444 results match your criteria Glaucoma Secondary Congenital


Characteristics of Pediatric Glaucoma in a Latin American Reference Center.

J Curr Glaucoma Pract 2020 Jan-Apr;14(1):10-15

Fundación Oftalmológica Nacional, Bogota, Colombia.

Aim: To describe the clinical and epidemiological characteristics of children with pediatric glaucoma (PG) treated in an ophthalmologic national reference center.

Materials And Methods: A retrospective study of patients diagnosed with PG in a national ophthalmologic reference center was made, between 2005 and 2015. Clinical findings, type of treatment, and the follow-up were evaluated. Read More

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http://dx.doi.org/10.5005/jp-journals-10078-1267DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7302610PMC

Non-Penetrating Deep Sclerectomy versus Trabeculectomy in Primary Congenital Glaucoma.

Clin Ophthalmol 2020 12;14:1277-1285. Epub 2020 May 12.

Ophthalmology Department, Faculty of Medicine, Alexandria University, Alexandria, Egypt.

Purpose: To evaluate the safety and efficacy of non-penetrating deep sclerectomy with a collagen implant versus trabeculectomy in primary congenital glaucoma.

Subjects And Methods: This was a retrospective interventional comparative non-randomized clinical study that included 80 eyes of 80 children presenting with primary congenital glaucoma under the age of 3 years. Forty eyes have undergone non-penetrating deep sclerectomy (NPDS) and the other 40 eyes have undergone penetrating trabeculectomy. Read More

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http://dx.doi.org/10.2147/OPTH.S253689DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7229790PMC

Transcriptome analysis of neural progenitor cells derived from Lowe syndrome induced pluripotent stem cells: identification of candidate genes for the neurodevelopmental and eye manifestations.

J Neurodev Disord 2020 May 11;12(1):14. Epub 2020 May 11.

Department of Genetics, Albert Einstein College of Medicine, Bronx, New York, USA.

Background: Lowe syndrome (LS) is caused by loss-of-function mutations in the X-linked gene OCRL, which codes for an inositol polyphosphate 5-phosphatase that plays a key role in endosome recycling, clathrin-coated pit formation, and actin polymerization. It is characterized by congenital cataracts, intellectual and developmental disability, and renal proximal tubular dysfunction. Patients are also at high risk for developing glaucoma and seizures. Read More

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http://dx.doi.org/10.1186/s11689-020-09317-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7212686PMC

Outcomes of Ahmed glaucoma valve in paediatric glaucoma following congenital cataract surgery in persistent foetal vasculature.

Eur J Ophthalmol 2020 Apr 30:1120672120919066. Epub 2020 Apr 30.

Hospital Universitario La Paz, Madrid, Spain.

Purpose: To evaluate the outcomes of primary Ahmed glaucoma valve in refractory secondary glaucoma following congenital cataract surgery, particularly in persistent foetal vasculature.

Method: Retrospective review of paediatric patients after Ahmed glaucoma valve implantation for refractory post-lensectomy glaucoma in a tertiary referral centre in Spain. Surgical complications, additional and/or replacements of Ahmed glaucoma valve, intraocular pressure, cup-to-disc ratio, glaucoma medications and final visual acuity were studied. Read More

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http://dx.doi.org/10.1177/1120672120919066DOI Listing

Severity of visual field defects in primary congenital glaucoma and their risk factors.

Graefes Arch Clin Exp Ophthalmol 2020 Jul 15;258(7):1483-1491. Epub 2020 Apr 15.

Department of Biostatistics, All India Institute of Medical Sciences, New Delhi, 110029, India.

Purpose: The primary objective of the study was to assess the frequency and severity of visual field defects (VFD) in primary congenital glaucoma (PCG). The secondary objective was to ascertain any associated risk factors.

Methods: An ambispective review of patients with PCG on follow-up with a 'target' intraocular pressure (IOP) of ≤ 15 mmHg. Read More

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http://dx.doi.org/10.1007/s00417-020-04677-wDOI Listing
July 2020
1.908 Impact Factor

The Swedish National Pediatric Cataract Register (PECARE): incidence and onset of postoperative glaucoma.

Acta Ophthalmol 2020 Apr 9. Epub 2020 Apr 9.

Department of Ophthalmology, Region Västra Götaland, Sahlgrenska University Hospital, Mölndal, Sweden.

Purpose: The aim was to report cumulative incidence and time of onset of postoperative glaucoma in a paediatric early cataract surgery cohort.

Methods: Data were retrieved from the Pediatric Cataract Register (PECARE), a prospective register of Swedish cataract operations before 8 years of age. All eyes with surgery between January 2007 and December 2014 and a registered follow-up were included. Read More

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http://dx.doi.org/10.1111/aos.14414DOI Listing

A retrospective histologic study of 140 cases of clinically significant equine ocular disorders.

