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Eur J Ophthalmol 2022 Jun 16:11206721221109199. Epub 2022 Jun 16.

386696Service d'Ophtalmologie, 423788Hôpital de la Croix-Rousse, Hospices Civils de Lyon, France.

Purpose: To describe the effectiveness of the XEN 63 gel stent in a refractory uveitic glaucoma after failure of an Ahmed Glaucoma Valve.

Case Description: We report the case of a 54-year-old man with a history of uveitic glaucoma on his left eye due to Fuchs heterochromic iridocyclitis and neovascular glaucoma after a central retinal vein occlusion. Pre-operative intraocular pressure was 30 mmHg despite a QD (once-daily) dosed bimatoprost 0. Read More

Ocul Immunol Inflamm 2022 Jun 13:1-7. Epub 2022 Jun 13.

Uveitis Unit, Retina Division, Wills Eye Hospital, Philadelphia, Pennsylvania, USA.

Purpose: To evaluate the outcomes of gonioscopy-assisted transluminal trabeculotomy (GATT) in adult eyes with uncontrolled uveitic glaucoma.

Methods: We reviewed 16 eyes from 13 patients. Surgical success was defined as intraocular pressure (IOP) reduction >20% from baseline or IOP between 5 and 21 mmHg by the 3-month visit while on a stable number or fewer IOP-lowering agents and no need for additional glaucoma surgery. Read More

J Glaucoma 2022 Jun 2. Epub 2022 Jun 2.

Department of Ophthalmology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University.

Prcis: A Kaplan-Meier survival curve analysis showed no significant differences in success rates between UG and POAG 120 months after modified 360-degree suture trabeculotomy, which was effective for both groups in the long term.

Purpose: To examine the outcomes of modified 360-degree suture trabeculotomy in patients with uveitic glaucoma (UG) as compared to those with primary open angle glaucoma (POAG).

Methods: This was a retrospective, non-randomized, and comparative case series study. Read More

J Clin Med 2022 Apr 22;11(9). Epub 2022 Apr 22.

Department of Ophthalmology, Duke University School of Medicine, Durham, NC 27710, USA.

Herpetic anterior uveitis-associated ocular inflammation is commonly manifested with ocular hypertension and glaucoma. Relative to other viruses, cytomegalovirus (CMV) positive hypertensive anterior uveitis is associated with high recurrences of uveitis, as well as with uncontrolled intraocular pressure (IOP) and a subsequent higher requirement for future glaucoma surgery. To gain novel insights into the pathogenesis of ocular hypertension in these patients, we investigated the proteome changes of the aqueous humor (AH) derived from the CMV hypertensive anterior uveitis (CMV-HAU; = 10) patients and non-glaucoma (cataract; = 10) patients using liquid chromatography with tandem mass spectrometry. Read More

BMC Ophthalmol 2022 May 9;22(1):210. Epub 2022 May 9.

Uveitis Division, King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia.

Purpose: To evaluate the visual outcome, intraocular pressure control and trabeculectomy survival after phacoemulsification in eyes with prior trabeculectomy in uveitis associated with Vogt-Koyanagi-Harada disease (VKH).

Design: Retrospective comparative study.

Methods: Eyes with uveitic glaucoma associated with VKH who underwent mitomycin C (MMC)-enhanced trabeculectomy were included. Read More

Ophthalmologe 2022 May 26;119(5):533-546. Epub 2022 Apr 26.

Klinik und Poliklinik für Augenheilkunde, Klinikum, Universität Regensburg, Franz-Josef-Strauß-Allee 11, 93053, Regensburg, Deutschland.

Secondary open-angle glaucomas are a heterogeneous group of diseases in which a variety of pathophysiological mechanisms result in an elevation of intraocular pressure (IOP). In contrast to primary open-angle glaucoma in many cases besides IOP reduction a causal treatment is possible. This article is the second part of a review of the more frequently encountered forms of secondary open-angle glaucoma. Read More

BMC Ophthalmol 2022 Apr 14;22(1):170. Epub 2022 Apr 14.

Veterans Health Service Medical Center, Veterans Medical Research Institute, Seoul, Republic of Korea.

