Case Stud 2019 1;7:1-6. Epub 2019 Feb 1.

Division of Pediatric Nephrology, Department of Pediatrics.

Background: Anti-glomerular basement membrane (GBM) disease is caused by autoantibodies against the α3-chain of type IV collagen in the GBM. Common variable immunodeficiency (CVID) is a primary immunodeficiency manifested by hypogammaglobulinemia, inability to make functional antibody, and recurrent infections. This report extends the phenotype of CVID-associated autoimmune diseases to include anti-GBM disease. Read More

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http://dx.doi.org/10.5414/CNCS109510DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374989PMC
February 2019
2 Reads

[Effect of Glucocorticoid Pulse Therapy on Short-term Prognosis of Anti-neutrophil Cytoplasmic Antibodies-associated Glomerulonephritis].

Zhongguo Yi Xue Ke Xue Yuan Xue Bao 2019 Feb;41(1):68-74

Department of Nephrology,PUMC Hospital,CAMS and PUMC,Beijing 100730,China.

Objective To investigate the prognosis predictors of anti-neutrophil cytoplasmic antibody(ANCA)-associated glomerulonephritis treated with glucocorticoid(GC).Methods The clinicopathological data of patients with biopsy-confirmed ANCA-associated glomerulonephritis were retrospective analyzed by retrieving the medical database in Peking Union Medical College Hospital from January 2000 to May 2015. Pathological categories were re-classified. Read More

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http://dx.doi.org/10.3881/j.issn.1000-503X.10404DOI Listing
February 2019
2 Reads

Spectrum of biopsy proven renal disease in northern India: a single centre study.

Nephrology (Carlton) 2019 Mar 4. Epub 2019 Mar 4.

Department of Nephrology, All India Institute of Medical Sciences, New Delhi, India-110029.

Aim: Pattern of kidney diseases varies across geographies due to multiple factors. There is a paucity of information from South Asia due to absence of nationwide/regional biopsy registries. This study aimed to delineate the spectrum of renal parenchymal diseases in our region. Read More

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http://doi.wiley.com/10.1111/nep.13582
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http://dx.doi.org/10.1111/nep.13582DOI Listing
March 2019
14 Reads

Successful use of rituximab for hydralazine-induced anti-neutrophil cytoplasmic antibodies-associated vasculitis.

Saudi J Kidney Dis Transpl 2019 Jan-Feb;30(1):226-230

Department of Medicine, Division of Nephrology, Washington University School of Medicine, St. Louis, MO, USA.

Hydralazine is a commonly used anti-hypertensive medication. It can, however, contribute to the development of autoimmunity, in the form of drug-induced lupus and anti-neutrophil cytoplasmic antibodies-associated vasculitis. We report a 45-year-old patient with hypertension managed with hydralazine for four years who presented with rapidly progressive glomerulonephritis (RPGN), requiring hemodialysis, and diffuse alveolar hemorrhage (DAH), requiring mechanical ventilation, and extracorporeal membrane oxygenation. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6435256PMC
February 2019

Clinical Implications of Excessive Neutrophil Extracellular Trap Formation in Renal Autoimmune Diseases.

Kidney Int Rep 2019 Feb 19;4(2):196-211. Epub 2018 Nov 19.

Department of Nephrology, Leiden University Medical Centre, Leiden, The Netherlands.

Neutrophil extracellular traps (NETs) are extracellular DNA structures covered with antimicrobial peptides, danger molecules, and autoantigens that can be released by neutrophils. NETs are an important first-line defense mechanism against bacterial, viral, fungal, and parasitic infections, but they can also play a role in autoimmune diseases. NETs are immunogenic and toxic structures that are recognized by the autoantibodies of patients with antineutrophil cytoplasmic antibodies-associated vasculitis (AAV) (i. Read More

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http://dx.doi.org/10.1016/j.ekir.2018.11.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365354PMC
February 2019
1 Read

The co-inhibitory molecule PD-L1 contributes to regulatory T cell-mediated protection in murine crescentic glomerulonephritis.

Sci Rep 2019 Feb 14;9(1):2038. Epub 2019 Feb 14.

