7,691 results match your criteria Glomerulonephritis Acute


Abnormal Chest Radiograph in Rapidly Progressive Glomerulonephritis - Not the Usual Pulmonary-Renal Syndrome.

Am J Med 2019 Apr 15. Epub 2019 Apr 15.

Department of Renal Medicine, Singapore General Hospital. Electronic address:

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http://dx.doi.org/10.1016/j.amjmed.2019.03.038DOI Listing
April 2019
1 Read

Cardiac Point-of-Care Ultrasound for the Diagnosis of Infective Endocarditis in a Patient with Non-Specific Rheumatologic Symptoms and Glomerulonephritis.

Am J Case Rep 2019 Apr 18;20:542-547. Epub 2019 Apr 18.

Weill Department of Medicine, Weill Cornell Medicine, New York City, NY, USA.

BACKGROUND Point-of-care ultrasound (POCUS) is performed at the bedside by a healthcare professional who is directly caring for the patient. Subacute infective endocarditis can be challenging to diagnose, as patients often present with non-specific symptoms. The modified Duke criteria include echocardiographic findings as a major criterion, but the role of POCUS has not been established. Read More

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https://www.amjcaserep.com/abstract/index/idArt/914708
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http://dx.doi.org/10.12659/AJCR.914708DOI Listing
April 2019
3 Reads

Estimating the Change in Renal Function During the First Year of Therapy in ANCA-Associated Vasculitis.

Kidney Int Rep 2019 Apr 13;4(4):594-602. Epub 2019 Feb 13.

Nephrology Division, Hôpital du Sacré-Coeur de Montréal, Québec, Canada.

Introduction: Studies in antineutrophil cytoplasmic autoantibody (ANCA)-associated vasculitis (AAV) consistently show that the months following diagnosis have the greatest impact on the long-term renal function. Yet, it remains uncertain how much early gain should be expected with treatment. We sought to determine the factors associated with the change in glomerular filtration rate (GFR) throughout the first year. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S24680249193004
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http://dx.doi.org/10.1016/j.ekir.2019.02.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451086PMC
April 2019
2 Reads

Multiple Faces of Chronic Lymphocytic Leukaemia: A Patient with Renal, Cardiac, and Skeletal Complications.

Case Rep Nephrol 2019 12;2019:5390235. Epub 2019 Mar 12.

Department of Renal Medicine, Norfolk and Norwich University Hospital, Norwich, UK.

We describe a patient who had chronic lymphocytic leukaemia (CLL) Binet stage A at presentation with further evidence of disease at multiple sites but who initially required no treatment. However, several years later, her peripheral blood lymphocyte count started to increase, and soon after that she suffered an acute myocardial infarct (in the absence of coronary atheroma) together with proteinuric renal failure due to membranoproliferative glomerulonephritis. Her renal function improved markedly following anti-CLL chemotherapy. Read More

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https://www.hindawi.com/journals/crin/2019/5390235/
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http://dx.doi.org/10.1155/2019/5390235DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434293PMC
March 2019
2 Reads

Renal histopathology of prolonged acute kidney injury in HELLP syndrome: a case series and literature review.

Int Urol Nephrol 2019 Apr 15. Epub 2019 Apr 15.

Department of Nephrology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shuifuyuan 1, Wangfujing, Beijing, 100730, China.

Purpose: Acute kidney injury (AKI) is a severe complication of hemolysis, elevated liver enzymes, and low platelet count (HELLP) syndrome. However, renal pathological investigation of AKI in this syndrome has rarely been reported. We aimed to evaluate the renal pathological changes of persistent AKI and its relationship with renal outcomes in HELLP syndrome. Read More

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http://dx.doi.org/10.1007/s11255-019-02135-zDOI Listing
April 2019
1 Read

IgA Nephropathy Flare-Up Mimicking Staphylococcus Post-Infection Glomerulonephritis in Patient with Staphylococcus Aureus Infection Treated with Cefazolin: A Case Report and Brief Review of the Literature.

Am J Case Rep 2019 Apr 12;20:508-510. Epub 2019 Apr 12.

Department of Pharmacy Services, Piedmont Columbus Regional Healthcare System, Columbus, GA, USA.

BACKGROUND Glomerulonephritis (GN) associated with post staphylococcus infection (PSIGN) and high serum immunoglobulin A (IgA) has been reported recently. Patients with GN after infection with underlying IgA nephropathy create a challenge to determine the etiology of GN. Therefore, treatment should be accordingly, with steroids used if the IgA nephropathy flare-up is determined to be the etiology. Read More

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http://dx.doi.org/10.12659/AJCR.914935DOI Listing
April 2019
5 Reads

Natural Killer Cells in Kidney Health and Disease.

Front Immunol 2019 26;10:587. Epub 2019 Mar 26.

Conjoint Kidney Research Laboratory, Chemical Pathology-Pathology Queensland, Brisbane, QLD, Australia.

