7,657 results match your criteria Glomerulonephritis Acute


First Report of a Disease by Rhazes 10 Centuries Ago.

Int J Prev Med 2019 15;10. Epub 2019 Jan 15.

Department of Anesthesiology and Intensive Care Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.

Introduction: Abu Bakr Mohammad Ibn Zakariya Al-Razi (865-925 CE), who was known as "Rhazes" in the west, was a famous scientist of medieval ages. He has more than 200 books and treatises. His masterpiece on medicine "" contains around 900 case reports. Read More

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http://dx.doi.org/10.4103/ijpvm.IJPVM_216_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360843PMC
January 2019

An atypical pneumonia.

Respirol Case Rep 2019 Apr 5;7(3):e00407. Epub 2019 Feb 5.

Department of Thoracic Medicine The Prince Charles Hospital Brisbane Australia.

We describe a patient with underlying HIV presenting with progressive respiratory distress and acute renal failure. A unifying diagnosis of microscopic polyangiitis was made. Following immunosuppression induction with plasma exchange and intravenous corticosteroid and subsequent maintenance immunosuppression with intravenous cyclophosphamide in conjunction with renal replacement therapy he achieved remission. Read More

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http://dx.doi.org/10.1002/rcr2.407DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363593PMC

A Controlled Human Infection Model of Group A Pharyngitis: Which Strain and Why?

mSphere 2019 Feb 13;4(1). Epub 2019 Feb 13.

Tropical Diseases, Murdoch Children's Research Institute, Melbourne, Victoria, Australia

Group A (GAS) is a major cause of global infection-related morbidity and mortality. A modern controlled human infection model (CHIM) of GAS pharyngitis can accelerate vaccine development and pathogenesis research. A robust rationale for strain selection is central to meeting ethical, scientific, and regulatory requirements. Read More

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http://dx.doi.org/10.1128/mSphere.00647-18DOI Listing
February 2019
1 Read

Association of hemophagocytic lymphohistiocytosis with kidney lesions in acute African swine fever virus infection

Ann Parasitol 2018 ;64(4):343-350

Department of Medical Biology and Parasitology, Armenia Yerevan State Medical University, 2 Koryun St., Yerevan 0025, Armenia

Glomerulonephritis due to African swine fever (ASF) is well documented. However, there is absence of good understanding of mechanisms involved in the development of pathology development. This study examines glomerulonephritis in association with acute infection induced by II genotype (Georgia 2007) of ASF virus. Read More

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January 2018
1 Read

Distinction between MPO-ANCA and PR3-ANCA-associated glomerulonephritis in Chinese patients: a retrospective single-center study.

Clin Rheumatol 2019 Feb 8. Epub 2019 Feb 8.

Jinling Clinical Medical College of Nanjing Medical University, Nanjing, China.

Objectives: To retrospectively investigate the clinical and histological features and outcomes of ANCA-associated glomerulonephritis (AAGN) with different ANCA serotypes.

Method: A total of 467 AAGN patients were divided into MPO-AAGN (MPO) and PR3-AAGN (PR3) groups according to ANCA serotype. Clinical and histological features and renal outcomes were compared. Read More

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http://dx.doi.org/10.1007/s10067-019-04458-9DOI Listing
February 2019
2 Reads

Relationship of Remodeling of Carotid Arteries and Left Ventricular Geometry in Patients With Chronic Glomerulonephritis.

Kardiologiia 2018 Nov 18;58(4):45-52. Epub 2018 Nov 18.

Кыргызская государственная медицинская академия им. И. К. Ахунбаева; Кыргызско-Российский Славянский университет им. первого Президента России Б. Н. Ельцина.

Purpose: to study clinical-functional features of remodeling of carotid arteries and its relation to restructuring of the left ventricle (LV) in patients with chronic glomerulonephritis at pre-dialysis stage.

Materials And Methods: We examined 269 patients (189 men, 80 women) with chronic glomerulonephritis (CGN) aged 17-71 years, at pre-dialysis stages of the disease. We analyzed biochemical parameters of peripheral blood with the determination of daily proteinuria and glomerular filtration rate (GFR). Read More

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http://dx.doi.org/10.18087/cardio.2018.4.10108DOI Listing
November 2018
1 Read

Relationship between serologic profile (ANCA type) and clinical features of renal involvement in ANCA-associated vasculitides.

Ter Arkh 2018 Jun;90(6):15-21

I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenov University), Moscow, Russia.

Aim: To compare the frequency, clinical features and outcomes of renal involvement in ANCA-associated vasculitides (AAV) in patients with antibodies against proteinase-3 (pr3-ANCA) and myeloperoxidase (MPO-ANCA).

Materials And Methods: In our retrospective study we enrolled 264 patients, 94 males and 170 females, median age 53 [36; 62] years. Among them 157 were pr3-ANCA positive and 107 were MPO-ANCA positive. Read More

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http://dx.doi.org/10.26442/terarkh201890615-21DOI Listing
June 2018
1 Read

Leukocytoclastic vasculitis with late-onset Henoch-Schönlein purpura after trifluridine/tipiracil treatment.

