7,946 results match your criteria Glomerulonephritis Acute


Granulicatella Causing Infective Endocarditis and Glomerulonephritis.

IDCases 2020 11;21:e00792. Epub 2020 May 11.

Department of Nephrology, UConn Health Center, Farmington, CT, United States.

Granulicatella is a type of nutritionally variant Streptococcus (NVS) that requires special medium for growth. It has shown to cause infective endocarditis which is associated with higher mortality and complications. We present a case of Granulicatella causing endocarditis and glomerulonephritis. Read More

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http://dx.doi.org/10.1016/j.idcr.2020.e00792DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7256654PMC

Nivolumab-induced IgA nephropathy in a patient with advanced gastric cancer: A case report.

Medicine (Baltimore) 2020 May;99(21):e20464

Department of Nephrology, Rheumatology, Endocrinology and Metabolism.

Introduction: Immune checkpoint inhibitors including nivolumab, an antibody against programmed death-1, have been increasingly introduced in various cancer treatment regimens, and are reported to be associated with immune-related adverse events. Nivolumab-induced renal injury is generally caused by acute interstitial nephritis and is managed by drug discontinuation and steroid therapy. Although this agent can infrequently induce glomerulonephritis, the pathogenesis and therapeutic strategy remain undetermined. Read More

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http://dx.doi.org/10.1097/MD.0000000000020464DOI Listing

Positron emission tomography imaging of renal mitochondria is a powerful tool in the study of acute and progressive kidney disease models.

Kidney Int 2020 Mar 28. Epub 2020 Mar 28.

Nephrology Research Laboratories, Kyowa Kirin Co., Ltd., Shizuoka, Japan.

Mitochondrial dysfunction plays a critical role in the pathogenesis of kidney diseases via ATP depletion and reactive oxygen species overproduction. Nonetheless, few studies have reported the renal mitochondrial status clinical settings, partly due to a paucity of methodologies. Recently, a positron emission tomography probe, F-BCPP-BF, was developed to non-invasively visualize and quantitate the renal mitochondrial status in vivo. Read More

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http://dx.doi.org/10.1016/j.kint.2020.02.024DOI Listing

Glomerular Diseases Associated with Malignancies: Histopathological Pattern and Association with Circulating Autoantibodies.

Antibodies (Basel) 2020 May 25;9(2). Epub 2020 May 25.

Nephrology Department & Transplantation Unit, Faculty of Medicine, Laiko Hospital, National & Kapodistrian University of Athens, 11527 Athens, Greece.

Aim: Glomerular diseases (GD) associated with malignancies (AM, GDAM) have unique features, which are important to recognize, in the light of the progress made in cancer therapy. We aimed to describe the clinical and histopathological characteristics of patients with GDAM in relation to the presence of circulating autoantibodies, pointing to potential immune pathogenic pathways connecting cancer to GD.

Materials And Methods: The included patients were studied retrospectively on the basis of a kidney biopsy proving GD and a related biopsy to establish the diagnosis of AM. Read More

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http://dx.doi.org/10.3390/antib9020018DOI Listing

Clinicopathologic features of infection-related glomerulonephritis with IgA deposits: a French Nationwide study.

Diagn Pathol 2020 May 27;15(1):62. Epub 2020 May 27.

Université de Tours, PRES Centre-Val de Loire, Tours, France.

Background: Infection-related glomerulonephritis with IgA deposits (IRGN-IgA) is a rare disease but it is increasingly reported in the literature. Data regarding epidemiology and outcome are lacking, especially in Europe. We aimed to assess the clinical, pathologic and outcome data of IRGN-IgA. Read More

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http://dx.doi.org/10.1186/s13000-020-00980-6DOI Listing

Primary antiphospholipid syndrome associated with anti-phospholipase A2 receptor antibody-positive membranous nephropathy.

BMC Nephrol 2020 May 24;21(1):196. Epub 2020 May 24.

Nephrology, dialysis and apheresis unit, University of Montpellier-Nimes, CHU de Nîmes, Rue du Professeur Robert Debré, Nîmes, France.

Background: The kidney is a major target in primary antiphospholipid syndrome. Several types of nephropathy have been reported, the most frequent being acute or chronic specific vascular nephropathies and membranous nephropathy.

Case Presentation: A 59-year-old male presented in our unit with nephrotic syndrome. Read More

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http://dx.doi.org/10.1186/s12882-020-01856-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7247250PMC

Recommendations for the management of patients with immune-mediated kidney disease during the severe acute respiratory syndrome coronavirus 2 pandemic.

Nephrol Dial Transplant 2020 May 23. Epub 2020 May 23.

Division of Diagnostics and Specialist Medicine, Department of Health, Medicine and Caring Sciences, Linköping University, Linköping, Sweden.

