Search Our Scientific Publications & Authors

J Neurosci 2018 Dec 12. Epub 2018 Dec 12.

Eye Institute, Eye & ENT Hospital, State Key Laboratory of Medical Neurobiology, Institutes of Brain Science and Collaborative Innovation Center for Brain Science, Shanghai Medical College, Fudan University, Shanghai 200032, China.

Serotonin receptor agonists are neuroprotective in central nervous system (CNS) injury models. However, the neuroprotective functional implications and synaptic mechanism of 8-OH-DPAT, a serotonin receptor (5-HT1A) agonist, in an adult male Wistar rat model of chronic glaucoma model remain unknown. We found that ocular hypertension decreased 5-HT1A receptor expression in rat retinas, as the number of retinal ganglion cells (RGCs) was significantly reduced in rats with induced ocular hypertension relative to that in control retinas, and 8-OH-DPAT enhanced the RGC viability. Read More

Front Hum Neurosci 2018 22;12:426. Epub 2018 Oct 22.

Department of Ophthalmology, Huashan Hospital, Fudan University, Shanghai, China.

Ocular hypertension (OHT), the common situation in adult patients in the outpatients, occurs ∼5% worldwide. However, there are still some practical problems in differentiation of OHT with early primary open-angle glaucoma (POAG) using current standard methods. Application of high resolution diffusion tensor imaging (DTI) enables us to the differentiate axonal architecture of visual pathway between POAG and OHT subjects. Read More

Zhonghua Yan Ke Za Zhi 2018 Nov;54(11):839-842

Department of Ophthalmology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China.

To investigate the clinical features of glucocorticoid eye drops induced ocular hypertension in pediatric and adult uveitic eyes. Retrospective survey of consecutive uveitic patients attending referral service at Peking Union Medical College Hospital from March 2013 to August 2017. Incidences of glucocorticoid eye drops induced ocular hypertension were compared between the pediatric and adult uveitic groups. Read More

Biomed Res Int 2018 21;2018:4862309. Epub 2018 Oct 21.

School of Biomedical Engineering, Capital Medical University, Beijing 100069, China.

Background: The flow field of aqueous humor correlates to the stiffness of iris pigment epithelium (IPE) which acts as a wall of posterior chamber. We focus on the variations of IPE stiffness in a rat ocular hypertension (OHT) model, so as to prepare for exploring the mechanism of duration of OHT.

Methods: Episcleral venous cauterization (EVC) was applied on one eye of male adult Sprague-Dawley rats to induce chronic high intraocular pressure. Read More

Semin Ophthalmol 2018 5;33(7-8):878-885. Epub 2018 Nov 5.

a Glaucoma service , LV Prasad Eye Institute , Bhubaneswar , India.

Purpose: To characterize anatomical dimensions of a disc notch using novel methods using spectral domain optical coherence tomography (SD-OCT).

Participants: All age- and severity-matched glaucoma patients with disc notch (defined as complete loss of neural rim with no residual rim between disc and cup) seen from 2014 to 2015 who underwent enhanced depth imaging with SD-OCT (Cirrus HD-OCT version 6.5, Carl Zeiss, USA) were included for this retrospective observational study. Read More

BMC Ophthalmol 2018 Oct 29;18(1):279. Epub 2018 Oct 29.

Department of Ophthalmology, University of Jordan Hospital, The University of Jordan, Amman, 11942, Jordan.

Background: Central corneal thickness (CCT) has long been implicated to affect glaucoma predisposition. Several reports have identified that thinner CCT is a risk factor for open-angle glaucoma, and that CCT can be very variable between different ethnic groups. In this study, we aim to identify the relation between CCT and different glaucoma parameters in different types of glaucoma in an Arabian ethnicity. Read More

Indian J Ophthalmol 2018 Nov;66(11):1580-1585

Advanced Eye Center, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Purpose: To study the efficacy of the Aurolab aqueous drainage implant (AADI) compared to Ahmed glaucoma valve (AGV) in patients with refractory glaucoma.

Methods: This was a prospective, randomized controlled trial. Thirty-eight adult patients (>18 years) scheduled for a glaucoma drainage device (GDD) were randomized into two groups to receive either AGV or AADI. Read More

BMC Ophthalmol 2018 Oct 22;18(1):271. Epub 2018 Oct 22.

