13,015 results match your criteria Glomerulonephritis Chronic


Erectile dysfunction pre and post kidney transplant recipients in Duhok city; cross sectional study.

Ann Med Surg (Lond) 2020 Jul 16;55:107-110. Epub 2020 May 16.

Urologist, Duhok Directorate General of Health, Kurdistan Region, Iraq.

Introduction: Sexual dysfunction is a common problem in patients with chronic kidney disease. Disturbances in sexual function are noticed in early stages of chronic kidney diseases and deteriorate further as renal function declines. This is due to uremic effects, comorbid illness, anemia, hormonal disturbances, autonomic neuropathy, vascular diseases, hyperparathyroidism, hyperprolactinemia, side effects of medications, and psychosocial factors. Read More

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http://dx.doi.org/10.1016/j.amsu.2020.04.038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7251300PMC

Application of explainable ensemble artificial intelligence model to categorization of hemodialysis-patient and treatment using nationwide-real-world data in Japan.

PLoS One 2020 29;15(5):e0233491. Epub 2020 May 29.

Department of Nephrology, Tokyo Women's Medical University, Shinjuku, Tokyo, Japan.

Background: Although dialysis patients are at a high risk of death, it is difficult for medical practitioners to simultaneously evaluate many inter-related risk factors. In this study, we evaluated the characteristics of hemodialysis patients using machine learning model, and its usefulness for screening hemodialysis patients at a high risk of one-year death using the nation-wide database of the Japanese Society for Dialysis Therapy.

Materials And Methods: The patients were separated into two datasets (n = 39,930, 39,930, respectively). Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0233491PLOS

The immunological background of glomerular injuries

Orv Hetil 2020 06;161(24):993-1001

Gyermekgyógyászati és Nephrologiai Kutatócsoport,MTA-SE Budapest.

The basic structural units of the renal filtration are the glomeruli, which, in addition to their passive hemodynamic function, also participate in complex immune-mediated mechanisms. The immune system as a double-edged sword maintains the physiological homeostasis of the glomeruli, but also plays a crucial role in the induction of glomerular damage. The immune-mediated chronic glomerular injures are the most common cause of end-stage renal diseases. Read More

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http://dx.doi.org/10.1556/650.2020.31751DOI Listing

Primary antiphospholipid syndrome associated with anti-phospholipase A2 receptor antibody-positive membranous nephropathy.

BMC Nephrol 2020 May 24;21(1):196. Epub 2020 May 24.

Nephrology, dialysis and apheresis unit, University of Montpellier-Nimes, CHU de Nîmes, Rue du Professeur Robert Debré, Nîmes, France.

Background: The kidney is a major target in primary antiphospholipid syndrome. Several types of nephropathy have been reported, the most frequent being acute or chronic specific vascular nephropathies and membranous nephropathy.

Case Presentation: A 59-year-old male presented in our unit with nephrotic syndrome. Read More

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http://dx.doi.org/10.1186/s12882-020-01856-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7247250PMC

Clinical and histological differences between adults and children in new onset IgA nephropathy.

Pediatr Nephrol 2020 May 22. Epub 2020 May 22.

Centre de néphrologie et transplantation rénale, APHM, Hôpital Universitaire de la Conception, 147 Bd Baille, 13385, Marseille, France.

Background: Previous reports suggest initial presentation of IgA nephropathy (IgAN) in children is different from adults. No systematic comparison of clinical, biological, and histological childhood- and adult-onset IgAN is currently available.

Methods: We compared pediatric and adult clinical and histological characteristics at IgAN diagnosis. Read More

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http://dx.doi.org/10.1007/s00467-020-04614-3DOI Listing

Rituximab in severe immunoglobulin-A vasculitis (Henoch-Schönlein) with aggressive nephritis.

Clin Exp Rheumatol 2020 Mar-Apr;38 Suppl 124(2):195-200. Epub 2020 May 22.

CMID-Nephrology and Dialysis Unit, Center of Research of Rheumatologic, Nephrologic and Rare Diseases, and Coordinating Centre of the Network for Rare Diseases of Piedmont and Aosta Valley, San Giovanni Bosco Hospital and University of Turin, Italy.

Objectives: Immunoglobulin-A vasculitis (IgAV) is a systemic small-vessel vasculitis in which renal involvement indicates severity of illness, and chronic kidney disease represents the most serious long-term complication. No treatment at present is specifically recommended for IgAV. Recently, rituximab (RTX) has been shown to be effective in case series of adults with IgAV. Read More

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Eosinophilic fasciitis associated with generalized morphea and IgA nephropathy.

Dermatol Ther 2020 May 22:e13641. Epub 2020 May 22.

Department of Rheumatology,PLA General Hospital, Beijing, China.

