12,531 results match your criteria Glomerulonephritis Chronic


Causes of late transplant failure in cyclosporine-treated kidney allograft recipients.

Clin Exp Nephrol 2019 Apr 23. Epub 2019 Apr 23.

Renal Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.

Background: There is little information about very long-term outcomes of kidney allograft recipients exposed to calcineurin inhibitors.

Methods: In this single-centre retrospective study with 20-year follow-up, we analyzed data from 644 patients who underwent primary renal transplantation between 1983 and 1993. Participants were treated with a cyclosporine-based immunosuppressive scheme and had allograft function at 1 year. Read More

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http://link.springer.com/10.1007/s10157-019-01740-7
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http://dx.doi.org/10.1007/s10157-019-01740-7DOI Listing
April 2019
1 Read

A novel mutation in complement 2 accompanied by susceptibility variants in C3 glomerulonephritis: A case study.

Nefrologia 2019 Apr 20. Epub 2019 Apr 20.

Renal Division, Department of Medicine, Peking University First Hospital, Institute of Nephrology, Peking University, Beijing 100034, PR China; Key Laboratory of Renal Disease, Ministry of Health of China, Beijing 100034, PR China; Key Laboratory of CKD Prevention and Treatment, Ministry of Education of China, Beijing 100034, PR China; Peking-Tsinghua Center for Life Sciences, PR China.

Background: C3 glomerulonephritis is a rare, chronic disease characterized by C3c-dominant staining on renal biopsy and is caused by inherited or acquired alternative complement pathway dysregulation.

Case Presentation: Here, we reported a 36-year-old man presenting with nephritic syndrome and normal renal function. Secondary causes were excluded by detailed clinical history and laboratory tests. Read More

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http://dx.doi.org/10.1016/j.nefro.2019.01.008DOI Listing

Estimating the Change in Renal Function During the First Year of Therapy in ANCA-Associated Vasculitis.

Kidney Int Rep 2019 Apr 13;4(4):594-602. Epub 2019 Feb 13.

Nephrology Division, Hôpital du Sacré-Coeur de Montréal, Québec, Canada.

Introduction: Studies in antineutrophil cytoplasmic autoantibody (ANCA)-associated vasculitis (AAV) consistently show that the months following diagnosis have the greatest impact on the long-term renal function. Yet, it remains uncertain how much early gain should be expected with treatment. We sought to determine the factors associated with the change in glomerular filtration rate (GFR) throughout the first year. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S24680249193004
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http://dx.doi.org/10.1016/j.ekir.2019.02.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451086PMC
April 2019
2 Reads

Multiple Faces of Chronic Lymphocytic Leukaemia: A Patient with Renal, Cardiac, and Skeletal Complications.

Case Rep Nephrol 2019 12;2019:5390235. Epub 2019 Mar 12.

Department of Renal Medicine, Norfolk and Norwich University Hospital, Norwich, UK.

We describe a patient who had chronic lymphocytic leukaemia (CLL) Binet stage A at presentation with further evidence of disease at multiple sites but who initially required no treatment. However, several years later, her peripheral blood lymphocyte count started to increase, and soon after that she suffered an acute myocardial infarct (in the absence of coronary atheroma) together with proteinuric renal failure due to membranoproliferative glomerulonephritis. Her renal function improved markedly following anti-CLL chemotherapy. Read More

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https://www.hindawi.com/journals/crin/2019/5390235/
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http://dx.doi.org/10.1155/2019/5390235DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434293PMC
March 2019
2 Reads

Renal histopathology of prolonged acute kidney injury in HELLP syndrome: a case series and literature review.

Int Urol Nephrol 2019 Apr 15. Epub 2019 Apr 15.

Department of Nephrology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shuifuyuan 1, Wangfujing, Beijing, 100730, China.

Purpose: Acute kidney injury (AKI) is a severe complication of hemolysis, elevated liver enzymes, and low platelet count (HELLP) syndrome. However, renal pathological investigation of AKI in this syndrome has rarely been reported. We aimed to evaluate the renal pathological changes of persistent AKI and its relationship with renal outcomes in HELLP syndrome. Read More

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http://dx.doi.org/10.1007/s11255-019-02135-zDOI Listing
April 2019
1 Read

Mapping of Dynamic Transcriptome Changes Associated With Silica-Triggered Autoimmune Pathogenesis in the Lupus-Prone NZBWF1 Mouse.

Front Immunol 2019 29;10:632. Epub 2019 Mar 29.

Department of Food Science and Human Nutrition, Michigan State University, East Lansing, MI, United States.

Crystalline silica (cSiO) is a widely recognized environmental trigger of autoimmune disease. In the lupus-prone female NZBWF1 mouse, airway exposure to cSiO triggers pulmonary ectopic lymphoid neogenesis, systemic autoantibody elevation, and glomerulonephritis. Here we tested the hypothesis that upregulation of adaptive immune function genes in the lung precedes cSiO-triggering of autoimmune disease in this model. Read More

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https://www.frontiersin.org/article/10.3389/fimmu.2019.00632
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http://dx.doi.org/10.3389/fimmu.2019.00632DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6450439PMC
March 2019
2 Reads

Local miscommunications between glomerular cells as potential therapeutic targets for crescentic glomerulonephritides.