People's Hospital of Ningxia Hui Autonomous Region, Ningxia Eye Hospital (First Affiliated Hospital of Northwest University For Nationalities), 936 Huang He East Road, Yinchuan, 750011, China.

Background: The membrane frizzled-related protein (MFRP) gene is involved in axial length (AL) regulation and MFRP mutations cause nanophthalmos; also, the hepatocyte growth factor (HGF) gene is reported to result in morphologic changes of the anterior segment and abnormal aqueous regulation that increases the risk of primary angle-closure glaucoma (PACG), while the zinc ring finger 3 (ZNRF3) gene is associated with AL. The present study investigated the association of single nucleotide polymorphisms (SNPs) in ZNRF3, HGF and MFRP with PACG in a northern Chinese population, as well as the association of these SNPs with the ocular biometric parameters of anterior chamber depth (ACD) and AL.

Methods: A total of 500 PACG patients and 720 controls were recruited. Read More

Medicine (Baltimore) 2018 Oct;97(42):e12881

Department of Ophthalmology, University of California, San Francisco, CA.

To investigate the relationship between glaucoma severity and intraocular pressure (IOP) reduction after cataract surgery in patients with medically controlled primary open-angle glaucoma (POAG).Retrospective case series.This study included glaucoma suspects (GS) and POAG patients who underwent cataract surgery and continued to use the same glaucoma medications during the postoperative period of 4 months. Read More

Eur J Pharmacol 2018 Dec 13;841:75-81. Epub 2018 Oct 13.

Department of Pharmacy, Quanzhou First Hospital, Quanzhou 362000, Fujian Province, China.

Glaucoma is a common heterogeneous eye disorder that may lead to irreversible blindness. In the present study, we examined whether etidronate, a member of bisphosphonates, may have neuroprotective effects in in vivo and in vitro rat model of glaucoma. In an in vivo setting, chronic ocular hypertension (COH) was induced in adult rat retina. Read More

Hum Genet 2018 Oct 13;137(10):847-862. Epub 2018 Oct 13.

Department of Ophthalmology, Erasmus MC, Rotterdam, The Netherlands.

Primary open angle glaucoma (POAG) is a complex disease with a major genetic contribution. Its prevalence varies greatly among ethnic groups, and is up to five times more frequent in black African populations compared to Europeans. So far, worldwide efforts to elucidate the genetic complexity of POAG in African populations has been limited. Read More

Korean J Ophthalmol 2018 Oct;32(5):409-416

Department of Ophthalmology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea.

Purpose: To compare posture-induced intraocular pressure (IOP) changes in vitrectomized eyes and normal eyes of patients who had vitrectomy in one eye.

Methods: A total of 31 patients older than 20 years of age who underwent vitrectomy were enrolled in the study. At least six months after vitrectomy, we measured IOP in both eyes using a rebound tonometer 10 minutes after the patient assumed sitting, supine, right lateral decubitus, and left lateral decubitus positions. Read More

Korean J Ophthalmol 2018 Oct;32(5):400-408

Department of Ophthalmology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

Purpose: To evaluate the outcome of Ahmed glaucoma valve (AGV) implantation in eyes with refractory secondary glaucoma following pars plana vitrectomy (PPV) and the associated prognostic factors.

Methods: A total of 146 eyes in 146 patients who underwent AGV implantation after PPV (followed up for ≥1 year) were included. AGV implantation was considered successful when the intraocular pressure (IOP) was 6 to 21 mmHg regardless of using IOP-lowering medication. Read More

Korean J Ophthalmol 2018 Oct;32(5):391-399

Department of Ophthalmology and Visual Science, Seoul St. Mary's Hospital, The Catholic University of Korea College of Medicine, Seoul, Korea.

Purpose: To evaluate the long-term effects of early postoperative intraocular pressure (IOP) after Ahmed glaucoma valve (AGV) implantation on long-term surgical outcomes.

Methods: This retrospective, non-randomized study included 100 eyes of 100 patients who underwent AGV surgery. We divided the enrolled patients into four groups according to the presence of transient hypotony within the first postoperative week or the presence of a hypertensive phase during the first three postoperative months. Read More

Korean J Ophthalmol 2018 Oct;32(5):382-390

Department of Ophthalmology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

Purpose: To identify the preoperative biometric factors, including subfoveal choroidal thickness (CT), associated with refractive outcome after cataract surgery in eyes with primary angle closure (PAC).

