14,041 results match your criteria Glomerulonephritis Chronic


Clinical and pathological characteristics of patients with acute kidney injury in Japan in whom kidney biopsy was performed: a cross-sectional analysis of the Japan Renal Biopsy Registry (J‑RBR).

Clin Exp Nephrol 2022 May 20. Epub 2022 May 20.

Department of Pathology, Keio University School of Medicine, Tokyo, Japan.

Introduction: Acute kidney injury (AKI) is a worldwide concern and it leads to a poor prognosis or end-stage kidney disease. The purpose of this study was to clarify the characteristics of patients with AKI in whom kidney biopsy was performed using data of the Japan Renal Biopsy Registry (J-RBR).

Methods: We screened 38,351 cases that were registered in the J-RBR from 2007 to 2018. Read More

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Bartter-like syndrome induced by tacrolimus in a renal transplanted boy: A Case Report.

Curr Drug Saf 2022 May 18. Epub 2022 May 18.

Interdisciplinary Laboratory of Medical Investigation, Faculty of Medicine, Federal University of Minas Gerais (UFMG), Belo Horizonte, MG, Brazil.

Introduction/background: Losing-salt tubulopathies, such as Bartter syndrome, are rare and usually inherited due to mutations of tubular reabsorption channels of the nephrons. Despite its scarcity, some cases of acquired losing-salt tubulopathies have been described. In this case report, we discuss the main aspects of Bartter syndrome and present a rare pediatric case of probable tacrolimus-induced Bartter-like syndrome in a renal transplanted boy. Read More

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Cryoglobulinemia and double-filtration plasmapheresis: personal experience and literature review.

Ther Apher Dial 2022 May 18. Epub 2022 May 18.

Nephrology, hemodialysis, apheresis and kidney transplantation department, Grenoble University Hospital, Grenoble, France.

Background: Cryoglobulinemia is defined as the presence of an abnormal immunoglobulin that may be responsible for vasculitis of small-caliber vessels. Apheresis can be used in order to temporarily eliminate circulating cryoglobulins. The aim of this study was to assess the effectiveness of apheresis (double-filtration plasmapheresis-DFPP-) in symptomatic and/or severe cryoglobulinemias. Read More

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[IgA vasculitis - similarities and differences to IgA nephropathy].

Ther Umsch 2022 Jun;79(5):260-268

Klinik Rheumatologie & Schmerzmedizin, Bethesda Spital Basel.

IgA vasculitis - similarities and differences to IgA nephropathy IgA vasculitis (IgAV), formerly called Henoch-Schönlein Purpura (HSP) is an immune complex-mediated vasculitis of small vessels typically affecting the skin, gastrointestinal tract, and the kidneys. Based on distinct histopathological and pathophysiological commonalities of IgAV and IgA nephropathy (IgAN) they are viewed as part of a spectrum of IgA-mediated inflammatory syndromes. While the disease course in children is most often benign, IgAV has a high risk of renal and gastrointestinal complications when first appearing in adulthood. Read More

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Effect of Cyclophosphamide and Glucocorticoid Therapy in IgA Nephropathy: A Single-Center Retrospective Analysis.

Kidney360 2022 Mar 19;3(3):506-515. Epub 2022 Jan 19.

Department of Medicine IV, University Freiburg, Medical Center, Freiburg, Germany.

Background: IgA nephropathy (IgAN) is the most common primary glomerulonephritis in adults, which causes ESKD in ≤45% of patients in the long term. The optimal therapeutic approach remains undetermined. In this study, we report the results of a single-center retrospective analysis of patients with IgAN. Read More

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Kidney Disease in Ankylosing Spondylitis: a case series and review of the literature.

J Bras Nefrol 2022 May 13. Epub 2022 May 13.

Centro Hospitalar de Lisboa Central, Hospital Curry Cabral, Departamento de Nefrologia, Lisboa, Portugal.

Background: Kidney disease is a rare manifestation of ankylosing spondylitis (AS) and its pathological alterations remain poorly described. The aim of this study was to investigate the clinical presentation and pathological alterations on kidney biopsy of AS patients and review and discuss the current literature on the issue.

