67,720 results match your criteria Glaucoma Today [Journal]


Functional Fungal Endophytes in Coleus forskohlii Regulate Labdane Diterpene Biosynthesis for Elevated Forskolin Accumulation in Roots.

Microb Ecol 2019 Apr 17. Epub 2019 Apr 17.

Microbial Technology Laboratory, CSIR- Central Institute of Medicinal and Aromatic Plants, Research Center, Bangalore, 560065, India.

Coleus forskohlii is a perennial medicinal shrub cultivated mainly for its forskolin content. The plant has been used since ancient times in ayurvedic traditional medicines for the treatment of hypertension, glaucoma, asthma, congestive heart failures, obesity, and cancer. Use of endophytic microorganisms presents a special interest for the development of value-added bioactive compounds through agriculture. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00248-019-01376-wDOI Listing

Elevated Plasma Levels of Drebrin in Glaucoma Patients With Neurodegeneration.

Front Neurosci 2019 3;13:326. Epub 2019 Apr 3.

State Key Laboratory of Ophthalmology, Optometry and Visual Science, The Eye Hospital of Wenzhou Medical University, Wenzhou, China.

Glaucoma is an optic neuropathy characterized by progressive degeneration of retinal ganglion cells (RGCs). Aberrations in several cytoskeletal proteins, such as tau have been implicated in the pathogenesis of neurodegenerative diseases, could be initiating factors in glaucoma progression and occurring prior to axon degeneration. Developmentally regulated brain protein (Drebrin or DBN1) is an evolutionarily conserved actin-binding protein playing a prominent role in neurons and is implicated in neurodegenerative diseases. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fnins.2019.00326DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456690PMC

Mutant RAMP2 causes primary open-angle glaucoma via the CRLR-cAMP axis.

Genet Med 2019 Apr 19. Epub 2019 Apr 19.

The Key Laboratory for Human Disease Gene Study of Sichuan Province and Department of Laboratory Medicine, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan, China.

Purpose: Primary open-angle glaucoma (POAG) is the leading cause of irreversible blindness worldwide and mutations in known genes can only explain 5-6% of POAG. This study was conducted to identify novel POAG-causing genes and explore the pathogenesis of this disease.

Methods: Exome sequencing was performed in a Han Chinese cohort comprising 398 sporadic cases with POAG and 2010 controls, followed by replication studies by Sanger sequencing. Read More

View Article

Download full-text PDF

Source
http://www.nature.com/articles/s41436-019-0507-0
Publisher Site
http://dx.doi.org/10.1038/s41436-019-0507-0DOI Listing
April 2019
1 Read

Aqueous shunts with mitomycin C versus aqueous shunts alone for glaucoma.

Cochrane Database Syst Rev 2019 Apr 19;4:CD011875. Epub 2019 Apr 19.

Ophthalmology, Singapore National Eye Centre, Singapore, Singapore.

Background: Glaucoma affects more than 70 million people worldwide, with about 10% being bilaterally blind, making it the leading cause of irreversible blindness globally. In patients with advanced glaucoma or those who have failed medical treatment without achieving adequate intraocular pressure (IOP) control, trabeculectomy (glaucoma filtration surgery where an ostium is created into the anterior chamber from underneath a partial thickness scleral flap to allow for aqueous flow out of the anterior chamber intointo the subconjunctival space forming a filtering bleb) and aqueous shunt surgery for more complex and refractory cases remain the mainstay therapies. Proliferation of fibrous tissue around an implanted aqueous shunt may block the diffusion of aqueous humour. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1002/14651858.CD011875.pub2
Publisher Site
http://dx.doi.org/10.1002/14651858.CD011875.pub2DOI Listing
April 2019
1 Read

Comparing Three Different Contrast Sensitivity Tests in Adults and in Children with and without Amblyopia.

Klin Monbl Augenheilkd 2019 Apr 18;236(4):434-437. Epub 2019 Apr 18.

University Eye Hospital Basel, Basel, Switzerland.

Background: Tests of contrast sensitivity (CS) are not routinely performed in the clinic, although CS is reduced in many conditions, such as amblyopia or glaucoma. This may be due to perceived time constraints or unaffordability of equipment.

Patients And Methods: Monocular CS functions obtained with the FACT, CSV 1000E, and Lea Symbols were compared in 19 healthy subjects aged 24 - 78 years and 24 subjects aged 5 - 16 years, 9 of whom had amblyopia. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1055/a-0853-1683DOI Listing

Retinal oximetry: Metabolic imaging for diseases of the retina and brain.