Dermatol Online J 2018 Oct 15;24(10). Epub 2018 Oct 15.

Department of Dermatology, The University of Texas McGovern Medical School, Houston, Texas.

Trifluridine/tipiracil has been approved for the treatment of refractory metastatic colorectal cancer. Adverse effects of this drug combination include leukopenia, neutropenia, fatigue, diarrhea, and vomiting. We present a case of trifluridine/tipiracil-induced leukocytoclastic vasculitis (LCV) with late-onset Henoch-Schönlein purpura (HSP) in a 42-year-old man with metastatic appendiceal cancer. Read More

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October 2018
2 Reads

Infliximab-associated focal segmental glomerulosclerosis in a patient with ankylosing spondylitis.

Rheumatol Int 2019 Mar 23;39(3):561-567. Epub 2019 Jan 23.

Division of Rheumatology, Department of Internal Medicine, Dokuz Eylul University School of Medicine, Izmir, Turkey.

The introduction of tumor necrosis factor-alpha (TNF-α)-targeting drugs has given new opportunities in the treatment of various inflammatory rheumatic diseases and has been the most important development in the treatment of spondyloarthritis (SpA). However, the increasing use and longer follow-up periods of treatment also pose risks of developing various adverse effects ranging from common ones including infections to uncommon renal complications. This report describes a case of infliximab-induced focal segmental glomerulosclerosis (FSGS) in a 40-year-old female patient with ankylosing spondylitis (AS) who presented with asymptomatic proteinuria and microscopic hematuria. Read More

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http://link.springer.com/10.1007/s00296-019-04241-8
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http://dx.doi.org/10.1007/s00296-019-04241-8DOI Listing
March 2019
5 Reads

Acute IgA-Dominant Glomerulonephritis Associated with Syphilis Infection in a Pregnant Teenager: A New Disease Association.

J Clin Med 2019 Jan 18;8(1). Epub 2019 Jan 18.

Department of Pathology, National Institute of Cardiology "Ignacio Chávez", Mexico City 14000, Mexico.

Chronic kidney disease (CKD) is increasingly recognized as a risk factor in pregnancy; the differential diagnosis between CKD and preeclampsia (PE) may be of pivotal importance for pregnancy management and for early treatment of CKD. Acknowledging this connection may be useful also in a wider context, such as in the case reported in this paper, which for the first time describes an association between syphilis infection and IgA-dominant glomerulonephritis. A 16-year-old woman, referred to a general hospital due to a seizure, was found to be unknowingly pregnant. Read More

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http://www.mdpi.com/2077-0383/8/1/114
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http://dx.doi.org/10.3390/jcm8010114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6352144PMC
January 2019
8 Reads

[Relapse of acute rheumatism fever associated with acute post-streptococcal glomerulonephritis].

Presse Med 2019 Jan 18. Epub 2019 Jan 18.

Centre hospitalier de Polynésie française, service de médecine interne et polyvalente, Tahiti, Polynésie française. Electronic address:

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http://dx.doi.org/10.1016/j.lpm.2018.11.024DOI Listing
January 2019
1 Read

The renal draining lymph nodes in acute inflammatory kidney disease.

Kidney Int 2019 Feb;95(2):254-256

Centre for Inflammatory Diseases, Monash University Department of Medicine, Monash Medical Centre, Clayton, Victoria, Australia; Department of Nephrology, Monash Health, Clayton, Victoria, Australia; Department of Clinical Immunology, Monash Health, Clayton, Victoria, Australia.

Renal lymphatics are implicated in renal disease, but their function in inflammatory kidney diseases is relatively poorly defined. In the current issue, Kasinath et al. examine the role of the kidney draining lymph node in experimental glomerulonephritis, as well the role of fibroblastic reticular cells within lymph nodes. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00852538183079
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http://dx.doi.org/10.1016/j.kint.2018.10.011DOI Listing
February 2019
6 Reads

Dabigatran causing severe acute kidney injury in a patient with liver cirrhosis.

CEN Case Rep 2019 Jan 18. Epub 2019 Jan 18.

Renal Unit, Department of Medicine, Queen Elizabeth Hospital, 30 Gascoigne Road, Kowloon, Hong Kong, SAR, China.

Anticoagulant-related nephropathy (ARN), a significant but frequently undiagnosed problem in patients receiving anticoagulation, is found to be associated with increased renal morbidity and all-cause mortality. While ARN is mainly associated with warfarin use, recent case reports suggest that it may also occur in patients taking direct oral anticoagulants (DOAC). We report a patient who had a history of alcoholic liver cirrhosis and paroxysmal atrial fibrillation, and received dabigatran 110 mg twice daily for 1 year. Read More

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http://dx.doi.org/10.1007/s13730-019-00378-4DOI Listing
January 2019
3 Reads

Pneumonia-Associated Acute Glomerulonephritis: Report of 2 Cases.

