8,212 results match your criteria Glomerulonephritis Acute

Epidemiology of biopsy-proven glomerulonephritis in the past 25 years in the North-Eastern area of Romania.

Int Urol Nephrol 2021 May 15. Epub 2021 May 15.

Nephrology Clinic, Dialysis and Renal Transplant Center, 'C.I. Parhon' University Hospital, and "Grigore T. Popa" University of Medicine, Iasi, Romania.

Purpose: The aim of this retrospective study was: to analyze the epidemiological patterns of the kidney disease based on clinical and histological features in a single-center in the N-E region of Romania, between 2011 and 2019 and to compare the biopsy results with the others periods, as well as the results from other countries.

Methods: We studied 442 renal biopsies. The indications for renal biopsy were represented by the clinical features: nephrotic syndrome, nephritic syndrome, asymptomatic urinary abnormalities, acute kidney injury, and chronic kidney disease of unknown etiology. Read More

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[Metastatic Pulmonary Calcification: A Rare Entity in the Differential Diagnosis Examination of Interstitial Lung Diseases].

Pneumologie 2021 May 11. Epub 2021 May 11.

Institut für diagnostische und interventionelle Radiologie, Ammerlandklinik Westerstede.

A 70-year-old patient who received a kidney transplant about 20 years ago due to anti-neutrophil cytoplasmic antibody (ANCA)-positive, rapidly progressive glomerulonephritis was assigned to us for an evaluation of fibrosing interstitial lung disease with computer tomography (CT)-radiological changes assigned to acute alveolitis. She complained about long-term exertional dyspnea. In terms of lung function, there was some slight restriction (FVC 78 % of the target), and pronounced severe diffusion disorder (DLCO 41 % of the target). Read More

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Dengue Virus Infection Presenting as Membranoproliferative Glomerulonephritis Type 1.

Cureus 2021 Apr 5;13(4):e14294. Epub 2021 Apr 5.

Department of Medicine, Dr Soliman Fakeeh Hospital, Jeddah, SAU.

The renal complications of dengue virus infection cover a wide spectrum of manifestations from acute kidney injury to glomerular injury with nephritic/nephrotic syndrome. Majority of cases remain symptom free and show full recovery. We present a 61-year-old previously healthy male who developed a pyrexial illness with haemolytic anaemia that was diagnosed on the basis of a positive serological test as a case of dengue fever. Read More

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A brief review on Group A Streptococcus pathogenesis and vaccine development.

R Soc Open Sci 2021 Mar 10;8(3):201991. Epub 2021 Mar 10.

Division of Molecular Microbiology, School of Life Sciences, University of Dundee, Dow Street, Dundee, DD1 5EH, UK.

, also known as Group A Streptococcus (GAS), is a Gram-positive human-exclusive pathogen, responsible for more than 500 000 deaths annually worldwide. Upon infection, GAS commonly triggers mild symptoms such as pharyngitis, pyoderma and fever. However, recurrent infections or prolonged exposure to GAS might lead to life-threatening conditions. Read More

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Fatal hemoperitoneum due to rupture of mesenteric artery in remission state of microscopic polyangiitis, concomitant with severe hypertension and posterior reversible encephalopathy syndrome: an autopsy case report.

CEN Case Rep 2021 May 4. Epub 2021 May 4.

Department of Pathology and Oncology, School of Medicine, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu, Fukuoka, Japan.

Microscopic polyangiitis (MPA) is a type of necrotizing vasculitis associated with high levels of myeloperoxidase-specific antineutrophil cytoplasmic antibody (MPO-ANCA). While generally associated with renal dysfunction, MPA can also cause intraabdominal hemorrhage in rare cases. A 66-year-old man was admitted to our hospital for renal dysfunction, numbness, and weight loss for 3 months. Read More

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Interleukin-12 exacerbates symptoms in an MRL/MpJ-Faslpr mouse model of systemic lupus erythematosus.

Exp Ther Med 2021 Jun 15;21(6):627. Epub 2021 Apr 15.

Institute of Acute Disorders of Traditional Chinese Internal Medicine, The First Clinical College of Nanjing University of Chinese Medicine, Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210023, P.R. China.

