36,615 results match your criteria Glioblastoma Multiforme


Development of a Cx46 Targeting Strategy for Cancer Stem Cells.

Cell Rep 2019 Apr;27(4):1062-1072.e5

Department of Cellular and Molecular Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA; Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH 44195, USA; Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH 44106, USA. Electronic address:

Gap-junction-mediated cell-cell communication enables tumor cells to synchronize complex processes. We previously found that glioblastoma cancer stem cells (CSCs) express higher levels of the gap junction protein Cx46 compared to non-stem tumor cells (non-CSCs) and that this was necessary and sufficient for CSC maintenance. To understand the mechanism underlying this requirement, we use point mutants to disrupt specific functions of Cx46 and find that Cx46-mediated gap-junction coupling is critical for CSCs. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22111247193041
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http://dx.doi.org/10.1016/j.celrep.2019.03.079DOI Listing
April 2019
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MicroRNA‑576‑3p inhibits the migration and proangiogenic abilities of hypoxia‑treated glioma cells through hypoxia‑inducible factor‑1α.

Int J Mol Med 2019 Jun 4;43(6):2387-2397. Epub 2019 Apr 4.

Department of Neurosurgery, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, P.R. China.

The most common and aggressive type of brain cancer in adults is glioblastoma multiforme (GBM), and hypoxia is a common feature of glioblastoma. As the histological features of glioma include capillary endothelial cell proliferation, they are highly prone to invading the surrounding normal brain tissue, which is often one of the reasons for the failure of treatment. However, the mechanisms involved in this process are not fully understood. Read More

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http://dx.doi.org/10.3892/ijmm.2019.4157DOI Listing

Antiproliferative activity of essential oils from three plants of the Brazilian Cerrado: Campomanesia adamantium (Myrtaceae), Protium ovatum (Burseraceae) and Cardiopetalum calophyllum (Annonaceae).

Braz J Biol 2019 Apr 18. Epub 2019 Apr 18.

Instituto Federal de Educação, Ciência e Tecnologia do Triângulo Mineiro - Campus Uberlândia Centro, Rua Blanche Galassi, Morada da Colina, CEP 38411-104, Uberlândia, MG, Brasil.

Essential oils, which may be extracted from several parts of plants, have different biological activities. The Brazilian Cerrado has a large variety of plants that yield essential oils, even though many have not been studied yet. Taking into account the biodiversity of this biome, this study aimed at evaluating the antiproliferative activity of essential oils extracted from three species of plants of the Cerrado in Goiás state: Campomanesia adamantium (Cambess. Read More

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http://dx.doi.org/10.1590/1519-6984.192643DOI Listing

A five-CpG signature of microRNA methylation in non-G-CIMP glioblastoma.

CNS Neurosci Ther 2019 Apr 23. Epub 2019 Apr 23.

Department of Neurosurgery, Xijing Institute of Clinical Neuroscience, Xijing Hospital, Air Force Medical University, Xi'an, China.

Aims: DNA methylation has been found to regulate microRNAs (miRNAs) expression, but the prognostic value of miRNA-related DNA methylation aberration remained largely elusive in cancers including glioblastomas (GBMs). This study aimed to investigate the clinical and biological feature of miRNA methylation in GBMs of non-glioma-CpG island methylator phenotype (non-G-CIMP).

Methods: Prognostic miRNA methylation loci were analyzed, with TCGA and Rennes cohort as training sets, and independent datasets of GBMs and low-grade gliomas (LGGs) were obtained as validation sets. Read More

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http://dx.doi.org/10.1111/cns.13133DOI Listing

Ex vivo Dynamics of Human Glioblastoma Cells in a Microvasculature-on-a-Chip System Correlates with Tumor Heterogeneity and Subtypes.

Adv Sci (Weinh) 2019 Apr 10;6(8):1801531. Epub 2019 Feb 10.

Department of Biomedical Engineering Yale University New Haven CT 06520 USA.

The perivascular niche (PVN) plays an essential role in brain tumor stem-like cell (BTSC) fate control, tumor invasion, and therapeutic resistance. Here, a microvasculature-on-a-chip system as a PVN model is used to evaluate the ex vivo dynamics of BTSCs from ten glioblastoma patients. BTSCs are found to preferentially localize in the perivascular zone, where they exhibit either the lowest motility, as in quiescent cells, or the highest motility, as in the invasive phenotype, with migration over long distance. Read More

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http://dx.doi.org/10.1002/advs.201801531DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6468969PMC

Inhibition of human glioblastoma cell invasion involves PION@E6 mediated autophagy process.

Cancer Manag Res 2019 29;11:2643-2652. Epub 2019 Mar 29.

Affiliated Hospital of Guilin Medical University, Guilin Medical University, Guangxi, People's Republic of China,

Background: Glioblastoma (GBM) is the most severe brain cancer due to its ability to invade surrounding brain tissue. Iron oxide nanoparticles (ION) could effectively induce a decrease of cell migration/invasion. Also IONs could generate ROS stress which induces autophagy elevation. Read More

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http://dx.doi.org/10.2147/CMAR.S200151DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446987PMC

Pristimerin Inhibits Glioma Progression by Targeting AGO2 and PTPN1 Expression via miR-542-5p.

