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BMC Med Genet 2020 Jul 8;21(1):145. Epub 2020 Jul 8.

Department of Ophthalmology, College of Medicine, King Saud University, P.O. Box 245, Riyadh, 11411, Saudi Arabia.

Background: Glaucoma is a polygenic neurodegenerative disease and the second most common cause of blindness in Saudi Arabia. To test the hypothesis that genetic variants in the genes involved in the bone morphogenic protein (BMP) signaling pathway may be associated with glaucoma, we investigated the association between 3' untranslated region variants, rs12997 in ACVR1 and rs1043784 in BMP6, and primary angle-closure glaucoma (PACG) and pseudoexfoliation glaucoma (PXG).

Methods: In a case-control study, TaqMan® real-time PCR-based genotyping was done in 444 subjects consisting of 250 controls, 101 PACG and 95 PXG cases, and tested for genetic association with glaucoma-types and other clinical phenotypes. Read More

Int Ophthalmol 2020 Jun 26. Epub 2020 Jun 26.

Center for Ophthalmic Specialized Care (COS), Clinic Montchoisi, Ave Beaumont 9, 1012, Lausanne, Switzerland.

Purpose: Pseudoexfoliation syndrome is common in elderly patients and is associated with intraocular pressure elevation. Goniowash is a novel surgical technique to remove pseudoexfoliation material from the irido-corneal angle to decrease intraocular pressure. We assessed the long-term efficacy of Goniowash on relevant parameters in patients with pseudoexfoliation syndrome, after cataract surgery. Read More

Ophthalmologe 2020 Jun 25. Epub 2020 Jun 25.

Universitäts-Augenklinik, Leitung der Sektion Kinderaugenheilkunde, Strabologie/Orthoptik, Neuroophthalmologie, Charité - Universitätsmedizin Berlin, Augustenburger Platz 1, 13353, Berlin, Deutschland.

A 53-year-old female patient presented with increased light sensitivity 3 weeks after oral intake of moxifloxacin tablets for an upper respiratory tract infection. The symptoms were anisocoria and the pupils did not react to light or accommodation. The examination of the anterior segment of the eye revealed extensive bilateral iris transillumination defects (ITD). Read More

Rev Fac Cien Med Univ Nac Cordoba 2020 04 7;77(2):68-72. Epub 2020 Apr 7.

Cátedra de Física Biomédica. FCM. UNC.

Introduction: Pseudoexfoliation Syndrome (PEX) is a genetic-inherited disorder, consisting of the deposition of elastin microfibers in intra and extraocular tissue. PEX is one of the most common identifiable secondary causes of glaucoma. Several studies have associated PEX with systemic conditions and the finding of fibrillar material in the structures of the inner ear, similar to that of pseudoexfoliation detected in the eye, has been described. Read More

Clin Ophthalmol 2020 21;14:1373-1381. Epub 2020 May 21.

Department of Diagnostics and Microsurgery of Glaucoma, Medical University of Lublin, Lublin, Poland.

Purpose: The aim of this study was to describe clinical characteristics of glaucomatous optic neuropathy in treated Polish patients with pseudoexfoliative glaucoma.

Methods: In the course of the study, 348 eyes of 231 patients with pseudoexfoliative glaucoma. The patients involved in the study were treated in the Department of Diagnostic and Microsurgery of Glaucoma in Lublin between 2012 and 2019. Read More

PLoS One 2020 29;15(5):e0233268. Epub 2020 May 29.

Glaucoma Service, LV Prasad Eye Institute, Vijayawada, Andhra Pradesh, India.

Purpose: To analyse the disease burden of pseudoexfoliation (PXF) disease stages from East and South India.

Design: Prospective hospital based study of patients seen at 4 tertiary centres.

Subjects, Participants, And/or Controls: Consecutive old and new patients of pseudoexfoliation with normal intraocular pressure (IOP), raised IOP (PXF with Ocular hypertension, OHT) and irreversible disc/field changes (pseudoexfoliation glaucoma, PXG) seen from April 2016-March 2017 at a tertiary centre in Odisha, East India and 3 centres in Andhra Pradesh and Telangana, South India, recruited into the prospective study were screened for baseline characteristics. Read More

Indian J Ophthalmol 2020 Jun;68(6):1090-1094

L.V. Prasad Eye Institute, Bhubaneswar, Odisha, India.