Nephrol Ther 2019 Apr;15 Suppl 1:S1-S5

Inserm, Paris Cardiovascular Centre (Parcc), 56, rue Leblanc, 75015 Paris, France; Université Paris Descartes, Sorbonne Paris Cité, 12, rue de l'École-de-Médecine, 75006 Paris, France. Electronic address:

Necrotizing and crescentic rapidly progressive glomerulonephritis or crescentic glomerulonephritis is one of the severest forms of acquired glomerular diseases with significant mortality. Risk of end-stage renal failure at 5 years is near 30%, with a number of patients developing chronic kidney disease. Currently, autoimmune crescentic glomerulonephritides are treated with broad-spectrum immunosuppression inducing remission of the injury in the majority of patients. Read More

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http://dx.doi.org/10.1016/j.nephro.2019.03.006DOI Listing
April 2019
1 Read

Is IgA Nephropathy Different in Different Ethnic Populations?

Nephrology (Carlton) 2019 Apr 11. Epub 2019 Apr 11.

Department of Infection, Immunity and Inflammation, University of Leicester, Leicester, United Kingdom.

IgA nephropathy (IgAN) is one of the commonest global patterns of primary glomerulonephritis and remains a leading cause of chronic kidney disease and end stage renal disease. The sole diagnostic criterion of IgAN remains the presence of dominant mesangial IgA deposits on kidney biopsy. Beyond this defining feature, there is significant heterogeneity in the epidemiology, clinical presentation, renal progression and long term outcomes of IgAN in different ethnic populations. Read More

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http://dx.doi.org/10.1111/nep.13592DOI Listing
April 2019
1 Read

Natural Killer Cells in Kidney Health and Disease.

Front Immunol 2019 26;10:587. Epub 2019 Mar 26.

Conjoint Kidney Research Laboratory, Chemical Pathology-Pathology Queensland, Brisbane, QLD, Australia.

Natural killer (NK) cells are a specialized population of innate lymphocytes that have a major effector function in local immune responses. While their immunological functions in many inflammatory diseases are well established, comparatively little is still known about their roles in kidney homeostasis and disease. Our understanding of kidney NK cells is rapidly evolving, with murine studies highlighting the functional significance of NK cells in acute and chronic forms of renal disease. Read More

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http://dx.doi.org/10.3389/fimmu.2019.00587DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443628PMC
March 2019
1 Read

[Preliminary study on the relationship between OSA and renal function].

Authors:
F Song H L Yi

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2019 Apr;33(4):298-303

Department of Otolaryngology Head and Neck Surgery,Shanghai Jiaotong University Affiliated Sixth People's Hospital,Otolaryngology Institute of Shanghai Jiaotong University, Shanghai, 200233, China.

To explore the relationship between obstructive sleep apnea(OSA) and renal function. We collected the clinical data of 487 patients who underwent sleep monitoring in our hospital from January 2013 to December 2017 and excluded history of chronic heart disease, acute and chronic glomerulonephritis, and pyelonephritis. Among the 487 patients, 54 were in nonOSA control group and 433 were in OSA group, including 64 patients with mild OSA, 77 patients with moderate OSA, 108 patients with severe OSA, and 188 patients with extremly severe OSA. Read More

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http://www.cnki.net/kcms/doi/10.13201/j.issn.1001-1781.2019.
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http://dx.doi.org/10.13201/j.issn.1001-1781.2019.04.004DOI Listing
April 2019
3 Reads

Clinical and histological features and therapeutic strategies for IgA nephropathy.

Clin Exp Nephrol 2019 Apr 9. Epub 2019 Apr 9.

Department of Nephrology, Tokyo Women's Medical University, 8-1 Kawada-cho, Shinjuku-ku, Tokyo, 162-8666, Japan.

Chronic glomerulonephritis is the second most common reason, after diabetic nephropathy, for initiation of dialysis in Japan and IgA nephropathy (IgAN) is the most prevalent form of chronic glomerulonephritis. In the half century since IgAN was initially reported, our understanding of the long-term prognosis, clinical and histological features, pathogenesis of onset and progression, risk factors for progression, and appropriate treatment under different clinical and histological conditions, has steadily increased. Strong experimental and clinical evidence, the Clinical Practice Guidelines for IgA Nephropathy in Japan, the Oxford Classification, and the Kidney Disease Improving Global Outcomes guidelines have all contributed to the appropriate treatment of IgAN. Read More

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http://dx.doi.org/10.1007/s10157-019-01735-4DOI Listing
April 2019
3 Reads

Quality of life among patients with moderate to advanced chronic kidney disease in Ghana - a single centre study.

BMC Nephrol 2019 Apr 8;20(1):122. Epub 2019 Apr 8.