Natural killer (NK) cells are a specialized population of innate lymphocytes that have a major effector function in local immune responses. While their immunological functions in many inflammatory diseases are well established, comparatively little is still known about their roles in kidney homeostasis and disease. Our understanding of kidney NK cells is rapidly evolving, with murine studies highlighting the functional significance of NK cells in acute and chronic forms of renal disease. Read More

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http://dx.doi.org/10.3389/fimmu.2019.00587DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443628PMC
March 2019
1 Read

[Preliminary study on the relationship between OSA and renal function].

Authors:
F Song H L Yi

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2019 Apr;33(4):298-303

Department of Otolaryngology Head and Neck Surgery,Shanghai Jiaotong University Affiliated Sixth People's Hospital,Otolaryngology Institute of Shanghai Jiaotong University, Shanghai, 200233, China.

To explore the relationship between obstructive sleep apnea(OSA) and renal function. We collected the clinical data of 487 patients who underwent sleep monitoring in our hospital from January 2013 to December 2017 and excluded history of chronic heart disease, acute and chronic glomerulonephritis, and pyelonephritis. Among the 487 patients, 54 were in nonOSA control group and 433 were in OSA group, including 64 patients with mild OSA, 77 patients with moderate OSA, 108 patients with severe OSA, and 188 patients with extremly severe OSA. Read More

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http://www.cnki.net/kcms/doi/10.13201/j.issn.1001-1781.2019.
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http://dx.doi.org/10.13201/j.issn.1001-1781.2019.04.004DOI Listing
April 2019
3 Reads

Cast nephropathy associated with monoclonal immunoglobulin M-secreting mucosa-associated lymphoid tissue B-cell lymphoma
.

Clin Nephrol 2019 Apr 9. Epub 2019 Apr 9.

The kidney is among the various anatomical sites involved in mucosa-associated lymphoid tissue (MALT) lymphoma. A variety of renal pathological types, including membranous glomerulopathy, membranoproliferative glomerulonephritis, crescentic IgA nephropathy, minimal change disease, and cryoglobulinemic glomerulopathy, have been reported in MALT lymphoma patients. However, cast nephropathy is extremely rare in MALT lymphoma. Read More

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http://dx.doi.org/10.5414/CN109682DOI Listing
April 2019
4 Reads

Recent advances in the immunological understanding of association between tonsil and immunoglobulin A nephropathy as a tonsil-induced autoimmune/inflammatory syndrome.

Immun Inflamm Dis 2019 Apr 7. Epub 2019 Apr 7.

Department of Otolaryngology-Head and Neck Surgery, Asahikawa Medical University, Asahikawa, Japan.

Introduction: Immunoglobulin A nephropathy (IgAN) is the most common form of primary glomerulonephritis worldwide. It is well known that upper respiratory tract infections, particularly acute tonsillitis, often worsen IgAN. Recent many clinical studies clearly show that tonsillectomy with steroid pulse therapy is the effective treatments for IgAN patients. Read More

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http://dx.doi.org/10.1002/iid3.248DOI Listing
April 2019
5 Reads

Rapidly Progressive Glomerulonephritis Secondary to IgA Nephropathy in a Patient with Systemic Lupus Erythematosus.

Case Rep Nephrol 2019 5;2019:8354823. Epub 2019 Mar 5.

Department of Internal Medicine, Division of Nephrology, Houston, TX, USA.

Lupus nephritis is a common manifestation of systemic lupus erythematosus (SLE). IgA nephropathy is a common type of primary glomerulonephritis. Renal manifestations in SLE patients are often due to lupus nephritis; however, renal diseases unrelated to lupus nephritis are rarely reported. Read More

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https://www.hindawi.com/journals/crin/2019/8354823/
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http://dx.doi.org/10.1155/2019/8354823DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425374PMC
March 2019
4 Reads

Membranous Nephropathy in a Patient with Human Immunodeficiency Virus Shortly After Initiation of HAART with Atripla.

Cureus 2019 Jan 21;11(1):e3932. Epub 2019 Jan 21.

Internal Medicine, Charleston Area Medical Center, Charleston, USA.

A human immunodeficiency virus (HIV) infection has long been associated with kidney disease. The pathogenesis of renal complications may be directly related to the presence of HIV viral particles or may occur secondary to an immune response against the virus. A number of HIV medications have been associated with the development of acute and chronic kidney disease. Read More

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http://dx.doi.org/10.7759/cureus.3932DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6430309PMC
January 2019
1 Read

La ponction biopsie rénale: indications, complications et résultats.

Pan Afr Med J 2018 20;31:44. Epub 2018 Sep 20.

Centre Hospitalier Universitaire Mohammed VI, Oujda, Maroc.

