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BMJ Case Rep 2021 Jun 15;14(6). Epub 2021 Jun 15.

Ophthalmology, Royal Liverpool and Broadgreen Hospitals NHS Trust, Liverpool, UK

A 78-year-old pseudophakic women with pseudoexfoliation glaucoma and 6-year history of prior Descemet's stripping automated endothelial keratoplasty (DSAEK) underwent deep sclerectomy for a poorly controlled glaucoma. Exposure of the trabeculo-Descemet's window (TDW), showed a very poor drainage. An attempt to dissect the fibrous tissue off the TDW resulted in perforation of the window needing peripheral iridectomy, followed by a white fibrous band which had to be excised to prevent blockade of the filtration channel. Read More

J Pak Med Assoc 2021 Apr;71(4):1100-1102

Department of Ophthalmology, LRBT Free Eye Care Hospital, Shahpur, Pakistan.

Objective: To measure the mean change of intraocular pressure in glaucoma patients with cataract after uncomplicated phacoemulsification surgery with intraocular lens implanted in capsular bag.

Methods: The quasi-experimental study was conducted at the Ophthalmology Department of Pakistan Institute of Medical Sciences Shaheed Zulfiqar Ali Bhutto Medical University, Islamabad, Pakistan, from June 11 to December 10, 2018, and comprised patients who had uncomplicated cataract extraction by phacoemulsification with intraocular lens implant in the capsular bag in glaucomatous eyes of age 30-80 years. Visual acuity, intraocular pressure, slit lamp examination, fundoscopy, visual fields, details about topical medication and relevant history were recorded not more than 5 days before cataract extraction. Read More

BMC Ophthalmol 2021 Jun 10;21(1):257. Epub 2021 Jun 10.

Department of Ophthalmology, Shimane University Faculty of Medicine, 89-1 Enya-cho, Izumo, Shimane, 693-8501, Japan.

Background: We report a case of chronic retinal necrosis (CRN) combined with cytomegalovirus (CMV) corneal endotheliitis.

Case Presentation: An 80-year old man was diagnosed with CRN that developed after tube shunt surgery with vitrectomy for secondary glaucoma associated with CMV corneal endotheliitis. After the use of oral valganciclovir and panretinal photocoagulation, the retinal lesion resolved rapidly and he has maintained visual acuity better than before the onset of CRN. Read More

BMC Ophthalmol 2021 Jun 7;21(1):253. Epub 2021 Jun 7.

Department of Ophthalmology, Hanyang University College of Medicine, Seoul, Korea.

Background: Disc hemorrhage (DH) is an important factor often associated with the development and especially progression of glaucoma. In contrast, some studies have reported peripapillary retinoschisis in glaucoma, but it is not recognized as a pathognomonic finding, and opinions on the clinical significance of retinoschisis are not consistent. Here,we present the case of DH following peripapillary retinoschisis in the same area within the same glaucomatous eye. Read More

BMC Public Health 2021 06 4;21(1):1065. Epub 2021 Jun 4.

School of Public Health, Fudan University, Shanghai, 200433, China.

Background: Population-based screening was essential for glaucoma management. Although various studies have investigated the cost-effectiveness of glaucoma screening, policymakers facing with uncontrollably growing total health expenses were deeply concerned about the potential financial consequences of glaucoma screening. This present study was aimed to explore the impact of glaucoma screening with artificial intelligence (AI) automated diagnosis from a budgetary standpoint in Changjiang county, China. Read More

Medicine (Baltimore) 2021 Jun;100(22):e26232

Department of Ophthalmology, Keio University School of Medicine.

Rationale: Metastasis of neoplasms to the eye is quite uncommon. In this case report, we describe a patient where primary esophageal cancer was diagnosed by fine needle aspiration biopsy (FNAB) of an iris tumor.

Patient Concerns: A 70-year-old male complained of redness and discomfort in the right eye. Read More

Pharmaceuticals (Basel) 2021 May 24;14(6). Epub 2021 May 24.

Department of Ophthalmology, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul 03722, Korea.

In this study, we investigated the effect of preservative-free (PF) 0.0015% tafluprost (TA), to the preservative containing (PC) and the PF 0.005% latanoprost (LA) in Korean subjects. Read More

Int J Mol Sci 2021 May 18;22(10). Epub 2021 May 18.

