67,183 results match your criteria Glaucoma Today [Journal]


Clinical Manifestations, Prognosis And Vaccination Status Of Patients With Rubella Virus-Associated Uveitis.

Am J Ophthalmol 2019 Feb 13. Epub 2019 Feb 13.

Department of Ophthalmology, Erasmus University Medical Center, Rotterdam, The Netherlands.

Purpose: To assess the clinical and laboratory manifestations and vaccination status of uveitis patients positive for Rubella virus (RV) in aqueous humor and investigate its relationship to Fuchs Uveitis Syndrome (FUS).

Methods: Retrospective study of all uveitis patients, positive for RV in aqueous humor analysis (polymerase chain reaction (PCR) and/or Goldmann-Witmer coefficient (GWC)) between January 2010 and October 2016 at the ophthalmology departments in the Erasmus Medical Center (Rotterdam) and University Medical Center Utrecht. Outcomes of aqueous analyses of FUS patients during this period were assessed. Read More

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http://dx.doi.org/10.1016/j.ajo.2019.02.002DOI Listing
February 2019

Fluctuations of the intraocular pressure in medically versus surgically treated glaucoma patients by a contact lens sensor.

Am J Ophthalmol 2019 Feb 13. Epub 2019 Feb 13.

Translational Research in Respiratory Medicine; Arnau de Vilanova-Santa María University Hospital; IRBLleida, Catalonia, Spain.

Purpose: To compare fluctuations in intraocular pressure (IOP) in medically versus surgically treated glaucoma patients.

Design: Prospective, non-randomized case series.

Methods: IOP-related fluctuations were measured for 24 hours using a contact lens sensor (CLS). Read More

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http://dx.doi.org/10.1016/j.ajo.2019.02.003DOI Listing
February 2019

Longitudinal Study of Peripapillary Thinning in Sickle Cell Hemoglobinopathies.

Am J Ophthalmol 2019 Feb 13. Epub 2019 Feb 13.

Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, IL. Electronic address:

Purpose: To determine the rate of retinal nerve fiber layer (RNFL) thinning in patients with sickle cell hemoglobinopathies. Design; Prospective cohort study METHODS: Sixty-seven patients averaging 35.8±11. Read More

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http://dx.doi.org/10.1016/j.ajo.2019.02.006DOI Listing
February 2019

Transplantation of cultured olfactory mucosal cells rescues optic nerve axons in a rat glaucoma model.

Brain Res 2019 Feb 13. Epub 2019 Feb 13.

Spinal Repair Unit, Department of Brain Repair and Rehabilitation, UCL Institute of Neurology, Queen Square, London WC1N 3BG, UK. Electronic address:

Purpose: To determine whether transplantation of olfactory mucosal cells (OMCs) is able to rescue the loss of optic nerve axons after the intraocular pressure (IOP) is elevated in rats.

Methods: The IOP was raised by injection of magnetic microspheres into the anterior chamber of the eye. OMCs cultured from the adult olfactory mucosa were transplanted into the region of the optic disc. Read More

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http://dx.doi.org/10.1016/j.brainres.2019.02.010DOI Listing
February 2019

Intracameral Phenylephrine to Arrest Intraoperative Intraocular Bleeding: A New Technique.

Ophthalmol Ther 2019 Feb 15. Epub 2019 Feb 15.

The Western Eye Hospital, Imperial College NHS Trust, London, UK.

Intraoperative intraocular bleeding can present a major challenge during anterior segment operations, such as cataract and glaucoma surgery. In the presence of significant intraocular bleeding, the surgeon may be unable to proceed if the bleeding cannot be controlled. Uncontrolled bleeding may also result in intraoperative or postoperative complications. Read More

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http://dx.doi.org/10.1007/s40123-019-0165-yDOI Listing
February 2019

Structure-function relationships in glaucoma using enhanced depth imaging optical coherence tomography-derived parameters: a cross-sectional observational study.

BMC Ophthalmol 2019 Feb 15;19(1):52. Epub 2019 Feb 15.

Glaucoma Service, Department of Ophthalmology, Federal University of São Paulo, Rua Botucatu, 821, Vila Clementino, São Paulo, 04021-001, Brazil.

Background: To investigate structural and functional correlations in glaucoma patients using enhanced depth imaging spectral-domain optical coherence tomography (EDI OCT)-derived parameters.