Prog Retin Eye Res 2019 Apr 15. Epub 2019 Apr 15.

University of Iceland, Reykjavik, Iceland.

Retinal oximetry imaging of retinal blood vessels measures oxygen saturation of hemoglobin. The imaging technology is non-invasive and reproducible with remarkably low variability on test-retest studies and in healthy cohorts. Pathophysiological principles and novel biomarkers in several retinal diseases have been discovered, as well as possible applications for systemic and brain disease. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.preteyeres.2019.04.001DOI Listing
April 2019
2 Reads

Therapeutic Window for Phosphodiesterase 6-Related Retinitis Pigmentosa.

JAMA Ophthalmol 2019 Apr 18. Epub 2019 Apr 18.

Jonas Children's Vision Care and Bernard & Shirlee Brown Glaucoma Laboratory, Departments of Ophthalmology and Pathology and Cell Biology, Columbia Stem Cell Initiative, Institute of Human Nutrition, Herbert Irving Comprehensive Cancer Center, Columbia University, New York, New York.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1001/jamaophthalmol.2018.6381DOI Listing

Artificial Intelligence and Optical Coherence Tomography Imaging.

Asia Pac J Ophthalmol (Phila) 2019 Apr 18. Epub 2019 Apr 18.

Harkness Eye Institute, Columbia University, New York, United States.

This review article aimed to highlight the application and use of artificial intelligence (AI) in optical coherence tomography (OCT) imaging in ophthalmology. Artificial intelligence programs seek to simulate intelligent human behavior in computers. With an abundance of patient data, especially with the advent and growing use of imaging modalities such as OCT, AI programs provide us with the unique opportunity to analyze this plethora of information and assist in making clinical decisions in the field of ophthalmology. Read More

View Article

Download full-text PDF

Source
http://www.apjo.org/Apjo/pdf/id/654.html
Publisher Site
http://dx.doi.org/10.22608/APO.201904DOI Listing
April 2019
1 Read

[Complications in sutured scleral fixation of artificial lens implantation].

Ophthalmologe 2019 Apr 17. Epub 2019 Apr 17.

Klinik für Augenheilkunde, Universitätsmedizin Göttingen, Göttingen, Deutschland.

Background: Sutured scleral fixation of an artificial posterior chamber lens is a frequently used method for the treatment of eyes with poor or absent capsular support; however, the complication profile is often considered unfavorable.

Objective: To analyze the postoperative complication profile.

Methods: In this monocentric and retrospective analysis of a consecutive case series of patients with standardized sutured scleral fixation of a posterior chamber lens between 2007 and 2017, the documented complications were categorized as a permanent threat to visual acuity, such as endophthalmitis, choroidal hemorrhage, retinal detachment and clinically relevant but without a permanent threat to visual acuity, such as hemorrhage and hypotension. Read More

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s00347-019-0896-0
Publisher Site
http://dx.doi.org/10.1007/s00347-019-0896-0DOI Listing
April 2019
1 Read

Case of paediatric steroid-induced glaucoma showing extremely fast progression with deformation of lamina cribrosa.

Clin Exp Optom 2019 Apr 17. Epub 2019 Apr 17.

Department of Medicine, Seoul National University College of Medicine, Seoul, Korea.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/cxo.12908DOI Listing

Color visual acuity in preperimetric glaucoma and open-angle glaucoma.

PLoS One 2019 17;14(4):e0215290. Epub 2019 Apr 17.

Department of Ophthalmology, Tohoku University Graduate School of Medicine, Sendai, Japan.

Purpose: To investigate the clinical significance of color visual acuity (CVA) in preperimetric glaucoma (PPG) and open-angle glaucoma (OAG).

Methods: A total of 123 eyes of 73 subjects (22 normal eyes, 14 PPG eyes, and 87 OAG eyes; mean age: 44.9 ± 10. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215290PLOS
April 2019
1 Read

Response to LTE: Considerations Regarding the Relationship between Anticoagulants Intake and Glaucoma Prognosis in Eyes With Optic Disc Hemorrhages.

Authors:
Kyung Rim Sung

J Glaucoma 2019 Apr 15. Epub 2019 Apr 15.

Department of Ophthalmology, University of Ulsan, College of Medicine, Asan Medical Center, Seoul, Korea.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/IJG.0000000000001266DOI Listing

Outcomes of a Modified Trabeculectomy Closure Technique.

J Glaucoma 2019 Apr 15. Epub 2019 Apr 15.

Wilmer Eye Institute, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Precis: A modified closure for trabeculectomy in which the conjunctiva is incised posterior to the limbus and re-approximated using 2 nylon sutures, provided similar surgical outcomes to the standard trabeculectomy closure technique.