Renal needle biopsy (RNB) is the gold standard in the diagnosis of kidney diseases. It is an invasive technique causing several complications, in particular hemorrhagic events. This study aims to evaluate our RNB practice, to update the current understanding of the technique for percutaneous renal biopsy, to assess complications and to determine the prevalence of kidney diseases diagnosed in our region. Read More

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http://dx.doi.org/10.11604/pamj.2018.31.44.15604DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6430949PMC
April 2019
1 Read

Systematic Review of Group A Streptococcal Types Associated with Acute Post-Streptococcal Glomerulonephritis.

Am J Trop Med Hyg 2019 Mar 25. Epub 2019 Mar 25.

Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Victoria, Australia.

Acute post-streptococcal glomerulonephritis (APSGN) is a postinfectious immune-mediated kidney disease associated with group A (GAS). The prevalence of APSGN varies within and between countries and is influenced by socioeconomic, host, and bacterial factors. The disease is more prevalent in developing countries and resource-poor settings of developed countries, such as the Indigenous populations residing in tropical Australia. Read More

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http://www.ajtmh.org/content/journals/10.4269/ajtmh.18-0827
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http://dx.doi.org/10.4269/ajtmh.18-0827DOI Listing
March 2019
3 Reads

[Zwiększenie częstości zachorowania na ostre popaciorkowcowe kłębuszkowe zapalenie nerek w pierwszej połowie roku 2018 - doświadczenie jednego ośrodka].

Pol Merkur Lekarski 2019 Mar;46(273):115-121

Medical University of Warsaw: Department of Pediatrics and Nephrology.

Acute poststreptococcal glomerulonephritis (APSGN) is a complication of infection with group A beta-hemolytic streptococcus. The disease manifests as microscopic/gross hematuria, arterial hypertension, edema, and acute kidney injury and has most commonly self-limiting course.

Aim: The aim of study was the analysis of clinical course of APSGN in period of increased incidence in the first half of 2018. Read More

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March 2019
1 Read

The TNF-derived TIP peptide activates the epithelial sodium channel and ameliorates experimental nephrotoxic serum nephritis.

Kidney Int 2019 Mar 18. Epub 2019 Mar 18.

Department of Medicine, Augusta University, Augusta, Georgia, USA; Vascular Biology Center, Augusta University, Augusta, Georgia, USA; Department of Pharmacology and Toxicology, Augusta University, Augusta, Georgia, USA. Electronic address:

In mice, the initial stage of nephrotoxic serum-induced nephritis (NTN) mimics antibody-mediated human glomerulonephritis. Local immune deposits generate tumor necrosis factor (TNF), which activates pro-inflammatory pathways in glomerular endothelial cells (GECs) and podocytes. Because TNF receptors mediate antibacterial defense, existing anti-TNF therapies can promote infection; however, we have previously demonstrated that different functional domains of TNF may have opposing effects. Read More

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http://dx.doi.org/10.1016/j.kint.2018.12.022DOI Listing
March 2019
1 Read
8.563 Impact Factor

[H Factor Deficiency: A Case with an Atypical Presentation].

Acta Med Port 2019 Feb 28;32(2):158-161. Epub 2019 Feb 28.

Unidade de Imunodeficiências Primárias. Serviço de Pediatria. Hospital Dona Estefânia. Centro Hospitalar Lisboa Central. Lisboa. Chronic Diseases Research Center. NOVA Medical School. Lisboa. Portugal.

We report a case of an 18-month-old boy with H factor deficiency with atypical presentation: recurrent acute otitis media and several maternal family members with autoimmune disorders (vitiligo, thyroiditis and immune trombocytopenia). Blood tests revealed low C3 and AH50, as well as low properdin and H factor. I factor was normal. Read More

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https://www.actamedicaportuguesa.com/revista/index.php/amp/a
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http://dx.doi.org/10.20344/amp.10301DOI Listing
February 2019
5 Reads

Spectrum of acute kidney injury associated with cocaine use: report of three cases.

BMC Nephrol 2019 Mar 20;20(1):99. Epub 2019 Mar 20.

Medical Sciences Postgraduate Program, Department of Internal Medicine, School of Medicine, Estadual University of Ceará, Fortaleza, Brazil.

Background: The consequences of cocaine use are multisystemic, such as, for instance, renal failure, hepatotoxicity and pulmonary toxicity, with renal alterations being the focus of the present study. The use of substances that modify the base composition of cocaine (or adulterants) aiming to potentiate its effects also has an impact on these manifestations. The present study aims to report three cases with different diagnosis of acute kidney injury related to cocaine use. Read More

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http://dx.doi.org/10.1186/s12882-019-1279-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6427899PMC
March 2019
3 Reads

Anti-LRP2 Nephropathy With Abundant IgG4-Positive Plasma Cells: A Case Report.

Am J Kidney Dis 2019 Mar 12. Epub 2019 Mar 12.