The coronavirus disease 2019 (COVID-19) pandemic has created major challenges for all countries around the globe. Retrospective studies have identified hypertension, cardiovascular disease, diabetes and older age as risk factors for high morbidity and mortality from COVID-19. There is a general concern that patients with immune-mediated kidney diseases, namely those on immunosuppressive therapies and/or those with more advanced kidney failure, could particularly be at risk for adverse outcomes due to a compromised antiviral immunity. Read More

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http://dx.doi.org/10.1093/ndt/gfaa112DOI Listing

Antibody-mediated rejection with the presence of glomerular crescents in a pediatric kidney transplant recipient: A case report.

Pediatr Transplant 2020 May 21:e13722. Epub 2020 May 21.

Pediatric Nephrology Department, Panagiotis & Aglaia Kyriakou Children's Hospital, Athens, Greece.

Glomerular crescents in kidney transplantation are indicative of severe glomerular injury and constitute a hallmark of RPGN. Their concurrence with ABMR has been rarely described only in adult patients. We report a case of 10-year-old boy with compound heterozygous Fin-major Finnish-type congenital nephrotic syndrome, who had received a deceased-donor kidney transplant 5 years before onset of acute kidney injury and nephrotic range proteinuria without hematuria. Read More

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http://dx.doi.org/10.1111/petr.13722DOI Listing

Case of Gut Necrosis in Adult-Onset Immunoglobulin A Vasculitis (Henoch-Schönlein Purpura).

J Investig Med High Impact Case Rep 2020 Jan-Dec;8:2324709620925565

Medical College of Georgia at Augusta University, Augusta, GA, USA.

Immunoglobulin A vasculitis (IgAV), formerly known as Henoch-Schönlein purpura, is an immune-mediated small vessel vasculitis characterized by palpable purpura, arthralgia, abdominal pain, and renal disease. It is primarily a childhood disease and usually resolves spontaneously with supportive therapy. Treatment of IgAV in adults is controversial with no clearly established guidelines. Read More

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http://dx.doi.org/10.1177/2324709620925565DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7243385PMC

Incidence of Acute Post-Streptococcal Glomerulonephritis in Hawai'i and Factors Affecting Length of Hospitalization.

Hawaii J Health Soc Welf 2020 May;79(5):149-152

Department of Pediatrics, John A Burns School of Medicine, University of Hawai'i, Honolulu, HI (BL-C, JM, RL, LN, DK).

Acute post-streptococcal glomerulonephritis (APSGN) is a disorder of inflammation in the glomeruli and vasculature of the kidneys that is caused by immune-complex formation after Streptococcus pyogenes infection. Most patients with APSGN present with macroscopic hematuria, edema, and hypertension, however presentation can vary from no symptoms to severe proteinuria, or even acute renal failure. This study sought to estimate the incidence of APSGN among children in Hawai'i, to identify populations at increased risk for APSGN, and to recognize risk factors correlated with the length of hospitalization by subtype of APSGN (eg, pyoderma-associated, pharyngitis-associated). Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7226310PMC

Ion-Channel modulator TH1177 reduces glomerular injury and serum creatinine in chronic mesangial proliferative disease in rats.

BMC Nephrol 2020 May 19;21(1):187. Epub 2020 May 19.

Renal Sciences, Department of Inflammation Biology, King's College London, Renal Medicine 10 Cutcombe Road, London, SE5 9RJ, UK.

Background: T-type calcium channels (TTCC) are involved in mesangial cell proliferation. In acute thy-1 nephritis in the rat TTCC inhibition reduces glomerular damage and cell proliferation. This work is extended here by a study of the non-selective TTCC inhibitor TH1177 in a chronic model of proliferative glomerulonephritis (GN) including late treatment starting after the initial inflammation has resolved. Read More

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http://dx.doi.org/10.1186/s12882-020-01842-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7236127PMC

Urinary Extracellular Vesicles as Biomarkers of Kidney Disease: From Diagnostics to Therapeutics.

Diagnostics (Basel) 2020 May 16;10(5). Epub 2020 May 16.

Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN 55905, USA.

Cell-derived extracellular vesicles (EVs) can be isolated from various body fluids, including urine. Urinary EVs have gained important recognition as potential diagnostic biomarkers in renal disease since their cargo includes nucleic acids, proteins, and other cellular components, which likely mirror the physiological and possibly pathophysiological state of cells along the nephron. Accumulating evidence highlights the feasibility of using EVs as biomarkers for diagnostic, prognostic, and therapeutic purposes in several forms of renal disease, such as acute kidney injury, glomerulonephritis, and renal transplantation. Read More

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http://dx.doi.org/10.3390/diagnostics10050311DOI Listing

Glomerulonephritis Histopathological Pattern Change.

