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Hum Mol Genet 2019 Apr 15. Epub 2019 Apr 15.

Department of Ophthalmology, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.

LOXL1 (lysyl oxidase-like 1) has been identified as the major effect locus in pseudoexfoliation (PEX) syndrome, a fibrotic disorder of the extracellular matrix and frequent cause of chronic open-angle glaucoma. However, all known PEX-associated common variants show allele effect reversal in populations of different ancestry, casting doubt on their biological significance. Based on extensive LOXL1 deep sequencing, we report here the identification of a common noncoding sequence variant, rs7173049A>G, located downstream of LOXL1, consistently associated with a decrease in PEX risk (OR=0. Read More

Curr Eye Res 2019 Apr 9. Epub 2019 Apr 9.

a University of Health Sciences , Beyoglu Eye Training and Research Hospital , Istanbul , Turkey.

Purpose/Aim of the study: The aim of this study was to compare the lamina cribrosa (LC) measurements obtained by Spectral-Domain Optical Coherence Tomography (SD-OCT) and Swept-Source Optical Coherence Tomography (SS-OCT) in the same eye and we also investigate how the differences in measurement will change in the presence of pseudoexfoliation glaucoma (PEG).

Materials And Methods: A total of 30 patients from one institution have accepted. Detailed medical case histories and clinical examination, optic nerve head imaging using the SD-OCT (Heidelberg Engineering, Heidelberg, Germany) and SS-OCT(Triton; Topcon Medical Systems, Tokyo, Japan) for patients with pseudoexfoliation glaucoma and healthy volunteer. Read More

Am J Ophthalmol 2019 Mar 19. Epub 2019 Mar 19.

Hayashi Eye Hospital, Fukuoka, Japan.

Purpose: To compare the effects of a topical intraocular pressure (IOP)-lowering medication for preventing an IOP increase after cataract surgery in eyes with glaucoma.

Design: Randomized clinical study.

Methods: One hundred sixty-five eyes of 165 patients with primary open-angle glaucoma or pseudoexfoliation glaucoma scheduled for phacoemulsification were randomly assigned to one of three groups to receive each medication immediately postoperatively: 1) prostaglandin F2α analogue (travoprost), 2) β-blocker (timolol maleate), or 3) carbonic anhydrase inhibitor (brinzolamide). Read More

Clin Ophthalmol 2019 1;13:453-464. Epub 2019 Mar 1.

Ophthalmology Department, Ulucanlar Eye Training and Research Hospital, University of Health Sciences, Ankara, Turkey.

Pseudoexfoliation syndrome (PES) is a complex and age-related systemic disorder characterized by the progressive accumulation and granular deposition of pseudoexfoliative material in various intraocular and extraocular tissues. The diagnosis of PES is so important because it is a major risk factor for complications during cataract surgery and the most frequent cause of secondary glaucoma. In addition to ocular complications, PES is related with numerous systemic abnormalities, for which the list is growing steadily. Read More

Am J Ophthalmol 2019 Mar 5. Epub 2019 Mar 5.

Department of Ophthalmology, Medical Faculty Mannheim of the Ruprecht-Karls-University of Heidelberg, Mannheim, Germany.

Purpose: To assess the normal distribution of intraocular pressure (IOP) and its associations with ocular, medical, and socioeconomic factors in a Russian population.

Design: Population-based cross-sectional study METHODS: The Ural Eye and Medical Study conducted in a rural and urban area in Ufa/Bashkortostan included 5,899 (80.5%) participants out of 7328 eligible individuals aged 40+ years. Read More

Turk J Ophthalmol 2019 Feb;49(1):1-5

Eskişehir Osmangazi University Faculty of Medicine, Department of Ophthalmology, Eskişehir, Turkey

Objectives: To investigate the relationship between pseudoexfoliation syndrome (PES) and the use of antidepressant medications.

Materials And Methods: This population-based, cross-sectional study included 2,017 of 2,356 invited subjects who were randomly selected from the Turkish Statistical Institute database (www.turksat. Read More

Eur J Ophthalmol 2019 Feb 26:1120672119831532. Epub 2019 Feb 26.

1 Clinic for Eye Diseases, Clinical Center of Serbia, Belgrade, Serbia.

Purpose:: To evaluate the clinical characteristics of newly diagnosed pseudoexfoliative glaucoma and compare them with those pertaining to newly diagnosed primary open-angle glaucoma as well as pseudoexfoliation syndrome.