Institute of Experimental Immunology and Hepatology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Immune-mediated glomerular diseases like crescentic glomerulonephritis (cGN) are driven by inappropriately regulated cellular and humoral immune responses subsequently leading to renal tissue injury. Recent studies demonstrated the crucial role for regulatory T cells (Tregs) in suppressing pathogenic T-cell responses during nephrotoxic nephritis (NTN), a murine model of cGN. However, mechanisms of immune regulation in cGN are less clear. Read More

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http://dx.doi.org/10.1038/s41598-018-38432-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6375967PMC
February 2019
1 Read

Dual anti-neutrophil cytoplasmic antibody and anti-glomerular basement membrane antibody-positive crescent glomerulonephritis in a patient with monoclonal gammopathy of undetermined significance: A case report.

Medicine (Baltimore) 2019 Feb;98(7):e14557

Department of Nephrology.

Rationale: Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) and anti-glomerular basement membrane (GBM) antibody disease are both rare autoimmune diseases. Monoclonal gammopathy of undetermined significance (MGUS) is one of the most common causes of plasma cell dyscrasias (PCD). The three entities can cause renal lesions via different mechanisms and, however, they have not been reported in a single patient with renal lesion. Read More

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http://dx.doi.org/10.1097/MD.0000000000014557DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6408057PMC
February 2019
1 Read

Distinction between MPO-ANCA and PR3-ANCA-associated glomerulonephritis in Chinese patients: a retrospective single-center study.

Clin Rheumatol 2019 Feb 8. Epub 2019 Feb 8.

Jinling Clinical Medical College of Nanjing Medical University, Nanjing, China.

Objectives: To retrospectively investigate the clinical and histological features and outcomes of ANCA-associated glomerulonephritis (AAGN) with different ANCA serotypes.

Method: A total of 467 AAGN patients were divided into MPO-AAGN (MPO) and PR3-AAGN (PR3) groups according to ANCA serotype. Clinical and histological features and renal outcomes were compared. Read More

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http://dx.doi.org/10.1007/s10067-019-04458-9DOI Listing
February 2019
7 Reads
1.774 Impact Factor

Endogenous IL-22 is dispensable for experimental glomerulonephritis.

Am J Physiol Renal Physiol 2019 Apr 6;316(4):F712-F722. Epub 2019 Feb 6.

Third Department of Medicine, University Medical Center Hamburg-Eppendorf , Hamburg , Germany.

In recent years, the cytokine interleukin (IL)-22 attracted considerable attention due to its important immunoregulatory function in barrier tissues, such as the gut, lung, and skin. Although a regenerative role of IL-22 in renal tubular damage has been demonstrated, the role of IL-22 in the immunopathogenesis of glomerular injury is still unknown. Here, we demonstrate that the IL-22 receptor is expressed in the glomerular compartment of the kidney and that IL-22 expression increases in the renal cortex after induction of glomerular injury in a mouse model for crescentic glomerulonephritis (cGN, nephrotoxic nephritis). Read More

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http://dx.doi.org/10.1152/ajprenal.00303.2018DOI Listing
April 2019
3 Reads

A case of aggressive atypical anti-GBM disease complicated by CMV pneumonitis.

BMC Nephrol 2019 Jan 31;20(1):29. Epub 2019 Jan 31.

Department of Pathology and Laboratory Medicine, Cumming School of Medicine, University of Calgary, Foothills Medical Center, 1403 29 St NW, Calgary, AB, T2N 2T9, Canada.

Background: Anti-glomerular basement membrane (anti-GBM) disease is characterized by circulating IgG glomerular basement membrane antibodies and is clinically expressed as a rapidly progressive crescentic glomerulonephritis (GN), with 30-60% of patients also developing pulmonary hemorrhage. Classically, the renal biopsy shows glomerular crescent formation, bright linear staining of glomerular basement membranes (GBM) for IgG on direct immunofluorescence (IF), and the serologic presence of circulating anti-GBM antibodies. Recently, patients with linear IgG IF staining, undetectable circulating anti-GBM antibodies and glomerular changes atypical for anti-GBM disease have been described as "atypical anti-GBM disease", with a distinctly more benign clinical course than typical anti-GBM disease. Read More

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http://dx.doi.org/10.1186/s12882-019-1227-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357502PMC
January 2019
5 Reads

Development of anti-glomerular basement membrane glomerulonephritis during the course of IgA nephropathy: a case report.

BMC Nephrol 2019 Jan 25;20(1):25. Epub 2019 Jan 25.