Purpose: To examine the surgical outcomes of a modified trabeculectomy closure technique in which the conjunctiva is incised posterior to the limbus and re-approximated using two sutures, burying the posterior conjunctiva under an anterior lip of conjunctiva.

Methods: This retrospective review included 73 eyes that underwent trabeculectomies between 2015-2017 at Johns Hopkins Hospital by a single surgeon. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/IJG.0000000000001263DOI Listing
April 2019
1 Read

Glaucoma in Phacomatosis Pigmentovascularis in a Young African Male: A Case Report.

J Glaucoma 2019 Apr 15. Epub 2019 Apr 15.

Division of Ophthalmology, Faculty of Medicine and Health Sciences, Tygerberg Academic Hospital and Stellenbosch University, Cape Town, South Africa.

Background: Phacomatosis pigmentovascularis has previously almost exclusively been reported in Asians and in dermatological journals. In this report, we present a case of a young black South African male referred to our eye clinic.

Case Presentation: A 15-year-old male patient presented with gradual, painless loss of vision in his right eye. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/IJG.0000000000001264DOI Listing
April 2019
1 Read

Detection of proteins associated with extracellular matrix regulation in the aqueous humour of patients with primary glaucoma.

Curr Eye Res 2019 Apr 17. Epub 2019 Apr 17.

a R.S. Mehta Jain Department of Biochemistry and Cell Biology , KBIRVO, Vision Research Foundation, Sankara Nethralaya , Chennai , India .

Purpose: The protein composition of aqueous humour (AH) has held significant relevance and remains to be the prime sample in the discovery of biomarkers in glaucoma. The purpose of this study is to analyze the aqueous humour protein concentrations in primary open angle glaucoma (POAG) and primary angle closure glaucoma (PACG) and further examine the proteome changes compared to cataract control.

Methods: Aqueous humour was collected from 90 POAG, 72 PACG, 78 cataract (control) in this study. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/02713683.2019.1608261DOI Listing
April 2019
1.663 Impact Factor

Establishing an allied health professional delivered selective laser trabeculoplasty service in Scotland.

Ophthalmic Physiol Opt 2019 May;39(3):216-223

Tennent Institute of Ophthalmology, Gartnavel General Hospital, NHS Greater Glasgow and Clyde, Glasgow, Scotland.

Purpose: To describe the process of establishing a selective laser trabeculoplasty (SLT) service delivered by experienced allied health professionals (AHP) in a Scottish NHS Hospital Eye Service, and assess the safety and efficacy in comparison with SLT performed by ophthalmologists.

Methods: A training scheme for AHPs who were experienced in extended roles within the glaucoma service was developed, consisting of supervised training by a consultant ophthalmologist specialising in glaucoma leading to the AHPs independently delivering SLT. A prospective audit of consecutive SLT procedures performed by AHPs between November 2015 and April 2017 was performed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/opo.12611DOI Listing

Impact of optical coherence tomography on diagnostic decision-making by UK community optometrists: a clinical vignette study.

Ophthalmic Physiol Opt 2019 May;39(3):205-215

Division of Optometry and Visual Science, City University of London, London, UK.

Purpose: In recent years, there has been widespread investment in imaging technologies by community optometrists in the UK, most notably optical coherence tomography (OCT). The aim of the current study was to determine the value of OCT in the diagnosis of posterior segment diseases in a representative sample of community optometrists using a clinical vignette methodology.

Methods: A group of community optometrists (n = 50) initially completed a standardised training package on OCT interpretation followed by a computer-based assessment featuring 52 clinical vignettes, containing images of healthy (n = 8) or glaucomatous (n = 18) discs or healthy (n = 8) or diseased (n = 18) fundi. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/opo.12613DOI Listing

Changes in the anterior segment of the eye following uncomplicated pars plana vitrectomy. A review.

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 2019 Apr 17. Epub 2019 Apr 17.

Clinic of Ophthalmology, University Hospital Ostrava, Czech Republic.

Pars plana vitrectomy is currently the most common technique used in retinal surgery. Although primarily involving the posterior segment of the eye it also affects the anterior segment. As this is a less published topic, the aim of this paper was to review the literature on changes in the anterior segment after uncomplicated pars plana vitrectomy using data based literature search. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5507/bp.2019.014DOI Listing

PACAP Attenuates Optic Nerve Crush-Induced Retinal Ganglion Cell Apoptosis Via Activation of the CREB-Bcl-2 Pathway.