BMC Nephrol 2020 May 18;21(1):186. Epub 2020 May 18.

Mubarak Al-Kabeer Hospital, Department of Internal Medicine, Nephrology Unit, Jabriya, Kuwait.

Background: Glomerulonephritides (GN) are relatively rare kidney diseases with substantial morbidity and mortality. They are often difficult to treat, sometimes with no cure, and can lead to chronic kidney disease (CKD) and end stage kidney disease (ESKD). Kidney biopsy is the diagnostic procedure of choice with variable indications from center to center. Read More

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http://dx.doi.org/10.1186/s12882-020-01836-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7236312PMC

Narrative Review of Hypercoagulability in Small-Vessel Vasculitis.

Kidney Int Rep 2020 May 13;5(5):586-599. Epub 2020 Jan 13.

Department of Internal Medicine, Section on Nephrology, Wake Forest School of Medicine, Winston Salem, North Carolina, USA.

Pauci-immune necrotizing and crescentic glomerulonephritis (GN) is the most common etiology of rapidly progressive GN. Clinical presentation in those afflicted is usually related to rapid loss of kidney function. We report the case of a 70-year-old woman who came to medical attention for signs and symptoms related to lower-extremity deep vein thrombosis (DVT). Read More

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http://dx.doi.org/10.1016/j.ekir.2019.12.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7210611PMC

Familial mediterranean fever and immunoglobulin A nephropathy: A case report and review of the literature.

Saudi J Kidney Dis Transpl 2020 Mar-Apr;31(2):537-541

Department of Nephrology, Ankara Numune Education and Research Hospital, Ankara, Turkey.

Familial Mediterranean fever (FMF) is an autosomal recessive disease charac-terized by recurrent fever episodes and polyserositis. The most important complication is amyloidosis. Nonamyloidotic nephropathy in FMF is poorly documented. Read More

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http://dx.doi.org/10.4103/1319-2442.284033DOI Listing

Atypical Anti-Glomerular Basement Membrane Disease With Diffuse Crescentic Membranoproliferative Glomerulonephritis: Case Report and Review of Literature.

Qatar Med J 2020 5;2020(1):16. Epub 2020 May 5.

Division of Nephrology, Department of Medicine, Hamad Medical Corporation, Doha, Qatar.

Anti-glomerular basement membrane (anti-GBM) disease occurs in fewer than two cases per million population. Patients usually present with features of rapidly progressive glomerulonephritis (RPGN) with or without pulmonary involvement. Anti-GBM disease is classically diagnosed by both demonstrating GBM linear immunofluorescence staining on kidney biopsy and detecting anti-GBM antibodies in serum. Read More

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http://dx.doi.org/10.5339/qmj.2020.16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7199789PMC

Effects of bodybuilding supplements on the kidney: A population-based incidence study of biopsy pathology and clinical characteristics among middle eastern men.

BMC Nephrol 2020 May 6;21(1):164. Epub 2020 May 6.

Department of Pathology, University of Sulaimani College of Medicine and Shoresh Teaching Hospital, Quirga Road, Sulaimani, Iraq.

Background: The incidence of kidney diseases among bodybuilders is unknown.

Methods: Between January 2011 and December 2019, the Iraqi Kurdistan 15 to 39 year old male population averaged 1,100,000 with approximately 56,000 total participants and 25,000 regular participants (those training more than 1 year). Annual age specific incidence rates (ASIR) with (95% confidence intervals) per 100,000 bodybuilders were compared with the general age-matched male population. Read More

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http://dx.doi.org/10.1186/s12882-020-01834-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7203829PMC

Kidney dendritic cells: fundamental biology and functional roles in health and disease.

Nat Rev Nephrol 2020 May 5. Epub 2020 May 5.

Division of Translational Immunology, III Medizinische Klinik, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany.

Dendritic cells (DCs) are chief inducers of adaptive immunity and regulate local inflammatory responses across the body. Together with macrophages, the other main type of mononuclear phagocyte, DCs constitute the most abundant component of the intrarenal immune system. This network of functionally specialized immune cells constantly surveys its microenvironment for signs of injury or infection, which trigger the initiation of an immune response. Read More

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http://dx.doi.org/10.1038/s41581-020-0272-yDOI Listing

Coxsackievirus B4 Exposure Results in Variable Pattern Recognition Response in the Kidneys of Female Non-obese Diabetic Mice Before Establishment of Diabetes.

Viral Immunol 2020 Apr 29. Epub 2020 Apr 29.

Interdisciplinary Program in Molecular and Cellular Biology, Ohio University, Athens, Ohio, USA.