Methods: We prospectively enrolled healthy participants and glaucomatous patients with a wide range of disease stages. All participants underwent visual field (VF) testing (SITA - Standard 24-2; Carl Zeiss Meditec, Dublin, CA) and EDI OCT imaging (Spectralis; Heidelberg Engineering Co. Read More

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http://dx.doi.org/10.1186/s12886-019-1054-9DOI Listing
February 2019

Philadelphia Telemedicine Glaucoma Detection and Follow-up Study: confirmation between eye screening and comprehensive eye examination diagnoses.

Br J Ophthalmol 2019 Feb 15. Epub 2019 Feb 15.

Glaucoma Service, Wills Eye Hospital, Philadelphia, Pennsylvania, USA.

Aims: To evaluate agreement between ocular findings of a telemedicine eye screening (visit 1) with diagnoses of a comprehensive eye examination (visit 2).

Methods: A primary care practice (PCP)-based telemedicine screening programme incorporating fundus photography, intraocular pressure (IOP) and clinical information was conducted. Eligible individuals were African American, Hispanic/Latino or Asian over the age of 40; Caucasian individuals over age 65; and adults of any ethnicity over age 40 with a family history of glaucoma or diabetes. Read More

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http://dx.doi.org/10.1136/bjophthalmol-2018-313451DOI Listing
February 2019

Baseline Ocular Characteristics of Patients Undergoing Initiation of Anti-Vascular Endothelial Growth Factor Therapy for Diabetic Macular Edema.

Ophthalmic Surg Lasers Imaging Retina 2019 Feb;50(2):69-75

Background And Objectives: Patients with diabetic macular edema (DME) have variable anatomic and visual responses to anti-vascular endothelial growth (VEGF) treatments based on their presenting visual acuity (VA). The aim of study is to report the baseline ocular and imaging characteristics of patients presenting with DME who were treatment-naïve and who initiated anti-VEGF in routine clinical practice.

Patients And Methods: Single-center, cross-sectional study of 638 patients. Read More

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http://dx.doi.org/10.3928/23258160-20190129-02DOI Listing
February 2019

Transfixion technique for the treatment of silicone oil pupillary block glaucoma refractory to Nd-YAG iridotomy.

Cir Cir 2019 ;87(2):215-218

Facultad de Medicina, Universidad Michoacana de San Nicolás de Hidalgo, Morelia, Michoacán, México.

Background: Pupillary block induced by silicon oil in vitrectomized patients is a common condition usually treated with Nd-YAG laser iridotomy or with surgical removal of silicon oil.

Case Report: A case of silicone oil pupillary block glaucoma successfully treated with a 30 G needle transfixion technique is described. We performed a non-complicated vitrectomy surgery for retinal detachment with proliferative vitreoretinopathy that included lensectomy, inferior peripheral iridectomy, and silicone oil injection. Read More

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http://www.cirugiaycirujanos.com/frame_esp.php?id=130
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http://dx.doi.org/10.24875/CIRU.18000386DOI Listing
January 2019
4 Reads

Novel ocular findings in oculodentodigital dysplasia (ODDD): a case report and literature review.

Ophthalmic Genet 2019 Feb 15:1-6. Epub 2019 Feb 15.

a State Key Laboratory of Ophthalmology , Zhongshan Ophthalmic Center, Sun Yat-Sen University , Guangzhou , Guangdong , China.

Background: Oculodentodigitaldysplasia (ODDD; MIM no. 164200) is a rare hereditary disorder caused by mutations in the gene GJA1.Ocular disorders included microcornea, cornea opacity and glaucoma. Read More

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http://dx.doi.org/10.1080/13816810.2019.1571616DOI Listing
February 2019

Current management of glaucoma.

Med J Aust 2019 Feb 14. Epub 2019 Feb 14.

University of Sydney, Sydney, NSW.

Glaucoma is an irreversible progressive optic neuropathy, for which the major proven treatment is to lower the intraocular pressure (IOP). Five groups of IOP-lowering eye drops have varying mechanisms of action. Some drops, such as β-blockers and α-2 agonists, have potentially serious systemic side effects. Read More

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http://dx.doi.org/10.5694/mja2.50020DOI Listing
February 2019

Glaucoma in perspective.

Med J Aust 2019 Feb 14. Epub 2019 Feb 14.

Royal Victorian Eye and Ear Hospital, Melbourne, VIC.

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http://dx.doi.org/10.5694/mja2.50011DOI Listing
February 2019

Effective treatment of refractory sympathetic ophthalmia with glaucoma using adalimumab.