Interleukin (IL)-12 modulates the generation and function of a variety of immune cells and serves an important role in the pathogenesis of autoimmune diseases. However, the precise role of IL-12 in the pathogenesis of systemic lupus erythematosus (SLE) remains to be elucidated. In the present study, the serum levels of IL-12 in patients with SLE were determined using an ELISA. Read More

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Extracellular vesicles in renal inflammatory and infectious diseases.

Free Radic Biol Med 2021 Apr 29;171:42-54. Epub 2021 Apr 29.

Department of Pediatrics, Clinical Sciences Lund, Lund University, 22185, Lund, Sweden.

Extracellular vesicles can mediate cell-to-cell communication, or relieve the parent cell of harmful substances, in order to maintain cellular integrity. The content of extracellular vesicles includes miRNAs, mRNAs, growth factors, complement factors, cytokines, chemokines and receptors. These may contribute to inflammatory and infectious diseases by the exposure or transfer of potent effectors that induce vascular inflammation by leukocyte recruitment and thrombosis. Read More

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Nephrotoxicity as a Complication of Chemotherapy and Immunotherapy in the Treatment of Colorectal Cancer, Melanoma and Non-Small Cell Lung Cancer.

Int J Mol Sci 2021 Apr 28;22(9). Epub 2021 Apr 28.

Department of Nephrology, Hypertension and Family Medicine, Medical University of Łódź, Żeromskiego 113, 90-549 Łódź, Poland.

Acute kidney injury is a common complication of many medical procedures, including those used in cancer treatment. Both chemotherapy and immunotherapy may result in deterioration of kidney function, which may lead to an increase in mortality among patients with cancer. Antineoplastic agents can affect any element of the nephron, leading to the appearance of clinical symptoms such as proteinuria, hypertension, electrolyte disorders, glomerulonephritis, acute and chronic interstitial nephritis and acute kidney injury. Read More

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Renal Diseases Associated with Hematologic Malignancies and Thymoma in the Absence of Renal Monoclonal Immunoglobulin Deposits.

Diagnostics (Basel) 2021 Apr 15;11(4). Epub 2021 Apr 15.

Assistance Publique des Hôpitaux de Paris (AP-HP), Hôpitaux Universitaires Henri Mondor, Service de Néphrologie et Transplantation, Centre de Référence Maladie Rare "Syndrome Néphrotique Idiopathique", Fédération Hospitalo-Universitaire "Innovative Therapy for Immune Disorders", 94000 Créteil, France.

In addition to kidney diseases characterized by the precipitation and deposition of overproduced monoclonal immunoglobulin and kidney damage due to chemotherapy agents, a broad spectrum of renal lesions may be found in patients with hematologic malignancies. Glomerular diseases, in the form of paraneoplastic glomerulopathies and acute kidney injury with various degrees of proteinuria due to specific lymphomatous interstitial and/or glomerular infiltration, are two major renal complications observed in the lymphoid disorder setting. However, other hematologic neoplasms, including chronic lymphocytic leukemia, thymoma, myeloproliferative disorders, Castleman disease and hemophagocytic syndrome, have also been associated with the development of kidney lesions. Read More

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Proteinuria Indicates Decreased Normal Glomeruli in ANCA-Associated Glomerulonephritis Independent of Systemic Disease Activity.

J Clin Med 2021 Apr 6;10(7). Epub 2021 Apr 6.

Department of Nephrology and Rheumatology, University Medical Center Göttingen, 37075 Göttingen, Germany.

Background: Renal involvement is a common and severe complication of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV), potentially resulting in a pauci-immune necrotizing and crescentic ANCA glomerulonephritis (GN) with acute kidney injury (AKI), end-stage renal disease (ESRD) or death. There is recent evidence that the degree of proteinuria at diagnosis is associated with long-term renal outcome in ANCA GN. Therefore, we here aimed to systematically describe the association between proteinuria and clinicopathological characteristics in 53 renal biopsies with ANCA GN and corresponding urinary samples at admission. Read More

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Improved transformation efficiency of group A Streptococcus by inactivation of a type I restriction modification system.

PLoS One 2021 29;16(4):e0248201. Epub 2021 Apr 29.

Division of Infectious Diseases, Boston Children's Hospital and Department of Pediatrics, Harvard Medical School, Boston, Massachusetts, United States of America.