Methods: This study included 50 eyes of 50 PAC patients who underwent uneventful cataract surgery. Preoperatively, anterior segment parameters including anterior chamber depth (ACD) and lens vault were determined by anterior segment optical coherence tomography. Read More

Acta Ophthalmol 2018 Sep 2;96(6):573-581. Epub 2018 Oct 2.

Department of Ophthalmology, University Hospitals Leuven, Leuven, Belgium.

Purpose: To investigate the vitreopapillary interface (VPI) in health and glaucoma according to the different stages of posterior vitreous detachment (PVD) formation.

Methods: Prospective single centre study including healthy subjects and glaucoma patients. PVD staging was performed with spectral domain optical coherence tomography. Read More

BMC Ophthalmol 2018 Sep 29;18(1):259. Epub 2018 Sep 29.

Department of Ophthalmology, Guangdong General Hospital, Guangdong Academy of Medical Sciences, No. 106, The second zhongshan road, Guangzhou, 510080, Guangdong, China.

Background: Cytomegalovirus can cause ocular anterior uveitis with ocular hypertension. Basis on the therapy, ocular pressure usually can be controlled. We report a case of a man who had unilateral cytomegalovirus anterior uveitis with refractory glaucoma during the process of treatment. Read More

BMC Ophthalmol 2018 Sep 14;18(Suppl 1):219. Epub 2018 Sep 14.

Western Eye Hospital, London, UK.

Background: This case highlights the important sequelae that can occur following the inadvertent implantation of a single-piece intraocular lens into the ciliary sulcus during cataract surgery; secondary pigment dispersion glaucoma, recurrent anterior uveitis and macular oedema.

Case Presentation: A 67-year-old lady underwent routine left cataract surgery in a separate unit but subsequently attended our eye casualty with recurrent hypertensive anterior uveitis. She was found to have secondary pigment dispersion glaucoma as the intraocular lens had been inadvertently placed into the ciliary sulcus. Read More

BMC Ophthalmol 2018 Sep 14;18(Suppl 1):222. Epub 2018 Sep 14.

Western Eye Hospital, London, UK.

Background: The surgical management of patients with uncontrolled glaucoma and scleroderma is challenging, as the hostile ocular surface poses a challenge to surgery. A serious complication is tube erosion, with the risk of subsequent endophthalmitis. Here, we present a novel technique of harvesting autologous tissue to successfully manage recurrent tube extrusion. Read More

BMC Ophthalmol 2018 Sep 14;18(Suppl 1):224. Epub 2018 Sep 14.

Sunderland Eye Infirmary, Sunderland, UK.

Background: Suprachoroidal haemorrhage is a rare complication of either medical anticoagulation treatment or intraocular surgical procedures. Suprachoroidal haemorrhages often have devastating visual outcome despite conservative and/or surgical intervention.

Case Presentation: A patient with known Open Angle Glaucoma and Atrial Fibrillation on warfarin presents symptoms and signs suggestive acute angle closure. Read More

BMC Ophthalmol 2018 Sep 14;18(Suppl 1):229. Epub 2018 Sep 14.

Princess Alexandra Eye Pavilion, Edinburgh, Scotland.

Background: We present a case of aphakic pupil block caused by vitreous prolapse into the anterior chamber following Nd:YAG capsulotomy.

Case Presentation: This resulted in advanced glaucoma in a young patient, which presented a significant clinical management challenge.

Conclusions: Ultimately, at the time of writing, her intraocular pressure and uveitis were well controlled, however the long-term outcome remains uncertain, given the uncompromising natural history of her complicated ocular condition. Read More

Graefes Arch Clin Exp Ophthalmol 2018 Dec 24;256(12):2391-2398. Epub 2018 Sep 24.

Department of Ophthalmology, School of Medicine, University of Pittsburgh, 203 Lothrop St., Pittsburgh, PA, 15213, USA.

Purpose: To investigate the relationship of lamina cribrosa displacement to corneal biomechanical properties and visual function after mitomycin C-augmented trabeculectomy.

Method: Eighty-one primary open-angle eyes were imaged before and after trabeculectomy using an enhanced depth spectral domain optical coherence tomography (SDOCT). Corneal biomechanical properties were measured with the ocular response analyzer before the surgery. Read More

Graefes Arch Clin Exp Ophthalmol 2018 Dec 24;256(12):2407-2411. Epub 2018 Sep 24.

