12,453 results match your criteria Glomerulonephritis Chronic


Complete biopsy-proven resolution of deposits in recurrent proliferative glomerulonephritis with monoclonal IgG deposits (PGNMIGD) following rituximab treatment in renal allograft.

BMC Nephrol 2019 Feb 14;20(1):53. Epub 2019 Feb 14.

Department of Pathology, Division of Renal and Transplant Pathology, Ohio State University Wexner Medical Center, M018 Starling-Loving Hall, 320 W 10th Ave, Columbus, OH, 43210, USA.

Background: Proliferative glomerulonephritis with monoclonal IgG deposits (PGNMIGD) is a disease entity classified under the group of "Monoclonal gammopathy-related kidney diseases", and can recur after transplant. Clinical remission of proteinuria in patients with PGNMIGD has been previously shown following anti-B cell and/or anti-plasma cell therapies. Our case is the first to show complete histologic resolution of the glomerular monoclonal IgG kappa deposits in a case of recurrent PGNMIGD in renal allograft after rituximab and steroid treatment. Read More

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https://bmcnephrol.biomedcentral.com/articles/10.1186/s12882
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http://dx.doi.org/10.1186/s12882-019-1239-8DOI Listing
February 2019
1 Read

Comparing outcomes of biopsy-proven anti-neutrophil cytoplasmic autoantibody-associated glomerulonephritis patients treated with cyclophosphamide in the 20th and 21st centuries: a 23-year study.

Clin Kidney J 2019 Feb 11;12(1):42-48. Epub 2018 Sep 11.

Renal Department, Royal Preston Hospital, Preston, UK.

Background: Anti-neutrophil cytoplasmic autoantibody (ANCA)-associated vasculitis (AAV) is a multisystem autoimmune disorder associated with significant morbidity and mortality. Approximately 80-90% of patients have circulating ANCAs. Long-term outcomes appear to be improving. Read More

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http://dx.doi.org/10.1093/ckj/sfy084DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366142PMC
February 2019
1 Read

[Long-term results of chest wall arteriovenous graft for establishing hemodialysis access].

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 2019 Feb;33(2):227-231

Department of Vascular and Endovascular Surgery, Peking University First Hospital, Beijing, 100034, P.R.China.

Objective: To explore the role of chest wall arteriovenous graft (CWAVG) for establishing hemodialysis access in patients with end-stage renal disease.

Methods: A retrospective analysis was made on the clinical data of 12 patients with end-stage renal disease who underwent CWAVG for establishing hemodialysis access between January 2014 and June 2015. There were 3 males and 9 females with an average age of 63. Read More

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http://dx.doi.org/10.7507/1002-1892.201802003DOI Listing
February 2019
1 Read

[Essential mixed cryoglobulinemia type II: case report.]

Rev Fac Cien Med Univ Nac Cordoba 2018 11 13;75(4):292-298. Epub 2018 Nov 13.

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The cryoglobulinemic syndrome is produced by precipitating immunoglobulins at low temperatures. Its production is associated with several causes, such as lymphoproliferative disorders, chronic infections and autoimmune disorders. However, the etiology is unknow. Read More

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http://dx.doi.org/10.31053/1853.0605.v74.n3.17550DOI Listing
November 2018
2 Reads

Relationship of Remodeling of Carotid Arteries and Left Ventricular Geometry in Patients With Chronic Glomerulonephritis.

Kardiologiia 2018 Nov 18;58(4):45-52. Epub 2018 Nov 18.

Кыргызская государственная медицинская академия им. И. К. Ахунбаева; Кыргызско-Российский Славянский университет им. первого Президента России Б. Н. Ельцина.

Purpose: to study clinical-functional features of remodeling of carotid arteries and its relation to restructuring of the left ventricle (LV) in patients with chronic glomerulonephritis at pre-dialysis stage.

Materials And Methods: We examined 269 patients (189 men, 80 women) with chronic glomerulonephritis (CGN) aged 17-71 years, at pre-dialysis stages of the disease. We analyzed biochemical parameters of peripheral blood with the determination of daily proteinuria and glomerular filtration rate (GFR). Read More

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http://dx.doi.org/10.18087/cardio.2018.4.10108DOI Listing
November 2018
1 Read

The role of podocytes dysfunction in chronic glomerulonephritis progression.

Ter Arkh 2018 Jun;90(6):92-97

I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of Russia, Moscow, Russia.

In the review, the mechanisms of podocytes damage underlying the development of proteinuria and progression of glomerulosclerosis in chronic glomerulonephritis are discussed in detail. The results of experimental and clinical studies are presented. Under the different immune and non-immune factors the podocytes form a stereotyped response to damage consisting in the reorganization of the actin cytoskeleton, foot process effacement, the detachment of podocytes from the glomerular basement membrane, and the appearance of specific podocyte proteins and whole cells (podocyturia) in the urine. Read More

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http://ter-arkhiv.ru/en/archive/2018/vol-90-6-2018/14_2730/?
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http://dx.doi.org/10.26442/terarkh201890692-97DOI Listing
June 2018
5 Reads

Relationship between serologic profile (ANCA type) and clinical features of renal involvement in ANCA-associated vasculitides.