Methods: We retrospectively studied the clinical presentation and kidney pathological alterations of 15 Caucasian AS patients submitted to kidney biopsy between October 1985 and March 2021. Read More

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Septicaemic Listeriosis in a White-Faced Saki (Pithecia pithecia).

J Comp Pathol 2022 Jun 11;194:7-13. Epub 2022 Apr 11.

Phoenix Zoo, Phoenix, Arizona, USA.

A 27-year-old female white-faced saki (Pithecia pithecia) died following an onset of vomiting and ptyalism. Necropsy revealed lesions of suppurative ventriculitis, choroid plexitis, periventricular encephalitis and meningitis with intralesional gram-positive coccobacilli and paired rods. The saki also had suppurative to mononuclear hepatitis, mild intestinal crypt necrosis, proliferative glomerulonephritis, aortic arteriosclerosis, pulmonary interstitial fibrosis, chronic mild epicarditis, ovarian medullary arteriopathy and a focal superficial cerebral fibrotic nodule with surrounding chronic mixed cell inflammation. Read More

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A Rare Case of Nephrotic-Range Proteinuria in Antineutrophil Cytoplasmic Antibodies (ANCA)-Associated Vasculitis.

Cureus 2022 May 10;14(5):e24889. Epub 2022 May 10.

Internal Medicine, BronxCare Health System, New York City, USA.

Granulomatosis with polyangiitis (GPA), or Wegener's granulomatosis as it was formerly referred to, is an antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). GPA is characterized as a necrotizing vasculitis with few or no immune deposits termed pauci-immune deposits, predominantly affecting small and medium arterial vessels, involving the upper and lower respiratory tract as well as glomeruli. Renal manifestations are of critical importance because of the progression that may ensue following onset. Read More

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Long Non-Coding NONRATG001910.2 Promotes the Proliferation of Rat Mesangial Cell Line HBZY-1 Through the miR-339-3p/CTNNB1 Axis.

Front Genet 2022 28;13:834144. Epub 2022 Apr 28.

Department of Pharmacy, The First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, China.

Chronic glomerulonephritis (CGN) is one of the leading causes of end-stage renal disease (ESRD). A growing body of literature emphasizes the important role of long non-coding RNAs (lncRNAs) in the development and progression of the disease. However, the function of NONRATG001910. Read More

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Value of Neutrophil-Lymphocyte and Platelet-Lymphocyte Ratios in the Evaluation of Acute Rejection and Chronic Allograft Nephropathy in Children With Kidney Transplantation.

Exp Clin Transplant 2022 May;20(Suppl 3):129-136

From the Department of Pediatrics, Gazi University, Ankara, Turkey.

Objectives: Neutrophil-to-lymphocyte ratio and platelet (thrombocyte)-to-lymphocyte ratio have become accepted markers of inflammation in recent years and are used to assess disease activity in some diseases. In this study, we investigated the relationship between these values and acute rejection attacks, as well as their role in determining chronic allograft nephropathy, in follow-up of pediatric kidney transplant recipients.

Materials And Methods: Our study included 58 kidney transplant recipients (age 5-18 years) with at least 5-year follow-up at our center. Read More

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Clinical and histological findings at second but not at first kidney biopsy predict end-stage kidney disease in a large multicentric cohort of patients with active lupus nephritis.

Lupus Sci Med 2022 May;9(1)

Unit of Rheumatology, Department of Medicine, DIMED, University of Padua, Padova, Italy.

Objective: To investigate second kidney biopsy as predictor of end-stage kidney disease (ESKD) in active lupus nephritis (LN).

Methods: Patients with biopsy-proven LN (International Society of Nephrology/Renal Pathology Society 2003) who had undergone a second kidney biopsy between January 1990 and December 2018 were included. Clinical and histological findings at first and at second biopsy were analysed with Cox proportional hazard models to predict ESKD, defined as start of kidney replacement therapy. Read More

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Exposure of female NZBWF1 mice to imiquimod-induced lupus nephritis at an early age via a unique mechanism that differed from spontaneous onset.

