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Am J Ophthalmol Case Rep 2019 Jun 25;14:1-4. Epub 2019 Jan 25.

Department of Ophthalmology and Visual Science, Graduate School of Biomedical Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima City, Hiroshima, 734-8551, Japan.

Purpose: Sympathetic ophthalmia (SO) is an autoimmune, bilateral, granulomatous panuveitis, which occurs following penetrating eye injury or eye surgery. We report two cases of refractory SO in patients with a history of trabeculectomy, which were treated effectively with adalimumab.

Observations: Case 1: A 69-year-old male with a history of trabeculectomy for rubeotic glaucoma of the right eye, secondary to diabetic retinopathy 8 years prior, presented with a decrease in visual acuity of the left eye due to SO. Read More

Klin Monbl Augenheilkd 2019 Feb 14;236(2):145-149. Epub 2019 Feb 14.

Institut für Kreislaufforschung und Sportmedizin, Deutsche Sporthochschule Köln.

Neuronal blood pressure control is mediated by the autonomic nervous system. In this article, physiological and pathophysiological mechanisms will be recapitulated. Blood pressure regulation aims at maintaining adequate cardiac output and a sufficient perfusion pressure for the organs. Read More

Klin Monbl Augenheilkd 2019 Feb 14;236(2):142-144. Epub 2019 Feb 14.

Augenklinik, Kantonsspital Aarau, Schweiz.

Normal tension glaucoma is a variant of primary open angle glaucoma. It is characterized by normal intraocular pressure. Although there are several pathophysiological explanations (e. Read More

Am J Ophthalmol 2019 Feb 11. Epub 2019 Feb 11.

Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, 243 Charles Street, Boston, MA 02114. Electronic address:

Purpose: To provide evidence that corticosteroid-induced ocular hypertension has a genetic component.

Design: Evidence-based Perspective.

Methods: We conducted a comprehensive literature search for studies exploring genetic influences on intraocular pressure responses to corticosteroid treatment. Read More

Graefes Arch Clin Exp Ophthalmol 2019 Feb 13. Epub 2019 Feb 13.

Department of Ophthalmology, University Hospitals UZ Leuven, Leuven, Belgium.

Purpose: To evaluate the effectiveness of an ab interno subconjunctival gelatin implant as primary surgical intervention in reducing intraocular pressure (IOP) and IOP-lowering medication count in medically uncontrolled moderate primary open-angle glaucoma (POAG).

Methods: In this prospective, non-randomized, open-label, multicenter, 2-year study, eyes with medicated baseline IOP 18-33 mmHg on 1-4 topical medications were implanted with (phaco + implant) or without (implant alone) phacoemulsification. Changes in mean IOP and medication count at months 12 (primary outcomes) and 24, clinical success rate (eyes [%] achieving ≥ 20% IOP reduction from baseline on the same or fewer medications without glaucoma-related secondary surgical intervention), intraoperative complications, and postoperative adverse events were assessed. Read More

J Ocul Pharmacol Ther 2019 Feb 13. Epub 2019 Feb 13.

Department of Ophthalmology, Faculty of Medicine, Yuzuncu Yil University, Van, Turkey.

Purpose: To determine the effects of antiglaucomatous drops on the conjunctival thickness.

Methods: Between March 2018 and May 2018, conjunctival thicknesses (epithelium + stroma) were measured with anterior segment OCT in 51 eyes of the control group and 49 eyes who had glaucoma diagnosis at the Van YYU Medical Faculty Ophthalmology Department and had been using antiglaucomatous drops for at least 6 months. At 12 o'clock direction, horizontal multisections were taken aiming at the conjunctiva 3-5 mm away from the limbus. Read More

Restor Neurol Neurosci 2019 Feb 5. Epub 2019 Feb 5.

Department of Ophthalmology, University of Basel, Basel, Switzerland.

Background: It is still debatable whether visual field defects in glaucoma have a reversible component and to what extent a temporary loss can be provoked.

Objective: To investigate the response of the visual function to a cold provocation in glaucoma patients, particularly to test whether subjects with Flammer syndrome (FS) behaved differently from subjects without FS.