Background: The microbiome could trigger inflammation leading to epigenetic changes and is involved in the pathophysiology of eye diseases; however, its effect on uveitic glaucoma (UG) has not been fully investigated. This study analysed the differences in eyelid and buccal microbiomes in patients with UG using next-generation sequencing.

Methods: The eyelid and buccal specimens of 34 UG and 25 control patients were collected. Read More

BMC Ophthalmol 2022 Mar 22;22(1):130. Epub 2022 Mar 22.

Eye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan University, Shanghai, 200031, China.

Background: We aimed to analyze the clinical characteristics of secondary glaucoma related to cytomegalovirus (CMV)- and varicella zoster virus (VZV)-positive uveitis.

Methods: In this retrospective study, we enrolled patients with anterior uveitic secondary glaucoma. All the patients underwent aqueous and serum analyses for viral antibody through enzyme-linked immunosorbent assay. Read More

J Cataract Refract Surg 2022 Mar 16. Epub 2022 Mar 16.

Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong.

Purpose: To evaluate the outcomes of cataract surgery in patients with cytomegalovirus (CMV) anterior uveitis and factors associated with final visual outcome.

Setting: A single tertiary academic hospital.

Design: Retrospective case series. Read More

J Clin Med 2022 Mar 2;11(5). Epub 2022 Mar 2.

Department of Ophthalmology, Ajou University School of Medicine, 164 World Cup-ro, Yeongtong-gu, Suwon 16499, Korea.

We compared 1-year outcomes of trabeculectomy with mitomycin C (MMC) and Ahmed valve implantation with MMC as a first surgical procedure in patients with uveitic glaucoma. A total 38 eyes of 38 patients undergoing trabeculectomy ( =16) or Ahmed valve implantation ( = 22) were included. Surgical success was defined as intraocular pressure (IOP) ≤21 mmHg, IOP reduction ≥20% from baseline, no secondary glaucoma surgery, and no loss of light perception. Read More

Graefes Arch Clin Exp Ophthalmol 2022 Mar 9. Epub 2022 Mar 9.

Department of Ophthalmology, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.

Purpose: The purpose of this study was to obtain insight into cellular processes after CyPass microstent implantation into the supraciliary space. With this knowledge, we expected to find some reason for surgical failure.

Methods: Nine CyPass microstents of 8 patients with primary open-angle glaucoma (n = 1), pseudoexfoliation glaucoma (n = 5), uveitic glaucoma (n = 1), and posttraumatic open-angle glaucoma (n = 1) were explanted due to recurrence of IOP elevation, corneal decompensation, or persistent hypotony. Read More

Graefes Arch Clin Exp Ophthalmol 2022 Mar 7. Epub 2022 Mar 7.

Eye Center, Medical Center, University of Freiburg, Faculty of Medicine, Freiburg, Germany.

Introduction: Uveitic glaucoma remains challenging despite medical and surgical advancements and can potentially lead to blindness if left uncontrolled. Conservative alternatives as well as microinvasive surgeries can postpone the necessity of a highly invasive intervention. However, such procedures are still necessary to treat some refractive glaucoma cases. Read More

Clin Exp Ophthalmol 2022 03 25;50(2):232-246. Epub 2022 Jan 25.

Speciality of Ophthalmology, Save Sight Institute, Faculty of Medicine and Health, The University of Sydney, Sydney, Australia.

Childhood glaucoma represents a heterogenous group of rare ocular conditions that may result in significant sight threatening complications related to elevated intraocular pressure (IOP). It can be classified as either primary or secondary and the latter may have systemic associations. This review will be based on the work of the childhood glaucoma research network (CGRN) and will focus on the diagnosis and management of the most common types of childhood glaucoma. Read More

Br J Ophthalmol 2021 Dec 20. Epub 2021 Dec 20.

Department of Ophthalmology and Vision Sciences, University of Toronto, Toronto, Ontario, Canada.

Background: To assess the efficacy and safety of gonioscopy-assisted transluminal trabeculotomy (GATT) in uveitic glaucoma (UG).

Methods: A retrospective interventional case series in which 33 eyes of 32 patients with UG underwent GATT with or without concomitant cataract extraction and intraocular lens implantation (CE/IOL) at three Canadian treatment centres from October 2015 to 2020. The main outcome measure was surgical success defined as an intraocular pressure (IOP) ≤18 mm Hg and at least one of the following: IOP within one mm Hg of baseline on fewer glaucoma medications as compared with baseline or a 30% IOP reduction from baseline on the same or fewer medications. Read More

Graefes Arch Clin Exp Ophthalmol 2022 May 1;260(5):1633-1639. Epub 2021 Dec 1.

