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Vestn Oftalmol 2018 ;134(5. Vyp. 2):244-249

Research Institute of Eye Diseases, 11A Rossolimo St., Moscow, Russian Federation, 119021.

The XEN-45 drainage implant is a hypotensive device made of hydrophilic gelatin and stabilized by glutaraldehyde. The implant is designed for modern Microinvasive Glaucoma Surgery (MIGS). Being installed ab interno, the stent drains aqueous fluid from the anterior chamber into the subconjunctival space. Read More

Curr Opin Ophthalmol 2019 Jan;30(1):56-62

Private Practice, Gdańsk, Poland.

Purpose Of Review: The aim of this review was to assess the risk factors and course of postoperative intraocular pressure (IOP) increase in order to determine the optimal the treatment.

Recent Findings: Early postoperative IOP elevation following cataract surgery is a frequent adverse event, and might represent 88% early postoperative complications. The risk factors for IOP elevation following phacoemulsification cataract surgery include residual viscoelastic material, resident performed surgery, glaucoma, pseudoexfoliation syndrome, axial length over 25 mm, tamsulosin intake, topical steroid application in steroid responders. Read More

Graefes Arch Clin Exp Ophthalmol 2018 Nov 28. Epub 2018 Nov 28.

Department of Ophthalmology, University of Patras, Medical School, 265 04, Patras, Greece.

Purpose: To evaluate the effectiveness of a single session of micropulse laser trabeculoplasty (MLT) to lower intraocular pressure (IOP) in patients with pseudoexfoliation glaucoma (PEXG).

Methods: In this single-center, one-arm, prospective study patients with PEXG under prostaglandine analogue monotherapy with inadequate IOP control were treated with 360° 532-nm MLT. Patients were evaluated at 1 day, 1 month, 3 months, 6 months, and 12 months post-MLT while they were treated with the same drug regimen as pre-MLT. Read More

Endocr Metab Immune Disord Drug Targets 2018 Nov 27. Epub 2018 Nov 27.

İnönü Univeristy Turgut Özal Medical Center - Biostatistics Malatya. Turkey.

Objective: To investigate whether serum vitamin D levels have an effect on pseudoexfolation (PEX) glaucoma/syndrome development and on the control of glaucoma in these cases.

Method: A total of 31 cases with PEX glaucoma, 34 cases with the PEX syndrome and 43 control subjects of similar age and sex were included in the study. Vitamin D levels were compared between the groups and also between the cases where glaucoma surgery was performed or not. Read More

Ocul Immunol Inflamm 2018 Nov 13:1-5. Epub 2018 Nov 13.

b Meram School of Medicine, Department of Ophthalmology , Necmettin Erbakan University , Konya , Turkey.

Purpose: To evaluate the association between monocyte count/high-density lipoprotein (HDL) ratio (MHR) and lymphocyte count/monocyte count ratio (LMR) with pseudoexfoliation syndrome (PEXS) and pseudoexfoliation glaucoma (PEXG).

Materials And Methods: A total of 63 participants included in the study. Participants were divided into three groups. Read More

Asia Pac J Ophthalmol (Phila) 2018 Nov 13. Epub 2018 Nov 13.

Einhorn Clinical Research Center, New York Eye and Ear Infirmary of Mount Sinai, New York, NY.

The first description of exfoliation syndrome (XFS) was presented by John Gustaf Lindberg in his doctoral thesis 100 years ago. The syndrome is an age-related disorder in which abnormal fibrillar extracellular material is produced and accumulates in several ocular tissues. Once thought to be peculiar to Scandinavia, XFS is found in almost every race and ethnic group. Read More

Turk J Ophthalmol 2018 Oct 31;48(5):215-220. Epub 2018 Oct 31.

Eskisehir Osmangazi University Faculty of Medicine, Department of Biostatistics, Eskişehir, Turkey.

Objectives: To investigate the three single nucleotide polymorphisms (SNPs) (rs3825942, rs1048661, and rs2165241) of the gene in pseudoexfoliation syndrome (XFS) and pseudoexfoliation glucoma (XFG) in the Turkish population.