Clin Pediatr (Phila) 2019 Jan 18:9922818825157. Epub 2019 Jan 18.

1 Pediatric Nephrology Unit, Hospital Pediátrico, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal.

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http://dx.doi.org/10.1177/0009922818825157DOI Listing
January 2019
2 Reads

Reactivation of resolved hepatitis B virus infection combined with nephrotic syndrome in a patient after allogeneic haematopoietic stem cell transplantation.

BMC Infect Dis 2019 Jan 16;19(1):57. Epub 2019 Jan 16.

Department of Hematology, The Third Affiliated Hospital, Sun Yat-sen University, 600 Tianhe Road, Guangzhou, China.

Background: After allogeneic haematopoietic stem cell transplantation (allo-HSCT), Hepatitis B virus reactivation (HBVr) can be observed in patients with previous resolved Hepatitis B virus (HBV) infections. Nephrotic syndrome (NS) is the main clinical manifestation of HBsAg-positive glomerulonephritis. However, the development of HBVr combined with NS after allo-HSCT is uncommon. Read More

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http://dx.doi.org/10.1186/s12879-019-3690-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6335709PMC
January 2019
3 Reads

The role of regulatory T cells in Experimental Autoimmune Glomerulonephritis.

Am J Physiol Renal Physiol 2019 Jan 16. Epub 2019 Jan 16.

Institute of Immunology, University Medical Center Hamburg-Eppendorf, Germany.

Anti-glomerular basement membrane (anti-GBM) disease is characterized by antibodies and T cells directed against the Goodpasture antigen α3(IV)NC1 of the GBM. Consequences are the deposition of autoantibodies along the GBM and the development of crescentic glomerulonephritis (GN) with rapid loss of renal function. Foxp3 regulatory T cells (Treg cells) are crucial for the maintenance of peripheral tolerance to self-antigens and the prevention of immunopathology. Read More

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http://dx.doi.org/10.1152/ajprenal.00558.2018DOI Listing
January 2019
2 Reads

Therapy Side Effects in Systemic Lupus Erythematosus.

Curr Health Sci J 2018 Jul-Sep;44(3):316-321. Epub 2018 Jul 15.

Department of Pharmacology, University of Medicine and Pharmacy of Craiova, Romania.

Glucosteroids (GS) are widely used drugs for various inflammatory pathologies (Nephrotic syndrome, Proliferative glomerulonephritis, Extramembrane glomerulonephritis, Nephropathy of the Nodous Poliarterita (PAN), Nephropathy from purple Henoch-Schonlein, lupus nephropathy (LN), Acute adrenal insufficiency Waterhouse-Friederichsen, Chronic adrenal insufficiency Addison, Systemic Lupus Erythematosus (SLE), Polymyositis and dermatomyositis, Chronic granulomatosis, Crohn's disease, Hemorrhagic rectocolitis, Hemolytic anemias, Acute leukemias and chronic lymphocytic leukemia, Hodgkin's lymphoma). Although they are prescribed for their anti-inflammatory and immunosuppressive properties, they also have many side effects, hyperglycemia being one of the most common and representative, which is why these drugs need careful monitoring when administered over the long term. This paper presents the case of a 39 year old patient diagnosed with systemic lupus erythematosus (SLE) with class IV lupus nephropathy (LN) who developed numerous complications due to the pathogenic side effects: diabetes, amenorrhea, recurrent infections, and depression. Read More

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http://dx.doi.org/10.12865/CHSJ.44.03.18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311221PMC
July 2018
6 Reads

[Diagnosis and treatment of kidney involvement in plasma cell diseases : Renal involvement in multiple myeloma and monoclonal gammopathies].

Internist (Berl) 2019 Jan;60(1):10-22

Klinik für Nieren- und Hochdruckerkrankungen, Medizinische Hochschule Hannover, Carl-Neuberg-Str. 1, 30625, Hannover, Deutschland.

Background: Kidney involvement is a common complication in patients with plasma cell diseases.

Objective: This article outlines the spectrum of renal involvement in plasma cell dyscrasia and describes diagnostic and therapeutic measures to guide clinical management.

Material And Methods: Evaluation and discussion of the current literature as well as existing guidelines and recommendations of professional societies. Read More

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http://dx.doi.org/10.1007/s00108-018-0538-7DOI Listing
January 2019
2 Reads

Dietary Chrysin Suppresses Formation of Actin Cytoskeleton and Focal Adhesion in AGE-Exposed Mesangial Cells and Diabetic Kidney: Role of Autophagy.

Nutrients 2019 Jan 9;11(1). Epub 2019 Jan 9.

Department of Food and Nutrition, Hallym University, Chuncheon, Kangwon-do 24252, Korea.

