420,841 results match your criteria Global Heart [Journal]


Porcine-Derived Biomaterials in Tissue Engineering and Reconstructive Surgery: Considerations and Alternatives in Muslim Patients.

J Tissue Eng Regen Med 2018 Dec 16. Epub 2018 Dec 16.

Department of Plastic Surgery, Hand Surgery and Burn Centre, Faculty of Medicine, RWTH University Hospital, Aachen, Germany.

During the last three decades, tissue engineering and reconstructive surgery have become standard therapeutic options in the world of medicine. Several biomaterials, either alone, or in combination with cultured cellular products, have been introduced to compensate for the scarcity of autologous donor tissue or to improve healing in a variety of surgical specialties e.g. Read More

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December 2018

Genomic sequence capture of haemosporidian parasites: Methods and prospects for enhanced study of host-parasite evolution.

Mol Ecol Resour 2018 Dec 16. Epub 2018 Dec 16.

Museum of Southwestern Biology and Department of Biology, MSC03 2020, 1 University of New Mexico, Albuquerque, New Mexico, 87131-0001, USA.

Avian malaria and related haemosporidians (Plasmodium, [Para]Haemoproteus, and Leucocytoozoon) represent an exciting multi-host, multi-parasite system in ecology and evolution. Global research in this field accelerated after 1) the publication in 2000 of PCR protocols to sequence a haemosporidian mitochondrial (mtDNA) barcode, and 2) the development in 2009 of an open-access database to document the geographic and host ranges of parasite mtDNA haplotypes. Isolating haemosporidian nuclear DNA from bird hosts, however, has been technically challenging, slowing the transition to genomic-scale sequencing techniques. Read More

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December 2018

Maternal anaemia and maternal, foetal and neonatal outcomes in a prospective cohort study in India and Pakistan.

BJOG 2018 Dec 16. Epub 2018 Dec 16.

Thomas Jefferson University, 130 S 9th St, Philadelphia, PA, 19107, USA.

Objective: To describe the association of maternal anaemia with maternal, foetal and neonatal outcomes.

Design: Prospective cohort study.

Setting: Rural India and Pakistan. Read More

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December 2018

Characteristics of dietary intake among adult patients in hospitals in a lower middle-income country in Southeast Asia.

Nutr Diet 2018 Dec 16. Epub 2018 Dec 16.

School of Exercise and Nutrition Sciences, Faculty of Health, Queensland University of Technology Australia, Kelvin Grove, Queensland, Australia.

Aim: Low-dietary intake is a common problem and cause of malnutrition during hospitalisation. This study aims to determine the current dietary intake and food sources of hospitalised adults in Ho Chi Minh City.

Methods: Participants were adult patients from six general public hospitals in a multi-site survey undertaken in 2016. Read More

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December 2018

House dust mite drives pro-inflammatory eicosanoid reprogramming and macrophage effector functions.

Allergy 2018 Dec 16. Epub 2018 Dec 16.

Center of Allergy and Environment (ZAUM), Technical University of Munich and Helmholtz Center Munich, member of the German Center for Lung Research, 80802, Munich, Germany.

Background: Eicosanoid lipid mediators play key roles in type 2 immune responses, e.g. in allergy and asthma. Read More

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December 2018

Debunking a myopic view of nature versus nurture.

Authors:
John L Hopper

Clin Exp Optom 2019 Jan;102(1):1-2

Centre for Epidemiology and Biostatistics, School of Population and Global Health, The University of Melbourne, Carlton, Victoria, Australia.

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January 2019

Cancer control planning: self-assessment for pre-planning, development, implementation and evaluation of national cancer control plans.

Cancer Causes Control 2018 Dec 15. Epub 2018 Dec 15.

National Cancer Institute, Rockville, MD, USA.

The development of cancer control plans as a clearly defined concept began in the U.S. in the early 1990s. Read More

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December 2018

Efficacy of allergen-blocker mechanical barrier gel on symptoms and quality of life in patients with allergic rhinitis.

Eur Arch Otorhinolaryngol 2018 Dec 15. Epub 2018 Dec 15.

Division of Pediatric Immunology and Allergy, Dokuz Eylul University, Izmir, Turkey.

Propose: Allergic rhinitis (AR) is a very common, chronic and global health problem. In the last two decades, the efficiency of barrier-enforcing measures in AR has been investigated. In this study, we aimed to evaluate the effect of allergen-blocker mechanical barrier gel (MBG) (AlerjiSTOP) treatment on symptoms and quality of life score (QoLS) in patients with seasonal and perennial allergic rhinitis. Read More

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December 2018
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Effects of biochar and dicyandiamide combination on nitrous oxide emissions from Camellia oleifera field soil.

Environ Sci Pollut Res Int 2018 Dec 15. Epub 2018 Dec 15.

Ministry of Education and Jiangxi Key Laboratory of Crop Physiology, Ecology and Genetic Breeding, Jiangxi Agricultural University, Nanchang, 330045, China.