J Vet Diagn Invest 2020 May 24;32(3):382-388. Epub 2020 Mar 24.

Department of Pathobiological Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA (Flores, Del Piero, Langohr).

Ocular diseases are an important category in equine medicine; however, most articles regarding histologic ocular lesions in horses are exclusive to a specific condition and do not provide a complete review of clinically significant ocular disease frequency in a diagnostic laboratory. We reviewed sections of equine eyes from 140 cases (98 enucleations [biopsies] and 42 autopsies) with clinically relevant ocular alterations at 2 diagnostic centers in the United States. The most common primary conditions were non-traumatic keratitis (36), equine recurrent uveitis (ERU; 31), traumatic injuries (22), ocular and periocular neoplasms (19), and uveitis and/or endophthalmitis resulting from sepsis (18). Read More

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http://dx.doi.org/10.1177/1040638720912698DOI Listing

Glaucoma as the presenting sign of intraocular tumors: beware of the masquerading sign.

Int Ophthalmol 2020 Jul 20;40(7):1789-1795. Epub 2020 Mar 20.

Ophthalmic Plastic Surgery and Ocular Oncology Services, The Operation Eyesight Universal Institute for Eye Cancer, LV Prasad Eye Institute, Hyderabad, 500034, India.

Purpose: To discuss the clinical presentation and management of intraocular tumors masquerading as primary glaucoma or non-tumor-related secondary glaucoma.

Methods: Retrospective chart review.

Results: Ten patients with unsuspected intraocular tumor were referred to glaucoma clinic with a diagnosis of primary glaucoma or non-tumor-related secondary glaucoma. Read More

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http://dx.doi.org/10.1007/s10792-020-01348-xDOI Listing

Retinal Pigment Epithelium Cell Density and Bruch's Membrane Thickness in Secondary versus Primary High Myopia and Emmetropia.

Sci Rep 2020 Mar 20;10(1):5159. Epub 2020 Mar 20.

Augenpraxis Jonas, Heidelberg, Germany.

To assess differences between secondary high myopia (SHM) due to congenital glaucoma and primary high myopia (PHM) and non-highly myopic eyes (NHM) in the relationships between axial length and Bruch's membrane (BM) thickness and retinal pigment epithelium (RPE) density. The histomorphometric study included human globes enucleated for reasons such as malignant uveal melanoma, end-stage painful secondary angle-closure glaucoma and congenital glaucoma. BM thickness and RPE cell density were measured upon light microscopy. Read More

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http://dx.doi.org/10.1038/s41598-020-62096-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7083925PMC

Trabeculotomy versus combined trabeculotomy-trabeculectomy for primary congenital glaucoma: study protocol of a randomised controlled trial.

BMJ Open 2020 02 25;10(2):e032957. Epub 2020 Feb 25.

State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China

Introduction: Trabeculotomy and combined trabeculotomy-trabeculectomy (CTT) are major surgical options for primary congenital glaucoma (PCG). However, it is unclear which of these two surgical procedures should be recommended as the optimum first-line treatment for PCG. This trial aims to determine whether the outcomes of trabeculotomy are non-inferior to those of CTT in moderate PCG with a horizontal corneal diameter (HCD) of 12-14 mm. Read More

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http://dx.doi.org/10.1136/bmjopen-2019-032957DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7045219PMC
February 2020
2.063 Impact Factor

Congenital corneal blood staining secondary to hemorrhagic persistent fetal vasculature.

J AAPOS 2020 Feb 11;24(1):51-53. Epub 2020 Jan 11.

Department of Ophthalmology, Icahn School of Medicine at Mount Sinai, New York, New York.

An African American girl born at 37 weeks via spontaneous vaginal delivery to a 33-year-old woman was noted on delivery to have a unilateral absent red reflex in the right eye, which was enlarged. Intraocular pressure was elevated, and the cornea had a straw-colored opacity. B-scan ultrasonography of the right eye showed diffuse hyperechoic vitreous opacities and a retrolental mass, with a hyperechoic band stretching from the optic disk to the posterior lens. Read More

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http://dx.doi.org/10.1016/j.jaapos.2019.11.007DOI Listing
February 2020

Rate of Complete Catheterization of Schlemm's Canal and Trabeculotomy Success in Primary and Secondary Childhood Glaucomas.

Am J Ophthalmol 2020 04 11;212:69-78. Epub 2019 Dec 11.

Department of Ophthalmology and Visual Sciences, Kellogg Eye Center, University of Michigan, Ann Arbor, Michigan, USA. Electronic address:

Purpose: Despite the increasing use of microcatheters to perform 360-degree trabeculotomy, the rate of complete Schlemm's canalization in different forms of pediatric glaucoma is under-reported.

Design: Retrospective institutional observational case series.

