481 results match your criteria Glaucoma Secondary Congenital


Congenital aniridia: clinical profile of children seen at the University College Hospital, Ibadan, South-West Nigeria.

Ther Adv Ophthalmol 2021 Jan-Dec;13:25158414211019513. Epub 2021 May 31.

Department of Ophthalmology, College of Medicine, University of Ibadan and University College Hospital, Ibadan, Nigeria.

Purpose: To describe the clinical features of patients younger than 16 years with aniridia presenting to the Paediatric Ophthalmology unit of the Eye Clinic, University College Hospital, Ibadan, Nigeria.

Methods: The is a retrospective review of children with aniridia seen between May 2015 and April 2019 at the Paediatric Ophthalmology unit of the Eye Clinic, University College Hospital in Ibadan. Data on demographic characteristics, presenting complaints, ocular and systemic examination findings, and interventions were collected and descriptively summarised. Read More

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Management of strabismus related to infantile glaucoma: Case series.

Arch Soc Esp Oftalmol (Engl Ed) 2021 Jun 6;96(6):293-298. Epub 2021 Jan 6.

Servicio de Oftalmología, Hospital Clínico San Carlos, Madrid, Spain.

Objective: To evaluate the different modalities of treatment of the strabismus related to infantile glaucoma, its complications, and results.

Methods: The clinical history of 7 patients with infantile glaucoma which required strabismus surgical treatment were analyzed. Age at onset of glaucoma, type of glaucoma, glaucoma surgeries, type of strabismus, strabismus surgical treatment and postoperative results were studied. Read More

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Profile of Glaucoma in the Eastern Region of Saudi Arabia: A Retrospective Study.

Saudi J Med Med Sci 2021 May-Aug;9(2):167-174. Epub 2021 Apr 29.

Department of Ophthalmology, Imam Abdulrahman Bin Faisal University, King Fahd Hospital of the University, Dammam, Saudi Arabia.

Background: Glaucomas remain asymptomatic until severe, indicating that the actual number of affected individuals may be higher than those diagnosed.

Objective: To study the clinical patterns of glaucoma cases in the Eastern Province of Saudi Arabia.

Patients And Methods: This retrospective study was conducted at King Fahd Hospital of the University, Al-Khobar, and Dhahran Eye Specialist Hospital, Dhahran, Saudi Arabia. Read More

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Alcohol and the Eye.

J Ophthalmic Vis Res 2021 Apr-Jun;16(2):260-270. Epub 2021 Apr 29.

Ophthalmic Research Center, Research Institute for Ophthalmology and Vision Science, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

In this article, we present a review of ocular conditions related to alcohol consumption. A search of the literature published from 1952 to March 2020 was performed. The titles and abstracts were screened and the eligible studies were selected. Read More

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Histologic, immunohistochemical, and scanning electron microscopic comparison of pre-iridal monocellular and fibrovascular membranes in normal and glaucomatous canine globes.

Vet Ophthalmol 2021 Apr 27. Epub 2021 Apr 27.

Department of Small Animal Clinical Sciences, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, SK, Canada.

Objectives: (i) To evaluate immunohistochemical labeling of pre-iridal monocellular and fibrovascular membranes and (ii) describe the light and scanning electron microscopic (SEM) characteristics of these membranes in glaucomatous and normal/control canine globes.

Materials And Methods: All globes were evaluated with light microscopy. Immunohistochemical labeling for CD18, Smooth muscle actin (SMA), and CD117 was completed on 40 canine globes with congenital/anterior segment dysgenesis-associated glaucoma (n = 10), primary/goniodysgenesis-associated glaucoma (n = 10), secondary glaucoma (n = 10), and normal/control globes (n = 10). Read More

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Dexamethasone implant migration in an eye with congenital glaucoma: A case report and review of the literature.

Eur J Ophthalmol 2021 Mar 29:11206721211005696. Epub 2021 Mar 29.

Department of Ophthalmology and Visual Sciences, University of Maryland School of Medicine, Baltimore, MD, USA.

Introduction: The dexamethasone (DEX) implant is an FDA approved treatment for diabetic macular edema, non-infectious posterior uveitis, and macular edema secondary to branch or central retinal vein occlusions. We describe a case of anterior chamber (AC) migration of a DEX implant in a patient with a history of congenital glaucoma and perform a review of the literature on this particular complication, summarizing the common risk factors, subsequent complications, and management options.

