8,548 results match your criteria Glomerulonephritis Acute

Clinical and pathological characteristics of patients with acute kidney injury in Japan in whom kidney biopsy was performed: a cross-sectional analysis of the Japan Renal Biopsy Registry (J‑RBR).

Clin Exp Nephrol 2022 May 20. Epub 2022 May 20.

Department of Pathology, Keio University School of Medicine, Tokyo, Japan.

Introduction: Acute kidney injury (AKI) is a worldwide concern and it leads to a poor prognosis or end-stage kidney disease. The purpose of this study was to clarify the characteristics of patients with AKI in whom kidney biopsy was performed using data of the Japan Renal Biopsy Registry (J-RBR).

Methods: We screened 38,351 cases that were registered in the J-RBR from 2007 to 2018. Read More

View Article and Full-Text PDF

[IgA vasculitis - similarities and differences to IgA nephropathy].

Ther Umsch 2022 Jun;79(5):260-268

Klinik Rheumatologie & Schmerzmedizin, Bethesda Spital Basel.

IgA vasculitis - similarities and differences to IgA nephropathy IgA vasculitis (IgAV), formerly called Henoch-Schönlein Purpura (HSP) is an immune complex-mediated vasculitis of small vessels typically affecting the skin, gastrointestinal tract, and the kidneys. Based on distinct histopathological and pathophysiological commonalities of IgAV and IgA nephropathy (IgAN) they are viewed as part of a spectrum of IgA-mediated inflammatory syndromes. While the disease course in children is most often benign, IgAV has a high risk of renal and gastrointestinal complications when first appearing in adulthood. Read More

View Article and Full-Text PDF

Kidney Disease in Ankylosing Spondylitis: a case series and review of the literature.

J Bras Nefrol 2022 May 13. Epub 2022 May 13.

Centro Hospitalar de Lisboa Central, Hospital Curry Cabral, Departamento de Nefrologia, Lisboa, Portugal.

Background: Kidney disease is a rare manifestation of ankylosing spondylitis (AS) and its pathological alterations remain poorly described. The aim of this study was to investigate the clinical presentation and pathological alterations on kidney biopsy of AS patients and review and discuss the current literature on the issue.

Methods: We retrospectively studied the clinical presentation and kidney pathological alterations of 15 Caucasian AS patients submitted to kidney biopsy between October 1985 and March 2021. Read More

View Article and Full-Text PDF

Microscopic Polyangiitis Following mRNA COVID-19 Vaccination: A Case Report.

J Korean Med Sci 2022 May 16;37(19):e154. Epub 2022 May 16.

Department of Internal Medicine, Hanyang University Guri Hospital, Guri, Korea.

Coronavirus disease 2019 (COVID-19) is one of the most widespread viral infections in human history. As a breakthrough against infection, vaccines have been developed to achieve herd immunity. Here, we report the first case of microscopic polyangiitis (MPA) following BNT162b2 vaccination in Korea. Read More

View Article and Full-Text PDF

ANCA-Negative Vasculitis in Eosinophilic Granulomatosis with Polyangiitis Complicated with Membranous Nephropathy: A Case Report and Brief Literature Review.

Case Rep Nephrol 2022 6;2022:8110940. Epub 2022 May 6.

Department of Nephrology, Tokyo Women's Medical University, 8-1 Kawada-cho, Shinjyuku-ku, Tokyo 162-0054, Japan.

Renal involvement in eosinophilic granulomatosis with polyangiitis (EGPA) typically occurs in anti-neutrophil cytoplasmic autoantibody (ANCA)-positive cases presenting with rapidly progressive renal insufficiency and urinary abnormalities induced by primarily necrotizing crescentic glomerulonephritis (NCGN). Recently, ANCA-negative EGPA has also been reported to manifest with renal involvement, such as NCGN or non-NCGN, including membranous nephropathy (MN). Herein, we report a 70-year-old female who presented with purpura on the lower legs, upper limb numbness, renal dysfunction (eGFR, 20. Read More

View Article and Full-Text PDF

Value of Neutrophil-Lymphocyte and Platelet-Lymphocyte Ratios in the Evaluation of Acute Rejection and Chronic Allograft Nephropathy in Children With Kidney Transplantation.

Exp Clin Transplant 2022 May;20(Suppl 3):129-136

From the Department of Pediatrics, Gazi University, Ankara, Turkey.