Biosci Rep 2019 Apr 23. Epub 2019 Apr 23.

The Sixth Hospital Affiliated to Guangzhou Medical University, guangzhou, China

Glioblastoma Multiform  is the most common and malignant primary tumor of the central nervous system in adults, the high recurrence rate and poor prognosis are critical priorities. Pristimerin is a naturally occurring quinone methide triterpenoid isolated from the and H families. Its anticancer effects have garnered considerable attention; nonetheless, the mechanisms of action remain unknown. Read More

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http://dx.doi.org/10.1042/BSR20182389DOI Listing

The French glioblastoma biobank (FGB): a national clinicobiological database.

J Transl Med 2019 Apr 23;17(1):133. Epub 2019 Apr 23.

Département de Neurochirurgie, CHU, 4 rue Larrey, 49 933, Angers Cedex 9, France.

Background: Glioblastomas (GB) are the most common and lethal primary brain tumors. Significant progress has been made toward identifying potential risk factors for GB and diagnostic and prognostic biomarkers. However, the current standard of care for newly diagnosed GB, the Stupp protocol, has remained unchanged for over a decade. Read More

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http://dx.doi.org/10.1186/s12967-019-1859-6DOI Listing

Advances in Targeting the Epidermal Growth Factor Receptor Pathway by Synthetic Products and Its Regulation by Epigenetic Modulators As a Therapy for Glioblastoma.

Cells 2019 Apr 12;8(4). Epub 2019 Apr 12.

State Key Laboratory of Silkworm Genome Biology, Southwest University, Chongqing 400715, China.

Glioma is the most common primary tumor of the nervous system, and approximately 50% of patients exhibit the most aggressive form of the cancer, glioblastoma. The biological function of epidermal growth factor receptor (EGFR) in tumorigenesis and progression has been established in various types of cancers, since it is overexpressed, mutated, or dysregulated. Its overexpression has been shown to be associated with enhanced metastatic potential in glioblastoma, with EGFR at the top of a downstream signaling cascade that controls basic functional properties of glioblastoma cells such as survival, cell proliferation, and migration. Read More

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http://dx.doi.org/10.3390/cells8040350DOI Listing

Transient Receptor Potential Mucolipin-1 Channels in Glioblastoma: Role in Patient's Survival.

Cancers (Basel) 2019 Apr 12;11(4). Epub 2019 Apr 12.

School of Pharmacy, University of Camerino, 62032 Camerino, Italy.

A link between mucolipin channels and tumors has been recently suggested. Herein, we aim to investigate the transient receptor potential mucolipin (TRPML)-1 relevance in glioblastoma. The expression of this channel was evaluated via qRT-PCR and immunohistochemistry in biopsies from 66 glioblastoma patients and two human glioblastoma cell lines and compared to normal human brain, astrocytes, and epileptic tissues. Read More

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http://dx.doi.org/10.3390/cancers11040525DOI Listing

The Role of Platelets in Cancer Pathophysiology: Focus on Malignant Glioma.

Cancers (Basel) 2019 Apr 22;11(4). Epub 2019 Apr 22.

Department of Pharmacology, Center of Drug Absorption and Transport, University Medicine Greifswald, 17487 Greifswald, Germany.

The link between thrombocytosis and malignancy has been well known for many years and its associations with worse outcomes have been reported mainly for solid tumors. Besides measuring platelet count, it has become popular to assess platelet function in the context of malignant diseases during the last decade. Malignant gliomas differ tremendously from malignancies outside the central nervous system because they virtually never form distant metastases. Read More

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http://dx.doi.org/10.3390/cancers11040569DOI Listing

The Role Played by SLUG, an Epithelial-Mesenchymal Transition Factor, in Invasion and Therapeutic Resistance of Malignant Glioma.

Cell Mol Neurobiol 2019 Apr 22. Epub 2019 Apr 22.

Department of Neurosurgery, Chonnam National University Research Institute of Medical Science, Chonnam National University Hwasun Hospital and Medical School, 322 Seoyang-ro, Hwasun-eup, Hwasun-gun, Jeollanam-do, 58128, South Korea.

In malignant gliomas, invasive phenotype and cancer stemness promoting resurgence of residual tumor cells render treatment very difficult. Hence, identification of epithelial-mesenchymal transition (EMT) factors associated with invasion and stemness of glioma cells is critical. To address the issue, we investigated several EMT factors in hypermotile U87MG and U251 cells, orthotopic mouse glioma model, and human glioma samples. Read More

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http://dx.doi.org/10.1007/s10571-019-00677-5DOI Listing

Cytotoxic synergy between alisertib and carboplatin versus alisertib and irinotecan are inversely dependent on MGMT levels in glioblastoma cells.

J Neurooncol 2019 Apr 22. Epub 2019 Apr 22.

Department of Pathology and Laboratory Medicine, University of Louisville, Louisville, KY, 40202, USA.

Introduction: Glioblastoma remains difficult to treat and patients whose tumors express high levels of O-methylguanine DNA methyltransferase (MGMT) usually respond poorly to standard temozolomide chemotherapy. We have previously shown that the selective AURKA inhibitor alisertib potently inhibits growth of glioblastoma cells.