Department of Nephrology and Blood Purification, Kidney Disease Center, Tokyo Medical University Hachioji Medical Center, 1163 Tatemachi, Hachioji, Tokyo, 193-0998, Japan.

Background: Anti-glomerular basement membrane (GBM) glomerulonephritis does not usually coexist with another glomerulonephritis such as IgA nephropathy. We present a rare case having a combination of these two diseases, and furthermore, histological evaluation could be performed before and after the development of anti-GBM glomerulonephritis over a period of only10 months.

Case Presentation: A 66-year-old woman was admitted with complaints of microscopic hematuria and mild proteinuria for the past 3 years. Read More

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http://dx.doi.org/10.1186/s12882-019-1207-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347754PMC
January 2019
8 Reads

Infliximab-associated focal segmental glomerulosclerosis in a patient with ankylosing spondylitis.

Rheumatol Int 2019 Mar 23;39(3):561-567. Epub 2019 Jan 23.

Division of Rheumatology, Department of Internal Medicine, Dokuz Eylul University School of Medicine, Izmir, Turkey.

The introduction of tumor necrosis factor-alpha (TNF-α)-targeting drugs has given new opportunities in the treatment of various inflammatory rheumatic diseases and has been the most important development in the treatment of spondyloarthritis (SpA). However, the increasing use and longer follow-up periods of treatment also pose risks of developing various adverse effects ranging from common ones including infections to uncommon renal complications. This report describes a case of infliximab-induced focal segmental glomerulosclerosis (FSGS) in a 40-year-old female patient with ankylosing spondylitis (AS) who presented with asymptomatic proteinuria and microscopic hematuria. Read More

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http://link.springer.com/10.1007/s00296-019-04241-8
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http://dx.doi.org/10.1007/s00296-019-04241-8DOI Listing
March 2019
14 Reads

TRPC6 inactivation does not affect loss of renal function in nephrotoxic serum glomerulonephritis in rats, but reduces severity of glomerular lesions.

Biochem Biophys Rep 2019 Mar 8;17:139-150. Epub 2019 Jan 8.

Department of Biology and Biochemistry, University of Houston, Houston, TX, USA.

Canonical transient receptor potential-6 (TRPC6) channels have been implicated in a variety of chronic kidney diseases including familial and acquired forms of focal and segmental glomerulosclerosis (FSGS) and renal fibrosis following ureteral obstruction. Here we have examined the role of TRPC6 in progression of inflammation and fibrosis in the nephrotoxic serum (NTS) model of crescentic glomerulonephritis. This was assessed in rats with non-functional TRPC6 channels due to genomic disruption of an essential domain in TRPC6 channels ( rats) and wild-type littermates ( rats). Read More

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http://dx.doi.org/10.1016/j.bbrep.2018.12.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6325086PMC
March 2019
2 Reads

Role of regulatory T cells in experimental autoimmune glomerulonephritis.

Am J Physiol Renal Physiol 2019 Mar 16;316(3):F572-F581. Epub 2019 Jan 16.

Institute of Immunology, University Medical Center Hamburg-Eppendorf , Hamburg , Germany.

Anti-glomerular basement membrane (anti-GBM) disease is characterized by antibodies and T cells directed against the Goodpasture antigen, the noncollagenous domain of the α3-chain of type IV collagen [α3(IV)NC1] of the GBM. Consequences are the deposition of autoantibodies along the GBM and the development of crescentic glomerulonephritis (GN) with rapid loss of renal function. Forkhead box protein P3 (Foxp3) regulatory T (Treg) cells are crucial for the maintenance of peripheral tolerance to self-antigens and the prevention of immunopathology. Read More

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http://dx.doi.org/10.1152/ajprenal.00558.2018DOI Listing
March 2019
4 Reads

Clinical outcomes in patients with biopsy-proved diabetic nephropathy compared to isolated lupus or crescentic glomerulonephritis.

Diabetes Res Clin Pract 2019 Feb 11;148:144-151. Epub 2019 Jan 11.

Renal Division, Department of Internal Medicine, National Taiwan University Hospital, College of Medicine, National Taiwan University, No. 7, Chung Shan S. Rd., Zhongzheng Dist., Taipei City 10002, Taiwan. Electronic address:

Aims: Diabetic nephropathy (DMN) is usually diagnosed clinically without pathology, and the prognosis of which compared to non-diabetic renal diseases has rarely been investigated especially in ethnic Chinese population. Here we reported the outcome of patients with biopsy-proved DMN compared to those with isolated crescentic glomerulonephritis (GN) or lupus nephritis (LN).