Materials And Methods: DNA was obtained from blood samples of 48 XFS, 58 XFG, and 171 control subjects. Three SNPs (rs3825942, rs1048661, rs2165241) were investigated with real time PCR, a probe-based genotyping method, and melting curve analysis. Read More

Invest Ophthalmol Vis Sci 2018 Nov;59(13):5355-5365

Hamilton Glaucoma Center, Shiley Eye Institute, Department of Ophthalmology, University of California, San Diego, California, United States.

Purpose: To better understand the relationship of lamina cribrosa (LC) and choroid features to the severity of pseudoexfoliation glaucoma (PXG).

Methods: In this cross-sectional study, 137 eyes of 122 subjects (47 eyes with moderate/advanced PXG [mean deviation (MD), -15.0 ± 7. Read More

Ophthalmologica 2018 Nov 2:1-7. Epub 2018 Nov 2.

Department of Ophthalmology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.

Purpose: The aim of this study was to evaluate pseudoexfoliation (PXF) as an independent risk factor for the occurrence of retinal vein occlusion (RVO).

Methods: This is a retrospective cohort study on the records of 300 PXF glaucoma patients (PXF group), 300 non-PXF glaucoma patients, and 599 nonglaucoma non-PXF (nGnP group) patients.

Results: Multivariate analysis resulted in a significant probability for RVO in the PXF (p = 0. Read More

Ophthalmology 2018 Oct 17. Epub 2018 Oct 17.

Glaucoma Services, Wilmer Eye Institute, Baltimore, Maryland; Department of Ophthalmology, University of Michigan, Ann Arbor, Michigan.

Purpose: To compare intraoperative complication rates, 1-year visual outcomes, and postoperative complication rates over the first postoperative year in eyes with and without pseudoexfoliation undergoing cataract surgery.

Design: Prospective, comparative, interventional study.

Participants: Nine hundred thirty eyes with cataract and uncomplicated pseudoexfoliation (without phacodonesis, clinically shallow anterior chambers, or pupil size <4 mm) and 476 controls with cataract but without pseudoexfoliation recruited from 4 centers of the Aravind Eye Care System in Southern India. Read More

J Glaucoma 2018 Oct 18. Epub 2018 Oct 18.

Gazi University School of Medicine Department of Ophthalmology, Ankara, Turkey.

Purpose: The purpose of the present study was to evaluate the aqueous humor Endocan and Endostatin levels in patients with pseudoexfoliation syndrome (PEX) and to compare the results with healthy individuals.

Methods: 29 cataract patients with PEX syndrome (PEX group) and 32 cataract patients without PEX syndrome (control group) were enrolled in the study. Endocan and Endostatin were measured in the aqueous humor of the PEX and control groups by enzyme-linked immunosorbent assay. Read More

Eur J Ophthalmol 2018 Oct 14:1120672118805882. Epub 2018 Oct 14.

1 Department of Ophthalmology, Hospital Universitario Ramón y Cajal, Madrid, Spain.

Purpose: To compare peripapillary vascular parameters derived from two optical coherence tomography angiography devices in pseudoexfoliation glaucoma, primary open-angle glaucoma, and healthy controls and to evaluate their diagnostic accuracy.

Methods: Observational, cross-sectional study. In total, 20 eyes with pseudoexfoliation glaucoma, 20 primary open-angle glaucoma eyes matched by peripapillary retinal nerve fiber layer thickness, and 20 control eyes were recruited. Read More

J Glaucoma 2018 Oct 11. Epub 2018 Oct 11.

Department of Ophthalmology, Semmelweis University, 1085. Budapest, Mária u. 39. Hungary.

Acta Ophthalmol 2018 Oct 8. Epub 2018 Oct 8.

Vitreoretinal Surgery Unit, Department of Ophthalmology, Helsinki University Hospital, Helsinki, Finland.

Purpose: To examine the clinical outcomes of intraocular lens (IOL) scleral fixation with the friction knot technique.

Methods: Retrospective case series of 152 eyes of 152 patients with inadequate capsular bag support operated with the friction knot IOL scleral fixation technique by a single surgeon. The fixated IOLs were one-piece or three-piece models all with open loop haptics. Read More

Arch Soc Esp Oftalmol 2018 Dec 2;93(12):573-579. Epub 2018 Oct 2.

Grippo Glaucoma Center, Buenos Aires, Argentina; Universidad de Yale, New Haven, CT, Estados Unidos; Hospital Alemán, Buenos Aires, Argentina. Electronic address:

Objective: To report the results using Micropulse transscleral cyclophotocoagulation (Iridex) in the treatment of glaucoma.