Ter Arkh 2018 Jun;90(6):15-21

I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenov University), Moscow, Russia.

Aim: To compare the frequency, clinical features and outcomes of renal involvement in ANCA-associated vasculitides (AAV) in patients with antibodies against proteinase-3 (pr3-ANCA) and myeloperoxidase (MPO-ANCA).

Materials And Methods: In our retrospective study we enrolled 264 patients, 94 males and 170 females, median age 53 [36; 62] years. Among them 157 were pr3-ANCA positive and 107 were MPO-ANCA positive. Read More

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http://dx.doi.org/10.26442/terarkh201890615-21DOI Listing
June 2018
1 Read

Anemia and Iron Deficiency in Children with Chronic Kidney Disease (CKD): Data from the Know-Ped CKD Study.

J Clin Med 2019 Jan 29;8(2). Epub 2019 Jan 29.

Department of Pediatrics, Yonsei University College of Medicine, Yonsei-ro 50, Seodaemun-gu, C.P.O. Box 8044, Seoul 03722, Korea.

Children with chronic kidney disease (CKD) are at high risk of anemia, an important risk factor for cardiovascular disease and poor quality of life. The present study used baseline data from the Korean cohort study for Outcome in patients With Pediatric Chronic Kidney Disease (KNOW-PedCKD). A Total of 437 patients was included in the analyses excluding missing data. Read More

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http://dx.doi.org/10.3390/jcm8020152DOI Listing
January 2019
4 Reads

Development of anti-glomerular basement membrane glomerulonephritis during the course of IgA nephropathy: a case report.

BMC Nephrol 2019 Jan 25;20(1):25. Epub 2019 Jan 25.

Department of Nephrology and Blood Purification, Kidney Disease Center, Tokyo Medical University Hachioji Medical Center, 1163 Tatemachi, Hachioji, Tokyo, 193-0998, Japan.

Background: Anti-glomerular basement membrane (GBM) glomerulonephritis does not usually coexist with another glomerulonephritis such as IgA nephropathy. We present a rare case having a combination of these two diseases, and furthermore, histological evaluation could be performed before and after the development of anti-GBM glomerulonephritis over a period of only10 months.

Case Presentation: A 66-year-old woman was admitted with complaints of microscopic hematuria and mild proteinuria for the past 3 years. Read More

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http://dx.doi.org/10.1186/s12882-019-1207-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347754PMC
January 2019
2 Reads

Bortezomib Maintenance for the Treatment of Monoclonal Gammopathy of Renal Significance.

Mediterr J Hematol Infect Dis 2019 1;11(1):e2019007. Epub 2019 Jan 1.

Tom Baker Cancer Center, Department of Medical Oncology and Hematology, Calgary, AB, Canada.

Monoclonal gammopathy of renal significance (MGRS) defines renal diseases resulting from the nephrotoxic effects of monoclonal proteins secreted from non-malignant clonal B cells or plasma cells, that do not meet criteria for multiple myeloma, Waldenstrom's macroglobulinemia, chronic lymphocytic leukemia, or lymphomas. Renal disease in MGRS can result from monoclonal immunoglobulin deposition to different parts of the kidney and includes a wide spectrum of glomerular, tubulointerstitial and vascular renal diseases. Recognizing MGRS is important because renal outcomes are poor and treatments targeting the underlying clonal disease have been associated with improved renal survival. Read More

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http://dx.doi.org/10.4084/MJHID.2019.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6328037PMC
January 2019
2 Reads

Acute IgA-Dominant Glomerulonephritis Associated with Syphilis Infection in a Pregnant Teenager: A New Disease Association.

J Clin Med 2019 Jan 18;8(1). Epub 2019 Jan 18.

Department of Pathology, National Institute of Cardiology "Ignacio Chávez", Mexico City 14000, Mexico.

Chronic kidney disease (CKD) is increasingly recognized as a risk factor in pregnancy; the differential diagnosis between CKD and preeclampsia (PE) may be of pivotal importance for pregnancy management and for early treatment of CKD. Acknowledging this connection may be useful also in a wider context, such as in the case reported in this paper, which for the first time describes an association between syphilis infection and IgA-dominant glomerulonephritis. A 16-year-old woman, referred to a general hospital due to a seizure, was found to be unknowingly pregnant. Read More

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http://www.mdpi.com/2077-0383/8/1/114
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http://dx.doi.org/10.3390/jcm8010114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6352144PMC
January 2019
7 Reads

CKD.QLD: PROFILE OF PATIENTS WITH CHRONIC KIDNEY DISEASE (CKD) FROM REGIONAL QUEENSLAND, AUSTRALIA: A REGISTRY REPORT.

Nephrology (Carlton) 2019 Jan 20. Epub 2019 Jan 20.

NHMRC CKD.CRE and CKD.QLD, University of Queensland, Brisbane, Queensland, Australia.

Background: Chronic Kidney Disease, Queensland (CKD.QLD) is a multidisciplinary, collaborative research platform for CKD in Queensland. All public renal services contribute towards the CKD Registry, including Toowoomba Hospital which is a referral hospital for Darling Downs Health (DDH) serving largely regional population in Queensland. Read More

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http://dx.doi.org/10.1111/nep.13567DOI Listing
January 2019
2 Reads

TRPC6 inactivation does not affect loss of renal function in nephrotoxic serum glomerulonephritis in rats, but reduces severity of glomerular lesions.