Methods: Ocular diagnoses and surgical details of 60 pediatric patients (≤18 years old) who underwent trabeculotomy between 2013 and 2019 were collected. Read More

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http://dx.doi.org/10.1016/j.ajo.2019.11.029DOI Listing

Successful Treatment of Corneal Opacification with Associated Thickened Epithelium by Simple Peeling: Acquired Corneal Subepithelial Hypertrophy (ACSH).

Saudi J Ophthalmol 2019 Jul-Sep;33(3):203-208. Epub 2019 Feb 13.

Specialized Experts Center, Riyadh, Saudi Arabia.

Purpose: To study clinical and histopathological findings of corneal opacification caused by thickened epithelium leading to reduced vision and topographical changes and to evaluate the outcome of its removal.

Methods: Twelve patients (17 eyes) with central, paracentral or peripheral corneal opacification were reviewed to obtain their visual acuity, describe their slit lamp (SL) appearance (depth, extent and density) and document their topographic changes before and after peeling of the epithelium under SL or surgical removal under the microscope. Specimens of six cases were available for histopathological examination and immunohistochemical staining. Read More

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http://dx.doi.org/10.1016/j.sjopt.2019.02.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6819717PMC
February 2019

Congenital choroidal melanocytoma in a child with ocular melanocytosis.

BMJ Case Rep 2019 Oct 30;12(10). Epub 2019 Oct 30.

Ocular Oncology, LV Prasad Eye Institute, Hyderabad, India

A 1-day-old child was brought to the clinic for evaluation of enlarged right eye (OD). On examination, OD showed buphthalmos with diffuse scleral melanocytosis, fleshy blackish-brown extrascleral mass with corneal extension, and secondary glaucoma. Anterior segment evaluation revealed darkly pigmented iris and fundus evaluation OD revealed a darkly pigmented choroidal lesion. Read More

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http://dx.doi.org/10.1136/bcr-2019-231376DOI Listing
October 2019

Retinoschisis: splitting hairs on retinal splitting.

Authors:
Emily R Carr

Clin Exp Optom 2019 Oct 29. Epub 2019 Oct 29.

Department of Optometry, Wilmington Veterans Affairs Medical Center, Wilmington, Delaware, USA.

Retinoschisis can be found in the fovea or the retinal periphery, either of which may be present in isolation, or in conjunction with each other. Foveal schisis may be congenital, acquired, or secondary to an associated ocular pathology such as optic pit, glaucoma, or pathological myopia. The visual acuity is dependent on the cause of the schisis and appropriate treatment is variable based on likelihood for progression and visual impact. Read More

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http://dx.doi.org/10.1111/cxo.12977DOI Listing
October 2019

Glaucoma in Ectropion Uveae Syndrome: A Case Report and Literature Review.

J Ophthalmic Vis Res 2019 Jul-Sep;14(3):370-375. Epub 2019 Jul 18.

Ophthalmic Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Purpose: To report a case of advanced childhood glaucoma secondary to congenital ectropion uveae (CEU).

Case Report: The patient was a seven-year-old boy with unilateral glaucoma secondary to CEU and facial asymmetry, mild unilateral ptosis, and proptosis in the left eye. The intraocular pressure (IOP) was 28 mmHg and cup-to-disc ratio was 0. Read More

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http://dx.doi.org/10.18502/jovr.v14i3.4793DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6815341PMC

Optical Coherence Tomography Findings After Childhood Lensectomy.

Invest Ophthalmol Vis Sci 2019 10;60(13):4388-4396

National Institute of Health Research Moorfields Biomedical Research Centre, London, United Kingdom.

Purpose: To explore the impact of childhood lensectomy on posterior segment development.

Methods: Cross-sectional observational study at children's eye clinics at a tertiary referral center in London, UK. We included 45 children age 4 to 16 years with healthy eyes and 38 who had undergone lensectomy. Read More

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http://dx.doi.org/10.1167/iovs.19-26806DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6798320PMC
October 2019

Glaucoma following cataract surgery in the first 2 years of life: frequency, risk factors and outcomes from IoLunder2.

Br J Ophthalmol 2020 Jul 5;104(7):967-973. Epub 2019 Oct 5.

National Institute for Health Research Biomedical Research Centre, UCL Great Ormond Street Institute of Child Health and Great Ormond Street Hospital, London, UK

Background: We investigated glaucoma related adverse events, predictors and impact at 5 years following surgery in the IoLunder2 cohort METHODS: Population based observational cohort study of children undergoing cataract surgery aged 2 years or under between January 2009 and December 2010. Glaucoma was defined using internationally accepted taxonomies based on the consequences of elevated intraocular pressure (IOP). Glaucoma related adverse events were any involving elevated IOP. Read More

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http://dx.doi.org/10.1136/bjophthalmol-2019-314804DOI Listing
July 2020
1 Read

Intraocular lens implantation as an isolated risk factor for secondary glaucoma in pediatric patients.