End-stage renal disease (ESRD) is described by four primary diagnoses, diabetes, hypertension, glomerulonephritis, and cystic kidney disease, all of which have viruses implicated as causative agents. Enteroviruses, such as coxsackievirus (CV), are a common genus of viruses that have been implicated in both diabetes and cystic kidney disease; however, little is known about how CVs cause kidney injury and ESRD or predispose individuals with a genetic susceptibility to type 1 diabetes (T1D) to kidney injury. This study evaluated kidney injury resulting from coxsackievirus B4 (CVB4) inoculation of non-obese diabetic (NOD) mice to glean a better understanding of how viral exposure may predispose individuals with a genetic susceptibility to T1D to kidney injury. Read More

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http://dx.doi.org/10.1089/vim.2019.0188DOI Listing

Recent Advances in Pathology: the 2020 Annual Review Issue of The Journal of Pathology.

J Pathol 2020 Apr;250(5):475-479

RECAMO, Masaryk Memorial Cancer Institute, Brno, Czech Republic.

This year's Annual Review Issue of The Journal of Pathology contains 18 invited reviews on current research areas in pathology. The subject areas reflect the broad range of topics covered by the journal and this year encompass the development and application of software in digital histopathology, implementation of biomarkers in pathology practice; genetics and epigenetics, and stromal influences in disease. The reviews are authored by experts in their field and provide comprehensive updates in the chosen areas, in which there has been considerable recent progress in our understanding of disease. Read More

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http://dx.doi.org/10.1002/path.5425DOI Listing

Mechanism of Chronic Kidney Disease Progression and Novel Biomarkers: A Metabolomic Analysis of Experimental Glomerulonephritis.

Metabolites 2020 Apr 24;10(4). Epub 2020 Apr 24.

Kidney Research Institute, Seoul National University College of Medicine, Seoul 03080, Korea.

While a complex network of cellular and molecular events is known to be involved in the pathophysiological mechanism of chronic kidney disease (CKD), the divergence point between reversal and progression and the event that triggers CKD progression are still unknown. To understand the different mechanisms between reversible and irreversible kidney disease and to search for urinary biomarkers that can predict prognosis, a metabolomic analysis was applied to compare acute and chronic experimental glomerulonephritis (GN) models. Four metabolites, namely, epoxyoctadecenoic acid (EpOME), epoxyeicosatetraenoic acid (EpETE), α-linolenic acid (ALA), and hydroxyretinoic acid, were identified as predictive markers after comparing the chronic nephritis model with acute nephritis and control groups (false discovery rate adjusted -value (q-value) < 0. Read More

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http://dx.doi.org/10.3390/metabo10040169DOI Listing

The association between renal function and BMD response to bisphosphonate treatment: Real-world cohort study using linked national registers.

Bone 2020 Apr 22;137:115371. Epub 2020 Apr 22.

Dept. of Endocrinology, Odense University Hospital, DK-5000 Odense C, Denmark.

Background: Management of osteoporosis given reduced renal function is one of the largest challenges in the bone clinic.

Objectives: Identify the cut-off for renal function below which there would be no overall BMD benefit associated with bisphosphonate use. Track safety outcomes resulting in hospital encounters. Read More

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http://dx.doi.org/10.1016/j.bone.2020.115371DOI Listing

Development of de novo HLA donor specific antibodies (HLA-DSA), HLA antibodies (HLA-Ab) and allograft rejection post blood transfusion in kidney transplant recipients.

Hum Immunol 2020 Apr 20. Epub 2020 Apr 20.

Central Northern Adelaide Renal and Transplant Services (CNARTS), Royal Adelaide Hospital, 5000 Adelaide, SA, Australia; South Australian Transplantation and Immunogenetics Laboratory, Women's and Children's Hospital, 5006 North Adelaide, SA, Australia. Electronic address:

Background: Blood transfusion during the post-operative period of kidney transplantation is common as part of a life-saving procedure, especially in the event of acute blood loss. However, there have been conflicting opinions since the pre-cyclosporine era. The risk of sensitization post-transfusion remains the main limiting factor following transfusion in kidney transplant recipients. Read More

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http://dx.doi.org/10.1016/j.humimm.2020.04.002DOI Listing

Granulomatosis with Polyangiitis and Acute Tubulointerstitial Nephritis in the Absence of Glomerulonephritis.

Am J Med 2020 Apr 20. Epub 2020 Apr 20.

Department of Renal Medicine, Singapore General Hospital. Electronic address:

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http://dx.doi.org/10.1016/j.amjmed.2020.03.024DOI Listing

The Presence of Renal IgG Deposits in Necrotizing Crescentic Glomerulonephritis Associated with ANCA Is Not Related to Worse Renal Clinical Outcomes.

Kidney Dis (Basel) 2020 Mar 21;6(2):98-108. Epub 2019 Nov 21.