Methods:: This case-control study involved 306 participants, including patients with newly diagnosed pseudoexfoliative glaucoma, age- and sex-matched normal controls, patients with newly diagnosed primary open-angle glaucoma, and subjects with pseudoexfoliation syndrome. The study was conducted at the Glaucoma Department of Clinic for Eye Diseases, Clinical Center of Serbia, as the referral center for glaucoma in Serbia. Read More

J Glaucoma 2019 Feb 21. Epub 2019 Feb 21.

L V Prasad Eye Institute, Banjara Hills, Hyderabad.

Purpose: We report a case of premature expression of pseudoexfoliation syndrome with presenile cataract in a 28-year-old lady with primary developmental glaucoma who had undergone glaucoma filtration surgery 26 years ago.

Methods/results: We report a case of a 28-year-old Indian lady with progressive diminution of vision associated with photophobia in the left eye for 5 years and loss of vision in the right eye since childhood. She underwent glaucoma filtration surgery in the left eye at the age of 2 and was on 2 topical glaucoma medications when she presented to us. Read More

Clin Ophthalmol 2019 22;13:199-206. Epub 2019 Jan 22.

Borkenstein & Borkenstein, Privatklinik der Kreuzschwestern Graz, Graz, Austria,

Purpose: The purpose of this study was to describe our surgical experience and evaluate safety and postoperative outcomes of a fully preloaded, monofocal, hydrophobic acrylic intraocular lens (IOL) (CT LUCIA 611P) with a newly designed optic-haptic junction in severe cases of pseudoexfoliation (PXF) syndrome, phacodonesis, and small pupils.

Setting: This study was conducted in Borkenstein & Borkenstein, private practice, Privatklinik der Kreuzschwestern Graz, Austria.

Patients And Methods: This study presents outcomes of 15 eyes of 15 patients implanted with CT LUCIA 611P IOL with improved optical properties and more rigid and wider optic- haptic junction. Read More

Exp Eye Res 2019 Apr 7;181:197-207. Epub 2019 Feb 7.

School of Biological Sciences, National Institute of Science Education and Research (NISER) Bhubaneswar, HBNI, P.O. Bhimpur-Padanpur, Jatni, Khurda, Odisha, 752050, India. Electronic address:

Pseudoexfoliation (PEX), an ocular disorder involving deposition of proteinaceous fibrils on the surface of anterior eye tissues, is a major contributing factor to worldwide glaucoma. Excessive production and accumulation of fibrillar materials in PEX could be an indication of proteostasis imbalance. This study aims at investigating the differential expression of various genes involved in unfolded protein response and ubiquitin proteasome pathway in pseudoexfoliation (PEX) patients compared to non-PEX controls using lens capsule tissue as the study material. Read More

Invest Ophthalmol Vis Sci 2019 Feb;60(2):599-604

Department of Ophthalmology, Seoul National University College of Medicine, Seoul, Korea.

Purpose: The purpose of this study was to determine the rate of ganglion cell-inner plexiform layer (GCIPL) thinning by Cirrus high-definition optical coherence tomography (HD-OCT) in normal eyes and open-angle glaucoma (OAG) and pseudoexfoliation glaucoma (PXG) eyes.

Methods: This was a longitudinal observational study. We evaluated 282 subjects who visited a glaucoma clinic of a tertiary hospital in Korea: 60 healthy eyes, 193 medically treated OAG eyes, and 29 medically treated PXG eyes with a minimum 3-year follow-up involving serial spectral-domain OCT measurement of GCIPL thickness. Read More

Mol Vis 2018 31;24:890-901. Epub 2018 Dec 31.

Department of Biology, University of Patras, Patras, Greece.

Purpose: The aim of this study is to investigate the age-correlation of oxidative stress (OS, assessed by the accumulative OS damage marker protein carbonyls) in aqueous humour (AH; together with protein concentration) and lens epithelial cells plus capsule (LECs/capsule) in patients with cataract (CAT), and also suffering from pseudoexfoliation syndrome (PEX), primary open-angle glaucoma (POAG) and pseudoexfoliation glaucoma (PXG).