Greenhouse gas emissions from agricultural soils contribute substantially to global atmospheric composition. Nitrous oxide (NO) is one important greenhouse gas induces global warming. Nitrification inhibitors (NI) or biochar can be effective soil NO emission mitigation strategies for agricultural soils. Read More

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December 2018

Family functioning, moods, and binge eating among urban adolescents.

J Behav Med 2018 Dec 15. Epub 2018 Dec 15.

School of Community and Global Health, Claremont Graduate University, 675 W. Foothill Blvd., Ste. 310, Claremont, CA, 91711, USA.

This study builds upon prior research on associations between moods, family functioning, and binge eating, using ecological momentary assessment to examine moderating effects of family functioning on associations between moods and binge eating. This study was conducted among a nonclinical sample of urban adolescents. Family functioning was assessed using five constructs adopted from the FACES-IV measure: 'family cohesion,' 'family flexibility' 'family communication,' 'family satisfaction,' and 'family balance. Read More

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December 2018

Translation of basic research in cognitive science to HIV-risk: a randomized controlled trial.

J Behav Med 2018 Dec 15. Epub 2018 Dec 15.

Department of Psychiatry and Behavioral Sciences, University of Washington, 1100 NE 45th Street, Suite 300, Box 354944, Seattle, WA, 98195-4944, USA.

Many people enrolled in drug diversion programs are not receiving evidence-based prevention for HIV or hepatitis. This study translated basic research from cognitive science to increase screening for infection and condom use in this population. A parallel three-condition randomized trial was conducted in a drug diversion sample (N = 358), comparing a memory practice condition with two active control conditions. Read More

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December 2018

Molecular and NLO Properties of Red Fluorescent Coumarins - DFT Computations Using Long-Range Separated and Conventional Functionals.

J Fluoresc 2018 Dec 15. Epub 2018 Dec 15.

Computational Chemistry Group, Department of Chemistry, Faculty of Science, University of Mauritius, Réduit, 80832, Mauritius.

Comparative study of nonlinear optical properties of red fluorescent coumarins was carried out with density functional theory based ab initio method using the popular global hybrid (GH) and range separated hybrid (RSH) functionals and correlated with the spectroscopic values. The GHs - M06 L, PBE1PBE, M06, BHHLYP, M062X and M06HF and RSHs - HISSbPBE, wB97, wB97X, HSEH1PBE, CAM-B3LYP and wB97XD in combination with the double zeta basis function 6-311 + G(d,p) were used. The computed polarizability (α), hyperpolarizability of the first order (β) and second order (γ) computed by the RSHs are closer to the spectroscopic values compared to GHs. Read More

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December 2018

PsAID12 Provisionally Endorsed at OMERACT 2018 as Core Outcome Measure to Assess Psoriatic Arthritis-specific Health-related Quality of Life in Clinical Trials.

J Rheumatol 2018 Dec 15. Epub 2018 Dec 15.