Eosinophilic fasciitis (EF) is a rare connective tissue disease characterized by increased peripheral blood eosinophils and diffuse fasciitis, generalized morphea (GM) is a subtype of localized scleroderma, and IgA nephropathy is a chronic glomerulonephritis caused by abnormal deposition of IgA in the mesangial area of the glomeruli. We describe a 49-year-old male patient with hard skin, cutaneous hyperpigmentation, and proteinuria. The patient had suffered from a long disease course of hard skin, while urine protein was newly detected. Read More

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http://dx.doi.org/10.1111/dth.13641DOI Listing

Ion-Channel modulator TH1177 reduces glomerular injury and serum creatinine in chronic mesangial proliferative disease in rats.

BMC Nephrol 2020 May 19;21(1):187. Epub 2020 May 19.

Renal Sciences, Department of Inflammation Biology, King's College London, Renal Medicine 10 Cutcombe Road, London, SE5 9RJ, UK.

Background: T-type calcium channels (TTCC) are involved in mesangial cell proliferation. In acute thy-1 nephritis in the rat TTCC inhibition reduces glomerular damage and cell proliferation. This work is extended here by a study of the non-selective TTCC inhibitor TH1177 in a chronic model of proliferative glomerulonephritis (GN) including late treatment starting after the initial inflammation has resolved. Read More

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http://dx.doi.org/10.1186/s12882-020-01842-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7236127PMC

Glomerulonephritis Histopathological Pattern Change.

BMC Nephrol 2020 May 18;21(1):186. Epub 2020 May 18.

Mubarak Al-Kabeer Hospital, Department of Internal Medicine, Nephrology Unit, Jabriya, Kuwait.

Background: Glomerulonephritides (GN) are relatively rare kidney diseases with substantial morbidity and mortality. They are often difficult to treat, sometimes with no cure, and can lead to chronic kidney disease (CKD) and end stage kidney disease (ESKD). Kidney biopsy is the diagnostic procedure of choice with variable indications from center to center. Read More

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http://dx.doi.org/10.1186/s12882-020-01836-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7236312PMC

IgA nephropathy associated with thalassemia: a case report.

BMC Nephrol 2020 May 14;21(1):182. Epub 2020 May 14.

The Department of Nephrology (Key laboratory of management of kidney disease in Zhejiang province), Hangzhou Hospital of Traditional Chinese Medicine, Hangzhou, Zhejiang, P. R. China.

Background: Thalassemia is a group of hereditary diseases characterized by a common recessive monogenic hematological disorder, presenting a significant public health concern in the developing countries. Recent studies have identified the renal effects of thalassemia syndrome. Chronic hypoxia, long-term anemia, iron overload, and iron chelators are the major causes of renal tubular dysfunction and glomerular filtration abnormalities, while glomerulonephritis is not considered a major cause of abnormal urinalysis. Read More

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http://dx.doi.org/10.1186/s12882-020-01844-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7227039PMC

Clinical course of Immunoglobulin A nephropathy with Crescents in a multi-ethnic Southeast Asian cohort.

Nephrology (Carlton) 2020 May 13. Epub 2020 May 13.

Department of Renal Medicine, Singapore General Hospital.

Introduction: Clinical presentation and course of Immunoglobulin A nephropathy vary by ethnicity and geography and significance of extracapillary proliferation or crescents (IgAN-C) in Southeast Asia is not well described. We aimed to describe the clinical course of IgAN-C in Singapore.

Methods: Retrospective cohort study of adult biopsy-proven IgAN diagnosed between February 2011 and October 2016 in 2 hospital-based nephrology units. Read More

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http://dx.doi.org/10.1111/nep.13723DOI Listing

Kidney dendritic cells: fundamental biology and functional roles in health and disease.

Nat Rev Nephrol 2020 May 5. Epub 2020 May 5.

Division of Translational Immunology, III Medizinische Klinik, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany.

Dendritic cells (DCs) are chief inducers of adaptive immunity and regulate local inflammatory responses across the body. Together with macrophages, the other main type of mononuclear phagocyte, DCs constitute the most abundant component of the intrarenal immune system. This network of functionally specialized immune cells constantly surveys its microenvironment for signs of injury or infection, which trigger the initiation of an immune response. Read More

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http://dx.doi.org/10.1038/s41581-020-0272-yDOI Listing

The telomerase gene polymorphisms, but not telomere length, increase susceptibility to primary glomerulonephritis/end stage renal diseases in females.

J Transl Med 2020 May 4;18(1):184. Epub 2020 May 4.

Department of Medicine, Center for Molecular Medicine and Bioclinicum, Karolinska Institutet, Karolinska University Hospital Solna, SE-171 76, Stockholm, Sweden.