Department of Pathology, Oregon Health & Science University, Portland, OR. Electronic address:

In older adults, the most common kidney biopsy diagnoses include pauci-immune crescentic glomerulonephritis, membranous nephropathy, and focal segmental glomerulosclerosis. Recently, investigators described a small series of older patients (aged 66-80 years) with acute kidney injury and a kidney biopsy demonstrating tubular basement membrane (TBM) immune deposits of polytypic immunoglobulin G (IgG) and C3, acute tubular injury, and tubulointerstitial inflammation. They identified a circulating antibody against kidney tubular low-density lipoprotein (LDL) receptor-related protein 2 (LRP2; also known as megalin) in patients' sera and colocalization of LRP2 with IgG in TBM deposits. Read More

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http://dx.doi.org/10.1053/j.ajkd.2018.12.039DOI Listing
March 2019
1 Read
5.900 Impact Factor

Plasmapheresis and corticosteroids in infective endocarditis-related crescentic glomerulonephritis.

BMJ Case Rep 2019 Mar 14;12(3). Epub 2019 Mar 14.

Division of Nephrology, University of Missouri School of Medicine, Columbia, Missouri, USA.

Infective endocarditis (IE)-related glomerulonephritis (GN) typically resolves with the treatment of IE. A 59-year-old woman with a baseline creatinine of 0.7 mg/dL presented with rash on her legs, night sweats and weight loss for 3 weeks. Read More

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http://dx.doi.org/10.1136/bcr-2018-227672DOI Listing
March 2019
4 Reads

Analysis of neutrophil to lymphocyte ratio, platelet to lymphocyte ratio and mean platelet volume to platelet count ratio in children with acute stage of immunoglobulin A vasculitis and assessment of their suitability for predicting the course of the disease.

Rheumatol Int 2019 Mar 13. Epub 2019 Mar 13.

Department of Paediatrics, School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia in Katowice, ul. 3-go Maja 13-15, 41-800, Zabrze, Poland.

Immunoglobulin A vasculitis (IgAV) is the most common systemic vasculitis in developmental age. The disease is most often characterized by a self-limiting course and good prognosis, but sometimes serious complications, like gastrointestinal bleeding or glomerulonephritis, may develop. The neutrophil to lymphocyte (NLR) and the platelet to lymphocyte (PLR) ratios are indicators related to clinical outcome in various inflammatory diseases. Read More

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http://dx.doi.org/10.1007/s00296-019-04274-zDOI Listing
March 2019
4 Reads

The pattern and outcomes of childhood renal diseases at University of Abuja Teaching Hospital, Abuja, Nigeria: A 4 year retrospective review.

Niger Postgrad Med J 2019 Jan-Mar;26(1):53-60

Nephrology Unit, Department of Paediatrics, University of Abuja Teaching Hospital, Gwagwalada, Abuja, Nigeria.

Introduction: Renal disorders contribute to childhood morbidity and mortality in developing countries. Therefore, the knowledge of the burden of childhood renal diseases is required for preventive and management purposes. This article determines the pattern and the outcomes of childhood renal diseases seen at the University of Abuja Teaching Hospital (UATH), Gwagwalada, Abuja, Nigeria. Read More

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http://dx.doi.org/10.4103/npmj.npmj_174_18DOI Listing
March 2019
1 Read

Pauci-immune proliferative glomerulonephritis and fungal endocarditis: More than a mere coincidence?

BMJ Case Rep 2019 Mar 6;12(3). Epub 2019 Mar 6.

Medicine/Nephrology, University of Florida, Gainesville, Florida, USA.

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http://dx.doi.org/10.1136/bcr-2018-229059DOI Listing
March 2019
1 Read

End-stage renal disease secondary to anti-glomerular basement membrane disease in a child with common variable immunodeficiency.

Clin Nephrol Case Stud 2019 1;7:1-6. Epub 2019 Feb 1.

Division of Pediatric Nephrology, Department of Pediatrics.

Background: Anti-glomerular basement membrane (GBM) disease is caused by autoantibodies against the α3-chain of type IV collagen in the GBM. Common variable immunodeficiency (CVID) is a primary immunodeficiency manifested by hypogammaglobulinemia, inability to make functional antibody, and recurrent infections. This report extends the phenotype of CVID-associated autoimmune diseases to include anti-GBM disease. Read More

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http://dx.doi.org/10.5414/CNCS109510DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374989PMC
February 2019
2 Reads

Spectrum of biopsy proven renal disease in northern India: a single centre study.

Nephrology (Carlton) 2019 Mar 4. Epub 2019 Mar 4.

Department of Nephrology, All India Institute of Medical Sciences, New Delhi, India-110029.

Aim: Pattern of kidney diseases varies across geographies due to multiple factors. There is a paucity of information from South Asia due to absence of nationwide/regional biopsy registries. This study aimed to delineate the spectrum of renal parenchymal diseases in our region. Read More

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http://doi.wiley.com/10.1111/nep.13582
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http://dx.doi.org/10.1111/nep.13582DOI Listing
March 2019
14 Reads

Successful use of rituximab for hydralazine-induced anti-neutrophil cytoplasmic antibodies-associated vasculitis.