Methods: Retrospective study in adult patients with glaucoma with at least 6 months of follow-up, and only one session of Micropulse. The same surgical technique was used in all cases. Read More

PLoS One 2018 3;13(10):e0204263. Epub 2018 Oct 3.

Beijing Institute of Ophthalmology, Beijing Key Laboratory of Ophthalmology and Visual Sciences, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University; Beijing, China.

Purpose: Systemic inflammation is potentially associated with ocular diseases such as late age-related macular degeneration (AMD). Using the serum concentration of high-sensitive C-reactive protein (hs-CRP) as surrogate of systemic inflammation, we examined potential associations between the serum hs-CRP concentration and the presence and degree of eye diseases.

Methods: The population-based Beijing Eye Study included 3468 Chinese individuals. Read More

Ophthalmology 2018 Sep 29. Epub 2018 Sep 29.

Department of Ophthalmology, Western University, Ontario, Canada. Electronic address:

Purpose: The effectiveness of selective laser trabeculoplasty (SLT) was compared with argon laser trabeculoplasty (ALT) in a randomized clinical trial for patients with medically uncontrolled open-angle glaucoma who have previously received 360° SLT.

Design: An active equivalence parallel armed randomized control trial.

Participants: Patients with open-angle glaucoma including pigmentary dispersion syndrome and pseudoexfoliation syndrome were enrolled into the study from 7 different sites across Canada. Read More

Sci Rep 2018 Sep 28;8(1):14533. Epub 2018 Sep 28.

Tottori University, Division of Ophthalmology and Visual Science, Faculty of Medicine, 36-1 Nishi-cho, Yonago, Tottori, 683-8504, Japan.

Glaucoma is a leading cause of blindness worldwide. Purpose of this study was to identify molecular markers that were significantly correlated with presence of glaucoma and outcome of glaucoma surgery. To accomplish this, we determined the profiles of pro-inflammatory cytokines in the aqueous humor of 101 glaucoma patients; 31 primary open angle glaucoma (POAG), 38 pseudoexfoliation glaucoma (PEG), and 32 neovascular glaucoma (NVG). Read More

J Trace Elem Med Biol 2018 Dec 19;50:67-72. Epub 2018 Jun 19.

Schwabachanlage 6, 91054 Erlangen, Germany. Electronic address:

Purpose: Selenium supplementation was seen to be linked to glaucoma disease in a previous study (Lillico A. JE, Reid M et al. (2002) Selenium Supplementation and Risk of Glaucoma in the NPC trial University of Arizona, Tucson, AZ. Read More

Br J Ophthalmol 2018 Sep 24. Epub 2018 Sep 24.

RS Mehta Jain Department of Biochemistry and Cell Biology, KBIRVO block, Vision Research Foundation, Sankara Nethralaya, Chennai, Tamil Nadu, India

Background: Pseudoexfoliation syndrome (PXF) is an idiopathic, elastogenesis-associated systemic disease characterised by amyloid-like material aggregates in the eye. Elevated plasma and aqueous humour (aqH) homocysteine (Hcy) is reportedly associated with PXF. This study is aimed to probe Hcy-mediated alterations in elastin expression. Read More

Acta Ophthalmol 2018 Sep 20. Epub 2018 Sep 20.

Departments of Neuroscience, Ophthalmology, and Surgical Sciences, Uppsala University, Uppsala, Sweden.

Purpose: To study the relationship between pseudoexfoliation (PEX) and aortic aneurysm in a population with a high prevalence of PEX.

Methods: Survival analyses were performed in a cohort of 735 residents aged 65-74 years, examined in a population survey in the municipality of Tierp, Sweden, 1984-1986. To expand the sample size, 1040 people were recruited by means of glaucoma case records established at the Eye Department in Tierp in 1978-2007. Read More

Arq Bras Oftalmol 2018 Sep-Oct;81(5):437-439

Department of Ophthalmology, Universidade Federal de São Paulo, São Paulo, SP, Brazil.