Methods: This retrospective observational study included patients with DMN (n = 55), crescentic GN (n = 48) and LN (n = 82) from an original cohort of 987 adult patients who underwent kidney biopsy. Read More

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http://dx.doi.org/10.1016/j.diabres.2019.01.014DOI Listing
February 2019
5 Reads

Cerebral venous sinus thrombosis as a warning signal for double positive crescentic glomerulonephritis in a young male with complete renal recovery.

Saudi J Kidney Dis Transpl 2018 Nov-Dec;29(6):1488-1493

Department of Renal Pathology, Lal Path Lab, New Delhi, India.

Double positive crescentic glomerulonephritis is relatively rare in young population and has variable outcomes. Although increased incidence of deep venous thrombosis in antineutrophil cytoplasmic antibody-associated vasculitis has been reported, cerebral venous sinus thrombosis (CVT) is very rare. We present a young male who presented with CVT followed by rapidly progressive crescentic glomerulonephritis and with appropriate therapeutic modalities he had complete renal and partial neurological recovery. Read More

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http://dx.doi.org/10.4103/1319-2442.248291DOI Listing
December 2018
154 Reads

ANCA-Associated Necrotizing Glomerulonephritis Overlapping with Mesangial Proliferative Lupus Nephritis Refractory to Plasmapheresis, Steroid Pulse Therapy, and a Combination of Mycophenolate Mofetil and Rituximab.

Case Rep Rheumatol 2018 19;2018:3076806. Epub 2018 Nov 19.

Division of Rheumatology, SUNY Upstate Medical University, Syracuse, NY 13210, USA.

Necrotizing glomerulonephritis (GN) associated with antineutrophil cytoplasmic antibody (ANCA) has been increasingly recognized in the context of class III or IV lupus nephritis (LN), hereafter designated as . While this subset of GN appears to portend an unfavorable renal outcome, it is not clear whether it represents a distinct entity and benefits from a more aggressive therapy. We report a 78-year-old woman who presented with rapidly progressive GN and was found to have a double-stranded DNA (dsDNA) antibody, hypocomplementemia, antiphospholipid antibody, and strongly positive myeloperoxidase antibody. Read More

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http://dx.doi.org/10.1155/2018/3076806DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276453PMC
November 2018
3 Reads

A Case of Self-Limiting Crescentic Immunoglobulin A Glomerulonephritis Associated with Sternoclavicular Arthritis.

Case Rep Nephrol Dial 2018 Sep-Dec;8(3):246-252. Epub 2018 Nov 21.

Division of Nephrology and Hypertension, Department of Internal Medicine, St. Marianna University School of Medicine, Kanagawa, Japan.

Immunoglobulin (Ig) A glomerulonephritis (GN) is a heterogeneous disease affected by various factors. Genetic and other factors "hit" DNA, causing IgA malformation and ultimately glomerular injury. We describe a rare case of crescentic IgA GN with sternoclavicular (SC) arthritis in a 75-year-old woman. Read More

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https://www.karger.com/Article/FullText/494715
Publisher Site
http://dx.doi.org/10.1159/000494715DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276760PMC
November 2018
18 Reads

A rare case of Alport syndrome, atypical hemolytic uremic syndrome and Pauci-immune crescentic glomerulonephritis.

BMC Nephrol 2018 Dec 12;19(1):355. Epub 2018 Dec 12.

Department of Pathology, Stanford University, Stanford, CA, USA.

Background: Renal thrombotic microangiopathy (TMA) is occasionally seen in biopsies with pauci-immune necrotizing crescentic glomerulonephritis (PCGN). Recent study indicated that the complement activation is more prominent in the ANCA-negative glomerulonephritis.

Case Presentation: We report a case of concurrent TMA and PCGN without ANCA positivity. Read More

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http://dx.doi.org/10.1186/s12882-018-1170-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6291978PMC
December 2018

Activation of fibroblastic reticular cells in kidney lymph node during crescentic glomerulonephritis.

Kidney Int 2019 Feb 3;95(2):310-320. Epub 2018 Dec 3.