Biochem Biophys Rep 2019 Mar 8;17:139-150. Epub 2019 Jan 8.

Department of Biology and Biochemistry, University of Houston, Houston, TX, USA.

Canonical transient receptor potential-6 (TRPC6) channels have been implicated in a variety of chronic kidney diseases including familial and acquired forms of focal and segmental glomerulosclerosis (FSGS) and renal fibrosis following ureteral obstruction. Here we have examined the role of TRPC6 in progression of inflammation and fibrosis in the nephrotoxic serum (NTS) model of crescentic glomerulonephritis. This was assessed in rats with non-functional TRPC6 channels due to genomic disruption of an essential domain in TRPC6 channels ( rats) and wild-type littermates ( rats). Read More

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http://dx.doi.org/10.1016/j.bbrep.2018.12.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6325086PMC
March 2019
1 Read

Dabigatran causing severe acute kidney injury in a patient with liver cirrhosis.

CEN Case Rep 2019 Jan 18. Epub 2019 Jan 18.

Renal Unit, Department of Medicine, Queen Elizabeth Hospital, 30 Gascoigne Road, Kowloon, Hong Kong, SAR, China.

Anticoagulant-related nephropathy (ARN), a significant but frequently undiagnosed problem in patients receiving anticoagulation, is found to be associated with increased renal morbidity and all-cause mortality. While ARN is mainly associated with warfarin use, recent case reports suggest that it may also occur in patients taking direct oral anticoagulants (DOAC). We report a patient who had a history of alcoholic liver cirrhosis and paroxysmal atrial fibrillation, and received dabigatran 110 mg twice daily for 1 year. Read More

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http://dx.doi.org/10.1007/s13730-019-00378-4DOI Listing
January 2019
2 Reads

Whole-Exome Sequencing Enables a Precision Medicine Approach for Kidney Transplant Recipients.

J Am Soc Nephrol 2019 Feb 17;30(2):201-215. Epub 2019 Jan 17.

Division of Nephrology,

Background: Whole-exome sequencing (WES) finds a CKD-related mutation in approximately 20% of patients presenting with CKD before 25 years of age. Although provision of a molecular diagnosis could have important implications for clinical management, evidence is lacking on the diagnostic yield and clinical utility of WES for pediatric renal transplant recipients.

Methods: To determine the diagnostic yield of WES in pediatric kidney transplant recipients, we recruited 104 patients who had received a transplant at Boston Children's Hospital from 2007 through 2017, performed WES, and analyzed results for likely deleterious variants in approximately 400 genes known to cause CKD. Read More

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http://dx.doi.org/10.1681/ASN.2018060575DOI Listing
February 2019
5 Reads

Glomerular membrane attack complex is not a reliable marker of ongoing C5 activation in lupus nephritis.

Kidney Int 2019 Jan 8. Epub 2019 Jan 8.

Centre for Inflammatory Disease, Imperial College London, London, UK.

Complement plays an important role in the pathogenesis of lupus nephritis (LN). With the emergence of therapeutic complement inhibition, there is a need to identify patients in whom complement-driven inflammation is a major cause of kidney injury in LN. Clinical and histopathological data were obtained retrospectively from 57 biopsies with class III, IV, and V LN. Read More

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http://dx.doi.org/10.1016/j.kint.2018.09.027DOI Listing
January 2019
1 Read

Therapy Side Effects in Systemic Lupus Erythematosus.

Curr Health Sci J 2018 Jul-Sep;44(3):316-321. Epub 2018 Jul 15.

Department of Pharmacology, University of Medicine and Pharmacy of Craiova, Romania.

Glucosteroids (GS) are widely used drugs for various inflammatory pathologies (Nephrotic syndrome, Proliferative glomerulonephritis, Extramembrane glomerulonephritis, Nephropathy of the Nodous Poliarterita (PAN), Nephropathy from purple Henoch-Schonlein, lupus nephropathy (LN), Acute adrenal insufficiency Waterhouse-Friederichsen, Chronic adrenal insufficiency Addison, Systemic Lupus Erythematosus (SLE), Polymyositis and dermatomyositis, Chronic granulomatosis, Crohn's disease, Hemorrhagic rectocolitis, Hemolytic anemias, Acute leukemias and chronic lymphocytic leukemia, Hodgkin's lymphoma). Although they are prescribed for their anti-inflammatory and immunosuppressive properties, they also have many side effects, hyperglycemia being one of the most common and representative, which is why these drugs need careful monitoring when administered over the long term. This paper presents the case of a 39 year old patient diagnosed with systemic lupus erythematosus (SLE) with class IV lupus nephropathy (LN) who developed numerous complications due to the pathogenic side effects: diabetes, amenorrhea, recurrent infections, and depression. Read More

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http://dx.doi.org/10.12865/CHSJ.44.03.18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311221PMC
July 2018
6 Reads

Integration of Genetic Testing and Pathology for the Diagnosis of Adults with FSGS.

Clin J Am Soc Nephrol 2019 Jan 15. Epub 2019 Jan 15.