A 89-year-old Black female with a 6-year history of advanced open-angle glaucoma was referred to the Glaucoma Service of the Ophthalmology Department - Federal University of São Paulo (UNIFESP). Best-corrected visual acuity was 20/400 in the right eye and 20/60 in the left eye. Pseudoexfoliation material was observed at the iris border, angle, and the anterior lens surface. Read More

Eur J Ophthalmol 2018 Sep 12:1120672118799622. Epub 2018 Sep 12.

1 Helsinki Retina Research Group, University of Helsinki, Helsinki, Finland.

Background: The purpose of the study was to identify macular edema after cataract surgery in eyes with and without pseudoexfoliation syndrome. The study was a post-hoc analysis of a randomized, double-blind, prospective single-center study. Patients were enrolled between January 2016 and October 2016 as per the national guidelines for the management of cataract in the Department of Ophthalmology, Kymenlaakso Central Hospital, Kotka, Finland. Read More

Pan Afr Med J 2018 18;30:47. Epub 2018 May 18.

Faculté de Médecine et de Pharmacie de Fès CHU Hassan II, Fes, Maroc.

We here report the case of a 79-year old patient who underwent cataract by phacoemulsification associated with preoperative left and right eyes pseudo-capsular exfoliation in 2000. He had pseudo-exfoliative glaucoma with recurrence on the implant. Read More

Eur J Ophthalmol 2018 Sep 6:1120672118795405. Epub 2018 Sep 6.

1 Advanced Eye Centre, PGIMER, Chandigarh, Chandigarh, India.

Introduction: Pseudoexfoliation syndrome is commonly associated with pseudoexfoliation glaucoma. The two nonsynonymous single-nucleotide polymorphisms rs1048661 (R141L) and rs3825942 (G153D) within exon 1 of LOXL1 gene have been found to confer risk of pseudoexfoliation syndrome and pseudoexfoliation glaucoma in different geographical populations. This study aims to find association between two nonsynonymous single-nucleotide polymorphisms with pseudoexfoliation syndrome and pseudoexfoliation glaucoma in North Indian population. Read More

Acta Ophthalmol 2018 Nov 4;96(7):e859-e864. Epub 2018 Sep 4.

1st Department of Ophthalmology, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece.

Purpose: To assess the overdiagnosis of open-angle glaucoma (OAG) and to investigate associated factors.

Methods: This was a cross-sectional, population-based study of an urban Caucasian population in northern Greece. Randomly selected subjects ≥60 years (n = 2554) participated in the Thessaloniki Eye Study. Read More

Ophthalmic Genet 2018 Oct 27;39(5):603-609. Epub 2018 Aug 27.

b Laboratory of Research and Clinical Applications in Ophthalmology, 1st Department of Ophthalmology , School of Medicine, Aristotle University of Thessaloniki, AHEPA Hospital , Thessaloniki , Greece.

Background: Pseudoexfoliation syndrome (PEX) and glaucoma (pseudoexfoliative glaucoma; PEXG, primary open-angle glaucoma; POAG) have mainly been studied for their associations with genes' polymorphisms. The purpose of this exploratory study was to investigate the role of polymorphisms in genes encoding for micro RNAs (miRNAs) and in genes related to miRNA biogenesis.

Material And Methods: In the present genetic association study, ninety-two polymorphisms were investigated for their contribution to PEX (n = 203), PEXG (n = 38), and POAG (n = 40) pathogenesis compared to a control group (n = 188). Read More

Eur J Ophthalmol 2018 Aug 27:1120672118795063. Epub 2018 Aug 27.

Department of Ophthalmology, San Pedro Hospital, Logroño, Spain.

Purpose: To evaluate the intraocular pressure-lowering effect, the safety profile, and the success rate of the XEN45 Gel Stent (Allergan, Dublin, Ireland) in patients with pseudoexfoliative glaucoma.

Methods: Retrospective study conducted on patients with pseudoexfoliative glaucoma, with or without cataract, who underwent XEN45 implantation surgery with subconjunctival mitomycin-C and had a minimum postoperative follow-up period of 12 months. The primary outcome measure was intraocular pressure reduction at 1 year as compared to baseline. Read More

J Glaucoma 2018 Nov;27(11):1009-1016

Department of Ophthalmology, Korea University College of Medicine, Seoul, Korea.

Purpose: The aim of this study was to compare the peripapillary vessel density between eyes with pseudoexfoliation glaucoma (PXG) and eyes with primary open-angle glaucoma (POAG).

