29,148 results match your criteria Glaucoma Suspect Adult


Ciliochoroidal detachment after Ahmed glaucoma valve implantation: a retrospective study.

BMC Ophthalmol 2019 Feb 6;19(1):46. Epub 2019 Feb 6.

Affiliated Eye Hospital, School of Ophthalmology and Optometry, Wenzhou Medical University, Zhejiang, China.

Background: To investigate the occurrence of ciliochoroidal detachment (CCD), its risk factors and its impact on the success rate after Ahmed glaucoma valve (AGV) implantation.

Methods: This is a retrospective observational study carried out at Eye Hospital of Wenzhou Medical University, Zhejiang, China. Patients with uncontrolled glaucoma who underwent AGV implantation alone or combined with phacoemulsification (AGV-Phaco) in the hospital from April 1, 2013 to July 31, 2016 were included. Read More

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http://dx.doi.org/10.1186/s12886-019-1060-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368733PMC
February 2019
1 Read
1.075 Impact Factor

Effect of Topical Periocular Steroid Use on Intraocular Pressure: A Retrospective Analysis.

Ophthalmic Plast Reconstr Surg 2019 Feb 4. Epub 2019 Feb 4.

Department of Ophthalmology, Edward S. Harkness Eye Institute, Columbia University Medical Center, New York, New York, U.S.A.

Purpose: To study the effect of periocular steroid use on intraocular pressure (IOP).

Methods: Charts of adult patients with atopic dermatitis or eczema treated with topical periocular steroid creams and ointments from January 1st, 2007 to October 1st, 2017 were reviewed. Patients with the following were excluded: glaucoma, ocular hypertension, known systemic/topical/injectable steroid history, and lack of documented IOP prior to or during treatment with periocular steroid ointment. Read More

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http://dx.doi.org/10.1097/IOP.0000000000001320DOI Listing
February 2019
1 Read

Combined phacoemulsification and viscocanalostomy with Ologen implant versus combined phacoemulsification and viscocanalostomy.

BMC Ophthalmol 2019 Feb 6;19(1):45. Epub 2019 Feb 6.

Ophthalmology Department, Zagazig University, Zagazig, 44511, Egypt.

Background: To study the efficacy of the biodegradable collagen implant Ologen® as an adjuvant in phaco-viscocanalostomy in patients with coexisting cataract and primary open angle glaucoma.

Methods: This prospective, interventional, randomized clinical study was done at Alpha Vision Center, Zagazig, Egypt. Patients with coexisting cataract and glaucoma were randomized to receive either phaco-viscocanalostomy (Phacovisco group) (39 eyes) or phaco-viscocanalostomy with Ologen® implant (OloPhacovisco group) (40 eyes). Read More

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http://dx.doi.org/10.1186/s12886-019-1049-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364460PMC
February 2019
1 Read
1.075 Impact Factor

Posterior pole asymmetry analysis and retinal nerve fibre layer thickness measurements in primary angle-closure suspect patients.

BMC Ophthalmol 2019 Jan 28;19(1):36. Epub 2019 Jan 28.

Department of Ophthalmology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, 325027, Zhejiang, China.

Purpose: To measure peripapillary retinal nerve fiber layer (RNFL) thickness and posterior pole retinal thickness in primary angle-closure suspects (PACS) by Spectral domain optical coherence tomography (SD-OCT) and to be compared with normal subjects.

Methods: Thirty five primary angle-closure suspect patients and thirty normal subjects were enrolled in this study. Peripapillary RNFL and posterior pole retinal thickness by posterior pole asymmetry analysis (PPAA) in SD-OCT were measured. Read More

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http://dx.doi.org/10.1186/s12886-019-1034-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350334PMC
January 2019
2 Reads

Changes in glaucoma medication numbers after cataract and glaucoma surgery: A nationwide population-based study.

Medicine (Baltimore) 2019 Jan;98(4):e14128

Graduate Institute of Biomedical Sciences and School of Medicine, College of Medicine.

To determine whether cataract or glaucoma and combined cataract and glaucoma surgery (CGS) affect glaucoma medication usage.We recruited patients who received new diagnoses of glaucoma, either primary open-angle glaucoma (POAG) (International Classification of Diseases, Ninth Revision, Clinical Modification [ICD-9-CM] code 365.1) or primary angle-closure glaucoma (PACG) (ICD-9-CM code 365. Read More

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http://dx.doi.org/10.1097/MD.0000000000014128DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358407PMC
January 2019
2 Reads

Bone wax migrates to the orbit in a patient with a frontal sinus abnormality: a case report.

BMC Ophthalmol 2019 Jan 24;19(1):29. Epub 2019 Jan 24.

Department of Ophthalmology, the 2nd Xiangya Hospital, Central South University, Changsha, 410011, Hunan Province, China.

Background: Bone wax is the most widely used hemostatic bone sealant because of its availability, ease of use, immediate action, and minimal adverse effects. Several complications have been reported to be associated with the use of bone wax, such as infection, osteohypertrophy, pain, granuloma formation, allergic reaction, and thrombosis. Here, we present a rare complication, namely, bone wax migration, which developed after a craniotomy on a patient who had a frontal sinus abnormality. Read More

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http://dx.doi.org/10.1186/s12886-019-1037-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6345031PMC
January 2019
2 Reads

Changes in choroidal thickness and optic nerve head morphology after filtering surgery: nonpenetrating deep sclerectomy versus trabeculectomy.