Advanced glycation end products (AGE) play a causative role in the development of aberrant phenotypes of intraglomerular mesangial cells, contributing to acute/chronic glomerulonephritis. The aim of this study was to explore mechanistic effects of the flavonoid chrysin present in bee propolis and herbs on actin dynamics, focal adhesion, and the migration of AGE-exposed mesangial cells. The in vitro study cultured human mesangial cells exposed to 33 mM glucose and 100 μg/mL AGE-bovine serum albumin (AGE-BSA) for up to 5 days in the absence and presence of 1⁻20 μM chrysin. Read More

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http://www.mdpi.com/2072-6643/11/1/127
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http://dx.doi.org/10.3390/nu11010127DOI Listing
January 2019
5 Reads

Anticoagulant Related Nephropathy Induced by Dabigatran.

Case Rep Nephrol 2018 9;2018:7381505. Epub 2018 Dec 9.

Department of Medicine, University of Calgary, Canada.

We describe a case of biopsy-proven dabigatran related nephropathy in a patient without underlying IgA nephropathy. To date, dabigatran related nephropathy was only reported in patients with concurrent or undiagnosed IgA nephropathy, suggesting that it may predispose patients to dabigatran associated injury. The patient is an 81-year-old woman with multiple medical comorbidities, including nonvalvular atrial fibrillation, who was anticoagulated with dabigatran. Read More

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http://dx.doi.org/10.1155/2018/7381505DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304482PMC
December 2018
4 Reads

Recurrence of Goodpasture syndrome without circulating anti-glomerular basement membrane antibodies after kidney transplant, a case report.

BMC Nephrol 2019 Jan 8;20(1). Epub 2019 Jan 8.

Department of Nephrology, CHU Rennes, Rennes, France.

Background: Goodpasture Syndrome (GS) is an autoimmune disease caused by the development of auto-antibodies against the Glomerular Basement Membrane (GBM). Linear deposit of immunoglobulins G on the GBM detected by immunofluorescence analysis of renal biopsies is a GS pathognomonic finding. GS is commonly monophasic and its incidence is 1. Read More

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https://bmcnephrol.biomedcentral.com/articles/10.1186/s12882
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http://dx.doi.org/10.1186/s12882-018-1197-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323659PMC
January 2019
5 Reads

Protective Effects of Epigallocatechin-3-Gallate from Green Tea in Various Kidney Diseases.

Adv Nutr 2019 Jan;10(1):112-121

Medical Proteomics Unit, Office for Research and Development, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.

Kidney diseases are common health problems worldwide. Various etiologies (e.g. Read More

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https://academic.oup.com/advances/advance-article/doi/10.109
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http://dx.doi.org/10.1093/advances/nmy077DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6370267PMC
January 2019
16 Reads

Nephrotoxicity of immune checkpoint inhibitors beyond tubulointerstitial nephritis: single-center experience.

J Immunother Cancer 2019 Jan 6;7(1). Epub 2019 Jan 6.

Division of Internal Medicine, Section of Nephrology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd., Unit 1468, Houston, TX, 77030, USA.

Rationale & Objective: The approved therapeutic indication for immune checkpoint inhibitors (CPIs) are rapidly expanding including treatment in the adjuvant setting, the immune related toxicities associated with CPI can limit the efficacy of these agents. The literature on the nephrotoxicity of CPI is limited. Here, we present cases of biopsy proven acute tubulointerstitial nephritis (ATIN) and glomerulonephritis (GN) induced by CPIs and discuss potential mechanisms of these adverse effects. Read More

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https://jitc.biomedcentral.com/articles/10.1186/s40425-018-0
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http://dx.doi.org/10.1186/s40425-018-0478-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322290PMC
January 2019
10 Reads

Acute renal failure in a patient with PR3-ANCA and monoclonal immunoglobulin deposition disease: Case report.

Medicine (Baltimore) 2018 Dec;97(52):e13799

Institute of Health Policy, Management, and Evaluation, University of Toronto, Canada.

Rationale: Acute renal failure developing over a short period of time with evidence of glomerular disease by urine sediment microscopy characterizes the clinical syndrome of rapidly progressive glomerulonephritis (RPGN), of which the most common causes are ANCA-associated glomerulonephritis (GN), immune-complex mediated GN and anti-GBM disease.

Patient Concerns: This was a middle-aged gentleman who presented with acute renal failure and a positive PR3-ANCA.

Diagnosis: Renal biopsy showed an unusual combination of PR3-ANCA GN with focal crescents, monoclonal immunoglobulin deposition disease (MIDD) and mesangial IgA deposition on renal biopsy. Read More

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http://Insights.ovid.com/crossref?an=00005792-201812280-0004
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http://dx.doi.org/10.1097/MD.0000000000013799DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6314724PMC
December 2018
3 Reads

Clinicopathological profile of pediatric renal biopsies at a tertiary care hospital, Pakistan.

Saudi J Kidney Dis Transpl 2018 Nov-Dec;29(6):1403-1409

The Kidney Center, Karachi, Pakistan.