J Mol Neurosci 2019 Apr 16. Epub 2019 Apr 16.

State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, 7 Jinsui Road, Guangzhou, 510623, China.

Retinal ganglion cell (RGC) apoptosis is considered an important pathological hallmark of glaucoma. Pituitary adenylate cyclase-activating polypeptide (PACAP) is a pleiotropic peptide with potent neuroprotective properties. In our previous study, we found that the expression of PACAP and its high-affinity receptor PACAP receptor type 1 (PAC1R) increased markedly after optic nerve crush (ONC), and occurred mainly in the ganglion cell layer of the retina. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12031-019-01309-9DOI Listing

Effect of cytoglobin overexpression on extracellular matrix component synthesis in human tenon fibroblasts.

Biol Res 2019 Apr 16;52(1):23. Epub 2019 Apr 16.

Department of Ophthalmology, The First Affiliated Hospital, Harbin Medical University, 23 Youzheng Street, Harbin, 150001, Heilongjiang Province, People's Republic of China.

Background: Conjunctival filtering bleb scar formation is the main reason for the failure of glaucoma filtration surgery. Cytoglobin (Cygb) has been reported to play an important role in extracellular matrix (ECM) remodeling, fibrosis and tissue damage repairing. This study aimed to investigate the role of Cygb in anti-scarring during excessive conjunctival wound healing after glaucoma filtration surgery. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s40659-019-0229-4DOI Listing

Doubles trouble-85 cases of ocular trauma in badminton: clinical features and prevention.

Br J Sports Med 2019 Apr 15. Epub 2019 Apr 15.

Department of Ophthalmology, Beijing Tongren Hospital, Capital Medical University, Beijing, China.

Objectives: To describe ocular injuries caused by badminton and to explore the implications for future prevention strategies.

Methods: We enrolled 85 patients with ocular trauma caused by badminton. Information collected from patients included type of game, instigator, instrument of injury and lessons in badminton from a professional, and ocular trauma information such as type of injury, treatment and final outcomes. Read More

View Article

Download full-text PDF

Source
http://bjsm.bmj.com/lookup/doi/10.1136/bjsports-2018-099496
Publisher Site
http://dx.doi.org/10.1136/bjsports-2018-099496DOI Listing
April 2019
1 Read

The protective variant rs7173049 at LOXL1 locus impacts on retinoic acid signaling pathway in pseudoexfoliation syndrome.

Hum Mol Genet 2019 Apr 15. Epub 2019 Apr 15.

Department of Ophthalmology, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.

LOXL1 (lysyl oxidase-like 1) has been identified as the major effect locus in pseudoexfoliation (PEX) syndrome, a fibrotic disorder of the extracellular matrix and frequent cause of chronic open-angle glaucoma. However, all known PEX-associated common variants show allele effect reversal in populations of different ancestry, casting doubt on their biological significance. Based on extensive LOXL1 deep sequencing, we report here the identification of a common noncoding sequence variant, rs7173049A>G, located downstream of LOXL1, consistently associated with a decrease in PEX risk (OR=0. Read More

View Article

Download full-text PDF

Source
https://academic.oup.com/hmg/advance-article/doi/10.1093/hmg
Publisher Site
http://dx.doi.org/10.1093/hmg/ddz075DOI Listing
April 2019
5 Reads

Osteo-odonto-, Tibial bone and Boston keratoprosthesis in clinically comparable cases of chemical injury and autoimmune disease.

Ocul Surf 2019 Apr 12. Epub 2019 Apr 12.

Centro de Oftalmología Barraquer, Barcelona, Spain; Institut Universitari Barraquer, Universitat Autònoma de Barcelona, Barcelona, Spain; Universitat Internacional de Catalunya, Barcelona, Spain.

Purpose: To compare anatomical and functional results between three types of keratoprosthesis (KPro) in chemical injury and autoimmune disease.

Methods: 70 clinically comparable cases were included as follows: Boston KPro Type 1 25 eyes, osteo-odonto-keratoprosthesis (OOKP) 23 eyes, Tibial bone KPro 22 eyes. Survival times for anatomical and functional success were evaluated with Kaplan-Meier estimations and Log-rank tests. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jtos.2019.04.006DOI Listing

Investigating the Immediate and Cumulative Effects of Isometric Squat Exercise for Different Weight Loads on Intraocular Pressure: A Pilot Study.

Sports Health 2019 Apr 15:1941738119834985. Epub 2019 Apr 15.

Department of Physical Education and Sport, Faculty of Sport Sciences, University of Granada, Spain.