BMC Ophthalmol 2019 Jan 21;19(1):24. Epub 2019 Jan 21.

Department of Ophthalmology III, Quinze-Vingts National Ophthalmology Hospital, DHU Sight Restore, 28 rue de Charenton, 75012, Paris, France.

Background: The purpose of this study was to evaluate the changes in choroidal thickness and lamina cribrosa position after nonpenetrating deep sclerectomy (NPDS) and trabeculectomy.

Methods: Twenty-three eyes with glaucoma that required filtering surgery were included (12 NDPS and 11 trabeculectomies) in this prospective observational study. OCT-enhanced depth imaging (OCT-EDI) was used to measure choroidal thickness, prelaminar tissue thickness and lamina cribrosa position before and 7 days and 1 month after surgery. Read More

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http://dx.doi.org/10.1186/s12886-019-1031-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341643PMC
January 2019
3 Reads

The cost-effectiveness of medication, laser trabeculoplasty, and trabeculectomy for treatment of open-angle glaucoma in South Korea.

Medicine (Baltimore) 2019 Jan;98(2):e14026

Department of Ophthalmology and Visual Science, St Vincent's Hospital College of Medicine, Catholic University of Korea, Seoul, South Korea.

Objectives: Open-angle glaucoma (OAG) imposes high disease burden in South Korea. Although various effective interventions are available to manage the progression of OAG, there is limited data on the cost-effectiveness of these treatment strategies in South Korea.

Methods: Using a Markov cohort model, we evaluated the cost-effectiveness of 3 major treatment strategies (medication, laser trabeculoplasty, and trabeculectomy) for South Korean patients with OAG. Read More

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http://dx.doi.org/10.1097/MD.0000000000014026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6336655PMC
January 2019
11 Reads

A novel application of B-ultrasonography at various head positions in the diagnosis of untypical uveitis-glaucoma-hyphema (UGH) syndrome: A case report.

Medicine (Baltimore) 2019 Jan;98(2):e13891

Department of Ophthalmology, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.

Rationale: Uveitis-glaucoma-hyphema (UGH) syndrome could be identified by conventional ultrasound biomicroscopy (UBM) and B-ultrasonography, but failed in some untypical cases. We introduced a novel application of B-ultrasonography in diagnosis of UGH syndrome in a rare case.

Patient Concerns: A 60-year-old woman was referred for distending pain with blurred vision for more than 1 month in the right eye after cataract surgery. Read More

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http://dx.doi.org/10.1097/MD.0000000000013891DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6336659PMC
January 2019
8 Reads

Long-term results of glaucoma drainage device surgery.

BMC Ophthalmol 2019 Jan 10;19(1):14. Epub 2019 Jan 10.

Department of Ophthalmology, University Medical Center Schleswig-Holstein, Arnold-Heller Strasse 3, Haus 25, D-24105, Kiel, Germany.

Background: To evaluate long-term results of eyes with glaucoma drainage device (GDD).

Methods: We retrospectively reviewed medical records of all patients who underwent GDD placement at our institution between 2001 and 2014. A total of 110 eyes of 90 patients were studied. Read More

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https://bmcophthalmol.biomedcentral.com/articles/10.1186/s12
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http://dx.doi.org/10.1186/s12886-019-1027-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327392PMC
January 2019
6 Reads

Diagnostic ability of macular ganglion cell asymmetry in Preperimetric Glaucoma.

BMC Ophthalmol 2019 Jan 8;19(1):12. Epub 2019 Jan 8.

Department of Ophthalmology, Taipei Veterans General Hospital, 201, Section 2, Shih-Pai Road, Taipei, 11217, Taiwan.

Background: To evaluate the diagnostic ability of macular ganglion cell asymmetry to diagnose preperimetric glaucoma (PPG), using Cirrus spectral domain optical coherence tomography (OCT).

Methods: This prospective study included 67 eyes of 67 patients with PPG and 67 eyes of 67 age- and refractive error-matched controls. We measured circumpapillary RNFL (cpRNFL) thickness, macular ganglion cell-inner plexiform layer (GCIPL) thickness and optic nerve head (ONH) parameters using OCT. Read More

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https://bmcophthalmol.biomedcentral.com/articles/10.1186/s12
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http://dx.doi.org/10.1186/s12886-018-1019-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6325869PMC
January 2019
7 Reads

Corneal Endothelial Cell Density and Morphology After Phacoemulsification in Patients With Primary Open-Angle Glaucoma and Cataracts: 2-Year Results of a Randomized Multicenter Trial.

Cornea 2019 Mar;38(3):325-331

University of California San Francisco, San Francisco, CA.

Purpose: To evaluate corneal endothelial cell density (ECD) and morphology 2 years after phacoemulsification in subjects from the COMPASS trial (ClinicalTrials.gov, NCT01085357) who had mild-to-moderate primary open-angle glaucoma and visually significant cataracts.

Methods: The central corneal endothelium was evaluated by serial specular microscopy at 0 to 24 months. Read More

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http://dx.doi.org/10.1097/ICO.0000000000001826DOI Listing
March 2019
11 Reads

Peripapillary capillary vessel density progression in advanced glaucoma: a case report.

Authors:
Gábor Holló

BMC Ophthalmol 2019 Jan 5;19(1). Epub 2019 Jan 5.

Department of Ophthalmology, Semmelweis University, Mária u. 39, Budapest, 1085, Hungary.