Methods: Ten (10) primary open-angle glaucoma (POAG) patients with FS, 7 POAG patients without FS, and 11 healthy controls were tested with program G2 on the Octopus 101 perimeter before and after putting one hand in cold water (4°C) for 2 min. Read More

Graefes Arch Clin Exp Ophthalmol 2019 Feb 9. Epub 2019 Feb 9.

Eye Center, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany.

Background: The minimally invasive ab-interno trabeculectomy (AIT) via electro-ablation with the Trabectome has been on the European market since 2009. Many studies have proven the safety and efficacy of the procedure. Up until now, studies investigating the long-term effect of AIT have been sparse. Read More

BMC Ophthalmol 2019 Feb 6;19(1):46. Epub 2019 Feb 6.

Affiliated Eye Hospital, School of Ophthalmology and Optometry, Wenzhou Medical University, Zhejiang, China.

Background: To investigate the occurrence of ciliochoroidal detachment (CCD), its risk factors and its impact on the success rate after Ahmed glaucoma valve (AGV) implantation.

Methods: This is a retrospective observational study carried out at Eye Hospital of Wenzhou Medical University, Zhejiang, China. Patients with uncontrolled glaucoma who underwent AGV implantation alone or combined with phacoemulsification (AGV-Phaco) in the hospital from April 1, 2013 to July 31, 2016 were included. Read More

Klin Monbl Augenheilkd 2019 Feb 8. Epub 2019 Feb 8.

IMISE, Institut für Medizinische Informatik, Statistik und Epidemiologie, Leipzig.

Background: In glaucoma, progressive retinal nerve fibre loss can be measured in the peripapillary and macular regions using optical coherence tomography (OCT). The goal of this study was to evaluate the impact of glaucoma on all measureable retinal layers using the spectral domain OCT (SD-OCT).

Materials And Methods: SD-OCT scans using automated retinal layer segmentation were performed in both eyes of primary open-angle glaucoma patients with strictly monocular absolute visual field scotoma in the central 10° of their visual field. Read More

Ophthalmic Genet 2019 Feb 7:1-3. Epub 2019 Feb 7.

a Department of Ophthalmology, Glaucoma Research Chair, College of Medicine , King Saud University , Riyadh , Saudi Arabia.

BMC Ophthalmol 2019 Feb 6;19(1):45. Epub 2019 Feb 6.

Ophthalmology Department, Zagazig University, Zagazig, 44511, Egypt.

Background: To study the efficacy of the biodegradable collagen implant Ologen® as an adjuvant in phaco-viscocanalostomy in patients with coexisting cataract and primary open angle glaucoma.

Methods: This prospective, interventional, randomized clinical study was done at Alpha Vision Center, Zagazig, Egypt. Patients with coexisting cataract and glaucoma were randomized to receive either phaco-viscocanalostomy (Phacovisco group) (39 eyes) or phaco-viscocanalostomy with Ologen® implant (OloPhacovisco group) (40 eyes). Read More

Int Ophthalmol 2019 Feb 6. Epub 2019 Feb 6.

Department of Optometry, School of Rehabilitation Science, Iran University of Medical Sciences, Tehran, Iran.

Purpose: To evaluate discrete wavelet transform coefficients and identify descriptors of pattern electroretinogram (PERG) waveforms in order to determine PERG characteristics for optimizing the diagnosis of early primary open-angle glaucoma (POAG).

Methods: Pattern electroretinogram was performed in 30 normal eyes and 30 eyes with primary open-angle glaucoma according to the ISCEV protocol. The check size was 0. Read More

Vestn Oftalmol 2018 ;134(6):53-58

Orenburg State Medical University, Ministry of Health, 6 Sovetskaya St., Orenburg, Russian Federation, 460000.

Purpose: To determine the relationships between the changes in functional parameters of vision that occur in primary open-angle glaucoma (POAG) patients on neuroprotective therapy.

Material And Methods: The study included 146 patients with stages I-III POAG aged 40 to 85 years. The patients were randomly divided into the study group and the control group at 2:1 ratio. Read More

Vestn Oftalmol 2018 ;134(6):46-52

Excimer Ophthalmologic Clinic, 3/1 Marksistskaya St., Moscow, Russian Federation, 109147.

At present, implantation of multifocal IOLs in patients with primary open-angle glaucoma (POAG) remains questionable.

