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Semin Ophthalmol 2022 Jul 1:1-5. Epub 2022 Jul 1.

Glaucoma Services, L V Prasad Eye Institute, Visakhapatnam, India.

Purpose: To systematically review surgical procedure, safety and efficacy of Gonioscopy-Assisted Transluminal Trabeculotomy (GATT).

Methods: A review of literature was done to analyze all suitable articles from two different databases.

Results: GATT is effective in reducing intraocular pressure and mean number of medications from baseline. Read More

Ophthalmol Ther 2022 Jun 30. Epub 2022 Jun 30.

Eye Center of the Second Affiliated Hospital, School of Medicine, Zhejiang University, No. 1 Xihu Boulevard, Hangzhou, 310009, Zhejiang, China.

Introduction: To compare 1-year outcomes of CO laser-assisted sclerectomy surgery (CLASS) alone or combined with phacoemulsification (CLASS + Phaco) in eyes with primary open-angle glaucoma (POAG).

Methods: This was a prospective, comparative, case series study. A total of 46 eyes with POAG underwent CLASS or CLASS + Phaco were followed up for 1 year. Read More

Sci Rep 2022 Jun 30;12(1):11070. Epub 2022 Jun 30.

Department of Ophthalmology & Visual Science, Eye & ENT Hospital, Shanghai Medical College, Fudan University, 83 Fenyang Road, Shanghai, 200031, China.

The ophthalmoscopic beta zone of parapapillary atrophy has recently been proposed to divide into a gamma zone and a (new) beta zone based on OCT imaging. The present study was undertaken to compare the microstructural characteristics of parapapillary gamma and beta zones and their influencing factors between primary open angle glaucoma (POAG) and primary angle closure glaucoma (PACG). Seventy-three PACG patients that had no evidence of an acute attack and 78 POAG patients were enrolled. Read More

Psychiatr Danub 2022 ;34(2):348-355

Department of Ophthalmology, Zagreb University Hospital Center, Kišpatićeva 12, 10000 Zagreb, Croatia,

Background: The COVID-19 epidemic and earthquakes in Croatia during 2020 suddenly disrupted everyday life and caused psychological disturbances in population. The purpose of the present study was to assess the prevalence of anxiety symptoms and the level of treatment adherence in glaucoma patients during the pandemic. The paper also aimed to evaluate the correlation between anxiety symptoms, treatment adherence and treatment outcomes in the studied cohort. Read More

J Acupunct Meridian Stud 2021 Oct;14(5):193-199

Basic Science Department, Faculty of Physical Therapy, Cairo University, Giza, Egypt.

Background: Despite the adherence to medications, the control of the modifiable key risk factor-intraocular pressure (IOP)-for the progression of primary open-angle glaucoma (POAG) in diabetics is usually difficult; hence, many glaucoma patients try other alternative therapeutic options. Objectives: This randomized controlled study investigated the short-term IOP response to the combined effects of transcutaneous electrical nerve stimulation over acupoint (Acu-TENS) and yoga ocular exercise in type 2 diabetics with POAG.

Methods: Eighty diabetics with bilateral POAG, ages ≥ 50 years, IOP > 21 mmHg in both eyes, and a body mass index below 30 kg/m were included in this trial. Read More

Invest Ophthalmol Vis Sci 2022 Jun;63(6):29

Guangdong Eye Institute, Department of Ophthalmology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.

Purpose: To test for causality with regard to the association between blood pressure (BP) and intraocular pressure (IOP) and glaucoma.

Methods: Single nucleotide polymorphisms (SNPs) associated with BP were identified in a genome-wide association study (GWAS) meta-analysis of 526,001 participants of European ancestry. These SNPs were used to assess the BP versus IOP relationship in a distinct sample (n = 70,832) whose corneal-compensated IOP (IOPcc) was measured. Read More

J Glaucoma 2022 Jun 27. Epub 2022 Jun 27.

Sekuru Kaguvi Hospital Zimbabwe.

Purpose: To explore regional variations in the presentation of newly diagnosed glaucoma in Sub Saharan Africa (SSA).

Methodology: This was a multi-centre, cross-sectional study in which newly diagnosed, consecutive, glaucoma patients aged ≥18 years were recruited from 27 eye clinics in 10 countries throughout SSA. Demographic and ophthalmic examination data were collected. Read More

Clin Ophthalmol 2022 20;16:2011-2024. Epub 2022 Jun 20.