Division of Nephrology and

Background And Objectives: FSGS and nephrotic syndrome studies have shown that single gene causes are more likely to be found in pediatric cases than adults. Consequently, many studies have examined limited gene panels in largely pediatric cohorts.

Design, Setting, Participants, & Measurements: Whole-exome sequencing was performed in adults with FSGS diagnosed between 1976 and 2017 in the Toronto GN Registry. Read More

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http://cjasn.asnjournals.org/lookup/doi/10.2215/CJN.08750718
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http://dx.doi.org/10.2215/CJN.08750718DOI Listing
January 2019
11 Reads

Proteinuria Reduction as a Surrogate End Point in Trials of IgA Nephropathy.

Clin J Am Soc Nephrol 2019 Jan 11. Epub 2019 Jan 11.

Division of Renal Diseases and Hypertension, University of Minnesota, Minneapolis, Minnesota

IgA nephropathy (IgAN) is an important cause of ESKD for which there are no approved therapies. A challenge for evaluating treatments for IgAN is the usual long time course for progression to ESKD. The aim of this Kidney Health Initiative project was to identify surrogate end points that could serve as reliable predictors of a treatment's effect on long-term kidney outcomes in IgAN and be used as a basis for approval. Read More

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http://cjasn.asnjournals.org/lookup/doi/10.2215/CJN.08600718
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http://dx.doi.org/10.2215/CJN.08600718DOI Listing
January 2019
5 Reads

Dietary Chrysin Suppresses Formation of Actin Cytoskeleton and Focal Adhesion in AGE-Exposed Mesangial Cells and Diabetic Kidney: Role of Autophagy.

Nutrients 2019 Jan 9;11(1). Epub 2019 Jan 9.

Department of Food and Nutrition, Hallym University, Chuncheon, Kangwon-do 24252, Korea.

Advanced glycation end products (AGE) play a causative role in the development of aberrant phenotypes of intraglomerular mesangial cells, contributing to acute/chronic glomerulonephritis. The aim of this study was to explore mechanistic effects of the flavonoid chrysin present in bee propolis and herbs on actin dynamics, focal adhesion, and the migration of AGE-exposed mesangial cells. The in vitro study cultured human mesangial cells exposed to 33 mM glucose and 100 μg/mL AGE-bovine serum albumin (AGE-BSA) for up to 5 days in the absence and presence of 1⁻20 μM chrysin. Read More

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http://www.mdpi.com/2072-6643/11/1/127
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http://dx.doi.org/10.3390/nu11010127DOI Listing
January 2019
5 Reads

Successful entecavir plus prednisolone treatment for hepatitis B virus-associated membranoproliferative glomerulonephritis: A case report.

Medicine (Baltimore) 2019 Jan;98(2):e14014

Department of Medicine Kidney Center.

Rationale: Adult-onset hepatitis B virus-associated membranoproliferative glomerulonephritis (HBV-MPGN) is generally refractory, and an effective treatment for this condition has not been established. The indications for steroids in HBV-MPGN are an important clinical concern.

Patient Concerns: A 28-year-old woman with a chronic hepatitis B virus infection developed nephrotic syndrome in her second month of pregnancy, with urinary protein levels of 3 to 10 g/d that continued into her postpartum period. Read More

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http://dx.doi.org/10.1097/MD.0000000000014014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6336600PMC
January 2019
1 Read

Anticoagulant Related Nephropathy Induced by Dabigatran.

Case Rep Nephrol 2018 9;2018:7381505. Epub 2018 Dec 9.

Department of Medicine, University of Calgary, Canada.

We describe a case of biopsy-proven dabigatran related nephropathy in a patient without underlying IgA nephropathy. To date, dabigatran related nephropathy was only reported in patients with concurrent or undiagnosed IgA nephropathy, suggesting that it may predispose patients to dabigatran associated injury. The patient is an 81-year-old woman with multiple medical comorbidities, including nonvalvular atrial fibrillation, who was anticoagulated with dabigatran. Read More

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http://dx.doi.org/10.1155/2018/7381505DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304482PMC
December 2018
4 Reads

Protective Effects of Epigallocatechin-3-Gallate from Green Tea in Various Kidney Diseases.

Adv Nutr 2019 Jan;10(1):112-121

Medical Proteomics Unit, Office for Research and Development, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.

Kidney diseases are common health problems worldwide. Various etiologies (e.g. Read More

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https://academic.oup.com/advances/advance-article/doi/10.109
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http://dx.doi.org/10.1093/advances/nmy077DOI Listing
January 2019
16 Reads

A case report of ocular tuberculosis in a patient with membranous nephropathy.

Medicine (Baltimore) 2019 Jan;98(1):e13892

Department of Chronic Communicable Disease, Nanjing Municipal Center for Disease Control and Prevention, Nanjing, China.

Rationale: Membranous nephropathy (MN), a chronic kidney disease (CKD), due to hypoproteinemia, malnutrition, anemia, long-term intake of immunosuppressive agents, changes in cellular immune state, and decrease in antimicrobial peptides, is a high risk for Mycobacterium tuberculosis (MTB) infection, which can cause tuberculosis (TB). TB manifests by various clinical symptoms. Ocular symptoms is a rare presentation of TB. Read More

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http://dx.doi.org/10.1097/MD.0000000000013892DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6344117PMC
January 2019
5 Reads

[The 467th case: proteinuria, periungual fibromas, and facial steatadenomas].