Department of Medicine, Kwame Nkrumah University of Science and Technology, Kumasi, School of Medical Sciences, Kumasi, Ghana.

Background: The prevalence of chronic kidney disease (CKD) is increasing worldwide and in Africa. Health related quality of life (QOL) has become an essential outcome measure for patients with CKD and end stage renal disease (ESRD). There is growing interest worldwide in QOL of CKD patients but paucity of data in Ghana. Read More

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http://dx.doi.org/10.1186/s12882-019-1316-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454740PMC
April 2019
1 Read

Rapidly Progressive Glomerulonephritis Secondary to IgA Nephropathy in a Patient with Systemic Lupus Erythematosus.

Case Rep Nephrol 2019 5;2019:8354823. Epub 2019 Mar 5.

Department of Internal Medicine, Division of Nephrology, Houston, TX, USA.

Lupus nephritis is a common manifestation of systemic lupus erythematosus (SLE). IgA nephropathy is a common type of primary glomerulonephritis. Renal manifestations in SLE patients are often due to lupus nephritis; however, renal diseases unrelated to lupus nephritis are rarely reported. Read More

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https://www.hindawi.com/journals/crin/2019/8354823/
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http://dx.doi.org/10.1155/2019/8354823DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425374PMC
March 2019
4 Reads

TRPC channels: Regulation, dysregulation and contributions to chronic kidney disease.

Biochim Biophys Acta Mol Basis Dis 2019 Apr 4. Epub 2019 Apr 4.

Department of Biology and Biochemistry, University of Houston, Houston, TX, USA.

Mutations in the gene encoding canonical transient receptor potential-6 (TRPC6) channels result in severe nephrotic syndromes that typically lead to end-stage renal disease. Many but not all of these mutations result in a gain in the function of the resulting channel protein. Since those observations were first made, substantial work has supported the hypothesis that TRPC6 channels can also contribute to progression of acquired (non-genetic) glomerular diseases, including primary and secondary FSGS, glomerulosclerosis during autoimmune glomerulonephritis, and possibly in type-1 diabetes. Read More

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http://dx.doi.org/10.1016/j.bbadis.2019.04.001DOI Listing
April 2019
2 Reads

Kidney biopsy findings in children with sickle cell disease: a Midwest Pediatric Nephrology Consortium study.

Pediatr Nephrol 2019 Apr 3. Epub 2019 Apr 3.

Department of Pediatrics, Division of Nephrology, Emory University School of Medicine and Children's Healthcare of Atlanta, Atlanta, GA, USA.

Background: Renal damage is a progressive complication of sickle cell disease (SCD). Microalbuminuria is common in children with SCD, while a smaller number of children have more severe renal manifestations necessitating kidney biopsy. There is limited information on renal biopsy findings in children with SCD and subsequent management and outcome. Read More

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http://dx.doi.org/10.1007/s00467-019-04237-3DOI Listing
April 2019
3 Reads

The Emerging Role of Complement Proteins as a Target for Therapy of IgA Nephropathy.

Front Immunol 2019 19;10:504. Epub 2019 Mar 19.

Department of Pediatrics, University of Tennessee Health Sciences Center, Memphis, TN, United States.

IgA nephropathy (IgAN) is the most common form of primary glomerulonephritis worldwide and a common cause of end-stage renal disease. Evaluation of a kidney biopsy is necessary for diagnosis, with routine immunofluorescence microscopy revealing dominant or co-dominant IgA immunodeposits usually with complement C3 and sometimes IgG and/or IgM. IgA nephropathy reduces life expectancy by more than 10 years and leads to kidney failure in 20-40% of patients within 20 years of diagnosis. Read More

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http://dx.doi.org/10.3389/fimmu.2019.00504DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6433978PMC
March 2019
5 Reads

Membranous Nephropathy in a Patient with Human Immunodeficiency Virus Shortly After Initiation of HAART with Atripla.

Cureus 2019 Jan 21;11(1):e3932. Epub 2019 Jan 21.

Internal Medicine, Charleston Area Medical Center, Charleston, USA.

A human immunodeficiency virus (HIV) infection has long been associated with kidney disease. The pathogenesis of renal complications may be directly related to the presence of HIV viral particles or may occur secondary to an immune response against the virus. A number of HIV medications have been associated with the development of acute and chronic kidney disease. Read More

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http://dx.doi.org/10.7759/cureus.3932DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6430309PMC
January 2019
1 Read

Clinical Characteristics of Patients on Long-term Hemodialysis.

J Coll Physicians Surg Pak 2019 Apr;29(4):328-332

Department of Nephrology, The Kidney Centre Postgraduate Training Institute (TKC-PGTI), Karachi, Pakistan.

Objective: To study the clinical characteristics of patients on hemodialysis for more than ten years in order to highlight the modifiable factors that may improve survival in low socioeconomic status.

Study Design: Observational cross-sectional study.