Department of Anesthesia and Surgical Intensive Care, Benha University Hospital, Benha, Qualubia, Egypt.

Objective: To assess the effect of peribulbar anesthesia on retinal microvasculature in primary open-angle glaucoma (POAG) patients undergoing cataract surgery using OCT Angiography.

Participants: Forty-nine patients undergoing cataract surgery were divided into two groups. Group I included patients with no history of glaucoma, while group II included patients previously diagnosed as POAG with controlled IOP. Read More

Eye (Lond) 2022 Jun 25. Epub 2022 Jun 25.

Glaucoma Division, Stein Eye Institute, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA, USA.

Background/objective: Management of concomitant cataract and glaucoma depends on the stage of glaucoma and the patient's situation. There are different surgical options for handling visually significant cataract and mild-to-moderate open-angle glaucoma (OAG). We aimed to compare the one-year results of phacoemulsification alone versus phacoviscocanalostomy in these patients. Read More

Ophthalmology 2022 Jun 22. Epub 2022 Jun 22.

Hamilton Glaucoma Center, Shiley Eye Institute, Viterbi Family Department of Ophthalmology, University of California San Diego, La Jolla, CA, United States. Electronic address:

Purpose: To investigate the effect of smoking on the rates of progressive visual field damage over time in glaucoma.

Design: Retrospective cohort study.

Participants: A total of 511 eyes of 354 patients with glaucoma followed from multicenter glaucoma registries. Read More

EClinicalMedicine 2022 Jul 8;49:101498. Epub 2022 Jun 8.

Yong Loo Lin School of Medicine, National University of Singapore, Singapore.

Background: Glaucoma and chronic kidney disease (CKD) are prevalent and debilitating conditions, with common pathogenic pathways like oxidative stress and fluid dysregulation. We evaluated if there is a bidirectional association between them, as previous studies have yielded conflicting results.

Methods: In this systematic review and meta-analysis, we searched PubMed, Embase and Cochrane Library from inception until 15 June 2021, including full-length English articles published in peer-reviewed journals reporting on glaucoma and CKD as either exposure or outcome, among participants aged ≥18 years. Read More

J Clin Med 2022 Jun 19;11(12). Epub 2022 Jun 19.

Department of Medicine and Health Sciences, "V. Tiberio", University of Molise, 86100 Campobasso, Italy.

This study aimed to evaluate whether the therapeutic switch from a formulation of Bimatoprost 0.1 mg/mL with benzalkonium chloride (BAK) or Bimatoprost 0.3 mg/mL preservative-free to a formulation of Bimatoprost 0. Read More

J Clin Med 2022 Jun 17;11(12). Epub 2022 Jun 17.

Glaucoma Institute of Beverly Hills, West Hollywood, CA 90048, USA.

Primary open-angle glaucoma (POAG) is currently treated with a variety of surgical and non-surgical approaches. Minimally invasive glaucoma surgery (MIGS) involves several devices and procedures that lower intraocular pressure (IOP) by increasing aqueous outflow. The first laser-based MIGS procedure, Excimer Laser Trabeculostomy (ELT), has emerged as a safe and effective treatment option. Read More

Genes (Basel) 2022 Jun 13;13(6). Epub 2022 Jun 13.

Department of Epidemiology, Unit of Genetic Epidemiology and Bioinformatics, University of Groningen, UMCG, Hanzeplein 1, 9713 GZ Groningen, The Netherlands.

Background: Primary open-angle glaucoma (POAG) is the most prevalent glaucoma subtype, but its exact etiology is still unknown. In this study, we aimed to prioritize the most likely 'causal' genes and identify functional characteristics and underlying biological pathways of POAG candidate genes.

Methods: We used the results of a large POAG genome-wide association analysis study from GERA and UK Biobank cohorts. Read More

Antioxidants (Basel) 2022 Jun 9;11(6). Epub 2022 Jun 9.

Department of Ophthalmology, Shimane University Faculty of Medicine, Izumo 693-8501, Japan.

Carotenoids have antioxidant properties, and the accumulation of advanced glycation end products (AGEs) is associated with reactive oxygen species production; they have attracted attention as factors predictive of the onset and progression in glaucoma. Fingertip measurement is applicable for carotenoids and AGEs due to its noninvasiveness and simplicity. The study included 663 eyes of 663 Japanese subjects (357 males, 306 females). Read More

Sci Rep 2022 Jun 23;12(1):10623. Epub 2022 Jun 23.

