30,873 results match your criteria Glaucoma Suspect Adult


Changes of retinal and choroidal capillary blood flow in macula after an acute intraocular pressure elevation.

Medicine (Baltimore) 2020 Jun;99(26):e21007

Department of Ophthalmology, the First People's Hospital of Huzhou, Huzhou, Zhejiang Province, China.

The aim of this study was to investigate the changes of retinal vessel density (VD) and choriocapillary blood flow area (CBFA) in macula after an acute intraocular pressure (IOP) elevation observed using optical coherence tomography angiography.This was a prospective comparative study of subjects with narrow anterior chamber angles who underwent laser peripheral iridotomies (LPIs). The IOP was measured before and 1 hour after the LPI. Read More

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http://dx.doi.org/10.1097/MD.0000000000021007DOI Listing

Outcome of Selective Laser Trabeculoplasty in Young Patients with Primary Open-Angle Glaucoma and Ocular Hypertension.

J Ophthalmol 2020 9;2020:5742832. Epub 2020 Jun 9.

Eye Center of Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, China.

Purpose: To determine the effectiveness and safety of selective laser trabeculoplasty (SLT) in young patients with primary open-angle glaucoma (POAG) and ocular hypertension (OHT).

Methods: This was a retrospective clinical study. Fifty-six eyes from 56 young (age ≤ 40 y) patients with POAG or OHT treated with SLT were included. Read More

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http://dx.doi.org/10.1155/2020/5742832DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7301184PMC

Lack of correlation between S1 RNA binding domain 1 SNP rs3213787/rs11884064 and normal-tension glaucoma in a population from the Republic of Korea.

Medicine (Baltimore) 2020 Jun;99(25):e20066

Department of Ophthalmology, Uijeongbu St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.

Previous studies have reported the association of the S1 RNA binding domain 1 (SRBD1) gene with open-angle glaucoma in various ethnic populations. However, in those studies, the definition of the patients differed, as did the results. Therefore, the relevance of the SRBD1 gene to normal tension glaucoma (NTG) appears uncertain at present. Read More

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http://dx.doi.org/10.1097/MD.0000000000020066DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7310881PMC

Evaluation of Ophthalmology Inpatients Consultation in a Nigerian Tertiary Eye Care Centre.

West Afr J Med 2020 Jul-Aug;37(3):221-224

Department of Ophthalmology, University of Benin Teaching Hospital, Benin City, Nigeria.

Background: Ophthalmology consultations are more thorough on outpatient basis, but inpatient evaluation cannot be over looked especially in terms of care of patients admitted in other specialties.

Objectives: This is to assess the profile of inpatient consultation and eye problems evaluated and managed by the ophthalmology department of the University of Benin Teaching Hospital, Benin City, Nigeria.

Methods: All consecutive inpatients who had ophthalmic consultations requested for by various departments in the hospital between July 2018 and June 2019. Read More

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Short-Term Efficacy and Safety of Switching from a Latanoprost/Timolol Fixed Combination to a Latanoprost/Carteolol Fixed Combination.

Clin Ophthalmol 2020 4;14:1207-1214. Epub 2020 May 4.

Department of Ophthalmology, Toho University Ohashi Medical Center, Tokyo, Japan.

Purpose: To investigate the short-term intraocular pressure-lowering efficacy and safety of switching from a fixed combination of latanoprost/timolol to a fixed combination of latanoprost/carteolol.

Patients And Methods: The subjects were 30 eyes of 30 adult patients with primary open-angle glaucoma, normal-tension glaucoma, or ocular hypertension who were using a latanoprost-/timolol-fixed combination with insufficient intraocular pressure-lowering efficacy or adverse reactions. The subjects were switched from once-daily latanoprost/timolol to once-daily latanoprost/carteolol with no washout interval. Read More

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http://dx.doi.org/10.2147/OPTH.S240425DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7210024PMC

The effect of glaucoma treatment using high-intensity focused ultrasound on total and corneal astigmatism: a prospective multicentre study.

Acta Ophthalmol 2020 May 18. Epub 2020 May 18.

Department of Ophthalmology, Hospital de Santa Maria, Centro Hospitalar Universitário Lisboa Norte, Lisboa, Portugal.

Purpose: Ultrasound cycloplasty (UCP) acts through the selective coagulation of the ciliary body using high-intensity focused ultrasound (HIFU) technology. The aim of this study was to investigate whether the application of ultrasound beams targeting the ciliary body using an external probe influences astigmatism.