From the Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore; Department of Medicine, Duke University School of Medicine, Durham, North Carolina; Kezar Life Sciences, South San Francisco; Division of Immunology, Stanford University, Palo Alto, California; Rheumatology Research, Swedish Medical Center and University of Washington School of Medicine, Seattle, Washington; Global Patient Outcomes and Real World Evidence, Eli Lilly and Co., Indianapolis, Indiana; University of Pennsylvania, Philadelphia, Pennsylvania; Department of Dermatology, University of Utah, Salt Lake City, Utah, USA; Royal Prince Alfred Hospital Medical Centre, Sydney, Australia; Department of Rheumatology and Immunology, Singapore General Hospital, Singapore; Royal National Hospital for Rheumatic Diseases, Bath; Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK; Musculoskeletal Statistics Unit: The Parker Institute, Bispebjerg and Frederiksberg Hospital, Copenhagen; Department of Rheumatology, Odense University Hospital, Odense, Denmark; Sorbonne Université; Rheumatology Department, Pitié Salpêtrière Hospital, AP-HP, Paris, France; VU Medical Centre, Amsterdam, the Netherlands; Global Medical Affairs, Pfizer Inc., Montreal, Quebec; Clinical Epidemiology Program, Ottawa Hospital Research Institute; Division of Rheumatology, Department of Medicine, and School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa; Musculoskeletal Health and Outcomes Research, St. Michael's Hospital and Institute for Work and Health; Department of Occupational Science and Occupational Therapy, Rehabilitation Sciences Institute, Institute for Health Policy Management and Evaluation, University of Toronto; University of Toronto; Krembil Research Institute; Psoriatic Arthritis Program, University Health Network, Toronto, Ontario, Canada; Department of Rheumatology, St. Vincent's University Hospital and Conway Institute for Biomolecular Research, University College Dublin, Dublin, Ireland. AMO is a Jerome L. Greene Foundation Scholar and is supported in part by a research grant from the US National Institute of Arthritis and Musculoskeletal and Skin Diseases of the US National Institutes of Health under award number P30-AR070254 (Core B), a Rheumatology Research Foundation Scientist Development award, and a Staurulakis Family Discovery award. A.M. Orbai, MD, MHS, Division of Rheumatology, Johns Hopkins University School of Medicine; R. Holland, MB, ChB, Royal Prince Alfred Hospital Medical Centre; Y.Y. Leung, MD, PhD, Department of Rheumatology and Immunology, Singapore General Hospital; W. Tillett, BSc, MBChB, PhD, MRCP, Royal National Hospital for Rheumatic Diseases; N. Goel, MD, Patient Research Partner, Department of Medicine, Duke University School of Medicine, and Kezar Life Sciences; R. Christensen, BSc, MSc, PhD, Professor of Biostatistics and Clinical Epidemiology, and Musculoskeletal Statistics Unit: The Parker Institute, Bispebjerg and Frederiksberg Hospital, and Department of Rheumatology, Odense University Hospital; N. McHugh, MBChB, MD, FRCP, FRCPath, Royal National Hospital for Rheumatic Diseases; L. Gossec, MD, PhD, Sorbonne Université, and Rheumatology Department, Pitié Salpêtrière Hospital, AP-HP; M. de Wit, PhD, Patient Research Partner, VU Medical Centre; P. Højgaard, MD, The Parker Institute, Bispebjerg and Frederiksberg Hospital; L.C. Coates, MBChB, PhD, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford; P.J. Mease, MD, Rheumatology Research, Swedish Medical Center and University of Washington School of Medicine; J. Birt, PharmD, Global Patient Outcomes and Real World Evidence, and Eli Lilly and Co.; L. Fallon, PhD, Global Medical Affairs, Pfizer Inc.; O. FitzGerald, MD, FRCPI, FRCP(UK), Newman Clinical Research Professor, Department of Rheumatology, St. Vincent's University Hospital, and Conway Institute for Biomolecular Research, University College Dublin; A. Ogdie, MD, MSCE, University of Pennsylvania; B. Shea, PhD, Clinical Epidemiology Program, Ottawa Hospital Research Institute, and School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa; V. Strand, MD, Division of Immunology, Stanford University; K. Callis Duffin, MD, Department of Dermatology, University of Utah; P. Tugwell, Division of Rheumatology, Department of Medicine, and School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa, and Clinical Epidemiology Program, Ottawa Hospital Research Institute; D. Beaton, BScOT, PhD, Musculoskeletal Health and Outcomes Research, St. Michael's Hospital and Institute for Work and Health, and Department of Occupational Science and Occupational Therapy, Rehabilitation Sciences Institute, and the Institute for Health Policy Management and Evaluation, University of Toronto; D.D. Gladman, MD, FRCPC, Professor of Medicine, University of Toronto, and Senior Scientist, Krembil Research Institute, and Director, Psoriatic Arthritis Program, University Health Network. Address correspondence to Dr. A.M. Orbai, MD, MHS, Assistant Professor of Medicine, Rheumatology, Director Psoriatic Arthritis Program, Johns Hopkins University School of Medicine, Division of Rheumatology, 5200 Eastern Ave., MFL Center Tower Suite 4100, Baltimore, Maryland 21224, USA. E-mail: Accepted for publication November 6, 2018.

Objective: The Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA) and Outcome Measures in Rheumatology (OMERACT) psoriatic arthritis (PsA) working group is developing a Core Outcome Measurement Set for PsA clinical trials [randomized controlled trials (RCT) and longitudinal observational studies (LOS)] using the OMERACT Filter 2.1 instrument selection algorithm. Our objective was to assess the Psoriatic Arthritis Impact of Disease questionnaire (PsAID12) for the measurement of the core domain PsA-specific health-related quality of life (HRQOL). Read More

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December 2018
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Risk factors for childhood violence and polyvictimization: A cross-country analysis from three regions.

Child Abuse Negl 2018 Dec 13;88:348-361. Epub 2018 Dec 13.

UNICEF Office of Research-Innocenti, Piazza SS Annunziata 12, 50121, Florence, Italy.

Understanding risk factors is important to ending childhood violence and meeting Sustainable Development Goal 16.2. To date, no study has examined patterns of risk factors across countries comprehensively for different types of childhood violence, and there is a dearth of evidence of polyvictimization in lower- and middle-income settings. Read More

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December 2018

Meaning in life buffers the association between clinical anxiety and global maladjustment in participants with common mental disorders on sick leave.

Psychiatry Res 2018 Dec 6;271:548-553. Epub 2018 Dec 6.

Escuela de doctorado. Universidad Católica de Valencia, San Vicente Mártir, España; Catedra UMIVALE Innovación e investigación en patologías del trabajo, Valencia, España.