Transplantation Research Center, Brigham and Women's Hospital, Boston, Massachusetts, USA; Division of Renal Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA. Electronic address:

Crescentic glomerulonephritis is an inflammatory condition characterized by rapid deterioration of kidney function. Previous studies of crescentic glomerulonephritis have focused on immune activation in the kidney. However, the role of fibroblastic reticular cells, which reside in the stromal compartment of the kidney lymph node, has not been studied in this condition. Read More

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http://dx.doi.org/10.1016/j.kint.2018.08.040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6342621PMC
February 2019
8 Reads

Elevated Levels of Urinary Extracellular Vesicle Fibroblast-Specific Protein 1 in Patients with Active Crescentic Glomerulonephritis.

Nephron 2019 12;141(3):177-187. Epub 2018 Dec 12.

Department of Nephrology, Faculty of Medical Sciences, University of Fukui, Fukui, Japan.

Background/aims: Extracellular vesicles (EVs), including exosomes, are present in various bodily fluids, including urine. We and others previously reported that cells expressing fibroblast-specific protein 1 (FSP1) accumulate within damaged glomeruli, and that urinary FSP1, as well as urinary soluble CD163, could potentially serve as a biomarker of ongoing glomerular injury.

Methods: To test that idea, we collected urine samples from 37 patients with glomerular disease; purified the urinary EVs; characterized them using Nanosight, western blotting, and immunoelectron microscopy; and determined FSP1 and soluble CD163 levels using enzyme-linked immunosorbent assays. Read More

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http://dx.doi.org/10.1159/000495217DOI Listing
December 2018
9 Reads

Mechanisms and functions of IL-17 signaling in renal autoimmune diseases.

Mol Immunol 2018 12 15;104:90-99. Epub 2018 Nov 15.

III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Section of Translational Immunology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. Electronic address:

Immune-mediated glomerular diseases (glomerulonephritis) encompass a heterogeneous collection of diseases that cause inflammation within the glomerulus and other renal compartments with significant morbidity and mortality. In general, CD4 T cells orchestrate the immune response and play a unique role in autoimmune and chronic inflammatory diseases. In particular, the characterization of a distinct, IL-17 cytokines producing CD4 T cell subset named T17 cells has significantly advanced the current understanding of the pathogenic mechanisms of organ-specific immunity. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01615890183076
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http://dx.doi.org/10.1016/j.molimm.2018.09.005DOI Listing
December 2018
12 Reads

A case report of granulomatous polyangiitis complicated by tuberculous lymphadenitis.

Medicine (Baltimore) 2018 Oct;97(43):e12430

Lung Cancer and Respiratory Disease Center, Yamanashi Central Hospital.

Rational: Granulomatous polyangiitis (GPA) is a type of vasculitis involving medium and small arteries, typically affecting the upper and lower respiratory tract with coexisting glomerulonephritis. GPA is also characterized by necrotizing granulomatous inflammation and the presence of antineutrophil cytoplasm antibodies (ANCA). So far, various infections have lead to elevation of titers of serum ANCA, making it difficult to diagnose. Read More

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http://Insights.ovid.com/crossref?an=00005792-201810260-0000
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http://dx.doi.org/10.1097/MD.0000000000012430DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6221664PMC
October 2018
18 Reads

Prognostic Factors for Survival and Relapse in ANCA-Associated Vasculitis with Renal Involvement: A Clinical Long-Term Follow-Up Study.

Int J Nephrol 2018 16;2018:6369814. Epub 2018 Oct 16.

Abdomen Center, Nephrology, Helsinki University Hospital, Helsinki, Finland.

Aim: We describe the clinical pattern of ANCA-associated vasculitis (AAV) and assess long-term prognostic factors of patients and renal survival and relapse.

Methods: Data from 85 patients with renal biopsy-proven AAV at a single center with up to 20-year [median 16.2 years (95% CI 14. Read More

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https://www.hindawi.com/journals/ijn/2018/6369814/
Publisher Site
http://dx.doi.org/10.1155/2018/6369814DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6206576PMC
October 2018
33 Reads

Antiglomerular Basement Membrane Disease.

Semin Respir Crit Care Med 2018 08 7;39(4):494-503. Epub 2018 Nov 7.

Department of Medicine, Centre for Inflammatory Disease, Imperial College London, London, United Kingdom.