Background: We report a case of advanced juvenile open-angle glaucoma (JOAG) in which peripapillary capillary vessel density (PcVD) in the inferior retina showed significant progression while the spatially corresponding retinal nerve fiber layer thickness (RNFLT) and visual field cluster defect values had reached their minimal detectable values, and showed no change during the follow-up (floor effect).

Case Presentation: A 45-year old white female patient with very advanced under treatment JOAG in the left eye was prospectively investigated with the AngioVue OCT (Optovue Inc., Fremont, USA) for RNFLT and PcVD, and Octopus Normal G2 visual field testing, at 6-month intervals for 2. Read More

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http://dx.doi.org/10.1186/s12886-018-1021-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6321677PMC
January 2019
3 Reads

The association between prelaminar tissue thickness and peripapillary choroidal thickness in untreated normal-tension glaucoma patients.

Medicine (Baltimore) 2019 Jan;98(1):e14044

Department of Ophthalmology, Korea University College of Medicine, Seoul.

To evaluate the association between prelaminar tissue thickness (PLT) and peripapillary choroidal thickness (PCT) in untreated normal-tension glaucoma (NTG) patients.A cross-sectional study was conducted in 65 untreated NTG patients. All of the subjects were imaged with swept-source optical coherence tomography (SS-OCT, DRI OCT; Topcon, Tokyo, Japan) to obtain the horizontal scan crossing the optic nerve head center. Read More

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http://dx.doi.org/10.1097/MD.0000000000014044DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6344131PMC
January 2019
2 Reads
5.723 Impact Factor

Ab interno gel implant in patients with primary open angle glaucoma and pseudoexfoliation glaucoma.

BMC Ophthalmol 2018 Dec 27;18(1):339. Epub 2018 Dec 27.

Department of Ophthalmology, Ruprecht-Karls-University Heidelberg, 69120, Heidelberg, Germany.

Purpose: To compare efficacy and safety results of an ab interno gel implant in patients with pseudoexfoliation glaucoma (PXG) and primary open angle glaucoma (POAG).

Methods: Retrospective analysis of the medical records of 110 consecutive eyes with open angle glaucoma who had received a XEN45 gel implant between March 2014 and June 2015. Intraocular pressure course, number of glaucoma medications, the need for additional intervention (including needling) and complications were evaluated until 12 months postoperatively. Read More

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https://bmcophthalmol.biomedcentral.com/articles/10.1186/s12
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http://dx.doi.org/10.1186/s12886-018-0989-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307207PMC
December 2018
7 Reads

Juvenile open-angle Glaucoma associated with Leber's hereditary optic neuropathy: a case report and literature review.

BMC Ophthalmol 2018 Dec 17;18(1):323. Epub 2018 Dec 17.

Department of Ophthalmology, Chang-Gung Memorial Hospital, 222 Mai-Chin Rd, Keelung, 204, Taiwan (Republic of China).

Background: Leber's hereditary optic neuropathy (LHON) is a maternally inherited recessive disease rarely complicated with glaucoma. We conducted a clinical and genetic retrospective case series to describe three cases of juvenile open-angle glaucoma (JOAG) and an ND4 m11778G > A mitochondrial DNA (mtDNA) mutation, which is pathognomonic for LHON.

Case Presentation: Patient 1 was a 16-year-old boy diagnosed with bilateral JOAG and high myopia. Read More

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http://dx.doi.org/10.1186/s12886-018-0980-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6296145PMC
December 2018
1 Read

Management of Postoperative Ocular Hypotony after Tube Surgery by Stenting Using Two 5-0 Nylon Threads.

Korean J Ophthalmol 2018 Dec;32(6):523-524

Department of Ophthalmology, Kim's Eye Hospital, Myung-Gok Eye Research Institute, Konyang University College of Medicine, Seoul, Korea.

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http://dx.doi.org/10.3341/kjo.2018.0092DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6288013PMC
December 2018
1 Read

Relationship between Progressive Changes in Lamina Cribrosa Depth and Deterioration of Visual Field Loss in Glaucomatous Eyes.

Korean J Ophthalmol 2018 Dec;32(6):470-477

Department of Ophthalmology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

Purpose: To investigate the relationship between the progression of visual field (VF) loss and changes in lamina cribrosa depth (LCD) as determined by spectral-domain optical coherence tomography (SD-OCT) enhanced depth imaging in patients with primary open angle glaucoma (POAG).

Methods: Data from 60 POAG patients (mean follow-up, 3.5 ± 0. Read More

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http://dx.doi.org/10.3341/kjo.2018.0015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6288017PMC
December 2018

Activation of 5-HT1A receptors promotes retinal ganglion cell function by inhibiting the cAMP-PKA pathway to modulate presynaptic GABA release in chronic glaucoma.

J Neurosci 2018 Dec 12. Epub 2018 Dec 12.

Eye Institute, Eye & ENT Hospital, State Key Laboratory of Medical Neurobiology, Institutes of Brain Science and Collaborative Innovation Center for Brain Science, Shanghai Medical College, Fudan University, Shanghai 200032, China.

Serotonin receptor agonists are neuroprotective in central nervous system (CNS) injury models. However, the neuroprotective functional implications and synaptic mechanism of 8-OH-DPAT, a serotonin receptor (5-HT1A) agonist, in an adult male Wistar rat model of chronic glaucoma model remain unknown. We found that ocular hypertension decreased 5-HT1A receptor expression in rat retinas, as the number of retinal ganglion cells (RGCs) was significantly reduced in rats with induced ocular hypertension relative to that in control retinas, and 8-OH-DPAT enhanced the RGC viability. Read More

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http://dx.doi.org/10.1523/JNEUROSCI.1685-18.2018DOI Listing
December 2018
2 Reads

New perspectives in the use of laser diode transscleral cyclophotocoagulation. A prospective single center observational cohort study.