Methods: Multicentre, prospective, single-arm, open-label study in adult patients with primary open-angle glaucoma and moderately uncontrolled intraocular pressure (IOP) under glaucoma medication. Read More

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http://dx.doi.org/10.1111/aos.14467DOI Listing
May 2020
2.844 Impact Factor

Epidemiology of episcleritis and scleritis in urban Australia.

Clin Exp Ophthalmol 2020 Apr 12. Epub 2020 Apr 12.

Centre for Eye Research Australia, The Royal Victorian Eye and Ear Hospital, Melbourne, Victoria, Australia.

Importance: The epidemiology of episcleritis and scleritis in Australia is largely unknown.

Background: To determine the incidence, prevalence and clinical characteristics of episcleritis and scleritis in Melbourne.

Design: Retrospective longitudinal study. Read More

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http://dx.doi.org/10.1111/ceo.13761DOI Listing

[Spatial contrast sensitivity in patients with primary open-angle glaucoma and ocular hypertension].

Vestn Oftalmol 2020 ;136(1):25-35

Chelyabinsk Regional Clinical Hospital No. 3, 287 Pobedy av., Chelyabinsk, Russian Federation, 454021.

Up to now, there has not been a comparison of spatial contrast sensitivity (SCS) in patients with primary and pseudoexfoliation open-angle glaucoma (POAG; PEG) and ophthalmic hypertension (OH).

Purpose: To study the characteristics of SCS in patients with POAG, PEG (as well as in the paired eye without glaucoma) and OH.

Material And Methods: The work was performed in the period from 2011 to July 2017. Read More

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http://dx.doi.org/10.17116/oftalma202013601125DOI Listing

The use of telemedicine to support Brazilian primary care physicians in managing eye conditions: The TeleOftalmo Project.

PLoS One 2020 2;15(4):e0231034. Epub 2020 Apr 2.

Faculdade de Medicina, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil.

Purpose: To determine whether teleophthalmology can help physicians in assessing and managing eye conditions and to ascertain which clinical conditions can be addressed by teleophthalmology in primary care setting.

Methods: We evaluated the resolution capacity of TeleOftalmo, strategy implemented in the public health system of southern Brazil. Resolution capacity was defined as the ability to fully address patients' eye complaints in primary care with remote assistance from ophthalmologists. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0231034PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7117761PMC

Evaluation of Fear of Falling in Patients with Primary Open-Angle Glaucoma and the Importance of Inferior Visual Field Damage.

Invest Ophthalmol Vis Sci 2020 03;61(3):52

,.

Purpose: To evaluate fear of falling using the Fall Efficacy Scale-International (FES-I) in glaucoma patients and investigate its association with glaucomatous visual field loss.

Methods: This study included 273 patients (160 men and 113 women, average age 64.2 years) with primary open-angle glaucoma. Read More

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http://dx.doi.org/10.1167/iovs.61.3.52DOI Listing

Normal tension glaucoma in obstructive sleep apnea syndrome: A structural and functional study.

Medicine (Baltimore) 2020 Mar;99(13):e19468

College of Medicine, Chang Gung University, Taoyuan.

This study characterized and evaluated normal tension glaucoma (NTG) in obstructive sleep apnea syndrome (OSAS).In this retrospective, cross-sectional study, all participants were examined with polysomnography (PSG). Functional parameters of standard automated perimetry (SAP) were recorded. Read More

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http://dx.doi.org/10.1097/MD.0000000000019468DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7220748PMC

Automated Evaluation of Parapapillary Choroidal Microvasculature in Ischemic Optic Neuropathy and Open Angle Glaucoma.

Invest Ophthalmol Vis Sci 2020 03;61(3):35

,.

Purpose: To determine whether parapapillary choroidal microvasculature (PPCMv) density as measured by optical coherence tomography angiography differs between nonarteritic anterior ischemic optic neuropathy (NAION) and primary open angle glaucoma (POAG).

Methods: Thirty-seven eyes with chronic NAION, 34 unaffected fellow eyes with NAION, 47 moderate and severe POAG eyes, and 54 healthy control subjects were evaluated. Automated PPCMv density was calculated using custom Matlab software in inner and outer annuli around the optic nerve region in addition to peripapillary superficial retinal vessels. Read More

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http://dx.doi.org/10.1167/iovs.61.3.35DOI Listing

Gait and Balance as Predictors and/or Mediators of Falls in Glaucoma.

Invest Ophthalmol Vis Sci 2020 03;61(3):30

.

Purpose: To investigate the association between balance and gait measures with fall rates in glaucoma patients.

Methods: Balance and gait were measured for 239 participants with glaucoma or suspected glaucoma. Daily falls were evaluated over 24 months. Read More

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http://dx.doi.org/10.1167/iovs.61.3.30DOI Listing

In Vivo Measurements of Prelamina and Lamina Cribrosa Biomechanical Properties in Humans.