Methods: AH samples from 78 male/female patients (21, 20, 19 and 18 with CAT, PEX, PXG, and POAG, respectively), and LECs/capsule samples from 104 male/female patients (34, 32, 18, and 20 with CAT, PEX, PXG and POAG, respectively) were collected during phacoemulsification CAT surgery. Average protein carbonyl concentrations were measured in patients grouped in 5-year age intervals (ranging from 56-60 to 86-90). Read More

Mol Vis 2018 28;24:801-817. Epub 2018 Dec 28.

Department of Ophthalmology, Flinders University, Bedford Park, SA, Australia.

Purpose: Pseudoexfoliation (PEX) syndrome is an age-related progressive disease of the extracellular matrix with ocular manifestations. PEX is clinically diagnosed by the presence of extracellular exfoliative deposits on the anterior surface of the ocular lens. PEX syndrome is a major risk factor for developing glaucoma, the leading cause of irreversible blindness in the world, and is often associated with the development of cataract. Read More

J Glaucoma 2019 Feb;28(2):e36

Department of OphthalmologyKorea University College of Medicine Seoul, Korea.

J Glaucoma 2019 Apr;28(4):e70-e71

Department of Ophthalmology, Korea University College of Medicine, Seoul Korea.

J Glaucoma 2019 Apr;28(4):e69-e70

Department of Ophthalmology, Hospital Universitario Ramón y Cajal.

BMC Ophthalmol 2018 Dec 27;18(1):339. Epub 2018 Dec 27.

Department of Ophthalmology, Ruprecht-Karls-University Heidelberg, 69120, Heidelberg, Germany.

Purpose: To compare efficacy and safety results of an ab interno gel implant in patients with pseudoexfoliation glaucoma (PXG) and primary open angle glaucoma (POAG).

Methods: Retrospective analysis of the medical records of 110 consecutive eyes with open angle glaucoma who had received a XEN45 gel implant between March 2014 and June 2015. Intraocular pressure course, number of glaucoma medications, the need for additional intervention (including needling) and complications were evaluated until 12 months postoperatively. Read More

Acta Ophthalmol 2018 Dec 21. Epub 2018 Dec 21.

Helsinki Retina Research Group, University of Helsinki, Helsinki, Finland.

Purpose: Novel pupil expansion devices are widely recognized for their intraoperative feasibility in safe small pupil cataract surgeries. To assess whether the use of pupil expansion devices affects recovery from cataract surgery.

Methods: A post hoc analysis of five consecutive prospective randomized clinical trials. Read More

Vestn Oftalmol 2018;134(5. Vyp. 2):244-249

Research Institute of Eye Diseases, 11A Rossolimo St., Moscow, Russian Federation, 119021.

The XEN-45 drainage implant is a hypotensive device made of hydrophilic gelatin and stabilized by glutaraldehyde. The implant is designed for modern Microinvasive Glaucoma Surgery (MIGS). Being installed ab interno, the stent drains aqueous fluid from the anterior chamber into the subconjunctival space. Read More

Curr Opin Ophthalmol 2019 Jan;30(1):56-62

Private Practice, Gdańsk, Poland.

Purpose Of Review: The aim of this review was to assess the risk factors and course of postoperative intraocular pressure (IOP) increase in order to determine the optimal the treatment.

Recent Findings: Early postoperative IOP elevation following cataract surgery is a frequent adverse event, and might represent 88% early postoperative complications. The risk factors for IOP elevation following phacoemulsification cataract surgery include residual viscoelastic material, resident performed surgery, glaucoma, pseudoexfoliation syndrome, axial length over 25 mm, tamsulosin intake, topical steroid application in steroid responders. Read More

Graefes Arch Clin Exp Ophthalmol 2019 Feb 28;257(2):349-355. Epub 2018 Nov 28.

Department of Ophthalmology, University of Patras, Medical School, 265 04, Patras, Greece.

Purpose: To evaluate the effectiveness of a single session of micropulse laser trabeculoplasty (MLT) to lower intraocular pressure (IOP) in patients with pseudoexfoliation glaucoma (PEXG).

Methods: In this single-center, one-arm, prospective study patients with PEXG under prostaglandine analogue monotherapy with inadequate IOP control were treated with 360° 532-nm MLT. Patients were evaluated at 1 day, 1 month, 3 months, 6 months, and 12 months post-MLT while they were treated with the same drug regimen as pre-MLT. Read More

Endocr Metab Immune Disord Drug Targets 2019 ;19(2):166-170

Department of Biochemistry, Inonu University Turgut Ozal Medical Center, Malatya, Turkey.