Nottingham University Hospital, Nottingham, NG7 2UH, UK.

Purpose: To identify the key set of glaucoma surgery outcome measures considered most important and practical to collect by glaucoma specialists.

Methods: One hundred two glaucoma specialists (57 members of the UK and Eire Glaucoma Society (UKEGS) and 45 members of the European Glaucoma society (EGS)) took part in an Online Delphi exercise. The RAND/UCLA appropriateness method was used analyse data from each round and generate a disagreement index. Read More

Indian J Ophthalmol 2018 Oct;66(10):1429-1434

Guru Nanak Eye Centre, New Delhi, India.

Purpose: To report long-term safety and efficacy of trabeculectomy with collagen implant in Indian population.

Methods: All cases of trabeculectomy with Ologen Collagen Matrix implant performed over a 7-year period from May 2008 through April 2015 at a tertiary referral institute were reviewed. A total of 30 eyes of 28 patients were included in the study with two patients undergoing bilateral trabeculectomy. Read More

Acta Ophthalmol 2018 Sep 21;96(6):567-572. Epub 2018 Sep 21.

Department of Clinical Sciences in Malmö, Ophthalmology, Lund University, Malmö, Sweden.

Purpose: To study newly diagnosed glaucoma patients given mono- or multi-therapy regarding differences in initial intraocular pressure (IOP) reduction, target IOP levels reached and influence of untreated baseline IOP on IOP reduction.

Methods: Patients newly diagnosed with manifest primary open-angle glaucoma and included in the Glaucoma Intensive Treatment Study (GITS) were randomized to immediate intensive treatment with any of three different IOP-lowering substances supplied in two bottles plus 360° laser trabeculoplasty or to conventional stepwise treatment starting with a single-drug. Intraocular pressure reduction was analysed 1 month after initiation of treatment. Read More

Semin Ophthalmol 2018 21;33(7-8):829-837. Epub 2018 Sep 21.

a Department of Ophthalmology , Mayo Clinic , Rochester , MN , USA.

Purpose: To determine the effect of a glaucoma team care model on resource utilization and efficiency in glaucoma management.

Methods: Retrospective cohort study of 358 patients diagnosed and treated for glaucoma. Analysis included number of patient visits, diagnostic tests, and glaucoma procedures performed before (2005-2007) and after (2008-2010) implementation of a team care model in 2008. Read More

Medicine (Baltimore) 2018 Sep;97(38):e12357

Division of Vitreous and Retina, Department of Ophthalmology, St Vincent's Hospital, College of Medicine, Catholic University of Korea, Suwon.

Due to the rapidly increasing life-expectancy, the prevalence of glaucoma has increased steadily in recent years. We aimed to evaluate the patterns of care and primary treatment strategy patterns in Korea according to glaucoma subtypes to assess the quality of care for glaucoma patients.In this serial cross-sectional survey, the claims data from the Korean National Health Insurance Service was used to identify and group glaucoma patients into primary open-angle glaucoma (POAG), primary angle-closure glaucoma (PACG), other types of glaucoma, and ocular hypertension from 2002 to 2013. Read More

Jpn J Ophthalmol 2018 Nov 18;62(6):634-642. Epub 2018 Sep 18.

Department of Ophthalmology, Seoul National University Hospital, 101, Daehak-Ro Jongno-Gu, Seoul, 03080, Republic of Korea.

Purpose: To compare the diagnostic capability of three-dimensional (3D) neuro-retinal rim thickness (NRR) with existing optic nerve head and retinal nerve fiber layer (RNFL) scan parameters using high-definition optical coherence tomography (HD-OCT).

Design: Retrospective study.

Methods: Based on the mean deviation (MD) of the Humphrey Field Analyzer (HFA), the 152 subjects were categorized into mild (MD > - 6 dB, 100), moderate (MD - 6 to - 12 dB, 26), and severe (MD < - 12 dB, 26) glaucoma. Read More

Cornea 2018 Dec;37(12):1484-1489

Ophthalmology Department, King's College Hospital, London, United Kingdom.