Invest Ophthalmol Vis Sci 2020 03;61(3):27

.

Purpose: To develop and use a custom virtual fields method (VFM) to assess the biomechanical properties of human prelamina and lamina cribrosa (LC) in vivo.

Methods: Clinical data of 20 healthy, 20 ocular hypertensive (OHT), 20 primary open-angle glaucoma, and 16 primary angle-closure glaucoma eyes were analyzed. For each eye, the intraocular pressure (IOP) and optical coherence tomography (OCT) images of the optic nerve head (ONH) were acquired at the normal state and after acute IOP elevation. Read More

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http://dx.doi.org/10.1167/iovs.61.3.27DOI Listing
March 2020
3.404 Impact Factor

TGFβ2-Hepcidin Feed-Forward Loop in the Trabecular Meshwork Implicates Iron in Glaucomatous Pathology.

Invest Ophthalmol Vis Sci 2020 03;61(3):24

,.

Purpose: Elevated levels of transforming-growth-factor (TGF)-β2 in the trabecular meshwork (TM) and aqueous humor are associated with primary open-angle glaucoma (POAG). The underlying mechanism includes alteration of extracellular matrix homeostasis through Smad-dependent and independent signaling. Smad4, an essential co-Smad, upregulates hepcidin, the master regulator of iron homeostasis. Read More

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http://dx.doi.org/10.1167/iovs.61.3.24DOI Listing

Characteristics of Focal Gamma Zone Parapapillary Atrophy.

Invest Ophthalmol Vis Sci 2020 03;61(3):17

,.

Purpose: The purpose of this study was to investigate the characteristics of focal γ-zone parapapillary atrophy (focal γPPA) in patients with primary open-angle glaucoma (POAG) using spectral-domain optical coherence tomography (SD-OCT).

Methods: Three groups of POAG eyes (n = 214) were defined according to the circumferential extent of Bruch's membrane (BM) within the β-zone PPA, as follows: (1) no γPPA (intact BM; n = 81), (2) conventional γPPA (γPPA involving the fovea-BM-opening axis; n = 89), and (3) focal γPPA (γPPA not involving the fovea-BM-opening axis; n = 44). Clinical and ocular characteristics, including age, axial length (AXL), and focal lamina cribrosa (LC) defects were compared among the three groups. Read More

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http://dx.doi.org/10.1167/iovs.61.3.17DOI Listing

Protection of the Retinal Ganglion Cells: Intravitreal Injection of Resveratrol in Mouse Model of Ocular Hypertension.

Invest Ophthalmol Vis Sci 2020 03;61(3):13

,.

Purpose: To investigate the efficacy of intravitreal administration of resveratrol (RSV) in a microbead-induced high intraocular pressure (IOP) murine model for glaucoma.

Methods: Experiments were performed using adult C57BL/6JJcl mice. Polystyrene microbeads were injected into the anterior chamber to induce IOP elevation. Read More

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http://dx.doi.org/10.1167/iovs.61.3.13DOI Listing

Naringin protects against Bisphenol-A induced oculopathy as implication of cataract in hypertensive rat model.

Biomed Pharmacother 2020 Jun 13;126:110043. Epub 2020 Mar 13.

Cancer Research and Molecular Biology Laboratories, Department of Biochemistry, Faculty of Basic Medical Sciences, College of Medicine, University of Ibadan, Nigeria.

People who have experienced high blood pressure are at greater risk of susceptibility to other health problems including oculopathy. The patients with these experiences do not have adequate treatment and those who do; spend much funds on the drug purchase. The study examines the protective effect of naringin (NRG) against ocular impairment in -NAME induced hypertensive rat on exposure to a cellular disruptor. Read More

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http://dx.doi.org/10.1016/j.biopha.2020.110043DOI Listing

Mood and behavior seasonality in glaucoma; assessing correlations between seasonality and structure and function of the retinal ganglion cells.

PLoS One 2020 12;15(3):e0229991. Epub 2020 Mar 12.

Mental Health Services, Capital Region of Denmark, Copenhagen, Denmark.

Aim: In glaucoma, depression and disturbed sleep has been associated with degeneration of the intrinsically photosensitive retinal ganglion cells, that mediate non-image forming effects of light such as regulation of circadian rhythm, alertness and mood. In this study we assessed associations between seasonal mood and behavior variation and retinal ganglion cell damage in outpatients with glaucoma.

Methods: The seasonal pattern assessment questionnaire was administered to outpatients with glaucoma. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0229991PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7067444PMC

Coexistence of papilledema and pseudopapilledema after remission of idiopathic intracranial hypertension by bariatric surgery.

