44,457 results match your criteria Glioblastoma Multiforme


Convection enhanced delivery of light responsive antigen capturing oxygen generators for chemo-phototherapy triggered adaptive immunity.

Biomaterials 2021 Jun 16;275:120974. Epub 2021 Jun 16.

Department of Chemical and Biomolecular Engineering, National University of Singapore, 4 Engineering Drive 4, Singapore, 117585, Singapore. Electronic address:

In recent years, combination therapy has emerged as the cornerstone of clinical practice in treating glioblastoma multiforme. However, their ability to trigger and leverage the body's adaptive immunity has rarely been studied. Tumour heterogeneity, the presence of the blood-brain barrier, and an immunosuppressive tumor microenvironment play a crucial role in the 90% local tumor recurrence post-treatment. Read More

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Microphysiological systems to study tumor-stroma interactions in brain cancer.

Brain Res Bull 2021 Jun 21. Epub 2021 Jun 21.

Department of Chemical and Biomolecular Engineering, Carl R Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA. Electronic address:

Brain tumors still lack effective treatments, and the mechanisms of tumor progression and therapeutic resistance are unclear. Multiple parameters affect cancer prognosis (e.g. Read More

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Serine hydroxymethyltransferase 2 expression promotes tumorigenesis in rhabdomyosarcoma with 12q13-14 amplification.

J Clin Invest 2021 Jun 24. Epub 2021 Jun 24.

Laboratory of Pathology, National Cancer Institute, Bethesda, United States of America.

The 12q13-q14 chromosomal region is recurrently amplified in 25% of fusion-positive (FP) rhabdomyosarcoma (RMS) cases and is associated with a poor prognosis. To identify amplified oncogenes in FP RMS, we compared the size, gene composition and expression of 12q13-q14 amplicons in FP RMS with other cancer categories (glioblastoma multiforme, lung adenocarcinoma and liposarcoma) in which 12q13-q14 amplification frequently occurs. We uncovered a 0. Read More

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Genomic Classification and Clinical Outcome in Rhabdomyosarcoma: A Report From an International Consortium.

J Clin Oncol 2021 Jun 24:JCO2003060. Epub 2021 Jun 24.

Department of Pediatrics, Seattle Children's Hospital, Fred Hutchinson Cancer Research Center, University of Washington, Seattle, WA.

Purpose: Rhabdomyosarcoma is the most common soft tissue sarcoma of childhood. Despite aggressive therapy, the 5-year survival rate for patients with metastatic or recurrent disease remains poor, and beyond fusion status, no genomic markers are available for risk stratification. We present an international consortium study designed to determine the incidence of driver mutations and their association with clinical outcome. Read More

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Nitric Oxide Synthase Potentiates the Resistance of Cancer Cell Lines to Anticancer Chemotherapeutics.

Anticancer Agents Med Chem 2021 Jun 22. Epub 2021 Jun 22.

Doping Research Chair, Department of Zoology, College of Science, King Saud University PO. Box: 2455, Riyadh, 11451, Saudi Arabia.

Background: Despite the advancement in the fields of medical science and molecular biology, cancer is still the leading cause of death worldwide. Chemotherapy is a choice for treatment; however, the acquisition of chemo-resistance is a major impediment to cancer management. Many mechanisms have been postulated regarding the acquisition of chemo-resistance in breast cancer the impact on cellular signaling and the induction of apoptosis in tumour cells. Read More

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AmotL2, IQGAP1, and FKBP51 Scaffold Proteins in Glioblastoma Stem Cell Niches.

J Histochem Cytochem 2021 Jun 24:221554211025480. Epub 2021 Jun 24.

Department of Bioquímica, Microbiología, Biología Celular y Genética, Universidad de La Laguna, San Cristóbal de La Laguna, Spain.

Glioma stem cells (GSCs) live in a continuous process of stemness reprogramming to achieve specific cell commitment within the so-called GSC niches, specifically located in periarteriolar regions. In this review, we analyze the expression levels, cellular and subcellular location, and role of three scaffold proteins (IQGAP1, FKBP51, and AmotL2) in GSC niches. Scaffold proteins contribute to cell differentiation, migration, and angiogenesis in glioblastoma. Read More

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Repurposing of Anticancer Stem Cell Drugs in Brain Tumors.