Department of Nephrology - Hypertension, Dialysis, Transplantation, CHRU, Tours, France.

Introduction: Classical pauci-immune necrotizing crescentic glomerulonephritis (CGN) associated with antineutrophil cytoplasmic autoantibodies (ANCA) is characterized by the absence of renal immunoglobulin (Ig) deposits. However, IgG deposits can sometimes be present. We wanted to assess whether necrotizing CGN with IgG deposits is associated with a more severe presentation and outcome than necrotizing CGN without IgG deposits. Read More

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http://dx.doi.org/10.1159/000503969DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7154286PMC

Renal Toxicity.

Adv Exp Med Biol 2020 ;1244:287-293

Division of Internal Medicine, Section of Nephrology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

With the increasing use of immunotherapy, there has been an associated increased survival in many cancers but has also resulted in unregulated organ-specific toxicities. In this chapter, we discuss the renal toxicities associated with a checkpoint inhibitor (CPI) from the typical acute tubulointersitial nephritis to glomerulonephritis, their proposed mechanisms, and treatments. We also discuss the use of CPI and reactivation of preexisting auto-immune diseases and focus on renal cell cancer in setting of Chronic kidney disease (CKD). Read More

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http://dx.doi.org/10.1007/978-3-030-41008-7_16DOI Listing
January 2020

Human leucocyte antigen-associated anti-glomerular basement membrane disease in siblings.

Clin Kidney J 2020 Apr 3;13(2):261-262. Epub 2019 Jun 3.

Department of Renal Medicine, Royal Preston Hospital, Preston, UK.

We report a case of anti-glomerular basement membrane (GBM) disease in association with human leucocyte antigen (HLA) DRB1 15:01. A 71-year-old woman presented with oligoanuric acute kidney injury accompanied by high titre anti-GBM antibodies. Renal biopsy revealed a severe crescentic glomerulonephritis. Read More

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http://dx.doi.org/10.1093/ckj/sfz058DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7147311PMC

Hydralazine-induced antineutrophil cytoplasmic antibody-associated vasculitis with pulmonary-renal syndrome: a case report.

J Med Case Rep 2020 Apr 15;14(1):47. Epub 2020 Apr 15.

Section of Critical Care, Department of Medicine, Saint Agnes Hospital, Baltimore, MD, USA.

Background: Hydralazine is a common vasodilator which has been used for the treatment of hypertension and heart failure. Hydralazine can induce antineutrophil cytoplasmic antibody-associated vasculitis due to its auto-immunogenic capability and one of the very rare presentations is pulmonary-renal syndrome.

Case Presentation: We report a case of a 64-year-old African American woman, who presented to our emergency room with shortness of breath, orthopnea, paroxysmal nocturnal dyspnea, leg swelling, fatigue, loss of appetite, cough with clear sputum, and lightheadedness. Read More

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http://dx.doi.org/10.1186/s13256-020-02378-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7158156PMC

Anti-glomerular basement membrane disease complicated with posterior reversible encephalopathy syndrome and subcortical cerebral hemorrhage: a case report and review of the literature.

CEN Case Rep 2020 Apr 10. Epub 2020 Apr 10.

Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-Ku, Fukuoka, 8128582, Japan.

A 71-year-old woman was hospitalized for the treatment of fatigue, fever, and cough. On admission, she showed increased serum inflammation markers, severe anemia, pulmonary hemorrhage, and advanced acute kidney injury requiring hemodialysis. Her serum anti-glomerular basement membrane (GBM) antibody titer was found to be extremely high on the 7th hospital day. Read More

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http://dx.doi.org/10.1007/s13730-020-00473-xDOI Listing

Glomerular Deposition of Nephritis-Associated Plasmin Receptor (NAPlr) and Related Plasmin Activity: Key Diagnostic Biomarkers of Bacterial Infection-related Glomerulonephritis.

Int J Mol Sci 2020 Apr 8;21(7). Epub 2020 Apr 8.

Kidney Disease Center, Department of Nephrology and Blood Purification, Tokyo Medical University Hachioji Medical Center, Hachioji, Tokyo 193-0998, Japan.

It is widely known that glomerulonephritis (GN) often develops after the curing of an infection, a typical example of which is GN in children following streptococcal infections (poststreptococcal acute glomerulonephritis; PSAGN). On the other hand, the term "infection-related glomerulonephritis (IRGN)" has recently been proposed, because infections are usually ongoing at the time of GN onset in adult patients, particularly in older patients with comorbidities. However, there has been no specific diagnostic biomarker for IRGN, and diagnosis is based on the collection of several clinical and pathological findings and the exclusion of differential diagnoses. Read More

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http://dx.doi.org/10.3390/ijms21072595DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7178002PMC

The Effect of Low-Power Laser Therapy on the TGF/β Signaling Pathway in Chronic Kidney Disease: A Review.