Arq Bras Oftalmol 2020 Mar-Apr;83(2):157-159

Instituto de Olhos, Faculdade de Ciências Médicas de Minas Gerais, Belo Horizonte, MG, Brazil.

A 37-year-old woman complained of headaches following bilateral visual loss in the past two years. She was obese and had undergone bariatric surgery three months earlier, followed by a considerable weight loss. Neuro-ophthalmic examination revealed a bilateral swollen optic disk. Read More

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http://dx.doi.org/10.5935/0004-2749.20200030DOI Listing

Amsler grid test for detection of advanced glaucoma in Ethiopia.

PLoS One 2020 10;15(3):e0230017. Epub 2020 Mar 10.

Department of Ophthalmology and Visual Sciences, University of Alberta, Edmonton, Canada.

Objective: This study was done to determine the validity of amsler grid test black on white (BOW), as well as white on black (WOB) for identifying central visual field (VF) defects in patients with advanced glaucoma.

Design: Prospective study.

Participants: We prospectively included 100 consecutive eyes of 88 adult patients with advanced glaucoma and 100 eyes of 100 normal individuals. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0230017PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7064174PMC

Real-World Retrospective Consecutive Study of Ab Interno XEN 45 Gel Stent Implant with Mitomycin C in Black and Afro-Latino Patients with Glaucoma: 40% Required Secondary Glaucoma Surgery at 1 Year.

Middle East Afr J Ophthalmol 2019 Oct-Dec;26(4):229-234. Epub 2020 Jan 29.

Department of Ophthalmology, Advance Eyecare of New York, New York, NY, USA.

Purpose: The aim of this study was to determine the postoperative course after the ab interno XEN45 Gel Stent implantation in Black and Afro-Latino, patients with glaucoma.

Methods: This was a single-center, retrospective study. All patients with glaucoma who underwent ab interno XEN implantation were included in the study. Read More

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http://dx.doi.org/10.4103/meajo.MEAJO_126_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7034147PMC

Prevalence and Severity of Diabetic Retinopathy among Diabetic Patients Presenting to a Tertiary Eye Hospital in Nepal.

Middle East Afr J Ophthalmol 2019 Oct-Dec;26(4):210-215. Epub 2020 Jan 29.

Florida Retina Institute, Jacksonville, FL, USA.

Purpose: The purpose of the study is to evaluate the prevalence and severity of diabetic retinopathy (DR) among all diabetic patients presenting to a tertiary eye care center in Nepal over a 3-year period.

Materials And Methods: This was a retrospective review of all clinical records from the initial presentations of diabetic patients at the Tilganga Institute of Ophthalmology (TIO) from 2012 to 2014.

Results: In total, 8855 patients were identified who presented to TIO with a prior diagnosis of diabetic mellitus (DM) during the study period. Read More

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http://dx.doi.org/10.4103/meajo.MEAJO_65_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7034152PMC

The Effect of a Reminder Short Message Service on the Uptake of Glaucoma Screening by First-Degree Relatives of Glaucoma Patients: A Randomized Controlled Trial.

Middle East Afr J Ophthalmol 2019 Oct-Dec;26(4):196-202. Epub 2020 Jan 29.

Department of Ophthalmology, Jos University Teaching Hospital, Jos, Plateau State, Nigeria.

Purpose: The purpose of this study was to determine the role of a reminder short message service (SMS) on the uptake of glaucoma screening by first-degree relatives (FDRs) of patients with primary open-angle glaucoma (POAG) in North-central Nigeria following a telephone invitation for screening.

Materials And Methods: A randomized controlled trial was conducted in the eye clinic of a tertiary hospital in Jos, North-central Nigeria. Two hundred FDRs of patients with POAG were invited through phone for free glaucoma screening and randomly allocated into two groups. Read More

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http://dx.doi.org/10.4103/meajo.MEAJO_98_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7034156PMC

Underweight increases the risk of primary open-angle glaucoma in diabetes patients: A Korean nationwide cohort study.

Medicine (Baltimore) 2020 Mar;99(10):e19285

Department of Ophthalmology.

The impact of underweight on the risk of developing primary open-angle glaucoma (POAG) is not known, although the association between obesity and POAG has been well studied. We evaluated the risk of POAG among underweight patients by studying a nationwide cohort sample in South Korea.We analyzed data from the Korean National Health Insurance Research Database collected between 2009 and 2012 for 17,000,636 patients aged 40 years or older. Read More

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http://dx.doi.org/10.1097/MD.0000000000019285DOI Listing
March 2020
5.723 Impact Factor

Near-infrared transillumination imaging combined with aperture photometry for the quantification of melanin in the iris pigment epithelium.