Purpose: High intraocular pressure (IOP) is common in association with intracameral air and gas tamponade after Descemet membrane endothelial keratoplasty (DMEK); yet its influence on endothelial cell survival is unknown. Our aim was to determine the effect of high IOP measured 2 hours after DMEK on 1-month endothelial cell density (ECD). The influence of other potentially relevant factors was also investigated. Read More

Cornea 2018 Nov;37 Suppl 1:S78-S85

Department of Ophthalmology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan.

Purpose: To restore vision in complex eyes with coexisting anterior and posterior segment problems, combined corneal transplantation (penetrating keratoplasty [PK] or Descemet-stripping automated endothelial keratoplasty [DSAEK]), pars plana vitrectomy (PPV), and/or flanged intrascleral intraocular lens (IOL) fixation, designated vitreocorneal surgery are performed. In this study, we evaluated the usefulness of vitreocorneal surgery for eyes with complex comorbidities.

Methods: Thirteen consecutive eyes in 13 patients with coexisting corneal pathology (ie, corneal scarring, bullous keratoplasty, corneal laceration) and posterior segment pathology (ie, aphakia without capsular support, retinal detachment, intravitreal foreign body) underwent vitreocorneal surgery. Read More

Cornea 2018 Dec;37(12):1522-1526

Eye Clinic, Department of Neurosciences, Reproductive Sciences and Dentistry, University of Naples "Federico II," Naples, Italy.

Purpose: To measure corneal epithelial thickness (CET) in patients with glaucoma using anterior-segment optical coherence tomography and to evaluate CET changes in relation to corneal epithelial microvilli analyzed by scanning electron microscopy (SEM).

Methods: Twenty-two eyes (16 patients) being treated with preservative-containing topical medications and 12 normal eyes underwent anterior-segment optical coherence tomography imaging using RTVue-100. The CET maps generated corresponded to a 6-mm diameter area of cornea that was divided into 17 sectors. Read More

BMC Ophthalmol 2018 Sep 10;18(1):243. Epub 2018 Sep 10.

Department of Ophthalmology, Kagawa University Faculty of Medicine, 1750-1 Ikenobe, Miki, Kagawa, 761-0793, Japan.

Background: To compare trabeculectomy and EX-PRESS device implantation procedures for treating glaucoma and evaluate changes in corneal endothelial cell density (CECD).

Methods: This study prospectively evaluated changes in the CECD in 60 eyes of 60 patients who underwent trabeculectomy and 50 eyes of 45 patients who underwent EX-PRESS device implantation. Baseline patient data recorded included age at surgery, sex, type of glaucoma medications, and lens status. Read More

BMJ Case Rep 2018 Sep 5;2018. Epub 2018 Sep 5.

Faculty of Medicine, SEGi University, Sibu, Sarawak, Malaysia.

We report a case of a 70-year-old farmer admitted for viper bite who presented with bilateral hyphema and angle closure attack. He was managed conservatively with topical steroids and cycloplegics. He responded well and was discharged after 2 weeks. Read More

Ophthalmic Res 2018 5;60(3):161-168. Epub 2018 Sep 5.

Purpose: The aim of this study was to evaluate the choroidal thickness (CT) and its determinants in primary angle closure glaucoma (PACG) eyes with and without malignant glaucoma (MG).

Methods: In this cross-sectional study, we enrolled 25 patients with bilateral primary angle closure (PAC) diseases; 1 eye of each patient was diagnosed with PACG initially and later with MG after trabeculectomy, and the fellow eyes were diagnosed with PACG, PAC, or PAC suspect. Thirty-seven eyes from 37 PACG patients were recruited as controls. Read More

Acta Ophthalmol 2018 Nov 4;96(7):e859-e864. Epub 2018 Sep 4.

1st Department of Ophthalmology, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece.

Purpose: To assess the overdiagnosis of open-angle glaucoma (OAG) and to investigate associated factors.

Methods: This was a cross-sectional, population-based study of an urban Caucasian population in northern Greece. Randomly selected subjects ≥60 years (n = 2554) participated in the Thessaloniki Eye Study. Read More

BMC Ophthalmol 2018 Sep 3;18(1):233. Epub 2018 Sep 3.

Department of Medicine and Healthy Sciences, Università del Molise, Campobasso, Italy.

Background: To evaluate differences of intraocular pressure (IOP) measurements performed with Goldmann applanation tonometer (GAT), dynamic contour tonometer (DCT), rebound tonometry (RT), Ocular Response Analyzer (ORA) and Corvis ST (CST) in eyes screened for refractive surgery.