Objective: To investigate whether serum vitamin D levels have an effect on pseudoexfoliation (PEX) glaucoma/syndrome development and on the control of glaucoma in these cases.

Method: A total of 31 cases with PEX glaucoma, 34 cases with the PEX syndrome and 43 control subjects of similar age and sex were included in the study. Vitamin D levels were compared between the groups and also between the cases where glaucoma surgery was performed or not. Read More

Ocul Immunol Inflamm 2018 Nov 13:1-5. Epub 2018 Nov 13.

b Meram School of Medicine, Department of Ophthalmology , Necmettin Erbakan University , Konya , Turkey.

Purpose: To evaluate the association between monocyte count/high-density lipoprotein (HDL) ratio (MHR) and lymphocyte count/monocyte count ratio (LMR) with pseudoexfoliation syndrome (PEXS) and pseudoexfoliation glaucoma (PEXG).

Materials And Methods: A total of 63 participants included in the study. Participants were divided into three groups. Read More

Asia Pac J Ophthalmol (Phila) 2019 Jan-Feb;8(1):55-61. Epub 2018 Nov 13.

Einhorn Clinical Research Center, New York Eye and Ear Infirmary of Mount Sinai, New York, NY.

The first description of exfoliation syndrome (XFS) was presented by John Gustaf Lindberg in his doctoral thesis 100 years ago. The syndrome is an age-related disorder in which abnormal fibrillar extracellular material is produced and accumulates in several ocular tissues. Once thought to be peculiar to Scandinavia, XFS is found in almost every race and ethnic group. Read More

Turk J Ophthalmol 2018 Oct 31;48(5):215-220. Epub 2018 Oct 31.

Eskisehir Osmangazi University Faculty of Medicine, Department of Biostatistics, Eskişehir, Turkey.

Objectives: To investigate the three single nucleotide polymorphisms (SNPs) (rs3825942, rs1048661, and rs2165241) of the gene in pseudoexfoliation syndrome (XFS) and pseudoexfoliation glucoma (XFG) in the Turkish population.

Materials And Methods: DNA was obtained from blood samples of 48 XFS, 58 XFG, and 171 control subjects. Three SNPs (rs3825942, rs1048661, rs2165241) were investigated with real time PCR, a probe-based genotyping method, and melting curve analysis. Read More

Invest Ophthalmol Vis Sci 2018 Nov;59(13):5355-5365

Hamilton Glaucoma Center, Shiley Eye Institute, Department of Ophthalmology, University of California, San Diego, California, United States.

Purpose: To better understand the relationship of lamina cribrosa (LC) and choroid features to the severity of pseudoexfoliation glaucoma (PXG).

Methods: In this cross-sectional study, 137 eyes of 122 subjects (47 eyes with moderate/advanced PXG [mean deviation (MD), -15.0 ± 7. Read More

Ophthalmologica 2019 2;241(3):130-136. Epub 2018 Nov 2.

Department of Ophthalmology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.

Purpose: The aim of this study was to evaluate pseudoexfoliation (PXF) as an independent risk factor for the occurrence of retinal vein occlusion (RVO).

Methods: This is a retrospective cohort study on the records of 300 PXF glaucoma patients (PXF group), 300 non-PXF glaucoma patients, and 599 nonglaucoma non-PXF (nGnP group) patients.

Results: Multivariate analysis resulted in a significant probability for RVO in the PXF (p = 0. Read More

Ophthalmology 2019 Mar 17;126(3):362-371. Epub 2018 Oct 17.

Glaucoma Services, Wilmer Eye Institute, Baltimore, Maryland; Department of Ophthalmology, University of Michigan, Ann Arbor, Michigan.

Purpose: To compare intraoperative complication rates, 1-year visual outcomes, and postoperative complication rates over the first postoperative year in eyes with and without pseudoexfoliation undergoing cataract surgery.

Design: Prospective, comparative, interventional study.

Participants: Nine hundred thirty eyes with cataract and uncomplicated pseudoexfoliation (without phacodonesis, clinically shallow anterior chambers, or pupil size <4 mm) and 476 controls with cataract but without pseudoexfoliation recruited from 4 centers of the Aravind Eye Care System in Southern India. Read More

J Glaucoma 2019 Jan;28(1):38-41

Department of Ophthalmology, Gazi University School of Medicine, Ankara, Turkey.