Authors:
Maciej Czepita

PLoS One 2020 6;15(3):e0230210. Epub 2020 Mar 6.

2nd Department of Ophthalmology, Pomeranian Medical University, Szczecin, Poland.

Near-infrared transillumination is used in the diagnosis and the management of different eye diseases. In particular, it enables the visualization of melanin in the pigment epithelium of the iris. This technique is valuable in such conditions as pigment dispersion syndrome and Adie's tonic pupil. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0230210PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7060071PMC

Estimation of the central 10-degree visual field using en-face images obtained by optical coherence tomography.

PLoS One 2020 5;15(3):e0229867. Epub 2020 Mar 5.

Division of Ophthalmology and Visual Science, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan.

Purpose: To estimate the central 10-degree visual field of glaucoma patients using en-face images obtained by optical coherence tomography (OCT), and to examine its usefulness.

Patients And Methods: Thirty-eight eyes of 38 patients with primary open angle glaucoma were examined. En-face images were obtained by swept-source OCT (SS-OCT). Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0229867PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7058317PMC

Factors associated with depression and anxiety among glaucoma patients in a tertiary hospital South-East Nigeria.

Niger J Clin Pract 2020 Mar;23(3):315-321

Department of Physiology, Faculty of Basic Medical Science, University of Nigeria, Enugu Campus, Nigeria.

Objective: To explore the factors associated with depression and anxiety among glaucoma patients.

Subjects And Methods: This was a cross-sectional study involving adult glaucoma patients, who attended the eye clinic of Enugu State University Teaching Hospital, Parklane, Enugu, from April to September 2018. In total, 182 glaucoma patients with no other significant ophthalmic or medical conditions were recruited. Read More

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http://dx.doi.org/10.4103/njcp.njcp_140_19DOI Listing

Continuous intraocular pressure monitoring in patients with obstructive sleep apnea syndrome using a contact lens sensor.

PLoS One 2020 3;15(3):e0229856. Epub 2020 Mar 3.

Department of Ophthalmology, Clínica Universidad de Navarra, University of Navarra, Pamplona, Navarra, Spain.

Purpose: To analyse nocturnal intraocular pressure (IOP) fluctuations in patients with obstructive sleep apnea syndrome (OSAS) using a contact lens sensor (CLS) and to identify associations between the OSAS parameters determined by polysomnographic study (PSG) and IOP changes.

Method: Prospective, observational study. Twenty participants suspected of having OSAS were recruited. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0229856PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7053760PMC

[The role of family doctor in early detection of glaucoma].

Authors:
K M Salikhova

Probl Sotsialnoi Gig Zdravookhranenniiai Istor Med 2020 Jan;28(1):34-38

The A. Aliev State University of Advanced Education of Physicians, AZ1012 Baku, the Republic of Azerbaijan,

The purpose of the study is to assess medical efficiency of family doctors involved in early detection of glaucoma.

Materials And Methods: The prospective observation was carried on in polyclinic No.3 (the basis institution of the University Department of family medicine) to provide experimental evidence of role of family physician in medical care of ophthalmic patients. Read More

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http://dx.doi.org/10.32687/0869-866X-2020-28-1-34-38DOI Listing
January 2020

Prevalence and risk factors of diabetic retinopathy in diabetic patients: A community based cross-sectional study.

Medicine (Baltimore) 2020 Feb;99(9):e19236

Department of Ophthalmology.

In China, there is a significant lack of awareness of diabetes and its complications. Screening of diabetic retinopathy has important for early detection, prevention, and treatment. This large, cross-sectional study aimed to characterize the demographic, physical, serological, and ocular characteristics of subjects with diabetes mellitus in Shijiazhuang, China. Read More

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http://dx.doi.org/10.1097/MD.0000000000019236DOI Listing
February 2020
5.723 Impact Factor

Neurological manifestations of autoinflammatory diseases in Chinese adult patients.

Semin Arthritis Rheum 2020 Feb 3. Epub 2020 Feb 3.

Department of Rheumatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Beijing, China. Electronic address:

Objective: Systemic autoinflammatory diseases (SAIDs) are a group of disorders characterized by a dysregulation of innate immune system leading to multi-systemic inflammation. We aim to assess the neurological manifestations of Chinese adult patients with SAIDs.

Methods: Eighty adult patients (≥16 years) were diagnosed as SAIDs from April 2015 to June 2019, at the center of adult autoinflammatory diseases, Department of Rheumatology, Peking Union Medical College Hospital. Read More

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http://dx.doi.org/10.1016/j.semarthrit.2019.12.003DOI Listing
February 2020
3.925 Impact Factor

Intra- and inter-hemispheric processing during binocular rivalry in mild glaucoma.