An important goal of mental health specialists is to improve the quality of life and the adaptation of people with common mental disorders on sick leave. Meaning in life is a protective factor for people adjusting to distress and negative events. This study explores the buffering role of meaning in life in the relationship between clinical anxiety or negative affect and maladjustment in participants with common mental disorders on sick leave. Read More

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December 2018

Iron-related nigral degeneration influences functional topology mediated by striatal dysfunction in Parkinson's disease.

Neurobiol Aging 2018 Nov 22;75:83-97. Epub 2018 Nov 22.

Department of Radiology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China. Electronic address:

In Parkinson's disease (PD), iron accumulation in the substantia nigra (SN) exacerbates oxidative stress and α-synuclein aggregation, leading to neuronal death. However, the influence of iron-related nigral degeneration on the subcortical function and global network configuration in PD remains unknown. Ninety PD patients and 38 normal controls underwent clinical assessments and multimodality magnetic resonance imaging scans. Read More

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November 2018

Characterization of CDOM in saline and freshwater lakes across China using spectroscopic analysis.

Water Res 2018 Dec 8;150:403-417. Epub 2018 Dec 8.

Northeast Institute of Geography and Agroecology, CAS, Changchun 130102, China; University of Chinese Academy of Sciences, Beijing 100049, China. Electronic address:

Colored dissolved organic matter (CDOM) is a major component of DOM in waters, and plays a vital role in carbon cycling in inland waters. In this study, the light absorption and three-dimensional excitation-emission matrix spectra (EEMs) of CDOM of 936 water samples collected in 2014-2017 from 234 lakes in five regions across China were examined to determine relationships between lake water sources (fresh versus saline) and their fluorescence/absorption characteristics. Results indicated significant differences regarding DOC concentration and a(254) between freshwater (6. Read More

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December 2018

Gender-specific prevalence of poor sleep quality and related factors in a Chinese rural population: the Henan Rural Cohort Study.

Sleep Med 2018 Nov 22;54:134-141. Epub 2018 Nov 22.

Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, PR China. Electronic address:

Objective: To estimate the prevalence of poor sleep quality and identify related factors by gender in the Chinese rural population.

Methods: Overall, 27424 subjects (10881 males and 16543 females) aged 18-79 years were enrolled from the Henan Rural Cohort Study. Sleep quality was evaluated by the standard Pittsburgh Sleep Quality Index (PSQI) and global score>5 was classified as poor sleep quality. Read More

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November 2018

Hydrothermal pretreatment of source separated organics for enhanced solubilization and biomethane recovery.

Bioresour Technol 2018 Dec 10;274:502-511. Epub 2018 Dec 10.

Environmental Research Group for Resource Recovery, Department of Civil Engineering, Faculty of Engineering, Architecture and Science, Ryerson University, 350 Victoria Street, Toronto, Ontario M5B 2K3, Canada. Electronic address:

The objective of this research was to evaluate the effect of the hydrothermal pretreatment on the solubilization of source separated organics (SSO) as well as the biomethane recovery through the mesophilic batch anaerobic digestion process. For this purpose, the SSO was subjected to fifteen different pretreatment conditions within five different severity index (SI) values (3, 3.5, 4, 4. Read More

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December 2018

Production of biofuels and chemicals from xylose using native and engineered yeast strains.

Biotechnol Adv 2018 Dec 13. Epub 2018 Dec 13.

Department of Agricultural Biotechnology and Center for Food and Bioconvergence, Seoul National University, Seoul 08826, South Korea. Electronic address:

Numerous metabolic engineering strategies have allowed yeasts to efficiently assimilate xylose, the second most abundant sugar component of lignocellulosic biomass. During the investigation of xylose utilization by yeasts, a global rewiring of metabolic networks upon xylose cultivation has been captured, as opposed to a pattern of glucose repression. A clear understanding of the xylose-induced metabolic reprogramming in yeast would shed light on the optimization of yeast-based bioprocesses to produce biofuels and chemicals using xylose. Read More

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December 2018

Endoplasmic reticulum stress triggered by Soyasapogenol B promotes apoptosis and autophagy in colorectal cancer.

Life Sci 2018 Dec 13. Epub 2018 Dec 13.

The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China. Electronic address:

Aim: Colorectal cancer (CRC) is a common human malignancy which accounts for 600,000 deaths annually at the global level. Soyasapogenol B (Soy B), an ingredient of soybean, has been found to exert anti-proliferative activities in vitro in human breast cancer cells. The current study aimed to evaluate the efficacy of Soy B in suppressing CRC. Read More

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December 2018

Mortality, morbidity, and hospitalisations due to influenza lower respiratory tract infections, 2017: an analysis for the Global Burden of Disease Study 2017.

Authors:

Lancet Respir Med 2018 Dec 12. Epub 2018 Dec 12.

Background: Although the burden of influenza is often discussed in the context of historical pandemics and the threat of future pandemics, every year a substantial burden of lower respiratory tract infections (LRTIs) and other respiratory conditions (like chronic obstructive pulmonary disease) are attributable to seasonal influenza. The Global Burden of Disease Study (GBD) 2017 is a systematic scientific effort to quantify the health loss associated with a comprehensive set of diseases and disabilities. In this Article, we focus on LRTIs that can be attributed to influenza. Read More

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December 2018

Reconciling estimates of the global influenza burden.

