1,619 results match your criteria Glaucoma Unilateral


Leber Hereditary Optic Neuropathy: Case Report and Literature Review.

Cureus 2020 Apr 20;12(4):e7745. Epub 2020 Apr 20.

Neurology, Marcus Neuroscience Institute, Boca Raton Regional Hospital, Boca Raton, USA.

Leber hereditary optic neuropathy (LHON) is a genetic condition that typically presents with unilateral, painless, sub-acute central vision loss followed by contralateral vision loss after a few weeks to months. It is a rare disease that typically affects young adults - men more than women - and is a relatively common cause of blindness. It is due to a mutation in mitochondrial DNA (mtDNA). Read More

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http://dx.doi.org/10.7759/cureus.7745DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7241220PMC

A novel rat model of ocular hypertension by a single intracameral injection of cross-linked hyaluronic acid hydrogel (Healaflow ).

Basic Clin Pharmacol Toxicol 2020 May 7. Epub 2020 May 7.

Department of ophthalmology, The First Medical Center, Chinese PLA General Hospital, Beijing, 100853, People's Republic of China.

Purpose: To create a novel animal model of ocular hypertension via the intracameral injection of Healaflow.

Methods: Unilateral chronic ocular hypertension model of rats was created by the intracameral injection of 3 μl Healaflow. The IOP of subjects was monitored. Read More

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http://dx.doi.org/10.1111/bcpt.13430DOI Listing

Surgical outcomes of Ahmed glaucoma valve implantation in patients with glaucoma secondary to iridocorneal endothelial syndrome.

Eye (Lond) 2020 May 4. Epub 2020 May 4.

State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangzhou, PR China.

Objectives: To evaluate the long-term outcome of patients with iridocorneal endothelial (ICE) syndrome who underwent Ahmed glaucoma valve implantation surgery for uncontrolled glaucoma.

Methods: Eighteen patients who suffered from unilateral ICE syndrome with uncontrolled glaucoma and subsequently underwent Ahmed aqueous shunt surgery at Zhongshan Ophthalmic Center between January 2008 and December 2016 were reviewed. Outcome measures included intraocular pressure (IOP), the use of glaucoma medications, visual acuity, further surgical interventions, and surgical complications. Read More

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http://dx.doi.org/10.1038/s41433-020-0912-2DOI Listing

Optical Coherence Tomography Angiography of Perilimbal Vasculature in Port-Wine Stain and Sturge-Weber Syndrome Patients.

Invest Ophthalmol Vis Sci 2020 Apr;61(4):43

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Purpose: To evaluate episcleral vasculature in corneal limbus with optical coherence tomography angiography (OCTA) in normal controls, port-wine stain (PWS) patients, and Sturge-Weber syndrome (SWS) patients.

Methods: Unilateral eyes from 18 normal controls (25.41 ± 4. Read More

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http://dx.doi.org/10.1167/iovs.61.4.43DOI Listing
April 2020
3.404 Impact Factor

Globe Axial Length Growth at Age 10.5 Years in the Infant Aphakia Treatment Study.

Am J Ophthalmol 2020 Apr 15. Epub 2020 Apr 15.

Department of Ophthalmology, Stanford University School of Medicine, Stanford, CA.

Purpose: To report the change in globe axial length (AL) from the time of unilateral cataract surgery at age 1-7 months to age 10.5 years for infants enrolled in the Infant Aphakia Treatment Study, and to compare AL growth of operated eyes with that of fellow unoperated eyes.

Design: Comparative case series. Read More

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http://dx.doi.org/10.1016/j.ajo.2020.04.010DOI Listing

Clinical Assessment of Scleral Canal Area in Glaucoma Using Spectral Domain Optical Coherence Tomography.

Am J Ophthalmol 2020 Apr 9. Epub 2020 Apr 9.

Department of Ophthalmology, Akita University Graduate School of Medicine, Akita, Japan.

Purpose: To investigate anterior scleral canal (ASC) area in the eyes with glaucoma using spectral-domain optical coherence tomography (SD-OCT).

Design: Cross-sectional study.

Methods: This study included 206 eyes of 103 patients with glaucoma classified as 66 eyes of 33 patients with unilateral glaucoma and 140 eyes of 70 patients with bilateral glaucoma. Read More

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http://dx.doi.org/10.1016/j.ajo.2020.03.043DOI Listing

The Swedish National Pediatric Cataract Register (PECARE): incidence and onset of postoperative glaucoma.

Acta Ophthalmol 2020 Apr 9. Epub 2020 Apr 9.

Department of Ophthalmology, Region Västra Götaland, Sahlgrenska University Hospital, Mölndal, Sweden.

Purpose: The aim was to report cumulative incidence and time of onset of postoperative glaucoma in a paediatric early cataract surgery cohort.

Methods: Data were retrieved from the Pediatric Cataract Register (PECARE), a prospective register of Swedish cataract operations before 8 years of age. All eyes with surgery between January 2007 and December 2014 and a registered follow-up were included. Read More

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http://dx.doi.org/10.1111/aos.14414DOI Listing

Bilateral morphometric analysis of corneal sub-basal nerve plexus in patients undergoing unilateral cataract surgery: a preliminary in vivo confocal microscopy study.