Methods: We used colony formation assays, annexin V binding, and western blotting to examine the effects of alisertib on the antiproliferative capabilities of carboplatin and irinotecan in glioblastoma cells. Read More

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http://dx.doi.org/10.1007/s11060-019-03164-5DOI Listing
April 2019
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Quercetin and Sodium Butyrate Synergistically Increase Apoptosis in Rat C6 and Human T98G Glioblastoma Cells Through Inhibition of Autophagy.

Neurochem Res 2019 Apr 22. Epub 2019 Apr 22.

Department of Pathology, Microbiology, and Immunology, University of South Carolina School of Medicine, 6439 Garners Ferry Road, Columbia, SC, 29209, USA.

This study investigated the efficacy of quercetin (QCT) in combination with sodium butyrate (NaB) in enhancing apoptosis in rat C6 and human T98G glioblastoma cells though blockage of autophagy under nutrient-starvation. The most synergistic doses of the drugs were determined to be 25 µM QCT and 1 mM NaB in both cell lines. After QCT and QCT + NaB treatments, autophagy quantification with acridine orange staining showed a drastic decrease in protective autophagy in the cells under nutrient-starvation. Read More

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http://dx.doi.org/10.1007/s11064-019-02802-8DOI Listing

Irradiation to Improve the Response to Immunotherapeutic Agents in Glioblastomas.

Adv Radiat Oncol 2019 Apr-Jun;4(2):268-282. Epub 2018 Nov 20.

Department of Radiation Oncology, Centre François Baclesse, Esch-sur-Alzette, Luxembourg.

Purpose: Glioblastoma (GBM) remains an incurable disease despite extensive treatment with surgical resection, irradiation, and temozolomide. In line with many other forms of aggressive cancers, GBM is currently under consideration as a target for immunotherapy. However, GBM tends to be nonimmunogenic and exhibits a microenvironment with few or no effector T cells, a relatively low nonsynonymous somatic mutational load, and a low predicted neoantigen burden. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S24521094183023
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http://dx.doi.org/10.1016/j.adro.2018.11.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6460102PMC
November 2018
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Diverse signaling mechanisms of mTOR complexes: mTORC1 and mTORC2 in forming a formidable relationship.

Adv Biol Regul 2019 Apr 11. Epub 2019 Apr 11.

Department of Neurosurgery, Westchester Medical Center / New York Medical College, Valhalla, NY, 10595, USA.

Activation of Mechanistic target of rapamycin (mTOR) signaling plays a crucial role in tumorigenesis of numerous malignancies including glioblastoma (GB). The Canonical PI3K/Akt/mTOR signaling cascade is commonly upregulated due to loss of the tumor suppressorm PTEN, a phosphatase that acts antagonistically to the kinase (PI3K) in conversion of PIP2 to PIP3. mTOR forms two multiprotein complexes, mTORC1 and mTORC2 which are composed of discrete protein binding partners to regulate cell growth, motility, and metabolism. Read More

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http://dx.doi.org/10.1016/j.jbior.2019.03.003DOI Listing

Diamond Nanoparticles Downregulate Expression of and in Glioma Cells.

Molecules 2019 Apr 19;24(8). Epub 2019 Apr 19.

Department of Veterinary and Animal Sciences, University of Copenhagen, Groennegaardsvej 3, 1870 Frederiksberg, Denmark.

Our previous studies have shown that diamond nanoparticles (NDs) exhibited antiangiogenic and proapoptotic properties in vitro in glioblastoma multiforme (GBM) cells and in tumors in vivo. Moreover, NDs inhibited adhesion, leading to the suppression of migration and invasion of GBM. In the present study, we hypothesized that the NDs might also inhibit proliferation and cell cycle in glioma cells. Read More

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http://dx.doi.org/10.3390/molecules24081549DOI Listing

Effect of Electrospun Fiber Mat Thickness and Support Method on Cell Morphology.

Nanomaterials (Basel) 2019 Apr 20;9(4). Epub 2019 Apr 20.

Department of Biomedical Engineering, The Ohio State University, Columbus, OH 43210, USA.

Electrospun fiber mats (EFMs) are highly versatile biomaterials used in a myriad of biomedical applications. Whereas some facets of EFMs are well studied and can be highly tuned (e.g. Read More

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http://dx.doi.org/10.3390/nano9040644DOI Listing

Prognostic Factors and Treatment Patterns in the Management of Giant Cell Glioblastoma.

World Neurosurg 2019 Apr 19. Epub 2019 Apr 19.

Department of Radiation Oncology, Stanford University School of Medicine, Stanford, California; Palo Alto Veterans Affairs Health Care System, Palo Alto, California. Electronic address:

Background: There is a lack of literature guiding treatment of giant cell glioblastoma (gcGBM), a rare subtype of glioblastoma (GBM). We used a national hospital-based registry to explore treatment patterns and outcomes associated with gcGBM.

Methods: Adult patients (age 18+) diagnosed with gcGBM or GBM between 2004-2014 were identified from the National Cancer Database (NCDB). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18788750193109
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http://dx.doi.org/10.1016/j.wneu.2019.04.103DOI Listing
April 2019
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Improved Model Prediction of Glioma Growth Utilizing Tissue-Specific Boundary Effects.