Can J Ophthalmol 2019 10 16;54(5):621-625. Epub 2019 Feb 16.

Department of Ophthalmology, Soroka University Medical Center, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.

Objective: To evaluate the effect of intraocular lens (IOL) implantation on the development of secondary glaucoma after cataract surgery in pediatric patients.

Design: Retrospective case series study.

Methods: This study reviewed the medical records of children under 16 years of age who had undergone cataract surgery from 1996 to 2016 for congenital or developmental cataract. Read More

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http://dx.doi.org/10.1016/j.jcjo.2019.01.003DOI Listing
October 2019
2 Reads

Repeat keratoplasty in failed Descemet stripping automated endothelial keratoplasty.

Indian J Ophthalmol 2019 10;67(10):1586-1592

Cornea, Cataract and Refractive Surgery Services, Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India.

Purpose: To evaluate the clinical factors associated with repeat Descemet stripping automated endothelial keratoplasty (DSAEK) or penetrating keratoplasty (PKP) in cases of failed DSAEK.

Methods: Retrospective observational study of cases with failed DSAEK admitted to our center for a repeat keratoplasty over 5 years (January 2013-Decemeber 2017) was undertaken. Demographic and perioperative details of all cases and type of repeat keratoplasty were recorded. Read More

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http://dx.doi.org/10.4103/ijo.IJO_1729_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6786136PMC
October 2019
2 Reads

Beyond Intraocular Pressure: Visual Functioning and Quality of Life in Primary Congenital Glaucoma and Secondary Childhood Glaucoma.

Am J Ophthalmol 2020 01 13;209:62-70. Epub 2019 Sep 13.

Jasti V. Ramanamma Children's Eye Care Centre, LV Prasad Eye Institute, Hyderabad, India. Electronic address:

Purpose: To compare the visual functioning (VF) and vision-related QoL (VRQoL) of children 8-18 years old treated for primary congenital glaucoma (PCG) and secondary childhood glaucoma.

Design: Cross-sectional study.

Methods: A total of 309 children 8-18 years old treated for PCG and secondary childhood glaucoma between 2000 and 2010 by a single pediatric glaucoma specialist were prospectively enrolled at LV Prasad Eye Institute, Hyderabad, India. Read More

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http://dx.doi.org/10.1016/j.ajo.2019.09.002DOI Listing
January 2020
1 Read
3.871 Impact Factor

Secondary glaucoma and visual outcome after paediatric cataract surgery with primary bag-in-the-lens intraocular lens.

Acta Ophthalmol 2020 May 11;98(3):296-304. Epub 2019 Sep 11.

Department of Ophthalmology, Region Västra Götaland, Sahlgrenska University Hospital, Mölndal, Sweden.

Purpose: To determine predictors of secondary glaucoma and poor visual outcome in children undergoing cataract surgery with bag-in-the-lens (BIL)-IOL implantation.

Methods: Medical records were retrospectively analysed for children with primary implantation with BIL-IOL during 2009-2013.

Results: The study included 109 eyes. Read More

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http://dx.doi.org/10.1111/aos.14244DOI Listing
May 2020
1 Read

Short- and Long-term Results of Glaucoma Valve Implantation for Aniridia-related Glaucoma: A Case Series and Literature Review

Turk J Ophthalmol 2019 09;49(4):183-187

Ankara Training and Research Hospital, Ophthalmology Clinic, Ankara, Turkey

Objectives: To report the results obtained from glaucoma drainage device (GDD) implantation in patients with aniridia-related glaucoma and to review the literature.

Materials And Methods: We retrospectively reviewed 6 patients who underwent GDD implantation for glaucoma secondary to congenital aniridia between April 2001 and February 2015. Data on age at surgery, gender, laterality, surgeries before GDD implantation, GDD model, concomitant ocular disorders, visual acuity, and intraocular pressure (IOP) values before and at 1 and 12 months after GDD implantation, medications, follow-up period, findings during last visit, complications, and course of disease were collected. Read More

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http://dx.doi.org/10.4274/tjo.galenos.2019.07348DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6761385PMC
September 2019
2 Reads

XEN-augmented Baerveldt Implantation for Refractory Childhood Glaucoma: A Retrospective Case Series.

J Glaucoma 2019 11;28(11):1015-1018

Department of Ophthalmology, University Medical Center, Mainz, Germany.