Methods: Peripapillary vessel density in the radial peripapillary capillaries was assessed using optical coherence tomography angiography, and compared between patients with PXG and those with POAG, matched for age and mean deviation (MD) of standard automated perimetry. The vessel density was measured between the optic disc margin and 750 μm from the optic disc margin. Read More

J Glaucoma 2018 Nov;27(11):976-980

Department of Clinical Sciences in Malmö, Ophthalmology, Lund University, Malmö.

Purpose: The purpose of this study was to assess the intraocular pressure (IOP) - reducing effect of latanoprost in treatment-naïve patients with newly detected open-angle glaucoma with no restriction of the level of untreated IOP.

Methods: Eighty-six patients (105 eyes) with a diagnosis of open-angle glaucoma received IOP-lowering therapy with latanoprost. The IOP reduction 1 and 3 months after initiation of treatment was recorded. Read More

Lasers Med Sci 2018 Aug 13. Epub 2018 Aug 13.

Faculty of Medicine, AL-Azhar University, Cairo, Egypt.

Aim: The purpose of this study is to identify the effect of Nd: YAG laser posterior capsulotomy using an anterior chamber morphology.

Methods: This study included 42 eyes of 33 pseudophakic patients with visually significant PCO after uncomplicated cataract surgery. Exclusion criteria were complications related to cataract surgery, corneal pathology, pseudoexfoliation, glaucoma, uveitis, previous ocular surgery or trauma, and posterior segment pathology. Read More

Br J Ophthalmol 2018 Nov 12;102(11):1477-1482. Epub 2018 Aug 12.

Allen Foster Community Eye Health Research Centre, Gullapalli Pratibha Rao International Centre for Advancement of Rural Eye Care, L V Prasad Eye Institute, Hyderabad, India.

Aim: To evaluate glaucoma-associated mortality in a rural cohort in India.

Methods: The study cohort comprised individuals aged 40 years and above who took part in the Andhra Pradesh Eye Disease Study (APEDS1) during 1996-2000. All participants underwent detailed comprehensive eye examination. Read More

Clin Ophthalmol 2018 2;12:1199-1204. Epub 2018 Jul 2.

Department of Ophthalmology, University Hospital of Alexandroupolis, Alexandroupolis, Greece,

Background: Endothelin-1 (ET-1) is the most potent vasoconstrictor in the body. There are reports in the literature correlating plasma levels of ET-1 and its impact on retrobulbar hemodynamics. This study evaluates aqueous humor levels of ET-1 and retrobulbar hemodynamics in patients with exfoliation syndrome (XFS) and exfoliation glaucoma (XFG). Read More

Turk J Ophthalmol 2018 Jun 28;48(3):109-114. Epub 2018 Jun 28.

Kemalpaşa State Hospital, Ophthalmology Clinic, İzmir, Turkey.

Objectives: To analyze optic nerve head images of pseudoexfoliative glaucoma (PXG) patients and healthy volunteers obtained with enhanced depth imaging spectral domain-optical coherence tomography (SD-OCT).

Materials And Methods: Seventy patients with PXG and 68 age- and gender-matched healthy subjects were included in this prospective study. The prelaminar tissue and lamina cribrosa were imaged using spectralis OCT with the enhanced depth imaging technique. Read More

J Glaucoma 2018 Jul;27 Suppl 1:S111-S113

Institute of Ophthalmology, Mater Misericordiae University Hospital, Dublin, Ireland.

In this review, we present an update on biomarkers (both clinical and laboratory) on the basis of recent peer-reviewed publications relating to pseudoexfoliation syndrome and pseudoexfoliation glaucoma. Read More

Vestn Oftalmol 2018 ;134(3):28-34

National Ophthalmology Center named after Zarifa Aliyeva, 32/15 Javadhan St., Baku, Azerbaijan, 1114.

Purpose: To assess the safety and efficacy of phaco-canaloplasty in patients with concomitant advanced pseudoexfoliation glaucoma and cataract.

Material And Methods: The study included 56 patients (57 eyes) who underwent phacoanaloplasty guided by Glaucolight microcatheter. All patients were followed up for 48 months. Read More

Int Ophthalmol 2018 Jun 26. Epub 2018 Jun 26.

Department of Ophthalmology, Medical Academy, Lithuanian University of Health Sciences, Mickevičiaus g. 9, 44307, Kaunas, Lithuania.