Purpose: To comparatively analyze the clinical and functional effectiveness of bifocal IOLs implanted during combined cataract and glaucoma surgery.

Material And Methods: The prospective study included 41 patients (75 eyes) with presbyopia and POAG who underwent one-stage cataract phacoemulsification with implantation of a multifocal IOL and non-penetrating deep sclerectomy (NPDS) with lens capsule. Read More

Med Sci Monit 2019 Feb 5;25:1001-1008. Epub 2019 Feb 5.

Department of Psychiatry, Collegium Medicum, Nicolaus Copernicus University, Bydgoszcz, Poland.

BACKGROUND The aim of this study was to assess and compare peripapillary retinal nerve fiber layer (RNFL) thickness in patients with Alzheimer's disease (AD), primary open-angle glaucoma (POAG), preperimetric glaucoma (PPG), and healthy controls with the use of Spectral Domain Optical Coherence Tomography (SD-OCT). MATERIAL AND METHODS Thirty patients with AD, 30 patients with POAG, 30 patients with PPG, and 30 healthy controls were enrolled in this cross-sectional study. Only 1 randomly selected eye of each patient was analyzed. Read More

Eur J Pharmacol 2019 Feb 1. Epub 2019 Feb 1.

International Medical University, IMU Clinical School, Seremban, Malaysia.

Ocular hypertension is believed to be involved in the etiology of primary open-angle glaucoma. Although many pharmaceutical agents have been shown to be effective for the reduction of intraocular pressure (IOP), a significant opportunity to improve glaucoma treatments remains. Thus, the aims of the present study were: (1) to evaluate the IOP-lowering effect of four compounds RU-551, RU-555, RU-839 (pyrimido[1,2-a]benzimidazole), and RU-615 (imidazo[1,2-a]benzimidazole) on steroid-induced ocular hypertension in rats after single drop and chronic applications; and (2) to test in silico and in vitro conventional rho-associated kinase (ROCK) inhibitory activity of the selected compound. Read More

Mol Vis 2018 31;24:890-901. Epub 2018 Dec 31.

Department of Biology, University of Patras, Patras, Greece.

Purpose: The aim of this study is to investigate the age-correlation of oxidative stress (OS, assessed by the accumulative OS damage marker protein carbonyls) in aqueous humour (AH; together with protein concentration) and lens epithelial cells plus capsule (LECs/capsule) in patients with cataract (CAT), and also suffering from pseudoexfoliation syndrome (PEX), primary open-angle glaucoma (POAG) and pseudoexfoliation glaucoma (PXG).

Methods: AH samples from 78 male/female patients (21, 20, 19 and 18 with CAT, PEX, PXG, and POAG, respectively), and LECs/capsule samples from 104 male/female patients (34, 32, 18, and 20 with CAT, PEX, PXG and POAG, respectively) were collected during phacoemulsification CAT surgery. Average protein carbonyl concentrations were measured in patients grouped in 5-year age intervals (ranging from 56-60 to 86-90). Read More

Curr Eye Res 2019 Feb 1. Epub 2019 Feb 1.

c Department of Biochemistry , Inonu University School of Medicine , Malatya , Turkey.

Purpose: To evaluate the asymmetric dimethylarginine (ADMA), symmetric dimethylarginine (SDMA) and L-arginine (L-Arg) levels both in plasma and aqueous humor of primary open angle glaucoma (POAG) patients and matched controls.

Patients And Methods: 25 primary open angle glaucoma paients and 42 control cases with senile cataract were included in the study. Plasma and aqueous humor ADMA, SDMA and L-Arg levels of the participants were measured by using liquid chromatography-tandem mass spectrometry. Read More

Am J Ophthalmol 2019 Jan 28. Epub 2019 Jan 28.

Stein Eye Institute, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, USA. Electronic address:

Purpose: To test the hypothesis that cataract surgery slows the apparent rate of visual field (VF) decay in primary open-angle glaucoma patients compared with rates measured during cataract progression.

Design: Retrospective cohort study.

Methods: Consecutive open-angle glaucoma patients who underwent cataract surgery and who had ≥4 VFs and ≥3 years of follow-up before and after surgery were retrospectively reviewed. Read More

J Proteome Res 2019 Feb 11. Epub 2019 Feb 11.