Background: Tube implants can lead to long-term decompensation of the cornea after decades, in particular in complicated childhood glaucoma, because of a variety of causes including contact between the tube tip and the corneal endothelium. The augmentation of a XEN implant with a Baerveldt (250) tube implant, introduced 2016 by Mermoud et al for refractory glaucoma in adult patients, may reduce this risk in children. In our retrospective study, we report on the XEN-augmented Baerveldt (250) tube implant in children. Read More

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http://dx.doi.org/10.1097/IJG.0000000000001356DOI Listing
November 2019
4 Reads

Outcome of phacoemulsification in 71 cats: A multicenter retrospective study (2006-2017).

Vet Ophthalmol 2020 Jan 22;23(1):141-147. Epub 2019 Jul 22.

Dick White Referrals, Six Mile Bottom, UK.

Purpose: To assess outcome of phacoemulsification in cats.

Methods: Records of 71 cats (82 eyes) from five referral centers were reviewed. Groups were divided by cause of cataract (congenital/juvenile [n = 32], traumatic [n = 33], and secondary to uveitis [n = 6]), and group comparisons were performed for the most common complications: postoperative ocular hypertension (POH), uveitis, corneal ulceration, synechia/dyscoria, and posterior capsular opacity (PCO) in three different time periods: immediately postoperatively, at 1-90 days, and at >90 days. Read More

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http://dx.doi.org/10.1111/vop.12699DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7169341PMC
January 2020
4 Reads

Secondary glaucoma and visual axis opacification in aphakic and pseudophakic patients following congenital cataract surgery: A 28-year longitudinal case series.

Eur J Ophthalmol 2019 Jul 17:1120672119862878. Epub 2019 Jul 17.

Temple Street Children's University Hospital, Dublin, Ireland.

Purpose: To determine the incidence, timing and risk factors for glaucoma and visual axis opacification development following surgery for congenital cataract in the first year of life.

Methods: A prospective case series of all cataract surgery performed in Temple Street Children's University Hospital over a 28-year period was conducted. A total of 93 subjects (135 eyes) were analysed. Read More

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http://dx.doi.org/10.1177/1120672119862878DOI Listing
July 2019
5 Reads

[An Autopsy Case of Death After Deep Sedation of Thiopental].

J UOEH 2019 ;41(2):217-223

Department of Forensic Medicine, Faculty of Medicine, University of Occupational and Environmental Health, Japan.

The victim was a morbidly obese and bull-necked woman in her twenties. She had the disorders, due to Down's syndrome, including severe mental retardation, advanced hearing loss, congenital cataract surgery, and amblyopia at postoperative glaucoma. She was deeply sedated for rest with an intravenous drip infusion of 350 mg of thiopental (TP) for 5 minutes during an intraocular pressure examination with secondary glaucoma at a hospital. Read More

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http://dx.doi.org/10.7888/juoeh.41.217DOI Listing
December 2019
3 Reads

Selective laser trabeculoplasty versus drops for newly diagnosed ocular hypertension and glaucoma: the LiGHT RCT.

Health Technol Assess 2019 06;23(31):1-102

Research Department of Primary Care and Population Health, University College London, London, UK.

Background: Newly diagnosed open-angle glaucoma (OAG) and ocular hypertension (OHT) are habitually treated with intraocular pressure (IOP)-lowering eyedrops. Selective laser trabeculoplasty (SLT) is a safe alternative to drops and is rarely used as first-line treatment.

Objectives: To compare health-related quality of life (HRQoL) in newly diagnosed, treatment-naive patients with OAG or OHT, treated with two treatment pathways: topical IOP-lowering medication from the outset (Medicine-1st) or primary SLT followed by topical medications as required (Laser-1st). Read More

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http://dx.doi.org/10.3310/hta23310DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6627009PMC
June 2019
12 Reads

Micropulsed diode laser cyclophotocoagulation in recurrent pediatric glaucoma.

Eur J Ophthalmol 2019 Jul 1:1120672119858226. Epub 2019 Jul 1.

Ophthalmology Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt.

Purpose: To evaluate the intermediate-term efficacy and safety of micropulsed diode laser cyclophotocoagulation in recurrent pediatric glaucoma.

Patients And Methods: A prospective interventional study included children <16 years old diagnosed with recurrent glaucoma, attending Mansoura University, during the period from July 2017 to November 2017. Micropulsed diode laser sessions were performed in all the cases. Read More

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http://journals.sagepub.com/doi/10.1177/1120672119858226
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http://dx.doi.org/10.1177/1120672119858226DOI Listing
July 2019
9 Reads
1.058 Impact Factor

Effect of ocular hypertension on the pattern of retinal ganglion cell subtype loss in a mouse model of early-onset glaucoma.

Exp Eye Res 2019 08 15;185:107703. Epub 2019 Jun 15.