Case Description: A 46-year-old female with a history of congenital glaucoma, status post cataract extraction with insertion of intraocular lens, pars plana vitrectomy, and Baerveldt tube implant in the left eye was referred for post-operative cystoid macular edema (CME). Read More

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Alveolar capillary dysplasia without misalignment of pulmonary veins, hyperinflammation, megalocornea and overgrowth - Association with a homozygous 2bp-insertion in LTBP2?

Eur J Med Genet 2021 Jun 22;64(6):104209. Epub 2021 Mar 22.

Department of Pediatrics, RWTH Aachen University Hospital, Aachen, Germany.

We present a male infant with alveolar capillary dysplasia without misalignment of pulmonary veins, hyperinflammation, megalocornea and macrosomia/macrocephaly at birth. Whole-exome sequencing revealed a homozygous 2bp-insertion in the latent transforming growth factor-beta binding protein 2 (LTBP2) (c.278_279dup, p. Read More

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Outcomes of Glaucoma Drainage Device Implantation and Trabeculectomy With Mitomycin C in Glaucoma Secondary to Aniridia.

Am J Ophthalmol 2021 Jul 15;227:173-181. Epub 2021 Mar 15.

Bascom Palmer Eye Institute, University of Miami School of Medicine, Miami, Florida, USA.

Purpose: To compare the outcomes of Aurolab aqueous drainage implant (AADI; Aurolab) placement and trabeculectomy with mitomycin C (MMC) in patients with glaucoma secondary to aniridia.

Design: Retrospective comparative interventional case series.

Methods: This study included patients with congenital aniridia who underwent AADI implantation or trabeculectomy with MMC. Read More

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Somatic GNAQ R183Q mutation is located within the sclera and episclera in patients with Sturge-Weber syndrome.

Br J Ophthalmol 2021 Mar 11. Epub 2021 Mar 11.

Department of Ophthalmology, Shanghai 9th People's Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai 200011, China

Aims: To determine the correspondence between GNAQ R183Q (c.548G>A) mutation in abnormal scleral tissue of patients with Sturge-Weber syndrome (SWS) secondary glaucoma and explore the role of GNAQ R183Q in glaucoma pathogenesis.

Methods: Episcleral tissues were obtained from 8 patients: SWS secondary glaucoma (n=5) and primary congenital glaucoma (PCG, n=3). Read More

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Ab Interno Goniotomy Combined with Ab Externo Trabeculotomy in Advanced Primary Congenital Glaucoma Patients: 2-Year Follow-Up.

Authors:
Hazem Helmy

Clin Ophthalmol 2021 15;15:565-574. Epub 2021 Feb 15.

Glaucoma Unit, Glaucoma and Optic Nerve Disease Department, Research Institute of Ophthalmology; RIO, Giza, Egypt.

Introduction: Primary congenital glaucoma (PCG) is a challenging disease that needs to be surgically managed with more innovative methods. Conventional incisional surgery, such as goniotomy and trabeculotomy, has a primary high success rate, but does not seem to be a very effective treatment in advanced stages.

Design: A prospective clinical case study. Read More

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February 2021

Crystalline lens alterations in congenital aniridia.

Arch Soc Esp Oftalmol (Engl Ed) 2021 Feb 18. Epub 2021 Feb 18.

Vissum Innovation, Alicante, España; División de Oftalmología, Universidad Miguel Hernández, Alicante, España. Electronic address:

Congenital aniridia is a rare genetic disease associated with mutations in the PAX6 gene. Changes in the lens in aniridia can be alterations of size and shape, of position - which generally reveal zonular weakness and determines subluxation of the lens - and mainly changes in transparency, cataracts, with variable morphology of polar, cortical, subcapsular, lamellar, and more rarely, nuclear cataract. Visual acuity and quality of vision in patients with congenital aniridia complicated by cataracts can be improved by carefully planned surgery, when lack of media transparency justifies surgical indication. Read More

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February 2021

Paediatric glaucoma in Hong Kong: a multicentre retrospective analysis of epidemiology, presentation, clinical interventions, and outcomes.