Math Biosci 2019 Apr 19. Epub 2019 Apr 19.

Department of Neurosurgery, Mayo Clinic, Phoenix, AZ, USA.

Kinetic parameter estimates for mathematical models of glioblastoma multiforme (GBM), derived from clinical scans, have been used to predict the occurrence of hypoxia, necrosis, response to radiation therapy, and overall survival. Modeling GBM growth in a cerebral model encounters anatomical boundaries that interfere with model calibration from clinical measurements.

Methods: The effect of boundaries is examined on both spherically symmetric and anatomical models of tumor growth. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00255564173060
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http://dx.doi.org/10.1016/j.mbs.2019.04.004DOI Listing
April 2019
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Strategies in regulating glioblastoma signaling pathways and anti-invasion therapy.

PLoS One 2019 22;14(4):e0215547. Epub 2019 Apr 22.

Department of Mathematics, Konkuk University, Seoul, Republic of Korea.

Glioblastoma multiforme is one of the most invasive type of glial tumors, which rapidly grows and commonly spreads into nearby brain tissue. It is a devastating brain cancer that often results in death within approximately 12 to 15 months after diagnosis. In this work, optimal control theory was applied to regulate intracellular signaling pathways of miR-451-AMPK-mTOR-cell cycle dynamics via glucose and drug intravenous administration infusions. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215547PLOS
April 2019
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Design, synthesis, and biological evaluation of lipophilically modified bisphenol Z derivatives.

Chem Biol Drug Des 2019 Apr 22. Epub 2019 Apr 22.

The University of Findlay, College of Pharmacy, 1000 North Main Street, Findlay, OH, 45840.

In the present study, a small library of bisphenol Z (BPZ) derivatives was synthesized and investigated for anti-proliferative effects in cultured breast and glioblastoma cell lines. Synthesized BPZ derivatives varied in molecular size, polarity, and lipophilicity. Of the 8 derivatives tested, compounds 4 and 6, both of which displayed the highest degree of lipophilicity, were most active at inducing cell death as determined by the XTT assay. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/cbdd.13531
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http://dx.doi.org/10.1111/cbdd.13531DOI Listing
April 2019
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Polycomb complex mediated epigenetic reprogramming alters TGF-β signaling via a novel EZH2/miR-490/TGIF2 axis thereby inducing migration and EMT potential in glioblastomas.

Int J Cancer 2019 Apr 22. Epub 2019 Apr 22.

Department of Biochemical Engineering and Biotechnology, Indian Institute of Technology Delhi, New Delhi- 110016, IN.

Recent advancement in understanding cancer etiology has highlighted epigenetic deregulation as an important phenomenon leading to poor prognosis in Glioblastoma (GBM). Polycomb Repressive Complex 2 (PRC2) is one such important epigenetic modifier reportedly altered in GBM. However, its defined mechanism in tumorigenesis still remains elusive. Read More

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http://dx.doi.org/10.1002/ijc.32360DOI Listing

CD164 regulates proliferation, progression, and invasion of human glioblastoma cells.

Oncotarget 2019 Mar 12;10(21):2041-2054. Epub 2019 Mar 12.

Graduate Institute of Medical Sciences, National Defense Medical Center, Taipei City 114, Taiwan, Republic of China.

Grade IV astrocytoma, also known as glioblastoma multiforme (GBM), is the most common and aggressive intracranial glial tumor. GBM is associated with very poor survival and effective treatments have remained elusive so far. Mounting evidence indicates that CD164 contributes to stemness and tumorigenesis in normal cells and is overexpressed in various tumor types, including glioblastoma. Read More

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http://dx.doi.org/10.18632/oncotarget.26724DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6459350PMC

Modulation of Biological Activities in Glioblastoma Mediated by Curcumin.

Nutr Cancer 2019 Apr 22:1-13. Epub 2019 Apr 22.

a Department of Clinical and Experimental Medicine , University of Foggia , Foggia , Italy.

Curcumin is an alkaloid with various pharmacologic properties; numerous investigations have suggested that in the Central Nervous System, Curcumin has anti-inflammatory, antimicrobial, antioxidant, and antitumor effects. Gliomas are the most common primary intracranial tumors in adults. The prognosis of glioblastoma is still dismal. Read More

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https://www.tandfonline.com/doi/full/10.1080/01635581.2019.1
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http://dx.doi.org/10.1080/01635581.2019.1604978DOI Listing
April 2019
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Furanodienone overcomes temozolomide resistance in glioblastoma through the downregulation of CSPG4-Akt-ERK signalling by inhibiting EGR1-dependent transcription.

Phytother Res 2019 Apr 21. Epub 2019 Apr 21.

Department of Neurosurgery, Shenzhen Key Laboratory of Neurosurgery, the First Affiliated Hospital of Shenzhen University, Shenzhen Second People's Hospital, 3002# Sungang Road, Futian District, Shenzhen, 518035, China.