Purpose: This study aims to evaluate efficacy and outcomes of manual small incision cataract surgery with trabeculectomy (Group 1) and phacoemulsification with trabeculectomy (Group 2) in pseudoexfoliation glaucoma (PXG).

Methods: In this retrospective comparative observational case series, All patients with PXG who underwent either small incision cataract surgery or phacoemulsification with trabeculectomy from 2011-2015 were studied. Data compared included best corrected visual acuity (BCVA), intraocular pressure (IOP), total surgical time, and incidence of intra/postoperative complications. Read More

Int J Ophthalmol 2020 18;13(5):744-754. Epub 2020 May 18.

Department of Ophthalmology, Ankara University Faculty of Medicine, Ankara 06620, Turkey.

Aim: To evaluate and compare the peripapillary and retinal vasculature changes in primary open angle glaucoma (POAG), pseudoexfoliation glaucoma (PXG), ocular hypertension (OHT) and normal eyes using optical coherence tomography angiography (OCTA).

Methods: A total of 114 POAG, PXG and OHT eyes of 60 patients and 46 eyes of 23 healthy control participants with good quality OCTA images were included. The PXG, POAG, OHT, and control groups (aged 68. Read More

Ophthalmic Res 2020 Apr 30. Epub 2020 Apr 30.

Objective: To evaluate the sensitivity and specificity of pseudoexfoliation syndrome diagnosis in pseudophakic patients and potential means of improving it.

Methods: This prospective, nonrandomized study comprised 41 consecutive patients (41 eyes) scheduled for cataract surgery at a tertiary medical center during 2016-2017. Preoperatively, all patients underwent a detailed slit-lamp examination, including gonioscopic assessment of the iridocorneal angle. Read More

Sci Rep 2020 Apr 29;10(1):7260. Epub 2020 Apr 29.

Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan.

This study investigated corneal endothelial cell density (ECD) in pseudoexfoliation (PEX) syndrome patients and evaluated the clinical factors associated with ECD for 51 eyes of 41 phakic patients with pseudoexfoliation (PEX group) and 201 eyes of 117 patients with age-related cataracts (control group) as an age-matched control to the PEX group. Variable clinical factors, including ECD, central corneal thickness (CCT), anterior chamber depth (ACD), number of anti-glaucoma eye drops and severity of PEX, were examined using multivariate analyses. Severity of PEX was as follows: Mild in 28 eyes, Moderate in 16 eyes, and Severe in 7 eyes. Read More

Indian J Ophthalmol 2020 May;68(5):787-792

Department of Glaucoma, Narayana Nethralaya Foundation, Bengaluru, Karnataka, India.

Purpose: To compare the corneal biomechanical parameters among pseudoexfoliation syndrome (PXF), pseudoexfoliation glaucoma (PXG), and healthy controls using Corvis Scheimpflug Technology (ST).

Methods: A prospective, cross-sectional study of 141 treatment-naïve eyes that underwent Corvis ST was conducted. These included 42 eyes with PXF, 17 eyes of PXF with ocular hypertension (PXF + OHT) defined as intraocular pressure (IOP)> 21 mmHg without disc/field changes, 37 eyes with PXG, and 45 healthy controls. Read More

Graefes Arch Clin Exp Ophthalmol 2020 Jul 16;258(7):1493-1501. Epub 2020 Apr 16.

Department of Ophthalmology, Ulucanlar Eye Education and Research Hospital, University of Health Sciences, Kale Mahallesi, Ulucanlar Caddesi, No:59, 06250, Altındağ/Ankara, Turkey.

Purpose: To evaluate vascular microcirculation changes of the optic nerve head (ONH) in the patients with asymmetric pseudoexfoliative glaucoma (XFG) using optical coherence tomography angiography (OCTA) and to compare vessel density (VD) results with healthy individuals.

Methods: This prospective study enrolled 120 eyes in total. The eyes were divided into 3 groups: 40 glaucomatous and 40 non-glaucomatous fellow eyes without clinically pseudoexfoliation material (XFM) of patients with asymmetric XFG, and 40 healthy eyes as controls. Read More

J Ophthalmol 2020 23;2020:7345687. Epub 2020 Mar 23.