Doheny Eye Institute, Los Angeles, CA, USA.

Primary open angle glaucoma (POAG) features an optic neuropathy, elevated aqueous humor (AH) TGFβ2, and major risk factors of central corneal thickness (CCT), increasing age and intraocular pressure (IOP). We examined Tight skin (Tsk) mice to see if mutation of fibrillin-1, a repository for latent TGFβ, is associated with characteristics of human POAG. We measured: CCT by ocular coherence tomography (OCT); IOP; retinal ganglion cell (RGC) and optic nerve axon counts by microscopic techniques; visual electrophysiologic scotopic threshold responses (STR) and pattern electroretinogram (PERG); and AH TGFβ2 levels and activity by ELISA and MINK epithelial cell-based assays respectively. Read More

Vision (Basel) 2022 Jun 14;6(2). Epub 2022 Jun 14.

Department of Surgery, Division of Ophthalmology, Lahey Hospital & Medical Center, Beth Israel Lahey Health, Burlington, MA 01805, USA.

Seasonal affective disorder (SAD) is characterized by depressive episodes related to changes in the seasons. Patients with severe vision loss are at an increased risk of SAD. This study seeks to determine the extent to which patients with moderate vision loss report symptoms of SAD. Read More

Arq Bras Oftalmol 2022 May-Jun;85(3):327

Honorary professor, Dr DY Patil University, Pune, India.

J Am Geriatr Soc 2022 Jun 22. Epub 2022 Jun 22.

Department of Ophthalmology & Visual Sciences, University of Michigan Medical School, Ann Arbor, Michigan, USA.

Introduction: Prior studies on the association of glaucoma and cognitive function have reported mixed results.

Methods: The Health and Retirement Study (HRS) is a nationally representative panel survey of Americans age ≥ 51 years. HRS-linked Medicare claims data were used to identify incident glaucoma cases (by glaucoma type). Read More

Prog Retin Eye Res 2022 Jun 18:101094. Epub 2022 Jun 18.

Department of Physiology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA; Department of Ophthalmology, Dean A. McGee Eye Institute, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA. Electronic address:

Caveolae, specialized plasma membrane invaginations present in most cell types, play important roles in multiple cellular processes including cell signaling, lipid uptake and metabolism, endocytosis and mechanotransduction. They are found in almost all cell types but most abundant in endothelial cells, adipocytes and fibroblasts. Caveolin-1 (Cav1), the signature structural protein of caveolae was the first protein associated with caveolae, and in association with Cavin1/PTRF is required for caveolae formation. Read More

Br J Ophthalmol 2022 Jun 21. Epub 2022 Jun 21.

Department of Ophthalmology, Seoul National University Bundang Hospital, Seongnam, Republic of Korea

Background/aims: To investigate the influence of peripapillary retinoschisis (PRS) on visual field (VF) test results in patients with primary open angle glaucoma (POAG).

Methods: Thirty eyes of 30 patients with POAG who had PRS at least once were included. All eyes were followed-up for a minimum 5 years at 4-6-month intervals. Read More

Front Genet 2022 1;13:877174. Epub 2022 Jun 1.

Department of Ophthalmology, College of Medicine, King Saud University, Riyadh, Saudi Arabia.

It is plausible that common disease mechanisms exist in glaucoma pathophysiology. Accordingly, we investigated the genetic association of two previously reported primary open-angle glaucoma (POAG)-related gene polymorphisms, rs2472493 (A > G) in and rs7636836 (C > T) in FNDC3B, in primary angle-closure glaucoma (PACG) and pseudoexfoliation glaucoma (PXG). TaqMan genotyping was performed in a total of 442 subjects consisting of 246 healthy controls, 102 PACG patients, and 94 PXG patients. Read More

Ophthalmology 2022 Jun 16. Epub 2022 Jun 16.

VA Million Veteran Program consortium acknowledgement is provided in the appendix.

Purpose: Primary open-angle glaucoma (POAG) is a degenerative eye disease for which early treatment is critical to mitigate visual impairment and, in severe cases, irreversible blindness. POAG-associated loci individually confer incremental risk. Genetic risk score(s) (GRS) could enable POAG risk stratification. Read More

Clin Ophthalmol 2022 10;16:1925-1932. Epub 2022 Jun 10.