Zhonghua Nei Ke Za Zhi 2019 Jan;58(1):74-77

Department of Nephrology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Science, Beijing 100730, China.

A 22-year-old manpresented as a refractory nephrotic syndrome with edema and proteinuria for more than one year. Physical examination revealed facial steatadenomas and periungual fibromas. Images were characterized by hamartomatous lesions in multiple organs, including the central nervous system, heart, lungs, liver, and kidneys. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0578-1426.2019.01.014DOI Listing
January 2019
1 Read

Hepatitis C virus antibodies in outpatients with chronic kidney disease.

Clin Exp Hepatol 2018 Dec 3;4(4):267-270. Epub 2018 Dec 3.

Department Internal Medicine II of Slovak Medical University, F.D. Roosevelt University Hospital, Banská Bystrica, Slovak Republic.

Aim Of The Study: To determine the seroprevalence of hepatitis C virus (HCV) in outpatients with chronic kidney disease (CKD) attending a nephrology clinic.

Material And Methods: Prospective observational study on consecutive outpatients attending a nephrology clinic. Inclusion criteria were age > 18 years, CKD, informed consent. Read More

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http://dx.doi.org/10.5114/ceh.2018.80129DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311740PMC
December 2018
1 Read

C-C chemokine receptor type 2 mediates glomerular injury and interstitial fibrosis in focal segmental glomerulosclerosis.

Nephrol Dial Transplant 2018 Dec 28. Epub 2018 Dec 28.

Nephrologisches Zentrum, Medizinische Klinik und Poliklinik IV, Klinikum der Universität München, Ludwig-Maximilians-Universität München, Munich, Germany.

Background: Glomerulosclerosis and tubulointerstitial fibrosis are hallmarks of chronic kidney injury leading to end-stage renal disease. Inflammatory mechanisms contribute to glomerular and interstitial scarring, including chemokine-mediated recruitment of leucocytes. In particular, accumulation of C-C chemokine receptor type 2 (CCR2)-expressing macrophages promotes renal injury and fibrotic remodelling in diseases like glomerulonephritis and diabetic nephropathy. Read More

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http://dx.doi.org/10.1093/ndt/gfy380DOI Listing
December 2018
1 Read

C3 Glomerulonephritis With Multiple Mutations in Complement Factor H.

Iran J Kidney Dis 2018 Nov;12(6):376-381

Chronic Kidney Disease Research Center, Department of Nephrology, Labbafinejad Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Complement C3 glomerulopathy refers to a disease process in which abnormal control of complement activation or degradation results in predominant C3 fragment deposition within the glomerulus and causes glomerular damage. Abnormal control of the complement alternative pathway is a well-established risk factor for the occurrence of C3 glomerulonephritis. It is the first reported case in Iran with multiple mutations in complement factor H, with one of these mutations we have expected in hemolytic uremic syndrome rather than C3 glomerulopathy Genetic analysis showed that the molecular abnormalities of factor H led to complement factor H malfunction that were polymorphous and not restricted to the C-terminal domains of the protein. Read More

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November 2018
1 Read
0.979 Impact Factor

Clinicopathological profile of pediatric renal biopsies at a tertiary care hospital, Pakistan.

Saudi J Kidney Dis Transpl 2018 Nov-Dec;29(6):1403-1409

The Kidney Center, Karachi, Pakistan.

Renal biopsy is an important tool for the diagnosis of acute and chronic glomerular diseases in children. We aimed to analyze the spectrum of clinical indications and histopathological patterns (HPP) in children who underwent renal biopsy (RB). This is a retrospective review of case records of 108 renal biopsies carried out from January 2010 to December 2015 at the Pediatric Nephrology Department, National Institute of Child Health Karachi, Pakistan. Read More

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http://www.sjkdt.org/text.asp?2018/29/6/1403/248290
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http://dx.doi.org/10.4103/1319-2442.248290DOI Listing
December 2018
13 Reads

An Investigation of the Prescription Patterns of Chinese Herbal Products for Chronic Glomerulonephritis Patients: A Hospital-Based Cross-Sectional Study.

Evid Based Complement Alternat Med 2018 15;2018:5080764. Epub 2018 Nov 15.

Division of Chinese Internal Medicine, Center for Traditional Chinese Medicine, Chang Gung Memorial Hospital, Taoyuan, Taiwan.

Chronic kidney disease (CKD) has a high incidence and prevalence worldwide, and chronic glomerulonephritis (CGN) is one of the main causes of CKD. Therefore, it is important to diagnose and treat CGN early. The purpose of this study is to analyze the prescription patterns and frequencies of Chinese herbal products (CHPs) for CGN by using a hospital-based database from the Chang Gung Memorial Hospital (CGMH), a large, tertiary hospital system in Taiwan, and to evaluate the safety and possible efficacy of CHPs by blood test. Read More

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http://dx.doi.org/10.1155/2018/5080764DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276402PMC
November 2018
2 Reads

Being Overweight Is Related to Faster Decline in Annual Glomerular Filtration Rate in Kidney Transplant.

Transplant Proc 2018 Dec 18;50(10):3392-3396. Epub 2018 Apr 18.