J Lasers Med Sci 2020 15;11(2):220-225. Epub 2020 Mar 15.

Laser Application in Medical Sciences Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

The purpose of this study is to investigate the effects of low-power lasers on kidney disease by investigating several studies. A number of articles from 1998 to 2019 were chosen from the sources of PubMed, Scopus, and only the articles studying the effect of low-power lasers on kidney disease were investigated. After reviewing the literature, 21 articles examining only the effects of low-power lasers on kidney disease were found. Read More

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http://dx.doi.org/10.34172/jlms.2020.36DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7118498PMC

Pharyngitis: Approach to diagnosis and treatment.

Can Fam Physician 2020 Apr;66(4):251-257

Assistant Professor and Research Director in the Department of Otolaryngology at Queen's University and Adjunct Scientist with ICES Queen's.

Objective: To provide family physicians with an updated approach to diagnosis and treatment of pharyngitis, detailing key symptoms, methods of investigation, and a summary of common causes.

Sources Of Information: The approach described is based on the authors' clinical practice and peer-reviewed literature from 1989 to 2018.

Main Message: Sore throat caused by pharyngitis is commonly seen in family medicine clinics and is caused by inflammation of the pharynx and surrounding tissues. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7145142PMC

Membranoproliferative Glomerulonephritis Associated with Nivolumab Therapy.

Case Rep Nephrol 2020 24;2020:2638283. Epub 2020 Feb 24.

Department of Internal Medicine, Division of Nephrology, University of California at Davis, Sacramento, CA, USA.

Nivolumab is an immune checkpoint inhibitor that targets programmed death-1 on T cells and is designed to amplify an immunologic reaction against cancer cells. However, upregulation of the immune system with checkpoint inhibition is nonspecific, and it can be associated with certain renal side effects, the best documented of which is acute tubulointerstitial nephritis. We present a unique case of a patient with acute kidney injury associated with nephrotic syndrome shortly after starting nivolumab therapy for metastatic anal carcinoma. Read More

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http://dx.doi.org/10.1155/2020/2638283DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7060432PMC
February 2020

Influenza a H1N1 associated acute glomerulonephritis in an adolescent.

IDCases 2020 15;19:e00659. Epub 2019 Oct 15.

Department of Pediatrics, Thriasio General Hospital, Athens, Greece.

Influenza virus primarily affects the respiratory system. It rarely causes extrapulmonary complications, with otitis media and febrile seizures being the most common in children. Acute glomerulonephritis as a complication of H1N1 influenza virus infection has been described only sporadically. Read More

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http://dx.doi.org/10.1016/j.idcr.2019.e00659DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7093738PMC
October 2019

Trends in premature avertable mortality from non-communicable diseases for 195 countries and territories, 1990-2017: a population-based study.

Lancet Glob Health 2020 Apr;8(4):e511-e523

London School of Hygiene & Tropical Medicine, London, UK.

Background: The reduction by a third of premature non-communicable disease (NCD) mortality by 2030 is the ambitious target of Sustainable Development Goal (SDG) 3.4. However, the indicator is narrowly defined, including only four major NCDs (cardiovascular diseases, cancer, diabetes, and chronic respiratory diseases) and only for people aged 30-70 years. Read More

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http://dx.doi.org/10.1016/S2214-109X(20)30035-8DOI Listing

[Infectious glomerulonephritis and pleuropneumonia due to Streptococcus pneumoniae. Pediatric clinical case].

Arch Argent Pediatr 2020 04;118(2):e208-e210

Unidad de Paciente Crítico Pediátrico, Hospital Clínico Metropolitano La Florida, Santiago, Chile.

Acute glomerulonephritis caused by Streptococcus pneumoniae is a low prevalence pathology. There are several reports communicating different nephritogenic serotypes, however, 6C has been scarcely indicated as such. It is presented the case of a 4-year-old patient who entered Intensive Therapy Unit with pleuropneumonia due to Streptococcus pneumoniae serotype 6C and concomitantly developed edemas, arterial hypertension, hematuria, proteinuria, decreased glomerular filtration rate and C3 complement level. Read More

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http://dx.doi.org/10.5546/aap.2020.e208DOI Listing

[Paradigm shift in understanding Acute kidney injury in patients with chronic liver disease: From pathophysiology to defining disease entities].

Z Gastroenterol 2020 Mar 20;58(3):254-266. Epub 2020 Mar 20.

Klinik für Nieren- und Hochdruckerkrankungen, Diabetologie und Endokrinologie, Medizinische Fakultät der Otto-von-Guericke-Universität, Magdeburg, Deutschland.

