604,122 results match your criteria Globe Rupture


A Comparison of the Shielding Effectiveness of Silicone Oil Vitreous Substitutes when used with Palladium-103 and Iodine-125 Eye Plaques.

Med Phys 2018 Dec 16. Epub 2018 Dec 16.

200 Medical Plaza Ste B265, Los Angeles, CA, 90095.

Purpose: Epi-scleral eye plaques provide excellent local control of ocular melanoma, but vision sparing remains a significant problem with 30% or more of patients experiencing significant visual acuity degradation. The use of silicone oil shielding with Iodine-125 plaques has previously been reported to improve critical structure sparing. We hypothesized that the use of Palliadium-103 would improve the shielding effectiveness of silicone oil due to the strong energy dependence of the photoelectric effect. Read More

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December 2018

Subconjunctival draining minimally-invasive glaucoma devices for medically uncontrolled glaucoma.

Cochrane Database Syst Rev 2018 Dec 16;12:CD012742. Epub 2018 Dec 16.

Ophthalmology, Nottingham University Hospital, Derby Road, Nottingham, UK, NG7 2UH.

Background: Glaucoma is a leading cause of irreversible blindness. Subconjunctival draining minimally-invasive glaucoma devices such as the Xen gelatin implant and InnFocus stent have been introduced as a treatment to prevent glaucoma progressing.These implants provide a channel to allow aqueous humour from the anterior chamber of the eye to drain into the subconjunctival space on the surface of the eye thus reducing intraocular pressure (IOP) and mimicking the mechanism of the most commonly undertaken glaucoma surgery, trabeculectomy. Read More

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December 2018

Elevated levels of serum nitrite and nitrate, NOx, are associated with increased total and cardiovascular mortality in an 8-year follow-up study.

Eur J Clin Invest 2018 Dec 16:e13061. Epub 2018 Dec 16.

National Medical Research Center for Preventive Medicine of the Ministry of Healthcare of Russian Federation, 10 Petroverigsky per., Building 3, Moscow, 101990, Russia.

Background: Nitric oxide (NO) is one of the key regulators of vascular function. Abnormal NO signaling is linked to various cardiovascular diseases. We studied associations between circulating levels of nitric oxide metabolites, nitrite and nitrate (NOx), and total and cardiovascular mortality in a prospective 8-year follow-up cohort study in 1869 patients aged over 55 years. Read More

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December 2018

Effect of model race and viewing perspective on body attractiveness and body size assessment in young Caucasian women: an eye-tracking study.

Psychol Res 2018 Dec 15. Epub 2018 Dec 15.

School of Psychology, University of Lincoln, Brayford Pool, Lincoln, LN6 7TS, UK.

Research has indicated that Caucasian women gaze more often at waist-hip and chest regions than other local body areas when assessing female body attractiveness and body size, and this stereotypical gaze distribution is further modulated by their own body satisfaction and body composition. However, little is known whether the model race and viewing perspective could affect women's body-viewing gaze behaviour and body perception. Here, we presented female body images of Caucasian, Asian and African avatars in a continuum of common dress sizes in full frontal, mid-profile and rear view, and asked young Caucasian women to rate the perceived body attractiveness and body size. Read More

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December 2018

Association between REM sleep and obstructive sleep apnea in obese and overweight adolescents.

Sleep Breath 2018 Dec 15. Epub 2018 Dec 15.

Children's Hospital Los Angeles, 4650 Sunset Blvd., #83, Los Angeles, CA, USA.

Purpose: Overweight and obese children have demonstrated reduced rapid eye movement (REM) sleep, affecting energy balance regulation and predisposition to weight gain. Obstructive sleep apnea (OSA) is a known cause of decreased REM sleep. The purpose of this study is to examine the association between the percentage of REM sleep, BMI z-score, and OSA severity in overweight and obese adolescents. Read More

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December 2018

Increased choroidal thickness: a new feature to monitor age-related macular degeneration recurrence.

Graefes Arch Clin Exp Ophthalmol 2018 Dec 16. Epub 2018 Dec 16.

Hôpital d'Instruction des Armées Desgenettes, 108 Boulevard Pinel, 69003, Lyon, France.

Purpose: The main objective of this study was to assess choroidal thickness (CT) changes during an exudative recurrence of age-related macular degeneration (AMD).

Methods: A real-life prospective non-interventional 9-month study was conducted in two centers in consecutive patients with exudative AMD between November 2016 and July 2017. CT was measured manually in both eyes based on enhanced-depth imaging spectral-domain optical coherence tomography at different follow-up visits scheduled in the morning. Read More

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December 2018

Effects of posterior scleral reinforcement in pathological myopia: a 3-year follow-up study.