Background: Primary glomerulonephritis (GN) is the leading cause of chronic kidney disease (CKD) and frequently progresses into end stage renal diseases (ESRDs). Shorter leukocyte telomere length (LTL) has been implicated in the CKD susceptibility and diminished kidney function, however, it is unclear whether the variants in telomerase genes contribute to risk to GN/CKD/ESRD. Here we address this issue by determining their association with the genetic variants of rs12696304 at the telomerase RNA component (TERC) and rs2736100 at the telomerase reverse transcriptase (TERT) loci. Read More

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http://dx.doi.org/10.1186/s12967-020-02347-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7199377PMC
May 2020
3.930 Impact Factor

[Features of chronic kidney disease in elderly patients.]

Authors:
O N Kurochkina

Adv Gerontol 2020 ;33(1):113-120

Pitirim Sorokin Syktyvkar State University, 55 Oktyabrsky pr., Syktyvkar 557001, Komi Republic, Russian Federation, e-mail:

The purpose of the work is to study the characteristics of the course of chronic kidney disease in elderly patients based on the analysis of the register of chronic kidney disease (CKD) for 2015-2018. in the Department of Nephrology, the Komi Republican Clinical Hospital. There are 484 patients in the register, of whom 231 are men (47,7%), 253 women (52,3%). Read More

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January 2020

Pregnant woman with primary membranous nephropathy - case report.

Pol Merkur Lekarski 2020 Apr;48(284):105-107

Department of Transplantation Medicine, Nephrology and Internal Medicine, Medical University of Warsaw.

Membranous nephropathy is a common form of glomerulonephritis typically presenting between 30 to 50 years of age with nephrotic range proteinuria, with one third of patients undergoing spontaneous remission, one third experiencing non-progressive CKD (Chronic Kidney Disease) while the remaining third progressing to ESRD (end stage renal disease).

Case Report: A 21-year old pregnant female developed massive proteinuria and hypoalbuminemia during first weeks of pregnancy and required intensive nephrological evaluation and treatment. Renal biopsy was performed, microscopic examination was consistent with Membranous Nephropathy and as anti-PLA2R antibodies tested positive, active disease was confirmed. Read More

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Coxsackievirus B4 Exposure Results in Variable Pattern Recognition Response in the Kidneys of Female Non-obese Diabetic Mice Before Establishment of Diabetes.

Viral Immunol 2020 Apr 29. Epub 2020 Apr 29.

Interdisciplinary Program in Molecular and Cellular Biology, Ohio University, Athens, Ohio, USA.

End-stage renal disease (ESRD) is described by four primary diagnoses, diabetes, hypertension, glomerulonephritis, and cystic kidney disease, all of which have viruses implicated as causative agents. Enteroviruses, such as coxsackievirus (CV), are a common genus of viruses that have been implicated in both diabetes and cystic kidney disease; however, little is known about how CVs cause kidney injury and ESRD or predispose individuals with a genetic susceptibility to type 1 diabetes (T1D) to kidney injury. This study evaluated kidney injury resulting from coxsackievirus B4 (CVB4) inoculation of non-obese diabetic (NOD) mice to glean a better understanding of how viral exposure may predispose individuals with a genetic susceptibility to T1D to kidney injury. Read More

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http://dx.doi.org/10.1089/vim.2019.0188DOI Listing

IgA vasculitis and anti-GBM disease: two ends of a spectrum of immune complex vasculitis.

Authors:
Alan D Salama

Rheumatology (Oxford) 2020 May;59(Supplement_3):iii118-iii122

UCL Department of Renal Medicine, Royal Free Hospital, London, UK.

Two immune complex vasculitides, IgA vasculitis (IgAV) and anti-GBM disease, represent polar extremes with regard to our understanding of disease pathogenesis, standardized management protocols and outcomes. This report compares our current approach to these uncommon entities in adults. Both diseases demonstrate degrees of small vessel necrosis and glomerular crescent formation. Read More

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http://dx.doi.org/10.1093/rheumatology/kez540DOI Listing

Recent Advances in Pathology: the 2020 Annual Review Issue of The Journal of Pathology.

J Pathol 2020 Apr;250(5):475-479

RECAMO, Masaryk Memorial Cancer Institute, Brno, Czech Republic.

This year's Annual Review Issue of The Journal of Pathology contains 18 invited reviews on current research areas in pathology. The subject areas reflect the broad range of topics covered by the journal and this year encompass the development and application of software in digital histopathology, implementation of biomarkers in pathology practice; genetics and epigenetics, and stromal influences in disease. The reviews are authored by experts in their field and provide comprehensive updates in the chosen areas, in which there has been considerable recent progress in our understanding of disease. Read More

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http://dx.doi.org/10.1002/path.5425DOI Listing

Mechanism of Chronic Kidney Disease Progression and Novel Biomarkers: A Metabolomic Analysis of Experimental Glomerulonephritis.

Metabolites 2020 Apr 24;10(4). Epub 2020 Apr 24.