The hepatorenal syndrome (HRS) is only a part of the wide spectrum of renal injury in patients with end-stage liver cirrhosis. Besides that, the advanced liver disease itself, or its underlying causes, as well as comorbidities, like diabetes mellitus, adiposity and arterial hypertension, can directly cause parenchymal renal insults (bile acid nephropathy, ischemic tubular injury, diabetic/hypertensive nephropathy, hepatitis B- and C-associated glomerulonephritis etc.). Read More

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http://dx.doi.org/10.1055/a-1088-1582DOI Listing

[Successful rituximab treatment of recurrent glomerulonephritis associated with antibodies against the glomerular basement membrane].

Internist (Berl) 2020 Apr;61(4):416-423

Abteilung Nephrologie, Universitätsklinikum Regensburg, Franz-Josef-Strauß-Allee 11, 93053, Regensburg, Deutschland.

This article presents a case of recurrent anti-GBM disease (with antibodies against the glomerular basement membrane [GBM]) in a 17-year-old patient successfully treated with rituximab. Kidney biopsy with detection of linear deposition of immunoglobulin G (IgG) along the basement membrane is the diagnostic gold standard, which should be accompanied by serological testing. However, standard assays for the detection of anti-GBM antibodies have a high rate of false-negative results. Read More

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http://dx.doi.org/10.1007/s00108-020-00773-5DOI Listing

Disease and treatment-related morbidity in young and elderly patients with granulomatosis with polyangiitis and microscopic polyangiitis.

Semin Arthritis Rheum 2020 Feb 24. Epub 2020 Feb 24.

Department of Rheumatology, Santa Chiara Hospital, Trento, Italy.

Objective: Aging may be a risk factor for morbidity in anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). We compared the rate and better characterized the type of disease- and treatment-related complications affecting young and elderly patients with AAV.

Methods: All new cases of granulomatosis with polyangiitis or microscopic polyangiitis diagnosed in three referral centers between 2000-2016 were included. Read More

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http://dx.doi.org/10.1016/j.semarthrit.2020.02.008DOI Listing
February 2020

Rare case of post-varicella membranoproliferative glomerulonephritis presenting with massive proteinuria.

BMJ Case Rep 2020 Mar 12;13(3). Epub 2020 Mar 12.

Internal Medicine, King George's Medical University, Lucknow, Uttar Pradesh, India.

Chicken pox caused by varicella zoster virus is usually a self-limiting disease causing rare life-threatening complications. Involvement of the kidneys is infrequent during the course of the illness. Literature shows rare reports of acute glomerulonephritis following varicella infection. Read More

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http://dx.doi.org/10.1136/bcr-2019-233084DOI Listing

Symmetric polyneuropathy after viral symptomatology - not always Guillain-Barré Syndrome.

Acta Clin Belg 2020 Mar 13:1-8. Epub 2020 Mar 13.

Department of Nephrology, AZ St. Elisabeth Hospital, Zottegem, Belgium.

: Guillain-Barré Syndrome usually presents with ascending symmetric polyneuropathy, typically preceded by a viral infection. Despite the low incidence, physicians will often include Guillain-Barré Syndrome in their differential diagnosis. However, another underlying cause of polyneuropathy known as ANCA-associated vasculitis (AAV) is even more rare than Guillain-Barré Syndrome and therefore is usually overlooked. Read More

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http://dx.doi.org/10.1080/17843286.2020.1740858DOI Listing

An Unusual Case of Acquired Angioedema and Monoclonal Gammopathy of Renal Significance in a Middle-Aged Caucasian Female.

J Investig Med High Impact Case Rep 2020 Jan-Dec;8:2324709620912096

Lynchburg Nephrology Physicians, Lynchburg, VA, USA.

Acquired angioedema due to deficiency of C1 esterase inhibitor is also called acquired angioedema and is abbreviated as C1INH-AAE. It is a rare syndrome of recurrent episodes of angioedema, without urticaria, and in some patients, it is associated with B-cell lymphoproliferative disorders. Kidney involvement is rare in this condition. Read More

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http://dx.doi.org/10.1177/2324709620912096DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7074490PMC

Acute interstitial nephritis and drug-induced systemic lupus erythematosus due to chlorthalidone and amiodarone: A case report.

SAGE Open Med Case Rep 2020 1;8:2050313X20910029. Epub 2020 Mar 1.

Division of Nephrology, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.

Drug-induced lupus erythematosus has features distinct from primary systemic lupus erythematosus. It can occur with a wide variety of agents that result in the generation of anti-histone or other types of antibodies. Systemic manifestations of drug-induced systemic lupus erythematosus may include renal dysfunction due to circulating immune complexes or due to other immune reactions to the culprit medication(s). Read More

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http://dx.doi.org/10.1177/2050313X20910029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7052449PMC

[A report of six TAFRO syndrome: clinical characteristics, diagnosis and treatment analysis].