Graefes Arch Clin Exp Ophthalmol 2018 Dec 15. Epub 2018 Dec 15.

Department of Ophthalmology, the Fourth Affiliated Hospital of China Medical University, Eye Hospital of China Medical University, Key Laboratory of Lens Research of Liaoning Province, Shenyang, China.

Purpose: To assess the effects of posterior sclera reinforcement (PSR) in refractive outcomes, choroidal thickness (CT), and retinal thickness (RT) during a 3-year follow-up in eyes with pathological myopia.

Methods: Thirty-eight eyes of 26 adults with pathological myopia who underwent PSR (the PSR group) and 30 eyes of 18 adults with matched age and myopia who did not receive PSR treatment (the control group) were followed up with measurements of axial length (AL), spherical equivalent (SE), best corrected visual acuity (BCVA), CT, and RT at baseline, 1 and 3 months, and 1, 2, and 3 years postoperatively. Data were analyzed by repeated measures analysis of variance and independent-samples t test. Read More

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December 2018

Playing Super Mario increases oculomotor inhibition and frontal eye field grey matter in older adults.

Exp Brain Res 2018 Dec 15. Epub 2018 Dec 15.

Centre de Recherche en Neuropsychologie et Cogntion, University of Montreal, Pavillon Marie-Victorin 90, Avenue Vincent d'Indy, Montreal, QC, H2V 2S9, Canada.

Aging is associated with cognitive decline and decreased capacity to inhibit distracting information. Video game training holds promise to increase inhibitory mechanisms in older adults. In the current study, we tested the impact of 3D-platform video game training on performance in an antisaccade task and on related changes in grey matter within the frontal eye fields (FEFs) of older adults. Read More

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December 2018

Diagnostic Accuracy of Digital Retinal Fundus Image Analysis in Detecting Diabetic Maculopathy in Type 2 Diabetes Mellitus.

Ophthalmic Res 2018 Dec 14:1-7. Epub 2018 Dec 14.

School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Northern Ireland, Belfast, United Kingdom.

Background: Digital retinal imaging is the gold standard technique for diabetic retinopathy (DR) and diabetic macular oedema (DME) assessment during DR screening.

Objectives: To evaluate the diagnostic accuracy of digital retinal fundus image (DRFI) analysis in detecting DME using three manual grading systems (MGS) and comparing it with optical coherence tomography (OCT) findings.

Method: A total of 287 DRFI of 287 eyes were analysed. Read More

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December 2018

Risk factors for childhood violence and polyvictimization: A cross-country analysis from three regions.

Child Abuse Negl 2018 Dec 13;88:348-361. Epub 2018 Dec 13.

UNICEF Office of Research-Innocenti, Piazza SS Annunziata 12, 50121, Florence, Italy.

Understanding risk factors is important to ending childhood violence and meeting Sustainable Development Goal 16.2. To date, no study has examined patterns of risk factors across countries comprehensively for different types of childhood violence, and there is a dearth of evidence of polyvictimization in lower- and middle-income settings. Read More

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December 2018

In-situ forming gels containing fluorometholone-loaded polymeric nanoparticles for ocular inflammatory conditions.

Colloids Surf B Biointerfaces 2018 Nov 27;175:365-374. Epub 2018 Nov 27.

Department of Pharmacy, Pharmaceutical Technology and Physical Chemistry, Faculty of Pharmacy and Food Sciences, University of Barcelona, 08028, Barcelona, Spain; Institute of Nanoscience and Nanotechnology (IN2UB), University of Barcelona, Barcelona, Spain. Electronic address:

Thermosensitive gels have been developed and optimized in such a way that they become gels at corneal temperature and with a viscosity that allows the adequate release of the Fluorometholone (FMT)-loaded PLGA nanoparticles (NPs) in order to improve ocular anti-inflammatory efficacy against a commercial formulation. It has been shown that gels avoid burst release of the drug in the first hours with a slow and increasing profile after administration. NPs have maintained their average size and spherical shape within the gels as confirmed by transmission electron microscopy (TEM). Read More

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November 2018

A regression model including fetal orbit measurements to predict parturition in Standardbred mares with normal pregnancy.

Theriogenology 2018 Dec 10;126:153-158. Epub 2018 Dec 10.