Saudi J Kidney Dis Transpl 2019 Jan-Feb;30(1):226-230

Department of Medicine, Division of Nephrology, Washington University School of Medicine, St. Louis, MO, USA.

Hydralazine is a commonly used anti-hypertensive medication. It can, however, contribute to the development of autoimmunity, in the form of drug-induced lupus and anti-neutrophil cytoplasmic antibodies-associated vasculitis. We report a 45-year-old patient with hypertension managed with hydralazine for four years who presented with rapidly progressive glomerulonephritis (RPGN), requiring hemodialysis, and diffuse alveolar hemorrhage (DAH), requiring mechanical ventilation, and extracorporeal membrane oxygenation. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6435256PMC
February 2019

IgA nephropathy: Missed diagnosis and renal transplant.

Saudi J Kidney Dis Transpl 2019 Jan-Feb;30(1):221-225

Department of Biochemistry, Faculty of Medicine, Umm Al-Qurra University, Mecca, Saudi Arabia.

The most common form of chronic glomerulonephritis worldwide is IgA nephropathy (IgAN) where IgA immune complexes are deposited in the glomeruli. About 40%-45% of patients with IgAN present with macroscopic hematuria. Diagnosis occurs through kidney biopsy to visualize IgA deposition in the glomerular mesangial area using immunofluorescence microscopy. Read More

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February 2019
11 Reads

[Acute renal failure of glomerular origin].

Authors:
Éric Thervet

Rev Prat 2018 Feb;68(2):160-165

Service de néphrologie, département hypertension artérielle, prévention et prise en charge des affections rénales et cardiovasculaires, Hôpital européen Georges-Pompidou, Assistance publique-Hôpitaux de Paris, université Paris-Descartes Paris, France.

Acute renal failure of glomerular origin. Glomerulopathies account for about 10% of acute kidney injury (AKI) in adults. They often require urgent care. Read More

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February 2018
1 Read

First Report of a Disease by Rhazes 10 Centuries Ago.

Int J Prev Med 2019 15;10. Epub 2019 Jan 15.

Department of Anesthesiology and Intensive Care Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.

Introduction: Abu Bakr Mohammad Ibn Zakariya Al-Razi (865-925 CE), who was known as "Rhazes" in the west, was a famous scientist of medieval ages. He has more than 200 books and treatises. His masterpiece on medicine "" contains around 900 case reports. Read More

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http://dx.doi.org/10.4103/ijpvm.IJPVM_216_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360843PMC
January 2019
2 Reads

An atypical pneumonia.

Respirol Case Rep 2019 Apr 5;7(3):e00407. Epub 2019 Feb 5.

Department of Thoracic Medicine The Prince Charles Hospital Brisbane Australia.

We describe a patient with underlying HIV presenting with progressive respiratory distress and acute renal failure. A unifying diagnosis of microscopic polyangiitis was made. Following immunosuppression induction with plasma exchange and intravenous corticosteroid and subsequent maintenance immunosuppression with intravenous cyclophosphamide in conjunction with renal replacement therapy he achieved remission. Read More

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http://dx.doi.org/10.1002/rcr2.407DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363593PMC
April 2019
3 Reads

A Controlled Human Infection Model of Group A Pharyngitis: Which Strain and Why?

mSphere 2019 02 13;4(1). Epub 2019 Feb 13.

Tropical Diseases, Murdoch Children's Research Institute, Melbourne, Victoria, Australia

Group A (GAS) is a major cause of global infection-related morbidity and mortality. A modern controlled human infection model (CHIM) of GAS pharyngitis can accelerate vaccine development and pathogenesis research. A robust rationale for strain selection is central to meeting ethical, scientific, and regulatory requirements. Read More

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http://dx.doi.org/10.1128/mSphere.00647-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374595PMC
February 2019
2 Reads

Association of hemophagocytic lymphohistiocytosis with kidney lesions in acute African swine fever virus infection

Ann Parasitol 2018;64(4):343-350

Department of Medical Biology and Parasitology, Armenia Yerevan State Medical University, 2 Koryun St., Yerevan 0025, Armenia

Glomerulonephritis due to African swine fever (ASF) is well documented. However, there is absence of good understanding of mechanisms involved in the development of pathology development. This study examines glomerulonephritis in association with acute infection induced by II genotype (Georgia 2007) of ASF virus. Read More

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April 2019
3 Reads

Distinction between MPO-ANCA and PR3-ANCA-associated glomerulonephritis in Chinese patients: a retrospective single-center study.

Clin Rheumatol 2019 Feb 8. Epub 2019 Feb 8.

Jinling Clinical Medical College of Nanjing Medical University, Nanjing, China.