Rom J Morphol Embryol 2018 ;59(3):869-872

Department of Neurology, "Victor Babeş" University of Medicine and Pharmacy, "Pius Brînzeu" Emergency County Clinical Hospital, Timişoara, Romania; Department of Ophthalmology, "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania;

Purpose: The paper intends to present the results of using new methods of a new generation diode laser transscleral cyclophotocoagulation (TSCPC) in patients with different types of glaucoma.

Patients, Materials And Methods: There have been treated 53 eyes from 59 patients with glaucoma refractory to medical, laser or surgical treatment. We have used the newest generation of 810 nm wavelength diode laser. Read More

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January 2019
1 Read

Diagnostic and prognostic value of the optic nerve sheath diameter with respect to the intracranial pressure and neurological outcome of patients following hemicraniectomy.

BMC Neurol 2018 Dec 5;18(1):199. Epub 2018 Dec 5.

Department of Emergency Medicine, Second Affiliated Hospital, Zhejiang University School of Medicine, No. 88, Jiefang Road, Hangzhou City, 310009, Zhejiang Province, China.

Background: In cases showing cerebrospinal fluid (CSF) redistribution as a compensatory mechanism in acute intracranial hypertension, the optic nerve sheath diameter (ONSD) can be used to estimate intracranial pressure (ICP). However, it remains unclear whether the ONSD can be applied in patients with skull defects after a craniectomy, because the primary injury or surgical craniectomy may alter the dynamics of the CSF circulation or structure of the optical nerve sheath. This study explored the value of the ONSD in patients after a hemicraniectomy. Read More

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http://dx.doi.org/10.1186/s12883-018-1202-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6280512PMC
December 2018
3 Reads

Impact of ab-interno trabeculectomy on Bruch's membrane opening-based morphometry of the optic nerve head for glaucoma progression analysis.

Graefes Arch Clin Exp Ophthalmol 2019 Feb 28;257(2):339-347. Epub 2018 Nov 28.

Department of Ophthalmology, University Hospital of Cologne, Kerpener Strasse 62, 50924, Cologne, Germany.

Purpose: To analyze the longitudinal change in Bruch's membrane opening minimal rim width (BMO-MRW) and circumpapillary retinal nerve fiber layer (RNFL) thickness using spectral domain optical coherence tomography (SD-OCT) after glaucoma surgery via ab-interno trabeculectomy in adult glaucoma patients.

Methods: Retrospective audit of 65 eyes of 65 participants undergoing ab-interno trabeculectomy using electroablation of the trabecular meshwork. In 53 eyes, surgery was combined with phacoemulsification and posterior chamber lens implantation. Read More

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http://dx.doi.org/10.1007/s00417-018-4187-2DOI Listing
February 2019
1 Read

Diffusion Tensor Imaging Detects Microstructural Differences of Visual Pathway in Patients With Primary Open-Angle Glaucoma and Ocular Hypertension.

Front Hum Neurosci 2018 22;12:426. Epub 2018 Oct 22.

Department of Ophthalmology, Huashan Hospital, Fudan University, Shanghai, China.

Ocular hypertension (OHT), the common situation in adult patients in the outpatients, occurs ∼5% worldwide. However, there are still some practical problems in differentiation of OHT with early primary open-angle glaucoma (POAG) using current standard methods. Application of high resolution diffusion tensor imaging (DTI) enables us to the differentiate axonal architecture of visual pathway between POAG and OHT subjects. Read More

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http://dx.doi.org/10.3389/fnhum.2018.00426DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6232882PMC
October 2018
15 Reads

Outcomes of rhegmatogenous retinal detachment surgery in eyes with pre-existing glaucoma drainage devices.

Indian J Ophthalmol 2018 Dec;66(12):1820-1824

Shri Bhagwan Mahavir Vitreoretinal Services, Medical Research Foundation, Sankara Nethralaya, Chennai, Tamil Nadu, India.

Purpose: To evaluate the outcome of rhegmatogenous retinal detachment (RRD) surgery in eyes with preplaced glaucoma drainage device (GDD) with respect to intraocular pressure (IOP) control as well as success of retinal detachment (RD) surgery.

Methods: It is a retrospective case series. The case records of patients who underwent RD surgery after GDD implantation from 2000 to 2014 were screened. Read More

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http://dx.doi.org/10.4103/ijo.IJO_438_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6256886PMC
December 2018
1 Read

[Clinical features of glucocorticoid eye drops induced ocular hypertension in pediatric and adult uveitic eyes].

Zhonghua Yan Ke Za Zhi 2018 Nov;54(11):839-842

Department of Ophthalmology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China.

To investigate the clinical features of glucocorticoid eye drops induced ocular hypertension in pediatric and adult uveitic eyes. Retrospective survey of consecutive uveitic patients attending referral service at Peking Union Medical College Hospital from March 2013 to August 2017. Incidences of glucocorticoid eye drops induced ocular hypertension were compared between the pediatric and adult uveitic groups. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0412-4081.2018.11.008DOI Listing
November 2018
10 Reads

TGF-β-induced IOP elevations are mediated by RhoA in the early but not the late fibrotic phase of open angle glaucoma.