Renal biopsy is an important tool for the diagnosis of acute and chronic glomerular diseases in children. We aimed to analyze the spectrum of clinical indications and histopathological patterns (HPP) in children who underwent renal biopsy (RB). This is a retrospective review of case records of 108 renal biopsies carried out from January 2010 to December 2015 at the Pediatric Nephrology Department, National Institute of Child Health Karachi, Pakistan. Read More

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http://www.sjkdt.org/text.asp?2018/29/6/1403/248290
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http://dx.doi.org/10.4103/1319-2442.248290DOI Listing
December 2018
13 Reads

IgA nephropathy with diffuse alveolar haemorrhage.

BMJ Case Rep 2018 Dec 22;11(1). Epub 2018 Dec 22.

Department of Pulmonary Medicine, Yokkaichi Municipal Hospital, Yokkaichi, Japan.

Immunoglobulin (Ig)A nephropathy is the most common cause of primary glomerulonephritis worldwide. While IgA nephropathy has been associated with a variety of other diseases, pulmonary complications are extremely rare. A 58-year-old man presented with a 2-week history of fever and exertional dyspnoea. Read More

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http://dx.doi.org/10.1136/bcr-2018-227382DOI Listing
December 2018
2 Reads

Development of Focal Segmental Glomerulosclerosis and Thrombotic Microangiopathy in a Liver Transplant Patient on Sorafenib for Hepatocellular Carcinoma: A Case Report.

Transplant Proc 2018 Dec;50(10):4033-4037

Department of Medicine, Division of Nephrology, University of California Los Angeles (UCLA), Westwood, CA; UCLA Liver Transplant Surgery, Westwood, CA.

Transplant patients are at risk for hemodynamic injury and glomerular diseases such as focal segmental glomerulosclerosis (FSGS) and thrombotic microangiopathy (TMA). Calcineurin inhibitors (CNI) can cause various patterns of acute kidney injury (AKI) in transplant patients and their effects must be differentiated from kidney injury due to other agents. Transplant populations are also at risk for atypical infections and malignancies. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00411345183082
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http://dx.doi.org/10.1016/j.transproceed.2018.07.020DOI Listing
December 2018
8 Reads

Being Overweight Is Related to Faster Decline in Annual Glomerular Filtration Rate in Kidney Transplant.

Transplant Proc 2018 Dec 18;50(10):3392-3396. Epub 2018 Apr 18.

Centro de Nefrología, Hospital de Clínicas, Facultad de Medicina, UdeLaR, Montevideo, Uruguay.

Few studies have examined the relationship between non-immunological factors and glomerular filtration rate (GFR) decline in kidney transplant. Correcting these factors in native kidneys slows the progression of chronic kidney disease. The aim of this study was to analyze the association between the control of non-immunological factors and the annual decline of GFR. Read More

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http://dx.doi.org/10.1016/j.transproceed.2018.04.040DOI Listing
December 2018
2 Reads

Characteristics and Outcomes of Kidney Transplant Recipients with a Functioning Graft for More than 25 Years.

Kidney Dis (Basel) 2018 Nov 27;4(4):255-261. Epub 2018 Jul 27.

Division of Nephrology, Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.

Background: Information regarding the clinical characteristics and outcomes of kidney transplant recipients (KTRs) with > 25 years of graft survival is limited.

Methods: In this single-center observational study, we characterized KTRs transplanted between 1973 and 1992 with active follow-up as of July 31, 2017.

Results: We identified 112 patients with > 25 years of allograft function. Read More

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http://dx.doi.org/10.1159/000491575DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276752PMC
November 2018
1 Read

MIF in kidney diseases : A story of Dr. Jekyll and Mr. Hyde.

Authors:
P Boor

Pathologe 2018 Dec 19. Epub 2018 Dec 19.

Institute of Pathology, University Clinic, RWTH University of Aachen, Pauwelsstr. 30, 52074, Aachen, Germany.

Background: Macrophage migration-inhibitory factor (MIF) is a cytokine best known for its proinflammatory and disease-aggravating role in a number of conditions, including atherosclerosis, autoimmune diseases, sepsis, and glomerulonephritides.

Objectives: In our studies we aimed to define the role of MIF on local renal resident cells, in particular the renal epithelium.

Results: We have shown that MIF exerts local effects on glomerular cells, in particular the parietal epithelial cells and mesangial cells, promoting their pathological proliferation and aggravating disease course of a murine model of immune-mediated glomerulonephritis. Read More

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http://link.springer.com/10.1007/s00292-018-0548-1
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http://dx.doi.org/10.1007/s00292-018-0548-1DOI Listing
December 2018
13 Reads

Successful management of proliferative glomerulonephritis with monoclonal immune deposits with combined immunosuppressive therapy.

BMJ Case Rep 2018 Dec 7;11(1). Epub 2018 Dec 7.

Nephrology, Allegheny Health Network, Pittsburgh, Pennsylvania, USA.