Glioblastoma multiforme (GBM) is a highly aggressive type of brain tumour. Patients with GBM respond poorly to chemotherapy and have poor survival outcomes. Neuron-glial antigen 2 (NG2), also known as chondroitin sulphate proteoglycan 4 (CSPG4), has been shown to contribute to critical processes, such as cell survival, proliferation, and chemotherapy resistance, during glioma progression. Read More

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http://dx.doi.org/10.1002/ptr.6363DOI Listing

Skin Metastasis of Glioblastoma Multiforme: A Case Report and Literature Review.

Actas Dermosifiliogr 2019 Apr 19. Epub 2019 Apr 19.

Consorcio Hospital General Universitario de Valencia, Valencia, España.

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http://dx.doi.org/10.1016/j.ad.2018.05.017DOI Listing

Assessment of ApoC1, LuzP6, C12orf75 and OCC-1 in cystic glioblastoma using MALDI-TOF mass spectrometry, immunohistochemistry and qRT-PCR.

Med Mol Morphol 2019 Apr 20. Epub 2019 Apr 20.

Department of Neurosurgery, University Hospital Leipzig, Liebigstrasse 20, 04103, Leipzig, Germany.

Mass spectrometric analysis of glioblastoma cyst fluids has disclosed a protein peak with m/z 6424-6433. Among the proteins, potentially generating this peak are ApoC1 and LuzP6. To further elucidate protein expression of glioblastoma cells, we analyzed MALDI-TOF results of cyst fluid, performed immunohistochemistry and mRNA analysis. Read More

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http://dx.doi.org/10.1007/s00795-019-00223-8DOI Listing

CEP55 promoted the migration, invasion and neuroshpere formation of the glioma cell line U251.

Neurosci Lett 2019 Apr 18. Epub 2019 Apr 18.

Department of cell biology and Neurobiology, Xuzhou Key Laboratory of Neurobiology, Xuzhou Medical University, Xuzhou 221004, Jiangsu, China. Electronic address:

Glioma stem cells (GSC) were important for Glioblastoma (GBM) initiation and chemotherapy resistance. Centrosomal protein of 55 kDa (CEP55) was a biomarker for multiple cancers. However, roles and mechanism of CEP55 in glioma tumorigenesis and stemness maintains of stem like cells was still unclear. Read More

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http://dx.doi.org/10.1016/j.neulet.2019.04.038DOI Listing

Role of multidimensional assessment of frailty in predicting outcomes in elderly glioblastoma patients treated with adjuvant concurrent chemo-radiation.

J Geriatr Oncol 2019 Apr 17. Epub 2019 Apr 17.

Radiation Oncology Unit, AUSL - IRCCS di Reggio Emilia, Italy.. Electronic address:

Background: Our aim was to evaluate the impact of comorbidities, clinical and biological factors on outcomes in elderly GBM patients treated with surgery followed by concurrent radiation (RT) and Temozolomide (TMZ).

Materials And Methods: Our sample includes 34 elderly patients with GBM who treated from January 2013 to December 2017. We collected data regarding age, extension of surgery, use of current medications, KPS, presenting symptoms, Prognostic Nutritional Index (PNI), Charlson Co-morbidity Index (CCI) and Frailty Index (FI). Read More

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http://dx.doi.org/10.1016/j.jgo.2019.03.009DOI Listing

Low perfusion compartments in glioblastoma quantified by advanced magnetic resonance imaging and correlated with patient survival.

Radiother Oncol 2019 May 31;134:17-24. Epub 2019 Jan 31.

Cambridge Brain Tumour Imaging Laboratory, Division of Neurosurgery, Department of Clinical Neuroscience, University of Cambridge, UK; Wolfson Brain Imaging Centre, Department of Clinical Neuroscience, University of Cambridge, UK.

Background And Purpose: Glioblastoma exhibits profound intratumoral heterogeneity in perfusion. Particularly, low perfusion may induce treatment resistance. Thus, imaging approaches that define low perfusion compartments are crucial for clinical management. Read More

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http://dx.doi.org/10.1016/j.radonc.2019.01.008DOI Listing

Association between supratotal glioblastoma resection and patient survival: a systematic review and meta-analysis.

World Neurosurg 2019 Apr 17. Epub 2019 Apr 17.

Department of Radiology, Erasmus MC, University Medical Center Rotterdam.

Background: Gross total resection (GTR) of contrast enhancement (CE) improves survival of glioblastoma (GBM) patients. However, GBM infiltrates into brain parenchyma, beyond CE. It remains unclear whether resection beyond CE (supratotal resection, SPTR) improves survival without causing additional neurological deficits. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.04.092DOI Listing
April 2019
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Primary cilium and brain aging: role in neural stem cells, neurodegenerative diseases and glioblastoma.

Ageing Res Rev 2019 Apr 17. Epub 2019 Apr 17.

Cellular Oncology group, Biodonostia Health Research Institute, San Sebastian, Spain; CIBER de Fragilidad y Envejecimiento Saludable (CIBERfes), Madrid, Spain; IKERBASQUE, Basque Foundation, Bilbao, Spain. Electronic address:

Brain aging is characterized by a progressive loss of tissue integrity and function as a consequence of impaired homeostasis and regeneration capacities. The primary cilium is a highly conserved organelle that projects from the cell surface in a single copy in virtually all mammalian cell types including neural stem/progenitors cells and neurons. Increasing evidence in the last decade points out that primary cilium could be a relevant mediator of neural stem cell activity, neurogenesis, neuronal maturation and maintenance, and brain tumorigenesis. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15681637183030
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http://dx.doi.org/10.1016/j.arr.2019.04.004DOI Listing
April 2019
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Transcriptional activation of SIRT6 via FKHRL1/FOXO3a inhibits the Warburg effect in glioblastoma cells.