Kidney Research Institute, Seoul National University College of Medicine, Seoul 03080, Korea.

While a complex network of cellular and molecular events is known to be involved in the pathophysiological mechanism of chronic kidney disease (CKD), the divergence point between reversal and progression and the event that triggers CKD progression are still unknown. To understand the different mechanisms between reversible and irreversible kidney disease and to search for urinary biomarkers that can predict prognosis, a metabolomic analysis was applied to compare acute and chronic experimental glomerulonephritis (GN) models. Four metabolites, namely, epoxyoctadecenoic acid (EpOME), epoxyeicosatetraenoic acid (EpETE), α-linolenic acid (ALA), and hydroxyretinoic acid, were identified as predictive markers after comparing the chronic nephritis model with acute nephritis and control groups (false discovery rate adjusted -value (q-value) < 0. Read More

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http://dx.doi.org/10.3390/metabo10040169DOI Listing

[Changes of urinary monocyte chemotactic protein 1 and epidermal growth factor and their correlations with clinicopathology in idiopathic membranous nephropathy patients].

Zhonghua Yi Xue Za Zhi 2020 Apr;100(16):1230-1234

Department of Nephrology, the First Affiliated Hospital of Zhengzhou University, Research Institute of Nephrology, Zhengzhou University, Key Laboratory of Precision Diagnosis and Treatment for Chronic Kidney Disease in Henan Province, Zhengzhou 450052, China.

To explore the changes and clinical value of urinary monocyte chemotactic protein 1 (MCP-1), epidermal growth factor (EGF) and their ratio in patients with idiopathic membranous nephropathy (IMN). A total of 67 IMN patients were enrolled according to kidney biopsy in the Department of Nephrology of the First Affiliated Hospital of Zhengzhou University from January 2017 to December 2018. The patients included 28 males and 39 females, with an average age of (47. Read More

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http://dx.doi.org/10.3760/cma.j.cn112137-20191205-02656DOI Listing

Cryptococcosis in an HIV-negative, HCV positive, immunosenescent patient: a case report.

New Microbiol 2019 Dec 13;43(1). Epub 2019 Dec 13.

Microbiology and Virology Unit, IRCCS San Matteo Hospital Foundation, Pavia, Italy.

Cryptococcus species is still a very common opportunistic infection in AIDS patients. However, it is increasingly responsible for disease in otherwise immunocompromised individuals, such as transplant recipients and the heterogeneous group of patients with underlying immunologic diseases, hematologic disorders and organ failure syndromes. Clinical presentation, prognosis, and outcomes are difficult to define given these varied host groups, and tailoring treatments to fit the necessities of each patient is likewise challenging. Read More

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December 2019

Spectrum and Clinical Characteristics of Renal Diseases in Ghanaian Adults: A 13-Year Retrospective Study.

Int J Nephrol 2020 13;2020:8967258. Epub 2020 Apr 13.

Department of Medical Laboratory Science, School of Allied Health Sciences, University of Health and Allied Sciences, Ho, Ghana.

Background: Renal diseases over the years have become one of the leading causes of morbidity and mortality worldwide. In this study, we assessed the spectrum and clinical characteristics of Ghanaians with renal diseases at the nephrology unit of Komfo Anokye Teaching Hospital (KATH), Kumasi.

Methods: This was a retrospective hospital-based study conducted at Komfo Anokye Teaching Hospital (KATH) from the years 2005 to 2017. Read More

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http://dx.doi.org/10.1155/2020/8967258DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7174960PMC

Severe vaso-occlusive lupus retinopathy in the early stage of a pediatric patient with systemic lupus erythematosus: a case report.

Medicine (Baltimore) 2020 Apr;99(16):e19875

Introduction: Systemic lupus erythematosus (SLE) is a multisystem, chronic, autoimmune disease which can affect any organ system including the eye. About one-third of the patients can be diagnosed with SLE-related eye involvement which is usually indicative of disease activity. Retinopathy is one of the most vision-threatening complications that can be associated with the disease. Read More

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http://dx.doi.org/10.1097/MD.0000000000019875DOI Listing

Renal Toxicity.

Adv Exp Med Biol 2020 ;1244:287-293

Division of Internal Medicine, Section of Nephrology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

With the increasing use of immunotherapy, there has been an associated increased survival in many cancers but has also resulted in unregulated organ-specific toxicities. In this chapter, we discuss the renal toxicities associated with a checkpoint inhibitor (CPI) from the typical acute tubulointersitial nephritis to glomerulonephritis, their proposed mechanisms, and treatments. We also discuss the use of CPI and reactivation of preexisting auto-immune diseases and focus on renal cell cancer in setting of Chronic kidney disease (CKD). Read More

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http://dx.doi.org/10.1007/978-3-030-41008-7_16DOI Listing
January 2020

Complement activation is associated with crescent formation in IgA nephropathy.