Methods: One eye, only the right one, of 146 patients was included in this study. Each participant was submitted to a corneal analysis with Scheimpflug camera and IOP evaluation with GAT, DCT, RT, ORA and CST. Read More

Acta Ophthalmol 2018 Sep 31;96(6):557-566. Epub 2018 Aug 31.

Department of Clinical Sciences, Ophthalmology, Umeå University, Umeå, Sweden.

Purpose: The primary objective of the ongoing Glaucoma Intensive Treatment Study (GITS) is to evaluate the effectiveness of immediate intensive treatment in comparison with the commonly recommended stepped regimen on the predicted visual field. The two treatment arms are also being compared regarding quality of life (QoL), intraocular pressure (IOP) reduction, frequency of reported side-effects, adverse events and adherence to prescribed treatment.

Design: A randomized, two-centre, prospective open-labelled treatment trial for open-angle glaucoma. Read More

Graefes Arch Clin Exp Ophthalmol 2018 Nov 31;256(11):2191-2200. Epub 2018 Aug 31.

Department of Ophthalmology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, 2630 Sugitani, Toyama, 930-0194, Japan.

Purpose: We compared the outcomes of Baerveldt glaucoma implant (BGI) surgery between vitreous cavity and anterior chamber insertion.

Methods: We retrospectively analyzed a total of 105 consecutive eyes that underwent BGI surgery and were followed up for ≥ 12 months. BGI surgery was performed via the anterior chamber (AC group 48 eyes) or the pars plana into the vitreous cavity (VC group 57 eyes). Read More

BMC Ophthalmol 2018 Aug 31;18(1):226. Epub 2018 Aug 31.

FEBO, Dunyagoz Hospital, Istanbul, Turkey.

Background: To describe a new technique and present its long-term outcome for prevention of Ahmed glaucoma valve (AGV) tube exposure in patients with refractory glaucoma.

Methods: Twenty-seven eyes of 24 patients (mean age, 50 years; age range, 16-78 years; 8 females, 16 males) with refractory glaucoma who had the AGV implant were retrospectively reviewed. For AGV implantation, a long scleral flap combined with Tenon advancement and duplication was used. Read More

Neurologist 2018 Sep;23(5):157-159

Neurology, AZ Maria Middelares.

Introduction: Wall-eyed bilateral internuclear ophthalmoplegia (WEBINO) is a variant syndrome of internuclear ophthalmoplegia, consisting of primary gaze exotropia, adduction impairment, nystagmus of the abducting eye, and vertical gaze-evoked nystagmus. It seems to be most frequently associated with multiple sclerosis, although other etiologies such as brainstem ischemia or hydrocephalus have also been described.

Case Report: We report the case of a 25-year-old woman who presented with subacute progressive oculomotor disturbances, resulting in the development of a WEBINO over a few days. Read More

Cornea 2018 Nov;37(11):1400-1407

Stein Eye Institute, David Geffen School of Medicine at UCLA, Los Angeles, CA.

Purpose: To report the outcomes of the Boston type I keratoprosthesis (KPro) as the primary penetrating corneal procedure.

Methods: In this retrospective review of all KPro procedures performed by 2 surgeons from May 1, 2004, to December 31, 2015, indications and outcomes were compared between KPros performed as the primary keratoplasty procedure (primary KPro) versus after failed keratoplasty (previous keratoplasty).

Results: A total of 262 KPros were implanted in 231 eyes, including 67 primary KPro procedures. Read More

Medicine (Baltimore) 2018 Aug;97(34):e11960

State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center at Sun Yat-sen University, Guangzhou, China.

Background: Anti-VEGF agents has been widely used in ocular diseases, but its safety for treating anterior segment disorders, the conclusions are controversial.

Methods: Several major databases, including CENTRAL, MEDLINE, and EMBASE, were searched. Safety data from 18 randomized controlled trials (RCTs) were used to compare anti-VEGF treatment in the ocular anterior segment in pterygium and neovascular glaucoma treatment with placebo/sham treatment for eye diseases. Read More

Medicine (Baltimore) 2018 Aug;97(34):e11824

Glaucoma Department, 1 Athens University Eye Clinic "G.Gennimatas" General Hospital, Greece.