Br J Ophthalmol 2020 Apr 3. Epub 2020 Apr 3.

Department of Neuroscience Rehabilitation Ophthalmology Genetics and Maternal and Child Health Genova, University of Genoa, Genova, Italy.

Aims: To evaluate bilateral morphometric changes of corneal sub-basal nerve plexus (CSNP) occurring after unilateral cataract surgery by in vivo confocal microscopy (IVCM) images analysed with automated software.

Methods: IVCM was performed before (V0) and 1 month after surgery (V1) in both operated eyes (OEs) and unoperated eyes (UEs) of 30 patients. Thirty age and sex-matched subjects acted as controls. Read More

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http://dx.doi.org/10.1136/bjophthalmol-2019-315449DOI Listing

[Spatial contrast sensitivity in patients with primary open-angle glaucoma and ocular hypertension].

Vestn Oftalmol 2020 ;136(1):25-35

Chelyabinsk Regional Clinical Hospital No. 3, 287 Pobedy av., Chelyabinsk, Russian Federation, 454021.

Up to now, there has not been a comparison of spatial contrast sensitivity (SCS) in patients with primary and pseudoexfoliation open-angle glaucoma (POAG; PEG) and ophthalmic hypertension (OH).

Purpose: To study the characteristics of SCS in patients with POAG, PEG (as well as in the paired eye without glaucoma) and OH.

Material And Methods: The work was performed in the period from 2011 to July 2017. Read More

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http://dx.doi.org/10.17116/oftalma202013601125DOI Listing

Incidence of Sturge-Weber syndrome and associated ocular involvement in Olmsted County, Minnesota, United States.

Ophthalmic Genet 2020 Apr 31;41(2):108-124. Epub 2020 Mar 31.

Department of Ophthalmology, Mayo Clinic, Rochester, Minnesota, USA.

: Sturge-Weber syndrome (SWS) is a rare sporadic syndrome characterized by nevus flammeus (port-wine stain, PWS) in the trigeminal nerve distribution, diffuse choroidal hemangioma, and brain leptomeningeal hemangioma. We are unaware of previous reports of SWS incidence in the United States. This study investigated SWS incidence and associated ocular involvement in Olmsted County, Minnesota. Read More

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http://dx.doi.org/10.1080/13816810.2020.1731834DOI Listing

Glaucoma as the presenting sign of intraocular tumors: beware of the masquerading sign.

Int Ophthalmol 2020 Mar 20. Epub 2020 Mar 20.

Ophthalmic Plastic Surgery and Ocular Oncology Services, The Operation Eyesight Universal Institute for Eye Cancer, LV Prasad Eye Institute, Hyderabad, 500034, India.

Purpose: To discuss the clinical presentation and management of intraocular tumors masquerading as primary glaucoma or non-tumor-related secondary glaucoma.

Methods: Retrospective chart review.

Results: Ten patients with unsuspected intraocular tumor were referred to glaucoma clinic with a diagnosis of primary glaucoma or non-tumor-related secondary glaucoma. Read More

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http://dx.doi.org/10.1007/s10792-020-01348-xDOI Listing

Time course of bilateral microglial activation in a mouse model of laser-induced glaucoma.

Sci Rep 2020 Mar 17;10(1):4890. Epub 2020 Mar 17.

Instituto de Investigaciones Oftalmológicas Ramón Castroviejo, Universidad Complutense de Madrid, Madrid, Spain.

Microglial activation is associated with glaucoma. In the model of unilateral laser-induced ocular hypertension (OHT), the time point at which the inflammatory process peaks remains unknown. Different time points (1, 3, 5, 8, and 15 d) were compared to analyze signs of microglial activation both in OHT and contralateral eyes. Read More

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http://dx.doi.org/10.1038/s41598-020-61848-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7078298PMC

The worse eye revisited: Evaluating the impact of asymmetric peripheral vision loss on everyday function.

Vision Res 2020 Apr 14;169:49-57. Epub 2020 Mar 14.

Institute of Ophthalmology, University College London (UCL), London, United Kingdom; National Institute for Health Research Moorfields Biomedical Research Centre, London, United Kingdom. Electronic address:

In instances of asymmetric peripheral vision loss (e.g., glaucoma), binocular performance on simple psychophysical tasks (e. Read More

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http://dx.doi.org/10.1016/j.visres.2019.10.012DOI Listing

Focal lamina cribrosa defects and significant peripapillary choroidal thinning in patients with unilateral branch retinal vein occlusion.

PLoS One 2020 12;15(3):e0230293. Epub 2020 Mar 12.

Department of Ophthalmology, Yonsei University College of Medicine, Seoul, Republic of Korea.

Purpose: To investigate the prevalence of focal lamina cribrosa (LC) defects in patients with unilateral branch retinal vein occlusion (BRVO) and to compare ocular characteristics between eyes with and without focal LC defect and those eyes with normal-tension glaucoma (NTG).

