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Arch Soc Esp Oftalmol 2020 Jul 8. Epub 2020 Jul 8.

Servicio de Oftalmología, Hospital San Pedro, Logroño (La Rioja), España.

Case Report: A 68-year-old male with a cataract and uncontrolled primary open angle glaucoma with maximal tolerated medication underwent non-penetrating deep sclerectomy combined with phacoemulsification surgery in right eye. There were no complications during the procedure, but shortly after the surgery, he lost visual acuity after a Valsalva manoeuvre due to an endocapsular haematoma. Neodymium:YAG laser posterior capsulotomy was performed for the treatment of an unresolving endocapsular haemorrhage at the third month of the follow-up, with immediate visual improvement and optimal control of intraocular pressure. Read More

BMC Ophthalmol 2020 Jul 9;20(1):275. Epub 2020 Jul 9.

Post Marketing Surveillance Department, Kowa Co., Ltd., Tokyo, Japan.

Background: Ripasudil is approved in Japan for glaucoma or ocular hypertension (OH) when other treatments are ineffective or cannot be administered. Its long-term safety and efficacy are being examined in a post-marketing surveillance study; 12-month data are described here.

Methods: This prospective, open-label, observational study enrolled patients with glaucoma or OH who started ripasudil during routine care. Read More

Am J Ophthalmol Case Rep 2020 Sep 28;19:100800. Epub 2020 Jun 28.

Scheie Eye Institute, Department of Ophthalmology, University of Pennsylvania, 51 N. 39th Street, Philadelphia, PA, 19104, USA.

Purpose: To report 2 cases with a novel finding of bullous epithelial keratopathy associated with netarsudil use.

Observations: A 72-year-old man with history of primary open angle glaucoma was started on netarsudil daily in both eyes for uncontrolled intraocular pressures despite treatment with latanoprost, brimonidine, and dorzolamide-timolol. One month later he presented with bilateral conjunctival hyperemia, predominantly inferior corneal epithelial bullae, and keratic precipitates without hypopyon. Read More

Proc Inst Mech Eng H 2020 Jul 7:954411920934960. Epub 2020 Jul 7.

Department of Mechanical Engineering, Indian Institute of Technology Kanpur, Kanpur, India.

A numerical model of drug delivery from a therapeutic lens in the anterior portion of the human eye has been developed for a more effective treatment plan of primary open-angle glaucoma. The numerical model takes into account the drug diffusion through the therapeutic lens along with heat transfer and aqueous humor flow in different orientations of the human eye (supine (two-dimensional) as well as standing (three-dimensional)). Results illustrate that the drug diffuses through the therapeutic lens to the cornea and is convected into the anterior chamber of the eye due to the temperature gradient across the eye. Read More

Ophthalmol Glaucoma 2020 Jan-Feb;3(1):32-39. Epub 2019 Oct 4.

Legacy Devers Eye Institute, Portland, OR, United States.

Purpose: Ophthalmologists commonly perform glaucoma surgery to treat progressive glaucoma. Few studies have examined the stability of OCT neuroretinal rim parameters after glaucoma surgery for ongoing detection of glaucoma progression.

Design: Longitudinal cohort study. Read More

Ophthalmol Glaucoma 2020 Jan-Feb;3(1):7-13. Epub 2019 Nov 14.

Hamilton Glaucoma Center, Shiley Eye Institute, Department of Ophthalmology, University of California San Diego, La Jolla, CA.

Purpose: To compare the rates of retinal nerve fiber layer (RNFL) thinning after intraocular pressure (IOP) lowering procedures in eyes with or without disc hemorrhage (DH) history.

Design: Observational cohort study.

Methods: A total of 166 primary open angle glaucoma (POAG) eyes and glaucoma suspect eyes (37 eyes with DH history (DH group) and 129 eyes without DH (non-DH group)) were included from the African Decent and Glaucoma Evaluation Study (ADAGES) and the Diagnostic Innovations in Glaucoma Study (DIGS). Read More

PLoS One 2020 6;15(7):e0235571. Epub 2020 Jul 6.

Department of Sensory Organ Studies, Nicolaus Copernicus University, Collegium Medicum in Bydgoszcz, Bydgoszcz, Poland.

Purpose: To evaluate the correlation between retinal sensitivity in microperimetry (MP) with vessel density (VD) using optical coherence tomography angiography (OCTA) in primary open-angle glaucoma (POAG).

Methods: We enrolled 30 participants (52 eyes) with POAG and 15 participants (23 eyes) in the healthy control group. All participants were examined for retinal structure using OCTA to assess VD and Spectral domain OCT (SD-OCT) to assess ganglion cell complex (GCC) and peripapillary retinal nerve fiber layer (pRNFL) thickness. Read More

Mol Med Rep 2020 Aug 9;22(2):1103-1110. Epub 2020 Jun 9.