Department of Veterinary Medical Sciences, University of Bologna, Via Tolara di Sopra 50, 40064, Ozzano Emilia, Bologna, Italy. Electronic address:

In the mare, foaling is a critical unpredictable event due to a wide range of gestational length and the absence of clear signs of impending parturition. To predict foaling, pH, inversion sodium potassium and increase of calcium concentration in mammary secretions are used. The aim of this study was to find how many days are left until parturition knowing mare's age (A) and parity (P) combined with ultrasonographic measurements of the fetal orbit in Standardbred mares with normal pregnancy. Read More

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December 2018

Using a deep learning algorithm and integrated gradients explanation to assist grading for diabetic retinopathy.

Ophthalmology 2018 Nov 28. Epub 2018 Nov 28.

Google Research, Google Inc, Mountain View, CA, USA.

Objective: To understand the impact of deep learning diabetic retinopathy (DR) algorithms on physician readers in computer-assisted settings.

Design: Evaluation of diagnostic technology PARTICIPANTS: 1,796 retinal fundus images from 1,612 diabetic patients.

Methods: 10 ophthalmologists (5 general ophthalmologists, 4 retina specialists, 1 retina fellow) read images for DR severity based on the International Clinical Diabetic Retinopathy disease severity scale in one of 3 conditions: Unassisted, Grades Only, or Grades + Heatmap. Read More

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November 2018

Corneal-PAMPA: A novel, non-cell-based assay for prediction of corneal drug permeability.

Eur J Pharm Sci 2018 Dec 13. Epub 2018 Dec 13.

Chemistry Department, Gedeon Richter Plc, Gyömrői út 19-21, 1107 Budapest, Hungary. Electronic address:

The present study was aimed to develop an in vitro non-cell-based method, for the measurement of corneal permeability. To this avail, the parallel artificial membrane permeability assay (PAMPA) was used for studying the effects of composition of the artificial lipid membrane, the DMSO cosolvent content of the donor phase as well as different buffer solutions in the model. Based on experimental corneal permeability values of 25 active pharmaceutical ingredients (APIs), a final model with good predictive ability (R = 0. Read More

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December 2018

National Study of Ocular Hospitalizations in Medicare Beneficiaries.

Am J Ophthalmol 2018 Dec 13. Epub 2018 Dec 13.

Department of Ophthalmology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois USA; Center for Healthcare Studies, Feinberg School of Medicine, Northwestern University, Chicago, Illinois USA; Veterans Affairs Health Services Research and Development Service, Chicago, Illinois USA. Electronic address:

Purpose: To study the characteristics of Medicare Beneficiaries hospitalized for ophthalmic conditions DESIGN: Cross-sectional study METHODS: The 2015 National Medicare 100% Inpatient Limited Dataset was analyzed to identify all patients with either an admitting or primary diagnoses for an ophthalmic condition using ICD-9-CM codes. All other hospitalized Medicare patients served for comparison. Comorbidities were calculated using the Elixhauser Comorbidity Index. Read More

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December 2018

Age-related changes in neural coding of envelope cues: peripheral declines and central compensation.

Neuroscience 2018 Dec 13. Epub 2018 Dec 13.

Department of Otolaryngology, Harvard Medical School, and Eaton-Peabody Laboratories, Massachusetts Eye and Ear Infirmary, Boston, MA, 02114, USA.

Aging listeners often experience difficulties in perceiving temporally complex acoustic cues in noisy environments. These difficulties likely have neurophysiological contributors from various levels of auditory processing. Cochlear synapses between inner hair cells and auditory nerve fibers exhibit a progressive decline with age which is not reflected in the threshold audiogram. Read More

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December 2018

Nasal respiration is necessary for the generation of γ oscillation in the olfactory bulb.

Neuroscience 2018 Dec 13. Epub 2018 Dec 13.

Biosensor National Special Laboratory, Key Laboratory for Biomedical Engineering of Education Ministry, Department of Biomedical Engineering, Zhejiang University, Hangzhou 310027, China. Electronic address:

γ oscillations (30-120 Hz) are generated intrinsically within local networks in the mammalian olfactory bulb (OB). The OB directly receives peripheral input from olfactory sensory neurons (OSNs) that can respond to nasal airflow, and centrifugal input from neuromodulatory systems whose activities are affected by the behavioral states of animal. How peripheral and centrifugal input dynamically modulate γ oscillations is unclear. Read More

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December 2018

Titanium ossicular chain reconstruction in single stage canal wall down tympanoplasty for chronic otitis media with mucosa defect.

Am J Otolaryngol 2018 Nov 28. Epub 2018 Nov 28.