Purpose: The purpose of the present study was to evaluate the aqueous humor endocan and endostatin levels in patients with pseudoexfoliation (PEX) syndrome and to compare the results with healthy individuals.

Materials And Methods: Twenty nine cataract patients with PEX syndrome (PEX group) and 32 cataract patients without PEX syndrome (control group) were enrolled in the study. Endocan and endostatin were measured in the aqueous humor of the PEX and control groups by enzyme-linked immunosorbent assay. Read More

Eur J Ophthalmol 2018 Oct 14:1120672118805882. Epub 2018 Oct 14.

1 Department of Ophthalmology, Hospital Universitario Ramón y Cajal, Madrid, Spain.

Purpose: To compare peripapillary vascular parameters derived from two optical coherence tomography angiography devices in pseudoexfoliation glaucoma, primary open-angle glaucoma, and healthy controls and to evaluate their diagnostic accuracy.

Methods: Observational, cross-sectional study. In total, 20 eyes with pseudoexfoliation glaucoma, 20 primary open-angle glaucoma eyes matched by peripapillary retinal nerve fiber layer thickness, and 20 control eyes were recruited. Read More

J Glaucoma 2019 Feb;28(2):e35

Department of Ophthalmology, Semmelweis University, Budapest, Hungary.

Acta Ophthalmol 2018 Oct 8. Epub 2018 Oct 8.

Vitreoretinal Surgery Unit, Department of Ophthalmology, Helsinki University Hospital, Helsinki, Finland.

Purpose: To examine the clinical outcomes of intraocular lens (IOL) scleral fixation with the friction knot technique.

Methods: Retrospective case series of 152 eyes of 152 patients with inadequate capsular bag support operated with the friction knot IOL scleral fixation technique by a single surgeon. The fixated IOLs were one-piece or three-piece models all with open loop haptics. Read More

Arch Soc Esp Oftalmol 2018 Dec 2;93(12):573-579. Epub 2018 Oct 2.

Grippo Glaucoma Center, Buenos Aires, Argentina; Universidad de Yale, New Haven, CT, Estados Unidos; Hospital Alemán, Buenos Aires, Argentina. Electronic address:

Objective: To report the results using Micropulse transscleral cyclophotocoagulation (Iridex) in the treatment of glaucoma.

Methods: Retrospective study in adult patients with glaucoma with at least 6 months of follow-up, and only one session of Micropulse. The same surgical technique was used in all cases. Read More

PLoS One 2018 3;13(10):e0204263. Epub 2018 Oct 3.

Beijing Institute of Ophthalmology, Beijing Key Laboratory of Ophthalmology and Visual Sciences, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University; Beijing, China.

Purpose: Systemic inflammation is potentially associated with ocular diseases such as late age-related macular degeneration (AMD). Using the serum concentration of high-sensitive C-reactive protein (hs-CRP) as surrogate of systemic inflammation, we examined potential associations between the serum hs-CRP concentration and the presence and degree of eye diseases.

Methods: The population-based Beijing Eye Study included 3468 Chinese individuals. Read More

Ophthalmology 2019 Feb 29;126(2):223-232. Epub 2018 Sep 29.

Department of Ophthalmology, Western University, Ontario, Canada. Electronic address:

Purpose: The effectiveness of selective laser trabeculoplasty (SLT) was compared with argon laser trabeculoplasty (ALT) in a randomized clinical trial for patients with medically uncontrolled open-angle glaucoma who have previously received 360° SLT.

Design: An active equivalence parallel armed randomized control trial.

Participants: Patients with open-angle glaucoma including pigmentary dispersion syndrome and pseudoexfoliation syndrome were enrolled into the study from 7 different sites across Canada. Read More

Sci Rep 2018 Sep 28;8(1):14533. Epub 2018 Sep 28.

Tottori University, Division of Ophthalmology and Visual Science, Faculty of Medicine, 36-1 Nishi-cho, Yonago, Tottori, 683-8504, Japan.