Objectives: Neutrophil-to-lymphocyte ratio and platelet (thrombocyte)-to-lymphocyte ratio have become accepted markers of inflammation in recent years and are used to assess disease activity in some diseases. In this study, we investigated the relationship between these values and acute rejection attacks, as well as their role in determining chronic allograft nephropathy, in follow-up of pediatric kidney transplant recipients.

Materials And Methods: Our study included 58 kidney transplant recipients (age 5-18 years) with at least 5-year follow-up at our center. Read More

View Article and Full-Text PDF

Exposure of female NZBWF1 mice to imiquimod-induced lupus nephritis at an early age via a unique mechanism that differed from spontaneous onset.

Clin Exp Immunol 2022 May;208(1):33-46

Institute for Environment and Gender-Specific Medicine, Juntendo University Graduate School of Medicine, Chiba 279-0021, Japan.

Systemic lupus erythematosus (SLE) is a chronic inflammatory and representative autoimmune disease. Extremely complicated and multifactorial interactions between various genetic factors and individual susceptibility to environmental factors are involved in the pathogenesis of SLE. Several studies have reported that mutation and activation of toll-like receptor (TLR) 7 are involved in the onset of autoimmunity, including SLE. Read More

View Article and Full-Text PDF

Bartonella endocarditis and diffuse crescentic proliferative glomerulonephritis with a full-house pattern of immune complex deposition.

BMC Nephrol 2022 May 12;23(1):181. Epub 2022 May 12.

Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN, USA.

Background: Bartonella endocarditis is often a diagnostic challenge due to its variable clinical manifestations, especially when it is first presented with involvement of organs other than skin and lymph nodes, such as the kidney.

Case Presentation: This was a 13-year-old girl presenting with fever, chest and abdominal pain, acute kidney injury, nephrotic-range proteinuria and low complement levels. Her kidney biopsy showed diffuse crescentic proliferative glomerulonephritis with a full-house pattern of immune complex deposition shown by immunofluorescence, which was initially considered consistent with systemic lupus erythematous-associated glomerulonephritis (lupus nephritis). Read More

View Article and Full-Text PDF

Q-uestioning the Diagnosis: An Educational Case Report.

Can J Kidney Health Dis 2022 2;9:20543581221097749. Epub 2022 May 2.

Division of Nephrology, Department of Medicine, Dalhousie University, Halifax, NS, Canada.

Rationale: Q fever is a zoonotic infection that may lead to acute or long-term renal injury. Given its rare incidence, Q fever is not often considered on the initial differential diagnosis for glomerular disease which can lead to delays in treatment. This case highlights the importance of avoiding early diagnostic closure and revisiting the differential diagnosis in the setting of an atypical clinical presentation or response to treatment. Read More

View Article and Full-Text PDF

[Role of systemic infections in canine kidney diseases].

Tierarztl Prax Ausg K Kleintiere Heimtiere 2022 Apr 6;50(2):124-136. Epub 2022 May 6.

Medizinische Kleintierklinik, Zentrum für klinische Tiermedizin, Ludwig-Maximilians-Universität München.

Kidney diseases represent a common problem as well as a frequent cause of death in dogs. Infectious agents may be responsible for glomerulopathies and acute kidney injuries. Many infections commonly associated with the development of immune complex glomerulonephritis in central and southern Europe are important as travel-associated diseases in Germany. Read More

View Article and Full-Text PDF

Clinical spectrum of gross haematuria following SARS-CoV-2 vaccination with mRNA vaccines.

Clin Kidney J 2022 May 21;15(5):961-973. Epub 2021 Dec 21.

Division of Nephrology, University Hospital Zurich, Zurich, Switzerland.

Background: Novel messenger RNA (mRNA)-based vaccines play an important role in current vaccination campaigns against SARS-CoV-2. They are highly efficacious and generally well tolerated. Vaccination in patients with immune-mediated kidney diseases is recommended. Read More

View Article and Full-Text PDF

Successful Treatment of COVID-19-Related Immune- Complex Glomerulonephritis, Case Report.

Iran J Kidney Dis 2022 Mar;16(2):147-151

University of Health Sciences, Gazi Yasargil Training and Research Hospital, Nephrology Department , Diyarbakir, Turkey.

Acute kidney injury (AKI) , proteinuria in the nephrotic or subnephrotic range and hematuria might be seen in patients with coronavirus disease 2019 (COVID-19) infection. In this case study we present a 59 years old manwho was diagnosed with immune-complex glomerulonephritis after development of rapidly progressive kidney failure accompanied by pulmonary hemorrhage, 2 months after COVID-19 infection. The patient was hospitalised with the diagnosis of acute kidney injury and nephrotic syndrome. Read More

View Article and Full-Text PDF

The difference between patients with nephrotic syndrome and nephrotic-range proteinuria in IgA nephropathy: a propensity score matched cohort study.