Virchows Arch 2020 Apr 16. Epub 2020 Apr 16.

Department of Diagnostic Pathology, Nara Medical University, 840 Shijo-Cho, Kashihara, Nara, Japan.

IgA nephropathy (IgAN) is common chronic glomerulonephritis with variable prognosis, ranging from minor urinary abnormalities to end-stage renal disease. The revised Oxford classification of IgAN explains that cellular/fibrocellular crescents are associated with poor renal prognosis, proposing an extension to the MEST-C score. C3 immunofluorescent staining follows a distribution similar to IgA staining. Read More

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http://dx.doi.org/10.1007/s00428-020-02800-0DOI Listing

An Uncommon Concurrence of Cytomegalovirus Retinitis and Corneal Endotheliitis in an Immunocompromised HIV-Negative Patient.

Ocul Immunol Inflamm 2020 Apr 10:1-3. Epub 2020 Apr 10.

Department of Ophthalmology, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.

: To describe a case of Cytomegalovirus (CMV) retinitis in both eyes complicated with unilateral corneal endotheliitis in an iatrogenic immunocompromised patient.: A retrospective case report.: A 58-year-old male, on long-term immunosuppressive treatment for chronic glomerulonephritis and nephrotic syndrome. Read More

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http://dx.doi.org/10.1080/09273948.2019.1695859DOI Listing

The Effect of Low-Power Laser Therapy on the TGF/β Signaling Pathway in Chronic Kidney Disease: A Review.

J Lasers Med Sci 2020 15;11(2):220-225. Epub 2020 Mar 15.

Laser Application in Medical Sciences Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

The purpose of this study is to investigate the effects of low-power lasers on kidney disease by investigating several studies. A number of articles from 1998 to 2019 were chosen from the sources of PubMed, Scopus, and only the articles studying the effect of low-power lasers on kidney disease were investigated. After reviewing the literature, 21 articles examining only the effects of low-power lasers on kidney disease were found. Read More

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http://dx.doi.org/10.34172/jlms.2020.36DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7118498PMC

Heat shock protein 90 and NFkB levels in serum and urine in patients with chronic glomerulonephritis.

Cell Stress Chaperones 2020 May 2;25(3):495-501. Epub 2020 Apr 2.

Tareev Clinic of Internal Diseases, Sechenov First Moscow State Medical University, Rossolimo 11/5, Moscow, Russia, 119435.

Heat shock proteins play an important role in immune inflammation and the formation and restoration of proteins. In recent years, the importance of heat shock protein 90 (Hsp90) in the activation of immune inflammation through nuclear factor kB (NFkB) has been discussed. To assess the activation of the Hsp90-NFkB system by measuring serum and urinary levels in patients with chronic glomerulonephritis (CGN). Read More

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http://dx.doi.org/10.1007/s12192-020-01089-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7193002PMC

Eosinophilic peritonitis induced by sucroferric oxyhydroxide.

Perit Dial Int 2020 Mar 27:896860820915019. Epub 2020 Mar 27.

Division of Nephrology, First Department of Integrated Medicine, Saitama Medical Center, Jichi Medical University, Japan.

A 49-year-old woman developed eosinophilic peritonitis 2 months after starting continuous ambulatory peritoneal dialysis because of congenital right kidney hypoplasia and chronic glomerulonephritis. This was shown to have been induced by sucroferric oxyhydroxide, an iron-based phosphate binder, using a drug-induced lymphocyte stimulation test. Her eosinophilic peritonitis was improved after stopping the administration of sucroferric oxyhydroxide without providing any immunosuppressive agents. Read More

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http://dx.doi.org/10.1177/0896860820915019DOI Listing

Persistent nonregenerative anemia in a 4-year-old cat.

Vet Clin Pathol 2020 Mar 22;49(1):11-16. Epub 2020 Mar 22.

Department of Veterinary Biosciences, The Ohio State University College of Veterinary Medicine, Columbus, OH, USA.

A 4-year-old male neutered domestic shorthair cat was presented to The Ohio State University College of Veterinary Medicine for a 2-month history of severe weight loss, lethargy, anemia, and bilaterally hyperechoic kidneys with loss of corticomedullary distinction as reported by the referring veterinarian. Relevant initial laboratory results included severe non-regenerative normocytic hypochromic anemia, increased blood urea nitrogen, minimally concentrated urine, proteinuria, and an increased urine protein:creatinine ratio. Cytologic evaluation of a bone marrow aspirate revealed a markedly hypocellular marrow with abundant mucinous material. Read More

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http://dx.doi.org/10.1111/vcp.12837DOI Listing

Preeclampsia and Glomerulonephritis: A Bidirectional Association.

Curr Hypertens Rep 2020 Mar 21;22(5):36. Epub 2020 Mar 21.