Am J Ophthalmol Case Rep 2019 Jun 25;14:1-4. Epub 2019 Jan 25.

Department of Ophthalmology and Visual Science, Graduate School of Biomedical Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima City, Hiroshima, 734-8551, Japan.

Purpose: Sympathetic ophthalmia (SO) is an autoimmune, bilateral, granulomatous panuveitis, which occurs following penetrating eye injury or eye surgery. We report two cases of refractory SO in patients with a history of trabeculectomy, which were treated effectively with adalimumab.

Observations: Case 1: A 69-year-old male with a history of trabeculectomy for rubeotic glaucoma of the right eye, secondary to diabetic retinopathy 8 years prior, presented with a decrease in visual acuity of the left eye due to SO. Read More

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http://dx.doi.org/10.1016/j.ajoc.2019.01.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360245PMC
June 2019
1 Read

Early Macular Angiography among Patients with Glaucoma, Ocular Hypertension, and Normal Subjects.

J Ophthalmol 2019 15;2019:7419470. Epub 2019 Jan 15.

Department of Ophthalmology, Show Chwan Memorial Hospital, Changhua, Taiwan.

Purpose: To evaluate early macular circulation in open-angle glaucoma (OAG), normal-tension glaucoma (NTG), ocular hypertension (OHT), and healthy subjects via optical coherence tomography angiography (OCTA).

Methods: A retrospective cross-sectional study was conducted. Medical records were reviewed, and the patients who received OCTA examinations were divided into the OAG, NTG, OHT, and normal groups. Read More

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http://dx.doi.org/10.1155/2019/7419470DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350555PMC
January 2019

The Association of Oxidative Stress Status with Open-Angle Glaucoma and Exfoliation Glaucoma: A Systematic Review and Meta-Analysis.

J Ophthalmol 2019 15;2019:1803619. Epub 2019 Jan 15.

Department of Clinical Laboratory, Eye & ENT Hospital, Shanghai Medical College, Fudan University, Shanghai, China.

Purpose: To systematically evaluate the associations between oxidative stress status and different types of glaucoma.

Design: Systematic review and meta-analysis.

Methods: We searched PubMed, EMBASE, and the Web of Science for randomized controlled trials written in the English language between January 1, 1990, and November 30, 2016. Read More

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http://dx.doi.org/10.1155/2019/1803619DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350588PMC
January 2019

Resilience Mediates the Relationship Between Social Support and Quality of Life in Patients With Primary Glaucoma.

Front Psychiatry 2019 31;10:22. Epub 2019 Jan 31.

Department of Ophthalmology, Xiangya Hospital, Central South University, Changsha, China.

Glaucoma is a serious disease causing blindness, which seriously affects the quality of life of patients. Previous studies have reported that both resilience and social support play important roles in enhancing the quality of life of patients with some diseases. The purpose of this study is to investigate if resilience mediates the relationship between social support and quality of life in patients with primary glaucoma. Read More

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http://dx.doi.org/10.3389/fpsyt.2019.00022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365462PMC
January 2019

Retinal Detachment After Cyclophotocoagulation in a Child with Knobloch Syndrome.

Middle East Afr J Ophthalmol 2018 Jul-Dec;25(3-4):161-162

Glaucoma Division, Wilmer Eye Institute, Johns Hopkins University, Baltimore, Maryland, USA.

Knobloch syndrome (KS) is typically characterized by high myopia, vitreoretinal degeneration, retinal detachment, and macular abnormalities. We report a case of glaucoma in KS, which represents the fourth reported case and the first description of the retinal events after the glaucoma procedure. Retinal detachment followed standard cyclophotocoagulation procedure for glaucoma in a 2-month-old boy. Read More

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http://dx.doi.org/10.4103/meajo.MEAJO_263_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348939PMC
February 2019

Comparative Clinical Study of Medically Controlled Nonsevere Chronic Primary Angle-closure Glaucoma with Coexisting Cataract Surgically Managed by Phacoemulsification as against Combined Phacotrabeculectomy.

Middle East Afr J Ophthalmol 2018 Jul-Dec;25(3-4):119-125

Research Department, King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia.

Purpose: Comparative clinical study of medically controlled non-severe chronic Primary Angle Closure Glaucoma (PACG) with co-existing cataract surgically managed by phacoemulsification as against combined phacotrabeculectomy.