Department of Ophthalmology, University of Münster Medical School, 48149 Münster, Germany.

The WWC protein family is an upstream regulator of the Hippo signalling pathway that is involved in many cellular processes. We examined the effect of an endothelium-specific WWC1 and/or WWC2 knock-out on ocular angiogenesis. Knock-outs were induced in C57BL/6 mice at the age of one day (P1) and evaluated at P6 (postnatal mice) or induced at the age of five weeks and evaluated at three months of age (adult mice). Read More

Sensors (Basel) 2021 May 14;21(10). Epub 2021 May 14.

Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.

Understanding periods of the year associated with higher risk for falling and less physical activity may guide fall prevention and activity promotion for older adults. We examined the relationship between weather and seasons on falls and physical activity in a three-year cohort of older adults with glaucoma. Participants recorded falls information via monthly calendars and participated in four one-week accelerometer trials (baseline and per study year). Read More

Indian J Ophthalmol 2021 Jun;69(6):1623-1625

C L Gupta Eye Institute, Ram Ganga Vihar Phase 2 (Ext.), Moradabad, Uttar Pradesh, India.

We describe a case of 63-year-old woman, with primary open-angle glaucoma (POAG) who presented to us in the COVID era with uncontrolled intraocular pressure (IOP) on maximum medical therapy (MMT) in the right eye (OD), previously operated twice for trabeculectomy in (OD), and once in left eye (OS). A modified graft-free surgical technique of inserting the Ahmed Glaucoma valve (AGV) tube through a scleral sleeve was employed. Visual acuity and IOP remained stable during 6-month follow-up period. Read More

Indian J Ophthalmol 2021 06;69(6):1418-1424

Biostatistician, Sathyan Eye Care Hospital and Coimbatore Glaucoma Foundation, Coimbatore, Tamil Nadu, India.

Purpose: To understand the factors that explain compliance to anti-glaucoma medication (AGM) in terms of application,purchase, stocking and compliance behaviour.

Methods: This was a cross-sectional study conducted in the outpatient department of an urban tertiary eye care center in South India. Interviews were completed with consenting, consecutive, literate primary glaucoma patients. Read More

Medicine (Baltimore) 2021 May;100(20):e25828

Xiamen University Affiliated Xiamen Eye Center, Xiamen.

Objective: The aim of this study was to determine the best thickness of corneal slices acquired from femtosecond laser surgery-small incision lenticule extraction (SMILE surgery) as patch graft in glaucoma drainage implantation surgery.

Methods: This study is a prospective randomized study. Patients who received glaucoma drainage implantation from September 2016 to November 2018 were observed. Read More

BMJ 2021 05 12;373:n1014. Epub 2021 May 12.

Centre for Healthcare Randomised Trials (CHaRT), Health Services Research Unit, University of Aberdeen, UK.

Objective: To determine whether primary trabeculectomy or primary medical treatment produces better outcomes in term of quality of life, clinical effectiveness, and safety in patients presenting with advanced glaucoma.

Design: Pragmatic multicentre randomised controlled trial.

Setting: 27 secondary care glaucoma departments in the UK. Read More

BMJ Case Rep 2021 May 10;14(5). Epub 2021 May 10.

Department of Immunology, Canberra Health Services, Garran, Australian Capital Territory, Australia.

Hypocomplementemic urticarial vasculitis syndrome (HUVS) is a rare autoimmune disorder characterised by recurrent urticarial lesions and acquired hypocomplementemia with systemic manifestations. The authors present the case of a 70-year-old man who presented to the ophthalmology clinic with bilateral scleritis and ocular hypertension. He was diagnosed with HUVS after a 6-month period of bilateral scleritis, vestibulitis, significant weight loss, mononeuritis multiplex and recurrent urticarial vasculitis with pronounced persistent hypocomplementemia and the presence of anti-C1q antibodies. Read More

J Med Case Rep 2021 May 5;15(1):237. Epub 2021 May 5.

Department of Gastroenterological Surgery, Kawasaki Saiwai Hospital, 31-27 Omiyacho, Saiwai-ku, Kawasaki city, Kanagawa, 212-0014, Japan.