Nephrology, Dialysis and Transplantation Unit, Department of Emergency and Organ Transplantation, University of Bari Aldo Moro, Bari, Italy.

Purpose Of Review: We focus on the current understanding of preeclampsia (PE) in order to examine how it mediates glomerular injury and affects the course of glomerulonephritis (GNs). In addition, this review discusses the role of GNs on the development of PE.

Recent Findings: In PE, the dysfunctional utero-placental perfusion causes the release into the mother's circulation of anti-angiogenic substances, leading to systemic endotheliosis. Read More

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http://dx.doi.org/10.1007/s11906-020-1033-9DOI Listing

Trends in premature avertable mortality from non-communicable diseases for 195 countries and territories, 1990-2017: a population-based study.

Lancet Glob Health 2020 Apr;8(4):e511-e523

London School of Hygiene & Tropical Medicine, London, UK.

Background: The reduction by a third of premature non-communicable disease (NCD) mortality by 2030 is the ambitious target of Sustainable Development Goal (SDG) 3.4. However, the indicator is narrowly defined, including only four major NCDs (cardiovascular diseases, cancer, diabetes, and chronic respiratory diseases) and only for people aged 30-70 years. Read More

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http://dx.doi.org/10.1016/S2214-109X(20)30035-8DOI Listing

[Paradigm shift in understanding Acute kidney injury in patients with chronic liver disease: From pathophysiology to defining disease entities].

Z Gastroenterol 2020 Mar 20;58(3):254-266. Epub 2020 Mar 20.

Klinik für Nieren- und Hochdruckerkrankungen, Diabetologie und Endokrinologie, Medizinische Fakultät der Otto-von-Guericke-Universität, Magdeburg, Deutschland.

The hepatorenal syndrome (HRS) is only a part of the wide spectrum of renal injury in patients with end-stage liver cirrhosis. Besides that, the advanced liver disease itself, or its underlying causes, as well as comorbidities, like diabetes mellitus, adiposity and arterial hypertension, can directly cause parenchymal renal insults (bile acid nephropathy, ischemic tubular injury, diabetic/hypertensive nephropathy, hepatitis B- and C-associated glomerulonephritis etc.). Read More

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http://dx.doi.org/10.1055/a-1088-1582DOI Listing

Aetiology of chronic kidney disease and risk factors for disease progression in Chinese subjects: A single-centre retrospective study in Beijing.

Nephrology (Carlton) 2020 Mar 16. Epub 2020 Mar 16.

Department of Nephrology, Peking University People's Hospital, Beijing, China.

Aim: To assess the aetiological factors of chronic kidney disease (CKD) and factors associated with disease progression.

Methods: Single-centre retrospective study evaluating thorough electronic medical records of patients diagnosed with CKD at Peking University People's Hospital (April 2010-April 2015). The objectives were to identify the aetiological factors of CKD in Chinese patients and risk factors associated with CKD progression. Read More

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http://dx.doi.org/10.1111/nep.13714DOI Listing

Clinical Phenotypes and Long-term Prognosis in White Patients With Biopsy-Verified Hypertensive Nephrosclerosis.

Kidney Int Rep 2020 Mar 27;5(3):339-347. Epub 2019 Dec 27.

Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway.

Introduction: Hypertensive nephrosclerosis is considered the second most common cause of end-stage renal disease (ESRD), but it is still an insufficiently studied and controversial disease entity. More information on the phenotype and prognosis is needed to improve clinical diagnostics and treatment.

Methods: We included all Norwegian patients with chronic kidney disease (CKD) referred for kidney biopsy between 1988 and 2012 whose clinical presentation was consistent with, but not primarily suspicious for, hypertensive nephrosclerosis (n = 4920); follow-up continued until 2013. Read More

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http://dx.doi.org/10.1016/j.ekir.2019.12.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7056866PMC

Therapeutic Potential of Thrombomodulin in Renal Fibrosis of Nephrotoxic Serum Nephritis in Wistar-Kyoto Rats.

Kidney Blood Press Res 2020 6;45(3):391-406. Epub 2020 Mar 6.

Division of Nephrology, Department of Medicine, Showa University School of Medicine, Tokyo, Japan.

Background: Recombinant human soluble thrombomodulin (rhTM) was approved in 2008 and has been used for treatment of disseminated intravascular coagulation in Japan. The antifibrotic effects of rhTM in acute exacerbation of idiopathic pulmonary fibrosis are well established, but the therapeutic potential of rhTM in renal fibrosis remains poorly understood.

Methods: Nephrotoxic serum nephritis (NTS-N) was induced in 22 female Wistar-Kyoto (WKY) rats on day 0. Read More

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http://dx.doi.org/10.1159/000506286DOI Listing

Acute Kidney Injury Without Previous Renal Disease in Critical Care Unit.