Streptococcus pyogenes or group A Streptococcus (GAS) is a leading cause of bacterial pharyngitis, skin and soft tissue infections, life-threatening invasive infections, and the post-infectious autoimmune syndromes of acute rheumatic fever and post-streptococcal glomerulonephritis. Genetic manipulation of this important pathogen is complicated by resistance of the organism to genetic transformation. Very low transformation efficiency is attributed to recognition and degradation of introduced foreign DNA by a type I restriction-modification system encoded by the hsdRSM locus. Read More

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Renal elastography measurements in children with acute glomerulonephritis.

Ultrasonography 2021 Mar 4. Epub 2021 Mar 4.

Department of Radiology, Faculty of Medicine, Gaziantep University, Üniversite Bulvarı, Șehitkamil, Turkey.

Purpose: The aim of this study was to compare the acoustic radiation force impulse elastography (ARFI-e) values of the renal cortical parenchyma in children with acute glomerulonephritis (AGN) and healthy children, and to determine a cut-off point for the diagnosis of AGN.

Methods: This prospective study included 30 children with biopsy-proven AGN and 30 healthy children. All the children underwent renal ARFI-e measurements. Read More

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Crescentic postinfectious glomerulonephritis in an adult patient with juvenile nasopharyngeal angiofibroma.

BMJ Case Rep 2021 Apr 23;14(4). Epub 2021 Apr 23.

Division of Nephrology, Department of Medicine, University of the Philippines Manila, Manila, Philippines.

Crescentic glomerulonephritis is usually associated with an acute nephritic syndrome with rapidly declining renal function. Postinfectious cases usually have a higher possibility of recovery. Juvenile nasopharyngeal angiofibroma (JNA) is a rare, locally aggressive tumour affecting mostly young men. Read More

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Acute Severe Renal Artery Stenosis Presenting as Acute Kidney Injury with Severe Hypertension, and Active Urine Sediment.

Can J Cardiol 2021 Apr 20. Epub 2021 Apr 20.

Division of Nephrology, Department of Medicine, The Ottawa Hospital, University of Ottawa. Electronic address:

We present a case of severe renal artery stenosis that mimicked a rapidly progressive glomerulonephritis with acute kidney injury, active urine sediments and severe hypertension. Simultaneous presence of secondary hyperaldosteronism and hypokalemia prompted renal angiogram and subsequent renal artery angioplasty and stenting, thus leading to rapid resolution of acute kidney injury, proteinuria, and hypertension. Our case emphasizes the importance and benefits of prompt diagnosis and revascularization of acute severe renal artery stenosis in a patient with history of atherosclerotic renovascular disease presenting with sudden onset of severe hypertension and acute kidney injury with active urine sediment mimicking rapidly progressive glomerulonephritis. Read More

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Posterior reversible encephalopathy syndrome associated with focal segmental glomerulosclerosis in a child.

BMJ Case Rep 2021 Apr 14;14(4). Epub 2021 Apr 14.

Department of Radiology, Notre Dame des Secours University Hospital Center, Jbeil, Mont-Liban, Lebanon.

Posterior reversible encephalopathy syndrome (PRES) is a rare neurological entity, typically manifested by reversible oedema in the parieto-occipital lobes. It is usually associated with primary hypertension, autoimmune diseases and immunosuppressants. Renal disease is an uncommon cause of PRES. Read More

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Kidney Injury in Multiple Myeloma: A Kidney Biopsy Teaching Case.

Kidney Med 2021 Mar-Apr;3(2):303-306. Epub 2021 Feb 5.

Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN.

Myeloma-related kidney disease has several manifestations; the 2 most common histologic diagnoses are myeloma cast nephropathy and acute tubular necrosis. We describe a case of different kidney pathologies occurring concomitantly in a patient found to have immunoglobulin A κ multiple myeloma. A White woman in her 70s presented with an 8-month history of back pain and was found to have nephrotic-range proteinuria and acute kidney injury. Read More

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February 2021

Lupus-Like Glomerulonephritis Associated With Regorafenib, a Multikinase Inhibitor.

Kidney Med 2021 Mar-Apr;3(2):294-298. Epub 2021 Feb 5.