Hong Kong Med J 2021 Feb 4;27(1):18-26. Epub 2021 Feb 4.

Hong Kong Eye Hospital, Kowloon Central Cluster, Hospital Authority, Hong Kong.

Purpose: To document the epidemiology, presentation, clinical interventions, and outcomes of paediatric glaucoma in Hong Kong.

Methods: This multicentre territory-wide retrospective study was performed by reviewing charts of patients with paediatric glaucoma in six clusters of the Hong Kong Hospital Authority and The Chinese University of Hong Kong from 2006 to 2015.

Results: This study included 150 eyes of 98 patients with paediatric glaucoma (presenting age: 5. Read More

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February 2021

Clinical characteristics and treatment of secondary glaucoma, glaucoma suspects and ocular hypertension after congenital cataract surgery.

Eur J Ophthalmol 2021 Feb 1:1120672121991356. Epub 2021 Feb 1.

Department of Ophthalmology, Medical University of Vienna, MUV, Vienna, Austria.

Objective: To evaluate changes in intraocular pressure after congenital cataract surgery in a real-world setting.

Methods: This retrospective case series included all children aged 0-2 years undergoing lens extraction due to congenital cataract. Development of an elevated intraocular pressure was divided into three groups: secG, suspG and OHT. Read More

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February 2021

Surgical Outcomes of Microcatheter-assisted Trabeculotomy as a Secondary Procedure in Patients with Primary Congenital Glaucoma.

Middle East Afr J Ophthalmol 2020 Jul-Sep;27(3):145-149. Epub 2020 Oct 30.

Division of Glaucoma, King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia.

Purpose: To investigate the efficacy and safety of illuminated microcatheter-assisted trabeculotomy as a secondary procedure in patients with primary congenital glaucoma (PCG).

Methods: This retrospective case series included patients with PCG who underwent trabeculotomy using an illuminated microcatheter with the intent of catheterizing the full circumference of Schlemm's canal in a single procedure. Success was defined as intraocular pressure (IOP) ≤21 mmHg, with or without the use of glaucoma medications. Read More

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January 2021

The role of clinical examination of the optic nerve head in glaucoma today.

Curr Opin Ophthalmol 2021 Mar;32(2):83-91

Glaucoma Research Facility & Clinical Service, Dr Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute Of Medical Sciences, New Delhi, India.

Purpose Of Review: The study was undertaken to assess the current importance of clinical examination of the optic nerve head (ONH) in glaucoma management.

Recent Findings: ONH changes in glaucoma are easily assessed with good specificity on examination, whereas imaging has not been able to identify pallor of the neuroretinal rim (NRR), disc hemorrhages, or vascular signs of acquired cupping. Glaucomatous neuropathy in primary open angle glaucoma (POAG) has extensive databases on imaging machines, however, other glaucomas such as primary angle closure glaucoma (PACG), juvenile open angle glaucoma (JOAG), congenital, and secondary glaucomas have been reported to have a significantly different ONH morphology. Read More

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First observation of secondary childhood glaucoma in Coffin-Siris syndrome: a case report and literature review.

BMC Ophthalmol 2021 Jan 11;21(1):28. Epub 2021 Jan 11.

Department of Ophthalmology, University Medical Centre of the Johannes Gutenberg University Mainz, Langenbeckstr. 1, D - 55131, Mainz, Germany.

Background: Severe congenital ophthalmological malformations and glaucoma might be an important occasional feature in patients with Coffin-Siris syndrome (CSS), especially Coffin-Siris syndrome 9 (CSS9, OMIM #615866) caused by SOX11 mutation. Recently, primary (open-angle) glaucoma was described in two children with the most common form of Coffin-Siris syndrome, CSS1 (OMIM #135900) by ARID1B (AT-rich interaction domain-containing protein 1B) gene mutation. In this article, we present the first report of glaucoma with Coffin-Siris syndrome 9 as well as the first report of secondary glaucoma with any form of Coffin-Siris syndrome. Read More

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January 2021

Vision-related quality of life in patients with a history of congenital glaucoma.

Eur J Ophthalmol 2020 Dec 21:1120672120977354. Epub 2020 Dec 21.

Eye Research Center, Rassoul Akram Hospital, Iran University of Medical Sciences, Tehran, Iran.