Objectives: To retrospectively investigate the clinical and histological features and outcomes of ANCA-associated glomerulonephritis (AAGN) with different ANCA serotypes.

Method: A total of 467 AAGN patients were divided into MPO-AAGN (MPO) and PR3-AAGN (PR3) groups according to ANCA serotype. Clinical and histological features and renal outcomes were compared. Read More

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http://dx.doi.org/10.1007/s10067-019-04458-9DOI Listing
February 2019
7 Reads
1.774 Impact Factor

Relationship of Remodeling of Carotid Arteries and Left Ventricular Geometry in Patients With Chronic Glomerulonephritis.

Kardiologiia 2018 Nov 18;58(4):45-52. Epub 2018 Nov 18.

Кыргызская государственная медицинская академия им. И. К. Ахунбаева; Кыргызско-Российский Славянский университет им. первого Президента России Б. Н. Ельцина.

Purpose: to study clinical-functional features of remodeling of carotid arteries and its relation to restructuring of the left ventricle (LV) in patients with chronic glomerulonephritis at pre-dialysis stage.

Materials And Methods: We examined 269 patients (189 men, 80 women) with chronic glomerulonephritis (CGN) aged 17-71 years, at pre-dialysis stages of the disease. We analyzed biochemical parameters of peripheral blood with the determination of daily proteinuria and glomerular filtration rate (GFR). Read More

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http://dx.doi.org/10.18087/cardio.2018.4.10108DOI Listing
November 2018
3 Reads

Relationship between serologic profile (ANCA type) and clinical features of renal involvement in ANCA-associated vasculitides.

Ter Arkh 2018 Jun;90(6):15-21

I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenov University), Moscow, Russia.

Aim: To compare the frequency, clinical features and outcomes of renal involvement in ANCA-associated vasculitides (AAV) in patients with antibodies against proteinase-3 (pr3-ANCA) and myeloperoxidase (MPO-ANCA).

Materials And Methods: In our retrospective study we enrolled 264 patients, 94 males and 170 females, median age 53 [36; 62] years. Among them 157 were pr3-ANCA positive and 107 were MPO-ANCA positive. Read More

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http://dx.doi.org/10.26442/terarkh201890615-21DOI Listing
June 2018
2 Reads

Leukocytoclastic vasculitis with late-onset Henoch-Schönlein purpura after trifluridine/tipiracil treatment.

Dermatol Online J 2018 Oct 15;24(10). Epub 2018 Oct 15.

Department of Dermatology, The University of Texas McGovern Medical School, Houston, Texas.

Trifluridine/tipiracil has been approved for the treatment of refractory metastatic colorectal cancer. Adverse effects of this drug combination include leukopenia, neutropenia, fatigue, diarrhea, and vomiting. We present a case of trifluridine/tipiracil-induced leukocytoclastic vasculitis (LCV) with late-onset Henoch-Schönlein purpura (HSP) in a 42-year-old man with metastatic appendiceal cancer. Read More

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October 2018
4 Reads

Infliximab-associated focal segmental glomerulosclerosis in a patient with ankylosing spondylitis.

Rheumatol Int 2019 Mar 23;39(3):561-567. Epub 2019 Jan 23.

Division of Rheumatology, Department of Internal Medicine, Dokuz Eylul University School of Medicine, Izmir, Turkey.

The introduction of tumor necrosis factor-alpha (TNF-α)-targeting drugs has given new opportunities in the treatment of various inflammatory rheumatic diseases and has been the most important development in the treatment of spondyloarthritis (SpA). However, the increasing use and longer follow-up periods of treatment also pose risks of developing various adverse effects ranging from common ones including infections to uncommon renal complications. This report describes a case of infliximab-induced focal segmental glomerulosclerosis (FSGS) in a 40-year-old female patient with ankylosing spondylitis (AS) who presented with asymptomatic proteinuria and microscopic hematuria. Read More

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http://link.springer.com/10.1007/s00296-019-04241-8
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http://dx.doi.org/10.1007/s00296-019-04241-8DOI Listing
March 2019
14 Reads

Acute IgA-Dominant Glomerulonephritis Associated with Syphilis Infection in a Pregnant Teenager: A New Disease Association.

J Clin Med 2019 Jan 18;8(1). Epub 2019 Jan 18.

Department of Pathology, National Institute of Cardiology "Ignacio Chávez", Mexico City 14000, Mexico.

Chronic kidney disease (CKD) is increasingly recognized as a risk factor in pregnancy; the differential diagnosis between CKD and preeclampsia (PE) may be of pivotal importance for pregnancy management and for early treatment of CKD. Acknowledging this connection may be useful also in a wider context, such as in the case reported in this paper, which for the first time describes an association between syphilis infection and IgA-dominant glomerulonephritis. A 16-year-old woman, referred to a general hospital due to a seizure, was found to be unknowingly pregnant. Read More

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http://www.mdpi.com/2077-0383/8/1/114
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http://dx.doi.org/10.3390/jcm8010114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6352144PMC
January 2019
21 Reads

[Relapse of acute rheumatism fever associated with acute post-streptococcal glomerulonephritis].