Methods: This retrospective, cross-sectional study included 121 patients. Thirty-nine patients had unilateral BRVO (BRVO group), 36 patients had NTG (NTG group), and 36 patients had vitreous floaters, but no other ocular diseases (control group). Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0230293PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7067421PMC
March 2020
3.234 Impact Factor

Unilateral acute iris depigmentation and transillumination after glaucoma surgery with mitomycin application and intracameral moxifloxacin.

Am J Ophthalmol Case Rep 2020 Jun 27;18:100639. Epub 2020 Feb 27.

Clínica Rementería, Madrid, Spain.

Purpose: Bilateral acute iris depigmentation (BADI) and transillumination (BATI) syndromes have been linked with the use of antibiotics, especially fluoroquinolones. They are characterized by acute onset of pigment dispersion in the anterior chamber, depigmentation of the iris and pigment deposition in the angle and in the posterior surface of the cornea (BADI), with iris transillumination defects and atonic pupil with sphincter paralysis (BATI). The purpose of this paper is to report the development of clinical depigmentation and iris damage similar to BADI and BATI in patients who had undergone uneventful glaucoma surgery with intracameral moxifloxacin as prophylaxis for endophthalmitis. Read More

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http://dx.doi.org/10.1016/j.ajoc.2020.100639DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7057145PMC

Diurnal Cycle of Translaminar Pressure in Nonhuman Primates Quantified With Continuous Wireless Telemetry.

Invest Ophthalmol Vis Sci 2020 02;61(2):37

Purpose: Recent retrospective clinical studies and animal experiments have suggested that cerebrospinal fluid pressure (CSFP) is important in glaucoma pathogenesis. Intraocular pressure (IOP) and CSFP are the driving components of the translaminar pressure (TLP), which directly effects the optic nerve head. This study measured the diurnal cycle of TLP using continuous wireless telemetry in nonhuman primates (NHPs), a common animal model of glaucoma. Read More

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http://dx.doi.org/10.1167/iovs.61.2.37DOI Listing
February 2020

Combined intra-arterial chemotherapy and intravitreal melphalan for the treatment of advanced unilateral retinoblastoma.

Int J Ophthalmol 2020 18;13(2):257-262. Epub 2020 Feb 18.

Department of Ophthalmology, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China.

Aim: To evaluate the efficacy and safety of combined intra-arterial chemotherapy (IAC) and intravitreal melphalan (IVM) for the treatment of advanced unilateral retinoblastoma.

Methods: This retrospective study involved 30 consecutive eyes from 30 Chinese patients with advanced unilateral retinoblastoma. All patients were initially treated with IAC combined with IVM. Read More

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http://dx.doi.org/10.18240/ijo.2020.02.09DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7013797PMC
February 2020

Significant correlations between photopic negative response, afferent pupillary defect, and mean defects of visual fields in asymmetric optic nerve disorders.

Graefes Arch Clin Exp Ophthalmol 2020 Feb 21. Epub 2020 Feb 21.

Department of Opthalmology, Osaka Medical College, 2-7 Daigaku-machi, Takatsuki, Osaka, 569-8686, Japan.

Purpose: The photopic negative response (PhNR) is a negative wave following the b-wave of the photopic electroretinogram (ERG). The PhNR originates from the retinal ganglion cells (RGCs), and it can be used to assess the function of RGCs noninvasively and objectively. The purpose of this study was to determine whether the relative amplitudes (affected/normal eye) of the PhNR are significantly correlated with the degree of the relative afferent pupillary defect (RAPD) in eyes with unilateral or asymmetrical damage of the optic nerve. Read More

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http://dx.doi.org/10.1007/s00417-020-04632-9DOI Listing
February 2020

Choroidal neovascular membrane associated with primary congenital glaucoma and buphthalmos.

J AAPOS 2020 Feb 25;24(1):53-56. Epub 2020 Feb 25.

Bascom Palmer Eye Institute, Miami, Florida. Electronic address:

An 18-year-old man with primary congenital glaucoma and buphthalmos in both eyes presented with unilateral, sudden-onset, painless vision loss. He had previously undergone multiple sectoral ab externo rigid-probe trabeculotomy in both eyes and subsequently Baervelt glaucoma implantion in both eyes, with adequate intraocular pressure control. Examination revealed subfoveal choroidal neovascular membrane (CNVM) and associated hemorrhages in the right eye. Read More

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http://dx.doi.org/10.1016/j.jaapos.2019.11.012DOI Listing
February 2020

Prostaglandin analogues: A double-edged sword in orbital glaucoma disease management.

Eur J Ophthalmol 2020 Feb 11:1120672120905296. Epub 2020 Feb 11.

Department of Glaucoma Surgery, Manchester Royal Eye Hospital, Manchester, UK.

Introduction: The authors describe benefits of the recognised adverse effects of prostaglandin analogues on periocular structures in patients with unilateral proptosis and intraocular pressure rise. This case points to intentional consideration of prostaglandin analogue therapy in this selected cohort of patients with secondary ocular hypertension and proptosis.