Place And Duration Of Study: Department of Nephrology, The Kidney Centre Postgraduate Training Institute (TKCPGTI), Karachi, from November 2017 to January 2018. Read More

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http://dx.doi.org/10.29271/jcpsp.2019.04.328DOI Listing
April 2019
2 Reads

[Renal prognosis of IgA vasculitis nephritis in adult patients: a monocentric study of 25 cases].

Pan Afr Med J 2018 4;31. Epub 2018 Sep 4.

Service de Médecine Interne A, Hopital Charles Nicolle, Tunis, Tunisie.

IgA vasculitis nephritis affects the prognosis of this disease in adult patients. This study aimed to examine the clinical characteristics of this renal involvement in adults and to identify factors influencing renal prognosis. We conducted a retrospective monocentric study of patients with histologically confirmed IgA vasculitis nephritis (rheumatoid purpura) (EULAR classification criteria) with renal involvement classified according to Pillebout classification. Read More

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http://dx.doi.org/10.11604/pamj.2018.31.9.10594DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431421PMC
April 2019
1 Read

La ponction biopsie rénale: indications, complications et résultats.

Pan Afr Med J 2018 20;31:44. Epub 2018 Sep 20.

Centre Hospitalier Universitaire Mohammed VI, Oujda, Maroc.

Renal needle biopsy (RNB) is the gold standard in the diagnosis of kidney diseases. It is an invasive technique causing several complications, in particular hemorrhagic events. This study aims to evaluate our RNB practice, to update the current understanding of the technique for percutaneous renal biopsy, to assess complications and to determine the prevalence of kidney diseases diagnosed in our region. Read More

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http://dx.doi.org/10.11604/pamj.2018.31.44.15604DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6430949PMC
April 2019
1 Read

Prognostic factors in patients undergoing early-start peritoneal dialysis within 24 h after catheter insertion.

Braz J Med Biol Res 2019 Mar 25;52(3):e8055. Epub 2019 Mar 25.

Department of Nephrology, The Second Affiliated Hospital, Kunming Medical University, Kunming, Yunnan Province, China.

This study aimed to investigate the clinical characteristics, prognosis, and factors for survival of patients who underwent early-start peritoneal dialysis (PD) within 24 h after catheter insertion three years after PD. This study was conducted from January 1, 2013 to December 31, 2017. All adult patients who were diagnosed with end-stage renal disease (ESRD) and underwent PD for the first time within 24 h after catheter insertion in our hospital were included. Read More

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http://dx.doi.org/10.1590/1414-431X20188055DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437961PMC
March 2019
2 Reads
1.034 Impact Factor

Class IV Lupus Nephritis in the Setting of Serologically Quiescent Disease and Normal Urine Sediment in a Patient with Late-Onset Systemic Lupus Erythematosus.

Case Rep Rheumatol 2019 17;2019:1219529. Epub 2019 Feb 17.

Berkshire Medical Center, Pittsfield, MA, USA.

Systemic lupus erythematosus (SLE) is a chronic inflammatory autoimmune disease that may affect any organ of the body. Lupus nephritis (LN) is a frequent and serious complication of SLE. We report a case of an 80-year-old woman who was initially diagnosed with late-onset SLE and eventually developed LN in the setting of normal complements, double-stranded DNA, C-reactive protein, erythrocyte sedimentation rate, and urine sediment. Read More

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http://dx.doi.org/10.1155/2019/1219529DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6398080PMC
February 2019
1 Read

Differential contribution of C5aR and C5b-9 pathways to renal thrombic microangiopathy and macrovascular thrombosis in mice carrying an atypical hemolytic syndrome-related factor H mutation.

Kidney Int 2019 Feb 27. Epub 2019 Feb 27.

Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA. Electronic address:

Atypical hemolytic uremic syndrome (aHUS) is a form of thrombotic microangiopathy (TMA) caused by dysregulated complement activation. Clinically, aHUS is effectively treated by an anti-C5 monoclonal antibody (mAb) but whether the disease is mediated by the C5a receptor (C5aR) or C5b-9 pathway, or both, is unknown. Here we address this in a factor H mutant mouse (FH) which developed complement-mediated TMA as well as macrovascular thrombosis caused by an aHUS-related factor H point mutation (mouse W1206R, corresponding to human W1183R). Read More

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http://dx.doi.org/10.1016/j.kint.2019.01.009DOI Listing
February 2019
1 Read
8.563 Impact Factor

[H Factor Deficiency: A Case with an Atypical Presentation].

Acta Med Port 2019 Feb 28;32(2):158-161. Epub 2019 Feb 28.

Unidade de Imunodeficiências Primárias. Serviço de Pediatria. Hospital Dona Estefânia. Centro Hospitalar Lisboa Central. Lisboa. Chronic Diseases Research Center. NOVA Medical School. Lisboa. Portugal.

We report a case of an 18-month-old boy with H factor deficiency with atypical presentation: recurrent acute otitis media and several maternal family members with autoimmune disorders (vitiligo, thyroiditis and immune trombocytopenia). Blood tests revealed low C3 and AH50, as well as low properdin and H factor. I factor was normal. Read More

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https://www.actamedicaportuguesa.com/revista/index.php/amp/a
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http://dx.doi.org/10.20344/amp.10301DOI Listing
February 2019
5 Reads

Causes of Chronic Kidney Disease in Iranian Children: A Meta-Analysis and Systematic Review.