Lancet Respir Med 2018 Dec 12. Epub 2018 Dec 12.

WHO Collaborating Centre for Infectious Disease Epidemiology and Control, School of Public Health, University of Hong Kong, Hong Kong Special Administrative Region, China.

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December 2018

Ganglioside synthase knock-out reduces prion disease incubation time in mouse models.

Am J Pathol 2018 Dec 13. Epub 2018 Dec 13.

Department of Laboratory Animal Medicine, Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai 980-8575, Japan.

Localization of the abnormal and normal isoforms of prion proteins to detergent-resistant membrane microdomains, lipid rafts, is important for the conformational conversion. Lipid rafts are enriched in sialic acid-containing glycosphingolipids, namely gangliosides. Alteration in the ganglioside composition of lipid rafts can affect the localization of lipid raft-associated proteins. Read More

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December 2018

Dynamin-1-like protein inhibition drives megamitochondria formation as an adaptive response in alcohol-induced hepatotoxicity.

Am J Pathol 2018 Dec 13. Epub 2018 Dec 13.

Institute of Hepatology London, Foundation for Liver Research, London, United Kingdom; King's College London, Faculty of Life Sciences and Medicine, London, United Kingdom. Electronic address:

Despite the growing global burden of alcoholic liver diseases, therapeutic options are limited and novel targets are urgently needed. Accumulating evidence suggests that mitochondria adapt in response to ethanol and formation of megamitochondria in the livers of patients is recognized as a hallmark of alcoholic liver diseases. The processes involved in ethanol-induced hepatic mitochondrial changes, the impact on mitochondria-shaping proteins, and the significance of megamitochondria formation remain unknown. Read More

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December 2018

Transcatheter aortic valve replacement outcomes in Japan: Optimized CathEter vAlvular iNtervention (OCEAN) Japanese multicenter registry.

Cardiovasc Revasc Med 2018 Dec 4. Epub 2018 Dec 4.

Department of cardiology, Keio University School of Medicine, Tokyo, Japan.

Objectives: We aimed to assess real-world clinical outcomes of transcatheter aortic valve replacement (TAVR) in Japan.

Background: Data are limited concerning procedural safety and valve performance following TAVR in Japanese. A program by an on-site proctor and procedure screening system was applied during TAVR introduction. Read More

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December 2018

Bi-directional drug-microbiome interactions of anti-diabetics.

EBioMedicine 2018 Dec 12. Epub 2018 Dec 12.

Department of Internal Medicine- Molecular Medicine, Department of Microbiology and Immunology, Wake Forest School of Medicine, Winston-Salem, NC, USA. Electronic address:

Type 2 diabetes (T2D) has become a global epidemic. Although several drugs are available to manage T2D, problems associated with person-to-person variability in drug efficacy and potential side-effects remain unresolved. Owing to the emerging role of the gut microbiome in obesity and T2D, the interaction between gut microbes and anti-diabetic drugs and its influence on drugs' functions remains of immediate research interest. Read More

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December 2018

The efficacy, effectiveness, and immunogenicity of influenza vaccines in Africa: a systematic review.

Lancet Infect Dis 2018 Dec 12. Epub 2018 Dec 12.

Vaccines and Immunity Theme, Medical Research Council Unit The Gambia at the London School of Hygiene & Tropical Medicine, Banjul, The Gambia; Centre of International Child Health, Section of Paediatrics, Department of Medicine, Imperial College London, St Mary's Campus, London, UK. Electronic address:

The burden of influenza in Africa is substantial and underappreciated. Although surveillance has increased, the medical community's understanding of seasonal influenza vaccine performance remains limited. We did a systematic review, using PRISMA guidelines (PROSPERO CRD42017058107), on the efficacy, effectiveness, and immunogenicity of influenza vaccines in populations within Africa with the aim of identifying key data gaps to help direct future research. Read More

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December 2018

Early Single-Site Experience With Transcatheter Tricuspid Valve Replacement.

JACC Cardiovasc Imaging 2018 Dec 6. Epub 2018 Dec 6.

Columbia University Medical Center/NewYork Presbyterian Hospital, New York, New York.

Objectives: This study presents a single-site experience of 5 patients with severe tricuspid regurgitation (TR) who underwent implantation of a novel transcatheter tricuspid valve replacement device.

Background: Functional TR is the most common etiology of severe TR in the developed world and is associated with unfavorable clinical outcomes. Although numerous transcatheter repair devices are currently in early clinical trials, most result in incomplete degrees of TR reduction and functional improvement. Read More

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December 2018

Sensory trick efficacy in cervical dystonia is linked to processing of neck proprioception.

Parkinsonism Relat Disord 2018 Dec 5. Epub 2018 Dec 5.

Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, Queen Square, London, UK.

Background: Muscle vibration activates muscle spindles and when applied over posterior neck muscles during stance modulates global body orientation. This is characterised by a tonic forward sway response that is reportedly diminished or absent in patients with idiopathic cervical dystonia.

Objective: To investigating the impact of the sensory trick on vibration-induced postural responses. Read More

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December 2018

Compound Genomic Alterations of TP53, PTEN, and RB1 Tumor Suppressors in Localized and Metastatic Prostate Cancer.

Eur Urol 2018 Dec 12. Epub 2018 Dec 12.

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA. Electronic address:

Background: TP53, PTEN, and RB1 tumor suppressor genes (TSGs) are recurrently altered in treatment-resistant prostate cancer. Cooperative loss of two or more TSGs may drive more aggressive disease.

Objective: To determine clinical outcomes of single and compound TSG alterations across the spectrum of prostate cancer. Read More

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December 2018

Interlaboratory comparison about feasibility of insoluble particulate matter test for injections with reduced test volume in light obscuration method.

Biologicals 2018 Dec 12. Epub 2018 Dec 12.

Division of Biological Chemistry and Biologicals, National Institute of Health Sciences, Tonomachi 3-25-26, Kawasaki-ku, Kanagawa, 210-9501, Japan.

Insoluble particulate matter test for injections in pharmacopoeia is mandatory for parenteral drug products. In this test using light obscuration, four measurements of at least 5-mL are required. Since therapeutic protein injections of low dosage volumes are getting more popular, reduction of test volumes is desired. Read More

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December 2018

A Pilot Study of Soluble Form of LOX-1 as a Novel Biomarker for Neonatal Hypoxic-Ischemic Encephalopathy.

J Pediatr 2018 Dec 11. Epub 2018 Dec 11.

Department of Mental Retardation and Birth Defect Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan. Electronic address:

Objective: To evaluate the soluble form of lectin-like oxidized low-density lipoprotein receptor-1 (sLOX-1) as a biomarker of severity staging and prognosis in neonatal hypoxic-ischemic encephalopathy (HIE).

Study Design: We performed an observational study enrolling 27 infants with HIE and 45 control infants of gestational age ≥36 weeks and birth weight ≥1800 g. The HIE criteria were pH ≤7. Read More

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December 2018

World leaders adopt first global pact on migration.

Authors:
Jocalyn Clark

Lancet 2018 Dec 12. Epub 2018 Dec 12.

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December 2018

Opening the toolkit for genetic analysis and control of Anopheles mosquito vectors.

Curr Opin Insect Sci 2018 Dec 26;30:8-18. Epub 2018 Jul 26.

Vector Biology Department, Liverpool School of Tropical Medicine, Liverpool, L3 5QA, UK.

Anopheles is the only genus of mosquitoes that transmit human malaria and consequently the focus of large scale genome and transcriptome-wide association studies. Genetic tools to define the function of the candidate genes arising from these analyses are vital. Moreover, genome editing offers the potential to modify Anopheles population structure at local and global scale to provide complementary tools towards the ultimate goal of malaria elimination. Read More

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December 2018

Development of co-continuous morphology in blends of thermoplastic starch and low-density polyethylene.

Carbohydr Polym 2019 Feb 13;206:757-766. Epub 2018 Nov 13.

Department of Chemical and Biotechnological Engineering, Université de Sherbrooke, 2500 boulevard de l'Université, Sherbrooke, QC, Canada. Electronic address:

This study focuses on the morphology development in blends of thermoplastic starch (TPS) with Low Density Polyethylene (LDPE) in the 40 to 80 TPS wt% concentration range. The effect of glycerol and water content on TPS rheology and the subsequent morphology development after blending with LDPE of various viscosity levels was investigated. The TPS/LDPE viscosity ratio was modified either by increasing the TPS plasticization or by proper selection of the LDPE grade. Read More

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February 2019

LED 209 conjugated chitosan as a selective antimicrobial and potential anti-adhesion material.

Carbohydr Polym 2019 Feb 17;206:653-663. Epub 2018 Nov 17.

Biomedical Engineering Institute, Jinan University, Guangzhou 510632, PR China. Electronic address:

The rapid emergence of antibiotic-resistant Gram-negative bacteria (GNB) is becoming a global healthcare concern, and it urgently needs novel strategies to match the clinical challenge. In this work, we conjugated chitosan (CS) with LED 209, a highly selective inhibitor of QseC of GNB, to create the novel selective antimicrobial agent CS/LED. The data of FT-IR, NMR and elemental analysis for CS/LED conjugates proved the successful conjugation of CS with LED 209. Read More

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February 2019

Hereditary cardiac amyloidosis associated with Pro24Ser transthyretin mutation: a case report.

J Med Case Rep 2018 Dec 16;12(1):370. Epub 2018 Dec 16.