Department of Ophthalmology, Lithuanian University of Health Sciences, Kaunas, Lithuania.

Glaucoma patients often require long-term or even lifelong medical antiglaucomatous treatment. Benzalkonium chloride (BAK) is the most frequently used preservative in medical glaucoma treatment. Laser flare photometry is the noninvasive quantitative measurement of anterior chamber protein level and helps tracking intraocular inflammation. Read More

J Ophthalmol 2020 23;2020:1723691. Epub 2020 Mar 23.

Department of Ophthalmology, Shijiazhuang No. 1 Hospital, Hebei 050000, China.

Purpose: To compare long-term effects of trabeculectomy on pseudoexfoliation glaucoma (PXG) and primary open-angle glaucoma (POAG).

Methods: This retrospective case-control study included 53 eyes of PXG and 76 eyes of POAG. Intraocular pressure (IOP), number of antiglaucoma medications used, surgical success rate, and occurrence of complications were observed and statistically analyzed in both groups at 3 and 6 months and at 1, 3, and 5 years after trabeculectomy. Read More

J Cataract Refract Surg 2020 04;46(4):555-561

From the Ophthalmology Department, Centro Hospitalar São João (Oliveira-Ferreira, Leuzinger-Dias, Tavares Ferreira, Macedo, Falcão-Reis) and Surgery and Physiology Department, Faculty of Medicine of Porto University (Falcão-Reis), Oporto, Portugal.

Purpose: To determine the incidence of intraoperative complications of phacoemulsification cataract surgery in a teaching hospital and to compare the intraoperative complication rate between resident trainees and staff ophthalmologists, to ascertain the overall rate of intraocular pressure (IOP) elevation on postoperative day 1 (POD1), and, again, to compare this value between resident trainees and staff surgeons.

Setting: Centro Hospitalar São João, Oporto, Portugal.

Design: Retrospective study. Read More

Eur J Ophthalmol 2020 Apr 8:1120672120914536. Epub 2020 Apr 8.

University of Health Sciences, Ulucanlar Eye Education and Research Hospital, Ankara, Turkey.

Purpose: The aims of this study were to compare the biometric parameters and axial lengths of eyes with phacomorphic glaucoma and mature cataract and to identify differences that might predispose to development of phacomorphic glaucoma.

Methods: Three hundred forty-two patients were enrolled in this retrospective study. The eyes were divided into four groups-Group (G)1: phacomorphic glaucoma ( = 29), G2: mature cataract ( = 313), G3: contralateral phacomorphic glaucoma ( = 29), and G4: contralateral mature cataract ( = 313). Read More

Vestn Oftalmol 2020 ;136(1):36-41

S.N. Fyodorov National Medical Research Center "MNTK "Eye Microsurgery", 59A Beskudnikovsky Blvd., Moscow, Russian Federation, 127486.

The universally established method for effective and less-invasive reduction of the intraocular pressure (IOP) in patients with primary open-angle glaucoma (POAG) is a two-step method consisting of non-penetrating deep sclerectomy (NDSE) followed by laser goniopuncture of the Descemet's membrane (Descemet's goniopuncture; DGP). However, the hypotensive effect can diminish at different times during the follow-up due to excessive scarring in surgically formed outflow tracts (SFOT).

Purpose: To evaluate the condition of SFOT in dynamics with Visante OCT after one-step combined laser technique consisting of modified selective laser activation of the trabecula (MSLAT) and DGP in advanced POAG patients with normalized IOP who have pronounced pigmentation of the trabecular meshwork and stage II pseudoexfoliation syndrome (PES). Read More

Vestn Oftalmol 2020 ;136(1):25-35

Chelyabinsk Regional Clinical Hospital No. 3, 287 Pobedy av., Chelyabinsk, Russian Federation, 454021.

Up to now, there has not been a comparison of spatial contrast sensitivity (SCS) in patients with primary and pseudoexfoliation open-angle glaucoma (POAG; PEG) and ophthalmic hypertension (OH).

Purpose: To study the characteristics of SCS in patients with POAG, PEG (as well as in the paired eye without glaucoma) and OH.