Cell Signal 2019 Apr 17. Epub 2019 Apr 17.

State Key Laboratory of Silkworm Genome Biology, Institute of Sericulture and Systems Biology, Southwest University, Beibei, Chongqing 400716, China; Engineering Research Center for Cancer Biomedical and Translational Medicine, Southwest University, Beibei, Chongqing 400716, China; Chongqing Engineering and Technology Research Center for Silk Biomaterials and Regenerative Medicine, Southwest University, Beibei, Chongqing 400716, China; Cancer Center, Medical Research Institute, Southwest University, Beibei, Chongqing, China. Electronic address:

Glioblastoma (GBM) is the most aggressive and malignant form of brain tumors. However, its molecular mechanisms of tumorigenesis and cancer development remained to elucidate. Here, we reported FKHRL1, also called as FOXO3a, was an anti-cancer factor that inhibited the Warburg effect in GBM. Read More

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http://dx.doi.org/10.1016/j.cellsig.2019.04.009DOI Listing

MICAL2 is expressed in cancer associated neo-angiogenic capillary endothelia and it is required for endothelial cell viability, motility and VEGF response.

Biochim Biophys Acta Mol Basis Dis 2019 Apr 17. Epub 2019 Apr 17.

Scuola Superiore Sant'Anna, Institute of Life Sciences, 56124 Pisa, Italy. Electronic address:

The capacity of inducing angiogenesis is a recognized hallmark of cancer cells. The cancer microenvironment, characterized by hypoxia and inflammatory signals, promotes proliferation, migration and activation of quiescent endothelial cells (EC) from surrounding vascular network. Current anti-angiogenic drugs present side effects, temporary efficacy, and issues of primary resistance, thereby calling for the identification of new therapeutic targets. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09254439193011
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http://dx.doi.org/10.1016/j.bbadis.2019.04.008DOI Listing
April 2019
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Isocitrate dehydrogenase1 mutation reduces the pericyte coverage of microvessels in astrocytic tumours.

J Neurooncol 2019 Apr 19. Epub 2019 Apr 19.

Department of Neurology, Tangdu Hospital, The Fourth Military Medical University, Xi'an, 710032, Shaanxi, China.

Introduction: Tumour-associated angiogenesis is associated with the malignancy and poor prognosis of glioma. Isocitrate dehydrogenase (IDH) mutations are present in the majority of lower-grade (WHO grade II and III) and secondary glioblastomas, but their roles in tumour angiogenesis remain unclear.

Methods: Using magnetic resonance imaging (MRI), the cerebral blood flow (CBF) of IDH-mutated glioma was measured and compared with the IDH-wildtype glioma. Read More

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http://link.springer.com/10.1007/s11060-019-03156-5
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http://dx.doi.org/10.1007/s11060-019-03156-5DOI Listing
April 2019
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Antagonism between the RNA binding protein Musashi1 and miR-137 and its potential impact on neurogenesis and glioblastoma development.

RNA 2019 Apr 19. Epub 2019 Apr 19.

UTHSCSA;

RNA binding proteins (RBPs) and miRNAs are critical gene expression regulators that interact with one another in cooperative and antagonistic fashions. We identified Musashi1 (Msi1) and miR-137 as regulators of a molecular switch between self-renewal and differentiation. Msi1 and miR-137 have opposite expression patterns and functions, and Msi1 is repressed by miR-137. Read More

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http://dx.doi.org/10.1261/rna.069211.118DOI Listing

Targeted Delivery of Nanoparticulate Cytochrome C into Glioma Cells Through the Proton-Coupled Folate Transporter.

Biomolecules 2019 Apr 18;9(4). Epub 2019 Apr 18.

Department of Biochemistry, Universidad Central del Caribe, School of Medicine, Bayamon, PR 00956, USA.

In this study, we identified the proton-coupled folate transporter (PCFT) as a route for targeted delivery of drugs to some gliomas. Using the techniques of confocal imaging, quantitative reverse transcription-polymerase chain reaction (qRT-PCR), and small interfering (siRNA) knockdown against the PCFT, we demonstrated that Gl261 and A172 glioma cells, but not U87 and primary cultured astrocytes, express the PCFT, which provides selective internalization of folic acid (FA)-conjugated cytochrome c-containing nanoparticles (FA-Cyt c NPs), followed by cell death. The FA-Cyt c NPs (100 µg/mL), had no cytotoxic effects in astrocytes but caused death in glioma cells, according to their level of expression of PCFT. Read More

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https://www.mdpi.com/2218-273X/9/4/154
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http://dx.doi.org/10.3390/biom9040154DOI Listing
April 2019
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Effect of glycolysis inhibition by miR-448 on glioma radiosensitivity.

J Neurosurg 2019 Apr 19:1-9. Epub 2019 Apr 19.