Department of Ophthalmology and Visual Sciences, McPherson Eye Research Institute, University of Wisconsin-Madison, Madison, WI, United States. Electronic address:

Glaucoma is a neurodegenerative disease with elevated intraocular pressure as one of the major risk factors. Glaucoma leads to irreversible loss of vision and its progression involves optic nerve head cupping, axonal degeneration, retinal ganglion cell (RGC) loss, and visual field defects. Despite its high global prevalence, glaucoma still remains a major neurodegenerative disease. Read More

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http://dx.doi.org/10.1016/j.exer.2019.107703DOI Listing
August 2019
15 Reads

Congenital glycosylation disorder: a novel presentation of coexisting anterior and posterior segment pathology and its implications in pediatric cataract management.

J AAPOS 2019 10 30;23(5):297-300. Epub 2019 May 30.

Department of Ophthalmology, Penn State Health Milton S. Hershey Medical Center, Hershey, Pennsylvania. Electronic address:

We report a case exhibiting the coexistence of anterior and posterior segment pathology in the same eye secondary to a congenital disorder of glycosylation resulting from a DPAGT1 gene mutation. This case details a novel gene mutation in a male infant found to have bilateral congenital cataracts, removed at 6 and 7 weeks of life, only to uncover bilateral retinal and optic atrophy. Our report highlights issues of surgical timing for syndrome-related pediatric cataracts, given the risks related to secondary glaucoma versus deprivation amblyopia, in an infant born with both cataracts and vision-limiting posterior segment pathology. Read More

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http://dx.doi.org/10.1016/j.jaapos.2019.05.004DOI Listing
October 2019
27 Reads

Progressive High Hypermetropic Shift as a Refractive Surprise Following Glaucoma Filtration Surgery in a Phakic Child With Early-Onset Childhood Glaucoma Associated With Axenfeld-Rieger Anomaly.

J Glaucoma 2019 08;28(8):e136-e139

L V Prasad Eye Institute, Banjara Hills, Hyderabad, India.

Purpose: We report a case of progressive high hypermetropia following glaucoma filtration surgery in a child with Axenfeld-Rieger syndrome and congenital glaucoma.

Methods/results: We report a case of a 4-day-old female child presented as a case of Axenfeld-Rieger anomaly with secondary glaucoma in both eyes (OU), who underwent combined trabeculotomy with trabeculectomy in OU at the age of 3 weeks. On postoperative third month, cornea cleared and posterior embryotoxon was noted in OU with Habb's striae in OS. Read More

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http://Insights.ovid.com/crossref?an=00061198-201908000-0001
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http://dx.doi.org/10.1097/IJG.0000000000001283DOI Listing
August 2019
5 Reads
2.427 Impact Factor

Neglected Congenital Glaucoma With Lens Coloboma.

J Glaucoma 2019 08;28(8):e140-e142

Advanced Eye Centre, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Purpose: To report a case of lens coloboma in a case of neglected primary congenital glaucoma.

Materials And Methods: A 5-year-old boy was brought by the parents with complaints of diminution of vision in both eyes noticed for 8 months. There was a history of enlargement of eyes since 1 year of age. Read More

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http://dx.doi.org/10.1097/IJG.0000000000001288DOI Listing
August 2019
14 Reads

[Glaucoma Surgery in Anterior Segment Dysgeneses].

Klin Monbl Augenheilkd 2019 Jun 2;236(6):745-750. Epub 2019 May 2.

Klinik für Augenheilkunde, Universitätsmedizin Göttingen.

Anterior segment dysgeneses are rare conditions, and mostly occur sporadically. The severity of dysgenesis and the number of structures affected are highly variable. Glaucoma occurs in approximately 50% of all patients, either as part of primary chamber angle dysgenesis or secondary to surgery, mostly for removal of congenital cataracts. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/a-0839-9091
Publisher Site
http://dx.doi.org/10.1055/a-0839-9091DOI Listing
June 2019
24 Reads

Factors influencing myopic shift in children after intraocular lens implantation.

Eur J Ophthalmol 2019 Apr 26:1120672119845228. Epub 2019 Apr 26.

Stradin's Clinical University Hospital, Riga, Latvia.

Introduction: Intraocular lenses have always been a controversial topic in pediatric cataract surgery. In the early 1990s in the post-Soviet states of Eastern Europe, intraocular lenses promised an easier full-time correction and amblyopia treatment. Since 1991, ophthalmologists in Latvia have been implanting intraocular lenses in infants. Read More

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http://dx.doi.org/10.1177/1120672119845228DOI Listing
April 2019
9 Reads

Risk of aphakic glaucoma after pars plana-lensectomy with and without removal of the peripheral lens capsule.

Eye (Lond) 2019 09 10;33(9):1472-1477. Epub 2019 Apr 10.

Eye Center, Medical Center, Medical Faculty, University of Freiburg, Freiburg, Germany.