Antiglomerular basement membrane (anti-GBM) disease is a rare but life-threatening autoimmune vasculitis that is characterized by the development of pathogenic autoantibodies to type IV collagen antigens expressed in the glomerular and alveolar basement membranes. Once deposited in tissue, these autoantibodies incite a local capillaritis which manifests as rapidly progressive glomerulonephritis (GN) in 80 to 90% of patients, and with concurrent alveolar hemorrhage in ∼50%. A small proportion of cases may present with pulmonary disease in isolation. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/s-0038-1669413
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http://dx.doi.org/10.1055/s-0038-1669413DOI Listing
August 2018
14 Reads

Microscopic Polyangiitis: New Insights into Pathogenesis, Clinical Features and Therapy.

Authors:
Alexandre Karras

Semin Respir Crit Care Med 2018 08 7;39(4):459-464. Epub 2018 Nov 7.

Department of Nephrology, Hôpital Européen Georges Pompidou, Assistance Publique- Hôpitaux de Paris, Paris France.

Microscopic polyangiitis (MPA) is one of the main clinical presentations of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitides. Although the disease is defined by clinical and pathological criteria, the anti-myeloperoxidase (MPO) specificity of ANCAs is observed in almost 80% of MPA patients. The direct pathogenic role of anti-MPO antibodies has been proven in animal models, in which the disease was transmitted by transfer of anti-MPO antibodies or anti-MPO-specific splenocytes. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/s-0038-1673387
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http://dx.doi.org/10.1055/s-0038-1673387DOI Listing
August 2018
13 Reads

Bacterial endocarditis manifesting as autoimmune pulmonary renal syndrome: ANCA-associated lung hemorrhage and pauci-immune crescentic glomerulonephritis
.

Clin Nephrol 2018 Dec;90(6):431-433

The etiology of pulmonary renal syndrome can be broadly divided into infectious and autoimmune (predominantly ANCA vasculitis). The importance of timely differentiating between them stems from the deleterious effects of their respective treatment if misdiagnosed. Serology and tissue evaluation by pathology are employed to aid in this, however, in rare cases, this can be difficult. Read More

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http://dx.doi.org/10.5414/CN109495DOI Listing
December 2018
20 Reads

Patterns of renal involvement in a cohort of patients with inflammatory bowel disease in Egypt.

Acta Gastroenterol Belg 2018 Jul-Sep;81(3):381-385

Department of Medicine, Cairo University Hospital, Cairo, Egypt.

Background And Study Aim: Renal complications are frequent extraintestinal manifestations in inflammatory bowel disease (IBD). We aimed in our study to describe the spectrum of renal affection in our IBD patients.

Patients And Methods: This study is a retrospective analysis of renal biopsies done for IBD patients who developed renal diseases, at Cairo University Hospital, from June 2005 to Jan. Read More

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February 2019
17 Reads

Role of Steroids in Post-streptococcal Glomerulonephritis Without Crescents on Renal Biopsy.

Cureus 2018 Aug 15;10(8):e3150. Epub 2018 Aug 15.

Nephrology, Guthrie Clinic/Robert Packer Hospital, Sayre, USA.

Steroid is usually indicated in patients with post-streptococcal glomerulonephritis (PSGN) with more than 30% crescents on renal biopsy. The role of steroids in patients without crescentic glomerulonephritis is not clear. We present a 19-year-old male patient who was diagnosed with PSGN three weeks after a sore throat infection. Read More

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https://www.cureus.com/articles/14052-role-of-steroids-in-po
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http://dx.doi.org/10.7759/cureus.3150DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6191008PMC
August 2018
14 Reads

Histopathological Classification-A Prognostic Tool for Rapidly Progressive Glomerulonephritis.

Medicina (Kaunas) 2018 Apr 17;54(2). Epub 2018 Apr 17.

Centre of Nephrology, Vilnius University Hospital Santaros Klinikos, LT⁻08661 Vilnius, Lithuania.

Recently proposed histopathological classification may predict patient outcome in pauci-immune glomerulonephritis. This study sought to prove that the prognostic effect could be extended to all types of rapidly progressive glomerulonephritis. Retrospective analysis of patients diagnosed with rapidly progressive glomerulonephritis between April 1999 and August 2015 was performed. Read More

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http://www.mdpi.com/1648-9144/54/2/17
Publisher Site
http://dx.doi.org/10.3390/medicina54020017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6037248PMC
April 2018
11 Reads

Fibrillary Glomerulonephritis with Crescentic and Necrotizing Glomerulonephritis and Concurrent Thrombotic Microangiopathy.