J Histochem Cytochem 2021 Jun 24:221554211025482. Epub 2021 Jun 24.

Arkadi M. Rywlin M.D. Department of Pathology and Laboratory Medicine, Mount Sinai Medical Center, Miami Beach, Florida.

Brain tumors in adults may be infrequent when compared with other cancer etiologies, but they remain one of the deadliest with bleak survival rates. Current treatment modalities encompass surgical resection, chemotherapy, and radiotherapy. However, increasing resistance rates are being witnessed, and this has been attributed, in part, to cancer stem cells (CSCs). Read More

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The Ependymal Region Prevents Glioblastoma From Penetrating Into the Ventricle via a Nonmechanical Force.

Front Neuroanat 2021 7;15:679405. Epub 2021 Jun 7.

Department of Neurosurgery, Nanfang Hospital, Southern Medical University, Guangzhou, China.

Background: Intraventricular penetration is rare in glioblastoma (GBM). Whether the ependymal region including the ependyma and subventricular zone (SVZ) can prevent GBM invasion remains unclear.

Methods: Magnetic resonance imaging (MRI) and haematoxylin-eosin (HE) staining were performed to evaluate the size and anatomical locations of GBM. Read More

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Doxorubicin Delivered via ApoE-Directed Reduction-Sensitive Polymersomes Potently Inhibit Orthotopic Human Glioblastoma Xenografts in Nude Mice.

Int J Nanomedicine 2021 15;16:4105-4115. Epub 2021 Jun 15.

Department of Neurosurgery, The Second Affiliated Hospital of Soochow University, Suzhou, 215004, People's Republic of China.

Purpose: Glioblastoma multiforme (GBM) poorly responds to chemotherapy owing to the existence of blood-brain barriers (BBB). It has been a long desire to develop BBB-permeable vehicles to facilitate drug targeting to GBM.

Method And Results: Here, we report that doxorubicin hydrochloride loaded in ApoE peptide-functionalized reduction-sensitive polymersomes (ApoE-PS-DOX) induces potent therapy of orthotopic U-87 MG model in nude mice. Read More

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Serum protein triplet TGF-β1, TIMP-1, and YKL-40 serve as diagnostic and prognostic profile for astrocytoma.

Sci Rep 2021 Jun 23;11(1):13100. Epub 2021 Jun 23.

Laboratory of Molecular Neurooncology, Neuroscience Institute, Lithuanian University of Health Sciences, Eiveniu str. 4, 50161, Kaunas, Lithuania.

Astrocytoma is the most common glial tumour of the CNS. The most malignant form is grade IV Astrocytoma, also called Glioblastoma. Due to its heterogeneity, aggressiveness and lethal nature scientists are trying to find less invasive methods for early prediction of tumour onset, recurrence, response to therapy and patients' survival. Read More

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Tumor-associated hematopoietic stem and progenitor cells positively linked to glioblastoma progression.

Nat Commun 2021 Jun 23;12(1):3895. Epub 2021 Jun 23.

DKFZ-Division Translational Neurooncology at the West German Cancer Center (WTZ), University Hospital Essen/University of Duisburg-Essen, Essen, Germany.

Brain tumors are typically immunosuppressive and refractory to immunotherapies for reasons that remain poorly understood. The unbiased profiling of immune cell types in the tumor microenvironment may reveal immunologic networks affecting therapy and course of disease. Here we identify and validate the presence of hematopoietic stem and progenitor cells (HSPCs) within glioblastoma tissues. Read More

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Advances in the management of glioblastoma.

J Neurol Neurosurg Psychiatry 2021 Jun 23. Epub 2021 Jun 23.

Department of Neurosurgery, Oxford University Hospitals NHS Foundation Trust, Oxford, Oxfordshire, UK

Glioblastoma (GB) is the most common and most malignant primary brain tumour in adults. Despite much effort, gold standard therapy has not changed since the introduction of adjuvant temozolomide in 2005 and prognosis remains poor. Despite this, there has been significant improvement in the surgical technology and technique, that has allowed for increased rates of safe maximal resection of the tumour. Read More

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Gliosarcoma vs. glioblastoma: a retrospective case series using molecular profiling.