Presse Med 2019 Feb 18;48(2):193-195. Epub 2019 Jan 18.

Centre hospitalier de Polynésie française, service de médecine interne et polyvalente, Tahiti, Polynésie française. Electronic address:

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http://dx.doi.org/10.1016/j.lpm.2018.11.024DOI Listing
February 2019
2 Reads

The renal draining lymph nodes in acute inflammatory kidney disease.

Kidney Int 2019 Feb;95(2):254-256

Centre for Inflammatory Diseases, Monash University Department of Medicine, Monash Medical Centre, Clayton, Victoria, Australia; Department of Nephrology, Monash Health, Clayton, Victoria, Australia; Department of Clinical Immunology, Monash Health, Clayton, Victoria, Australia.

Renal lymphatics are implicated in renal disease, but their function in inflammatory kidney diseases is relatively poorly defined. In the current issue, Kasinath et al. examine the role of the kidney draining lymph node in experimental glomerulonephritis, as well the role of fibroblastic reticular cells within lymph nodes. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00852538183079
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http://dx.doi.org/10.1016/j.kint.2018.10.011DOI Listing
February 2019
12 Reads

Dabigatran causing severe acute kidney injury in a patient with liver cirrhosis.

CEN Case Rep 2019 May 18;8(2):125-127. Epub 2019 Jan 18.

Renal Unit, Department of Medicine, Queen Elizabeth Hospital, 30 Gascoigne Road, Kowloon, Hong Kong, SAR, China.

Anticoagulant-related nephropathy (ARN), a significant but frequently undiagnosed problem in patients receiving anticoagulation, is found to be associated with increased renal morbidity and all-cause mortality. While ARN is mainly associated with warfarin use, recent case reports suggest that it may also occur in patients taking direct oral anticoagulants (DOAC). We report a patient who had a history of alcoholic liver cirrhosis and paroxysmal atrial fibrillation, and received dabigatran 110 mg twice daily for 1 year. Read More

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http://dx.doi.org/10.1007/s13730-019-00378-4DOI Listing
May 2019
10 Reads

Pneumonia-Associated Acute Glomerulonephritis: Report of 2 Cases.

Clin Pediatr (Phila) 2019 May 18;58(5):582-585. Epub 2019 Jan 18.

1 Pediatric Nephrology Unit, Hospital Pediátrico, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal.

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http://dx.doi.org/10.1177/0009922818825157DOI Listing
May 2019
3 Reads

Reactivation of resolved hepatitis B virus infection combined with nephrotic syndrome in a patient after allogeneic haematopoietic stem cell transplantation.

BMC Infect Dis 2019 Jan 16;19(1):57. Epub 2019 Jan 16.

Department of Hematology, The Third Affiliated Hospital, Sun Yat-sen University, 600 Tianhe Road, Guangzhou, China.

Background: After allogeneic haematopoietic stem cell transplantation (allo-HSCT), Hepatitis B virus reactivation (HBVr) can be observed in patients with previous resolved Hepatitis B virus (HBV) infections. Nephrotic syndrome (NS) is the main clinical manifestation of HBsAg-positive glomerulonephritis. However, the development of HBVr combined with NS after allo-HSCT is uncommon. Read More

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http://dx.doi.org/10.1186/s12879-019-3690-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6335709PMC
January 2019
5 Reads

Role of regulatory T cells in experimental autoimmune glomerulonephritis.

Am J Physiol Renal Physiol 2019 Mar 16;316(3):F572-F581. Epub 2019 Jan 16.

Institute of Immunology, University Medical Center Hamburg-Eppendorf , Hamburg , Germany.

Anti-glomerular basement membrane (anti-GBM) disease is characterized by antibodies and T cells directed against the Goodpasture antigen, the noncollagenous domain of the α3-chain of type IV collagen [α3(IV)NC1] of the GBM. Consequences are the deposition of autoantibodies along the GBM and the development of crescentic glomerulonephritis (GN) with rapid loss of renal function. Forkhead box protein P3 (Foxp3) regulatory T (Treg) cells are crucial for the maintenance of peripheral tolerance to self-antigens and the prevention of immunopathology. Read More

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http://dx.doi.org/10.1152/ajprenal.00558.2018DOI Listing
March 2019
4 Reads

Therapy Side Effects in Systemic Lupus Erythematosus.

Curr Health Sci J 2018 Jul-Sep;44(3):316-321. Epub 2018 Jul 15.

Department of Pharmacology, University of Medicine and Pharmacy of Craiova, Romania.