Material And Methods: The work was performed in the period from 2011 to July 2017. Read More

Laeknabladid 2020 04;106(4):187-192

University of Iceland, Ophthalmology department of Landspitali University Hospital, Iceland.

Introduction: Glaucoma is a degenerative disease in the optic nerve with associated visual field defects (VFD). Trabeculectomy is the most common glaucoma surgery. Surgery is indicated if glaucomatous optic neuropathy progresses despite tolerated medical treatment or in patients with severe VFD. Read More

Eur J Ophthalmol 2020 Mar 31:1120672120914231. Epub 2020 Mar 31.

Department of Ophthalmology, Faculty of Medicine, Ankara University, Ankara, Turkey.

Purpose: The aim of this study is to compare the outcomes of micropulse transscleral cyclophotocoagulation between primary open-angle glaucoma, pseudoexfoliation glaucoma, and other types of secondary glaucoma.

Methods: Outcomes of 96 consecutive patients with refractory, end-stage glaucoma treated with micropulse transscleral cyclophotocoagulation were retrospectively reviewed. Follow-up examinations were performed on a regular basis until 12 months postoperatively. Read More

Int Ophthalmol 2020 Jul 24;40(7):1731-1737. Epub 2020 Mar 24.

Ophthalmology Department, Istanbul Medipol University, Istanbul, Turkey.

Purpose: This study investigates the relationship between plasma homocysteine levels, anterior chamber depth (ACD), and pseudoexfoliation glaucoma (PEXG) in patients with pseudoexfoliation syndrome.

Methods: Sixty patients (F:M = 35:25) with pseudoexfoliation (PEX) were divided into two groups based on their plasma homocysteine levels; group 1 (< 20 µmol/L, normal) and group 2 (≥ 20 µmol/L, high). Intraocular pressure (IOP) and ACD values as well as plasma homocysteine levels were compared between the two groups. Read More

Acta Ophthalmol 2020 Mar 12. Epub 2020 Mar 12.

Department of Ophthalmology, University of Tokyo, Graduate School of Medicine, Tokyo, Japan.

Purpose: To report the prevalence of pseudoexfoliation (PEX) syndrome and glaucoma associated with PEX (PEX-G) and their relating factors of them in a south-western island of Japan.

Methods: A population-based survey of all residents aged ≥ 40 years was conducted in Kumejima, Okinawa, Japan, and 3762 subjects (participation rate, 81.2%) underwent detailed ophthalmic examinations. Read More

Mol Omics 2020 Mar 9. Epub 2020 Mar 9.

Bascom Palmer Eye Institute, University of Miami, Miami, Florida, USA. and Miami Integrative Metabolomics Research Center, University of Miami, Miami, Florida, USA.

Pseudoexfoliation (PEX) is a known cause of secondary open angle glaucoma. PEX glaucoma is associated with structural and metabolic changes in the eye. Despite similarities, PEX and primary open angle glaucoma (POAG) may have differences in the composition of metabolites. Read More

Klin Monbl Augenheilkd 2020 Apr 4;237(4):392-395. Epub 2020 Mar 4.

Department of Ophthalmology, University Hospital Basel, Basel, Switzerland.

Objective: In this report, we investigated the association between the intraocular pressure (IOP) values by two different measurement methods and the corneal biomechanical properties in a patient with keratoconus and secondary glaucoma due to pseudoexfoliation syndrome who developed a marked elevation of intraocular pressure in the right eye.

Methods: IOP was measured over a period of 3 days with Goldmann applanation tonometry (GAT) and dynamic contour tonometry (Pascal tonometry, DCT). Corneal hysteresis (CH) and corneal resistance factor (CRF) were estimated with the aid of an ocular response analyzer (ORA). Read More

J Hum Genet 2020 Jun 3;65(6):517-529. Epub 2020 Mar 3.

School of Biological Sciences, National Institute of Science Education and Research (NISER), HBNI, P.O. Bhimpur-Padanpur, Jatni, Khurda, Bhubaneswar, Odisha, 752050, India.