Ann Glob Health 2019 Mar 13;85(1). Epub 2019 Mar 13.

Nursing Department, Faculty of Nursing and Midwifery, Birjand University of Medical Sciences, Birjand, IR.

This study aimed to determine the causes of chronic kidney disease (CKD) in Iranian children. In this systematic review and meta-analysis study, international (PubMed, Web of Science, Scopus, and Google Scholar) and national (SID, Magiran) databases were searched for articles published through December 30, 2017. The quality of the studies was determined using the Hoy instrument. Read More

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http://dx.doi.org/10.5334/aogh.2391DOI Listing
March 2019
2 Reads

Circulating anti-phospholipase A2 receptor antibodies as a diagnostic and prognostic marker in Greek patients with idiopathic membranous nephropathy - a retrospective cohort study.

Rom J Intern Med 2018 Dec 1. Epub 2018 Dec 1.

Department of Nephrology, Hippokration General Hospital, Thessaloniki University School of Medicine, Thessaloniki, Greece.

Introduction: Circulating autoantibodies against phospholipase A2 receptor (anti-PLA2R) are recognized as key elements in the pathogenesis of idiopathic membranous nephropathy. In current clinical practice, they are increasingly gaining attention as novel tools for diagnosis and disease monitoring. We investigated the diagnostic and prognostic utility of anti-PLA2R antibody measurements in Greek patients with biopsy-proven membranous nephropathy. Read More

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http://content.sciendo.com/view/journals/rjim/ahead-of-print
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http://dx.doi.org/10.2478/rjim-2018-0044DOI Listing
December 2018
13 Reads

The pattern and outcomes of childhood renal diseases at University of Abuja Teaching Hospital, Abuja, Nigeria: A 4 year retrospective review.

Niger Postgrad Med J 2019 Jan-Mar;26(1):53-60

Nephrology Unit, Department of Paediatrics, University of Abuja Teaching Hospital, Gwagwalada, Abuja, Nigeria.

Introduction: Renal disorders contribute to childhood morbidity and mortality in developing countries. Therefore, the knowledge of the burden of childhood renal diseases is required for preventive and management purposes. This article determines the pattern and the outcomes of childhood renal diseases seen at the University of Abuja Teaching Hospital (UATH), Gwagwalada, Abuja, Nigeria. Read More

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http://dx.doi.org/10.4103/npmj.npmj_174_18DOI Listing
March 2019
1 Read

END-STAGE RENAL DISEASE PATIENTS WITH LOW SERUM ALBUMIN: IS PERITONEAL DIALYSIS AN OPTION?

Perit Dial Int 2019 Mar 9. Epub 2019 Mar 9.

Medicine, University of Wisconsin School fo Medicine and Public Health, Madison, United States.

Introduction: Low serum albumin is associated with high mortality in patients with end-stage renal disease (ESRD) on chronic dialysis. Clinicians are reluctant to offer peritoneal dialysis (PD) as an option for dialysis for patients with low serum albumin due to concerns of loss of albumin with PD, but evidence supporting differences in outcomes is limited. We evaluated mortality based on dialysis modality in patients with very low serum albumin (<2. Read More

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http://www.pdiconnect.com/lookup/doi/10.3747/pdi.2018.00204
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http://dx.doi.org/10.3747/pdi.2018.00204DOI Listing
March 2019
12 Reads

Dasatinib-induced nephrotic syndrome in a patient with chronic myelogenous leukemia: a case report.

BMC Nephrol 2019 Mar 7;20(1):87. Epub 2019 Mar 7.

Dialysis Division, University of Miyazaki Hospital, Miyazaki, Japan.

Background: Dasatinib is a second-generation tyrosine kinase inhibitor that is indicated for the treatment of patients with chronic myeloid leukemia. Here, we report the case of a man with nephrotic syndrome that was caused by dasatinib.

Case Presentation: A 40-year-old man with chronic myeloid leukemia was referred to our hospital because of proteinuria 1 month after dasatinib therapy was introduced. Read More

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http://dx.doi.org/10.1186/s12882-019-1273-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6407224PMC
March 2019
1 Read

End-stage renal disease secondary to anti-glomerular basement membrane disease in a child with common variable immunodeficiency.

Clin Nephrol Case Stud 2019 1;7:1-6. Epub 2019 Feb 1.

Division of Pediatric Nephrology, Department of Pediatrics.

Background: Anti-glomerular basement membrane (GBM) disease is caused by autoantibodies against the α3-chain of type IV collagen in the GBM. Common variable immunodeficiency (CVID) is a primary immunodeficiency manifested by hypogammaglobulinemia, inability to make functional antibody, and recurrent infections. This report extends the phenotype of CVID-associated autoimmune diseases to include anti-GBM disease. Read More

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http://dx.doi.org/10.5414/CNCS109510DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374989PMC
February 2019
2 Reads

A patent herbal drug Yi-Shen-Hua-Shi granule ameliorates C-BSA-induced chronic glomerulonephritis and inhabits TGFβ signaling in rats.