Introduction: Primary malignant melanoma of the esophagus is a rare and aggressive disease that tends to have a poor response to chemotherapies. Previous studies have indicated that currently available treatment for primary malignant melanoma of the esophagus is insufficient. Here, we describe a case of recurrent primary malignant melanoma of the esophagus successfully treated with the immune checkpoint inhibitor nivolumab. Read More

Klin Monbl Augenheilkd 2021 Apr 30;238(4):391-395. Epub 2021 Apr 30.

Augenklinik, Luzerner Kantonsspital, Luzern, Switzerland.

Purpose: To evaluate the outcome of gonioscopy-assisted transluminal trabeculotomy (GATT) in patients with open-angle glaucoma (OAG).

Participants And Methods: A retrospective case series of patients with uncontrolled OAG treated by GATT at the cantonal Hospital Lucerne, a tertiary referral center, between October 2018 and July 2019 with a minimal 6-month follow-up period. Main outcome measures were intraocular pressure (IOP), number of antiglaucoma medications, and complications. Read More

Indian J Ophthalmol 2021 May;69(5):1271-1274

Department of Vitreo-Retina, Regional Institute of Ophthalmology, Minto Ophthalmic Hospital, BMCRI, Bengaluru, Karnataka, India.

Purpose: The aim of this work was to study and document retinal changes in coronavirus disease-2019 (COVID-19) positive patients with nonsevere disease using a nonmydriatic handheld fundus camera.

Methods: A cross-sectional observational study was conducted on patients affected by COVID-19 who were admitted at our center. Our study included patients with no, mild, and moderate symptoms (nonsevere cases). Read More

Eur J Ophthalmol 2021 Apr;31(1_suppl):16-19

Health Education KSS, East Surrey Hospital, Redhill, UK.

Introduction: Minimally invasive glaucoma surgery (MIGS) is a relatively new surgical technique available to glaucoma surgeons. The ab interno gelatin XEN stent (XEN®45, Allergan Inc., CA, USA) drains aqueous into the subconjunctival space and is theoretically less invasive than trabeculectomy and therefore carries less risk. Read More

JAMA Neurol 2021 Jun;78(6):718-725

Department of Ophthalmology, Emory University School of Medicine, Atlanta, Georgia.

Importance: Magnetic resonance imaging (MRI) signs of intracranial hypertension (IH) are traditionally associated with idiopathic intracranial hypertension (IIH), but these signs are also detected among individuals with primary headaches and among asymptomatic individuals without papilledema.

Objective: To examine the prevalence of MRI signs of IH among consecutive outpatients undergoing brain MRI for any clinical indication and to explore their association with papilledema.

Design, Setting, And Participants: This prospective cross-sectional study of outpatients undergoing brain MRI at 1 outpatient imaging facility was conducted between August 1, 2019, and March 31, 2020, with ocular fundus photographs taken concurrently. Read More

BMJ Case Rep 2021 Apr 15;14(4). Epub 2021 Apr 15.

Vitreoretina Services, LV Prasad Eye Institute, Bhubaneswar, Odisha, India.

Siderotic glaucoma is a rare and challenging clinical scenario caused by a retained iron intraocular foreign body (IOFB), which results in irreversible vision loss. Presented here is a case of secondary open-angle glaucoma in a 36-year-old man that was refractory to maximal medical therapy. A meticulous history and careful clinical examination revealed that he had a penetrating trauma 15 years ago, a self-sealed corneal entry wound, open angles, a retained encapsulated metallic IOFB and siderosis bulbi. Read More

Optom Vis Sci 2021 04;98(4):362-366

Department of Primary Care, New England College of Optometry, Boston, Massachusetts.

Significance: The eye care needs of the homeless population in the United States are not well known. This study elucidates those needs for health care for the homeless programs and eye care practitioners. This information could result in an increase in the provision of necessary eye care services. Read More

Medicine (Baltimore) 2021 Apr;100(14):e24673

Department of Ophthalmology, Korea University College of Medicine, Seoul, Korea.

Abstract: Objective of the study was to investigate the effects of peripheral anterior synechiae (PAS) on refractive outcomes after cataract surgery in eyes with primary angle-closure disease (PACD).This is a retrospective, cross-sectional study. Seventy eyes of 70 PACD patients who underwent phacoemulsification and intraocular lens implantation. Read More

BMJ Open 2021 04 5;11(4):e043130. Epub 2021 Apr 5.

Division of Optometry and Visual Sciences, School of Health Sciences, City, University of London, London, UK.