Section of Nephrology, Division of Internal Medicine, University of Texas MD Anderson Cancer Center, Houston, TX.

Drug-induced lupus glomerular diseases have historically been associated with hydralazine, but new drugs that modify the growth, metabolism, and immunity of cells are increasingly found to cause glomerular disease. This includes anti-tumor necrotic factor and other antibody agents used in cancer treatment. Multitarget tyrosine kinases such as regorafenib are increasingly used in metastatic malignancies with good outcomes. Read More

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February 2021

Does withdrawal of immunosuppression in rheumatoid arthritis after SARS-CoV-2 infection increase the risk of vasculitis?

BMJ Case Rep 2021 Apr 12;14(4). Epub 2021 Apr 12.

Division of Rheumatology, Department of Medicine, UF Health Jacksonville, Jacksonville, Florida, USA.

We describe a case of a 48-year-old woman who presented with acute respiratory failure due to diffuse alveolar haemorrhage and acute renal failure due to pauci-immune glomerulonephritis consistent with a new diagnosis of microscopic polyangiitis (MPA). The patient had a recent SARS-CoV-2 infection 6 weeks before MPA diagnosis and had stopped immunosuppression for her rheumatoid arthritis (RA) at that time. The patient was treated with pulse intravenous steroids, plasma exchange therapy and rituximab, which induced remission of her illness. Read More

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Microscopic Polyangiitis With Diffuse Alveolar Hemorrhage and Glomerulonephritis Complicating Acute Influenza Infection.

J Clin Rheumatol 2021 Mar 25. Epub 2021 Mar 25.

From the Division of Rheumatology, Allergy, and Clinical Immunology Division of Infectious Diseases and Global Medicine Department of Pathology, Immunology, and Laboratory Medicine Department of Dermatology Division of Pulmonary and Critical Care Medicine, University of Florida, Gainesville, FL.

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A 10-year Study: Renal Outcomes in Patients with Accelerated Hypertension and Renal Dysfunction.

Indian J Nephrol 2020 Nov-Dec;30(6):409-415. Epub 2020 Nov 7.

Department of Nephrology, Manipal Hospital, Old HAL Airport Road, Bengaluru, Karnataka, India.

Background: Hypertension is prevalent in 35%-46% of the general population; 1% of them experience accelerated hypertension. Among patients with accelerated hypertension, acute worsening of renal functions occur in 22%-55%. Morbidity and mortality rates are high. Read More

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November 2020

Clinico-pathological Profile and Outcome of C-3 Glomerulopathy in Indian Children.

Indian J Nephrol 2020 Nov-Dec;30(6):370-376. Epub 2020 Feb 7.

Department of Pathology, Jaslok Hospital and Medical Research Institute, Mumbai, Maharashtra, India.

Introduction: There is paucity of data of C3 glomerulopathy in Indian children.

Methods: First Indian pediatric case series where consecutive renal biopsies done over a period of ten years were reviewed to identify those patients who had isolated or predominant C3 deposits on immunofluorescent microscopy, fulfilling the criteria for C-3 glomerulopathy. The clinical, biochemical, serological, histopathological profile, eGFR and the need for renal replacement therapy was analyzed. Read More

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February 2020

Early onset calciphylaxis following acute kidney injury secondary to anti-glomerular basement membrane antibody disease.

BMJ Case Rep 2021 Apr 7;14(4). Epub 2021 Apr 7.

Nephrology and Hypertension, Albany Medical Center Hospital, Albany, New York, USA.

Calciphylaxis is commonly associated with end-stage renal disease (ESRD) and renal transplant. We present a rare case of early onset calciphylaxis in a patient presenting with acute kidney injury (AKI) secondary to anti-glomerular basement membrane (anti-GBM) antibody disease. A 65-year-old obese Caucasian woman with type 2 diabetes mellitus and hypertension presented with a 1-month history of painless gross haematuria and worsening lower extremity oedema. Read More

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Atypical anti-glomerular basement membrane glomerulonephritis in a patient with metastatic melanoma treated with mitogen-activated protein kinase and immune checkpoint inhibitors: a case report.

J Med Case Rep 2021 Apr 3;15(1):186. Epub 2021 Apr 3.