Background: The execution of resistance exercise against heavy loads promotes an acute intraocular pressure (IOP) rise, which has detrimental effects on ocular health. However, the effect of load on the IOP behavior during exercise remains unknown due to technical limitations.

Hypotheses: IOP monitoring during isometric squat exercise permits assessment of IOP behavior during physical effort. Read More

View Article

Download full-text PDF

Source
http://journals.sagepub.com/doi/10.1177/1941738119834985
Publisher Site
http://dx.doi.org/10.1177/1941738119834985DOI Listing
April 2019
1 Read

An overview of optical coherence tomography angiography and the posterior pole.

Ther Adv Ophthalmol 2019 Jan-Dec;11:2515841419840249. Epub 2019 Apr 3.

Department of Ophthalmology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.

Optical coherence tomography angiography is a relatively new, noninvasive technology that has revolutionized imaging of the retinal and choroidal microvasculature. This technology is based on the detection of movement or changes that represent moving red cells in sequential optical coherence tomography scans. As with other established imaging technologies, it has unique benefits as well as certain disadvantages, which include a limited field of view and vulnerability to imaging artifacts. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/2515841419840249DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448101PMC

Optic neuritis in an immunocompetent 40-year-old female due to fungal sphenoidal sinusitis.

GMS Ophthalmol Cases 2019 1;9:Doc06. Epub 2019 Mar 1.

Department of Glaucoma, Aravind Eye Hospital & Postgraduate Institute of Ophthalmology, Coimbatore, Tamilnadu, India.

Fungal shpenoidal sinusitis with osteomyelitis is rare in young immunocompetent patients. We present a case of a presumed fungal sphenoidal sinusitis presenting with second and sixth cranial nerve involvement which resolved well with systemic anti-fungal treatment. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3205/oc000095DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6436000PMC

Bilateral angle closure glaucoma in a teenage girl - A rare presentation in Arab population - A case report.

Authors:
Sultan Alzuhairy

Int J Health Sci (Qassim) 2019 Mar-Apr;13(2):56-58

Department of Ophthalmology, College of Medicine, Qassim University, Qassim, Saudi Arabia.

Primary angle closure glaucoma (PACG) usually presents as unilateral and has acute onset. In Arab population, the proportion of open- and closed-angle glaucoma is similar. To the best of our knowledge, chronic PACG in very young age is rare. Read More

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6436444PMC

[Congenital aniridia in children].

Rev Prat 2019 Jan;69(1):67-70

Service d'ophtalmologie, hôpital Necker Enfants-malades, AP-HP, centre de maladies rares OPHTARA, université Paris-Descartes, université Sorbonne-Paris-Cité, Paris, France. Unité CNRS FR3636, université Paris-Descartes, université Sorbonne-Paris-Cité, Paris, France. Coordonnateur du Centre OPHTARA maladies rares en Ophtalmologie, Centre Européen ERN EYE. Présidente du CMS Geniris et Aniridia Europe.

Congenital aniridia in children. Congenital aniridia is a genetic rare disease that affects the entire eyeball (pan-ocular disease). The disease is characterized by partial or complete absence of iris. Read More

View Article

Download full-text PDF

Source
January 2019
1 Read

Higher Reliance on Glycolysis Limits Glycolytic Responsiveness in Degenerating Glaucomatous Optic Nerve.

Mol Neurobiol 2019 Apr 13. Epub 2019 Apr 13.

Department of Pharmaceutical Sciences, Northeast Ohio Medical University, 4209 State Route 44, Rootstown, OH, 44272, USA.

Metabolic dysfunction accompanies neurodegenerative disease and aging. An important step for therapeutic development is a more sophisticated understanding of the source of metabolic dysfunction, as well as to distinguish disease-associated changes from aging effects. We examined mitochondrial function in ex vivo aging and glaucomatous optic nerve using a novel approach, the Seahorse Analyzer. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12035-019-1576-4DOI Listing

Early diagnostic parameters of glaucoma in high myopes.

J Fr Ophtalmol 2019 Apr 9. Epub 2019 Apr 9.

Cairo university, Cairo, Egypt.

Purpose: The goal of this study was to assess changes in OCT parameters occurring in high myopic glaucoma patients, so as to enable early diagnosis and prevention of progressive glaucomatous damage. It was performed at the department of ophthalmology, Kasr Alainy Hospital, Cairo University, over a twenty-month period.

Methods: This study was a cross-sectional randomized single blinded study. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jfo.2018.11.011DOI Listing

Referral to community care from school-based eye care programs in the United States.

Surv Ophthalmol 2019 Apr 9. Epub 2019 Apr 9.

Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD; Dana Center for Preventive Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, MD; Berman Institute of Bioethics, Johns Hopkins University, Baltimore, MD. Electronic address:

Approximately 25% of school-aged children in the United States have vision abnormalities, most commonly refractive error that can be corrected with spectacles. Limited follow-up adherence after failed school-based vision screening led to an increase in school-based eye care programs that provide screening, eye examinations, and spectacle prescription at the school. These programs address the access barrier and often provide the first point of contact between children and eye care. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S00396257183022
Publisher Site
http://dx.doi.org/10.1016/j.survophthal.2019.04.003DOI Listing
April 2019
3 Reads

Mapping mRNA expression of glaucoma genes in the healthy mouse eye.

Curr Eye Res 2019 Apr 12. Epub 2019 Apr 12.

a University Eye Clinic Maastricht, Maastricht University Medical Center , Maastricht , the Netherlands.

Purpose/Aim: Many genes have been associated with primary open-angle glaucoma (POAG). Knowing exactly where they are expressed in the eye helps to unravel POAG pathology and to select optimal targets for intervention. We investigated whether RNA in-situ hybridization (RNA-ISH) is a convenient technique to obtain detailed pan-ocular expression data of these genes. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/02713683.2019.1607392DOI Listing

Mobile Telephone Use and Reaction Time in Drivers With Glaucoma.

JAMA Netw Open 2019 Apr 5;2(4):e192169. Epub 2019 Apr 5.

Visual Performance Laboratory, Duke Eye Center, Department of Ophthalmology, Duke University, Durham, North Carolina.

Importance: Combining mobile telephone use with driving is not unusual. However, distracted driving limits driving performance because of limited capacity for persons to divide attention.

Objectives: To investigate the frequency of mobile telephone use while driving and to assess whether patients with glaucoma had a disproportionate decrease in driving performance while conversing on a mobile telephone compared with healthy participants. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1001/jamanetworkopen.2019.2169DOI Listing

Clinical application of NGS-based SNP haplotyping for the preimplantation genetic diagnosis of primary open angle glaucoma.

Syst Biol Reprod Med 2019 Apr 12:1-6. Epub 2019 Apr 12.

b Prenatal Diagnosis Centre , Northwest Women's and Children's Hospital , Xi'an , China.

The current study describes a successful case of preimplantation genetic diagnosis (PGD) of primary open angle glaucoma (POAG) and verifies the efficiency of next-generation sequencing (NGS)-based haplotyping for PGD of POAG. In this study, we applied NGS as part of PGD to effectively detect POAG prior to embryo implantation and avoid the prospect of pregnancy termination in event of vertical inheritance of POAG. We used the technique of multiple annealing and looping based amplification cycles (MALBAC) to conduct whole genome amplification (WGA) and to reduce the allele dropout (ADO). Read More

View Article

Download full-text PDF

Source
https://www.tandfonline.com/doi/full/10.1080/19396368.2019.1
Publisher Site
http://dx.doi.org/10.1080/19396368.2019.1590479DOI Listing
April 2019
2 Reads

Comparison of Blue and Green Confocal Scanning Laser Ophthalmoscope Imaging to Detect Retinal Nerve Fiber Layer Defects.

Korean J Ophthalmol 2019 Apr;33(2):131-137

Department of Ophthalmology, Hanyang University College of Medicine, Seoul, Korea.

Purpose: We detected retinal nerve fiber layer (RNFL) defects using a confocal scanning laser ophthalmoscopy (CSLO) with both blue and green laser sources and evaluated image quality based on laser wavelength.

Methods: This was a retrospective observational case study. Blue and green CSLO images of 181 eyes with suspected glaucoma were evaluated and compared. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3341/kjo.2018.0075DOI Listing

Clinical Efficacy of Custom-built Software for the Early Detection of Glaucoma: A Comparison of Axial-length and Major Retinal Artery Location Data.

Korean J Ophthalmol 2019 Apr;33(2):103-112

Department of Ophthalmology, CHA Bundang Medical Center, CHA University, Seongnam, Korea.

Purpose: To assess the clinical efficacy for early detection of glaucoma using custom-built image software visualizing translucent retinal nerve fiber layer thickness (RNFLT) that is graphed based on a normative database.

Methods: This prospective study was conducted using a normative database constructed with RNFLT data of 151 healthy Korean eyes. The reference lines of the mean, the lower 5%, and the lower 1% limit were visualized as a translucent RNFLT graph produced by our software after inputting each subject's major retinal artery position and overlaying the results onto the RNFLT measurements. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3341/kjo.2018.0060DOI Listing

Mechanisms of neurodegeneration in a preclinical autosomal dominant retinitis pigmentosa knock-in model with a Rho mutation.