Case Description: A 70-year-old gentleman who presented with a 1-week history of a red and painful right eye associated with tortuous and dilated episcleral blood vessels. Read More

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http://dx.doi.org/10.1177/1120672120905296DOI Listing
February 2020

CHARGE Syndrome Associated with Angle Closure despite High Myopia: A Case Report with Structural Suggestion.

Case Rep Ophthalmol 2020 Jan-Apr;11(1):28-36. Epub 2020 Jan 9.

Department of Ophthalmology and Visual Science, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan.

CHARGE syndrome is associated with multiple malformations, and the main ocular abnormality is coloboma. We describe an unusual case of a 15-year-old girl with CHARGE syndrome having high intraocular pressure and narrow angle closure despite refractive high myopia (-9.0 dpt) in her left eye. Read More

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http://dx.doi.org/10.1159/000505389DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6984150PMC
January 2020

Clinical findings of traumatic proptosis in small-breed dogs and complications associated with globe replacement surgery.

Open Vet J 2019 10 4;9(3):222-229. Epub 2019 Aug 4.

Department of Small Animal Surgery and Ophthalmology, Faculty of Veterinary Medicine, Cairo University, Cairo, Egypt.

Background: Proptosis is a serious traumatic disease commonly affecting small breed dogs and possibly causing loss of vision, with globe replacement surgery (GRS) being essential in most of the cases after stabilizing the patient's condition.

Aim: To determine the common dog breeds and clinical findings associated with traumatic proptosis and demonstrate the short-term complications following GRS.

Methods: The study was performed on 15 client-owned small-breed dogs presented with unilateral traumatic proptosis. Read More

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http://dx.doi.org/10.4314/ovj.v9i3.6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6794399PMC
October 2019

Peripapillary Vessel Density In Unilateral Preperimetric Glaucoma.

Clin Ophthalmol 2019 13;13:2511-2519. Epub 2019 Dec 13.

1st University Eye Clinic, General Hospital "G. Gennimatas", Athens, Greece.

Purpose: To investigate vessel density (VD) of radial peripapillary capillaries (RPC) and structural alterations in patients with unilateral preperimetric glaucoma (PPG) using optical coherence tomography angiography (OCTA).

Methods: This cross-sectional observational study included 13 untreated patients with unilateral PPG. PPG eyes had larger excavation and abnormal thinning of retinal nerve fiber layer (RNFL) and/or ganglion cell complex (GCC) compared with fellow eyes (F). Read More

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http://dx.doi.org/10.2147/OPTH.S224757DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6917599PMC
December 2019

Outcomes of Bilateral Cataracts Removed in Infants 1 to 7 Months of Age Using the Toddler Aphakia and Pseudophakia Treatment Study Registry.

Ophthalmology 2020 Apr 9;127(4):501-510. Epub 2019 Nov 9.

Department of Ophthalmology, Emory University School of Medicine, Atlanta, Georgia; Departments of Ophthalmology and Pediatrics, Stanford University School of Medicine, Palo Alto, California.

Purpose: To evaluate outcomes of bilateral cataract surgery in infants 1 to 7 months of age performed by Infant Aphakia Treatment Study (IATS) investigators during IATS recruitment and to compare them with IATS unilateral outcomes.

Design: Retrospective case series review at 10 IATS sites.

Participants: The Toddler Aphakia and Pseudophakia Study (TAPS) is a registry of children treated by surgeons who participated in the IATS. Read More

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http://dx.doi.org/10.1016/j.ophtha.2019.10.039DOI Listing

Elevated Intraocular Pressure Causes Abnormal Reactivity of Mouse Retinal Arterioles.

Oxid Med Cell Longev 2019 29;2019:9736047. Epub 2019 Dec 29.

Department of Ophthalmology, University Medical Center, Johannes Gutenberg University Mainz, Langenbeckstr. 1, 55131 Mainz, Germany.

Objective: Glaucoma is a leading cause of severe visual impairment and blindness. Although high intraocular pressure (IOP) is an established risk factor for the disease, the role of abnormal ocular vessel function in the pathophysiology of glaucoma gains more and more attention. We tested the hypothesis that elevated intraocular pressure (IOP) causes vascular dysfunction in the retina. Read More

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http://dx.doi.org/10.1155/2019/9736047DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6954472PMC
December 2019

Solitary Free-Floating Iris Cyst Associated With Bilateral Pigment Dispersion Syndrome: Report of a Case.

J Glaucoma 2020 Mar;29(3):239-240

Department of Surgical & Clinical, Diagnostic and Pediatric Sciences, Section of Ophthalmology, University of Pavia-IRCCS Fondazione Policlinico San Matteo, Pavia.

Case Report: A 27-year-old white man with a 5-year history of pigment dispersion syndrome presented for evaluation. His past ocular history was significant for bilateral intraocular pressure elevation that had required intraocular pressure -lowering medication (beta-blocker-prostaglandin analogue fixed combination). On ophthalmic examination, the visual acuity was 20/20 without correction in both eyes. Read More

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http://dx.doi.org/10.1097/IJG.0000000000001444DOI Listing

Simultaneous bilateral pediatric and juvenile cataract surgery under general anesthesia: outcomes and safety.