Pediatr Int 2020 Mar 7. Epub 2020 Mar 7.

Division of Nephrology, Department of Pediatrics, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand.

Background: Acute kidney injury (AKI) is common in hospitalized and critically ill children. Apart from primary kidney disease, etiologies of AKI are usually related to systemic disease and nephrotoxic insult. This study examines an incidence, characteristics and mortality risks of AKI in critically ill children without primary renal disease and previously known chronic kidney disease (CKD). Read More

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http://dx.doi.org/10.1111/ped.14218DOI Listing

Curcumin Attenuates Both Acute and Chronic Immune Nephritis.

Int J Mol Sci 2020 Mar 4;21(5). Epub 2020 Mar 4.

Department of Biomedical Engineering, University of Houston, Houston, TX 77204, USA.

Curcumin is known to have immunomodulatory potential in addition to anti-oxidant, anti-inflammatory and anti-carcinogenic effects. The aim of the present study is to investigate the therapeutic effects of curcumin on immune-mediated renal disease in an anti-glomerular basement membrane (GBM) model (representing acute kidney Injury, AKI) and murine lupus model (representing chronic kidney disease, CKD). In the AKI model, female anti-GBM 129/svj mice were administered with curcumin right before disease induction. Read More

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http://dx.doi.org/10.3390/ijms21051745DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7084772PMC

Clinical Profile and Outcome of IgA Nephropathy from a Tertiary Care Hospital in North India.

J Assoc Physicians India 2020 Mar;68(3):20-22

Professor and Head, Departments of Nephrology, Indira Gandhi Medical College, Shimla, Himachal Pradesh; Corresponding Author.

Aim: To study the clinical profile and outcome of the patients with kidney biopsy diagnosis of IgA Nephropathy (IgAN).

Methods: A retrospective study of the patients diagnosed IgAN over a period of three and half years.

Results: Sixty (13. Read More

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Applying single-cell technologies to clinical pathology: progress in nephropathology.

J Pathol 2020 Apr 31;250(5):693-704. Epub 2020 Mar 31.

Department of Medicine, University of Cambridge, Cambridge, UK.

Cells represent the basic building blocks of living organisms. Accurate characterisation of cellular phenotype, intercellular signalling networks, and the spatial organisation of cells within organs is crucial to deliver a better understanding of the processes underpinning physiology, and the perturbations that lead to disease. Single-cell methodologies have increased rapidly in scale and scope in recent years and are set to generate important insights into human disease. Read More

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http://dx.doi.org/10.1002/path.5417DOI Listing

SPTB related spherocytosis in a three-generation family presenting with kidney failure in adulthood due to co-occurrence of UMOD disease causing variant.

Nefrologia 2020 Feb 26. Epub 2020 Feb 26.

University Medical Centre Ljubljana, University Children's Hospital, Institute for Special Laboratory Diagnostics, Ljubljana, Slovenia; University of Ljubljana, Faculty of Medicine, Institute of Biochemistry, Ljubljana, Slovenia. Electronic address:

Background: Hereditary spherocytosis is clinically and genetically heterogeneous disorder and its clinical characteristics are spherocytosis, anaemia, jaundice and splenomegaly. The aetiology is associated to the genes encoding proteins involved in the interaction between the erythrocyte membrane and the lipid bilayer. Causative variants in βI-spectrin (SPTB) gene presenting as mild to moderately severe disease are responsible for approximately 25% cases in the USA and Europe. Read More

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http://dx.doi.org/10.1016/j.nefro.2019.10.009DOI Listing
February 2020

Sex and Glomerular Filtration Rate Trajectories in Children.

Clin J Am Soc Nephrol 2020 Mar 28;15(3):320-329. Epub 2020 Feb 28.

Department of Pediatric Nephrology, Robert Debré Hospital, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France;

Background And Objectives: Differences in CKD progression by sex have been hypothesized to explain disparities in access to kidney transplantation in children. This study aims to identify distinct trajectories of eGFR decline and to investigate the association of sex with eGFR decline.

Design, Setting, Participants, & Measurements: We used data from the CKD in Children study. Read More

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http://dx.doi.org/10.2215/CJN.08420719DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7057295PMC

From Uganda to Italy: a case of nephrotic syndrome secondary to Plasmodium infection, Quartan malarial nephropathy and kidney failure.

Turk J Pediatr 2019 ;61(5):776-779

Pediatric Nephrology and Dialysis Unit, Pediatric Hospital Giovanni XXIII, Bari.

Gentile F, Martino M, Santangelo L, Giordano P, Torres DD, Carbone V, Di Palma AM, Rossini M, Gesualdo L, Giordano P, Giordano M. From Uganda to Italy: a case of nephrotic syndrome secondary to Plasmodium infection, Quartan malarial nephropathy and kidney failure. Turk J Pediatr 2019; 61: 776-779. Read More

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http://dx.doi.org/10.24953/turkjped.2019.05.019DOI Listing
January 2019

The Characteristics of Intestinal-Barrier Damage in Rats With IgA Nephropathy.