Department of Ophthalmology, University of Texas Southwestern Medical Center, Dallas, TX, USA.

Purpose/relevance: To determine the influence of hypertension (HTN), type 2 diabetes (DM2), migraine, and obstructive sleep apnea (OSA) on the onset of primary open-angle glaucoma (POAG) to enhance predictive accuracy.

Methods: In this cross-sectional study, data for 389 eligible patients with POAG were collected through medical records review and phone surveys. All data were assessed collectively using stepwise multiple regression analysis to determine the relative contribution to age at POAG diagnosis. Read More

Br J Ophthalmol 2022 Jun 14. Epub 2022 Jun 14.

Department of Ophthalmology, Otto von Guericke University, Magdeburg, Germany

Background: Patients with glaucoma on topical glaucoma medication are often affected by dry eye symptoms and thus likely to rub or squeeze their eyelids. Here, we telemetrically measure peak intraocular pressure (IOP) during eyelid manoeuvres and eyelid rubbing.

Methods: Eleven patients with primary open-angle glaucoma (POAG) previously implanted with a telemetric IOP sensor (Eyemate-IO) were instructed to look straight ahead for 1 min as a baseline measurement. Read More

J Glaucoma 2022 Jun 14. Epub 2022 Jun 14.

Hamilton Glaucoma Center, Shiley Eye Institute, Viterbi Family Department of Ophthalmology, University of California, San Diego, La Jolla, CA, United States.

Purpose: To compare the pattern of vascular density and structural damage in primary open angle glaucoma (POAG) with primary angle-closure glaucoma (PACG) using OCT and OCT angiography (OCTA) in the optic nerve head, circumpapillary, and macular regions.

Methods: One hundred and thirty-one eyes of 82 patients (53 eyes with PACG and 78 eyes with POAG) were enrolled into this study. Patients underwent complete ophthalmic examination, Bruch's membrane opening minimum rim width (BMO-MRW), circumpapillay retinal nerve fiber layer (cpRNFL), and macular ganglion cell complex (GCC) measurements and vascular density determination of the peripapillary and macular area with OCT and OCTA. Read More

Clin Ophthalmol 2022 7;16:1815-1819. Epub 2022 Jun 7.

Division of Ophthalmology, Matsue Red Cross Hospital, Matsue, Shimane, Japan.

Background: We report the real-world distribution of glaucoma types and glaucoma surgeries in each age or sex group in our department.

Methods: The department database of Matsue Red Cross Hospital, a tertiary care hospital, for eyes surgically treated to manage glaucoma between April 2014 and March 2018 was searched. Patient age, sex, disease type, and surgical procedure were collected from the database. Read More

J Glaucoma 2022 Jun 13. Epub 2022 Jun 13.

Gazi University School of Medicine, Department of Ophthalmology, Ankara, 06500, Turkey.

Prcis: Gonioscopy-assisted transluminal trabeculotomy (GATT) provides greater intraocular pressure (IOP) reduction in pseudoexfoliative glaucoma (PXG) than in primary open-angle glaucoma (POAG) in the first years of surgery; however, the difference between groups equalizes in the long-term.

Purpose: To compare outcomes of GATT in eyes with POAG and PXG.

Methods: Single-center, retrospective, comparative case series. Read More

Case Rep Ophthalmol Med 2022 2;2022:2343139. Epub 2022 Jun 2.

Glaucoma Services, Centre for Sight, B-5/24, Safdarjung Enclave, New Delhi, India.

Purpose: To describe a case of secondary acute angle closure glaucoma due to silicone oil migration into the posterior chamber causing entrapment of aqueous and its successful management. . A 69-year-old female presented with decreased vision and pain in the left eye (LE) for one month. Read More

Front Genet 2022 27;13:838220. Epub 2022 May 27.

Eye and ENT Hospital, College of Medicine, Eye Institute, Fudan University, Shanghai, China.

Glaucoma is the leading cause of irreversible blindness globally; hence, relevant clinical biomarkers are necessary to enable diagnosis, early detection, and development of novel therapies. The differentially expressed genes were annotated and visualized using Gene Ontology and Kyoto Encyclopedia. In addition, a competitive endogenous ribonucleic acids network was constructed using Cytoscape, which explained the regulation of gene expression in glaucoma. Read More