Department of Ophthalmology, Aarhus University Hospital, Palle Juul-Jensens Boulevard 167, 8200, Aarhus N, Denmark.

Purpose: To evaluate intravitreal 0.19 mg fluocinolone acetonide implant (FAi) (Iluvien®) for the treatment of chronic non-infectious uveitis with associated cystoid macular edema (CME).

Methods: A retrospective review of medical reports from a single Danish tertiary centre including 20 patients (20 eyes), treated with 0. Read More

J Curr Glaucoma Pract 2021 May-Aug;15(2):52-57

Department of Ophthalmology, Hospital Clinic de Barcelona, Innove Ocular-ICO Barcelona, Spain.

Aim And Objective: This study aimed to evaluate the performance of and indication for different surgical techniques in the management of uveitic glaucoma (UG).

Materials And Methods: A retrospective audit of records of all patients with UG who underwent ≥1 glaucoma surgery, between January 2007 and December 2016. The main outcomes were intraocular pressure (IOP) and the need for antihypertensive medication at each follow-up visit. Read More

Int Ophthalmol 2022 Feb 5;42(2):411-421. Epub 2021 Oct 5.

Faculty of Medicine, Mansoura University, Mansoura, Egypt.

Purpose: To compare trabeculectomy with Ologen implant(Trab-Ologen) to combined viscotrabeculotomy-synechiolysis(VTS) in uncontrolled uveitic glaucoma (UG).

Patients And Methods: A retrospective chart review of 47 patients subjected to VTS(24 eyes) or Trab-ologen(23 eyes) at Mansoura Ophthalmic Center between 2010 and 2016. The patients were evaluated on day 1, week 1, months 1, 3, 6, 12, 18, 24, 30, 36, 42, and 48. Read More

J Clin Med 2021 Sep 18;10(18). Epub 2021 Sep 18.

Department of Ophthalmology and Visual Science, St. Vincent's Hospital, College of Medicine, The Catholic University of Korea, 93 Jungbu-daero, Paldal-gu, Suwon 16247, Korea.

Purpose: The aim of this study is to investigate the structure-function characteristics and vision-related quality of life (VR-QoL) in uveitic glaucoma (UG) compared with open-angle glaucoma (OAG).

Method: The study included 69 patients with UG and 138 patients with primary open angle glaucoma, normal-tension glaucoma. A 25-item National Eye Institute Visual Function Questionnaire (VFQ-25) was used to evaluate the patients' VR-QoL. Read More

J Natl Med Assoc 2022 Jan 26;113(6):661-665. Epub 2021 Jul 26.

New York Medical College, Valhalla, NY, United States.

Acta Ophthalmol 2022 May 7;100(3):e770-e778. Epub 2021 Jul 7.

Veterans Medical Research Institute, Veterans Health Service Medical Center, Seoul, Korea.

Purpose: Microbiomes have immunoregulatory functions and may be involved in the pathophysiology of eye diseases. However, the effects of microbiomes on uveitic glaucoma (UG) and open-angle glaucoma (OAG) have not been sufficiently investigated. This study analysed differences in eyelid and buccal microbiomes between UG and OAG using metagenomic technology. Read More

Eye (Lond) 2022 Jul 1;36(7):1456-1460. Epub 2021 Jul 1.

Royal Victorian Eye and Ear Hospital, 32 Gisborne Street, East Melbourne, Victoria, Australia.

Purpose: To evaluate the 12-month outcomes of a novel posterior small incision sub-tenon ab interno technique of XEN stent insertion ('Semi-open').

Method: Consecutive eyes underwent XEN stent insertion with the Semi-open technique by two surgeons between 1st July 2018 and 30th September 2019. All cases received subconjunctival injection of 0. Read More

Am J Ophthalmol Case Rep 2021 Sep 17;23:101144. Epub 2021 Jun 17.

SUNY Downstate Medical Center, Department of Ophthalmology, USA.

Purpose: To report a case of a sterile iris abscess associated with herpes zoster ophthalmicus (HZO).