Department of Otology and Skull Base Surgery, Eye and ENT Hospital, Fudan University, 83 Fenyang Road, Shanghai, China; NHC Key Laboratory of Hearing Medicine, Fudan University, Shanghai, China. Electronic address:

Purpose: To evaluate surgical outcomes for chronic otitis media with mucosa defect underwent titanium ossicular chain reconstruction (OCR) in single stage canal wall down tympanoplasty (CWD).

Methods: A clinical retrospective study was performed on 83 cases of the chronic otitis media with mucosa defect and 123 ears with mucosa integrity according to intraoperative findings that underwent synchronous titanium OCR in single stage CWD form January 2012 to January 2018. Pre- and postoperative air conduction threshold (AC), air-bone gap (ABG) and ABG closure at 0. Read More

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November 2018

Comparison of different PCR protocols and respective primer sets from pool of TAMS 1 gene for diagnosis of calf theileriosis from semi arid India.

Biologicals 2018 Dec 12. Epub 2018 Dec 12.

U P Pandit Deen Dayal Upadhyaya Pashu Chikitsa Vigyan Vishwavidyalaya Evam Go Anusandhan Sansthan (DUVASU), Mathura, 281001, India.

The polymorphic nature of Theileria annulata merozoite surface antigen (TAMS 1) attributes to limitation in PCR based detection of various T. annulata genotypes present in different geographical domains across the globe. Multiple reports of failure of detection of tropical theileriosis using classical N516/517 primer set in the studied area were noticed. Read More

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December 2018

Involuntary Eye Movements Accompanied by Head Thrusting to View Objects.

Pediatr Neurol 2018 Oct 23. Epub 2018 Oct 23.

Department of Pediatrics, Jichi Medical University, Shimotsuke, Japan.

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October 2018

Monocyte infiltration rather than microglia proliferation dominates the early immune response to rapid photoreceptor degeneration.

J Neuroinflammation 2018 Dec 15;15(1):344. Epub 2018 Dec 15.

Department of Cell Biology and Human Anatomy, University of California, Davis, 1 Shields Avenue, Davis, CA, 95616, USA.

Background: Activation of resident microglia accompanies every known form of neurodegeneration, but the involvement of peripheral monocytes that extravasate and rapidly transform into microglia-like macrophages within the central nervous system during degeneration is far less clear.

Methods: Using a combination of in vivo ocular imaging, flow cytometry, and immunohistochemistry, we investigated the response of infiltrating cells in a light-inducible mouse model of photoreceptor degeneration.

Results: Within 24 h, resident microglia became activated and began migrating to the site of degeneration. Read More

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December 2018

Protective effects of REM sleep without atonia against obstructive sleep apnea in patients with idiopathic REM sleep behavior disorder.

Sleep Med 2018 Nov 19;54:116-120. Epub 2018 Nov 19.

Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea. Electronic address:

Background: This study investigated the protective effect of rapid eye movement (REM) sleep without atonia against obstructive sleep apnea (OSA) in patients with idiopathic REM sleep behavior disorder (RBD).

Methods: In this case-control study, patients with idiopathic RBD and OSA (RBD-OSA) were consecutively enrolled and OSA controls without RBD were matched for age, sex, and apnea-hypopnea index (AHI). Clinical and polysomnographic characteristics were compared between RBD-OSA patients and OSA controls. Read More

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November 2018

Perceptual size discrimination requires awareness and late visual areas: A continuous flash suppression and interocular transfer study.

Conscious Cogn 2018 Dec 11;67:77-85. Epub 2018 Dec 11.

Department of Psychology and Counselling, School of Psychology and Public Health, La Trobe University, Melbourne, Victoria, Australia. Electronic address:

We applied continuous flash suppression (CFS) during an interocular transfer paradigm to evaluate the importance of awareness and the contribution of early versus late visual structures in size recognition. Specifically, we tested if size judgements of a visible target could be influenced by a congruent or incongruent prime presented to the same or different eye. Without CFS, participants categorised a target as "small" or "large" more quickly when it was preceded by a congruent prime - regardless of whether the prime and target were presented to the same or different eye. Read More

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December 2018

The therapeutic potential of curcumin: A review of clinical trials.

Eur J Med Chem 2018 Dec 7;163:527-545. Epub 2018 Dec 7.

Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran, 11369, Iran; Department of Chemistry, Richardson College for the Environmental Science Complex, The University of Winnipeg, Winnipeg, MB, R3B 2G3, Canada. Electronic address:

Curcuma longa L., its derived extracts and even its major compound curcumin has a long history of use and doubtless effectiveness, reported through increasingly detailed in vitro, ex vivo, in vivo and even clinical trials. Regarding its biological effects, multiple health-promoting, disease-preventing and even treatment attributes has been remarkably highlighted. Read More

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December 2018
5 Reads
3.447 Impact Factor

Dual 0.02% chlorhexidine digluconate - 0.1% disodium EDTA loaded thermosensitive ocular gel for Acanthamoeba keratitis treatment.

Int J Pharm 2018 Dec 12. Epub 2018 Dec 12.

Service Pharmaceutique, Plateforme Fripharm, Groupe Hospitalier Centre Edouard Herriot, Hospices Civils de Lyon, 5, Place d'Arsonval, F-69437 Lyon cedex 03, France; Université de Lyon, Laboratoire de Pharmacie Galénique Industrielle, UMR-CNRS 5305, Plateforme Fripharm, ISPB-Faculté de Pharmacie, Université Claude Bernard Lyon 1, 8, avenue Rockefeller, F-69373 Lyon Cedex 08, France. Electronic address: http://fripharm.com.

Poor bioavailability and low residence time limit the efficiency of conventional biguanide-based eye drops against Acanthamoeba keratitis. The aim of this work was to formulate an original anti-amoebic thermoreversible ocular gel combining biguanide and metalloproteases inhibitor - chelating agent. Chlorhexidine digluconate (CHX)-ethylenediaminetetraacetic acid disodium salt (NaEDTA) were compounded in poloxamer 407 saline solution. Read More

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December 2018

Clinical signs of meibomian gland dysfunction (MGD) are associated with changes in meibum sphingolipid composition.

Ocul Surf 2018 Dec 12. Epub 2018 Dec 12.

Department of Ophthalmology, Anatomy and Neurobiology, University of Tennessee Health Sciences Center, Hamilton Eye Institute, 930 Madison Avenue, Memphis, TN, 38163, USA. Electronic address:

Purpose: Sphingolipids (SPL) play roles in cell signaling, inflammation, and apoptosis. Changes in SPL composition have been reported in individuals with MGD, but associations between clinical signs of MGD and compositional changes in meibum SPLs have not been examined.

Methods: Forty-three individuals underwent a tear film assessment. Read More

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December 2018
1 Read

Human meibum chain branching variability with age, gender and meibomian gland dysfunction.

Ocul Surf 2018 Dec 12. Epub 2018 Dec 12.

Department of Ophthalmology and Visual Sciences, University of Louisville, Louisville, KY, 40202, USA.

NMR spectroscopy was used to measure hydrocarbon chain branching variability in meibum with age, gender and Meibomian gland dysfuction (MGD). A cohort of 65 meibum donors without dry eye and 31 donors with MGD was studied. Heteronuclear 2D NMR was used to confirm CH resonance assignments allowing us to positively identify 23 of the 27 proton resonances of cholesteryl ester and H resonances due to straight chain, iso-branched and anteiso-branched hydrocarbons. Read More

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December 2018
1 Read

Identification of a novel mutation in FBN1 in a Chinese family with inherited ectopia lentis by targeted NGS.

Gene 2018 Dec 12. Epub 2018 Dec 12.

Aier School of Ophthalmology, Central South University, Tianxin District, Changsha, Hunan Province 410015, China; WuhanAier Eye Hospital, Aier Eye Hospital Group, Wuchuan District, Wuhan, Hubei Province 430063, China. Electronic address:

Aims: To diagnose a Chinese family with inherited ectopia lentis in a genetic method and analyze the genotype-phenotype correlation.

Methods: The phenotype of each family member was identified by detailed clinical examination. We used targeted next generation sequencing (NGS) to identify mutations in FBN1 in an efficient and accurate way. Read More

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December 2018

Immune cells in the retina and choroid: Two different tissue environments that require different defenses and surveillance.

Prog Retin Eye Res 2018 Dec 12. Epub 2018 Dec 12.

Department of Anatomy and Developmental Biology, Monash Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.

In the eye immune defenses must take place in a plethora of differing microenvironments ranging from the corneal and conjunctival epithelia facing the external environment to the pigmented connective tissue of the uveal tract containing smooth muscle, blood vessels and peripheral nerves to the innermost and highly protected neural retina. The extravascular environment of the neural retina, like the brain parenchyma, is stringently controlled to maintain conditions required for neural transmission. The unique physiological nature of the neural retina can be attributed to the blood retinal barriers (BRB) of the retinal vasculature and the retinal pigment epithelium, which both tightly regulate the transport of small molecules and restrict passage of cells and macromolecules from the circulation into the retina in a similar fashion to the blood brain barrier (BBB). Read More

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December 2018

Protocol for evaluation of topical ophthalmic drug products in different compartments of fresh eye tissues in a rabbit model.