Glucosteroids (GS) are widely used drugs for various inflammatory pathologies (Nephrotic syndrome, Proliferative glomerulonephritis, Extramembrane glomerulonephritis, Nephropathy of the Nodous Poliarterita (PAN), Nephropathy from purple Henoch-Schonlein, lupus nephropathy (LN), Acute adrenal insufficiency Waterhouse-Friederichsen, Chronic adrenal insufficiency Addison, Systemic Lupus Erythematosus (SLE), Polymyositis and dermatomyositis, Chronic granulomatosis, Crohn's disease, Hemorrhagic rectocolitis, Hemolytic anemias, Acute leukemias and chronic lymphocytic leukemia, Hodgkin's lymphoma). Although they are prescribed for their anti-inflammatory and immunosuppressive properties, they also have many side effects, hyperglycemia being one of the most common and representative, which is why these drugs need careful monitoring when administered over the long term. This paper presents the case of a 39 year old patient diagnosed with systemic lupus erythematosus (SLE) with class IV lupus nephropathy (LN) who developed numerous complications due to the pathogenic side effects: diabetes, amenorrhea, recurrent infections, and depression. Read More

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http://dx.doi.org/10.12865/CHSJ.44.03.18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311221PMC
July 2018
13 Reads

Clinical outcomes in patients with biopsy-proved diabetic nephropathy compared to isolated lupus or crescentic glomerulonephritis.

Diabetes Res Clin Pract 2019 Feb 11;148:144-151. Epub 2019 Jan 11.

Renal Division, Department of Internal Medicine, National Taiwan University Hospital, College of Medicine, National Taiwan University, No. 7, Chung Shan S. Rd., Zhongzheng Dist., Taipei City 10002, Taiwan. Electronic address:

Aims: Diabetic nephropathy (DMN) is usually diagnosed clinically without pathology, and the prognosis of which compared to non-diabetic renal diseases has rarely been investigated especially in ethnic Chinese population. Here we reported the outcome of patients with biopsy-proved DMN compared to those with isolated crescentic glomerulonephritis (GN) or lupus nephritis (LN).

Methods: This retrospective observational study included patients with DMN (n = 55), crescentic GN (n = 48) and LN (n = 82) from an original cohort of 987 adult patients who underwent kidney biopsy. Read More

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http://dx.doi.org/10.1016/j.diabres.2019.01.014DOI Listing
February 2019
5 Reads

[Diagnosis and treatment of kidney involvement in plasma cell diseases : Renal involvement in multiple myeloma and monoclonal gammopathies].

Internist (Berl) 2019 Jan;60(1):10-22

Klinik für Nieren- und Hochdruckerkrankungen, Medizinische Hochschule Hannover, Carl-Neuberg-Str. 1, 30625, Hannover, Deutschland.

Background: Kidney involvement is a common complication in patients with plasma cell diseases.

Objective: This article outlines the spectrum of renal involvement in plasma cell dyscrasia and describes diagnostic and therapeutic measures to guide clinical management.

Material And Methods: Evaluation and discussion of the current literature as well as existing guidelines and recommendations of professional societies. Read More

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http://dx.doi.org/10.1007/s00108-018-0538-7DOI Listing
January 2019
3 Reads

Dietary Chrysin Suppresses Formation of Actin Cytoskeleton and Focal Adhesion in AGE-Exposed Mesangial Cells and Diabetic Kidney: Role of Autophagy.

Nutrients 2019 Jan 9;11(1). Epub 2019 Jan 9.

Department of Food and Nutrition, Hallym University, Chuncheon, Kangwon-do 24252, Korea.

Advanced glycation end products (AGE) play a causative role in the development of aberrant phenotypes of intraglomerular mesangial cells, contributing to acute/chronic glomerulonephritis. The aim of this study was to explore mechanistic effects of the flavonoid chrysin present in bee propolis and herbs on actin dynamics, focal adhesion, and the migration of AGE-exposed mesangial cells. The in vitro study cultured human mesangial cells exposed to 33 mM glucose and 100 μg/mL AGE-bovine serum albumin (AGE-BSA) for up to 5 days in the absence and presence of 1⁻20 μM chrysin. Read More

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http://www.mdpi.com/2072-6643/11/1/127
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http://dx.doi.org/10.3390/nu11010127DOI Listing
January 2019
14 Reads

Anticoagulant Related Nephropathy Induced by Dabigatran.

Case Rep Nephrol 2018 9;2018:7381505. Epub 2018 Dec 9.

Department of Medicine, University of Calgary, Canada.

We describe a case of biopsy-proven dabigatran related nephropathy in a patient without underlying IgA nephropathy. To date, dabigatran related nephropathy was only reported in patients with concurrent or undiagnosed IgA nephropathy, suggesting that it may predispose patients to dabigatran associated injury. The patient is an 81-year-old woman with multiple medical comorbidities, including nonvalvular atrial fibrillation, who was anticoagulated with dabigatran. Read More

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http://dx.doi.org/10.1155/2018/7381505DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304482PMC
December 2018
6 Reads