Background: The etiology of aphakic glaucoma is unclear. It has been suggested that remaining lens epithelium releases cytokines transducing trabecular meshwork cells. Therefore, we compared two cohorts of children undergoing lensectomy. Read More

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http://dx.doi.org/10.1038/s41433-019-0435-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7002520PMC
September 2019
6 Reads

Early results of micropulse transscleral cyclophotocoagulation for the treatment of glaucoma.

Eur J Ophthalmol 2020 Jul 2;30(4):700-705. Epub 2019 Apr 2.

Department of Ophthalmology and Visual Science, Yale School of Medicine, New Haven, CT, USA.

Purpose: To describe our clinical experience with the efficacy and safety of micropulse transscleral cyclophotocoagulation as a treatment for glaucoma.

Methods: In this retrospective case series, we reviewed the charts of 95 consecutive patients with various glaucoma subtypes who underwent micropulse transscleral cyclophotocoagulation. Patients were offered micropulse transscleral cyclophotocoagulation if they had perimetric glaucoma refractory to intraocular pressure-lowering topical medications and who were poor candidates for traditional filtering surgery. Read More

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http://dx.doi.org/10.1177/1120672119839303DOI Listing
July 2020
48 Reads

The role of primary intraocular lens implantation in the risk of secondary glaucoma following congenital cataract surgery: A systematic review and meta-analysis.

PLoS One 2019 1;14(4):e0214684. Epub 2019 Apr 1.

Department of Ophthalmology, Xiangya Hospital, Central South University, Changsha, Hunan, China.

Objective: This meta-analysis aims to evaluate the incidence of secondary glaucoma in patients under the age of 2 years who underwent congenital cataract surgery with or without primary intraocular lens (IOL) implantation.

Methods: An electronic literature search was performed in Medline, EMBASE, and Web of Science databases to retrieve studies between January 2011 and November 2018. Patients with congenital cataract who did primary IOL implantation, aphakia, or secondary IOL implantation followed by receiving extraction surgery were included in this study. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0214684PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443152PMC
January 2020
8 Reads

Oculo-Facio-Cardio-Dental Syndrome: A Case Report about a Rare Pathological Condition.

Int J Environ Res Public Health 2019 03 14;16(6). Epub 2019 Mar 14.

Institute of Endodontics, Institute of Integrated Clinical Practice, Institute of Experimental Pathology,Institute for Clinical and Biomedical Research (iCBR), Area of Environment Genetics and Oncobiology(CIMAGO), CNC.IBILI, Faculty of Medicine, University of Coimbra, Avenida Bissaya Barreto,3000-075 Coimbra, Portugal.

(1) Background: Oculo-facio-cardio-dental (OFCD) syndrome is a rare pathological condition with an X-linked dominant trait that only occurs in females; no males are born with OFCD syndrome. This syndrome is characterized by congenital cataracts with secondary glaucoma ocular defects, ventricular and atrial septal defects, or mitral valve prolapses. Facial traits are a long narrow face and a high nasal bridge with a bifid nasal tip. Read More

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http://dx.doi.org/10.3390/ijerph16060928DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6466113PMC
March 2019
7 Reads

Secondary Congenital Glaucoma Associated With Retro-orbital Infantile Hemangioma: A Masquerade Syndrome.

J Glaucoma 2019 06;28(6):e103-e106

University Hospital Nord, Chemin des Bourrely, Marseille, France.

Purpose: The main purpose of this study was to describe a unique case of retro-orbital infantile hemangioma (IH) simulating a congenital glaucoma requiring prompt management with systemic propranolol.

Study Design: This was a case report.

Results: A 2-month-old white female was referred to our department of ophthalmology for progressive, unilateral protrusion of the left eye associated with epiphora. Read More

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http://dx.doi.org/10.1097/IJG.0000000000001227DOI Listing
June 2019
32 Reads

Launching a paradigm for first and redo-surgery in primary congenital glaucoma: institutional experience.

Int J Ophthalmol 2019 18;12(2):226-234. Epub 2019 Feb 18.

Mansoura Ophthalmic Center, Faculty of Medicine, Mansoura University, Mansoura 35516, Egypt.

Aim: To evaluate the outcome of the initial and the redo-surgeries for primary congenital glaucoma (PCG) correlated to its degree of severity.

Methods: A retrospective study involved patients with PCG presented between 2010 and 2018. Medical records were reviewed to assess the degree of the preoperative severity according to the intraocular pressure (IOP), corneal diameter and corneal edema. Read More

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http://dx.doi.org/10.18240/ijo.2019.02.07DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6376225PMC
February 2019
7 Reads

Profile of childhood glaucoma at a tertiary center in South India.

Indian J Ophthalmol 2019 Mar;67(3):358-365

VST Glaucoma Center, L V Prasad Eye Institute, Banjara Hills, Hyderabad, Telangana, India.

Purpose: To describe the prevalence of various types of childhood glaucomas, their clinical features and treatment methods.