Proliferative glomerulonephritis with monoclonal immune deposits (PGNMID) is a newly described entity characterised by monoclonal IgG deposits consisting of single light chain isotype and single heavy chain subtype (IgG1-4) in the kidneys. We are presenting two cases of patients who presented with acute kidney injury and worsening proteinuria. Kidney biopsy showed membranoproliferative pattern. Read More

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http://dx.doi.org/10.1136/bcr-2018-225205DOI Listing
December 2018
3 Reads

Infection-Induced Kidney Diseases.

Front Med (Lausanne) 2018 28;5:327. Epub 2018 Nov 28.

Department of Nephrology and Renal Transplantation, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India.

Infection induced kidney diseases are of concern for clinicians because timely detection and treatment of infections may cure or limit the extent of injury inflicted by microorganisms causing the infections. Infections can cause kidney injury by either direct invasion, or indirectly by immune mediated mechanisms, which manifest as post-infectious glomerulonephritis, or infection-related glomerulonephritis. Clinical manifestations may be acute or chronic depending on the microorganisms, endemic/epidemic nature and source of infection. Read More

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http://dx.doi.org/10.3389/fmed.2018.00327DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6282040PMC
November 2018
1 Read

Surgical outcomes of acute type A aortic dissection in dialysis patients.

Gen Thorac Cardiovasc Surg 2018 Dec 14. Epub 2018 Dec 14.

Department of Cardiovascular Surgery, Saitama Medical Center, Jichi Medical University, 1-847 Amanumacho, Omiya-ku, Saitama, 330-8503, Japan.

Background: Acute type A aortic dissection (ATAAD) is relatively uncommon in dialysis patients, and characteristics and repair outcomes are not fully understood.

Patients And Methods: Patients with ATAAD (n = 960) were divided into a dialysis group (n = 19) and non-dialysis group (n = 941), depending on whether they required dialysis for preoperative end-stage renal disease (ESRD). Hospital charts and imaging data were reviewed, and characteristics and outcomes were compared between the groups. Read More

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http://dx.doi.org/10.1007/s11748-018-1051-6DOI Listing
December 2018
2 Reads

Juvenile dermatomyositis with IgA nephropathy: case-based review.

Rheumatol Int 2019 Mar 14;39(3):577-581. Epub 2018 Dec 14.

Department of Pathology, All India Institute of Medical Sciences, New Delhi, India.

Juvenile dermatomyositis (JDM) is the most common childhood idiopathic inflammatory myopathy (IIM). It is characterized by the classic skin rash in the form of Gottron papules and heliotrope rash, and symmetric proximal muscle weakness. Renal involvement in JDM is rare which includes acute kidney injury and glomerulonephritis. Read More

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http://dx.doi.org/10.1007/s00296-018-4229-4DOI Listing
March 2019
11 Reads

Bevacizumab-associated glomerular microangiopathy.

Mod Pathol 2018 Dec 14. Epub 2018 Dec 14.

Institute of Pathology and Nephropathology Section, University Hospital Hamburg Eppendorf, Hamburg, Germany.

Bevacizumab is a humanized monoclonal IgG1 antibody, which neutralizes vascular endothelial growth factor and is used for treating multiple cancer types. As a known and frequent adverse event, this therapy can lead to renal damage including proteinuria and nephrotic syndrome. In a retrospective approach, we analyzed 17 renal biopsies from patients receiving bevacizumab treatment. Read More

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http://dx.doi.org/10.1038/s41379-018-0186-4DOI Listing
December 2018
1 Read

Platelet retention in inflamed glomeruli occurs via selective prolongation of interactions with immune cells.

Kidney Int 2019 Feb 3;95(2):363-374. Epub 2018 Dec 3.

Centre for Inflammatory Diseases, Monash University Department of Medicine, Monash Medical Centre, Clayton, Victoria, Australia. Electronic address:

Platelet-leukocyte interactions promote acute glomerulonephritis. However, neither the nature of the interactions between platelets and immune cells nor the capacity of platelets to promote leukocyte activation has been characterized in this condition. We used confocal intravital microscopy to define the interactions of platelets with neutrophils, monocytes, and endothelial cells in glomerular capillaries in mice. Read More

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http://dx.doi.org/10.1016/j.kint.2018.08.042DOI Listing
February 2019
1 Read
8.563 Impact Factor

Activation of fibroblastic reticular cells in kidney lymph node during crescentic glomerulonephritis.

Kidney Int 2019 Feb 3;95(2):310-320. Epub 2018 Dec 3.

Transplantation Research Center, Brigham and Women's Hospital, Boston, Massachusetts, USA; Division of Renal Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA. Electronic address:

Crescentic glomerulonephritis is an inflammatory condition characterized by rapid deterioration of kidney function. Previous studies of crescentic glomerulonephritis have focused on immune activation in the kidney. However, the role of fibroblastic reticular cells, which reside in the stromal compartment of the kidney lymph node, has not been studied in this condition. Read More

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http://dx.doi.org/10.1016/j.kint.2018.08.040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6342621PMC
February 2019
2 Reads

Inflammasomes in the Kidney.