4Department of Neurosurgery, The Affiliated Hospital of Xiangnan University, Chenzhou, Hunan, People's Republic of China.

OBJECTIVEAlthough glucose metabolism reengineering is a typical feature of various tumors, including glioma, key regulators of glycolytic reprogramming are still poorly understood. The authors sought to investigate whether glycolysis inhibition by microRNA (miR)-448 increases radiosensitivity in glioma cells.METHODSThe authors used glioma tissue samples from glioma patients, cells from glioblastoma (GBM) cell lines and normal human astrocyte cells, and subcutaneous tumor-bearing U87 cells in mice to examine the effects of signaling regulation by miR-448 in the response of glioma tissues and cells to radiation treatment. Read More

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https://thejns.org/view/journals/j-neurosurg/aop/article-10.
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http://dx.doi.org/10.3171/2018.12.JNS181798DOI Listing
April 2019
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Dynamic contrast-enhanced T1-weighted perfusion MR imaging identifies glioblastoma immunohistochemical biomarkers via tumoral and peritumoral approach: A pilot study.

World Neurosurg 2019 Apr 16. Epub 2019 Apr 16.

Department of Radiology, Uludag University Faculty of Medicine, Gorukle Street, Bursa, Turkey. Electronic address:

Objective: We aimed to evaluate the utility of dynamic contrast-enhanced T1-weighted perfusion MR imaging (DCE-pMRI) to predict certain immunohistochemical (IHC) biomarkers of glioblastoma (GB) in this pilot study.

Methods: We retrospectively reviewed thirty-six patients (M/F: 25/11, mean age: 53, age range: 29-85 years) who had pretreatment DCE-pMRI with IHC analysis of their excised GBs. ROIs of the enhancing tumor (ER) and non-enhancing peritumoral region (NER) were used to calculate DCE-pMRI parameters of Ktrans, Kep, Ve, iAUC, and MaxSlope. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.04.089DOI Listing

Synergistic effect of arsenic trioxide, vismodegib and temozolomide on glioblastoma.

Oncol Rep 2019 Jun 4;41(6):3404-3412. Epub 2019 Apr 4.

Department of Medical Joint Materials, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima 890‑8520, Japan.

The treatment of glioblastoma is a critical health issue, owing to its resistance to chemotherapy. The current standard of treatment is surgical resection, followed by adjuvant radiotherapy and temozolomide treatment. Long‑term local treatment of glioblastoma is rarely achieved and the majority of the patients undergo relapse. Read More

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http://www.spandidos-publications.com/10.3892/or.2019.7100
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http://dx.doi.org/10.3892/or.2019.7100DOI Listing
June 2019
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Upregulation of LGMNP1 confers radiotherapy resistance in glioblastoma.

Oncol Rep 2019 Jun 18;41(6):3435-3443. Epub 2019 Apr 18.

Department of Neurosurgery, Shanghai Pudong Hospital, Fudan University, Pudong, Shanghai 200120, P.R. China.

Glioblastoma is a lethal brain tumor type, which is frequently resistant to radiotherapy. The aim of the present study was to explore the function of legumain pseudogene 1 (LGMNP1) on radioresistance in glioblastoma. Reverse transcription‑quantitative PCR was used to detect the relative expression of LGMNP1 in glioma cell lines after radiotherapy. Read More

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http://dx.doi.org/10.3892/or.2019.7128DOI Listing

Machine-learning based radiogenomics analysis of MRI features and metagenes in glioblastoma multiforme patients with different survival time.

J Cell Mol Med 2019 Apr 18. Epub 2019 Apr 18.

Department of Interventional Radiology, Guizhou Provincial People's Hospital, Guiyang, Guizhou, China.

Background: This study aimed to examine multi-dimensional MRI features' predictability on survival outcome and associations with differentially expressed Genes (RNA Sequencing) in groups of glioblastoma multiforme (GBM) patients.

Methods: Radiomics features were extracted from segmented lesions of T2-FLAIR MRI data of 137 GBM patients. Radiomics features include intensity, shape and textural features in seven classes were included in the analysis. Read More

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http://dx.doi.org/10.1111/jcmm.14328DOI Listing

Cross-Polarization Optical Coherence Tomography for Brain Tumor Imaging.

Front Oncol 2019 2;9:201. Epub 2019 Apr 2.

Laboratory of Optical Coherence Tomography, Research Institute of Experimental Oncology and Biomedical Technologies, Privolzhsky Research Medical University, Nizhny Novgorod, Russia.

This paper considers valuable visual assessment criteria for distinguishing between tumorous and non-tumorous tissues, intraoperatively, using cross-polarization OCT (CP OCT)-OCT with a functional extension, that enables detection of the polarization properties of the tissues in addition to their conventional light scattering. The study was performed on 176 human specimens obtained from 30 glioma patients. To measure the degree to which the typical parameters of CP OCT images can be matched to the actual histology, 100 images of tumors and white matter were selected for visual analysis to be undertaken by three "single-blinded" investigators. Read More

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https://www.frontiersin.org/article/10.3389/fonc.2019.00201/
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http://dx.doi.org/10.3389/fonc.2019.00201DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6455095PMC
April 2019
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Alkylaminophenol Induces G1/S Phase Cell Cycle Arrest in Glioblastoma Cells Through p53 and Cyclin-Dependent Kinase Signaling Pathway.