Am J Med Sci 2020 03 30;359(3):168-176. Epub 2019 Nov 30.

Department of Traditional Chinese Medicine, Beijing Children's Hospital, Capital Medical University, Beijing, China; National Center for Children's Health (Beijing), Beijing, China. Electronic address:

Background: Intestinal-barrier damage plays an important pathogenic role in immunoglobulin A nephropathy (IgAN). In this study, we explored the characteristics of the intestinal barrier in rats with IgAN.

Materials And Methods: We randomly divided 17 Sprague Dawley (SD) male rats into a normal control group (NC; n = 9) and an IgAN model group (n = 8). Read More

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http://dx.doi.org/10.1016/j.amjms.2019.11.011DOI Listing

Evaluation of the Safety and Efficacy of Avacopan, a C5a Receptor Inhibitor, in Patients With Antineutrophil Cytoplasmic Antibody-Associated Vasculitis Treated Concomitantly With Rituximab or Cyclophosphamide/Azathioprine: Protocol for a Randomized, Double-Blind, Active-Controlled, Phase 3 Trial.

JMIR Res Protoc 2020 Apr 7;9(4):e16664. Epub 2020 Apr 7.

Research and Development, ChemoCentryx, Inc, Mountain View, CA, United States.

Background: Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis is a serious, often life-threatening disease. In new-onset disease or a relapse, the standard treatment is immunosuppressive therapy with glucocorticoids; these therapies are associated with substantial short- and long-term toxicity. Complement component 5a (C5a) binding to C5a receptor (C5aR) may play a central role in the pathogenesis of ANCA-associated vasculitis. Read More

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http://dx.doi.org/10.2196/16664DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7175182PMC

HUANGKUISIWUFANG inhibits pyruvate dehydrogenase to improve glomerular injury in anti-Thy1 nephritis model.

J Ethnopharmacol 2020 May 19;253:112682. Epub 2020 Feb 19.

Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Nanjing University of Chinese Medicine, Nanjing, 210023, China; Jiangsu Key Laboratory for High Technology Research of TCM Formulae, Nanjing University of Chinese Medicine, Nanjing 210023, China. Electronic address:

Ethnopharmacological Relevance: Huangkuisiwufang (HKSWF) is composed of Abelmoschus manihot (L.) Medik., Astragalus mongholicus, Polygonum cuspidatum, Curcuma longa L. Read More

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http://dx.doi.org/10.1016/j.jep.2020.112682DOI Listing

Socioeconomic Position and Incidence of Glomerular Diseases.

Clin J Am Soc Nephrol 2020 Mar 20;15(3):367-374. Epub 2020 Feb 20.

Division of Nephrology and.

Background And Objectives: Social deprivation is a recognized risk factor for undifferentiated CKD; however, its association with glomerular disease is less well understood. We sought to investigate the relationship between socioeconomic position and the population-level incidence of biopsy-proven glomerular diseases.

Design, Setting, Participants, & Measurements: In this retrospective cohort study, a provincial kidney pathology database (2000-2012) was used to capture all incident cases of membranous nephropathy (=392), IgA nephropathy (=818), FSGS (=375), ANCA-related GN (ANCA-GN, =387), and lupus nephritis (=389) in British Columbia, Canada. Read More

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http://dx.doi.org/10.2215/CJN.08060719DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7057310PMC

[Glomerulonephritis, diseases not only important for nephrologists].

Authors:
Rolf A K Stahl

Dtsch Med Wochenschr 2020 Feb 18;145(4):223-231. Epub 2020 Feb 18.

Chronic kidney disease (CKD) is an increasing health problem in all societies. The role of diabetes mellitus and hypertension in CKD is well established in the medical community. This is not necessarily the case for the various forms of glomerulonephitis (GN). Read More

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http://dx.doi.org/10.1055/a-0974-9461DOI Listing
February 2020

Innate Lymphoid Cells in Renal Inflammation.

Front Immunol 2020 29;11:72. Epub 2020 Jan 29.

III Department of Medicine and Hamburg Center for Translational Immunology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Since their identification as a separate family of leukocytes, Innate lymphoid cells (ILCs) have been shown to play crucial roles in immune-mediated diseases and repair mechanisms that restore tissue integrity after injury. ILCs mainly populate non-lymphoid tissues where they form intricate circuits with parenchymal cells to regulate tissue immunity and organ homeostasis. However, the specific phenotype and function of ILC populations that reside in specific anatomical locations, such as the kidney, still remains poorly understood. Read More

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http://dx.doi.org/10.3389/fimmu.2020.00072DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7000421PMC
January 2020