This study is intended to investigate the epigenetic regulation of the most conserved molecular chaperone, HSP70 and its potential role in the pathophysiology of pseudoexfoliation syndrome (PEXS) and glaucoma (PEXG), a protein aggregopathy, contributing significantly to world blindness. Expression levels of HSP70 were significantly decreased in the lens capsule (LC) of PEXS but not in PEXG compared with that in control. Bisulfite sequencing of the LC of the study subjects revealed that the CpG islands (CGIs) located in the exonic region but not in the promoter region of HSP70 displayed hypermethylation only in PEXS individuals. Read More

J Cataract Refract Surg 2020 02;46(2):188-192

From the Department of Ophthalmology (Shajari, Mackert, Langer, Kreutzer, Wolf, Priglinger, Mayer), University Hospital, LMU Munich, Munich, Germany; and Department of Ophthalmology (Kohnen), Goethe University, Frankfurt, Germany.

Purpose: To implant a small-aperture intraocular lens (IOL) (IC-8) in eyes with severe corneal irregularities to reduce higher-order aberrations and provide better central visual acuity.

Setting: University Hospital, LMU Munich, Germany.

Design: Prospective nonrandomized interventional case series. Read More

J Glaucoma 2020 Jun;29(6):417-422

UCD Clinical Research Centre, UCD School of Medicine, University College Dublin.

Precis: High-risk alleles of risk-associated single-nucleotide polymorphisms (SNPs) within the lysyl oxidase-like 1 (LOXL1) gene are associated with pseudoexfoliation in patients recruited from an Irish population.

Purpose: SNPs within the LOXL1 gene have been identified as a major risk factor for pseudoexfoliation syndrome (PXF) and pseudoexfoliation glaucoma (PXFG), specifically SNPs within exon 1 and intron 1 regions of the gene. The common haplotype (G-G) of 2 SNPs within exon 1, rs1048661, and rs3825942, is the strongest associated risk factor for PXF in white populations, but is switched in some populations to act as protective or low risk. Read More

J Glaucoma 2020 May;29(5):381-385

Department of Ophthalmology, Asan Medical Center, College of Medicine University of Ulsan, Seoul, Korea.

Precis: Pseudoexfoliation glaucoma eyes had a similar level of peripapillary and superficial macular vessel densities compared with primary open-angle glaucoma eyes matched for age and glaucoma severity when assessed by optical coherence tomography angiography (OCT-A).

Purpose: To compare vessel density (VD) measured by OCT-A between primary open-angle glaucoma (POAG) and pseudoexfoliation glaucoma (PXG) in the peripapillary and macular areas.

Materials And Methods: The circumpapillary (cpVD), parafoveal (pfVD), and perifoveal vessel densities (perifVD) were obtained using OCT-A (AngioVue/RTVue-XR) in 98 eyes from 98 subjects [age, visual acuity, visual field (VF) mean deviation (MD) matched 49 POAG and 49 PXG eyes]. Read More

Exp Eye Res 2020 Apr 15;193:107975. Epub 2020 Feb 15.

UCD Clinical Research Centre, School of Medicine, University College Dublin, Ireland.

Lysyl Oxidase Like 1 (LOXL1) is a gene that encodes for the LOXL1 enzyme. This enzyme is required for elastin biogenesis and collagen cross-linking, polymerising tropoelastin monomers into elastin polymers. Its main role is in elastin homeostasis and matrix remodelling during injury, fibrosis and cancer development. Read More

Indian J Ophthalmol 2020 03;68(3):471-474

Department of Glaucoma, Aravind Eye Hospital, Coimbatore, Tamil Nadu, India.

Purpose: To assess the quality and accuracy of glaucoma referrals from ophthalmologist.

Methods: Retrospective review of patients chart with referral letter to a tertiary glaucoma center between January and December 2017. Patients aged <16 years, lens-induced glaucoma, uveitic glaucoma, and glaucoma following retinal and corneal surgery were excluded. Read More

BMC Med Genet 2020 02 12;21(1):32. Epub 2020 Feb 12.

Mycobacteriology Research Centre (MRC), National Research Institute of Tuberculosis and Lung Disease (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Background: The involvement of cytokines in pathogenesis of pseudoexfoliation syndrome and glaucoma has been demonstrated in several studies. The aim of the present study was to explore the association between three promoter polymorphisms -592C/A (rs1800872), - 819C/T (rs1800871) and -1082A/G (rs1800896) of interleukin 10 (IL-10) gene with susceptibility to pseudoexfoliation syndrome (PEX), pseudoexfoliative glaucoma (PEXG), and primary open-angle glaucoma (POAG).