Exp Suppl 2018 ;108:177-210

Centre for Inflammatory Diseases, Monash University Department of Medicine, Monash Medical Centre, Clayton, VIC, Australia.

Inflammasomes influence a diverse range of kidney disease, including acute and chronic kidney diseases, and those mediated by innate and adaptive immunity. Both IL-18 and in particular IL-1β are validated therapeutic targets in several kidney diseases. In addition to leukocyte-derived inflammasomes, renal tissue cells express functional inflammasome components. Read More

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http://dx.doi.org/10.1007/978-3-319-89390-7_8DOI Listing
January 2018
2 Reads

Extracellular traps in kidney disease.

Kidney Int 2018 Dec;94(6):1087-1098

Division of Nephrology, Medizinische Klinik und Poliklinik IV, Klinikum der Universität München, LMU München, Germany. Electronic address:

During the past decade the formation of neutrophil extracellular traps (NETs) has been recognized as a unique modality of pathogen fixation (sticky extracellular chromatin) and pathogen killing (cytotoxic histones and proteases) during host defense, as well as collateral tissue damage. Numerous other triggers induce NET formation in multiple forms of sterile inflammation, including thrombosis, gout, obstruction of draining ducts, and trauma. Whether neutrophils always die along with NET release, and if they do die, how, remains under study and is most likely context dependent. Read More

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http://dx.doi.org/10.1016/j.kint.2018.08.035DOI Listing
December 2018
8 Reads

Renal dysfunction in Leishmaniasis and Chagas disease coinfection: a case report.

Rev Inst Med Trop Sao Paulo 2018 Nov 14;60:e73. Epub 2018 Nov 14.

Universidade Federal do Ceará, Faculdade de Medicina, Fortaleza, Ceará, Brazil.

Visceral leishmaniasis (VL) is an endemic parasitic disease frequently found in Northeast Brazil and may cause acute kidney injury (AKI) and glomerulonephritis. After appropriate treatment, renal function recovery may occur. We describe the rare case of a patient with VL, who developed severe AKI requiring dialysis and was subsequently diagnosed with Chagas disease coinfection. Read More

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http://dx.doi.org/10.1590/S1678-9946201860073DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6235430PMC
November 2018
1 Read

Infection-Related Glomerulonephritis.

Pediatr Clin North Am 2019 02;66(1):59-72

Division of Nephrology, Boston Children's Hospital, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA.

Acute postinfectious glomerulonephritis or infection-related glomerulonephritis has been associated with several viral or bacterial infections. Group A beta-hemolytic streptococcal infection is the prototypical cause of postinfectious glomerulonephritis and the main focus of this discussion. The clinical spectrum can vary widely, from asymptomatic microscopic hematuria incidentally detected on routine urinalysis to rapidly progressive glomerulonephritis with acute kidney injury requiring emergent dialysis. Read More

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http://dx.doi.org/10.1016/j.pcl.2018.08.005DOI Listing
February 2019
9 Reads

The role of eicosanoids in renal diseases - potential therapeutic possibilities.

Acta Biochim Pol 2018 Nov;65(4):479-486

Pomeranian Medical University, Department of Nephrology, Transplantology and Internal Medicine.

Eicosanoids are biologically active molecules that are created in the process of oxidation of arachidonic acid (AA) which is a constituent of the cell membrane phospholipids. Throughout the years it was evidenced by experiments that the lipid and lipid-derived metabolites play an important role in physiological and pathological processes in the kidneys. They are being considered as biomarkers in detecting acute kidney injury, nephrotoxicity, glomerulonephritis and early stages of diabetic nephropathy because of their participation in inflammatory processes and in oxidative stress. Read More

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http://dx.doi.org/10.18388/abp.2018_2609DOI Listing
November 2018
11 Reads

Hydralazine-associated antineutrophil cytoplasmic antibody vasculitis with pulmonary-renal syndrome.

BMJ Case Rep 2018 Nov 8;2018. Epub 2018 Nov 8.

Nephrology, Deaconess Health System, Evansville, Indiana, USA.

Hydralazine, a vasodilator, is commonly used as an adjunctive treatment for moderate to severe hypertension, heart failure and hypertensive emergencies in pregnancy. Hydralazine-induced lupus was first described in 1953. Clinical presentation ranges from arthralgia, myalgia, petechiae, or rash to single or multiorgan involvement. Read More

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http://casereports.bmj.com/lookup/doi/10.1136/bcr-2018-22716
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http://dx.doi.org/10.1136/bcr-2018-227161DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6229221PMC
November 2018
7 Reads

Nephrotic syndrome associated with Kimura's disease: a case report and literature review.

BMC Nephrol 2018 Nov 8;19(1):316. Epub 2018 Nov 8.

Department of Nephrology, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, No.32, West Section 2, Ring 1 Road, Chengdu, 610072, Sichuan, China.