Centro de Nefrología, Hospital de Clínicas, Facultad de Medicina, UdeLaR, Montevideo, Uruguay.

Few studies have examined the relationship between non-immunological factors and glomerular filtration rate (GFR) decline in kidney transplant. Correcting these factors in native kidneys slows the progression of chronic kidney disease. The aim of this study was to analyze the association between the control of non-immunological factors and the annual decline of GFR. Read More

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http://dx.doi.org/10.1016/j.transproceed.2018.04.040DOI Listing
December 2018
2 Reads

Kartagener syndrome complicated by immunoglobulin A nephropathy.

Int Med Case Rep J 2018 10;11:359-362. Epub 2018 Dec 10.

Division of Nephrology, Department of Internal Medicine, Jichi Medical University, Tochigi, Japan,

We herein report the case of a 36-year-old woman with Kartagener syndrome (KS), which is an autosomal recessive disorder defined by a triad of bronchiectasis, sinusitis, and situs inversus, with complications of asymptomatic microhematuria and proteinuria. She was finally diagnosed with biopsy-proven immunoglobulin (Ig) A nephropathy. KS constitutes a subgroup of primary ciliary dyskinesia (PCD) characterized by structural and/or functional ciliary abnormalities resulting in sinopulmonary involvement with varying severity. Read More

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http://dx.doi.org/10.2147/IMCRJ.S185887DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6292226PMC
December 2018
1 Read

MIF in kidney diseases : A story of Dr. Jekyll and Mr. Hyde.

Authors:
P Boor

Pathologe 2018 Dec 19. Epub 2018 Dec 19.

Institute of Pathology, University Clinic, RWTH University of Aachen, Pauwelsstr. 30, 52074, Aachen, Germany.

Background: Macrophage migration-inhibitory factor (MIF) is a cytokine best known for its proinflammatory and disease-aggravating role in a number of conditions, including atherosclerosis, autoimmune diseases, sepsis, and glomerulonephritides.

Objectives: In our studies we aimed to define the role of MIF on local renal resident cells, in particular the renal epithelium.

Results: We have shown that MIF exerts local effects on glomerular cells, in particular the parietal epithelial cells and mesangial cells, promoting their pathological proliferation and aggravating disease course of a murine model of immune-mediated glomerulonephritis. Read More

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http://link.springer.com/10.1007/s00292-018-0548-1
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http://dx.doi.org/10.1007/s00292-018-0548-1DOI Listing
December 2018
12 Reads

Infection-Induced Kidney Diseases.

Front Med (Lausanne) 2018 28;5:327. Epub 2018 Nov 28.

Department of Nephrology and Renal Transplantation, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India.

Infection induced kidney diseases are of concern for clinicians because timely detection and treatment of infections may cure or limit the extent of injury inflicted by microorganisms causing the infections. Infections can cause kidney injury by either direct invasion, or indirectly by immune mediated mechanisms, which manifest as post-infectious glomerulonephritis, or infection-related glomerulonephritis. Clinical manifestations may be acute or chronic depending on the microorganisms, endemic/epidemic nature and source of infection. Read More

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http://dx.doi.org/10.3389/fmed.2018.00327DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6282040PMC
November 2018
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Surgical outcomes of acute type A aortic dissection in dialysis patients.

Gen Thorac Cardiovasc Surg 2018 Dec 14. Epub 2018 Dec 14.

Department of Cardiovascular Surgery, Saitama Medical Center, Jichi Medical University, 1-847 Amanumacho, Omiya-ku, Saitama, 330-8503, Japan.

Background: Acute type A aortic dissection (ATAAD) is relatively uncommon in dialysis patients, and characteristics and repair outcomes are not fully understood.

Patients And Methods: Patients with ATAAD (n = 960) were divided into a dialysis group (n = 19) and non-dialysis group (n = 941), depending on whether they required dialysis for preoperative end-stage renal disease (ESRD). Hospital charts and imaging data were reviewed, and characteristics and outcomes were compared between the groups. Read More

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http://dx.doi.org/10.1007/s11748-018-1051-6DOI Listing
December 2018
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Bevacizumab-associated glomerular microangiopathy.

Mod Pathol 2018 Dec 14. Epub 2018 Dec 14.

Institute of Pathology and Nephropathology Section, University Hospital Hamburg Eppendorf, Hamburg, Germany.

Bevacizumab is a humanized monoclonal IgG1 antibody, which neutralizes vascular endothelial growth factor and is used for treating multiple cancer types. As a known and frequent adverse event, this therapy can lead to renal damage including proteinuria and nephrotic syndrome. In a retrospective approach, we analyzed 17 renal biopsies from patients receiving bevacizumab treatment. Read More

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http://dx.doi.org/10.1038/s41379-018-0186-4DOI Listing
December 2018
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Emerging immunotherapies for autoimmune kidney disease.

Hum Vaccin Immunother 2018 Dec 14. Epub 2018 Dec 14.

a Department of Medicine , Duke University Medical Center , Durham , NC , USA.