Department of Clinical Research, Chiba Tokushukai Hospital, Chiba, Japan.

Background: Transthyretin amyloidosis is a systemic disorder caused by extracellular deposition of insoluble amyloid fibrils in peripheral and autonomic nerves, heart, kidney, gastrointestinal tract, and other organs. Hereditary transthyretin amyloidosis is an autosomal dominant disease. More than 120 mutations have been reported in the transthyretin gene with considerable phenotypic heterogeneity and geographic diversity. Read More

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December 2018

Granularity impact on hotspot formation and local chemistry in shocked nanostructured RDX.

Authors:
X Bidault N Pineau

J Chem Phys 2018 Dec;149(22):224703

CEA/DAM/DIF, F-91297 Arpajon, France.

The nanostructuration of energetic materials results in interesting properties. In particular, the detonation of carbon-rich explosives leads to the formation of nanodiamonds, the size of which is linked to the initial size of the explosive nanograins. This correlation could come from the role played by the granularity in the shock properties, especially the local temperature, which could be enhanced when the shock front crosses the various interfaces and nanoporosities of the material. Read More

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December 2018

An Accurate Automated Local Similarity Factor-Based Neural Tree Approach toward Tissue Segmentation of Newborn Brain MRI.

Am J Perinatol 2018 Dec 15. Epub 2018 Dec 15.

Shri Sant Gajanan Maharaj College of Engineering, Shegaon, Maharashtra, India.

Background:  Segmentation of brain MR images of neonates is a primary step for assessment of brain evolvement. Advanced segmentation techniques used for adult brain MRI are not companionable for neonates, due to extensive dissimilarities in tissue properties and head structure. Existing segmentation methods for neonates utilizes brain atlases or requires manual elucidation, which results into improper and atlas dependent segmentation. Read More

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December 2018
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Take-home naloxone is a global issue, in practice and in research: A response to Heavey et al.

Int J Drug Policy 2018 Dec 12;63:111-112. Epub 2018 Dec 12.

MRC Biostatistics Unit, Cambridge, UK.

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December 2018
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The impact of hydroelectric dams on mercury dynamics in South America: A review.

Chemosphere 2018 Dec 6;219:546-556. Epub 2018 Dec 6.

Programa de Pós-Graduação Em Ecologia e Recursos Naturais, Laboratório de Ciências Ambientais, Centro de Biociências e Biotecnologia, Universidade Estadual Do Norte Fluminense Darcy Ribeiro, Av. Alberto Lamego, 2000 - Parque Califórnia, CEP: 28013-602, Campos Dos Goytacazes, Rio de Janeiro, Brazil.

The increase in global demand for electric energy is reflected in plans to construct numerous hydroelectric dams in South America that can cause chronic ecological impacts if not built and managed correctly. One of the main impacts generated by hydropower dams is the accumulation of Hg chemical species in their reservoir compartments and the downstream transport of these contaminants. Hg circulation in these environments has been studied for 27 years and this review brings a synthesis of the dynamics that are now well established, so that future studies can focus on gaps and inconsistent results in the literature. Read More

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December 2018
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Strength limits in mesoscaled 3Y-TZP ceramics for micro-surgical instruments.

J Mech Behav Biomed Mater 2018 Dec 4;91:99-108. Epub 2018 Dec 4.

Department of Materials Science and Engineering, The Pennsylvania State University, University Park, PA 16802, USA; Institut fuer Struktur- und Funktionskeramik, Montanuniversitaet Leoben, Leoben 8700, Austria. Electronic address:

Micro-surgical instruments are a new application for mesoscale ceramics formed using the lost mold-rapid infiltration forming (LM-RIF) process. Instrument strength and reliability are the foremost concerns for this sensitive application. It is hypothesized that increasing grain size can improve the damage tolerance of the parts associated with the transformation toughening in the 3Y-TZP material, while retaining high strength. Read More

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December 2018

One-carbon metabolism nutrient intake and the association between body mass index and urinary arsenic metabolites in adults in the Chihuahua cohort.

Environ Int 2018 Dec 12;123:292-300. Epub 2018 Dec 12.

Environmental Science and Engineering, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; Curriculum in Toxicology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. Electronic address:

Background: Exposure to inorganic arsenic (iAs) via drinking water is a serious global health threat. Various factors influence susceptibility to iAs-associated health outcomes, including differences in iAs metabolism. Previous studies have shown that obesity is associated with iAs metabolism. Read More

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December 2018
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Home monitoring with IT-supported specialist management versus home monitoring alone in patients with heart failure: Design and baseline results of the SUPPORT-HF 2 randomized trial.

Authors:

Am Heart J 2018 Sep 25;208:55-64. Epub 2018 Sep 25.

The George Institute for Global Health, University of Oxford, 1st Floor, Hayes House, 75 George St, Oxford, United Kingdom.

Objectives: SUPPORT-HF 2 tests the hypothesis that home monitoring with information technology-supported specialist management is more effective in optimizing medical therapy than is home monitoring alone for patients with heart failure.