Methods: We prospectively included consecutive children with glaucoma presenting to glaucoma clinic for the first time between March 2013 and May 2014. We classified childhood glaucomas as per the classification proposed by Congenital Glaucoma Research Network. Read More

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http://dx.doi.org/10.4103/ijo.IJO_786_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6407385PMC
March 2019
9 Reads

Prevalence of FOXC1 Variants in Individuals With a Suspected Diagnosis of Primary Congenital Glaucoma.

JAMA Ophthalmol 2019 04;137(4):348-355

Department of Ophthalmology, Flinders University, Flinders Medical Centre, Adelaide, Australia.

Importance: Both primary and secondary forms of childhood glaucoma have many distinct causative mechanisms, and in many cases a cause is not immediately clear. The broad phenotypic spectrum of secondary glaucoma, particularly in individuals with variants in FOXC1 or PITX2 genes associated with Axenfeld-Rieger syndrome, makes it more difficult to diagnose patients with milder phenotypes. These cases are occasionally classified and managed as primary congenital glaucoma. Read More

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http://archopht.jamanetwork.com/article.aspx?doi=10.1001/jam
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http://dx.doi.org/10.1001/jamaophthalmol.2018.5646DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6459212PMC
April 2019
35 Reads

Syndromic Multisuture Craniosynostosis With Associated Anterior Segment Dysgenesis, Optic Nerve Hypoplasia, and Congenital Glaucoma.

Cleft Palate Craniofac J 2019 07 25;56(6):823-826. Epub 2018 Dec 25.

1 Division of Plastic Surgery, Baylor College of Medicine, Houston, TX, USA.

Patients with craniosynostosis with subnormal vision due to papilledema and/or exposure-related corneal decompensation are well documented in the literature; however, there is only a single prior documented case of vision compromise secondary to anterior segment dysgenesis and glaucoma in this patient population. This report highlights a case of syndromic craniosynostosis with advanced corneal decompensation and anterior segment dysgenesis that was masked and ultimately delayed the diagnosis of congenital glaucoma. Read More

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http://dx.doi.org/10.1177/1055665618820481DOI Listing
July 2019
11 Reads

Efficacy and safety of vitrectomy for congenital cataract surgery: a systematic review and meta-analysis based on randomized and controlled trials.

Acta Ophthalmol 2019 May 22;97(3):233-239. Epub 2018 Nov 22.

Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Key Laboratory of Ophthalmology and Visual Sciences, Beijing Tongren Hospital of Capital Medical University, Beijing, China.

Purpose: To explore the effectiveness and safety of vitrectomy for congenital cataract surgery.

Methods: We searched PubMed, Science Direct, The Cochrane Library, China National Knowledge Infrastructure and the Wanfang Database. Two researchers extracted data and assessed paper quality independently. Read More

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http://doi.wiley.com/10.1111/aos.13974
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http://dx.doi.org/10.1111/aos.13974DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6587933PMC
May 2019
40 Reads
2.844 Impact Factor

LTBP2-related "Marfan-like" phenotype in two Roma/Gypsy subjects with the LTBP2 homozygous p.R299X variant.

Am J Med Genet A 2019 01 18;179(1):104-112. Epub 2018 Dec 18.

Pediatric Cardiology and Arrhythmology Unit, Department of Pediatric Cardiology and Cardiac Surgery, IRCCS-Bambino Gesù Children Hospital and Research Institute, Rome, Italy.

Recessive variants in LTBP2 are associated with eye-restricted phenotypes including (a) primary congenital glaucoma and (b) microspherophakia/megalocornea and ectopia lentis with/without secondary glaucoma. Nosology of LTBP2 pathology in humans is apparently in contrast with the consolidated evidence of a wide expression of this gene in the developing embryo. Accordingly, in previously published patients with LTBP2-related eye disease, additional extraocular findings have been occasionally reported and include, among others, high-arched palate, tall stature, and variable cardiac involvement. Read More

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http://doi.wiley.com/10.1002/ajmg.a.10
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http://dx.doi.org/10.1002/ajmg.a.10DOI Listing
January 2019
43 Reads

Systemic Associations of Childhood Glaucoma: A Review.

J Pediatr Ophthalmol Strabismus 2018 Nov;55(6):397-402

Purpose: To review systemic associations of childhood glaucoma.

Methods: Patients younger than 15 years and diagnosed as having glaucoma were divided into four groups: isolated primary congenital glaucoma, glaucoma with other congenital ocular anomalies, congenital glaucoma with known systemic diseases, and secondary glaucoma. Prevalence and type of systemic associations in each group were studied. Read More

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https://www.healio.com/doiresolver?doi=10.3928/01913913-2018
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http://dx.doi.org/10.3928/01913913-20180905-01DOI Listing
November 2018
24 Reads
0.731 Impact Factor