Am J Ophthalmol 2020 Jan 13. Epub 2020 Jan 13.

Department of Ophthalmology, Medical University of Vienna, MUW.

Purpose: The purpose of the study was to evaluate the surgical approach, outcome and safety of bilateral simultaneous cataract surgery (BS-Cat) compared with unilateral cataract surgery (US-Cat) and bilateral two-timed cataract surgery (BT-Cat) in children.

Design: retrospective, interventional case series METHODS: Setting: Department of Ophthalmology, Medical University, Vienna,Participants: Children aged 0 to 18 years who received cataract extraction due to a uni- or bilateral cataract between January 2003 and December 2018 were included. Main outcomes and measures: Information regarding the type and duration of surgery, and total anesthesia time were recorded. Read More

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http://dx.doi.org/10.1016/j.ajo.2020.01.001DOI Listing
January 2020

Congenital corneal blood staining secondary to hemorrhagic persistent fetal vasculature.

J AAPOS 2020 Feb 11;24(1):51-53. Epub 2020 Jan 11.

Department of Ophthalmology, Icahn School of Medicine at Mount Sinai, New York, New York.

An African American girl born at 37 weeks via spontaneous vaginal delivery to a 33-year-old woman was noted on delivery to have a unilateral absent red reflex in the right eye, which was enlarged. Intraocular pressure was elevated, and the cornea had a straw-colored opacity. B-scan ultrasonography of the right eye showed diffuse hyperechoic vitreous opacities and a retrolental mass, with a hyperechoic band stretching from the optic disk to the posterior lens. Read More

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http://dx.doi.org/10.1016/j.jaapos.2019.11.007DOI Listing
February 2020

Incidence of Glaucoma or Ocular Hypertension After Repeated Anti-Vascular Endothelial Growth Factor Injections for Macular Degeneration.

Clin Ophthalmol 2019 24;13:2563-2572. Epub 2019 Dec 24.

Wheaton Eye Clinic, Wheaton, IL 60187, USA.

Purpose: To estimate the risk of glaucoma or sustained ocular hypertension (OHT) related to anti-vascular endothelial growth factor (VEGF) injections for age-related macular degeneration (AMD).

Design: Retrospective chart review.

Subjects: Patients who received unilateral anti-VEGF injections for AMD at the Wheaton Eye Clinic (IL). Read More

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http://dx.doi.org/10.2147/OPTH.S232548DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6935302PMC
December 2019

Measurement of Retinal Changes in Primary Acute Angle Closure Glaucoma under Different Durations of Symptoms.

J Ophthalmol 2019 4;2019:5409837. Epub 2019 Dec 4.

Department of Ophthalmology, Zhongnan Hospital of Wuhan University, Wuhan, China.

Purpose: To investigate the changes of retinal nerve fiber layer (RNFL) in patients after an attack of primary acute angle closure glaucoma (PAACG) and to assess the impact of attack time on prognosis of retinal changes.

Design: cross-sectional study.

Methods: Twenty-six patients with unilateral PAACG attack and cataracts from 2017 to 2019 were enrolled. Read More

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http://dx.doi.org/10.1155/2019/5409837DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6914934PMC
December 2019

Relationship between optic disc hemorrhage and corneal hysteresis.

Can J Ophthalmol 2019 Dec 23. Epub 2019 Dec 23.

Einhorn Clinical Research Center, New York Eye and Ear Infirmary, New York, NY.

Objective: To determine the relationship between optic disc hemorrhage (DH) and corneal hysteresis (CH).

Methods: Consecutive patients with prior or current photographic evidence of unilateral DH who had undergone CH measurement with the Ocular Response Analyzer (ORA; Reichert, Buffalo, NY) were enrolled. Eyes with a history of corneal disease, refractive surgery, or bilateral DH were excluded. Read More

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http://dx.doi.org/10.1016/j.jcjo.2019.10.007DOI Listing
December 2019

Long-term functional outcomes of different subtypes of primary congenital glaucoma.

Br J Ophthalmol 2019 Dec 23. Epub 2019 Dec 23.

Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All india Institute of Medical Sciences, New Delhi, India

Aim: To analyse long-term visual outcomes across different subtypes of primary congenital glaucoma (PCG).

Methods: Patients with PCG with a minimum of 5-year follow-up post surgery were included in the study. Snellen visual acuity recordings taken at their last follow-up were analysed. Read More

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http://dx.doi.org/10.1136/bjophthalmol-2019-315131DOI Listing
December 2019
2.976 Impact Factor

Thickness of the Lamina Cribrosa, Retinal Nerve Fiber Layer, and Peripapillary Choroid in Patients with Branch Retinal Vein Occlusion.

Ophthalmologica 2019 Nov 29. Epub 2019 Nov 29.

Purpose: To compare the thickness of the lamina cribrosa (LC), retinal nerve fiber layer (RNFL), and peripapillary choroid (PC) in patients with unilateral branch retinal vein occlusion (BRVO) and in healthy individuals.