Autoimmunity is a leading cause of chronic kidney disease and loss of native and transplanted kidneys. Conventional immunosuppressive therapies can be effective but are non-specific, noncurative, and risk serious side effects such as life-threatening infection and cancer. Novel therapies and targeted interventions are urgently needed. Read More

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https://www.tandfonline.com/doi/full/10.1080/21645515.2018.1
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http://dx.doi.org/10.1080/21645515.2018.1555569DOI Listing
December 2018
8 Reads

Pulsed dye laser repurposed: Treatment of refractory molluscum contagiosum in renal transplant patient.

Transpl Infect Dis 2018 Dec 12:e13036. Epub 2018 Dec 12.

Department of Dermatology, College of Medicine, The University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma.

We present a case of a 15-year-old girl with an allogenic renal transplant secondary to chronic glomerulonephritis of unknown etiology who presented with treatment refractory molluscum contagiosum of the lower extremities and perineum. Treatment of mollusca with pulsed dye laser resulted in a clinically significant and sustained response. To our knowledge, this is the first report of a successful treatment of molluscum contagiosum with pulsed dye laser in the setting of a renal transplant. Read More

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http://dx.doi.org/10.1111/tid.13036DOI Listing
December 2018
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Inflammatory demyelinating neuropathies with focal segmental glomerulosclerosis: Two case reports.

Medicine (Baltimore) 2018 Dec;97(49):e13304

Department of Nephrology, Huashan Hospital, Fudan University, Shanghai, China.

Rationale: Inflammatory demyelinating neuropathies such as Guillain-Barré syndrome (GBS), chronic inflammatory demyelinating polyneuropathy (CIDP), and focal segmental glomerulosclerosis (FSGS) are autoimmune disorders that may have a common pathogenesis. Here, we describe 2 unique cases of FSGS, 1 with GBS and the other with CIPD. We believe that reviewing these multisystemic diseases will help in better understanding of FSGS pathogenesis. Read More

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http://dx.doi.org/10.1097/MD.0000000000013304DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6310532PMC
December 2018
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MEditerranean FeVer ( MEFV ) gene mutations in glomerulonephritides: a clinicopathological study

Turk J Med Sci 2018 Dec 12;48(6):1182-1191. Epub 2018 Dec 12.

Department of Nephrology, Faculty of Medicine, Ankara University, Ankara, Turkey

Background/aim: The aim of this study is to determine the ME diterranean F e V er ( MEFV ) gene mutation carrier rate in patients with glomerulonephritis and to investigate the association between disease features and MEFV variants.

Materials And Methods: Medical records regarding clinical, laboratory, histopathological, and prognostic features of 200 adult patients with biopsy-proven glomerulonephritis were evaluated retrospectively. Exons 2 and 10 of the MEFV gene of each patient were sequenced by next-generation sequencing. Read More

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http://dx.doi.org/10.3906/sag-1805-274DOI Listing
December 2018

Inflammasomes in the Kidney.

Exp Suppl 2018 ;108:177-210

Centre for Inflammatory Diseases, Monash University Department of Medicine, Monash Medical Centre, Clayton, VIC, Australia.

Inflammasomes influence a diverse range of kidney disease, including acute and chronic kidney diseases, and those mediated by innate and adaptive immunity. Both IL-18 and in particular IL-1β are validated therapeutic targets in several kidney diseases. In addition to leukocyte-derived inflammasomes, renal tissue cells express functional inflammasome components. Read More

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http://dx.doi.org/10.1007/978-3-319-89390-7_8DOI Listing
January 2018
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Potential Blood Pressure Goals in IgA Nephropathy: Prevalence, Awareness, and Treatment Rates in Chronic Kidney Disease Among Patients with Hypertension in China (PATRIOTIC) Study.

Kidney Blood Press Res 2018 30;43(6):1786-1795. Epub 2018 Nov 30.

Background/aims: IgA nephropathy is the most prevalent form of primary glomerulonephritis worldwide. Among patients with kidney disease, hypertension is one of the most important risk factors of disease progression. Considering the limited evidence regarding the appropriate blood pressure (BP) goal for patients with IgA nephropathy, our aim was to critically appraise the potential BP goal in IgA nephropathy. Read More

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http://dx.doi.org/10.1159/000495636DOI Listing
November 2018
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1.820 Impact Factor

Membranous glomerulonephritis - a common, unspecific pattern of glomerular injury.

Pol J Pathol 2018 ;69(3):209-218

Membranous nephropathy (MN) is a chronic form of glomerulonephritis, associated with the presence of immune complexes beneath the podocytes on the subepithelial region of glomerular capillaries. MN is not a disease entity but one of relatively common patterns of glomerular injury that may be a manifestation of primary renal autoimmunological reaction or may evolve as a phenomenon secondary to wide spectrum of systemic processes. Read More

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http://dx.doi.org/10.5114/pjp.2018.79540DOI Listing
January 2018
3 Reads

The association of hepatitis C infection with the onset of CKD and progression into ESRD.

Semin Dial 2018 Nov 29. Epub 2018 Nov 29.

Division of Nephrology, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts.