Unité Mixte de Recherche MITOVASC, équipe Mitolab, Centre National de la Recherche Scientifique 6015, Institut National de la Santé et de la Recherche Médicale U1083 , Université d'Angers , Angers 49035 , France.

We compared the metabolomic profile of aqueous humor from patients with primary open-angle glaucoma (POAG; n = 26) with that of a group of age- and sex-matched non-POAG controls (n = 26), all participants undergoing cataract surgery. Supervised paired partial least-squares discriminant analysis showed good predictive performance for test sets with a median area under the receiver operating characteristic of 0.89 and a p-value of 0. Read More

J Glaucoma 2019 Feb;28(2):172-177

Department of Ophthalmology and Visual Sciences, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan.

Purpose: We evaluated the agreement between the intraocular pressure (IOP) values of new rebound tonometer, Icare ic100, and Icare TA01i or Goldmann applanation tonometer (GAT).

Methods: We studied one eye each of 106 subjects (57 with primary open-angle glaucoma, 49 healthy subjects). IOP was randomly measured twice with the patient in sitting position using the Icare ic100, Icare TA01i, and GAT. Read More

J Glaucoma 2019 Feb;28(2):e36

Department of OphthalmologyKorea University College of Medicine Seoul, Korea.

J Glaucoma 2019 Feb;28(2):119-124

Department of Ophthalmology, University of Colorado Eye Center, Aurora, CO.

Purpose: The purpose of the study was to evaluate the tolerability and functionality of a wireless ocular telemetry sensor in African American patients with glaucoma.

Materials And Methods: In this prospective, observational cohort study, 20 African American patients with primary open angle glaucoma (POAG) were evaluated at the University of Colorado Eye Center. Before lens placement, patients recorded ocular comfort and underwent a baseline eye exam. Read More

BMJ Open Ophthalmol 2018 22;3(1):e000183. Epub 2018 Dec 22.

Department of Ophthalmology, New York Eye and Ear Infirmary of Mount Sinai, New York, USA.

Objective: To describe the safety and effectiveness of CyPass supraciliary microstent implantation alone in eyes with open-angle glaucoma (OAG) followed up for up to 3 years.

Methods And Analysis: This registry study included subjects with primary or secondary OAG who underwent CyPass Micro-Stent implantation alone at 12 sites in four European countries to reduce intraocular pressure (IOP) and/or use of IOP-lowering medications. The primary safety outcome was the incidence of adverse events. Read More

Am J Ophthalmol 2019 Jan 24. Epub 2019 Jan 24.

Guwahati, India.

J Fr Ophtalmol 2019 Feb 22;42(2):e37-e46. Epub 2019 Jan 22.

Service d'ophtalmologie, centre hospitalier national d'ophtalmologie des Quinze-Vingts, IHU ForeSight, , 28, rue de Charenton, 75012 Paris, France; Service d'ophtalmologie, hôpital Ambroise-Paré, université de Versailles Saint-Quentin-en-Yvelines, AP-HP, 9, avenue Charles-De-Gaulle, 92100 Boulogne-Billancourt, France; Inserm, U968, université UPMC Paris VI, UMR S 968, institut de la vision, CNRS, UMR 7210, 75012 Paris, France. Electronic address:

Purpose: The purpose of this study was to analyze the change in intraocular pressure (IOP) and glaucoma medications using the XEN Gel Stent as a solo procedure or in association with phacoemulsification in patients with chronic open angle glaucoma (OAG).

Methods: We included cohort studies with at least one year of follow-up in patients with primary open angle glaucoma (POAG), pseudo-exfoliative glaucoma (PXG) or pigmentary glaucoma (PG) who received a XEN gel stent. The main outcome measure was IOP reduction at 12 months follow-up. Read More

Am J Ophthalmol 2019 Jan 22. Epub 2019 Jan 22.

Rochester, Minnesota, USA.

Medicine (Baltimore) 2019 Jan;98(4):e14128

Graduate Institute of Biomedical Sciences and School of Medicine, College of Medicine.