Methods: This randomized clinical trial was conducted between December 2011 and December 2013. Patients were randomly assigned to Phacoemulsification (PE) and Phacotrabeculectomy (PT) groups for surgery. Read More

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http://dx.doi.org/10.4103/meajo.MEAJO_204_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348945PMC
February 2019

[Emotional and Psychological Peculiarities in Glaucoma].

Klin Monbl Augenheilkd 2019 Feb 14;236(2):154-157. Epub 2019 Feb 14.

Augenärztin, Praxis an der Lichtwiese, Darmstadt.

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http://dx.doi.org/10.1055/a-0834-6093DOI Listing
February 2019

[Glaucoma-Related Sleep Disorder and Associated Diseases].

Klin Monbl Augenheilkd 2019 Feb 14;236(2):150-153. Epub 2019 Feb 14.

Klinik und Poliklinik für Augenheilkunde, Universitätsklinikum Hamburg-Eppendorf.

The simultaneous occurrence of sleeping disorders and glaucoma is caused by multiple factors and, until today, the underlying mechanisms are not completely understood. There seems to be correlations, either between sleeping disorders in patients with a diagnosed glaucoma and between the onset of a glaucoma in patients with certain sleeping habits, but no precise data has been collected so far. Read More

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http://dx.doi.org/10.1055/a-0809-5735DOI Listing
February 2019

[Neuronal Blood Pressure Regulation].

Klin Monbl Augenheilkd 2019 Feb 14;236(2):145-149. Epub 2019 Feb 14.

Institut für Kreislaufforschung und Sportmedizin, Deutsche Sporthochschule Köln.

Neuronal blood pressure control is mediated by the autonomic nervous system. In this article, physiological and pathophysiological mechanisms will be recapitulated. Blood pressure regulation aims at maintaining adequate cardiac output and a sufficient perfusion pressure for the organs. Read More

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http://dx.doi.org/10.1055/a-0808-4843DOI Listing
February 2019

[The Importance of the Lymphatic and the Glymphatic System for Glaucoma].

Klin Monbl Augenheilkd 2019 Feb 14;236(2):142-144. Epub 2019 Feb 14.

Augenklinik, Kantonsspital Aarau, Schweiz.

Normal tension glaucoma is a variant of primary open angle glaucoma. It is characterized by normal intraocular pressure. Although there are several pathophysiological explanations (e. Read More

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http://dx.doi.org/10.1055/a-0809-5692DOI Listing
February 2019

[Impairment of the Visual System in Glaucoma].

Klin Monbl Augenheilkd 2019 Feb 14;236(2):134-141. Epub 2019 Feb 14.

Interdisziplinäres Zentrum für Präventive Augenheilkunde und Imaging, Augenklinik, Universitätsklinikum Erlangen.

MR Diffusion Tensor Imaging (DTI) enables visualisation of the visual system in glaucoma; it has been shown that the atrophy of the optic radiation is more pronounced in glaucoma than in age-matched controls. The atrophy of the optic radiation thereby correlates with OCT and visual field measures. Diffusion tensor imaging permits quantification of the axonal integrity of the optic radiation by calculation of fractional anisotropy (FA) and radial diffusivity (RD). Read More

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http://dx.doi.org/10.1055/a-0762-0822DOI Listing
February 2019

[Neurological Aspects of Glaucoma].

Authors:
Carl Erb

Klin Monbl Augenheilkd 2019 Feb 14;236(2):132-133. Epub 2019 Feb 14.

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http://dx.doi.org/10.1055/a-0818-1764DOI Listing
February 2019

[Prophylaxis of Recurrent Cytomegalovirus Uveitis with Topical Ganciclovir].

Klin Monbl Augenheilkd 2019 Feb 14. Epub 2019 Feb 14.

Augenklinik, UniversitätsSpital Zürich, Universität Zürich, Schweiz.

Purpose: Cytomegalovirus (CMV) can cause recurrent or chronic hypertensive anterior uveitis in immunocompetent patients. Antiviral treatment options include topical ganciclovir or systemic valganciclovir. However, recurrences are common after stopping treatment. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/a-0816-5598
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http://dx.doi.org/10.1055/a-0816-5598DOI Listing
February 2019
2 Reads

Visual Performance, Subjective Satisfaction and Quality of Life Effect of a New Refractive Intraocular Lens with Central Extended Depth of Focus.

Klin Monbl Augenheilkd 2019 Feb 14. Epub 2019 Feb 14.

Glaucoma Research Centre, Montchoisi Clinic, Swiss Visio Network, Lausanne, Switzerland.