BMC Nephrol 2022 04 29;23(1):163. Epub 2022 Apr 29.

Department of Nephrology, Tianjin Medical University General Hospital, No. 154, Anshan Road, Heping District, Tianjin, China.

Objective: To date, nephrotic syndrome (NS) has not been well characterized in patients with IgA nephropathy (IgAN). Whether decline in serum albumin is an ominous sign in IgAN patients with massive proteinuria remains unknown. In this study, we evaluated clinical and pathological features of IgAN with NS and compared the differences for these features and long-term outcomes between patients with nephrotic syndrome and nephrotic-range proteinuria. Read More

View Article and Full-Text PDF

Paediatric Dialysis at a Tertiary Hospital in South-West Nigeria: A 4-Year Report.

Blood Purif 2022 Apr 28:1-7. Epub 2022 Apr 28.

Division of Pediatric Nephrology, Department of Pediatrics, Alberta Children's Hospital, University of Calgary, Calgary, Alberta, Canada.

Introduction: Dialysis is potentially lifesaving in children with acute kidney injury (AKI) or chronic kidney disease (CKD), but availability is limited in low-income countries and lower-middle-income countries (LMICs).

Methods: In the present study, we perform a 4-year study of patients who received peritoneal dialysis (PD) or haemodialysis (HD) at the Paediatric Nephrology Unit of the University College Hospital Ibadan, Nigeria. Subgroup analysis was performed on patients with sepsis or malaria AKI who underwent HD or PD for predictors of in-hospital mortality. Read More

View Article and Full-Text PDF

Virus-related collapsing glomerulopathy, a common mechanism of injury?

Joseph P Gaut

Kidney Int 2022 05;101(5):880-882

Department of Pathology and Immunology, Washington University School of Medicine in St. Louis, St. Louis, Missouri, USA; Department of Internal Medicine, Washington University School of Medicine in St. Louis, St. Louis, Missouri, USA. Electronic address:

Collapsing glomerulopathy frequently shows focal lesions on biopsy, creating challenges with transcriptomic investigations because of inadequate tissue sample. This challenge is overcome with spatial transcriptomics, technology linking transcriptomic data to histology. Applying this technology to investigate patients with collapsing glomerulopathy related to HIV infection or severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Smith et al. Read More

View Article and Full-Text PDF

Acute glomerulonephritis.

Lancet 2022 04;399(10335):1646-1663

Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN, USA. Electronic address:

Glomerulonephritis is a heterogeneous group of disorders that present with a combination of haematuria, proteinuria, hypertension, and reduction in kidney function to a variable degree. Acute presentation with full blown nephritic syndrome or rapidly progressive glomerulonephritis is uncommon and is mainly restricted to patients with post-infectious glomerulonephritis, anti-neutrophil cytoplasmic antibodies-associated vasculitis, and anti-glomerular basement membrane disease. Most frequently, patients present with asymptomatic haematuria and proteinuria with or without reduced kidney function. Read More

View Article and Full-Text PDF

Clinical Predictors and Prognosis of Recurrent IgA Nephropathy in the Kidney Allograft.

Glomerular Dis 2022 Jan 24;2(1):42-53. Epub 2021 Sep 24.

Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, USA.

Introduction: Although IgA nephropathy (IgAN) is the most common recurrent glomerulonephritis encountered in the kidney allograft, the clinical and immunogenetic characteristics remain poorly understood. We sought to study determinants and prognosis of recurrent IgAN with special focus on HLA antigens.

Materials And Methods: Between 2005 and 2019, we identified 282 transplanted patients with failure secondary to IgAN from two North American and one European Medical Centers, including 80 with recurrent IgAN and 202 without recurrence. Read More

View Article and Full-Text PDF
January 2022

Protocol-based donor-derived cell-free DNA surveillance in kidney transplant recipients: A single-center experience.

Clin Nephrol 2022 Apr 21. Epub 2022 Apr 21.

Aims: Donor-derived cell-free DNA (dd-cfDNA) surveillance testing has never been studied in comparison with other surveillance tests. In this study we aim to describe our center's clinical experience with routine dd-cfDNA monitoring and to assess whether monitoring dd-cfDNA by protocol provides additional information that aids in detection of acute rejection.