Methods: In this study, 114 PEX, 118 PEXG, 114 POAG patients and 126 healthy individuals from Iranian population were participated. Read More

Hum Mol Genet 2020 Feb 10. Epub 2020 Feb 10.

Department of Ophthalmology, Duke University, Duke Eye Center AERI Rm 4008, 2351 Erwin Road Durham, NC 27710, USA.

Individuals with pseudoexfoliation (PEX) syndrome exhibit various connective tissue pathologies associated with dysregulated extracellular matrix homeostasis. PEX glaucoma is a common, aggressive form of open-angle glaucoma resulting from the deposition of fibrillary material in the conventional outflow pathway. However, the molecular mechanisms that drive pathogenesis and genetic risk remain poorly understood. Read More

Clin Exp Ophthalmol 2020 May 13;48(4):442-449. Epub 2020 Feb 13.

Department of Ophthalmology, Flinders University, Flinders Medical Centre, Adelaide, South Australia, Australia.

Importance: Cataract and primary open-angle glaucoma (POAG) commonly co-exist, and cataract surgery is thought to reduce intraocular pressure (IOP), the major modifiable risk factor of POAG.

Background: Previous studies exploring the effect of cataract surgery on IOP are limited by retrospective design, lack of a control group, medication use and washout and loss to follow up.

Design: Prospective, multicentre, matched case-control Australian study. Read More

Klin Monbl Augenheilkd 2020 Feb 3. Epub 2020 Feb 3.

Klinik und Poliklinik für Augenheilkunde, Universitätsklinikum Hamburg-Eppendorf.

Background: Various procedures are available for the treatment of advanced glaucoma. We examined the efficacy and safety of fractionated cyclophotocoagulation (CPC) with up to ten laser spots for advanced primary open-angle glaucoma (POAG) and pseudoexfoliation (PEX) glaucoma treated with maximal topical therapy or eye-drop intolerance.

Material Und Methods: This retrospective study evaluated data from 297 eyes with advanced POAG and PEX glaucoma which received 10 applications of CPC between February 2012 and June 2017. Read More

Vestn Oftalmol 2019 ;135(6):100-107

Volga District Medical Centre, Federal Medical and Biological Agency, 2 Nizhnevolgskaya Naberejnaya, Nizhny Novgorod, Russian Federation, 603001.

Peripapillary and macular retinoschisis is one of the rare manifestations of advanced glaucoma of different types. The article presents a case report and a mini-review. Peripapillary and macular retinoschisis with visual deterioration was diagnosed in a patient with advanced decompensated open-angle glaucoma and pseudoexfoliation syndrome. Read More

Curr Med Imaging Rev 2019;15(7):637-644

Department of Ophthalmology, Yildirim Beyazit University, Ataturk Research and Training Hospital, Ankara, Turkey.

Purpose: To investigate the biomechanical properties of the optic nerve head in patients with Pseudoexfoliation (PEX) glaucoma using Real-time Elastography (RTE) and to compare these results with those of Primary Open Angle Glaucoma (POAG) patients and healthy subjects.

Methods: Twenty eyes of 20 PEX glaucoma patients (PEX group), 20 eyes of 20 POAG patients (POAG group), and 20 eyes of 20 healthy subjects (control group) were enrolled in this prospective study. The strain Ratios of Orbital Fat to Optic Nerve head (ROFON) and lateral rectus muscle to optic nerve head (RLRON) were determined. Read More

J Ophthalmol 2019 23;2019:2424956. Epub 2019 Dec 23.

Clinical Department of Internal Medicine and Specialistics, Department of Advanced Clinical and Surgical Sciences, University of Campania "Luigi Vanvitelli", 80138 Naples, Italy.

Network medicine is a molecular-bioinformatic approach analyzing gene-gene interactions that can perturb the human interactome. This review focuses on epigenetic changes involved in several ocular diseases, such as DNA methylation, histone and nonhistone post-translational modifications, and noncoding RNA regulators. Although changes in aberrant DNA methylation play a major role in the pathogenesis of most ocular diseases, histone modifications are seldom investigated. Read More

Eye Vis (Lond) 2020 10;7. Epub 2020 Jan 10.