Division of Nephrology, University of Massachusetts Medical School -Baystate, Springfield, MA, USA.

Background: Immune checkpoint inhibitors and mitogen-activated protein kinase inhibitors have become the standard of care in patients with advanced melanoma bearing V600 mutations. However, little is known about their nephrotoxicity. To date, only two cases of anti-glomerular basement membrane glomerulonephritis after exposure to checkpoint inhibitors have been documented. Read More

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IgA-Dominant Infection-Associated Glomerulonephritis Following SARS-CoV-2 Infection.

Viruses 2021 03 31;13(4). Epub 2021 Mar 31.

Nephrology Department, Hospital Clínico Universitario, INCLIVA, Universidad de Valencia, 46010 Valencia, Spain.

The renal involvement of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been reported. The etiology of kidney injury appears to be tubular, mainly due to the expression of angiotensin-converting enzyme 2, the key joint receptor for SARS-CoV-2; however, cases with glomerular implication have also been documented. The multifactorial origin of this renal involvement could include virus-mediated injury, cytokine storm, angiotensin II pathway activation, complement dysregulation, hyper-coagulation, and microangiopathy. Read More

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Renal Morphology in Coronavirus Disease: A Literature Review.

Medicina (Kaunas) 2021 Mar 11;57(3). Epub 2021 Mar 11.

Patology Department, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto 14049-900, SP, Brazil.

Renal biopsy is useful to better understand the histological pattern of a lesion (glomerular, tubulointerstitial, and vascular) and the pathogenesis that leads to kidney failure. The potential impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on the kidneys is still undetermined, and a variety of lesions are seen in the kidney tissue of coronavirus disease patients. This review is based on the morphological findings of patients described in case reports and a series of published cases. Read More

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A Rare and Severe Presentation of Henoch-Schönlein Purpura in an Adolescent With Crescentic Glomerulonephritis, Arrhythmia, Acute Gastrointestinal Bleed, and Neurological Complications.

Cureus 2021 Mar 29;13(3):e14169. Epub 2021 Mar 29.

Pathology, Norton Children's Hospital, Louisville, USA.

Henoch-Schönlein purpura (HSP) is a childhood vasculitis disorder that involves the skin, joints, gastrointestinal (GI) tract, and kidneys. It is related to immunoglobulin A (IgA) antibody deposition in small blood vessels. HSP is a self-limiting disorder, but its morbidity is primarily associated with renal involvement. Read More

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Relapse of treated anti-GBM disease following hair dye use.

BMJ Case Rep 2021 Apr 1;14(4). Epub 2021 Apr 1.

Department of Nephrology, NHS Dumfries and Galloway, Dumfries, UK

An 18-year-old woman was treated for acute kidney injury (AKI) secondary to antiglomerular basement membrane (GBM) disease with prednisolone, cyclophosphamide and plasma exchange. She also had epistaxis at initial presentation with no other organ involvement and achieved good recovery of her kidney function. Two weeks after completing induction treatment, she re-presented with further AKI and pulmonary haemorrhage. Read More

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ANCA-associated vasculitis overlaps with systemic sclerosis: a case report and literature review.

Eur J Med Res 2021 Mar 31;26(1):30. Epub 2021 Mar 31.

Department of Rheumatology and Immunology, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, No.32 The First Ring Road West 2, Chengdu, 610072, China.

Background: Systemic sclerosis (SSc) and anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) both affect the kidney and may cause renal failure. Treatment of AAV is dramatically different from that of SSc renal crisis (SRC). Kidney biopsy is not recommended for diagnosing SRC, but it is the only reliable diagnostic method for AAV. Read More

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The complex interplay between kidney injury and inflammation.

Clin Kidney J 2021 Mar 21;14(3):780-788. Epub 2020 Oct 21.

Department of Women and Children's Health, Institute of Translational Medicine, University of Liverpool, Liverpool, UK.

Acute kidney injury (AKI) has gained significant attention following patient safety alerts about the increased risk of harm to patients, including increased mortality and hospitalization. Common causes of AKI include hypovolaemia, nephrotoxic medications, ischaemia and acute glomerulonephritis, although in reality it may be undetermined or multifactorial. A period of inflammation either as a contributor to the kidney injury or resulting from the injury is almost universally seen. Read More

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