Zhonghua Yi Xue Za Zhi 2020 Mar;100(8):624-628

Department of Emergency Peking University People's Hospital, Beijing 100044, China.

To explore the clinical characteristics, treatment and prognosis of TAFRO syndrome. All patients diagnosed as Castleman disease in Peking University People's Hospital between December 2011 and April 2019 were included.Among them,6 patients were diagnosed as TAFRO syndrome. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0376-2491.2020.08.012DOI Listing

Therapeutic Potential of Thrombomodulin in Renal Fibrosis of Nephrotoxic Serum Nephritis in Wistar-Kyoto Rats.

Kidney Blood Press Res 2020 6;45(3):391-406. Epub 2020 Mar 6.

Division of Nephrology, Department of Medicine, Showa University School of Medicine, Tokyo, Japan.

Background: Recombinant human soluble thrombomodulin (rhTM) was approved in 2008 and has been used for treatment of disseminated intravascular coagulation in Japan. The antifibrotic effects of rhTM in acute exacerbation of idiopathic pulmonary fibrosis are well established, but the therapeutic potential of rhTM in renal fibrosis remains poorly understood.

Methods: Nephrotoxic serum nephritis (NTS-N) was induced in 22 female Wistar-Kyoto (WKY) rats on day 0. Read More

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http://dx.doi.org/10.1159/000506286DOI Listing

Acute Kidney Injury Without Previous Renal Disease in Critical Care Unit.

Pediatr Int 2020 Mar 7. Epub 2020 Mar 7.

Division of Nephrology, Department of Pediatrics, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand.

Background: Acute kidney injury (AKI) is common in hospitalized and critically ill children. Apart from primary kidney disease, etiologies of AKI are usually related to systemic disease and nephrotoxic insult. This study examines an incidence, characteristics and mortality risks of AKI in critically ill children without primary renal disease and previously known chronic kidney disease (CKD). Read More

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http://dx.doi.org/10.1111/ped.14218DOI Listing

Challenges in Understanding Acute Postinfectious Glomerulonephritis: Are Anti-Factor B Autoantibodies the Answer?

J Am Soc Nephrol 2020 Apr 6;31(4):670-672. Epub 2020 Mar 6.

Department of Rare Diseases, IRCCS-Istituto di Ricerche Farmacologiche Mario Negri, Bergamo, Italy.

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http://dx.doi.org/10.1681/ASN.2020020168DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7191934PMC

Curcumin Attenuates Both Acute and Chronic Immune Nephritis.

Int J Mol Sci 2020 Mar 4;21(5). Epub 2020 Mar 4.

Department of Biomedical Engineering, University of Houston, Houston, TX 77204, USA.

Curcumin is known to have immunomodulatory potential in addition to anti-oxidant, anti-inflammatory and anti-carcinogenic effects. The aim of the present study is to investigate the therapeutic effects of curcumin on immune-mediated renal disease in an anti-glomerular basement membrane (GBM) model (representing acute kidney Injury, AKI) and murine lupus model (representing chronic kidney disease, CKD). In the AKI model, female anti-GBM 129/svj mice were administered with curcumin right before disease induction. Read More

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http://dx.doi.org/10.3390/ijms21051745DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7084772PMC

Infection-related Glomerulonephritis and C3 Glomerulonephritis - Similar Yet Dissimilar: A Case Report and Brief Review of Current Literature.

Cureus 2020 Feb 28;12(2):e7127. Epub 2020 Feb 28.

Nephrology, Medical College of Wisconsin, Milwaukee, USA.

Infection-related glomerulonephritis (IRGN) is an immune complex-mediated glomerulonephritis (GN), often preceded by infection with subsequent recovery of renal function after the resolution of the infection. C3 deposition in the absence of immune complex deposits can be seen in patients with IRGN, but with the emergence of C3 glomerulonephritis (C3GN), the distinction is difficult as the clinical and pathological presentation may be similar. However, their treatment and clinical course vary significantly. Read More

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http://dx.doi.org/10.7759/cureus.7127DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7047932PMC
February 2020

Clinical Profile and Outcome of IgA Nephropathy from a Tertiary Care Hospital in North India.

J Assoc Physicians India 2020 Mar;68(3):20-22

Professor and Head, Departments of Nephrology, Indira Gandhi Medical College, Shimla, Himachal Pradesh; Corresponding Author.

Aim: To study the clinical profile and outcome of the patients with kidney biopsy diagnosis of IgA Nephropathy (IgAN).

Methods: A retrospective study of the patients diagnosed IgAN over a period of three and half years.

Results: Sixty (13. Read More

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