Case Rep Nephrol Dial 2018 May-Aug;8(2):182-191. Epub 2018 Aug 31.

Regina General Hospital, Section of Nephrology, Department of Medicine, Regina, Saskatchewan, Canada.

We present a 77-year-old Caucasian woman who presented with nephrotic-range proteinuria, microhematuria, renal impairment, and extremely elevated blood pressure. She had a long history of well-controlled type 2 diabetes. Renal biopsy revealed fibrillary deposits in the mesangium and glomerular basement membrane consistent with fibrillary glomerulopathy (FGN), with crescentic changes and thrombotic microangiopathy (TMA). Read More

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http://dx.doi.org/10.1159/000492529DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6167697PMC
August 2018
15 Reads

Clinicopathological features and outcome of antibody-negative anti-glomerular basement membrane disease.

J Clin Pathol 2019 Jan 12;72(1):31-37. Epub 2018 Oct 12.

National Clinical Research Center of Kidney Diseases, Jinling Hospital, Nanjing University School of Medicine, Nanjing, China

Aim: To explore the clinicopathological characteristics of patients with anti-GBM antibody-negative anti-GBM disease.

Methods: The clinical and renal pathological findings were retrospectively studied in 19 patients. All patients met the following inclusion criteria: linear GBM IgG deposition on immunofluorescence(IF); and lack of serum anti-GBM antibodies by ELISA and indirect immunofluorescence assay. Read More

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http://jcp.bmj.com/lookup/doi/10.1136/jclinpath-2018-205278
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http://dx.doi.org/10.1136/jclinpath-2018-205278DOI Listing
January 2019
20 Reads
2.920 Impact Factor

Histopathological classification of anti-neutrophil cytoplasmic antibody-associated glomerulonephritis in a nationwide Japanese prospective 2-year follow-up cohort study.

Clin Exp Nephrol 2019 Mar 10;23(3):387-394. Epub 2018 Oct 10.

Department of Nephrology, Internal Medicine, Nagoya University Graduate School of Medicine, Aichi, Japan.

Background: The prognostic value of the EUVAS-proposed histopathological classification of anti-neutrophil cytoplasmic antibody (ANCA)-associated glomerulonephritis has been evaluated throughout the world. Here, we performed a Japanese nationwide biopsy survey to assess the association between this histopathological classification and renal prognosis after 2-year follow-up in ANCA-associated glomerulonephritis.

Methods: We collected 67 renal biopsy materials of the 321 entries in the RemIT-JAV-RPGN cohort study, and assessed their histologies. Read More

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http://dx.doi.org/10.1007/s10157-018-1656-1DOI Listing
March 2019
5 Reads

Clinical and pathologic characteristics of pauci-immune anti-myeloperoxidase antibody associated glomerulonephritis with nephrotic range proteinuria.

Ren Fail 2018 Nov;40(1):554-560

a Department of Nephrology , Tianjin Medical University General Hospital , Tianjin , China.

Background: Heavy proteinuria in antineutrophil cytoplasmic antibody (ANCA)-associated glomerulonephritis (GN) is usually considered to be associated with immune deposits in renal biopsy. Nephrotic ANCA GN without immune deposits (pauci-immune) is rare and has not been studied specially. In this study characteristics of these patients are to be investigated. Read More

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http://dx.doi.org/10.1080/0886022X.2018.1487865DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6171425PMC
November 2018
6 Reads
0.780 Impact Factor

Renal Involvement in Antineutrophil Cytoplasmic Antibody-Associated Vasculitis.

Rheum Dis Clin North Am 2018 11 7;44(4):525-543. Epub 2018 Sep 7.

Division of Nephrology, Vasculitis and Glomerulonephritis Center, Massachusetts General Hospital, 101 Merrimac Street, Boston, MA 02114, USA. Electronic address:

Antineutrophil cytoplasmic antibody-associated vasculitis (AAV) is the most common cause of rapidly progressive glomerulonephritis. ANCAs play an important role in the pathogenesis and diagnosis of AAV. The classic renal lesion in AAV is a pauci-immune necrotizing and crescentic glomerulonephritis. Read More

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http://dx.doi.org/10.1016/j.rdc.2018.06.001DOI Listing
November 2018
15 Reads