J Pharmacol Toxicol Methods 2018 Dec 12. Epub 2018 Dec 12.

Office of Translational Science, Office of Clinical Pharmacology, Division of Applied Regulatory Science, U.S. Food and Drug Administration, Center for Drug Evaluation and Research, White Oak Federal Research Center, 10903 New Hampshire Ave, Silver Spring, MD 20993, USA. Electronic address:

Topical ophthalmic drugs are the most commonly used dosage form to treat diseases of the anterior segment of the eye. Although this dosage form has the advantages of ease of application, small volume dose, and rapid action and is largely devoid of systemic adverse effects, the bioavailability is low due to pre-corneal anatomical barriers and the nature of the drug formulation itself. Some complex generic formulations (suspensions, ointments, gels) for topical ophthalmic products face impediments to rapid regulatory approval because of the complex nature of the formulations and difficulties in determining bioequivalence with the innovator product. Read More

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December 2018

Binocular Visual Function with Staged Implantation of Diffractive Multifocal Intraocular Lenses with Three Add Powers.

Am J Ophthalmol 2018 Dec 12. Epub 2018 Dec 12.

Department of Ophthalmology, Tokyo Dental Collage Suidobashi Hospital.

Purpose: To evaluate the binocular visual function and depth of focus after staged implantation of diffractive multifocal intraocular lenses (MIOLs) with three different add powers following cataract removal.

Design: Prospective comparative case series.

Methods: Setting: Institutional. Read More

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December 2018

Choroidal microvascular dropout in primary angle closure glaucoma.

Am J Ophthalmol 2018 Dec 12. Epub 2018 Dec 12.

University Eye Clinic Maastricht, University Medical Center, Maastricht, the Netherlands.

Purpose: To determine the prevalence and factors associated with the presence of choroidal microvascular dropout (CMvD) in primary angle-closure glaucoma (PACG) eyes compared to primary open-angle glaucoma (POAG) eyes.

Design: Cross-sectional study METHODS: Thirty-six POAG eyes (36 patients) and 28 PACG eyes (28 patients) underwent optical coherence tomography angiography (OCTA). Presence of CMvD was evaluated on choroidal OCTA slabs. Read More

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December 2018
1 Read

Tear Inflammatory Cytokines Analysis and Clinical Correlations in Diabetes and Non-diabetes with Dry Eye.

Am J Ophthalmol 2018 Dec 12. Epub 2018 Dec 12.

Department of Ophthalmology, Beijing Key Laboratory of Restoration of Damaged Ocular Nerve, Peking University Third Hospital, Beijing, 100191, China. Electronic address:

Purpose: To enhance the understanding of dry eye (DE) in diabetes by evaluating the ocular surface characteristics and the levels of tear inflammatory cytokines.

Design: Cross-sectional study.

Methods: Subjects were divided into four groups: 32 patients in diabetes with DE group; 24 patients in diabetes without DE group; 28 patients in non-diabetes with DE group and 29 volunteers in normal group. Read More

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December 2018

The Impact of Prefilled Syringes on Endophthalmitis following Intravitreal Injection of Ranibizumab.

Am J Ophthalmol 2018 Dec 12. Epub 2018 Dec 12.

Mid Atlantic Retina, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, PA. Electronic address:

Purpose: To compare the rates of infectious endophthalmitis following intravitreal injection of ranibizumab using prefilled syringes vs. conventional preparation.

Design: Multicenter, retrospective, cohort study METHODS: All eyes receiving intravitreal injection of 0. Read More

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December 2018

The structure and stability of the disulfide-linked γS-crystallin dimer provide insight into oxidation products associated with lens cataract formation.

J Mol Biol 2018 Dec 12. Epub 2018 Dec 12.

Research School of Chemistry, The Australian National University, Acton, ACT, 2601, Australia. Electronic address:

The reducing environment in the eye lens diminishes with age, leading to significant oxidative stress. Oxidation of lens crystallin proteins is the major contributor to their destabilization and deleterious aggregation that scatters visible light, obscures vision and ultimately leads to cataracts. However, the molecular basis for oxidation-induced aggregation is unknown. Read More

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December 2018
1 Read

The structure of mammalian β-mannosidase provides insight into β-mannosidosis and Nystagmus.