To determine whether cataract or glaucoma and combined cataract and glaucoma surgery (CGS) affect glaucoma medication usage.We recruited patients who received new diagnoses of glaucoma, either primary open-angle glaucoma (POAG) (International Classification of Diseases, Ninth Revision, Clinical Modification [ICD-9-CM] code 365.1) or primary angle-closure glaucoma (PACG) (ICD-9-CM code 365. Read More

Nutrients 2019 Jan 22;11(2). Epub 2019 Jan 22.

Eye Clinic, Department of Neuroscience and Sensory Organs, University of Genoa, Policlinico San Martino Hospital IRCCS Hospital-University San Martino, Viale Benedetto XV, 16132 Genoa, Italy.

Glaucoma is a multifactorial disease in which pro-apoptotic signals are directed to retinal ganglion cells. During this disease the conventional outflow pathway becomes malfunctioning. Aqueous humour builds up in the anterior chamber, leading to increased intraocular pressure. Read More

Am J Pathol 2019 Jan 21. Epub 2019 Jan 21.

Department of Ophthalmology, the Second Xiangya Hospital, Central South University, Hunan Province, China; Hunan clinical research center of ophthalmic disease, Changsha, Hunan, China. Electronic address:

This study aimed to identify potential biomarkers for primary open-angle glaucoma (POAG) diagnosis. First, lncRNA and message RNA (mRNA) expression profiles in the aqueous humor (AH) from 10 POAG and 10 control patients were accessed by microarray analyses. Moreover, coding-non-coding gene co-expression networks were drawn to predict potential lncRNA functions. Read More

J Glaucoma 2018 Nov 30. Epub 2018 Nov 30.

Department of Anterior Segment and Refractive Surgery, Fondation Rothschild, Paris, France.

Purpose: To report a case of recurrent conjunctival erosion and XEN Gel Stent exposure after implantation in a primary open-angle glaucoma patient. Minimally invasive glaucoma surgery (MIGS) is a new approach in glaucoma surgery and there is a lack of published data regarding management of postoperative ocular surface complications.

Methods: Case report of a patient with a persistent corneal erosion after XEN Gel Stent implantation. Read More

J Glaucoma 2019 Jan 22. Epub 2019 Jan 22.

Department of Ophthalmology, William Beaumont Hospital, Royal Oak, MI, USA.

Purpose: To report 4 previously undescribed postoperative complications in 4 cases of ab-interno XEN45 Gel Stent (XEN) implantation following uncomplicated surgeries.

Patients And Methods: A total of 51 consecutive XEN implantations performed between July 1, 2017 and April 30, 2018 were reviewed. All cases were performed by 7 experienced glaucoma surgeons affiliated with the William Beaumont Hospital Department of Ophthalmology. Read More

J Glaucoma 2019 Jan 22. Epub 2019 Jan 22.

Department of Ophthalmology, Korea University College of Medicine, Seoul, Korea.

J Glaucoma 2019 Jan 22. Epub 2019 Jan 22.

Department of Ophthalmology, Hospital Universitario Ramón y Cajal. Carretera de Colmenar Km 9,1. 28034 Madrid (SPAIN).

Diabetes Metab Syndr Obes 2019 14;12:131-137. Epub 2019 Jan 14.

Department of Family Medicine, Research Institute of Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan 626-780, Korea,

Background: High intraocular pressure (IOP) is well established as the most significant risk factor for both the development and progression of primary open-angle glaucoma. Elevated IOP is more frequently seen in the presence of metabolic disturbances that are associated with the components of metabolic syndrome (MetS). The aim of this study was to investigate the association between ocular hypertension and MetS. Read More

Clin Ophthalmol 2019 11;13:161-168. Epub 2019 Jan 11.

University of Oklahoma, Oklahoma City, OK, USA.

Purpose: The purpose of this study was to evaluate the safety and efficacy of microinvasive glaucoma surgery (MIGS) with 360° ab-interno trabeculotomy using the TRAB360 device as a stand-alone procedure in patients with refractory primary open-angle glaucoma (POAG) and preoperative IOP ≥18 mmHg.

Setting: This study evaluated patients treated in a tertiary-referral clinical practice setting.

Design: This study is a retrospective analysis of 81 eyes. Read More

Chronobiol Int 2019 Jan 21:1-14. Epub 2019 Jan 21.

g Institute of Biology/Zoology , Martin Luther University , Halle-Wittenberg , Germany.