Methods: The 70 eyes of 35 patients with unilateral BRVO, grouped as either affected or unaffected, and 38 right eyes of 38 healthy individuals were examined for LC, RNFL, and PC thickness and LC depth with spectral-domain optical coherence tomography.

Results: The unaffected eyes of patients with BRVO had significantly thinner RNFLs on average and in the inferior quadrant than the eyes of healthy controls. Read More

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http://dx.doi.org/10.1159/000505100DOI Listing
November 2019

Iridocorneal Angle and Anterior Segment Structure of Eyes in Children with Cataract.

Ophthalmic Res 2020 26;63(2):194-202. Epub 2019 Nov 26.

School of Optometry and Ophthalmology, Wenzhou Medical University, Wenzhou, China,

Objective: To evaluate the morphology of iridocorneal angle and anterior segment in eyes of children with cataract.

Methods: In this prospective cross-sectional study, we included eyes of children with bilateral cataract as well as unilateral cataract and fellow eyes. The iridocorneal angle was evaluated using gonioscopy. Read More

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http://dx.doi.org/10.1159/000505002DOI Listing
November 2019

Cost-Utility Analysis of Glaucoma Medication Adherence.

Ophthalmology 2020 May 10;127(5):589-598. Epub 2019 Oct 10.

Department of Clinical Pharmacy and Translational Science, College of Pharmacy, University of Tennessee Health Science Center, Nashville, Tennessee.

Purpose: The majority of patients with glaucoma do not take their medications as prescribed. Estimates of the cost-utility value of adherence to prescribed glaucoma medication are vital to implement potentially effective interventions.

Design: Cost-utility analysis using Monte Carlo microsimulations incorporating a series of Markov cycles (10 000 iterations per strategy). Read More

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http://dx.doi.org/10.1016/j.ophtha.2019.09.041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7145750PMC

Incidence and Management of Glaucoma or Glaucoma Suspect in the First Year After Pediatric Lensectomy.

JAMA Ophthalmol 2019 Nov 21. Epub 2019 Nov 21.

Flaum Eye Institute, University of Rochester Medical Center, Rochester, New York.

Importance: Glaucoma can occur following cataract removal in children, and determining the risk for and factors associated with glaucoma and glaucoma suspect in a large cohort of children after lensectomy can guide clinical practice.

Objective: To estimate the incidence of glaucoma and glaucoma suspect and describe its management in the first year following lensectomy in children before 13 years of age.

Design, Setting, And Participants: A multicenter clinical research registry containing data for 1361 eyes of 994 children who underwent unilateral or bilateral lensectomy between June 2012 and July 2015 at 1 of 61 sites in the United States (n = 57), Canada (n = 3), and the United Kingdom (n = 1). Read More

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http://dx.doi.org/10.1001/jamaophthalmol.2019.4571DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6902171PMC
November 2019

Decoding PERG: A neuro-ophthalmic retinal ganglion cell function review.

Authors:
Pedro Monsalve

Curr Ophthalmol Rep 2019 Mar 13;7(1):51-58. Epub 2019 Feb 13.

Bascom Palmer Eye Institute, Department of Ophthalmology, University of Miami Miller School of Medicine, 900 NW 17 Street, Miami, FL, 33136.

Purpose Of Review: Currently, the clinical evaluation of neuro-ophthalmologic diseases are mainly focused on identifying stages where structural or functional damage occur. Recognition of retinal ganglion cell (RGC) functional patterns as well as monitoring RGC dysfunction can be performed using steady-state pattern electroretinogram (PERG). The analysis of the amplitude and latency shift aid on providing information on early damage or monitoring of the RGC, allowing for prompt clinical intervention and management modification, potentially changing the natural history of the disease. Read More

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http://dx.doi.org/10.1007/s40135-019-00199-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6857793PMC

Iridocorneal endothelial syndrome in a patient with keratoconus - a case report.

BMC Ophthalmol 2019 Nov 11;19(1):221. Epub 2019 Nov 11.

Ophthalmology Unit, AUSL-IRCCS of Reggio Emilia, Reggio Emilia, Italy.

Background: To describe a case of a rare association of bilateral keratoconus and unilateral essential iris atrophy and to conduct a literature review of the current strategies of treatment of the corneal disease and glaucoma in patients with Iridocorneal Endothelial Syndrome (ICE).

Case Presentation: We report a rare association of bilateral keratoconus and unilateral essential iris atrophy in a 38-year-old man. Diagnosis of bilateral keratoconus was confirmed by corneal topography. Read More

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http://dx.doi.org/10.1186/s12886-019-1215-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6849214PMC
November 2019

Vessel density and retinal nerve fibre layer thickness following acute primary angle closure.

Br J Ophthalmol 2019 Nov 1. Epub 2019 Nov 1.

The Viterbi Family Department of Ophthalmology/Shiley Eye Institute, University of California San Diego, La Jolla, California, USA

Background: To evaluate changes in circumpapillary vessel density (cpVD) and retinal nerve fibre layer (cpRNFL) thickness after a successfully treated episode of acute primary angle closure (APAC) and to identify factors associated with glaucoma progression in these eyes.