Department of Ophthalmology, University Hospital of Heraklion, 71110 Heraklion, Greece.

Glaucoma is a group of progressive optic neuropathies that have in common characteristic optic nerve head changes, loss of retinal ganglion cells and visual field defects. Among the large family of glaucomas, primary open‑angle glaucoma (POAG) is the most common type, a complex and heterogeneous disorder with environmental and genetic factors contributing to its pathogenesis. Approximately 5% of POAG is currently attributed to single‑gene or Mendelian forms of glaucoma. Read More

J Fr Ophtalmol 2020 Jul 1. Epub 2020 Jul 1.

Ophthalmology unit A, hôpital des spécialités, faculty of medicine and pharmacy, university Mohammed V, Rabat, Maroc.

Introduction: Behçet's disease is a systemic disease of unknown etiology. Its ocular manifestations are multiple and polymorphic, with uveitis at the top of the list. Classically, uveitis in Behçet's disease does not cause elevation of intraocular pressure. Read More

Invest Ophthalmol Vis Sci 2020 Jul;61(8)

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Purpose: Prior studies have demonstrated that microglial activation is involved in the pathogenesis of primary open-angle glaucoma (POAG). Here we sought to identify genetic associations between POAG and variants in APOE and TREM2, genes associated with Alzheimer disease (AD) that critically regulate microglial neurodegeneration-associated molecular signature.

Methods: APOE genotypes were called using imputed data from the NEIGHBOR consortium (2120 POAG cases, 2262 controls) and a second cohort from the Massachusetts Eye and Ear Infirmary (MEEI; 486 cases, 344 controls). Read More

Br J Ophthalmol 2020 Jul 1. Epub 2020 Jul 1.

Department of Ophthalmology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Korea.

Background/aims: To investigate whether parapapillary choroidal microvasculature dropout (MvD) is associated with progressive retinal nerve fibre layer (RNFL) thinning in eyes with primary open-angle glaucoma (POAG) and disc haemorrhage (DH).

Methods: Parapapillary microvasculature was evaluated by swept-source optical coherence tomography (OCT) angiography (OCTA) in 50 eyes with POAG and DH, 1 year before, at the time of and 1 year after the detection of DH. MvD was defined as an area in the parapapillary deep layer of focal sectoral dropout with no visible microvascular network. Read More

PLoS One 2020 1;15(7):e0235255. Epub 2020 Jul 1.

Department of Ophthalmology and Visual Sciences, University of Alabama at Birmingham, Birmingham, Alabama, United States of America.

Purpose: While many tests and indices are available to identify glaucoma progression, using them in combinations may decrease overall specificity. The aim of this study was to develop a framework for assessing glaucoma progression using structural and functional indices jointly for a fixed specificity.

Methods: The study included 337 eyes of 207 patients with ocular hypertension or primary open-angle glaucoma selected from the Diagnostic Innovations in Glaucoma Study or the African Descent and Glaucoma Evaluation Study. Read More

Mol Vis 2020 26;26:483-493. Epub 2020 Jun 26.

Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Augusta, GA.

Purpose: Schlemm's canal (SC) endothelial cells derived from donors with or without glaucoma showed different mechanical properties and gene expression. As an important contributor to the regulation of intraocular pressure (IOP) and pathogenesis of primary open-angle glaucoma (POAG), the heritable key epigenetic changes, methylation may play an important role in the physiologic function of SC cells. This study aims to identify differentially methylated CpG sites (DMSs) in primary cultures of human SC cells with or without glaucoma. Read More

Br J Ophthalmol 2020 Jun 30. Epub 2020 Jun 30.

School of Optometry and Vision Science, University of New South Wales, Sydney, Australia.

Currently, intraocular pressure is the only modifiable risk factor for glaucoma; thus, identifying other modifiable determinants may have far-reaching outcomes. There has been increasing interest in vitamin D status and glaucoma pathogenesis as low vitamin D has been identified by some studies as an independent risk factor for glaucoma. Although the exact mechanism of vitamin D in glaucoma remains uncertain, there is sufficient evidence to continue research in this area. Read More

Br J Ophthalmol 2020 Jun 30. Epub 2020 Jun 30.

Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Shatin, Hong Kong

Aims: To compare the intraocular pressure (IOP) lowering effect and safety profile between pattern scanning laser trabeculoplasty (PSLT) and selective laser trabeculoplasty (SLT) in patients with primary open-angle glaucoma (POAG) or ocular hypertension (OHT) over a 12-month follow-up.