Advanced primary open-angle glaucoma (POAG) is characterized by progressive retinal ganglion cell complex (RGCC) damage that may cause subsequent disruption of the circadian rhythms. Therefore, we evaluated circadian body temperature (BT) rhythm and sleep characteristics of 115 individuals (38 men and 77 women) diagnosed with POAG. GLV (global loss volume; %), a measure of RGCC damage, was estimated by high-definition optical coherence tomography, and RGC functional ability was assessed by pattern electroretinogram amplitude (PERGA). Read More

Acta Ophthalmol 2019 Jan 17. Epub 2019 Jan 17.

Department of Ophthalmology, Chungnam National University Hospital, Deajeon, Korea.

Purpose: To assess influence of the location of visual field (VF) loss on vision-related quality of life (VRQOL) in patients with glaucoma.

Methods: We included 826 patients with primary open-angle glaucoma (POAG) enrolled in the prospectively designed Life Quality of Glaucoma Patients Who Underwent Treatment (LIGHT) study organized by the Korean Glaucoma Society. We divided the integrated binocular visual field (IVF) into four regions and evaluated the associations between Rasch-analysed 25-item National Eye Institute Visual Function Questionnaire (NEI VFQ-25) and location of the IVF using univariate and hierarchical multivariable linear regression. Read More

Exp Eye Res 2019 Jan 15;181:85-89. Epub 2019 Jan 15.

Scheie Eye Institute, University of Pennsylvania, Philadelphia, PA, USA. Electronic address:

Mitochondrial dysfunction has been implicated in the pathogenesis of primary open-angle glaucoma (POAG). However, the potential significance of mitochondrial DNA (mtDNA) haplogroups to POAG has not been evaluated in the overaffected African American population. To investigate the association of mtDNA haplogroups with POAG and its phenotypic characteristics, genotyping data from 4081 African American subjects (1919 cases and 2162 controls) was analyzed using 1293 positions on mtDNA. Read More

Acta Cardiol 2019 Jan 16:1-5. Epub 2019 Jan 16.

a Cardiology Department , Baskent University Faculty of Medicine , Ankara , Turkey.

Background: Glaucoma is commonly defined as high intra ocular pressure (≥21 mmHg) with optic neuropathy characterised by progressive loss of retinal ganglion cells which is associated with characteristic structural damage to the optic nerve and visual field loss. There are several studies investigating relation between primary open angle glaucoma (POAG) and both systemic hypertension and especially night hypotension. Our aim was to compare 24-h ambulatory blood pressure variability of patients with glaucoma followed-up in the eye outpatient clinic with that of patients free of glaucoma. Read More

J Ophthalmol 2018 13;2018:7474086. Epub 2018 Dec 13.

Department of Ophthalmology, Affiliated Hospital of Qingdao University, Qingdao, China.

Objective: A prospective study was performed to observe the effects of nonsteroidal anti-inflammatory drug (NSAID) eyedrops on intraocular pressure (IOP) and the ocular surface in primary open-angle glaucoma (POAG) patients treated with 0.005% latanoprost eyedrops.

Methods: Forty-eight subjects were randomized into two study groups (NSAID and control). Read More

Curr Pharm Des 2019 Jan 15. Epub 2019 Jan 15.

Chronic Diseases Research Unit, Department of Medical Technology, Faculty of Allied Health Sciences, Naresuan University, Naresuan University, 99 Moo 9 Tambon Tha Pho, Muang Phitsanulok 65000. Thailand.

Background: Oxidative stress, an increased free radicals or oxidant productions result in cellular degeneration and neurodegeneration by damage all macromolecules, inducing lipid peroxidation, protein modification, DNA damage and apoptosis or cell death.

Methods: Accumulation of the DNA damage (8HOdG) products and the end products of LPO (including aldehyde, diene, triene conjugates and Schiff's bases) were noted in the research studies. Significant higher in the levels of these products in comparison with the control were observed. Read More

Graefes Arch Clin Exp Ophthalmol 2019 Jan 15. Epub 2019 Jan 15.

Glaucoma Research Center, Wills Eye Hospital, 840 Walnut Street, Suite 1140, Philadelphia, PA, 19107, USA.