Clin Exp Immunol 2022 May;208(1):33-46

Institute for Environment and Gender-Specific Medicine, Juntendo University Graduate School of Medicine, Chiba 279-0021, Japan.

Systemic lupus erythematosus (SLE) is a chronic inflammatory and representative autoimmune disease. Extremely complicated and multifactorial interactions between various genetic factors and individual susceptibility to environmental factors are involved in the pathogenesis of SLE. Several studies have reported that mutation and activation of toll-like receptor (TLR) 7 are involved in the onset of autoimmunity, including SLE. Read More

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Immune complex-mediated glomerulonephritis post COVID-19 vaccination in a patient with concomitant Brucellosis.

Saudi Med J 2022 May;43(5):522-525

From the Internal Medicine and Rheumatology, Prince Sultan Military Medical City, Riyadh, Kingdom of Saudi Arabia.

COVID vaccinations have been an important step in controlling the COVID-19 pandemic. Despite the fact they were generally safe and effective, a few case reports of renal disorders have been published following COVID vaccines. We report a 29-year-old man with history of Chronic Kidney Disease who presented to our center with flank pain after receiving AstraZeneca COVID vaccine. Read More

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Assessment of kidney involvement in systemic sclerosis: from scleroderma renal crisis to subclinical renal vasculopathy.

Am J Med Sci 2022 May 7. Epub 2022 May 7.

Department of Translational and Precision Medicine, Sapienza University of Rome. Electronic address:

The spectrum of kidney involvement in systemic sclerosis (SSc) includes scleroderma renal crisis, widely recognized as the most severe renal-vascular complication, but also several forms of chronic renal vasculopathy and reduced renal function are complications of scleroderma. Scleroderma renal crisis, myeloperoxidase-antineutrophil cytoplasmic antibody associated glomerulonephritis, penicillamine-associated renal disease, abnormal urinalysis, alteration of vascular endothelial markers, scleroderma associated-vasculopathy with abnormal renal resistance indices and cardiorenal syndromes type 5 were also reported in SSc patients. A frequent form of renal involvement in SSc patients is a subclinical renal vasculopathy, characterized by vascular damage and normal renal function. Read More

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Chronic renal failure in the brazzaville university hospital center: Epidemiological, clinical and evolutionary aspects.

Saudi J Kidney Dis Transpl 2021 Sep-Oct;32(5):1450-1455

Department of Nephrology, Brazzaville University Hospital, Brazzaville, Congo.

Chronic kidney disease (CKD) is a major global public health problem today. In Congo, we have very little epidemiological data. Our goal is to describe the epidemiological, clinical, therapeutic, and progressive aspects of IRC in Brazzaville. Read More

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Nephrotic syndrome in elderly: Etiologies, management, and prognosis.

Saudi J Kidney Dis Transpl 2021 Sep-Oct;32(5):1388-1396

Department of Nephrology, Dialysis and Transplantation, Charles Nicolle Hospital; Faculty of Medicine of Tunis, University of Tunis El Manar, Tunis, Tunisia.

The elderly population has significantly increased in the world. Nephrotic syndrome (NS) is one manifestation of glomerular nephropathy in the elderly. The objective of our study is to determine NS particularities in the elderly and to identify the factors predicting progression to chronic end-stage renal disease (ESRD). Read More

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A Case of Seronegative Full-house Nephropathy with Crohn's Disease.

Intern Med 2022 May 7. Epub 2022 May 7.

Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, Japan.

Systemic lupus erythematosus (SLE) is a chronic autoimmune inflammatory disease. Lupus nephritis (LN) is a major risk factor for mortality in SLE, and glomerular "full-house" immunofluorescence staining is a well-known characteristic of LN. However, some cases of non-lupus glomerulonephritis can also present with a "full-house" immunofluorescence pattern. Read More

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One-third of patients with lupus nephritis classified as complete responders continue to accrue progressive renal damage despite resolution of proteinuria.

Lupus Sci Med 2022 Apr;9(1)

Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA

Objective: Treatment response in lupus nephritis (LN) is defined based on proteinuria, yet protocol kidney biopsy studies have shown that patients with lupus can have active nephritis in the absence of proteinuria. Using estimated glomerular filtration rate (eGFR) trajectories, we characterised early chronic kidney disease in LN and examined whether certain patients continue to accrue renal damage despite proteinuric response.