BMC Neurol 2021 Jun 23;21(1):231. Epub 2021 Jun 23.

Department of Medicine, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.

Background: Gliosarcoma (GS) refers to the presence of mesenchymal differentiation (as seen using light microscopy) in the setting of glioblastoma (GB, an astrocytoma, WHO Grade 4). Although the same approach to treatment is typically adopted for GS and GB, there remains some debate as to whether GS should be considered a discrete pathological entity. Differences between these tumors have not been clearly established at the molecular level. Read More

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Two mixed valence diruthenium(II,III) isomeric complexes show different anticancer properties.

Dalton Trans 2021 Jun 23. Epub 2021 Jun 23.

Department of Pharmacy, University of Pisa, Via Bonanno Pisano, 6, 56126, Pisa, Italy.

In this paper it is demonstrated that the nature of the ligands of two Ru2(ii,iii) paddlewheel complexes dramatically affects the overall anticancer properties in cells. Herein, the complex [Ru2(EB776)4Cl] was found to be more active against a glioblastoma model with respect to its isomer [Ru2(EB106)4Cl]. These different effects depend on the steric hindrance, on the allowed conformations of the complexes and on the presence of hydrophilic regions in [Ru2(EB776)4Cl], which overall lead to a lower "steric protection". Read More

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Extent of resection and survival in patients with glioblastoma multiforme: Systematic review and meta-analysis.

Medicine (Baltimore) 2021 Jun;100(25):e26432

Neurological Center, ABC Medical Center.

Background: Glioblastoma multiforme (GBM) owes an ominous prognosis: its mean overall survival is 14 months. The extent of surgical resection (ESR) highlights among factors in which an association has been found to a somewhat better prognosis. However, the association between greater ESR and prolonged overall (OS) survival is not a constant finding nor a proven cause-and-effect phenomenon. Read More

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Novel Treatment for Glioblastoma Delivered by a Radiation Responsive and Radiopaque Hydrogel.

ACS Biomater Sci Eng 2021 Jun 23. Epub 2021 Jun 23.

Department of Radiology, University of Pennsylvania, 3400 Spruce Street, 1 Silverstein Philadelphia, Pennsylvania 19104, United States.

Successful treatment of glioblastoma (GBM) is hampered by primary tumor recurrence after surgical resection and poor prognosis, despite adjuvant radiotherapy and chemotherapy. In search of improved outcomes for this disease, quisinostat appeared as a lead compound in drug screening. A delivery system was devised for this drug and to exploit current clinical methodology: an injectable hydrogel, loaded with both the quisinostat drug and radiopaque gold nanoparticles (AuNP) as contrast agent, that can release these payloads as a response to radiation. Read More

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IRDye800CW labeled uPAR-targeting peptide for fluorescence-guided glioblastoma surgery: Preclinical studies in orthotopic xenografts.

Theranostics 2021 21;11(15):7159-7174. Epub 2021 May 21.

Department of Clinical Physiology, Nuclear Medicine & PET and Cluster for Molecular Imaging, Department of Biomedical Sciences, Rigshospitalet and University of Copenhagen.

Glioblastoma (GBM) is a devastating cancer with basically no curative treatment. Even with aggressive treatment, the median survival is disappointing 14 months. Surgery remains the key treatment and the postoperative survival is determined by the extent of resection. Read More

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Oncolytic H-1 parvovirus binds to sialic acid on laminins for cell attachment and entry.

Nat Commun 2021 Jun 22;12(1):3834. Epub 2021 Jun 22.

Laboratory of Oncolytic Virus Immuno-Therapeutics, German Cancer Research Center, Heidelberg, Germany.

H-1 parvovirus (H-1PV) is a promising anticancer therapy. However, in-depth understanding of its life cycle, including the host cell factors needed for infectivity and oncolysis, is lacking. This understanding may guide the rational design of combination strategies, aid development of more effective viruses, and help identify biomarkers of susceptibility to H-1PV treatment. Read More

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Nestin is required for spindle assembly and cell cycle progression in glioblastoma cells.