Background: Kimura's disease (KD) is a rare chronic inflammatory disorder with a high incidence of renal involvement. In this report, we present a case study of KD-associated nephrotic syndrome combined with minimal change disease (MCD) and acute renal tubular injury. Meanwhile, the clinical and histopathological characteristics of 26 patients with KD presenting with renal involvement were retrospectively evaluated. Read More

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http://dx.doi.org/10.1186/s12882-018-1123-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6225567PMC
November 2018
6 Reads
1.520 Impact Factor

[MIF in kidney diseases : A story of Dr. Jekyll and Mr. Hyde (German version)].

Authors:
P Boor

Pathologe 2018 Dec;39(Suppl 2):177-184

Institut für Pathologie, Universitätsklinikum der RWTH Aachen, Pauwelsstraße 30, 52074, Aachen, Deutschland.

Background: Macrophage migration-inhibitory factor (MIF) is a cytokine best known for its proinflammatory and disease-aggravating role in a number of conditions, including atherosclerosis, autoimmune diseases, sepsis, and glomerulonephritides.

Objectives: In our studies we aimed to define the role of MIF on local renal resident cells, in particular the renal epithelium.

Results: We have shown that MIF exerts local effects on glomerular cells, in particular the parietal epithelial cells and mesangial cells, promoting their pathological proliferation and aggravating disease course of a murine model of immune-mediated glomerulonephritis. Read More

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http://link.springer.com/10.1007/s00292-018-0535-6
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http://dx.doi.org/10.1007/s00292-018-0535-6DOI Listing
December 2018
10 Reads

Acute Post-Streptococcal Glomerulonephritis in the Northern Territory of Australia: A Review of Data from 2009 to 2016 and Comparison with the Literature.

Am J Trop Med Hyg 2018 Dec;99(6):1643-1648

Department of Health, Centre for Disease Control, Darwin, Australia.

Acute post-streptococcal glomerulonephritis (APSGN) is an inflammatory kidney disease following infection with nephritogenic strains of Group A . In 1991, APSGN became notifiable in the Northern Territory (NT) of Australia with cases recorded on the NT Notifiable Disease Database (NTNDS). The case definition of a confirmed case requires laboratory definitive evidence or laboratory suggestive evidence in conjunction with a clinically compatible illness. Read More

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http://dx.doi.org/10.4269/ajtmh.18-0093DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6283515PMC
December 2018
3 Reads

Exclusive expression of transmembrane TNF aggravates acute glomerulonephritis despite reduced leukocyte infiltration and inflammation.

Kidney Int 2019 Jan 30;95(1):75-93. Epub 2018 Oct 30.

Nephrologisches Zentrum, Medizinische Klinik und Poliklinik IV, Klinikum der Universität München, Ludwig-Maximilians-Universität München, Munich, Germany. Electronic address:

Tumor necrosis factor-α (TNF) is a cytokine mediating inflammatory kidney diseases such as immune complex glomerulonephritis. Its two receptors, TNFR1 and TNFR2, play distinct roles in this process, with TNFR2 strongly required for induction of disease. In contrast to soluble TNF (sTNF), transmembrane TNF robustly activates TNFR2. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00852538183059
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http://dx.doi.org/10.1016/j.kint.2018.08.012DOI Listing
January 2019
10 Reads

Infection-Related Glomerular Disease.

Authors:
Maria A Revell

Nurs Clin North Am 2018 12 11;53(4):541-549. Epub 2018 Oct 11.

School of Nursing, Tennessee State University, 3500 John A. Merritt Boulevard, Campus Box 9590, Nashville, TN 37132, USA. Electronic address:

Glomerular disease results from a complex process. It can occur following acute illnesses or chronic diseases from other organs and body parts that promote bacterial invasion. Assessment and initial identification of the cause of this process is important in order to initiate interventions that promote a return to wellness. Read More

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http://dx.doi.org/10.1016/j.cnur.2018.07.005DOI Listing
December 2018
2 Reads

Acute glomerulonephritis triggered by parvovirus B19.

Tidsskr Nor Laegeforen 2018 10 23;138(17). Epub 2018 Oct 23.

Background: Para- and post-infectious glomerulonephritis may be caused by various microbiological agents. We present a case of parvovirus B19 infection causing a post-infectious glomerulonephritis.

Case Presentation: A 30-year-old woman was admitted to hospital after four weeks of fever, flank pain and general oedema. Read More

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http://dx.doi.org/10.4045/tidsskr.18.0043DOI Listing
October 2018
2 Reads

Bacterial endocarditis manifesting as autoimmune pulmonary renal syndrome: ANCA-associated lung hemorrhage and pauci-immune crescentic glomerulonephritis
.

Clin Nephrol 2018 Dec;90(6):431-433

The etiology of pulmonary renal syndrome can be broadly divided into infectious and autoimmune (predominantly ANCA vasculitis). The importance of timely differentiating between them stems from the deleterious effects of their respective treatment if misdiagnosed. Serology and tissue evaluation by pathology are employed to aid in this, however, in rare cases, this can be difficult. Read More

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http://dx.doi.org/10.5414/CN109495DOI Listing
December 2018
14 Reads