J Ethnopharmacol 2019 May 2;236:258-262. Epub 2019 Mar 2.

Research and Development Centre for Natural Health Products, HKBU Shenzhen Research and Continuing Education, Shenzhen, China; Consun Chinese Medicines Research Centre for Renal Diseases, Hong Kong Baptist University, Hong Kong, China. Electronic address:

Ethnopharmacology Relevance: Yi-Shen-Hua-Shi (YSHS) granule is a modern Chinese patent drug for treating chronic glomerulonephritis (CGN). It is derived from a traditional Chinese medicine formula Sheng-Yang-Yi-Wei decoction that is used to treat CGN in ancient China. Pharmacological activities of YSHS granule have not been reported. Read More

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http://dx.doi.org/10.1016/j.jep.2019.02.044DOI Listing
May 2019
6 Reads

Spectrum of biopsy proven renal disease in northern India: a single centre study.

Nephrology (Carlton) 2019 Mar 4. Epub 2019 Mar 4.

Department of Nephrology, All India Institute of Medical Sciences, New Delhi, India-110029.

Aim: Pattern of kidney diseases varies across geographies due to multiple factors. There is a paucity of information from South Asia due to absence of nationwide/regional biopsy registries. This study aimed to delineate the spectrum of renal parenchymal diseases in our region. Read More

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http://doi.wiley.com/10.1111/nep.13582
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http://dx.doi.org/10.1111/nep.13582DOI Listing
March 2019
14 Reads

Urinary miRNA profile for the diagnosis of IgA nephropathy.

BMC Nephrol 2019 Mar 4;20(1):77. Epub 2019 Mar 4.

Department of Medicine & Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, China.

Background: IgA nephropathy (IgAN) is the most common primary glomerulonephritis worldwide. Urinary micro-RNA (miRNA) level is increasingly reported to as non-invasive markers of various kidney diseases. We aim to identify urinary miRNA targets for the diagnosis of IgAN. Read More

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http://dx.doi.org/10.1186/s12882-019-1267-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6399975PMC
March 2019
2 Reads

Different histological classifications for Henoch-Schönlein purpura nephritis: which one should be used?

Pediatr Rheumatol Online J 2019 Feb 28;17(1):10. Epub 2019 Feb 28.

Department of Pediatrics, Hacettepe University, Ankara, Turkey.

Background: Nephritis is the most important chronic complication of IgA Vasculitis (IgAV)/Henoch-Schönlein purpura (IGAV/HSP) and thus the main prognostic factor of this most common childhood vasculitis. Since the prognosis and treatment selection depends on the mode of interpretation of biopsy material, in this manuscript we have presented several issues related to the uneven application of different histological classifications in IgAV/Henoch-Schönlein purpura nephritis (HSPN). The nephritis of IgAV/IGAV/HSP will be abbreviated as HSPN for this paper. Read More

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http://dx.doi.org/10.1186/s12969-019-0311-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6393980PMC
February 2019
1 Read

Hepatitis C virus-induced glomerular disease and posterior reversible encephalopathy syndrome after liver transplant: Case report and literature review.

Saudi J Kidney Dis Transpl 2019 Jan-Feb;30(1):239-249

Division of Nephrology, Maggiore Hospital and IRCCS Foundation; School of Medicine, University of Milano, Milano, Italy.

Chronic hepatitis C virus (HCV) infection is associated with numerous extra-hepatic complications, including neurological and renal manifestations. We describe the case of a 67-year-old Caucasian man with HCV-associated cryoglobulinemic glomerulonephritis, cirrhosis, and hepatocellular carcinoma. The early posttransplant course was complicated by fibrosing cholestatic hepatitis due to recurrent HCV in the graft (HCV RNA up to 44,944,438 IU/mL). Read More

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February 2019
2 Reads

IgA nephropathy: Missed diagnosis and renal transplant.

Saudi J Kidney Dis Transpl 2019 Jan-Feb;30(1):221-225

Department of Biochemistry, Faculty of Medicine, Umm Al-Qurra University, Mecca, Saudi Arabia.

The most common form of chronic glomerulonephritis worldwide is IgA nephropathy (IgAN) where IgA immune complexes are deposited in the glomeruli. About 40%-45% of patients with IgAN present with macroscopic hematuria. Diagnosis occurs through kidney biopsy to visualize IgA deposition in the glomerular mesangial area using immunofluorescence microscopy. Read More

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February 2019
11 Reads

NPHS2 gene sequencing results in children of the Azerbaijani population with different types of nephrotic syndrome caused by chronic glomerulonephritis.

Bratisl Lek Listy 2019;120(2):102-105

Objectives: The aim of the study was to determine the mutation of the podocin gene (NPHS2) in children with minimal changes diseases (steroid sensitive nephrotic syndrome (NS)) and steroid resistant NS.