Ophthalmologikum Dr.Neuhann, Augentagesklinik Marienplatz, Marienplatz 18-19, 80331 Munich, Germany.

Background: The study aimed to investigate the 24-month safety and efficacy of implantation of two second-generation iStent inject trabecular micro-bypass stents with concomitant cataract surgery.

Methods: This consecutive case series included 164 eyes of 109 patients implanted with the iStent inject® device with concomitant cataract surgery. The series was comprised of eyes with primary open-angle glaucoma ( = 84), pseudoexfoliation glaucoma ( = 42), normal-tension glaucoma ( = 18), and ocular hypertension ( = 20). Read More

BMC Ophthalmol 2020 Jan 6;20(1):13. Epub 2020 Jan 6.

Harkness Eye Institute, Columbia University Irving Medical Center, New York, NY, 10032, USA.

Background: Bilateral Acute Depigmentation of the Iris (BADI) is a condition which was first described in a case series from Turkey by Tugal-Tutkin and Urgancioglu in (Graefes Arch Clin Exp Ophthalmol 244:742-6, 2006). The condition is characterized by bilateral acute depigmentation and discoloration of the iris stroma, pigment dispersion, and deposition of pigment in the angle. In our case we report a patient who developed BADI after receiving pitcher plant extract injections for chronic migraine, while her identical twin sister has normal iris architecture and pigmentation and never received any pitcher plant injections. Read More

Free Radic Biol Med 2020 02 15;147:61-68. Epub 2019 Dec 15.

Health Research Institute, National Institute of Advanced Industrial Science and Technology, 2217-14 Hayashicho, Takamatsu, Kagawa, 761-0395, Japan.

We reported previously that enzymatic and singlet oxygen-mediated fatty acid oxidation may be major oxidation pathways in subjects with primary open angle glaucoma, based on measurement of serum levels of hydroxylinoleate (HODE) and hydroxyarachidonate (HETE) isomers after reduction and saponification. In this study, we measured serum levels of HODE and HETE isomers to investigate the pathogenesis of exfoliation syndrome (EX). In total, 311 Japanese subjects comprising EX patients (n = 192) and non-glaucomatous control subjects (n = 119) were included in this study. Read More

Iran J Public Health 2019 Oct;48(10):1827-1837

Eye Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

Background: Pseudoexfoliation syndrome (XFS) is pathogenetically related to exfoliative glaucoma (XFG), which is the most common type of secondary glaucoma. We aimed to investigate the relationship between SNPs (rs1048661, rs3825942) and XFS and/or XFG in a cohort of Iranian subjects.

Methods: This cross-sectional study investigated possible association between LOXL1 gene polymorphisms and exfoliative glaucoma in Northeastern part of Iran between May 2014 and May 2015. Read More

Graefes Arch Clin Exp Ophthalmol 2020 Feb 7;258(2):387-393. Epub 2019 Dec 7.

Department of Ophthalmology, RWTH Aachen University, Pauwelsstr. 30, 52074, Aachen, Germany.

Background: Canaloplasty is a well-established non-penetrating glaucoma surgery. Unsuccessful outcomes can be enhanced by micro-invasive 360° suture trabeculotomy (360°trabeculotomy), analyzed in this study.

Methods: This retrospective study included twenty eyes of 19 patients, mean age 59. Read More

J Chin Med Assoc 2019 Dec;82(12):935-940

Department of Pathophysiology, Faculty of Medical Sciences, University of Kragujevac, Serbia and The Balkans Scientific Center of the Russian Academy of Natural Sciences, Belgrade, Serbia.

Background: The purpose of this study is to reveal the participation of different regulatory cytokines within the process of pseudoexfoliation (PEX).

Methods: Our study included 140 patients referred to cataract surgery with early and late stage of pseudoexfoliation syndrome (XFS) or pseudoexfoliation glaucoma (XFG). Humor and serum levels of cytokines: transforming growth factor beta (TGF-β), platelet-derived growth factor (PDGF), epidermal growth factor (EGF), insulin-like growth factor (IGF), IL-8 and interferon-inducible T cell alpha chemoattractant (ITAC) were measured in a sample using high sensitivity enzyme-linked immunoabsorbent assay (ELISA) kit. Read More

Acta Ophthalmol 2020 Jun 26;98(4):337-342. Epub 2019 Nov 26.