Purpose: To assess the vision-related quality of life in adult patients with a history of primary congenital glaucoma.

Methods: In a cross-sectional hospital-based study eligible patients with a history of primary congenital glaucoma aged more than 18 were recruited in the study. Patients with secondary glaucoma and monocular patients were excluded. Read More

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December 2020

Long-term Efficacy of Mitomycin C Augmented Trabeculectomy in a Mixed Pediatric Glaucoma Cohort.

J Glaucoma 2021 Apr;30(4):357-361

Department of Paediatric Ophthalmology, Birmingham Women's and Children's Hospital, Birmingham.

Precis: This paper reports a retrospective consecutive case series investigating the efficacy of Mitomycin C-augmented trabeculectomy in the treatment of primary and secondary pediatric glaucoma in a mixed etiology, multiethnic cohort of patients.

Purpose: To evaluate the long-term efficacy and safety of Mitomycin C-augmented trabeculectomy in a mixed, tertiary-referral, pediatric glaucoma cohort.

Methods: Retrospective consecutive review of all children (37 eyes) undergoing Mitomycin C-augmented trabeculectomy by a single surgeon between 2008 and 2016. Read More

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Glaucoma-Related Adverse Events at 10 Years in the Infant Aphakia Treatment Study: A Secondary Analysis of a Randomized Clinical Trial.

JAMA Ophthalmol 2021 02;139(2):165-173

Department of Ophthalmology, Stanford University School of Medicine, Palo Alto, California.

Importance: Glaucoma-related adverse events constitute serious complications of cataract removal in infancy, yet long-term data on incidence and visual outcome remain lacking.

Objective: To identify and characterize incident cases of glaucoma and glaucoma-related adverse events (glaucoma + glaucoma suspect) among children in the Infant Aphakia Treatment Study (IATS) by the age of 10.5 years and to determine whether these diagnoses are associated with optic nerve head (ONH) and peripapillary retinal nerve fiber layer (RNFL) assessment. Read More

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February 2021

Lens regeneration in humans: using regenerative potential for tissue repairing.

Ann Transl Med 2020 Nov;8(22):1544

State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China.

The crystalline lens is an important optic element in human eyes. It is transparent and biconvex, refracting light and accommodating to form a clear retinal image. The lens originates from the embryonic ectoderm. Read More

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November 2020

Management of strabismus related to infantile glaucoma: Case series.

Arch Soc Esp Oftalmol 2021 Jun 23;96(6):293-298. Epub 2020 Oct 23.

Servicio de Oftalmología, Hospital Clínico San Carlos, Madrid, España.

Objective: To evaluate the different modalities of treatment of the strabismus related to infantile glaucoma, its complications, and results.

Methods: The clinical history of 7 patients with infantile glaucoma which required strabismus surgical treatment were analyzed. Age at onset of glaucoma, type of glaucoma, glaucoma surgeries, type of strabismus, strabismus surgical treatment and postoperative results were studied. Read More

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An Infectious Cause of Congenital Pupillary-Iris-Lens Membrane With Secondary Angle Closure Glaucoma in an Infant.

J Glaucoma 2021 May;30(5):e271-e273

Departments of Glaucoma.

Purpose: The aim of the study was to report an infectious cause of congenital pupillary-iris-lens membrane with secondary angle closure glaucoma in an infant.

Design: This was a case report.

Methods: Institutional review board exemption for this report was obtained from the Institutional Ethics Committee, Aravind Eye Hospital, Tirunelveli. Read More

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Childhood Glaucoma Profile in a Brazilian Tertiary Care Center Using Childhood Glaucoma Research Network Classification.

J Glaucoma 2021 Feb;30(2):129-133

Department of Ophthalmology and Visual Science, Federal University of São Paulo.

Purpose: To apply the Childhood Glaucoma Research Network (CGRN) classification in children from a pediatric glaucoma outpatient clinic in a tertiary Brazilian care center to better understand the prevalence and the demographic and clinical characteristics of each subtype of childhood glaucoma.

Methods: This was a retrospective study in which medical records were collected from patients assisted in childhood glaucoma's clinic at the Department of Ophthalmology and Visual Sciences, Federal University of São Paulo from January 2010 to January 2018. The initial diagnosis and new diagnosis according to CGRN classification were collected. Read More

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February 2021

Long-term outcomes of the Ahmed glaucoma valve surgery in childhood glaucoma.