Background: Despite the fact that the role of genetic factors is a well-known phenomenon, in NS there are still unknown aspects that are yet to be discovered. NS, type 2 is caused by NPHS2 gene and is characterised with proteinuria, minimal change disease on renal biopsy, poor response to steroid treatment, etc. Read More

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http://dx.doi.org/10.4149/BLL_2019_016DOI Listing
January 2019
1 Read

Video-assisted thoracic surgery for pleuroperitoneal communication.

Surg Case Rep 2019 Feb 19;5(1):34. Epub 2019 Feb 19.

Department of Thoracic Surgery, Tokyo Women's Medical University, 8-1 Kawada-cho, Shinjuku-ku, Tokyo, 162-8666, Japan.

Background: Hydrothorax due to pleuroperitoneal communication (PPC) is a rare complication of continuous ambulatory peritoneal dialysis (CAPD). Approximately 50% of the patients need to convert to hemodialysis.

Case Presentation: A 65-year-old man with chronic renal failure due to membranoproliferative glomerulonephritis underwent CAPD. Read More

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http://dx.doi.org/10.1186/s40792-019-0595-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381193PMC
February 2019
1 Read

Management of Chronic Active Antibody-Mediated Rejection in Renal Transplant Recipients: Single-Center Experience.

Exp Clin Transplant 2019 01;17(Suppl 1):113-119

From the Kuwait Ministry of Health, Hamed Al-Essa Organ Transplant Center, Sabah area, Kuwait.

Objectives: Data on the management of chronic antibody-mediated rejection after kidney transplantation are limited. We aimed to assess the impact of treatment of biopsy-proven chronic active antibodymediated rejection with combined plasma exchange, intravenous immunoglobulin, and rituximab treatment versus intravenous immunoglobulin alone or conservative management on the evolution of renal function in renal transplant recipients.

Materials And Methods: In this retrospective study, we compared patients diagnosed with chronic active antibody-mediated rejection who were treated with standard of care steroids, intravenous immunoglobulin, plasma exchange, and rituximab (n = 40) at our center versus those who received intravenous immunoglobulin only or just intensified maintenance immunosuppression (n = 28). Read More

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http://dx.doi.org/10.6002/ect.MESOT2018.O58DOI Listing
January 2019
2 Reads

Complete biopsy-proven resolution of deposits in recurrent proliferative glomerulonephritis with monoclonal IgG deposits (PGNMIGD) following rituximab treatment in renal allograft.

BMC Nephrol 2019 Feb 14;20(1):53. Epub 2019 Feb 14.

Department of Pathology, Division of Renal and Transplant Pathology, Ohio State University Wexner Medical Center, M018 Starling-Loving Hall, 320 W 10th Ave, Columbus, OH, 43210, USA.

Background: Proliferative glomerulonephritis with monoclonal IgG deposits (PGNMIGD) is a disease entity classified under the group of "Monoclonal gammopathy-related kidney diseases", and can recur after transplant. Clinical remission of proteinuria in patients with PGNMIGD has been previously shown following anti-B cell and/or anti-plasma cell therapies. Our case is the first to show complete histologic resolution of the glomerular monoclonal IgG kappa deposits in a case of recurrent PGNMIGD in renal allograft after rituximab and steroid treatment. Read More

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https://bmcnephrol.biomedcentral.com/articles/10.1186/s12882
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http://dx.doi.org/10.1186/s12882-019-1239-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6376770PMC
February 2019
7 Reads

Comparing outcomes of biopsy-proven anti-neutrophil cytoplasmic autoantibody-associated glomerulonephritis patients treated with cyclophosphamide in the 20th and 21st centuries: a 23-year study.

Clin Kidney J 2019 Feb 11;12(1):42-48. Epub 2018 Sep 11.

Renal Department, Royal Preston Hospital, Preston, UK.

Background: Anti-neutrophil cytoplasmic autoantibody (ANCA)-associated vasculitis (AAV) is a multisystem autoimmune disorder associated with significant morbidity and mortality. Approximately 80-90% of patients have circulating ANCAs. Long-term outcomes appear to be improving. Read More

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http://dx.doi.org/10.1093/ckj/sfy084DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366142PMC
February 2019
2 Reads

[Long-term results of chest wall arteriovenous graft for establishing hemodialysis access].

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 2019 02;33(2):227-231

Department of Vascular and Endovascular Surgery, Peking University First Hospital, Beijing, 100034, P.R.China.

Objective: To explore the role of chest wall arteriovenous graft (CWAVG) for establishing hemodialysis access in patients with end-stage renal disease.

Methods: A retrospective analysis was made on the clinical data of 12 patients with end-stage renal disease who underwent CWAVG for establishing hemodialysis access between January 2014 and June 2015. There were 3 males and 9 females with an average age of 63. Read More

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http://dx.doi.org/10.7507/1002-1892.201802003DOI Listing
February 2019
1 Read

[Essential mixed cryoglobulinemia type II: case report.]