Methods And Results: The study was designed as a 2-armed partially blinded parallel randomized controlled trial. Seven sites in the United Kingdom (UK) recruited a total of 202 adults with heart failure at high risk of adverse outcomes and with potential to benefit from remote management (mean age 73 years, 28% female, median left ventricular ejection fraction 37%). Read More

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September 2018
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'There is no point giving cash to women who don't spend it the way they are told to spend it' - Exploring women's agency over cash in a combined participatory women's groups and cash transfer programme to improve low birthweight in rural Nepal.

Soc Sci Med 2018 Dec 6;221:9-18. Epub 2018 Dec 6.

Institute for Global Health, University College London, 30 Guilford Street, WC1N 1EH, United Kingdom. Electronic address:

Cash transfer programmes form an integral part of nutrition, health, and social protection policies worldwide, but the mechanisms through which they achieve their health and nutritional impacts are incompletely understood. We present results from a process evaluation of a combined participatory women's groups and cash transfer programme to improve low birth weight in rural Nepal. We explored the ways in which context, implementation, and mechanism of the intervention affected beneficiary women's agency over cash transfers. Read More

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December 2018
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Cortisol stress reactivity moderates the effects of parental corporal punishment on Chinese preschoolers' executive function.

Child Abuse Negl 2018 Dec 12;88:288-297. Epub 2018 Dec 12.

Research Center for Child Development, College of Elementary Education, Capital Normal University, No.105 Xisan Huan Beilu, Beijing, 100048, China. Electronic address:

Background: To date whether the effects of parental corporal punishment (CP) on executive function (EF) distinct components are different is less clear. Moreover, theory and empirical work suggest that physiological regulation system may help to explain the individual differences in the developmental outcomes associated with parental CP.

Objective: This study examined the effects of parental CP on Chinese preschoolers' EF and whether the cortisol stress reactivity would moderate such effects. Read More

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December 2018

Nanocrystalline solid dispersions (NSD) of hesperetin (HRN) for prevention of 7, 12-dimethylbenz[a]anthracene (DMBA)-induced breast cancer in Sprague-Dawley (SD) rats.

Eur J Pharm Sci 2018 Dec 12. Epub 2018 Dec 12.

Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research (NIPER), S.A.S. Nagar, Mohali, Punjab 160 062, India. Electronic address:

Breast cancer is the most commonly diagnosed cancer and the leading cause of cancer death in females as per the global cancer project (GLOBOCAN 2018) estimates of breast cancer incidence and mortality produced by the International Agency for Research on Cancer (IARC). In 2018, there will be 2,088,849 new cases of breast cancer and 626,679 cases of deaths due to breast cancer in 5 regions (Americas, Africa, Europe, Asia and Oceania) at 20 sites of the world. Epidemiologic studies on diet and cancer have guided the search for some nutraceuticals acting as anti-cancer agents. Read More

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December 2018

Physical exercise enhances adult cortical plasticity in a neonatal rat model of hypoxic-ischemic injury: Evidence from BOLD-fMRI and electrophysiological recordings.

Neuroimage 2018 Dec 12. Epub 2018 Dec 12.

Department of Health Sciences and Technology, SAIHST, Sungkyunkwan University, Seoul, 06351, South Korea; Department of Radiology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, 06351, South Korea; Center for Neuroscience Imaging Research, Institute for Basic Science (IBS), Suwon, South Korea; Animal Research and Molecular Imaging, Samsung Biomedical Research Institute, Samsung Medical Center, Seoul, 06351, South Korea; Department of Global Biomedical Engineering, Sungkyunkwan University, Suwon, Republic of Korea. Electronic address:

Neuroplasticity is considered essential for recovery from brain injury in developing brains. Recent studies indicate that it is especially effective during early postnatal development and during the critical period. The current study used functional magnetic resonance imaging (fMRI) and local field potential (LFP) electrophysiological recordings in rats that experienced neonatal hypoxic-ischemic (HI) injury during the critical period to demonstrate that physical exercise (PE) can improve cortical plasticity even when performed during adulthood, after the critical period. Read More

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December 2018

Electrophysiological and behavioral measures of some speech contrasts in varied attention and noise.

Hear Res 2018 Dec 6;373:1-9. Epub 2018 Dec 6.

Lund University Department of Psychology, Paradisgatan 5, Lund, 22100, Sweden. Electronic address:

This paper investigates the salience of speech contrasts in noise, in relation to how listening attention affects scalp-recorded cortical responses. The contrasts that were examined with consonant-vowel syllables, were place of articulation, vowel length and voice-onset time (VOT) and our analysis focuses on the correspondence between the effect of attention on the electrophysiology and the decrement in behavioral results when noise was added to the stimuli. Normal-hearing subjects (n = 20) performed closed-set syllable identification in no noise, 0, 4 and 8 dB signal-noise ratio (SNR). Read More

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December 2018