Front Pharmacol 2019 2;10:330. Epub 2019 Apr 2.

Molecular Signaling Lab, Faculty of Medicine and Health Technology, Tampere University and BioMediTech, Tampere, Finland.

Glioblastoma (GBM) is the most common type of malignant brain tumor in adults. We show here that small molecule 2-[(3,4-dihydroquinolin-1(2H)-yl)(p-tolyl)methyl]phenol (THTMP), a potential anticancer agent, increases the human glioblastoma cell death. Its mechanism of action and the interaction of selective signaling pathways remain elusive. Read More

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http://dx.doi.org/10.3389/fphar.2019.00330DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454069PMC

Mindbomb Homolog-1 Index in the Prognosis of High-Grade Glioma and Its Clinicopathological Correlation.

J Neurosci Rural Pract 2019 Apr-Jun;10(2):185-193

Department of Neuropathology, Human Brain Tissue Repository, NIMHANS, Bengaluru, Karnataka, India.

Introduction: Gliomas are the most common brain tumors in adults originating from the glial cells. Glioblastoma multiforme is the most malignant and frequent among all gliomas. In recent years, the antibody Mindbomb Homolog-1 (MIB-1) has evolved as a measure of the proliferative nature of the glial tumors. Read More

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http://dx.doi.org/10.4103/jnrp.jnrp_374_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454943PMC

Anti-Stress and Glial Differentiation Effects of a Novel Combination of Cucurbitacin B and Withanone (CucWi-N): Experimental Evidence.

Ann Neurosci 2018 Dec 5;25(4):201-209. Epub 2018 Jul 5.

DBT-AIST International laboratory for Advanced Biomedicine (DAILAB), National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Japan.

Background: Natural extracts and compounds used in traditional home medicine are known for their safety and a variety of health promoting and therapeutic potentials. In contrast to the single molecule mediated targets, the combinational therapies are preferred for their multi-functional and limited toxic regimens and may be useful for disease therapeutics as well as to increase the quality of life during a variety of environmental stresses.

Purpose: We aimed to combine the active ingredients of Chinese () and Indian () ginsengs to develop a natural, efficient, and welfare combinatorial mixture with high anti-stress and glial differentiation potentials. Read More

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https://www.karger.com/Article/FullText/490693
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http://dx.doi.org/10.1159/000490693DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6470339PMC
December 2018
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Cancer and the dopamine D2 receptor: a pharmacological perspective.

J Pharmacol Exp Ther 2019 Apr 18. Epub 2019 Apr 18.

Penn State University College of Medicine

The dopamine D2 receptor (D2R) family is upregulated in many cancers, and tied to stemness, while cancer risk may correlate with dopamine-related disorders such as schizophrenia and Parkinson's disease. D2R antagonists also have anticancer efficacy in cell culture and animal models where they reduce tumor growth, induce autophagy, affect lipid metabolism, and cause apoptosis, among other effects. This has led to the hypothesis that D2R ligands are a novel approach to cancer chemotherapy, a particularly appealing concept because of the large number of approved and experimental drugs of this class. Read More

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http://jpet.aspetjournals.org/lookup/doi/10.1124/jpet.119.25
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http://dx.doi.org/10.1124/jpet.119.256818DOI Listing
April 2019
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Practical Bioinformatic DNA-Sequencing Pipeline for Detecting Oncogene Amplification and EGFRvIII Mutational Status in Clinical Glioblastoma Samples.

J Mol Diagn 2019 Apr 12. Epub 2019 Apr 12.

Fishberg Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York; Department of Pathology and Laboratory Medicine, Icahn School of Medicine at Mount Sinai, New York, New York. Electronic address:

Glioblastoma is a malignant brain tumor with dismal prognosis. Oncogenic mutations in glioblastoma frequently affect receptor tyrosine kinase pathway components that are challenging to quantify because of heterogeneous expression. EGFRvIII, a common oncogenic receptor tyrosine kinase mutant protein in glioblastoma, potentiates tumor malignancy and is an emerging tumor-specific immunotarget, underlining the need for its more accessible and quantitative detection. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15251578183016
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http://dx.doi.org/10.1016/j.jmoldx.2019.02.001DOI Listing
April 2019
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Identifying optimal clinical scenarios for synchrotron microbeam radiation therapy: A treatment planning study.

Phys Med 2019 Apr 30;60:111-119. Epub 2019 Mar 30.

Alfred Health Radiation Oncology, Alfred Health, Melbourne, Victoria 3004, Australia; Department of Surgery, Central Clinical School, Monash University, Melbourne, Victoria 3004, Australia. Electronic address:

Purpose: Synchrotron Microbeam Radiation Therapy (MRT) is a pre-clinical modality characterised by spatial dose fractionation on a microscopic scale. Treatment planning studies using clinical datasets have not yet been conducted. Our aim was to investigate MRT dose-distributions in scenarios refractory to conventional treatment and to identify optimal settings for a future Phase I trial. Read More

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http://dx.doi.org/10.1016/j.ejmp.2019.03.019DOI Listing