Mol Vis 2018 29;24:712-726. Epub 2018 Oct 29.

Neuroscience and Ophthalmology Research Group, Institute of Inflammation and Ageing, University of Birmingham, Birmingham, United Kingdom.

Purpose: Elevations in intraocular pressure (IOP) are associated with the development of glaucoma and loss of sight. High transforming growth factor-β (TGF-β) 1 levels in the eye's anterior chamber can lead to dysfunctional contractions through RhoA signaling in trabecular meshwork (TM) cells and IOP spikes. Sustained high TGF-β levels leads to TM fibrosis and sustained increases in IOP. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6205807PMC
January 2019
8 Reads

Time Course Changes of the Mechanical Properties of the Iris Pigment Epithelium in a Rat Chronic Ocular Hypertension Model.

Biomed Res Int 2018 21;2018:4862309. Epub 2018 Oct 21.

School of Biomedical Engineering, Capital Medical University, Beijing 100069, China.

Background: The flow field of aqueous humor correlates to the stiffness of iris pigment epithelium (IPE) which acts as a wall of posterior chamber. We focus on the variations of IPE stiffness in a rat ocular hypertension (OHT) model, so as to prepare for exploring the mechanism of duration of OHT.

Methods: Episcleral venous cauterization (EVC) was applied on one eye of male adult Sprague-Dawley rats to induce chronic high intraocular pressure. Read More

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http://dx.doi.org/10.1155/2018/4862309DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6215589PMC
October 2018
1 Read

Anatomical Characterization of an Optic Disc Notch Using SD-OCT in Glaucoma.

Semin Ophthalmol 2018 5;33(7-8):878-885. Epub 2018 Nov 5.

a Glaucoma service , LV Prasad Eye Institute , Bhubaneswar , India.

Purpose: To characterize anatomical dimensions of a disc notch using novel methods using spectral domain optical coherence tomography (SD-OCT).

Participants: All age- and severity-matched glaucoma patients with disc notch (defined as complete loss of neural rim with no residual rim between disc and cup) seen from 2014 to 2015 who underwent enhanced depth imaging with SD-OCT (Cirrus HD-OCT version 6.5, Carl Zeiss, USA) were included for this retrospective observational study. Read More

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https://www.tandfonline.com/doi/full/10.1080/08820538.2018.1
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http://dx.doi.org/10.1080/08820538.2018.1540709DOI Listing
November 2018
9 Reads

Cyanoacrylate glue in an inadvertent trabeculectomy flap tear.

Authors:
Niro Kasahara

Graefes Arch Clin Exp Ophthalmol 2019 Feb 3;257(2):439-440. Epub 2018 Nov 3.

, Sao Paulo, SP, Brazil.

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http://dx.doi.org/10.1007/s00417-018-4177-4DOI Listing
February 2019

Anterior segment Scheimpflug imaging for detecting primary angle closure disease.

Graefes Arch Clin Exp Ophthalmol 2019 Jan 30;257(1):161-167. Epub 2018 Oct 30.

Department of Ophthalmology, Graduate School of Medicine, Osaka University, 2-2 Yamada-Oka, Suita, Osaka, 565-0871, Japan.

Purpose: To evaluate the capability of anterior segment Scheimpflug imaging for detecting primary angle closure disease (PACD): primary angle closure suspect, primary angle closure, and primary angle closure glaucoma, using cutoff points derived from reference databases of healthy subjects.

Methods: Eighty-seven patients with PACD and 49 age-matched control subjects were included. We evaluated the sensitivity and specificity of anterior chamber depth (ACD), anterior chamber volume (ACV), and anterior chamber angle (ACA) to differentiate patients with PACD from controls. Read More

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http://link.springer.com/10.1007/s00417-018-4171-x
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http://dx.doi.org/10.1007/s00417-018-4171-xDOI Listing
January 2019
1 Read

Central corneal thickness in a Jordanian population and its association with different types of Glaucoma: cross-sectional study.

BMC Ophthalmol 2018 Oct 29;18(1):279. Epub 2018 Oct 29.

Department of Ophthalmology, University of Jordan Hospital, The University of Jordan, Amman, 11942, Jordan.

Background: Central corneal thickness (CCT) has long been implicated to affect glaucoma predisposition. Several reports have identified that thinner CCT is a risk factor for open-angle glaucoma, and that CCT can be very variable between different ethnic groups. In this study, we aim to identify the relation between CCT and different glaucoma parameters in different types of glaucoma in an Arabian ethnicity. Read More

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https://bmcophthalmol.biomedcentral.com/articles/10.1186/s12
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http://dx.doi.org/10.1186/s12886-018-0944-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6206916PMC
October 2018
3 Reads

Ocular Surface Stem Cell Transplantation for Treatment of Keratitis-Ichthyosis-Deafness Syndrome.

Cornea 2019 Jan;38(1):123-126

Department of Ophthalmology, Cincinnati Eye Institute, University of Cincinnati, Cincinnati, OH.

Purpose: To report our surgical experience with ocular surface stem cell transplantation (OSST) for limbal stem cell deficiency (LSCD) in the setting of keratitis-ichthyosis-deafness (KID) syndrome.

Methods: Retrospective interventional case series.