Mol Cancer Res 2021 Jun 22. Epub 2021 Jun 22.

tumorigenesis, College of Pharmaceutical Sciences, Soochow University.

Nestin, a class IV intermediate filament protein, is generally considered as a putative marker of neural stem and progenitor cells in the central nervous system. Glioma is a common type of adult brain tumors, and glioblastoma (GBM) represents the most aggressive form of glioma. Here, we report that Nestin expression is significantly up-regulated in human GBM, compared with other types of glioma. Read More

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The Radiosensitizing Effect of AZD0530 in Glioblastoma and Glioblastoma Stem-like Cells.

Mol Cancer Ther 2021 Jun 22. Epub 2021 Jun 22.

Radiation Oncology Branch, National Cancer Institute

AZD0530, a potent small-molecule inhibitor of Src family kinases, is an anti-cancer drug used in the treatment of various cancers. In the case of Glioblastoma (GBM), where resistance to radiotherapy frequently occurs, Src kinase is known as one of the molecules responsible for imparting radioresistance to GBM. Thus, we evaluated the effect of AZD0530 on the radiosensitivity of human GBM cells and human glioblastoma stem-like cells (GSCs). Read More

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Role of hippocampal location and radiation dose in glioblastoma patients with hippocampal atrophy.

Radiat Oncol 2021 Jun 22;16(1):112. Epub 2021 Jun 22.

Department of Radiation Oncology, UNICANCER, Paul Strauss Comprehensive Cancer Center, Institut de Cancérologie Strasbourg Europe (ICANS), 17 Rue Albert Calmette, BP 23025, 67033, Strasbourg, France.

Background: The hippocampus is a critical organ for irradiation. Thus, we explored changes in hippocampal volume according to the dose delivered and the location relative to the glioblastoma.

Methods: All patients were treated for glioblastoma with surgery, concomitant radiotherapy and temozolomide, and adjuvant temozolomide. Read More

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Analysis of exosome-derived microRNAs reveals insights of intercellular communication during invasion of breast, prostate and glioblastoma cancer cells.

Cell Adh Migr 2021 Dec;15(1):180-201

Fondazione Pisana per La Scienza, Pisa, Italy.

MiRNAs represent a mechanism that regulates gene expression in many pathological conditions. Exosomes are known to be secreted from all types of cells, and the exosomes-released molecules are crucial messengers that can regulate cellular processes. We investigated the miRNAs content of exosomes released by cancer cells during the invasion . Read More

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December 2021

[Dynamic11C-methionine PET/CT in differential diagnosis of brain gliomas].

Zh Vopr Neirokhir Im N N Burdenko 2021 ;85(3):5-13

Burdenko Center of Neurosurgery, Moscow, Russia.

Objective: To evaluate the possibilities of dynamic preoperative C-methionine (MET) PET/CT in differential diagnosis of various types of brain gliomas in adults.

Material And Methods: The study included 74 patients aged 48±14 years with supratentorial gliomas: Grade IV - glioblastoma (GB, =33), Grade III - anaplastic oligodendroglioma (AOD, =10) and anaplastic astrocytoma (AA, =12), Grade II - diffuse astrocytoma (DA, =13) and oligodendroglioma (OD, =6). All patients underwent standard MRI and dynamic MET PET/CT within 20 minutes after intravenous injection of radiopharmaceutical. Read More

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A Cohort Study on Prognostic Factors for Laser Interstitial Thermal Therapy Success in Newly Diagnosed Glioblastoma.

Neurosurgery 2021 Jun 22. Epub 2021 Jun 22.

Department of Neurosurgery, University of Miami School of Medicine, Miami, Florida, USA.

Background: Laser interstitial thermal therapy (LITT) is a promising approach for cytoreduction of deep-seated gliomas. However, parameters contributing to treatment success remain unclear.

Objective: To identify extent of ablation (EOA) and time to chemotherapy (TTC) as predictors of improved overall and progression-free survival (OS, PFS) and suggest laser parameters to achieve optimal EOA. Read More

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Overall Survival in Patients With Resected Glioblastoma Treated With Adjuvant Therapy: A Retrospective Study in a Public Hospital in Chile.