Purpose: To assess the visual performance, clinical and quality of life outcomes, and subjective patient satisfaction after implantation of a new refractive/extended depth of focus (EDOF) hybrid intraocular lens (IOL).

Methods: This is a monocentric, retrospective study of 29 patients (45 eyes), carried out in a tertiary care glaucoma research centre. All patients underwent implantation of a Lucidis (Swiss Advanced Vision, SAV-IOL SA, Neuchâtel, Switzerland) IOL during cataract surgery. Read More

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http://dx.doi.org/10.1055/a-0799-9700DOI Listing
February 2019

The genetic influence on corticosteroid-induced ocular hypertension: A field positioned for discovery.

Am J Ophthalmol 2019 Feb 11. Epub 2019 Feb 11.

Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, 243 Charles Street, Boston, MA 02114. Electronic address:

Purpose: To provide evidence that corticosteroid-induced ocular hypertension has a genetic component.

Design: Evidence-based Perspective.

Methods: We conducted a comprehensive literature search for studies exploring genetic influences on intraocular pressure responses to corticosteroid treatment. Read More

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http://dx.doi.org/10.1016/j.ajo.2019.02.001DOI Listing
February 2019

ACUTE MACULAR AND PERIPAPILLARY ANGIOGRAPHIC CHANGES WITH INTRAVITREAL INJECTIONS.

Retina 2019 Feb 11. Epub 2019 Feb 11.

Department of Ophthalmology, The New York Eye and Ear Infirmary of Mount Sinai, New York, New York.

Purpose: Intravitreal injections acutely and temporarily increase intraocular pressure (IOP), and this may have cumulative long-term effects including an increased risk for glaucoma surgery. This study was designed to measure retinal perfusion density changes on optical coherence tomography (OCT) angiography and OCT thickness alterations associated with acutely increased IOP after intravitreal injections.

Methods: Retrospective observational clinical study of 40 eyes (39 patients) with various retinopathies from October 2016 to June 2017 at a tertiary care retina clinic in NYC. Read More

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http://dx.doi.org/10.1097/IAE.0000000000002433DOI Listing
February 2019
1 Read

Reply: Evaluation of Ocular Surface Disease in Patients with Glaucoma: Clinical Parameters, Self-report Assessment and Keratograph Analysis.

J Glaucoma 2019 Feb 12. Epub 2019 Feb 12.

Department of Ophthalmology and Visual Science, Glaucoma Service, Federal University of São Paulo, São Paulo, Brazil.

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http://dx.doi.org/10.1097/IJG.0000000000001214DOI Listing
February 2019

Evaluation of Ocular Surface Disease in Patients With Glaucoma: Clinical Parameters, Self Report Assessment, and Keratograph Analysis.

J Glaucoma 2019 Feb 12. Epub 2019 Feb 12.

Glaucoma Services, Dr. Shroff's Charity Eye Hospital, Daryaganj, Delhi - 110 002, India.

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http://dx.doi.org/10.1097/IJG.0000000000001213DOI Listing
February 2019

Kahook Dual Blade (KDB) in Severe and Refractory Glaucoma.

J Glaucoma 2019 Feb 12. Epub 2019 Feb 12.

Sita lakshmi glaucoma center, Anand eye institute, 7-147/1, Nagendra Nagar, Habsiguda, Hyderabad, Telangana, India.

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http://dx.doi.org/10.1097/IJG.0000000000001210DOI Listing
February 2019
1 Read

Fully Convolutional Networks for Monocular Retinal Depth Estimation and Optic Disc-Cup Segmentation.

IEEE J Biomed Health Inform 2019 Feb 14. Epub 2019 Feb 14.

Glaucoma is a serious ocular disorder for which the screening and diagnosis are carried out by the examination of the optic nerve head (ONH). The color fundus image (CFI) is the most common modality used for ocular screening. In CFI, the central region which is the optic disc and the optic cup region within the disc are examined to determine one of the important cues for glaucoma diagnosis called the optic cup-to-disc ratio (CDR). Read More

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http://dx.doi.org/10.1109/JBHI.2019.2899403DOI Listing
February 2019

Lessons from glaucoma: rethinking the fluid-brain barriers in common neurodegenerative disorders.

Neural Regen Res 2019 Jun;14(6):962-966

Department of Surgery, Faculty of Medicine, University of Granada, Granada, Spain.