Primary open-angle glaucoma is currently characterized by a pattern of progressive retinal ganglion cell loss that stems from a complex underlying pathophysiology that remains poorly elucidated. The roles of blood flow and intraocular pressure (IOP) in glaucoma pathogenesis have been extensively studied. Further, it has been established that lowering IOP can slow the progression of glaucoma. Read More

Clin Ophthalmol 2019 27;13:33-42. Epub 2018 Dec 27.

IOBA-Eye Institute, Universidad de Valladolid, Valladolid, Spain,

Purpose: The purpose of this study was to develop an objective algorithm to discriminate the earliest stages of glaucoma using frequency doubling technology (FDT) Matrix perimetry and spectral domain-optical coherence tomography (OCT) technology to improve primary care detection.

Materials And Methods: Three hundred six eyes (mean age 58.67±15. Read More

Invest Ophthalmol Vis Sci 2019 Jan;60(1):161-167

Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India.

Purpose: To compare the distribution of visual field progression rates in three subgroups of glaucoma, being primary angle-closure glaucoma (PACG), POAG, and juvenile open-angle glaucoma (JOAG).

Methods: We assessed glaucoma patients treated in an Indian tertiary care setting with at least four visual field assessments. We determined rates from a single eye of each of 525 patients using linear regression of the summary index mean deviation (MD) over time. Read More

Doc Ophthalmol 2019 Feb 12;138(1):21-33. Epub 2019 Jan 12.

Department of Retina, Shri Bhagwan Mahavir Vitreoretinal Services, Sankara Nethralaya, Medical Research Foundation, 18 College Road, Nungambakkam, Chennai, 600 006, India.

Purpose: A prospective, cross-sectional, case-control study was conducted to investigate the role of broadband and monochromatic photopic negative response (PhNR) of the full-field flash electroretinogram (ERG) in the evaluation of ganglion cell damage in primary open-angle glaucoma (POAG) subjects.

Methods: Subjects with POAG and age-matched normal subjects were recruited from the outpatient department of a tertiary eye care center in South India. A total of 25 patients with POAG and 50 age-matched normal subjects were recruited. Read More

Eye (Lond) 2019 Jan 11. Epub 2019 Jan 11.

Scheie Eye Institute, University of Pennsylvania, Philadelphia, PA, USA.

Objective: To introduce a new method of grading optic nerve stereo disc photographs and evaluate reproducibility of assessments by non-physician graders in a reading center.

Methods: Three non-physician graders, experienced in grading features of the retina but not the optic nerve head (ONH), were trained by glaucoma specialists to assess digital stereo color images of the ONH. These graders assessed a total of 2554 digital stereo disc images from glaucoma cases and controls participating in the Primary Open-Angle African American Glaucoma Genetics (POAAGG) study by outlining the optic cup and disc. Read More

Am J Ophthalmol 2019 Jan 8. Epub 2019 Jan 8.

Department of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, MI; Center for Eye Policy and Innovation, University of Michigan, Ann Arbor, MI; Department of Health Management and Policy, University of Michigan School of Public Health, Ann Arbor, MI. Electronic address:

Purpose: To characterize differences in resource utilization and cost of managing enrollees with exfoliation glaucoma (XFG) compared to primary open-angle glaucoma (POAG).

Design: Retrospective utilization and cost comparison using Medicare claims data.

Methods: We identified Medicare beneficiaries with XFG or POAG and ≥5 years of continuous enrollment from January 2008 to December 2014. Read More

J Glaucoma 2019 Jan 7. Epub 2019 Jan 7.

Department of Ophthalmology, University Medical Center Mainz, Mainz, Germany.

Purpose: To examine vessel density (VD) properties of the optic nerve head (ONH) in eyes with ocular hypertension (OHT), high-tension glaucoma (HTG) and normal-tension glaucoma (NTG) and to evaluate associations on structural parameters of retinal nerve fiber layer (RNFL).

Methods: Three groups of patients with OHT (n=15), HTG (n=36) and NTG (n=22), and a healthy control group (n=23) were included in this study. Peripapillary VD and optic disc flow area were measured using optical coherence tomography angiography, and peripapillary RNFL thickness was determined. Read More