Rev Fac Cien Med Univ Nac Cordoba 2018 11 13;75(4):292-298. Epub 2018 Nov 13.

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The cryoglobulinemic syndrome is produced by precipitating immunoglobulins at low temperatures. Its production is associated with several causes, such as lymphoproliferative disorders, chronic infections and autoimmune disorders. However, the etiology is unknow. Read More

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http://dx.doi.org/10.31053/1853.0605.v74.n3.17550DOI Listing
November 2018
3 Reads

Relationship of Remodeling of Carotid Arteries and Left Ventricular Geometry in Patients With Chronic Glomerulonephritis.

Kardiologiia 2018 Nov 18;58(4):45-52. Epub 2018 Nov 18.

Кыргызская государственная медицинская академия им. И. К. Ахунбаева; Кыргызско-Российский Славянский университет им. первого Президента России Б. Н. Ельцина.

Purpose: to study clinical-functional features of remodeling of carotid arteries and its relation to restructuring of the left ventricle (LV) in patients with chronic glomerulonephritis at pre-dialysis stage.

Materials And Methods: We examined 269 patients (189 men, 80 women) with chronic glomerulonephritis (CGN) aged 17-71 years, at pre-dialysis stages of the disease. We analyzed biochemical parameters of peripheral blood with the determination of daily proteinuria and glomerular filtration rate (GFR). Read More

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http://dx.doi.org/10.18087/cardio.2018.4.10108DOI Listing
November 2018
3 Reads

The role of podocytes dysfunction in chronic glomerulonephritis progression.

Ter Arkh 2018 Jun;90(6):92-97

I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of Russia, Moscow, Russia.

In the review, the mechanisms of podocytes damage underlying the development of proteinuria and progression of glomerulosclerosis in chronic glomerulonephritis are discussed in detail. The results of experimental and clinical studies are presented. Under the different immune and non-immune factors the podocytes form a stereotyped response to damage consisting in the reorganization of the actin cytoskeleton, foot process effacement, the detachment of podocytes from the glomerular basement membrane, and the appearance of specific podocyte proteins and whole cells (podocyturia) in the urine. Read More

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http://ter-arkhiv.ru/en/archive/2018/vol-90-6-2018/14_2730/?
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http://dx.doi.org/10.26442/terarkh201890692-97DOI Listing
June 2018
10 Reads

Relationship between serologic profile (ANCA type) and clinical features of renal involvement in ANCA-associated vasculitides.

Ter Arkh 2018 Jun;90(6):15-21

I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenov University), Moscow, Russia.

Aim: To compare the frequency, clinical features and outcomes of renal involvement in ANCA-associated vasculitides (AAV) in patients with antibodies against proteinase-3 (pr3-ANCA) and myeloperoxidase (MPO-ANCA).

Materials And Methods: In our retrospective study we enrolled 264 patients, 94 males and 170 females, median age 53 [36; 62] years. Among them 157 were pr3-ANCA positive and 107 were MPO-ANCA positive. Read More

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http://dx.doi.org/10.26442/terarkh201890615-21DOI Listing
June 2018
2 Reads

Anemia and Iron Deficiency in Children with Chronic Kidney Disease (CKD): Data from the Know-Ped CKD Study.

J Clin Med 2019 Jan 29;8(2). Epub 2019 Jan 29.

Department of Pediatrics, Yonsei University College of Medicine, Yonsei-ro 50, Seodaemun-gu, C.P.O. Box 8044, Seoul 03722, Korea.

Children with chronic kidney disease (CKD) are at high risk of anemia, an important risk factor for cardiovascular disease and poor quality of life. The present study used baseline data from the Korean cohort study for Outcome in patients With Pediatric Chronic Kidney Disease (KNOW-PedCKD). A Total of 437 patients was included in the analyses excluding missing data. Read More

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http://dx.doi.org/10.3390/jcm8020152DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6406575PMC
January 2019
10 Reads

A rare diagnosis of primary native kidney non-hodgkin's lymphoma after kidney transplantation.

Nephrology (Carlton) 2019 Feb;24(2):272

Renal Unit, Department of Medicine, Queen Elizabeth Hospital, Kowloon, Hong Kong SAR.

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http://dx.doi.org/10.1111/nep.13426DOI Listing
February 2019
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Maintenance therapy for lupus nephritis with mycophenolate mofetil or azathioprine. A meta-analysis
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Clin Nephrol 2019 Mar;91(3):172-179

Aim: Maintenance therapy for lupus nephritis (LN) remains controversial. This meta-analysis of randomized controlled trials (RCTs) describes the comparative benefits and safety of mycophenolate mofetil (MMF) versus azathioprine (AZA) as maintenance therapy in patients with LN.

Materials And Methods: RCTs that compared the maintenance regimens of MMF and AZA in the treatment of LN were included. Read More

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http://dx.doi.org/10.5414/CN109450DOI Listing
March 2019
3 Reads