Materials And Methods: We implemented the dd-cfDNA (Allosure) surveillance protocol in addition to measurements of serum creatinine, proteinuria, and donor-Specific antibody. Read More

View Article and Full-Text PDF

Acute Renal Failure and Nephrotic Syndrome Secondary to Collapsing Glomerulopathy Associated With Hepatitis C.

Cureus 2022 Mar 15;14(3):e23175. Epub 2022 Mar 15.

Gastroenterology and Hepatology, Ascension Health, Grand Blanc, USA.

Collapsing glomerulopathy (CG) is a rare variant of focal segmental glomerulosclerosis (FSGS) that commonly presents as nephrotic syndrome in patients. CG is almost always associated with human immunodeficiency virus (HIV) infection but is rarely from other infectious sources such as parvovirus, Epstein-Barr virus, cytomegalovirus, and SARS-CoV-2. CG has also been reported to be related to other etiologies such as genetic disorders, lupus, malignancy, and post-renal transplant but is exceedingly rare when related to hepatitis C virus (HCV). Read More

View Article and Full-Text PDF

Deceased Donor Renal Transplantation: 6 Year Experience from a Tertiary Care Center in North India.

J Assoc Physicians India 2022 Apr;70(4):11-12

Sms Medical College and Hospital, New Delhi.

The incident of End stage renal disease (ESRD) is rising rapidly worldwide. Renal transplant is the best modality of treatment, offering a better quality of life and mortality benefit, as compared with long-term dialysis. Very few patients have a live renal transplant donor, for rest, a decreased donor renal transplant is the only alternative. Read More

View Article and Full-Text PDF

Diverse and atypical manifestations of Q fever in a metropolitan city hospital: Emerging role of next-generation sequencing for laboratory diagnosis of Coxiella burnetii.

PLoS Negl Trop Dis 2022 04 20;16(4):e0010364. Epub 2022 Apr 20.

Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China.

Although Q fever has been widely reported in the rural areas of China, there is a paucity of data on the epidemiology and clinical characteristics of this disease in large metropolitan cities. In this study, we profile the epidemiology and clinical manifestations of Q fever from a tertiary hospital in Shenzhen, a Southern Chinese metropolitan city with a large immigrant population from other parts of China. A total of 14 patients were confirmed to have Q fever during a nine-year-and-six-month period, five of whom were retrospectively diagnosed during case review or incidentally picked up because of another research project on unexplained fever without localizing features. Read More

View Article and Full-Text PDF

Epidermal growth factor deficiency predisposes to progressive renal disease.

FASEB J 2022 05;36(5):e22286

Department of Dermatology, Cutaneous Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, USA.

Epidermal growth factor (EGF) is produced in the kidney by thick ascending limbs of the loop of Henle and by distal convoluted tubules (DCTs). Reduced urinary EGF levels have been associated with chronic kidney disease but it is not known whether physiological levels of EGF protect the kidney from progressive renal disease. Here, we show that EGF-deficient mice on a mixed genetic background had increased urinary microalbumin, and a subset of these mice developed severe progressive renal disease with azotemia that was not seen in WT or TGFα-deficient littermates with this mixed genetic background. Read More

View Article and Full-Text PDF

A case report of spontaneous ovarian hyperstimulation syndrome and the long-term management of the endocrine disorder.

Ann Transl Med 2022 Mar;10(6):384

Department of Reproduction and Infertility, Chengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.

Background: Spontaneous ovarian hyperstimulation syndrome (sOHSS) is a rarely reported clinical symptom of uncertain origin with the incidence of 0.2-1.2%. Read More

View Article and Full-Text PDF

Antineutrophil Cytoplasmic Autoantibody-Associated Glomerulonephritis as a Complication of Home Parenteral Nutrition.

Case Rep Nephrol Dial 2022 Jan-Apr;12(1):22-30. Epub 2022 Mar 14.

Department of Nephrology, General University Hospital, Prague, Czechia.

Patients on long-term home parenteral nutrition (HPN) occasionally develop glomerulonephritis due to chronic central venous catheter (CVC)-related infection. Most previously reported cases were membranoproliferative glomerulonephritis (MPGN). This is a case report of a 16-year-old girl receiving HPN for short bowel syndrome. Read More

View Article and Full-Text PDF

Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis Complicated by Thrombotic Microangiopathy with Posterior Reversible Encephalopathy Syndrome Successfully Treated with Eculizumab: A Case Report.

Mod Rheumatol Case Rep 2022 Apr 15. Epub 2022 Apr 15.