Methods: Twenty-six patients successfully treated for a unilateral episode of APAC were included in this prospective study. Optical coherence tomography (OCT) cpRNFL thickness and OCT angiography (OCTA) cpVD were compared between 2 and 8 months after treatment. Read More

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http://dx.doi.org/10.1136/bjophthalmol-2019-314789DOI Listing
November 2019

Primary congenital glaucoma in Denmark, 1977-2016.

Acta Ophthalmol 2020 Mar 30;98(2):182-189. Epub 2019 Oct 30.

Department of Ophthalmology, University Hospital of Copenhagen, Rigshospitalet-Glostrup, Glostrup, Denmark.

Purpose: To perform an epidemiological survey of all patients in Denmark diagnosed with primary congenital glaucoma (PCG) from 1977 to 2016.

Methods: A retrospective, nationwide study based on a review of medical files of all children with PCG born in Denmark from 1977 to 2016. PCG was defined as glaucoma due to isolated angle dysgenesis affecting children from birth and including late onset/late recognized PCG, excluding glaucoma associated with other congenital abnormalities. Read More

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http://dx.doi.org/10.1111/aos.14207DOI Listing

Glaucoma in Ectropion Uveae Syndrome: A Case Report and Literature Review.

J Ophthalmic Vis Res 2019 Jul-Sep;14(3):370-375. Epub 2019 Jul 18.

Ophthalmic Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Purpose: To report a case of advanced childhood glaucoma secondary to congenital ectropion uveae (CEU).

Case Report: The patient was a seven-year-old boy with unilateral glaucoma secondary to CEU and facial asymmetry, mild unilateral ptosis, and proptosis in the left eye. The intraocular pressure (IOP) was 28 mmHg and cup-to-disc ratio was 0. Read More

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http://dx.doi.org/10.18502/jovr.v14i3.4793DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6815341PMC

Effects of Intravitreal Anti-VEGF Therapy on Glaucoma-like Progression in Susceptible Eyes.

J Glaucoma 2019 Dec;28(12):1035-1040

Department of Ophthalmology, University of Virginia, Charlottesville, VA.

PRéCIS:: Intravitreal anti-vascular endothelial growth factor (VEGF) injections may accelerate glaucomatous change in patients with preexisting glaucoma or ocular hypertension (OHT). The safety of long-term injections in this specific population may be reflected in the need for additional glaucoma interventions.

Purpose: The purpose of this study was to investigate whether repeated anti-VEGF injections accelerate structural and functional glaucomatous change in eyes with preexisting glaucoma or OHT. Read More

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http://dx.doi.org/10.1097/IJG.0000000000001382DOI Listing
December 2019
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Long-term visual and anatomic outcomes following early surgery for persistent fetal vasculature: a single-center, 20-year review.

J AAPOS 2019 12 17;23(6):327.e1-327.e5. Epub 2019 Oct 17.

Department of Ophthalmology and Vision Sciences, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada; Department of Ophthalmology and Vision Sciences, University of Toronto, Toronto, Ontario, Canada. Electronic address:

Background: Persistent fetal vasculature (PFV) is a spectrum of congenital anomalies caused by complete or partial failure of the ocular fetal vasculature to regress. We report the visual and anatomic outcomes in a large cohort of patients who underwent early surgery for PFV.

Methods: We retrospectively reviewed the medical records of patients who underwent lensectomy and anterior or core vitrectomy for unilateral PFV without primary intraocular lens implantation through limbal or pars plana/plicata approach. Read More

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http://dx.doi.org/10.1016/j.jaapos.2019.07.009DOI Listing
December 2019
1 Read

A literature review on Fuchs uveitis syndrome: An update.

Surv Ophthalmol 2020 Mar - Apr;65(2):133-143. Epub 2019 Oct 14.

Department of Ophthalmology, Eye & ENT Hospital of Fudan University, Shanghai, China; Eye Institute, Eye & ENT Hospital of Fudan University, Shanghai, China; National Health Commission (NHC) Key Laboratory of Myopia (Fudan University), Shanghai, China; Laboratory of Myopia, Chinese Academy of Medical Sciences, Shanghai, China; Key Laboratory of Visual Impairment and Restoration of Shanghai, Shanghai, China. Electronic address:

Fuchs uveitis syndrome is a chronic, typically unilateral, ocular condition characterized by an asymptomatic mild inflammatory syndrome that can result in cataract and secondary glaucoma. Diagnosis is largely clinical because the etiology remains obscure. Fuchs uveitis syndrome is most likely the result of different insults or pathogenic mechanisms, including infections, autoimmune diseases, hereditary and sympathetic dysfunction. Read More

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http://dx.doi.org/10.1016/j.survophthal.2019.10.003DOI Listing
October 2019
1 Read

Unilateral Malignant Glaucoma Postbilateral Implantable Collamer Lens: Effect of Miotics.

Middle East Afr J Ophthalmol 2019 Jul-Sep;26(3):181-183. Epub 2019 Sep 30.

Department of Cornea and Refractive Surgery, Beirut Eye and ENT Specialist Hospital, Beirut, Lebanon.