Department of Ophthalmology, Oslo University Hospital, Oslo, Norway.

Purpose: To compare the corneal endothelial cell density (ECD) before and after cataract surgery in patients with and without pseudoexfoliation syndrome (PEX).

Methods: In this prospective study, we compared the ECD in 62 PEX patients with 62 patients without PEX (controls). The mean age was 78. Read More

Curr Eye Res 2020 Jul 29;45(7):805-813. Epub 2019 Nov 29.

Department of Ophthalmology, Gülhane Training and Research Hospital, University of Health Sciences , Ankara, Turkey.

Purpose: Pseudoexfoliation syndrome (PEX) is an age-related disorder of the extracellular matrix characterized by the accumulation of fibrillary deposits in the anterior chamber of the eye, which leads to the development of pseudoexfoliative glaucoma (PEG). Early identification of subjects with higher susceptibility to PEX and PEG development is very important so that these conditions are managed at earlier stages, which requires that an objective biomarker is defined. Therefore, in the present study, we aimed to determine if aqueous humor and tear fluid concentrations of clusterin, an extracellular chaperone, are objective biomarkers for PEX and PEG risk. Read More

Curr Opin Ophthalmol 2020 Jan;31(1):33-42

Private Practice, Gdańsk, Poland.

Purpose Of Review: Cataract surgery is the most common surgical procedure performed worldwide. Small pupils have been an eternal challenge for cataract surgeons; insufficient pupil dilation is associated with increased complication rates, including capsule rupture, vitreous loss, iris trauma or postoperative inflammation. The aim of the current review is to present the methods for pupil dilation and the risk factors for a small pupil in a cataract patient. Read More

Am J Ophthalmol 2020 03 13;211:105-113. Epub 2019 Nov 13.

Department of Ophthalmology, Seoul St Mary's Hospital, College of Medicine, Catholic University of Korea, Seoul, Republic of Korea. Electronic address:

Purpose: To assess the incidence and risk factors related to choroidal detachment after glaucoma drainage device (Ahmed valve) implantation.

Design: Retrospective case-control study.

Methods: A total of 188 eyes of 188 glaucoma patients were enrolled who underwent Ahmed valve implantation surgery. Read More

J Chin Med Assoc 2019 Oct 14. Epub 2019 Oct 14.

Department of Pathophysiology, Faculty of Medical Sciences, University of Kragujevac, Serbia and The Balkans Scientific Center of the Russian Academy of Natural Sciences, Belgrade, Serbia.

Background: The purpose of this study is to reveal the participation of different regulatory cytokines within the process of pseudoexfoliation (PEX).

Methods: Our study included 140 patients referred to cataract surgery with early and late stage of pseudoexfoliation syndrome (XFS) or pseudoexfoliation glaucoma (XFG). Humor and serum levels of cytokines TGF-β, PDGF, EGF, IGF, IL-8 and ITAC were measured in a sample using high sensitivity enzyme-linked immunoabsorbent assay (ELISA) kit. Read More

Exp Eye Res 2019 12 15;189:107837. Epub 2019 Oct 15.

Department of Ophthalmology, Gülhane Training and Research Hospital, University of Health Sciences, Ankara, Turkey.

Pseudoexfoliation syndrome (PEX) may lead to the development of pseudoexfoliative glaucoma (PEG), a potential cause of irreversible blindness, if left untreated. This type of glaucoma often presents with much higher intraocular pressure (IOP) values than observed in primary open angle glaucoma, and patients are often unaware of their condition. Therefore, early diagnosis is of utmost importance in PEX and PEG. Read More

Zh Nevrol Psikhiatr Im S S Korsakova 2019 ;119(9):17-22

Helmholtz National Medical Research Center of Eye Diseases, Moscow, Russia.

Aim: To compare the frequency of age-related ophthalmic diseases in patients with Alzheimer's disease and vascular dementia.

Material And Methods: The study included 60 patients with severe cognitive impairment divided into two equal groups matched for sex and age. The first group included patients diagnosed with Alzheimer's disease. Read More