Cell Mol Life Sci 2019 Apr 11. Epub 2019 Apr 11.

Jonas Children's Vision Care and Bernard & Shirlee Brown Glaucoma Laboratory, Departments of Ophthalmology, Pathology, and Cell Biology, Columbia University, New York, NY, 10032, USA.

D190N, a missense mutation in rhodopsin, causes photoreceptor degeneration in patients with autosomal dominant retinitis pigmentosa (adRP). Two competing hypotheses have been developed to explain why D190N rod photoreceptors degenerate: (a) defective rhodopsin trafficking prevents proteins from correctly exiting the endoplasmic reticulum, leading to their accumulation, with deleterious effects or (b) elevated mutant rhodopsin expression and unabated signaling causes excitotoxicity. A knock-in D190N mouse model was engineered to delineate the mechanism of pathogenesis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00018-019-03090-9DOI Listing

Spontaneous resolution of myopic retinoschisis.

AME Case Rep 2019 13;3. Epub 2019 Feb 13.

Ophthalmology Department, Hong Kong Adventist Hospital, Hong Kong, China.

Spontaneous resolution of myopic retinoschisis is an unusual event due to the fact that most eyes of patients with this condition have already undergone certain morphological changes and vision will progressively worsen over time. We present a case of spontaneous anatomic and visual improvement in a myopic eye with a macular retinoschisis. The patient was monocular oculus dextrus (OD) with a history of left eye enucleation for recurrent retinal detachment and glaucoma for 30 years prior. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.21037/acr.2019.01.04DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6414358PMC
February 2019

Evaluation of intraocular pressure and retinal nerve fiber layer, retinal ganglion cell, central macular thickness, and choroidal thickness using optical coherence tomography in obese children and healthy controls.

Niger J Clin Pract 2019 Apr;22(4):539-545

Department of Pediatric Endocrinology, Faculty of Medicine, Hacettepe University, Ankara, Turkey.

Objective: Obesity affects many organ systems. There have been few studies on the ophthalmological effects of obesity. The aim of the present study was to evaluate the changes in the ophthalmological parameters in obese children. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4103/njcp.njcp_471_18DOI Listing

Randomized crossover trial comparing effectiveness and tolerability of generic and brand-name travoprost.

Can J Ophthalmol 2019 Apr 22;54(2):223-228. Epub 2018 Jun 22.

Department of Ophthalmology, Centre Hospitalier Universitaire de Sherbrooke - Hôtel-Dieu, University of Sherbrooke, Sherbrooke, Quebec.

Objective: The primary goal is to determine if the intraocular pressure reducing effect of generic Sandoz travoprost is equivalent to that of brand-name Travatan Z. The secondary goal is to determine if generic Sandoz travoprost is as well tolerated as Travatan Z.

Methods: This prospective randomized crossover trial allocated 76 patients with primary open-angle glaucoma, normotensive glaucoma, or ocular hypertension in a 1:1 ratio to start with either generic Sandoz travoprost or Travatan Z. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jcjo.2018.04.017DOI Listing

Secondary surgical intervention after primary glaucoma filtration surgery: an Ontario population-based study.

Can J Ophthalmol 2019 Apr 20;54(2):212-222. Epub 2018 Jun 20.

Schulich School of Medicine and Dentistry Department of Ophthalmology, Ontario, Canada; Schulich School of Medicine and Dentistry Department of Pathology and Laboratory Medicine, Ontario, Canada.

Objective: To identify factors associated with secondary surgical intervention after glaucoma filtration surgery.

Design: Population-based retrospective cohort.

Methods: Patient records with billing claims for a primary glaucoma filtration surgery occurring between April 2003 and March 2015 were identified. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jcjo.2018.04.004DOI Listing

Descemet membrane endothelial keratoplasty in iridocorneal endothelial syndrome and posterior polymorphous corneal dystrophy.

Can J Ophthalmol 2019 Apr 23;54(2):190-195. Epub 2018 Aug 23.

Department of Ophthalmology and Vision Sciences, Toronto Western Hospital, University of Toronto, Toronto, Ont.

Objective: To report the clinical outcome of Descemet membrane endothelial keratoplasty (DMEK) in cases of corneal decompensation secondary to iridocorneal endothelial syndrome (ICE) or posterior polymorphous corneal dystrophy (PPCD).

Design: Retrospective interventional case series.