PLoS One 2020 25;15(2):e0229168. Epub 2020 Feb 25.

Krembil Research Institute, Toronto Western Hospital, Toronto, Ontario, Canada.

Glaucoma is considered a progressive optic neuropathy because of the damage and death of the retinal ganglion cells. It is also a neurodegenerative disease because it affects neural structures in the visual system and beyond, including the corpus callosum-the largest white matter structure involved in inter-hemispheric transfer of information. In this study we probed the dysfunction of the inter-hemispheric processing in patients with mild glaucoma using the phenomenon of binocular rivalry. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0229168PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7041812PMC

Virus-associated anterior uveitis and secondary glaucoma: Diagnostics, clinical characteristics, and surgical options.

PLoS One 2020 24;15(2):e0229260. Epub 2020 Feb 24.

Berlin Institute of Health, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany.

In this retrospective, single-center, observational study, we compared the clinical characteristics, analyzed the glaucoma development, and the glaucoma surgery requirement mediators in patients with different virus-associated anterior uveitis (VAU). In total, 270 patients (= eyes) with VAU confirmed by positive Goldmann-Witmer coefficients (GWC) for cytomegalovirus (CMV), herpes simplex virus (HSV), varicella-zoster virus (VZV), rubella virus (RV), and multiple virus (MV) were included. Clinical records of these patients were analyzed. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0229260PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7039515PMC
June 2020
3.234 Impact Factor

Biallelic CPAMD8 Variants Are a Frequent Cause of Childhood and Juvenile Open-Angle Glaucoma.

Ophthalmology 2020 Jun 7;127(6):758-766. Epub 2020 Jan 7.

Department of Ophthalmology, Flinders University, Adelaide, Australia.

Purpose: Developmental abnormalities of the ocular anterior segment in some cases can lead to ocular hypertension and glaucoma. CPAMD8 is a gene of unknown function recently associated with ocular anterior segment dysgenesis, myopia, and ectopia lentis. We sought to assess the contribution of biallelic CPAMD8 variants to childhood and juvenile open-angle glaucoma. Read More

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http://dx.doi.org/10.1016/j.ophtha.2019.12.024DOI Listing

Tilted Optic Disc Frequency in Myopia of Different Degree.

Med Arch 2019 Dec;73(6):391-393

Eye Clinic, Clinical Center University of Sarajevo, Bosnia and Herzegovina.

Introduction: Change in the fundus in myopic patients are often characterized by partially atrophic and tilted optic disc insertions. Due to the altered nerve fiber arrangement, it is more difficult to detect the initial pathological changes of the optic disc. This subject is important because myopia represents well known risk factor for glaucoma. Read More

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http://dx.doi.org/10.5455/medarh.2019.73.391-393DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7007631PMC
December 2019

Association of IL-10 gene promoter polymorphisms with susceptibility to pseudoexfoliation syndrome, pseudoexfoliative and primary open-angle glaucoma.

BMC Med Genet 2020 02 12;21(1):32. Epub 2020 Feb 12.

Mycobacteriology Research Centre (MRC), National Research Institute of Tuberculosis and Lung Disease (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Background: The involvement of cytokines in pathogenesis of pseudoexfoliation syndrome and glaucoma has been demonstrated in several studies. The aim of the present study was to explore the association between three promoter polymorphisms -592C/A (rs1800872), - 819C/T (rs1800871) and -1082A/G (rs1800896) of interleukin 10 (IL-10) gene with susceptibility to pseudoexfoliation syndrome (PEX), pseudoexfoliative glaucoma (PEXG), and primary open-angle glaucoma (POAG).

Methods: In this study, 114 PEX, 118 PEXG, 114 POAG patients and 126 healthy individuals from Iranian population were participated. Read More

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http://dx.doi.org/10.1186/s12881-020-0969-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7017446PMC
February 2020

Visual function evaluation for low vision patients with advanced glaucoma.

Medicine (Baltimore) 2020 Feb;99(7):e19149

Department of Ophthalmology, Seoul St. Mary's Hospital.

This study aimed to compare various visual function parameters for evaluating the quality of life (QOL) of patients with advanced glaucoma with low vision.In total, 44 eyes of advanced glaucoma patients with low vision were included in this cross-sectional study. A moving pattern edge band program was used to assess edge detection ability and the low vision quality-of-life (LVQOL) questionnaire was used for evaluating QOL scores of subjects. Read More

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http://dx.doi.org/10.1097/MD.0000000000019149DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7035097PMC
February 2020

Corneal biomechanical responses detected using corvis st in primary open angle glaucoma and normal tension glaucoma.