Observations: A 69-year-old African American female presented to SUNY Downstate Medical Center complaining of left-sided eye pain for two weeks. The patient had a best-corrected visual acuity of 20/30 OD and 20/200 OS. Read More

Ocul Immunol Inflamm 2021 Jun 14:1-8. Epub 2021 Jun 14.

Centre for Ophthalmology, University of Tuebingen, Tuebingen, Germany.

Evaluation of treatment efficacy of XEN45 gelstent for glaucoma secondary to Fuchs uveitis syndrome (FUS). This retrospective case series evaluated patients with glaucoma secondary to FUS, who underwent XEN45 implantation. Complete success was defined as IOP lowering of ≥ 20% and cutoff IOP at 18 mmHg. Read More

Am J Ophthalmol Case Rep 2021 Sep 24;23:101125. Epub 2021 May 24.

Ophthalmic Oncology Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Purpose: Immune checkpoint inhibitors (ICIs) are associated with a range of immune-related adverse ophthalmic events. To date, there are scant reports of ocular hypertension coupled with ICI-associated uveitis. However, in instances of ocular hypertension in the context of only mild uveitic reaction and absence of synechiae, trabeculitis is considered. Read More

Can J Ophthalmol 2021 Jun 11. Epub 2021 Jun 11.

Department of Ophthalmology, Mayo Clinic, Rochester, Minn.. Electronic address:

Objective: To compare primary selective laser trabeculoplasty (SLT) response in uveitic, steroid-induced, primary open-angle glaucoma (POAG) and pseudoexfoliative glaucoma (PEX).

Design: Single-centre retrospective case-control study.

Participants: Patients with uveitic glaucoma, steroid-induced glaucoma, POAG, or PEX who had their first SLT. Read More

Graefes Arch Clin Exp Ophthalmol 2021 Dec;259(12):3823

Wills Eye Hospital, Glaucoma Research Center, 840 Walnut Street, Suite 1140, Philadelphia, PA, 19107, USA.

J Ophthalmol 2021 21;2021:5550776. Epub 2021 May 21.

Department of Ophthalmology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan.

Purpose: To evaluate the long-term outcomes of trabeculectomy with mitomycin C (MMC-TLE) in patients with uveitic glaucoma (UG). This was a retrospective, nonrandomized case series study. MMC-TLE was performed on 50 eyes with UG between February 2001 and January 2015 at Hokkaido University Hospital. Read More

Br J Ophthalmol 2021 May 21. Epub 2021 May 21.

Department of Ophthalmology, Auckland District Health Board, Auckland, New Zealand

Aims: To examine presentation, management and long-term sequelae of ocular hypertension and uveitic glaucoma.

Methods: Retrospective observational study of all subjects with uveitic glaucoma or ocular hypertension seen in Auckland uveitis clinics over the last 10 years.

Results: A total of 188 eyes of 139 subjects with uveitic glaucoma or ocular hypertension were included for analysis. Read More

Am J Ophthalmol Case Rep 2021 Jun 22;22:101096. Epub 2021 Apr 22.

Instituto de Oftalmología y Glaucoma Vásquez, Hospital Metropolitano, Quito, Ecuador.

Background: The number of Hansen's disease cases in Latin America and the Caribbean has decreased in the last decade; nevertheless, the region is still struggling with infections caused by This is a case report that portrays the diagnostic and management challenges associated with atypical uveitic glaucoma that is due to Hansen's disease.

Case Presentation: A 62-year-old female was referred with a 2-year history of anterior uveitis of unknown etiology and ocular hypertension. Past medical history and general physical examination were unremarkable. Read More

Lasers Med Sci 2022 Mar 18;37(2):949-959. Epub 2021 May 18.

Department of Ophthalmology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100730, China.

This study compared the efficacy of modified CO laser-assisted sclerectomy surgery (CLASS) with combined CLASS and trabeculectomy (CLASS-TRAB) in patients with uveitic glaucoma (UG). UG patients who underwent CLASS-TRAB between August 2015 and April 2019 were retrospectively compared with a control group who underwent a modified CLASS standalone procedure during the same period. Visual acuity, intraocular pressure (IOP), use of supplemental medical therapy and postoperative complications were recorded at baseline, 1 week, 3 months, 6 months and 12 months. Read More