Department of Nephrology and Rheumatology, Aichi Medical University, Nagakute, Aichi, Japan.

Thrombotic microangiopathy is characterised by endothelial cell injury, intravascular platelet-fibrin thrombi, and vascular damage, leading to acute kidney injury, thrombocytopenia, and microangiopathic haemolytic anaemia. Among the autoimmune diseases related to thrombotic microangiopathy, anti-neutrophil cytoplasmic antibody-associated vasculitis-related thrombotic microangiopathy cases have been rarely reported; therefore, the optimal treatment for associated vasculitis-related thrombotic microangiopathy remains unknown. An 84-year-old woman without significant medical history presented with a 1-month history of general fatigue, fever, and deteriorating bilateral leg numbness and was admitted to our hospital. Read More

View Article and Full-Text PDF

A Case Report of Recurrent Glomerulonephritis 27 Years After Renal Transplant.

Cureus 2022 Mar 10;14(3):e23041. Epub 2022 Mar 10.

Hematology and Oncology, St. Joseph's Regional Medical Center, Paterson, USA.

Herein we present the case of a patient who was diagnosed with membranoproliferative glomerulonephritis and underwent renal transplant 27 years prior to presentation with new kidney failure. Although our patient did not undergo renal biopsy, it is our thought that she developed recurrent membranoproliferative disease, as she was well maintained on immunosuppressants and steroids for many years. This case is unique, because she was outside of the typical window for both chronic rejection and recurrent disease. Read More

View Article and Full-Text PDF

Predicting Kidney Response to Plasma Exchange in ANCA-Associated Vasculitis: Need for Plausible Models.

J Am Soc Nephrol 2022 Apr 11. Epub 2022 Apr 11.

Division of Pulmonary and Critical Care Medicine, Department of Medicine, and Thoracic Research Disease Unit, Mayo Clinic College of Medicine and Science, Rochester, Minnesota.

View Article and Full-Text PDF

Nutritional and Non-Nutritional Strategies in Bodybuilding: Impact on Kidney Function.

Int J Environ Res Public Health 2022 04 3;19(7). Epub 2022 Apr 3.

Centre for Health Services and Clinical Research, De Havilland Campus, University of Hertfordshire, Hatfield AL10 9EU, UK.

Bodybuilders routinely engage in many dietary and other practices purported to be harmful to kidney health. The development of acute kidney injury, focal segmental glomerular sclerosis (FSGS) and nephrocalcinosis may be particular risks. There is little evidence that high-protein diets and moderate creatine supplementation pose risks to individuals with normal kidney function though long-term high protein intake in those with underlying impairment of kidney function is inadvisable. Read More

View Article and Full-Text PDF

Over-the-counter and direct-to-consumer testing for Group A streptococcus.

Clin Biochem 2022 Apr 9. Epub 2022 Apr 9.

Department of Pathology and Laboratory Medicine, Children's Hospital of Los Angeles, Los Angeles, CA, United States; Department of Clinical Pathology, Keck School of Medicine, University of Southern California, United States. Electronic address:

Over-the-counter (OTC) and direct-to-consumer (DTC) tests have been gaining popularity due to their potential to provide accurate and quick diagnostic results without any test order from healthcare professionals, while providing patients the opportunity to actively engage in their own health management. Group A streptococcus is a common transmissible pathogen that leads to acute pharyngitis. Accurate and timely diagnosis of Group A streptococcus pharyngitis is critical to urge patients to seek professional healthcare, to support antibiotic stewardship, to reduce disease transmission, and to prevent rare but potentially life-threatening complications such as acute rheumatic fever, rheumatic heart disease, and poststreptococcal glomerulonephritis. Read More

View Article and Full-Text PDF

A Case of Immunoglobulin A (IgA)-Dominant Infection-Related Glomerulonephritis Treated With Plasmapheresis.

Cureus 2022 Mar 7;14(3):e22916. Epub 2022 Mar 7.

Department of Nephrology, Ochsner Health System, New Orleans, USA.

Immunoglobulin A (IgA)-dominant infection-related glomerulonephritis (IRGN) is mostly associated with Staphylococcal or other bacterial infections like Streptococcus and Gram-negative bacilli. Antibiotics are the cornerstone of treatment in these cases. When the bacterial infection can't be recognized or IRGN persists despite treating the underlying infection, controlling the kidney injury becomes cumbersome and lacks a strong evidence-based approach. Read More

View Article and Full-Text PDF