Glaucoma has been recently characterized as a member of the group of anoikis-related diseases. Anoikis, a form of apoptosis, can be triggered by the unfastening of adherent junctions present in astrocytes. In those areas of the central nervous system in which the soma of the neurons or their axons and dendrites are metabolically dependent on the activity of astrocytes, a derangement of the lactate shuttle caused by a separation between the plasma membranes of neurons and astrocytes would result in metabolic impairment of the neurons themselves. Read More

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http://www.nrronline.org/text.asp?2019/14/6/962/249215
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http://dx.doi.org/10.4103/1673-5374.249215DOI Listing
June 2019
1 Read

Evaluation of the retinal nerve fiber layer and ganglion cell complex thicknesses in patients with exfoliation syndrome

Turk J Med Sci 2019 Feb 11;49(1):272-278. Epub 2019 Feb 11.

Background/aim: This study aimed to evaluate retinal nerve fiber layer (RNFL) and ganglion cell complex (GCC) thicknesses using spectral domain optical coherence tomography (SD-OCT) in both unilateral and bilateral exfoliation syndrome (XFS) patients

Materials And Methods: Twenty-four patients with unilateral XFS, 20 patients with bilateral XFS, and 23 healthy subjects were enrolled in this study. Eyes with XFS were compared with both fellow eyes and age-matched control subject eyes in terms of mean and segmental RNFL thickness and minimum, mean, and segmental GCC thickness.

Results: In the bilateral XFS group, minimum GCC of the right eye (75. Read More

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http://dx.doi.org/10.3906/sag-1803-27DOI Listing
February 2019

Traumatic eye injury from an exploding aerosol can.

Med J Aust 2019 Feb 13. Epub 2019 Feb 13.

Royal Victorian Eye and Ear Hospital, Melbourne, VIC.

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http://dx.doi.org/10.5694/mja2.50009DOI Listing
February 2019

Migraine and increased risk of developing open angle glaucoma: a population-based cohort study.

BMC Ophthalmol 2019 Feb 13;19(1):50. Epub 2019 Feb 13.

Department of Ophthalmology, National Taiwan University Hospital, Hsin-Chu Branch, Hsin-Chu, Taiwan.

Background: Migraine is linked to endothelial dysfunction and is considered to be a systemic vasculopathy. Interestingly, systemic vascular diseases also occur in glaucoma patients and are considered to be vascular risk factors. Whether migraine is simply a concomitant condition in glaucoma patients or a risk factor per se for glaucoma remains unknown. Read More

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http://dx.doi.org/10.1186/s12886-019-1062-9DOI Listing
February 2019

Two-year results of a multicenter study of the ab interno gelatin implant in medically uncontrolled primary open-angle glaucoma.

Graefes Arch Clin Exp Ophthalmol 2019 Feb 13. Epub 2019 Feb 13.

Department of Ophthalmology, University Hospitals UZ Leuven, Leuven, Belgium.

Purpose: To evaluate the effectiveness of an ab interno subconjunctival gelatin implant as primary surgical intervention in reducing intraocular pressure (IOP) and IOP-lowering medication count in medically uncontrolled moderate primary open-angle glaucoma (POAG).

Methods: In this prospective, non-randomized, open-label, multicenter, 2-year study, eyes with medicated baseline IOP 18-33 mmHg on 1-4 topical medications were implanted with (phaco + implant) or without (implant alone) phacoemulsification. Changes in mean IOP and medication count at months 12 (primary outcomes) and 24, clinical success rate (eyes [%] achieving ≥ 20% IOP reduction from baseline on the same or fewer medications without glaucoma-related secondary surgical intervention), intraoperative complications, and postoperative adverse events were assessed. Read More

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http://dx.doi.org/10.1007/s00417-019-04251-zDOI Listing
February 2019

Evaluation of Antiglaucomatous Drops on Conjunctival Thickness in Patients with Primary Open-Angle Glaucoma.

J Ocul Pharmacol Ther 2019 Feb 13. Epub 2019 Feb 13.

Department of Ophthalmology, Faculty of Medicine, Yuzuncu Yil University, Van, Turkey.

Purpose: To determine the effects of antiglaucomatous drops on the conjunctival thickness.