Results: We present 5 eyes of 3 patients with KID syndrome that developed LSCD and underwent OSST. Read More

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http://dx.doi.org/10.1097/ICO.0000000000001802DOI Listing
January 2019
22 Reads

Additive intraocular pressure-lowering effects of the Rho kinase inhibitor ripasudil in Japanese patients with various subtypes of glaucoma.

Jpn J Ophthalmol 2019 Jan 28;63(1):40-45. Epub 2018 Oct 28.

Department of Ophthalmology, Faculty of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo, Tokyo, 113-8655, Japan.

Purpose: The present study aimed to investigate the effectiveness of adjunctive therapy involving the Rho-associated, coiled-coil-containing protein kinase (ROCK) inhibitor ripasudil in lowering intraocular pressure (IOP) in patients with different subtypes of glaucoma, on the basis of the time of IOP measurement STUDY DESIGN: Retrospective study METHODS: In total, 58 patients who underwent adjunctive therapy with ripasudil at a single institution were included. They were classified into a primary open-angle glaucoma (POAG) group, an exfoliation glaucoma (XFG) group, and a secondary glaucoma associated with uveitis, or steroid glaucoma (SG), group. The average IOPs within 6 months before (pre-IOP) and after (post-IOP) the addition of ripasudil were compared among the 3 groups. Read More

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http://link.springer.com/10.1007/s10384-018-0635-0
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http://dx.doi.org/10.1007/s10384-018-0635-0DOI Listing
January 2019
22 Reads

Spatial correlation between localized decreases in exploratory visual search performance and areas of glaucomatous visual field loss.

Graefes Arch Clin Exp Ophthalmol 2019 Jan 27;257(1):153-160. Epub 2018 Oct 27.

Department of Ophthalmology, Otorhinolaryngology and Head and Neck Surgery, Ribeirão Preto Medical School- University of São Paulo, Av. Bandeirantes, 3900 - 12°. Andar. Ribeirão Preto, São Paulo, Brazil.

Background: Visual search is a critical skill for several daily tasks and may be compromised in patients with impaired vision. The objective of this study was to study the relationships between exploratory visual search performance (EVSP) visual field (VF) sensitivity in patients with glaucoma.

Methods: Primary open-angle glaucoma patients (POAG; n = 29) and healthy (Control; n = 28) individuals with best corrected visual acuity better than 0. Read More

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http://link.springer.com/10.1007/s00417-018-4164-9
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http://dx.doi.org/10.1007/s00417-018-4164-9DOI Listing
January 2019
7 Reads

A prospective randomized controlled study of Aurolab aqueous drainage implant versus Ahmed glaucoma valve in refractory glaucoma: A pilot study.

Indian J Ophthalmol 2018 Nov;66(11):1580-1585

Advanced Eye Center, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Purpose: To study the efficacy of the Aurolab aqueous drainage implant (AADI) compared to Ahmed glaucoma valve (AGV) in patients with refractory glaucoma.

Methods: This was a prospective, randomized controlled trial. Thirty-eight adult patients (>18 years) scheduled for a glaucoma drainage device (GDD) were randomized into two groups to receive either AGV or AADI. Read More

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http://www.ijo.in/text.asp?2018/66/11/1580/244058
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http://dx.doi.org/10.4103/ijo.IJO_427_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6213703PMC
November 2018
14 Reads
0.930 Impact Factor

[Late and sustained intraocular pressure elevation related to intravitreal anti-VEGF injections: Cases requiring filtering surgery (French translation of the article)].

J Fr Ophtalmol 2018 Nov 19;41(9):789-801. Epub 2018 Oct 19.

Centre hospitalier national d'ophtalmologie des 15-20, 28, rue de Charenton, 75012 Paris, France.

We report cases of delayed, sustained elevated intraocular pressure (IOP) associated with repeated intravitreal anti-VEGF injections (IVI), which ultimately resulted in the need for filtering surgery. Two of the three cases demonstrated severe IOP elevation despite maximal medical treatment following unilateral IVI and required urgent filtering surgery. Optic nerve involvement was severe in all three cases. Read More

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http://dx.doi.org/10.1016/j.jfo.2018.03.014DOI Listing
November 2018

[Optic disc features on OCT in glaucomatous and normal black Africans].

J Fr Ophtalmol 2018 Nov 19;41(9):847-851. Epub 2018 Oct 19.

Département d'ophtalmologie, Université de Lomé, Lomé, Togo.

Purpose: To determine the correlations between the size of the optic disc and glaucomatous defects in black Africans.

Design: Retrospective observational study.

Methods: The study was conducted over a two-year period from November 2014 to October 2016, based on records of black Togolese patients who had undergone optic nerve head (ONH) OCT or ganglion cell complex OCT for assessment of glaucoma. Read More

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http://dx.doi.org/10.1016/j.jfo.2018.02.014DOI Listing
November 2018
9 Reads

Association of Genes implicated in primary angle-closure Glaucoma and the ocular biometric parameters of anterior chamber depth and axial length in a northern Chinese population.

BMC Ophthalmol 2018 Oct 22;18(1):271. Epub 2018 Oct 22.

People's Hospital of Ningxia Hui Autonomous Region, Ningxia Eye Hospital (First Affiliated Hospital of Northwest University For Nationalities), 936 Huang He East Road, Yinchuan, 750011, China.