The purpose of this study was to objectively evaluate the anterior chamber depth (ACD) after trabeculectomy and to correlate its variations with the intraocular pressure (IOP) and bleb functionality.Fifty eyes (46 patients) were included in this prospective study. ACD was documented with the use of a non-contact optical device (IOL Master-Carl Zeiss Meditec) and IOP was measured with the Goldmann applanation tonometer. Read More

BMC Ophthalmol 2018 Aug 23;18(1):207. Epub 2018 Aug 23.

Department of Ophthalmology, Peking University First Hospital, 8 Xi Shi Ku Street, Xi Cheng District, Beijing, 100034, People's Republic of China.

Background: Idiopathic elevated episcleral venous pressure (IEEVP) or idiopathic dilated episcleral veins (IDEV) is a rare abnormality, and thus therapeutic treatment for this condition rarely is discussed. We report a case of a patient with bilateral glaucoma secondary to IDEV for whom intraocular pressures (IOPs) were controlled successfully by trabeculectomy.

Case Presentation: A 50 year-old female with a complaint of persistent red eyes for over 30 years, presented with numerous tortuous and engorged episcleral vessels in both eyes (OU), open angles OU with spontaneous blood in Schlemm's canal 360 degrees bilaterally. Read More

Graefes Arch Clin Exp Ophthalmol 2018 Nov 21;256(11):2181-2189. Epub 2018 Aug 21.

Ophthalmology Department, Hawke's Bay Fallen Soldiers' Memorial Hospital, Hastings, New Zealand.

Purpose: To produce an economic comparison of the iStent ab interno trabecular microbypass implant accompanying cataract surgery and selective laser trabeculoplasty (SLT) as first-line treatment versus topical medications for open-angle glaucoma in New Zealand in 2016.

Methods: The current annual costs of 19 available fully subsidised topical glaucoma medications by Pharmaceutical Management Agency (Pharmac) in 2016 were identified. Adjustments for pharmacist prescribing charges and previously described wastage levels were applied. Read More

Indian J Ophthalmol 2018 09;66(9):1345-1349

Department of Vitreo Retina, Aditya Birla Sankara Nethralaya, Kolkata, West Bengal, India.

Glaucoma is a progressive optic neuropathy associated with irreversible loss of retinal ganglion cells (RGC). This emblematic localized retinal nerve fiber layer defect (RNFLD) can be the earliest sign to detect the ongoing glaucomatous damage. Slitlamp biomicroscopy [90D & 78D], colour and redfree fundus photography, OCT & HRT are used conventionally for early detection of RNFLD. Read More

Indian J Ophthalmol 2018 09;66(9):1342-1344

Cataract and Refractive Surgeries, Narayana Nethralaya, Bangalore, Karnataka, India.

A 36-year-old female presented with the complaints of pain, photophobia, redness, and sudden diminution of vision in both the eyes following topiramate for migraine treatment. On examination, there was panuveitis with angle-closure glaucoma in both the eyes with fibrinous exudate with pigments in the anterior chamber of the left eye. B scan revealed increased choroidal thickness in both the eyes. Read More

Indian J Ophthalmol 2018 09;66(9):1339-1341

VST Glaucoma Center, L V Prasad Eye Institute, Hyderabad, Telangana, India.

Pigment dispersion and elevated intraocular pressure (IOP) with sulcus placed hydrophobic acrylic intraocular lenses (IOLs) are described and are rare with in-the-bag IOLs. We report a case of a young lady with elevated IOP and pigment dispersion in one eye following an uneventful phacoemulsification and multifocal IOL implantation. The eye had eccentric capsulorrhexis and localized capsular fibrosis with anterior displacement of the IOL optic, resulting in pigment dispersion. Read More

Indian J Ophthalmol 2018 09;66(9):1285-1290

Glaucoma Service, B B Eye Foundation, Kolkata, West Bengal, India.

Purpose: To estimate the prevalence, features, and associations of primary angle closure disease (PACD) in rural and urban populations from West Bengal in eastern India.

Methods: This was a population-based cross-sectional study with two arms, rural and urban. The rural study area consisted of 28 contiguous villages from 13 gram panchayats in Balagarh Police Station, with rural base hospital at Dhobapara, Balagarh Police Station, in the village Kuliapara of Hooghly district. Read More

Indian J Ophthalmol 2018 09;66(9):1284

Department of Glaucoma, Centre for Sight, Safadarjung Enclave, New Delhi, India.