An implantable collamer lens (ICL) V4c model (STAAR Surgical, Monrovia, CA, USA) was placed in the eye of a 31-year-old male patient with high myopia followed by the development of malignant glaucoma. After failing medical treatment for 5 days, a noncomplicated pars plana vitrectomy and anterior hyaloidectomy succeeded in breaking the aqueous misdirection. Sixteen months later, intraoperative miotics were purposefully withheld from the ICL surgery in the fellow eye and malignant glaucoma did not develop. Read More

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http://dx.doi.org/10.4103/meajo.MEAJO_197_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6788314PMC
January 2020
1 Read

The Relationship Between Scleral Strain Change and Differential Cumulative Intraocular Pressure Exposure in the Nonhuman Primate Chronic Ocular Hypertension Model.

Invest Ophthalmol Vis Sci 2019 10;60(13):4141-4150

Department of Ophthalmology, University of Alabama at Birmingham, Birmingham, Alabama, United States.

Purpose: To determine the relationship between peripapillary scleral strain change and cumulative differential IOP exposure in nonhuman primates (NHPs) with unilateral chronic ocular hypertension.

Methods: Posterior scleral shells from 6 bilaterally normal and 10 unilateral chronic ocular hypertension NHPs were pressurized from 5 to 45 mm Hg, and the resulting full-field, three-dimensional, scleral surface deformations were acquired using laser speckle interferometry. Scleral tensile strain (local tissue deformation) was calculated by analytical differentiation of the displacement field; zero strain was assumed at 5 mm Hg. Read More

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http://dx.doi.org/10.1167/iovs.19-27060DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6785842PMC
October 2019
1 Read

Retinal and Choroidal Vascular Changes in Eyes with Pseudoexfoliation Syndrome: A Comparative Study Using Optical Coherence Tomography Angiography

Balkan Med J 2019 12 9;37(1):9-14. Epub 2019 Oct 9.

Clinic of Ophthalmology, Alaaddin Keykubat University Training and Research Hospital, Alanya, Antalya, Turkey

Background: Optical coherence tomography angiography allows a detailed evaluation of retinal and choroidal microvascular structures without the need for a contrast agent. Pseudoexfoliation syndrome is a condition that leads to anatomical and functional losses due to accumulation of degraded abnormal fibrillar material in the intraocular and extraocular tissues. Histopathological studies have shown that the accumulation of Pseudoexfoliation syndrome material in the vascular structures may play a role in different ocular pathologies such as retinal vein occlusion, iris hypoperfusion, anterior segment hypoxia, retinal arterial occlusion, and neovascular glaucoma. Read More

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http://dx.doi.org/10.4274/balkanmedj.galenos.2019.2019.5.5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6934010PMC
December 2019

Glaucoma following cataract surgery in the first 2 years of life: frequency, risk factors and outcomes from IoLunder2.

Br J Ophthalmol 2019 Oct 5. Epub 2019 Oct 5.

National Institute for Health Research Biomedical Research Centre, UCL Great Ormond Street Institute of Child Health and Great Ormond Street Hospital, London, UK

Background: We investigated glaucoma related adverse events, predictors and impact at 5 years following surgery in the IoLunder2 cohort METHODS: Population based observational cohort study of children undergoing cataract surgery aged 2 years or under between January 2009 and December 2010. Glaucoma was defined using internationally accepted taxonomies based on the consequences of elevated intraocular pressure (IOP). Glaucoma related adverse events were any involving elevated IOP. Read More

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http://dx.doi.org/10.1136/bjophthalmol-2019-314804DOI Listing
October 2019
1 Read

Clinical, ultrasonographic, and histopathologic findings in seven horses with Descemet's membrane detachment: A case series.

Vet Ophthalmol 2020 Jan 22;23(1):181-189. Epub 2019 Sep 22.

Faculty of Veterinary Medicine, Department of Clinical Sciences of Companion Animals, Ophthalmology Section, Utrecht University, Utrecht, The Netherlands.

Objective: To describe ultrasonography as a diagnostic method of in vivo Descemet's membrane detachment (DMD) in horses.

Animals Studied: Seven horses (three Icelandic horses, two Dutch Warmblood horses, one Appaloosa, and one Welsh Pony), presenting with moderate-to-severe focal or diffuse corneal edema, in whom DMD was suspected on ultrasonographic examination and confirmed with histopathology, were studied.

Procedure: A retrospective analysis of case records of horses with suspected DMD was performed. Read More

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http://dx.doi.org/10.1111/vop.12710DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7003845PMC
January 2020
3 Reads

Traumatic Cataracts in Children, Long-Term Follow-up in an Israeli Population: A Retrospective Study.

Isr Med Assoc J 2019 Sep;21(9):599-602

Department of Ophthalmology, Kaplan Medical Center, Rehovot, Israel.

Background: Ocular trauma in the pediatric population may lead to cataract formation. Managing traumatic cataracts in a visually immature child is a major challenge and can result in poor visual outcome.

Objectives: To review our long-term surgical experience with childhood unilateral traumatic cataracts. Read More

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September 2019
2 Reads
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