Background: The membrane frizzled-related protein (MFRP) gene is involved in axial length (AL) regulation and MFRP mutations cause nanophthalmos; also, the hepatocyte growth factor (HGF) gene is reported to result in morphologic changes of the anterior segment and abnormal aqueous regulation that increases the risk of primary angle-closure glaucoma (PACG), while the zinc ring finger 3 (ZNRF3) gene is associated with AL. The present study investigated the association of single nucleotide polymorphisms (SNPs) in ZNRF3, HGF and MFRP with PACG in a northern Chinese population, as well as the association of these SNPs with the ocular biometric parameters of anterior chamber depth (ACD) and AL.

Methods: A total of 500 PACG patients and 720 controls were recruited. Read More

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https://bmcophthalmol.biomedcentral.com/articles/10.1186/s12
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http://dx.doi.org/10.1186/s12886-018-0934-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6198425PMC
October 2018
10 Reads

Baerveldt-XEN persistent proximal occlusion: solving new problems with old answers.

BMJ Case Rep 2018 Oct 21;2018. Epub 2018 Oct 21.

Department of Ophthalmology, Hospital de Santa Maria, Lisboa, Portugal.

A 51-year-old woman was referred with uncontrolled intraocular pressure (IOP) despite maximal medical IOP-lowering therapy. Her background included several failed glaucoma filtering surgeries, including aqueous drainage devices. Considering the need to perform surgery in a patient with both scarred conjunctiva and corneal endothelial deficiency, a surgical technique combining cornea-friendly XEN stent connected to a large-plate Baerveldt glaucoma implant was undertaken. Read More

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http://casereports.bmj.com/lookup/doi/10.1136/bcr-2018-22695
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http://dx.doi.org/10.1136/bcr-2018-226958DOI Listing
October 2018
13 Reads

Intraoperative Descemet's membrane detachment in a case of phacomorphic glaucoma.

BMJ Case Rep 2018 Oct 21;2018. Epub 2018 Oct 21.

Department of Ophthalmology, Dr. Rajendra Prasad Centre for Ophthalmic Sciences, AIIMS, New Delhi, India.

A 60-year-old female patient with phacomorphic glaucoma underwent initial medical management to control the intraocular pressure (IOP). After 48 hours, a stable IOP was achieved and subsequently the patient was planned for phacoemulsification followed by intraocular lens implantation. There was initial difficulty while reconstructing the corneal wounds; however, phacoemulsification and IOL implantation were uneventful but during viscoelastic removal, an inadvertent Descemet's membrane detachment involving the central cornea was noted. Read More

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http://dx.doi.org/10.1136/bcr-2018-225593DOI Listing
October 2018
4 Reads

Glaucoma severity and intraocular pressure reduction after cataract surgery in eyes with medically controlled glaucoma.

Medicine (Baltimore) 2018 Oct;97(42):e12881

Department of Ophthalmology, University of California, San Francisco, CA.

To investigate the relationship between glaucoma severity and intraocular pressure (IOP) reduction after cataract surgery in patients with medically controlled primary open-angle glaucoma (POAG).Retrospective case series.This study included glaucoma suspects (GS) and POAG patients who underwent cataract surgery and continued to use the same glaucoma medications during the postoperative period of 4 months. Read More

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http://dx.doi.org/10.1097/MD.0000000000012881DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6212290PMC
October 2018
8 Reads

Applications of Isolated-Check Visual Evoked Potential in Early Stage of Open-Angle Glaucoma Patients.

Chin Med J (Engl) 2018 Oct;131(20):2439-2446

Department of Ophthalmology; Beijing Key Laboratory of Restoration of Damaged Ocular Nerve, Peking University Third Hospital, Beijing 100191, China.

Background: Standard automated perimetry does not sufficiently detect early open-angle glaucoma (OAG) in the clinic. New visual function tests for early glaucoma damage are therefore needed. The present study evaluated whether an isolated-check visual evoked potential (icVEP) could be used to detect visual function abnormalities in early-stage OAG and to explore potential related factors. Read More

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http://dx.doi.org/10.4103/0366-6999.243564DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6202595PMC
October 2018

Plexin domain containing 2 (PLXDC2) gene polymorphism rs7081455 may not influence POAG risk in a Saudi cohort.

BMC Res Notes 2018 Oct 16;11(1):733. Epub 2018 Oct 16.

Glaucoma Research Chair, Department of Ophthalmology, College of Medicine, King Saud University, P.O. Box 245, Riyadh, 11411, Saudi Arabia.

Objective: Plexin domain containing 2 (PLXDC2), a cell surface transmembrane protein receptor for pigment epithelium derived factor, is expressed in many tissues including the eye. Polymorphism rs7081455 flanking PLXDC2 has been associated with primary open angle glaucoma (POAG) and its clinical phenotypes and may have a role in POAG. Rs7081455 was genotyped in POAG cases (n = 188) and non-glaucomatous controls (n = 164) of Saudi origin using Taq-Man to determine any association of this variant with POAG and its endophenotypes. Read More

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https://bmcresnotes.biomedcentral.com/articles/10.1186/s1310
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http://dx.doi.org/10.1186/s13104-018-3848-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6192173PMC
October 2018
11 Reads

Etidronate protects chronic ocular hypertension induced retinal oxidative stress and promotes retinal ganglion cells growth through IGF-1 signaling pathway.

Eur J Pharmacol 2018 Dec 13;841:75-81. Epub 2018 Oct 13.

Department of Pharmacy, Quanzhou First Hospital, Quanzhou 362000, Fujian Province, China.