Purpose: To report a series of cases and microsurgical management of rarely occurring uveitis-glaucoma-hyphema (UGH) syndrome in patients with single-piece acrylic intraocular lens (IOL) placed in the capsular bag.

Methods: It was a series of patients with UGH syndrome induced by posterior chamber IOL/capsular bag complex instability (pseudophakodonesis), who underwent IOL fixation to the iris. Visual acuity, intraocular pressure, number of glaucoma medications and IOL status (position) were recorded by the same protocol before and 6 months after the surgical treatment. Read More

Am J Ophthalmol Case Rep 2018 Sep 22;11:64-65. Epub 2018 May 22.

Icahn School of Medicine at Mount Sinai/New York Eye & Ear, Eye and Vision Research Institute, Department of Ophthalmology, 1468 Madison Avenue, Annenberg 22-86, New York, NY 10029, United States.

To report a case of recurrent hypotony and choroidal effusion following trabeculectomy.

Observations: A 70 year old male with advanced pseudoexfoliation glaucoma in both eyes underwent trabeculectomy in the left eye. Initially intraocular pressure (IOP) was controlled without topical therapy, but dorzolamide-timolol and brimonidine were added when IOP elevated above target. Read More

J Ophthalmol 2018 15;2018:3843098. Epub 2018 May 15.

Private Practice, Privatklinik der Kreuzschwestern Graz, Kreuzgasse 35, 8010-Graz, Austria.

Purpose: The purpose of this prospective analysis was to evaluate the patient and surgeon satisfaction levels after using a fully preloaded acrylic, hydrophobic, monofocal "premium" IOL in pseudoexfoliation syndrome.

Materials And Methods: 42 eyes of twenty-eight patients with progressed cataract formation and pseudoexfoliation syndrome (PXF) or pseudoexfoliation glaucoma and best corrected distance visual acuity (BCDVA) between 0.30-1. Read More

Int J Ophthalmol 2018 18;11(5):823-827. Epub 2018 May 18.

Ulucanlar Eye Research Hospital, Ankara 06250, Turkey.

Aim: To investigate the levels of ghrelin (Gh), acylated ghrelin (AGh) and AGh/Gh ratio in the humor aqueous (HA) of cases with pseudoexfoliation syndrome (PXS), pseudoexfoliation glaucoma (PXG), primary open angle glaucoma (POAG) and to compare these with control subjects.

Methods: A prospective examination was made of the total Gh, and AGh levels in HA of 67 patients undergoing cataract surgery. Patients were divided into 4 groups. Read More

Arq Bras Oftalmol 2018 Apr;81(2):110-115

Ankara Ulucanlar Eye Training and Research Hospital, Ankara, Turkey.

Purpose: To compare the anterior segment parameters of patients with pseudoexfoliation syndrome, patients with pseudoexfoliation glaucoma, and normal subjects.

Methods: This prospective, controlled, comparative study included 150 eyes of 150 patients. The patients were divided into the pseudoexfoliation syndrome group, the pseudoexfoliation glaucoma group, and the control group (50 patients in each group). Read More

Int Ophthalmol 2018 Apr 25. Epub 2018 Apr 25.

University of Health Sciences, Ulucanlar Eye Education and Research Hospital, Ulucanlar caddesi No:59, 06240, Altindag, Ankara, Turkey.

Purpose: To investigate the outcomes of trabeculectomy with 5-fluorouracil (5-FU) with or without subconjunctival bevacizumab in the surgical management of pseudoexfoliation glaucoma (PXG).

Methods: This retrospective study consisted of 49 cases with PXG who underwent initial trabeculectomy with 5-FU. The cases were divided into two age- and sex-matched groups. Read More

Adv Ther 2018 May 11;35(5):619-630. Epub 2018 Apr 11.

Department of Ophthalmology, Hospital Universitario "Principe de Asturias," Universidad de Alcalá, Alcalá de Henares, Spain.

In the last decade, selective laser trabeculoplasty (SLT) has been commonly used in the management of several different types of glaucoma, as either primary or adjunct therapy. The technique has an excellent safety profile and is at least as effective as argon laser trabeculoplasty. Although the actual mechanism of action of SLT remains unclear, evidence has shown that it does not induce morphologically evident trabecular meshwork alterations. Read More

J Cataract Refract Surg 2018 Mar 28;44(3):348-354. Epub 2018 Mar 28.