Glaucoma is a leading cause of blindness worldwide. Purpose of this study was to identify molecular markers that were significantly correlated with presence of glaucoma and outcome of glaucoma surgery. To accomplish this, we determined the profiles of pro-inflammatory cytokines in the aqueous humor of 101 glaucoma patients; 31 primary open angle glaucoma (POAG), 38 pseudoexfoliation glaucoma (PEG), and 32 neovascular glaucoma (NVG). Read More

J Trace Elem Med Biol 2018 Dec 19;50:67-72. Epub 2018 Jun 19.

Schwabachanlage 6, 91054 Erlangen, Germany. Electronic address:

Purpose: Selenium supplementation was seen to be linked to glaucoma disease in a previous study (Lillico A. JE, Reid M et al. (2002) Selenium Supplementation and Risk of Glaucoma in the NPC trial University of Arizona, Tucson, AZ. Read More

Br J Ophthalmol 2018 Sep 24. Epub 2018 Sep 24.

RS Mehta Jain Department of Biochemistry and Cell Biology, KBIRVO block, Vision Research Foundation, Sankara Nethralaya, Chennai, Tamil Nadu, India

Background: Pseudoexfoliation syndrome (PXF) is an idiopathic, elastogenesis-associated systemic disease characterised by amyloid-like material aggregates in the eye. Elevated plasma and aqueous humour (aqH) homocysteine (Hcy) is reportedly associated with PXF. This study is aimed to probe Hcy-mediated alterations in elastin expression. Read More

Acta Ophthalmol 2019 Feb 20;97(1):80-83. Epub 2018 Sep 20.

Departments of Neuroscience, Ophthalmology, and Surgical Sciences, Uppsala University, Uppsala, Sweden.

Purpose: To study the relationship between pseudoexfoliation (PEX) and aortic aneurysm in a population with a high prevalence of PEX.

Methods: Survival analyses were performed in a cohort of 735 residents aged 65-74 years, examined in a population survey in the municipality of Tierp, Sweden, 1984-1986. To expand the sample size, 1040 people were recruited by means of glaucoma case records established at the Eye Department in Tierp in 1978-2007. Read More

Arq Bras Oftalmol 2018 Sep-Oct;81(5):437-439

Department of Ophthalmology, Universidade Federal de São Paulo, São Paulo, SP, Brazil.

A 89-year-old Black female with a 6-year history of advanced open-angle glaucoma was referred to the Glaucoma Service of the Ophthalmology Department - Federal University of São Paulo (UNIFESP). Best-corrected visual acuity was 20/400 in the right eye and 20/60 in the left eye. Pseudoexfoliation material was observed at the iris border, angle, and the anterior lens surface. Read More

Eur J Ophthalmol 2018 Sep 12:1120672118799622. Epub 2018 Sep 12.

1 Helsinki Retina Research Group, University of Helsinki, Helsinki, Finland.

Background: The purpose of the study was to identify macular edema after cataract surgery in eyes with and without pseudoexfoliation syndrome. The study was a post-hoc analysis of a randomized, double-blind, prospective single-center study. Patients were enrolled between January 2016 and October 2016 as per the national guidelines for the management of cataract in the Department of Ophthalmology, Kymenlaakso Central Hospital, Kotka, Finland. Read More

Pan Afr Med J 2018 18;30:47. Epub 2018 May 18.

Faculté de Médecine et de Pharmacie de Fès CHU Hassan II, Fes, Maroc.

We here report the case of a 79-year old patient who underwent cataract by phacoemulsification associated with preoperative left and right eyes pseudo-capsular exfoliation in 2000. He had pseudo-exfoliative glaucoma with recurrence on the implant. Read More

Eur J Ophthalmol 2018 Sep 6:1120672118795405. Epub 2018 Sep 6.

1 Advanced Eye Centre, PGIMER, Chandigarh, Chandigarh, India.

Introduction: Pseudoexfoliation syndrome is commonly associated with pseudoexfoliation glaucoma. The two nonsynonymous single-nucleotide polymorphisms rs1048661 (R141L) and rs3825942 (G153D) within exon 1 of LOXL1 gene have been found to confer risk of pseudoexfoliation syndrome and pseudoexfoliation glaucoma in different geographical populations. This study aims to find association between two nonsynonymous single-nucleotide polymorphisms with pseudoexfoliation syndrome and pseudoexfoliation glaucoma in North Indian population. Read More

Acta Ophthalmol 2018 Nov 4;96(7):e859-e864. Epub 2018 Sep 4.

1st Department of Ophthalmology, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece.