Medicine (Baltimore) 2020 Feb;99(7):e19126

Department of Ophthalmology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.

Structural differences have been reported between primary open angle glaucoma (POAG) and normal tension glaucoma (NTG), and biomechanical differences between POAG and NTG may account for why NTG patients are more vulnerable to lower intraocular pressure (IOP). This study compared the biomechanical properties of POAG and NTG patients using the Corvis scheimpflug technology (ST) non-contact Scheimpflug-based tonometer, and determined the factors associated with these properties.In this retrospective cross-sectional study, 46 eyes with POAG, 54 eyes with NTG, and 61 control eyes were included. Read More

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http://dx.doi.org/10.1097/MD.0000000000019126DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7035014PMC
February 2020

Diode laser transscleral cyclophotocoagulation for uveitis-glaucoma-hyphema syndrome: A case report.

Medicine (Baltimore) 2020 Feb;99(7):e18637

Affiliated Eye Hospital of Shandong University of Traditional Chinese Medicine, Jinan 250002, China.

Rationale: To report a case of diode laser transscleral cyclophotocoagulation (DLTSC) for uveitis-glaucoma-hyphema syndrome (UGH).

Patient Concerns: The patient developed UGH on the right eye (OD) after vitrectomy and intraocular lens (IOL) implantation.

Diagnoses: Best corrected visual acuity (BCVA) was HM/50 cm, intraocular pressure (IOP) was 51. Read More

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http://dx.doi.org/10.1097/MD.0000000000018637DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7035089PMC
February 2020

[Neuroprotection and Regeneration in the Central Nervous System].

Klin Monbl Augenheilkd 2020 Feb 10;237(2):128-132. Epub 2020 Feb 10.

Linda van Aelst Lab, Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, United States.

The development of neuroprotective and regenerative therapies in the central nervous system (CNS) poses a major challenge in clinical and basic research. In contrast to the peripheral nervous system, which has a comparatively high intrinsic regenerative capacity, this characteristic is poorly developed in the adult CNS. In this review, some basic growth mechanisms of CNS neurons will be highlighted, as well as factors that prevent successful regeneration after injury. Read More

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http://dx.doi.org/10.1055/a-1079-5905DOI Listing
February 2020

Response of the Trilaminar Retinal Vessel Network to Intraocular Pressure Elevation in Rat Eyes.

Invest Ophthalmol Vis Sci 2020 02;61(2)

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Purpose: The purpose of this study was to test the hypothesis that the superficial, intermediate, and deep retinal vascular plexus show different responses to intraocular pressure (IOP) elevation.

Methods: Anesthetized adult Long Evans rats (n = 14) were imaged using optical coherence tomography angiography (OCTA; Spectralis) at baseline (IOP 10 mm Hg) and in follow-up mode to examine the vasculature during IOP elevation (10 to 110 mm Hg, 10 mm Hg steps, each step 3 minutes). A 20° × 10° field was imaged. Read More

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http://dx.doi.org/10.1167/iovs.61.2.2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7325622PMC
February 2020

One-year outcome of low dose laser cyclophotocoagulation for capsular tension ring-induced malignant glaucoma: A case report.

Medicine (Baltimore) 2020 Feb;99(6):e18836

The Eye Hospital of Wenzhou Medical University, Zhejiang Eye Hospital.

Rationale: Malignant glaucoma is a refractory glaucoma which often relentlessly worsened despite conventional therapy. Ultrasonographic biomicroscopy always cannot show the ciliary-block of malignant glaucoma. We report a case of capsular tension ring induced ciliary-block and successfully treated by low dose laser cyclophotocoagulation, with 1-year follow-up. Read More

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http://dx.doi.org/10.1097/MD.0000000000018836DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7015563PMC
February 2020

Effect of Manual Upper Eyelid Elevation on Intraocular Pressure Measurement by Four Different Tonometers.

Optom Vis Sci 2020 02;97(2):128-133

Department of Ophthalmology and Visual Sciences, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan.

Significance: This study is the first to show that the manual upper eyelid elevation (manual UEE) that is commonly used to prevent disruption of the IOP measurement due to blinking or upper eyelid contact with the tip of the tonometer does not affect the IOP values.

Purpose: We investigated whether manual UEE affects the IOP readings using three rebound tonometers (Icare TA01i, Icare PRO, and Icare ic100) and Goldmann applanation tonometry (GAT).