Methods: We conducted a single-centre study of patients diagnosed with their first episode of biopsy-proven class III, IV, and/or V LN (n=37). Read More

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The Added Value of Crescents on Oxford Classification Score in Risk Stratification of End-stage Kidney Disease in Patients with IgA Nephropathy.

Iran J Kidney Dis 2022 Mar;16(2):115-124

Department of Medicine, Nephrology section), Iran University of Medical Sciences (IUMS), Hasheminejad Kidney Center (HKC), Tehran, Iran.

Introduction: Crescents (C) have been recently added to the Oxford classification of IgA nephropathy (IgAN) consisting of mesangial hypercellularity (M), endocapillary hypercellularity (E), segmental sclerosis (S) and tubular atrophy/ interstitial fibrosis (T) (MEST). The aim of the study was to assess the added impact of crescents, on development of end-stage kidney disease (ESKD) in IgAN patients Methods. On-hundred fifteen IgAN patients (76% male, mean age: 37 ± 13 years, mean serum creatinine: 4. Read More

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Paediatric Dialysis at a Tertiary Hospital in South-West Nigeria: A 4-Year Report.

Blood Purif 2022 Apr 28:1-7. Epub 2022 Apr 28.

Division of Pediatric Nephrology, Department of Pediatrics, Alberta Children's Hospital, University of Calgary, Calgary, Alberta, Canada.

Introduction: Dialysis is potentially lifesaving in children with acute kidney injury (AKI) or chronic kidney disease (CKD), but availability is limited in low-income countries and lower-middle-income countries (LMICs).

Methods: In the present study, we perform a 4-year study of patients who received peritoneal dialysis (PD) or haemodialysis (HD) at the Paediatric Nephrology Unit of the University College Hospital Ibadan, Nigeria. Subgroup analysis was performed on patients with sepsis or malaria AKI who underwent HD or PD for predictors of in-hospital mortality. Read More

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MiR-145 participates in the development of lupus nephritis by targeting CSF1 to regulate the JAK/STAT signaling pathway.

Cytokine 2022 Jun 22;154:155877. Epub 2022 Apr 22.

Department of Dermatology, Hainan Provincial Hospital of Skin Disease, 33 LongKun-Nan Road, Haikou 570206, Hainan Province, China. Electronic address:

Background: Lupus nephritis (LN) is a chronic autoimmune disease, leading to progressive renal dysfunction. MicroRNAs (miRNAs) contribute to LN pathophysiology. Nevertheless, the potential mechanisms of miR-145 in LN remain unclear. Read More

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Rhein Inhibits NF-B Signaling Pathway to Alleviate Inflammatory Response and Oxidative Stress of Rats with Chronic Glomerulonephritis.

Appl Bionics Biomech 2022 13;2022:9671759. Epub 2022 Apr 13.

Department of Traditional Chinese Medicine, The Affiliated Huaian NO.1 People's Hospital of Nanjing Medical University, Huaian City, Jiangsu Province 223300, China.

Objective: To explore the effect and mechanism of rhein on chronic glomerulonephritis (CGN).

Method: Twenty-four eight-week-old male SD rats were randomly divided into following 4 groups (6 rats in each group): control group, CGN group, rhein group, and benazepril (Ben) group. And 5 mg/mL of cationization-bovine serum albumin (C-BSA) was mixed with an equal volume of Freund's incomplete adjuvant for the preparation of 2. Read More

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IFI16 induces inflammation in hepatitis B virus-associated glomerulonephritis by regulating the Caspase-1/ IL-1 ß pathway.

Diagn Pathol 2022 Apr 23;17(1):39. Epub 2022 Apr 23.

Department of Liver Diseases, Shandong Public Health Clinical Center, Shandong University, Jinan, 250000, China.