Glaucoma is a common heterogeneous eye disorder that may lead to irreversible blindness. In the present study, we examined whether etidronate, a member of bisphosphonates, may have neuroprotective effects in in vivo and in vitro rat model of glaucoma. In an in vivo setting, chronic ocular hypertension (COH) was induced in adult rat retina. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00142999183057
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http://dx.doi.org/10.1016/j.ejphar.2018.10.002DOI Listing
December 2018
9 Reads

Genome-wide association study of primary open-angle glaucoma in continental and admixed African populations.

Hum Genet 2018 Oct 13;137(10):847-862. Epub 2018 Oct 13.

Department of Ophthalmology, Erasmus MC, Rotterdam, The Netherlands.

Primary open angle glaucoma (POAG) is a complex disease with a major genetic contribution. Its prevalence varies greatly among ethnic groups, and is up to five times more frequent in black African populations compared to Europeans. So far, worldwide efforts to elucidate the genetic complexity of POAG in African populations has been limited. Read More

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http://dx.doi.org/10.1007/s00439-018-1943-7DOI Listing
October 2018
6 Reads

Positional Intraocular Pressure of Vitrectomized and Normal Fellow Eyes.

Korean J Ophthalmol 2018 Oct;32(5):409-416

Department of Ophthalmology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea.

Purpose: To compare posture-induced intraocular pressure (IOP) changes in vitrectomized eyes and normal eyes of patients who had vitrectomy in one eye.

Methods: A total of 31 patients older than 20 years of age who underwent vitrectomy were enrolled in the study. At least six months after vitrectomy, we measured IOP in both eyes using a rebound tonometer 10 minutes after the patient assumed sitting, supine, right lateral decubitus, and left lateral decubitus positions. Read More

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https://synapse.koreamed.org/DOIx.php?id=10.3341/kjo.2017.01
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http://dx.doi.org/10.3341/kjo.2017.0136DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6182206PMC
October 2018
1 Read

Influence of Vitrectomy-related Factors on the Outcome of Ahmed Glaucoma Valve Implantation.

Korean J Ophthalmol 2018 Oct;32(5):400-408

Department of Ophthalmology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

Purpose: To evaluate the outcome of Ahmed glaucoma valve (AGV) implantation in eyes with refractory secondary glaucoma following pars plana vitrectomy (PPV) and the associated prognostic factors.

Methods: A total of 146 eyes in 146 patients who underwent AGV implantation after PPV (followed up for ≥1 year) were included. AGV implantation was considered successful when the intraocular pressure (IOP) was 6 to 21 mmHg regardless of using IOP-lowering medication. Read More

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https://synapse.koreamed.org/DOIx.php?id=10.3341/kjo.2017.01
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http://dx.doi.org/10.3341/kjo.2017.0127DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6182216PMC
October 2018
9 Reads

Effects of Early Postoperative Intraocular Pressure after Ahmed Glaucoma Valve Implantation on Long-term Surgical Outcomes.

Korean J Ophthalmol 2018 Oct;32(5):391-399

Department of Ophthalmology and Visual Science, Seoul St. Mary's Hospital, The Catholic University of Korea College of Medicine, Seoul, Korea.

Purpose: To evaluate the long-term effects of early postoperative intraocular pressure (IOP) after Ahmed glaucoma valve (AGV) implantation on long-term surgical outcomes.

Methods: This retrospective, non-randomized study included 100 eyes of 100 patients who underwent AGV surgery. We divided the enrolled patients into four groups according to the presence of transient hypotony within the first postoperative week or the presence of a hypertensive phase during the first three postoperative months. Read More

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http://dx.doi.org/10.3341/kjo.2017.0102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6182210PMC
October 2018

Effects of Choroidal Thickness on Refractive Outcome Following Cataract Surgery in Primary Angle Closure.

Korean J Ophthalmol 2018 Oct;32(5):382-390

Department of Ophthalmology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

Purpose: To identify the preoperative biometric factors, including subfoveal choroidal thickness (CT), associated with refractive outcome after cataract surgery in eyes with primary angle closure (PAC).

Methods: This study included 50 eyes of 50 PAC patients who underwent uneventful cataract surgery. Preoperatively, anterior segment parameters including anterior chamber depth (ACD) and lens vault were determined by anterior segment optical coherence tomography. Read More

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https://synapse.koreamed.org/DOIx.php?id=10.3341/kjo.2017.01
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http://dx.doi.org/10.3341/kjo.2017.0129DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6182207PMC
October 2018
1 Read

Is a pillow a risk factor for glaucoma?

Acta Ophthalmol 2018 Dec 8;96(8):795-799. Epub 2018 Oct 8.

The Rotterdam Ophthalmic Institute, The Rotterdam Eye Hospital, Rotterdam, the Netherlands.

Purpose: To study whether a clinically significant increase in intraocular pressure (IOP) occurs during simulated sleep conditions with the subject's head turned comfortably into a pillow (the simulated sleep position) and the effect of protective glasses on any such IOP rise.

Methods: A specially developed electronic epipalpebral pressure (EPP) sensor was attached to an eyelid of the right eye of all participants: 11 patients with primary open-angle glaucoma and 11 healthy volunteers. During calibration, mechanical pressure was applied to the EPP sensor taped to the lower eyelid and the IOP was measured simultaneously at the slit lamp by Goldmann applanation tonometry. Read More

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http://doi.wiley.com/10.1111/aos.13881
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http://dx.doi.org/10.1111/aos.13881DOI Listing
December 2018
5 Reads