FEBS J 2018 Dec 15. Epub 2018 Dec 15.

Department of Biochemistry and Groupe de Recherche Axé sur la Structure des Protéines, McGill University, Montreal, QC, H3G 0B1, Canada.

β-mannosidase is a lysosomal enzyme from the glycosyl hydrolase family 2 that cleaves the single β(1-4)-linked mannose at the non-reducing end of N-glycosylated proteins, and plays an important role in the polysaccharide degradation pathway. Mutations in the MANBA gene, which encodes the β-mannosidase, can lead to the lysosomal storage disease β-mannosidosis, as well as nystagmus, an eye condition characterized by involuntary eye movements. Here, we present the first structures of a mammalian β-mannosidase in both the apo and mannose-bound forms. Read More

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December 2018
1 Read

Case series of hypotony maculopathy after CyPass insertion treated with intra-luminal suture occlusion.

Clin Exp Ophthalmol 2018 Dec 15. Epub 2018 Dec 15.

Glaucoma Service, Moorfields Eye Hospital, London EC1V 2PD, United Kingdom. UCL Institute of Ophthalmology, London, United Kingdom.

The CyPass Micro-Stent (Alcon, Fort Worth, USA) is a minimally invasive glaucoma surgical (MIGS) device, implanted into the supra-choroidal space. The CyPass was FDA approved in July 2016 and CE marked in Europe. It was withdrawn voluntarily by the manufacturer in August 2018. Read More

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December 2018

Progression of retinitis pigmentosa on multimodal imaging: the PREP-1 study.

Clin Exp Ophthalmol 2018 Dec 15. Epub 2018 Dec 15.

The Wilmer Eye Institute, Johns Hopkins University School of Medicine, USA.

Importance: It is important to establish reliable outcome measures to detect progression in retinitis pigmentosa (RP).

Background: To evaluate progression of RP using multimodal imaging, including spectral-domain optical coherence tomography (SD-OCT), fundus autofluorescence (FAF) and microperimetry (MP).

Design: Retrospective longitudinal study at a tertiary teaching hospital. Read More

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December 2018
1.953 Impact Factor

What Is Behind Cerebellar Vertigo and Dizziness?

Cerebellum 2018 Dec 14. Epub 2018 Dec 14.

Department of Neurology, Ludwig-Maximilians University, Marchioninistrasse 15, 81377, Munich, Germany.

The differential diagnosis of vertigo or dizziness as a result of cerebellar disorders can be difficult as many patients with a cerebellar pathology do not present with the full spectrum of cerebellar signs. The main goal of this study was to describe the typical clinical features of these patients with vertigo or dizziness of a cerebellar origin. We reviewed the medical records of 5400 patients with vertigo and dizziness from our tertiary outpatient clinic for vertigo and balance disorders. Read More

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December 2018

Exploring the genetic diversity of Tylodelphys (Diesing, 1850) metacercariae in the cranial and body cavities of Mexican freshwater fishes using nuclear and mitochondrial DNA sequences, with the description of a new species.

Parasitol Res 2018 Dec 14. Epub 2018 Dec 14.

Departamento de Zoología, Instituto de Biología, Universidad Nacional Autónoma de México, Ciudad Universitaria, Avenida Universidad 3000, 04510, Mexico, Distrito Federal, Mexico.

Members of the genus Tylodelphys Diesing, 1850 are endoparasites of fish-eating birds, particularly ciconiids, anhingids, and podicipedids across the globe. Metacercariae of Tylodelphys spp. were collected from the cranial and body cavities of freshwater fishes in central and northern Mexico; adults were recovered from the intestine of two species of freshwater diving birds of the family Podicipedidae, commonly known as grebes, in two locations of central Mexico. Read More

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December 2018

Effects of botulinum toxin type A on the treatment of dry eye disease and tear cytokines.

Graefes Arch Clin Exp Ophthalmol 2018 Dec 14. Epub 2018 Dec 14.

Department of Ophthalmology, Chung-Ang University Hospital, College of Medicine, Seoul, South Korea.

Purpose: To determine the effects of botulinum toxin type A (BTX-A) injection on dry eye signs, symptoms, and tear cytokine levels in patients with intractable dry eye disease (DED).

Methods: In this prospective study, patients with intractable DED were randomized to a BTX-A (group A) or control group (group B). Patients were injected with BTX-A or normal saline in the medial part of the upper and lower eyelids. Read More

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December 2018

[Glaucoma and nanophthalmos].

Ophthalmologe 2018 Dec 14. Epub 2018 Dec 14.