Methods: Between March 2018 and May 2018, conjunctival thicknesses (epithelium + stroma) were measured with anterior segment OCT in 51 eyes of the control group and 49 eyes who had glaucoma diagnosis at the Van YYU Medical Faculty Ophthalmology Department and had been using antiglaucomatous drops for at least 6 months. At 12 o'clock direction, horizontal multisections were taken aiming at the conjunctiva 3-5 mm away from the limbus. Read More

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http://dx.doi.org/10.1089/jop.2018.0124DOI Listing
February 2019

Glaucoma Detection from Retinal Images Using Statistical and Textural Wavelet Features.

J Digit Imaging 2019 Feb 12. Epub 2019 Feb 12.

Electronics & Communications Department, Faculty of Engineering, Misr International University, Cairo, Egypt.

Glaucoma is a silent progressive eye disease that is among the leading causes of irreversible blindness. Early detection and proper treatment of glaucoma can limit severe vision impairments associated with advanced stages of the disease. Periodic automatic screening can help in the early detection of glaucoma while reducing the workload on expert ophthalmologists. Read More

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http://dx.doi.org/10.1007/s10278-019-00189-0DOI Listing
February 2019

Fisetin rescues retinal functions by suppressing inflammatory response in a DBA/2J mouse model of glaucoma.

Doc Ophthalmol 2019 Feb 11. Epub 2019 Feb 11.

Department of Ophthalmology, People's Hospital of Rizhao, No. 126 Tai'an Road, Donggang District, Rizhao, 276800, Shandong, China.

Purpose: Glaucoma is a common chronic neurodegenerative disease, which could lead to visual loss. In this study, we aimed to investigate whether fisetin, a natural flavone with anti-inflammatory and antioxidant properties, is able to alleviate glaucoma.

Methods: We employed a DBA/2J mouse model which was treated with or without fisetin. Read More

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http://dx.doi.org/10.1007/s10633-019-09676-9DOI Listing
February 2019

Stroke Mimic Caused by Acetazolamide.

Eur J Case Rep Intern Med 2018 25;5(5):000822. Epub 2018 May 25.

Department of Medicine, Unidade Local de Saude do Alto Minho, Hospital Conde de Bertiandos, Ponte do Lima, Portugal.

Objectives: To describe a case of a stroke mimic caused by iatrogenic ataxia due to acetazolamide.

Case Description: An 86-year-old man with a history of gout and glaucoma, presented to the emergency department with progressive confusion, dizziness, disequilibrium and slurred speech, 3 days after he had started acetazolamide following ocular surgery. Physical examination showed he was hypertensive and had dysarthria; it was not possible to observe his gait due to pain in the right foot presumed to be due to a gout crisis. Read More

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http://dx.doi.org/10.12890/2018_000822DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346928PMC

Absence of Posterior Vitreous Detachment Is a Risk Factor of Severe Bleb-Related Endophthalmitis.

J Ophthalmol 2019 14;2019:1585830. Epub 2019 Jan 14.

Department of Ophthalmology, Tokyo Medical University, Tokyo, Japan.

Purpose: Bleb-related endophthalmitis (BRE) after glaucoma surgery is an infection caused by bacteria in the avascular bleb gaining access into the eye. We report the clinical features and outcome of 10 consecutive eyes with severe BRE treated at our hospital.

Methods: Ten patients (10 eyes) with stage IIIb BRE after trabeculectomy diagnosed and treated at the Department of Ophthalmology, Tokyo Medical University, between April 2013 and May 2015, were studied. Read More

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http://dx.doi.org/10.1155/2019/1585830DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348893PMC
January 2019

Numerical model of aqueous humor drainage: effects of collector channel position.

Med Eng Phys 2019 Feb 9. Epub 2019 Feb 9.

North Central Hospital PEMEX, Marina Nacional No. 329, Col. Petroleos Mexicanos, C.P. 11311, Ciudad de Mexico.

Glaucoma is a progressive and a degenerative eye disease that gradually deteriorates the vision. The origin of glaucoma is still under debate. Recent studies report that 50% of the aqueous humor outflow resistance resides on collector channels and Schlemm's canal (SC). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S13504533193001
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http://dx.doi.org/10.1016/j.medengphy.2018.12.022DOI Listing
February 2019
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Micropulse Transscleral Cyclophotocoagulation in Keratoplasty Eyes.

Cornea 2019 Feb 6. Epub 2019 Feb 6.

Price Vision Group, Indianapolis, IN.

Purpose: To assess the outcomes of micropulse transscleral cyclophotocoagulation for intraocular pressure (IOP) control in keratoplasty eyes.