Cureus 2021 May 18;13(5):e15105. Epub 2021 May 18.

Radiotherapy, Servicio de Radioterapia, Fundación Arturo López Pérez, Santiago, CHL.

Glioblastoma (GB) is the most frequent and aggressive primary tumor of the central nervous system (CNS) in adults. Standard treatment is complete tumor resection followed by concomitant radiochemotherapy (RCT) and subsequent adjuvant temozolomide (TMZ). Information about brain tumors statistics in Latin American countries is scarce, so we aimed to measure the overall survival (OS) of patients with resected GB in a single institution in Chile. Read More

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Limited recurrence distance of glioblastoma under modern radiotherapy era.

BMC Cancer 2021 Jun 22;21(1):720. Epub 2021 Jun 22.

NHC Key Laboratory of Personalized Diagnosis and Treatment of Nasopharyngeal Carcinoma (Jiangxi Cancer Hospital of Nanchang University), 519 East Beijing Road, Nanchang, 330029, China.

Background: The optimal treatment volume for Glioblastoma multiforme (GBM) is still a subject of debate worldwide. The current study was aimed to determine the distances between recurring tumors and the edge of primary lesions, and thereby provide evidence for accurate target area delineation.

Methods: Between October 2007 and March 2019, 68 recurrent patients with GBM were included in our study. Read More

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The multifactorial roles of microglia and macrophages in the maintenance and progression of glioblastoma.

J Neuroimmunol 2021 Jun 15;357:577633. Epub 2021 Jun 15.

School of Chemistry and Molecular Biosciences, The University of Queensland, St Lucia, QLD, Australia.

The functional characteristics of glial cells, in particular microglia, have attained considerable importance in several diseases, including glioblastoma, the most hostile and malignant type of intracranial tumor. Microglia performs a highly significant role in the brain's inflammatory response mechanism. They exhibit anti-tumor properties via phagocytosis and the activation of a number of different cytotoxic substances. Read More

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Spinal cord glioblastoma multiforme in a patient with Noonan syndrome: A clinical report.

Clin Neurol Neurosurg 2021 Jun 1;207:106725. Epub 2021 Jun 1.

Department of Neurosurgery, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY, United States; Department of Neurosurgery, University at Buffalo, Buffalo, NY, United States; Department of Neurosurgery, John R. Oishei Children's Hospital, Buffalo, NY, United States. Electronic address:

Introduction: Currently, there are only 3 reported cases of central nervous system malignancies in patients with Noonan syndrome in the literature, all of which are intracranial pathologies. To our knowledge, there are no cases of spinal cord glioblastoma multiforme reported in the literature.

Case Description: We describe the case of a 12-year-old girl with Noonan syndrome who presented with back pain and new onset neurological deficits and was found to have a spinal cord lesion. Read More

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miR-424 induces apoptosis in glioblastoma cells and targets AKT1 and RAF1 oncogenes from the ERBB signaling pathway.

Eur J Pharmacol 2021 Jun 18:174273. Epub 2021 Jun 18.

- Department of Hematology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran. Electronic address:

Glioblastoma is a lethal and incurable cancer. Tumor suppressor miRNAs are promising gene therapy tools for cancer treatment. In silico, we predicted miR-424 as a tumor suppressor. Read More

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The inverse paradigm and the ancestral cell of IDH-wildtype glioblastoma.

Authors:
Enrico Brognaro

Clin Transl Oncol 2021 Jun 21. Epub 2021 Jun 21.

Department of Neurosurgery, S. Maria della Misericordia Hospital, Viale Tre Martiri, 45100, Rovigo, Italy.

Rethinking IDH-wildtype glioblastoma through its unique features can help researchers find innovative and effective treatments. It is currently emerging that, after decades of therapeutic impasse, some traditional concepts regarding IDH-wildtype glioblastoma need to be supplemented and updated to overcome therapeutic resistance. Indeed, multiple clinical aspects and recent indirect and direct experimental data are providing evidence that the supratentorial brain parenchyma becomes entirely and quiescently micro-infiltrated long before primary tumor bulk growth. Read More

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