From the Department of Ophthalmology (Manoharan, Patnaik, Bonnell, SooHoo, Pantcheva, Kahook, Wagner, Lynch, Seibold), University of Colorado School of Medicine and the Department of Biostatistics and Informatics (Wagner), University of Colorado School of Public Health, Aurora, Colorado, USA. Electronic address:

Purpose: To evaluate refractive outcomes after phacoemulsification cataract surgery in patients with glaucoma.

Setting: University of Colorado Health Eye Center, Aurora, Colorado, USA.

Design: Retrospective case series. Read More

Eur J Ophthalmol 2018 Nov 29;28(6):735-740. Epub 2018 Mar 29.

Department of Ophthalmology, Charité-Universitätsmedizin Berlin, Berlin, Germany.

Purpose:: The aim of this study is to assess the intraocular pressure lowering effect and the performance of the glaucoma therapy of the iStent inject in glaucoma patients with uncontrolled intraocular pressure after failed trabeculectomy.

Methods:: In this retrospective study, iStent inject implantation (Glaukos Corporation, Laguna Hills, CA, USA) was performed in 22 eyes of 21 subjects suffering from glaucoma (n = 18 primary open angle glaucoma, n = 3 pseudoexfoliation glaucoma, and n = 1 for secondary glaucoma) with an intraocular pressure above target pressure after failed trabeculectomy (mean = 9.6 ± 8. Read More

J Glaucoma 2018 Jun;27(6):552-557

Ankara Ulucanlar Eye Training and Research Hospital, Ankara, Turkey.

Purpose: The purpose of this study was to perform a comparison of static and dynamic pupillometry measurements in patients with clinically unilateral pseudoexfoliation syndrome (PES) and age-matched controls.

Methods: This prospective cross-sectional study consisted of 38 patients with unilateral PES and 40 control participants. A quantitative pupillometry system was used to evaluate the pupil characteristics of eyes with PES (group 1), clinically unaffected fellow eyes (group 2), and healthy eyes (group 3). Read More

Sci Rep 2018 Mar 19;8(1):4816. Epub 2018 Mar 19.

Beijing Institute of Ophthalmology and Beijing Ophthalmology and Visual Science Key Lab, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China.

To examine associations between cognitive function and ophthalmological parameters, the population-based Beijing Eye Study examined ophthalmologically and physically 3127 individuals (mean age: 64.2 ± 9.8 years). Read More

Int Ophthalmol 2018 Mar 17. Epub 2018 Mar 17.

Department of Ophthalmology, Military Institute of Aviation Medicine, Krasińskiego 54/56, 01-755, Warsaw, Poland.

Purpose: To evaluate the incidence of and factors associated with intraoperative floppy iris syndrome (IFIS) in patients undergoing cataract phacoemulsification.

Methods: In total, 319 eyes of 319 patients who underwent phacoemulsification with implantation of an intraocular lens (IOL) into the posterior chamber were included in this study. Direct injection of epinephrine into the anterior chamber was performed in all cases. Read More

Rom J Ophthalmol 2017 Jul-Sep;61(3):196-201

Department of Ophthalmology, JSS Hospital, Mysore, India.

To study the outcome of cataract surgery in eyes with pseudoexfoliation without signs of glaucoma. This prospective study was done over nine months on patients with pseudoexfoliation undergoing small incision cataract surgery. Only patients with normal intraocular pressure (Central Corneal Thickness Corrected), normal cup disc ratio and open angles were included. Read More

Klin Monbl Augenheilkd 2018 Feb 15;235(2):163-174. Epub 2018 Feb 15.

Universitätsklinikum Erlangen, Augenklinik, Erlangen.

Endothelial dysfunction and vascular dysregulation play a role in the multifactorial pathogenesis of glaucomatous optic nerve atrophy. Hyperhomocysteinemia is a risk factor for endothelial dysfunction and is associated with primary open-angle glaucoma as well as secondary open-angle glaucoma in the pseudoexfoliation syndrome. This paper reviews the literature on the association between homocysteine metabolism and glaucomatous disease and explains the possible role of hyperhomocysteinemia in the pathogenesis and progression of glaucoma. Read More