Hepatitis C virus (HCV) infection is not only an important cause of chronic liver disease, but extrahepatic manifestations are common and include chronic kidney disease (CKD). HCV is classically associated with cryoglobulinemic glomerulonephritis in the context of mixed cryoglobulinemia syndrome, but other glomerular diseases also occur and may be significantly under-recognized. HCV may cause glomerular disease by immune complex deposition; however, other potential mechanisms by which HCV promotes CKD include a direct cytopathic effect of the virus on renal tissue, and by its association with accelerated atherosclerosis, insulin resistance, and chronic inflammation. Read More

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http://doi.wiley.com/10.1111/sdi.12759
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http://dx.doi.org/10.1111/sdi.12759DOI Listing
November 2018
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Sex-specific analysis of haemodialysis prevalence, practices and mortality over time: the Austrian Dialysis Registry from 1965 to 2014.

Nephrol Dial Transplant 2018 Nov 21. Epub 2018 Nov 21.

Clinical Division of Nephrology and Dialysis, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria.

Background: Despite a higher prevalence of chronic kidney disease among women, more men than women start renal replacement therapy (RRT). We hypothesized that gender differences in health care access exist and therefore aimed at determining whether characteristics and outcomes of haemodialysis patients over time differ by sex.

Methods: We studied all 28 323 adults who began haemodialysis during 1965-2014 in the Austrian Dialysis Registry, analysing trends in patient characteristics by sex and decade with mortality (via Cox regression), which was compared with the mortality of the Austrian general population. Read More

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https://academic.oup.com/ndt/advance-article/doi/10.1093/ndt
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http://dx.doi.org/10.1093/ndt/gfy322DOI Listing
November 2018
9 Reads

Efficacy of Chinese herb Cistanche Yishen granules in treatment of tinnitus for patients with chronic nephritis.

J Cell Biochem 2018 Nov 26. Epub 2018 Nov 26.

Department of Nephrology, Jiangsu Province Hospital of TCM, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China.

Objective: This study aimed to investigate the efficacy of Chinese herb Cistanche Yishen granules (CYG) in the treatment of tinnitus for patients with chronic nephritis.

Methods: A total of 89 adult patients were diagnosed with chronic glomerulonephritis from January 2016 to December 2017. All the patients were randomly divided into two groups, such as the control group and the CYG group. Read More

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http://dx.doi.org/10.1002/jcb.27833DOI Listing
November 2018
1 Read
3.263 Impact Factor

Early growth response protein 1 upregulates long noncoding RNA Arid2-IR to promote extracellular matrix production in diabetic kidney disease.

Am J Physiol Cell Physiol 2018 Nov 21. Epub 2018 Nov 21.

Department of Endocrinology & Metabolism, Nanfang Hospital, Southern Medical University, China.

Diabetic kidney disease (DKD) has surpassed chronic glomerulonephritis as the leading cause of end-stage renal disease (ESRD). Previously, we showed that early growth response protein 1 (Egr1) plays a key role in DKD by enhancing mesangial cell proliferation and extracellular matrix (ECM) production. The long noncoding RNA Arid2-IR has been identified as a Smad3-associated lncRNA in unilateral ureteral obstructive (UUO) kidney disease. Read More

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http://dx.doi.org/10.1152/ajpcell.00167.2018DOI Listing
November 2018
8 Reads
3.780 Impact Factor

Expression of DENDRIN in several glomerular diseases and correlation to pathological parameters and renal failure - preliminary study.

Diagn Pathol 2018 Nov 20;13(1):90. Epub 2018 Nov 20.

Department of Pathology, Forensic medicine and Cytology, University Hospital Centre Split, Split, Croatia.

Background: In glomerular injury dendrin translocates from the slit diaphragm to the podocyte nucleus, inducing apoptosis. We analyzed dendrin expression in IgA glomerulonephritis and Henoch Schönlein purpura (IgAN/HSP) versus in podocytopathies minimal change disease (MCD) and focal segmental glomerulosclerosis (FSGS), and compared it to pathohistological findings and renal function at the time of biopsy and the last follow-up.

Methods: Twenty males and 13 females with median of age 35 years (min-max: 3-76) who underwent percutaneous renal biopsy and had diagnosis of glomerular disease (GD) were included in this retrospective study. Read More

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http://dx.doi.org/10.1186/s13000-018-0767-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6247684PMC
November 2018
40 Reads

LncRNAs expression in adriamycin-induced rats reveals the potential role of LncRNAs contributing to chronic glomerulonephritis pathogenesis.

Gene 2019 Mar 17;687:90-98. Epub 2018 Nov 17.

Department of Pharmacy, The first Affiliated Hospital of Anhui University of Chinese Medicine, 117 Meishan Road, Hefei, China.

Background: Chronic glomerulonephritis (CGN) is the most common form of primary glomerular disease with unclear molecular mechanisms. Currently, limited study on long non-coding RNAs (lncRNAs) in CGN is available. Our study aimed to identify potential lncRNAs and genes in the normal and adriamycin-induced CGN rats, which to explore the potential molecular mechanisms of CGN pathogenesis. Read More

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http://dx.doi.org/10.1016/j.gene.2018.11.050DOI Listing
March 2019
7 Reads

Update on Lupus Nephritis for GPs.

Authors:
M McClure R Jones

Lupus 2018 10;27(1_suppl):11-14

Vasculitis and Lupus Clinic, Addenbrooke's Hospital, Cambridge.

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http://dx.doi.org/10.1177/0961203318801687DOI Listing
October 2018
1 Read