Zentrum für Augenheilkunde, Uniklinik Köln, Joseph-Stelzmann Str. 9, 50931, Köln, Deutschland.

The term nanophthalmos refers to a clinically small eye that appears morphologically normal. A nanophthalmos is characterized by hyperopia but can also be associated with various secondary pathologies, such as angle-closure glaucoma. In particular, the perioperative risks associated with a nanophthalmic eye necessitate examination of the anatomical characteristics, which can result from the disproportional size of intraocular tissues despite structural normality. Read More

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December 2018

1-year outcomes of the Xen45 glaucoma implant.

Eye (Lond) 2018 Dec 14. Epub 2018 Dec 14.

Ophthalmology Department, Yeovil Hospital, Yeovil, UK.

Objectives: To describe the 12-month outcomes of the Xen45 glaucoma stent.

Methods: Non-comparative retrospective study of all cases who underwent Xen glaucoma surgery in April 2017 or earlier and completed 12 months of follow-up. The primary outcome measures were intraocular pressure (IOP) reduction and number of glaucoma medications at 12 months postoperatively. Read More

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December 2018
1.897 Impact Factor

Comment on: Eponymous women in ophthalmology: syndromes with prominent eye manifestations named after female physicians.

Eye (Lond) 2018 Dec 14. Epub 2018 Dec 14.

Department of Ophthalmology, West Suffolk Hospital, Bury St Edmunds, UK.

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December 2018

On the role of eye contact in gaze cueing.

Sci Rep 2018 Dec 14;8(1):17842. Epub 2018 Dec 14.

Istituto Italiano di Tecnologia, Social Cognition in Human-Robot Interaction, via Enrico Melen 83, 16152, Genova, Italy.

Most experimental protocols examining joint attention with the gaze cueing paradigm are "observational" and "offline", thereby not involving social interaction. We examined whether within a naturalistic online interaction, real-time eye contact influences the gaze cueing effect (GCE). We embedded gaze cueing in an interactive protocol with the iCub humanoid robot. Read More

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December 2018
2 Reads

Repeatability and Reproducibility of Quantification of Superficial Peri-papillary Capillaries by four Different Optical Coherence Tomography Angiography Devices.

Sci Rep 2018 Dec 14;8(1):17866. Epub 2018 Dec 14.

Doheny Image Reading Center, Doheny Eye Institute, Los Angeles, CA, USA.

This study was performed to test the repeatability and reproducibility of measurements of peri-papillary capillaries from four optical coherence tomography angiography (OCTA) devices. 109 healthy eyes were imaged with four OCTA devices (Spectralis, Optovue, Triton and Cirrus). A 3 × 3 mm scan pattern centered on the disc was repeated twice by each device. Read More

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December 2018

Sleep selectively stabilizes contextual aspects of negative memories.

Sci Rep 2018 Dec 14;8(1):17861. Epub 2018 Dec 14.

Department of Psychiatry, Beth Israel Deaconess Medical Center, Boston, MA, USA.

Sleep and emotion are both powerful modulators of the long-term stability of episodic memories, but precisely how these factors interact remains unresolved. We assessed changes in item recognition, contextual memory, and affective tone for negative and neutral memories across a 12 h interval containing sleep or wakefulness in 71 human volunteers. Our data indicate a sleep-dependent stabilization of negative contextual memories, in a way not seen for neutral memories, item recognition, or across wakefulness. Read More

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December 2018
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Drug and disease signature integration identifies synergistic combinations in glioblastoma.

Nat Commun 2018 Dec 14;9(1):5315. Epub 2018 Dec 14.

Center for Therapeutic Innovation, Department of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine, 1120 NW 14th St, Miami, FL, 33136, USA.

Glioblastoma (GBM) is the most common primary adult brain tumor. Despite extensive efforts, the median survival for GBM patients is approximately 14 months. GBM therapy could benefit greatly from patient-specific targeted therapies that maximize treatment efficacy. Read More

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December 2018

Comprehensive Evaluation of User Interface for Ventilators Based on Respiratory Therapists' Performance, Workload, and User Experience.

Med Sci Monit 2018 Dec 15;24:9090-9101. Epub 2018 Dec 15.

Department of Medical Engineering, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (mainland).

BACKGROUND Poor ergonomic design of ventilators can result in human errors. In this study, we evaluated the ergonomics of ventilators through respiratory therapists' performance, workload, and user experience. MATERIAL AND METHODS Sixteen respiratory therapists were recruited to this usability study of 3 ventilators. Read More

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December 2018
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