Purpose: To assess the overdiagnosis of open-angle glaucoma (OAG) and to investigate associated factors.

Methods: This was a cross-sectional, population-based study of an urban Caucasian population in northern Greece. Randomly selected subjects ≥60 years (n = 2554) participated in the Thessaloniki Eye Study. Read More

Ophthalmic Genet 2018 10 27;39(5):603-609. Epub 2018 Aug 27.

b Laboratory of Research and Clinical Applications in Ophthalmology, 1st Department of Ophthalmology , School of Medicine, Aristotle University of Thessaloniki, AHEPA Hospital , Thessaloniki , Greece.

Background: Pseudoexfoliation syndrome (PEX) and glaucoma (pseudoexfoliative glaucoma; PEXG, primary open-angle glaucoma; POAG) have mainly been studied for their associations with genes' polymorphisms. The purpose of this exploratory study was to investigate the role of polymorphisms in genes encoding for micro RNAs (miRNAs) and in genes related to miRNA biogenesis.

Material And Methods: In the present genetic association study, ninety-two polymorphisms were investigated for their contribution to PEX (n = 203), PEXG (n = 38), and POAG (n = 40) pathogenesis compared to a control group (n = 188). Read More

Eur J Ophthalmol 2018 Aug 27:1120672118795063. Epub 2018 Aug 27.

Department of Ophthalmology, San Pedro Hospital, Logroño, Spain.

Purpose: To evaluate the intraocular pressure-lowering effect, the safety profile, and the success rate of the XEN45 Gel Stent (Allergan, Dublin, Ireland) in patients with pseudoexfoliative glaucoma.

Methods: Retrospective study conducted on patients with pseudoexfoliative glaucoma, with or without cataract, who underwent XEN45 implantation surgery with subconjunctival mitomycin-C and had a minimum postoperative follow-up period of 12 months. The primary outcome measure was intraocular pressure reduction at 1 year as compared to baseline. Read More

J Glaucoma 2018 Nov;27(11):1009-1016

Department of Ophthalmology, Korea University College of Medicine, Seoul, Korea.

Purpose: The aim of this study was to compare the peripapillary vessel density between eyes with pseudoexfoliation glaucoma (PXG) and eyes with primary open-angle glaucoma (POAG).

Methods: Peripapillary vessel density in the radial peripapillary capillaries was assessed using optical coherence tomography angiography, and compared between patients with PXG and those with POAG, matched for age and mean deviation (MD) of standard automated perimetry. The vessel density was measured between the optic disc margin and 750 μm from the optic disc margin. Read More

J Glaucoma 2018 Nov;27(11):976-980

Department of Clinical Sciences in Malmö, Ophthalmology, Lund University, Malmö.

Purpose: The purpose of this study was to assess the intraocular pressure (IOP) - reducing effect of latanoprost in treatment-naïve patients with newly detected open-angle glaucoma with no restriction of the level of untreated IOP.

Methods: Eighty-six patients (105 eyes) with a diagnosis of open-angle glaucoma received IOP-lowering therapy with latanoprost. The IOP reduction 1 and 3 months after initiation of treatment was recorded. Read More

Lasers Med Sci 2019 Mar 13;34(2):353-357. Epub 2018 Aug 13.

Faculty of Medicine, AL-Azhar University, Cairo, Egypt.

Aim: The purpose of this study is to identify the effect of Nd: YAG laser posterior capsulotomy using an anterior chamber morphology.

Methods: This study included 42 eyes of 33 pseudophakic patients with visually significant PCO after uncomplicated cataract surgery. Exclusion criteria were complications related to cataract surgery, corneal pathology, pseudoexfoliation, glaucoma, uveitis, previous ocular surgery or trauma, and posterior segment pathology. Read More

Br J Ophthalmol 2018 Nov 12;102(11):1477-1482. Epub 2018 Aug 12.

Allen Foster Community Eye Health Research Centre, Gullapalli Pratibha Rao International Centre for Advancement of Rural Eye Care, L V Prasad Eye Institute, Hyderabad, India.

Aim: To evaluate glaucoma-associated mortality in a rural cohort in India.

Methods: The study cohort comprised individuals aged 40 years and above who took part in the Andhra Pradesh Eye Disease Study (APEDS1) during 1996-2000. All participants underwent detailed comprehensive eye examination. Read More