Objectives: To explore the acceptability of home visual field (VF) testing using Eyecatcher among people with glaucoma participating in a 6-month home monitoring pilot study.

Design: Qualitative study using face-to-face semistructured interviews. Transcripts were analysed using thematic analysis. Read More

Middle East Afr J Ophthalmol 2020 Oct-Dec;27(4):241-243. Epub 2021 Jan 19.

Department of Ophthalmology, College of Medicine, King Saud University, Riyadh, Kingdom of Saudi Arabia.

Annular ciliochoroidal effusion is a rare condition that can complicate trabeculectomy. We report a case of ciliochoroidal effusion mimicking aqueous misdirection after combined glaucoma and cataract surgery. A 75-year-old male with pseudoexfoliation, chronic angle-closure glaucoma, and advanced optic disc damage developed ciliochoroidal effusion after a combined trabeculectomy and phacoemulsification with intraocular lens implantation. Read More

Middle East Afr J Ophthalmol 2020 Oct-Dec;27(4):224-227. Epub 2021 Jan 19.

Department of Ophthalmology, Dr. Shroff's Charity Eye Hospital, New Delhi, India.

Purpose: The purpose of the study was to report a small case series of patients with iridoschisis seen at our hospital over a period of 5 years.

Methods: Retrospective review of all those files over the past 5 years whereby the diagnosis of iridoschisis/iris atrophy/iris fibrils in anterior chamber (AC) was made.

Results: In our case series, the average age at presentation was 49 years (range: 23-85 years). Read More

F1000Res 2020 14;9:1236. Epub 2020 Oct 14.

Department of Ophthalmology, School of Medicine, University Hospital Wuerzburg, 97080, Germany.

Neovascular glaucoma (NVG) is a severe, potentially blinding disease and a therapeutic challenge. The purpose of this study was to evaluate the safety and efficacy of an integrative surgical approach to neovascular glaucoma. Retrospective analysis of a one-year follow-up of a consecutive interventional case series of NVG. Read More

Cells 2021 Mar 4;10(3). Epub 2021 Mar 4.

Department of Ophthalmology and Visual Science, University of Chicago Medical Center, Chicago, IL 60637, USA.

This is a cross-sectional, prospective study of a population of black diabetic participants without diabetic retinopathy aimed to investigate optical coherence tomography angiography (OCTA) characteristics and correlations with systemic diseases in this population. These parameters could serve as novel biomarkers for microvascular complications; especially in black populations which are more vulnerable to diabetic microvascular complications. Linear mixed models were used to obtain OCTA mean values ± standard deviation and analyze statistical correlations to systemic diseases. Read More

Medicina (Kaunas) 2021 Mar 3;57(3). Epub 2021 Mar 3.

Health Telematics Science Institute, Kaunas University of Technology, K. Barsausko Str. 59-A557, LT-51423 Kaunas, Lithuania.

Ventriculoperitoneal shunt placement is the most commonly used treatment of normal-pressure hydrocephalus (NPH). It has been hypothesized that normal-tension glaucoma (NTG) is caused by the treatment of NPH by using the shunt to reduce intracranial pressure (ICP). The aim of this study is to review the literature published regarding this hypothesis and to emphasize the need for neuro-ophthalmic follow-up for the concerned patients. Read More

Obes Facts 2021 1;14(2):169-177. Epub 2021 Apr 1.

Department of Experimental Medicine, University of Campania "Luigi Vanvitelli", Naples, Italy.

Introduction: Several studies in the adult population have shown that obesity is an independent risk factor for elevated intraocular pressure (IOP), whereas data in the paediatric population are sparse and controversial. The purpose of the present study is to investigate the relationship between body mass index (BMI), blood pressure (BP), and IOP in healthy school children.

Methods: The survey was conducted among a random sample of 8-year-old Italian students. Read More

Ophthalmology 2021 Mar 27. Epub 2021 Mar 27.

Department of Ophthalmology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania. Electronic address:

Purpose: Certain systemic conditions are reported to be risk factors for dry eye disease (DED), but their associations with DED severity are not well studied. We evaluated whether systemic conditions reported to be DED risk factors are associated with severity of DED signs and symptoms.

Design: Secondary analysis of data from the Dry Eye Assessment and Management Study, a large-scale multicenter randomized clinical trial of patients with moderate to severe DED. Read More