Methods: One eye was measured for 101 patients (56 eyes of primary open-angle glaucoma patients and 45 healthy subjects). Read More

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http://dx.doi.org/10.1097/OPX.0000000000001472DOI Listing
February 2020

Case Report: Glaucoma-associated Peripapillary Retinoschisis with Corresponding Lamina Cribrosa Defect.

Optom Vis Sci 2020 02;97(2):104-109

Eye Clinic, Providence Veterans Affairs Medical Center, Providence, Rhode Island.

Significance: Peripapillary retinoschisis is associated with primary and secondary glaucoma. It is important that clinicians are familiar with the presentation and management of peripapillary retinoschisis to understand its effects on the patient's glaucoma and to avoid unnecessary referral when the macula is not involved.

Purpose: We present a case of peripapillary retinoschisis found incidentally on routine optical coherence tomographic (OCT) surveillance of primary open-angle glaucoma. Read More

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http://dx.doi.org/10.1097/OPX.0000000000001474DOI Listing
February 2020

Determining Significant Elevation of Intraocular Pressure Using Self-tonometry.

Optom Vis Sci 2020 02;97(2):86-93

Centre for Eye Health and School of Optometry and Vision Science, University of New South Wales, Kensington, New South Wales, Australia.

Significance: Icare HOME rebound tonometry is increasingly adopted into clinical practice for IOP phasing of glaucoma patients and suspects. Because of measurement differences with applanation tonometry and diurnal fluctuations, interpretation of the IOP measured with Icare HOME phasing can be challenging.

Purpose: The purpose of this study was to use a large patient cohort to develop a practical, analytical tool for interpreting Icare HOME measurements with respect to applanation pressure. Read More

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http://dx.doi.org/10.1097/OPX.0000000000001478DOI Listing
February 2020

Assessing Corneal Speckle in Optical Coherence Tomography: A New Look at Glaucomatous Eyes.

Optom Vis Sci 2020 02;97(2):62-67

Department of Ophthalmology, Wrocław Medical University, Wrocław, Poland.

Significance: Optical coherence tomography speckle is used here in an unconventional way as the indirect source of information on tissue microstructure. The study reveals that the corneal speckle of glaucoma suspects has a similar relationship between the parameters of scattering exhibited in glaucoma patients.

Purpose: The purpose of this study was to evaluate the potential of optical coherence tomography imaging of the cornea in early diagnosis of glaucoma. Read More

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http://dx.doi.org/10.1097/OPX.0000000000001476DOI Listing
February 2020

Assessing the Impact of En Face Retinal Nerve Fiber Layer Imaging on Clinical Decision Making for Glaucoma Suspects.

Optom Vis Sci 2020 02;97(2):54-61

Indiana University School of Optometry, Bloomington, Indiana.

Significance: Assessing and managing glaucoma are a complicated process in which experience plays a key role in decision making. Although advanced glaucoma is more easily diagnosed, patients with early glaucoma or who present with suspicious findings are more complicated. A need to aid clinicians in the decision-making process exists. Read More

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http://dx.doi.org/10.1097/OPX.0000000000001479DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7004462PMC
February 2020

Efficacy of Repeat Selective Laser Trabeculoplasty in Medication-Naive Open-Angle Glaucoma and Ocular Hypertension during the LiGHT Trial.

Ophthalmology 2020 04 30;127(4):467-476. Epub 2019 Oct 30.

NIHR Biomedical Research Centre at Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, United Kingdom. Electronic address:

Purpose: To determine the efficacy of repeat selective laser trabeculoplasty (SLT) in medication-naive open-angle glaucoma (OAG) and ocular hypertensive (OHT) patients requiring repeat treatment for early to medium-term failure during the Laser in Glaucoma and Ocular Hypertension (LiGHT) trial.

Design: Post hoc analysis of SLT treatment arm of a multicenter prospective randomized controlled trial.

Participants: Treatment-naive OAG or OHT requiring repeat 360-degree SLT within 18 months. Read More

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http://dx.doi.org/10.1016/j.ophtha.2019.10.023DOI Listing

To treat or not to treat: a clinical series of retinal arterial macroaneurysms: A single-center retrospective study.

Medicine (Baltimore) 2020 Jan;99(5):e19077

Retinal arterial macroaneurysms (RAMs) develop as outpouchings of the arterial wall that is weakened by arteriosclerosis. The traditional treatment of RAMs comprises observation, focal laser photocoagulation, or surgery. Recently, intravitreal injection of anti-vascular endothelial growth factor (VEGF) drugs has been announced as an effective therapy for fovea-threatening RAMs and quickly improve visual acuity and central retinal thickness (CRT). Read More

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http://dx.doi.org/10.1097/MD.0000000000019077DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7004597PMC
January 2020