Methods: Outcomes of micropulse laser treatments of postkeratoplasty eyes were retrospectively reviewed. IOP was assessed with applanation tonometry. Read More

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http://dx.doi.org/10.1097/ICO.0000000000001897DOI Listing
February 2019

How to Predict Intraocular Pressure Reduction after Cataract Surgery? A Prospective Study.

Curr Eye Res 2019 Feb 12. Epub 2019 Feb 12.

a Department of Ophthalmology , University of California , San Francisco , CA , USA.

Purpose/Aim: To evaluate the best formula to predict intraocular pressure (IOP) reduction after cataract surgery.

Materials And Methods: Prospective longitudinal study. We included consecutive patients with or without glaucoma, either with open or narrow angles but without peripheral anterior synechiae, who underwent phacoemulsification. Read More

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http://dx.doi.org/10.1080/02713683.2019.1580375DOI Listing
February 2019

Bilateral Acute Angle-Closure Glaucoma after Macular Hole Surgery.

Korean J Ophthalmol 2019 Feb;33(1):101-102

Department of Ophthalmology, Keimyung University School of Medicine, Daegu, Korea.

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http://dx.doi.org/10.3341/kjo.2018.0061DOI Listing
February 2019

Evaluation and Management of the Emergency Department Headache.

Semin Neurol 2019 Feb 11;39(1):20-26. Epub 2019 Feb 11.

Department of Emergency Medicine, Maricopa Medical Center, Phoenix, Arizona.

The acute headache in the emergency department (ED) poses a diagnostic dilemma that may overwhelm providers attempting to weigh the cost of advanced workups against the risk of missing serious pathology. While the majority of headache concerns are benign primary headache disorders, identifying life-threatening secondary causes of headache-which may be broadly categorized into structural, infectious, and vascular causes-is the primary focus of evaluation in the ED. Secondary headaches are associated with a high morbidity and mortality, and require strict scrutiny of the history and physical examination to adequately risk-stratify patients. Read More

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http://dx.doi.org/10.1055/s-0038-1677023DOI Listing
February 2019
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Investigation of inhibitory properties of some hydrazone compounds on hCA I, hCA II and AChE enzymes.

Bioorg Chem 2019 Feb 4;86:316-321. Epub 2019 Feb 4.

Neurofarba Department, Section of Pharmaceutical and Nutriceutical Sciences, Universita degli Studi di Firenze, Florence, Italy.

Recently, inhibition of carbonic anhydrase (hCA) and acetylcholinesterase (AChE) have appeared as a promising approach for pharmacological intervention in a variety of disorders such as glaucoma, epilepsy, obesity, cancer, and Alzheimer's disease. Keeping this in mind, N,N'-bis[(1-aryl-3-heteroaryl)propylidene]hydrazine dihydrochlorides, N1-N11, P1, P4-P8, and R1-R6, were synthesized to investigate their inhibitory activity against hCA I, hCA II, and AChE enzymes. All compounds in N, P, and R-series inhibited hCAs (I and II) and AChE more efficiently than the reference compounds acetazolamide (AZA), and tacrine. Read More

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http://dx.doi.org/10.1016/j.bioorg.2019.02.008DOI Listing
February 2019
2.152 Impact Factor

Staged ocular fornix reconstruction for glaucoma drainage device under neoconjunctiva at the time of Boston type 1 Keratoprosthesis implantation.

Ocul Surf 2019 Feb 8. Epub 2019 Feb 8.

Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, IL, United States.

Purpose: Glaucoma is the leading cause of vision loss in eyes with Boston Keratoprosthesis (KPro). Glaucoma drainage devices (GDDs) have been shown to be effective in controlling glaucoma with KPro. Cicatricial conjunctival disease with forniceal shortening is a major challenge and limitation to the use of GDD. Read More

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http://dx.doi.org/10.1016/j.jtos.2019.01.010DOI Listing
February 2019

Lamina Cribrosa Curvature in Healthy Korean Eyes.

Sci Rep 2019 Feb 11;9(1):1756. Epub 2019 Feb 11.

Université de la Polynésie française, Tahiti, French Polynesia.

Given that posterior bowing of the lamina cribrosa (LC) is a principle event in the development of glaucomatous damage, assessment of the LC morphology may have clinical utility in diagnosing and managing glaucoma patients. LC curvature has been suggested as an index to evaluate the LC morphology. To apply LC morphology in clinical practice, it is necessary to know normal profiles of LC curvature in healthy population. Read More

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http://dx.doi.org/10.1038/s41598-018-38331-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6370828PMC
February 2019