Aims And Background: IFI16 plays an important role in innate immunity against invasive microbial infection by sensing double-stranded DNA viruses due to caspase-1-dependent inflammasome activation and subsequent maturation and secretion of IL-1β. However, the role of IFI16 in regulating the immune response to viruses in Hepatitis B Virus-Associated Glomerulonephritis (HBV-GN), especially in sensing hepatitis B virus (HBV), has not been determined. In this study, we investigated the inflammatory role of IFI16 in HBV-GN. Read More

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T Helper 2-Associated Immunity in the Pathogenesis of Systemic Lupus Erythematosus.

Front Immunol 2022 4;13:866549. Epub 2022 Apr 4.

Department of Life Sciences, Pohang University of Science and Technology, Pohang, South Korea.

Systemic Lupus Erythematosus (SLE) is a chronic autoimmune disease that mainly affects women in their reproductive years. A complex interaction of environmental and genetic factors leads to the disruption of immune tolerance towards self, causing overt immune activation and production of autoantibodies that attack multiple organs. Kidney damage, termed lupus nephritis, is the leading cause of SLE-related morbidity and mortality. Read More

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Spectrum of Non diabetic kidney disease in patients with type 2 diabetes and its clinicopathological correlation.

J Assoc Physicians India 2022 Apr;70(4):11-12

Sms Medical College and Hospital, Jaipur.

Diabetes mellitus (DM) is the leading cause of chronic kidney disease worldwide chiefly attributable to diabetic nephropathy (DN). In these patients, non diabetic kidney disease (NDKD) can also occur either alone or superimposed on diabetic nephropathy. This study aimed to identify the prevalence and the etiology of NDKD in our center and also the clinical and laboratory parameters to help distinguish these two entities. Read More

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Deceased Donor Renal Transplantation: 6 Year Experience from a Tertiary Care Center in North India.

J Assoc Physicians India 2022 Apr;70(4):11-12

Sms Medical College and Hospital, New Delhi.

The incident of End stage renal disease (ESRD) is rising rapidly worldwide. Renal transplant is the best modality of treatment, offering a better quality of life and mortality benefit, as compared with long-term dialysis. Very few patients have a live renal transplant donor, for rest, a decreased donor renal transplant is the only alternative. Read More

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Clinical Characteristics of Patients with Ckd Crash Landing and Initiating Dialysis…… Is it Time for Mandatory Screening Programme for Detection of CKD?

J Assoc Physicians India 2022 Apr;70(4):11-12

Sms Medical College, Jaipur.

The present study was undertaken to study clinical, biochemical and echocardiographic characteristics of patients with Chronic Kidney Disease crash- landing and initiating hemodialysis at first presentation in our centre.

Material: Ours was a cross-sectional study of one hundred and seventy patients with chronic kidney disease starting hemodialysis. Detailed history and examination were done. Read More

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Diverse and atypical manifestations of Q fever in a metropolitan city hospital: Emerging role of next-generation sequencing for laboratory diagnosis of Coxiella burnetii.

PLoS Negl Trop Dis 2022 04 20;16(4):e0010364. Epub 2022 Apr 20.

Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China.

Although Q fever has been widely reported in the rural areas of China, there is a paucity of data on the epidemiology and clinical characteristics of this disease in large metropolitan cities. In this study, we profile the epidemiology and clinical manifestations of Q fever from a tertiary hospital in Shenzhen, a Southern Chinese metropolitan city with a large immigrant population from other parts of China. A total of 14 patients were confirmed to have Q fever during a nine-year-and-six-month period, five of whom were retrospectively diagnosed during case review or incidentally picked up because of another research project on unexplained fever without localizing features. Read More

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Epidermal growth factor deficiency predisposes to progressive renal disease.

FASEB J 2022 05;36(5):e22286

Department of Dermatology, Cutaneous Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, USA.

Epidermal growth factor (EGF) is produced in the kidney by thick ascending limbs of the loop of Henle and by distal convoluted tubules (DCTs). Reduced urinary EGF levels have been associated with chronic kidney disease but it is not known whether physiological levels of EGF protect the kidney from progressive renal disease. Here, we show that EGF-deficient mice on a mixed genetic background had increased urinary microalbumin, and a subset of these mice developed severe progressive renal disease with azotemia that was not seen in WT or TGFα-deficient littermates with this mixed genetic background. Read More

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