Participants: Eight eyes of 7 patients that underwent DMEK due to corneal decompensation secondary to either ICE syndrome or PPCD, and had at least 6 months of postoperative follow-up. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jcjo.2018.05.012DOI Listing

Evaluation of dynamic thiol-disulfide homeostasis in glaucoma patients and the correlation with retinal nerve fiber layer analysis.

Eur J Ophthalmol 2019 Apr 12:1120672119839582. Epub 2019 Apr 12.

3 Biochemistry Department, Ankara Atatürk Education and Research Hospital, Ankara, Turkey.

Purpose: The aim of this study was to evaluate thiol/disulfide homeostasis and ischemia-modified albumin levels with primary open-angle glaucoma, ocular hypertension, and control group; also to interpret the correlation between these biochemical parameters and retinal nerve fiber layer analysis.

Material And Methods: In a prospective cross-sectional study, 30 primary open-angle glaucoma cases, 30 ocular hypertension cases, and 30 control subjects were included in the study. Native thiol, total thiol, and disulfide measurements and disulfide/native thiol, disulfide/total thiol, and native thiol/total thiol ratios were evaluated as thiol-disulfide homeostasis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1120672119839582DOI Listing

Empowering Mesenchymal Stem Cells for Ocular Degenerative Disorders.

Int J Mol Sci 2019 Apr 10;20(7). Epub 2019 Apr 10.

Department of Biomedical Science, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia.

Multipotent mesenchymal stem cells (MSCs) have been employed in numerous pre-clinical and clinical settings for various diseases. MSCs have been used in treating degenerative disorders pertaining to the eye, for example, age-related macular degeneration, glaucoma, retinitis pigmentosa, diabetic retinopathy, and optic neuritis. Despite the known therapeutic role and mechanisms of MSCs, low cell precision towards the targeted area and cell survivability at tissue needing repair often resulted in a disparity in therapeutic outcomes. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/ijms20071784DOI Listing
April 2019
1 Read

Comparison of two prototypes of a magnetically adjustable glaucoma implant in rabbits.

PLoS One 2019 11;14(4):e0215316. Epub 2019 Apr 11.

Small Animal Clinic, University of Veterinary Medicine Hannover, Foundation, Hannover, Germany.

Glaucoma drainage devices are used in surgical glaucoma therapy. Success of controlling the intraocular pressure is limited due to fibrous implant encapsulation and fibrin coating on the implant which lead to drainage obstructions. An innovative implant with a magnetically adjustable valve was developed. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215316PLOS
April 2019
1 Read

Nailfold Capillaroscopy of Resting Peripheral Blood Flow in Exfoliation Glaucoma and Primary Open-Angle Glaucoma.

JAMA Ophthalmol 2019 Apr 11. Epub 2019 Apr 11.

Einhorn Clinical Research Center, Department of Ophthalmology, New York Eye and Ear Infirmary of Mount Sinai, New York.

Importance: Systemic blood flow alterations have been described using video nailfold capillaroscopy (NFC) in high-tension glaucoma (HTG) and normal-tension glaucoma (NTG) variants of primary open-angle glaucoma (POAG). To date, no previous studies have explored alterations in nailfold capillary blood flow in exfoliation glaucoma (XFG).

Objective: To investigate the measure of peripheral blood flow as a surrogate marker of systemic vascular involvement in patients with XFG, HTG, and NTG, as well as in individuals serving as controls, using NFC. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1001/jamaophthalmol.2019.0434DOI Listing

Acute Phacolytic Glaucoma and Morgagnian Cataract.

JAMA Ophthalmol 2019 Apr 11;137(4):e184495. Epub 2019 Apr 11.

Department of Ophthalmology and Visual Sciences, Dalhousie University, Halifax, Nova Scotia, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1001/jamaophthalmol.2018.4495DOI Listing
April 2019
1 Read

Glaucoma in the Age of E-learning.

J Glaucoma 2019 Apr 8. Epub 2019 Apr 8.

Glaucoma Center of San Francisco, San Francisco, CA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/IJG.0000000000001261DOI Listing

Overuse and Underuse of Visual Field Testing Over 15 Years.

J Glaucoma 2019 Apr 9. Epub 2019 Apr 9.

Goldschleger Eye Institute, Sheba Medical Center, Tel Hashomer, Israel, affiliated to the Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.

PRéCIS:: A 15-year analysis of 198,843 visual field tests revealed a growing trend for their performance for non-glaucoma indications. Adherence to glaucoma management guidelines was suboptimal. Guidelines for referral to visual field assessments should be established. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/IJG.0000000000001262DOI Listing