J AAPOS 2020 12 15;24(6):346.e1-346.e8. Epub 2020 Oct 15.

Glaucoma Division, King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia. Electronic address:

Purpose: To report the rates of success of Ahmed glaucoma valve (AGV) surgery in early childhood glaucoma and factors associated with success.

Methods: Children with primary congenital or early childhood secondary glaucoma who underwent AGV surgery over a 10-year period (one eye per child) at a single institution were identified. Surgical failure was defined as having one or more of the following: intraocular pressure of >21 mm Hg 3 months postoperatively, reoperation for glaucoma, and vision loss to no light perception. Read More

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December 2020

Clinical Characteristics and Treatment of Secondary Glaucoma After Pediatric Congenital Cataract Surgery in a Tertiary Referral Hospital in Spain.

J Pediatr Ophthalmol Strabismus 2020 Sep;57(5):292-300

Purpose: To analyze clinical characteristics, treatment, and long-term outcomes of pediatric patients with glaucoma after congenital cataract surgery at a single tertiary care hospital.

Methods: Medical records of pediatric patients diagnosed as having glaucoma secondary to congenital cataract surgery between 1996 and 2016 were reviewed retrospectively.

Results: A total of 58 eyes of 42 patients were included with a median follow-up time of 55 months (interquartile range [IQR]: 27 to 128) after glaucoma diagnosis. Read More

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September 2020

Incidence and Risk Factors of Glaucoma Following Pediatric Cataract Surgery With Primary Implantation.

Am J Ophthalmol 2021 04 18;224:1-6. Epub 2020 Sep 18.

Department of Pediatric Ophthalmology, Fondation Ophtalmologique Rothschild, Paris, France. Electronic address:

Purpose: To determine the incidence and risk factors for glaucoma after pediatric cataract surgery with intraocular lens (IOL) implantation.

Design: Retrospective, consecutive case series.

Methods: In this single-center study, we reviewed 136 children (199 eyes) who underwent pediatric cataract surgery before 1 year of age with a minimum of 1 year of follow-up. Read More

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Descemet Membrane Endothelial Keratoplasty in Children.

Cornea 2021 Apr;40(4):453-457

*Department of Ophthalmology, Sorocaba Eye Hospital, Sorocaba Eye Bank, Sorocaba, São Paulo, Brazil; †Department of Ophthalmology, Federal University of São Paulo, São Paulo, Brazil; and ‡Eye Clinic Day Hospital, São Paulo, São Paulo, Brazil.

Purpose: To describe the outcomes of Descemet membrane endothelial keratoplasty (DMEK) performed in amblyopic aged (younger than 8 years) children.

Methods: This is a single-center retrospective study, including 11 eyes (7 congenital hereditary endothelial dystrophy and 4 congenital glaucoma) of 6 children in amblyopic age undergoing DMEK by a single surgeon (N.C. Read More

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Long-term success after trabeculotomy in primary congenital glaucoma - a study with up to 35 years follow-up.

Acta Ophthalmol 2020 Sep 10. Epub 2020 Sep 10.

Department of Ophthalmology, University Hospital of Copenhagen, Rigshospitalet-Glostrup, Glostrup, Denmark.

Purpose: To evaluate the surgical success after trabeculotomy for primary congenital glaucoma (PCG) in Denmark in the last 40 years.

Methods: Retrospective review of medical files on children who all underwent trabeculotomy as the first surgical intervention between January 1rst, 1977 and December 31, 2016. Information on diagnosis and surgical procedures were extracted. Read More

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September 2020

Glycerin-preserved Human-donor Corneoscleral Patch Grafts for Glaucoma Drainage Devices.

J Glaucoma 2020 11;29(11):1065-1069

Department of Ophthalmology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.

Precis: Glycerin-preserved, human-donor, corneoscleral patch grafts are effective and safe for glaucoma drainage device (GDD) implantation, and they are comparable to previously reported materials. It can be preserved with the sterile technique for up to 12 months.

Purpose: To evaluate the efficacy and safety of glycerin-preserved human donor corneoscleral tissue as the patch graft for GDD implantation. Read More

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November 2020