Methods: 132 patients with POAG or OHT were consecutively enrolled and randomised (1:1) to receive PSLT (n=65) or SLT (n=67) in a single centre. IOP was measured before and then on 1 day, 1 week, 1, 3, 6, 9 and 12 months after PSLT/SLT. Read More

Acta Ophthalmol 2020 Jun 29. Epub 2020 Jun 29.

Glaucoma Research Center, Montchoisi Clinic, Swiss Visio, Lausanne, Switzerland.

Purpose: To compare the long-term safety and efficacy of pattern scanning laser trabeculoplasty (PSLT) and selective laser trabeculoplasty (SLT).

Methods: This was a retrospective database analysis (Lausanne Laser Trabeculoplasty Registry) of patients having had laser trabeculoplasty (LT) prior to 2017 with a minimum follow-up of 1 year. Inclusion criteria were age ≥40 years and diagnosis of ocular hypertension (OHT) and open-angle glaucoma (OAG). Read More

Am J Ophthalmol Case Rep 2020 Sep 15;19:100782. Epub 2020 Jun 15.

Department of Frontier Medical Science and Technology for Ophthalmology, Kyoto Prefectural University of 
Medicine, Kyoto, Japan.

Purpose: To report a particular circumstance that led to the abnormal complication of choroidal detachment (CD)-induced secondary angle-closure after trabeculectomy with mitomycin C (MMC).

Observations: An 82-year-old Japanese male patient with underlying chronic obstructive pulmonary disease and suspicion of ocular venous congestion in both eyes whom diagnosed as primary open-angle glaucoma with uncontrolled intraocular pressure (IOP) of his left eye then underwent an uneventful trabeculectomy with MMC. After the surgery, his left eye had high IOP with a shallow anterior chamber (A/C) but the bleb was hyperfiltration. Read More

Acta Clin Croat 2019 Dec;58(4):767-770

Department of Ophthalmology, Sestre milosrdnice University Hospital Centre, Zagreb, Croatia.

The XEN gel stent is one of the available minimally invasive glaucoma surgery devices, a new generation implant, which is designed to reduce intraocular pressure in patients with primary open angle glaucoma if past medical treatments have failed. This report presents a case of subconjunctival fragmentation of the XEN gel stent after a three-month follow-up of successful XEN gel implantation. A 70-year-old male patient was treated for primary open angle glaucoma. Read More

Adv Gerontol 2020 ;33(2):346-351

City Hospital № 2, 5 Uchebniy per., St. Petersburg 194354, Russian Federation.

Around 1,3 billion people live worldwide with visual analyzer disorders such as glaucoma and cataract. These diseases are particularly common among the elderly. From glaucoma every year 10 million people completely lose vision, one of the factors of which is untimely diagnosis. Read More

J Ophthalmol 2020 8;2020:8324319. Epub 2020 Jun 8.

Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago College of Medicine, Chicago, IL, USA.

Background: Primary open-angle glaucoma (POAG) is associated with systemic microvascular dysfunction including hemorrhages and other abnormalities of the nailfold capillary bed. This study aimed to verify the specificity of nailfold capillary hemorrhages and other abnormalities as risk factors for POAG.

Methods: Nailfold video capillaroscopy was performed using a JH-1004 capillaroscope on the fourth and fifth digits of the nondominant hand in control ( = 277), POAG ( = 206), OHT ( = 57), and SG ( = 29) subjects. Read More

J Ophthalmol 2020 9;2020:5742832. Epub 2020 Jun 9.

Eye Center of Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, China.

Purpose: To determine the effectiveness and safety of selective laser trabeculoplasty (SLT) in young patients with primary open-angle glaucoma (POAG) and ocular hypertension (OHT).

Methods: This was a retrospective clinical study. Fifty-six eyes from 56 young (age ≤ 40 y) patients with POAG or OHT treated with SLT were included. Read More

J Curr Glaucoma Pract 2020 Jan-Apr;14(1):16-24

Department of Ophthalmology, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt.

Purpose: To develop a new structural algorithm derived from optical coherence tomography (OCT) retinal nerve fiber layer (RNFL) thickness and asymmetry and validate it as a discriminate among normal, suspect, and early primary open-angle glaucoma (POAG).

Study Design: A case-controlled observational clinical study.

Materials And Methods: In total, 150 subjects (299 eyes) were selected, 61 normal, 46 suspect, and 43 early glaucoma, from Al-Azhar University Hospitals. Read More

J Curr Glaucoma Pract 2020 Jan-Apr;14(1):10-15

Fundación Oftalmológica Nacional, Bogota, Colombia.

Aim: To describe the clinical and epidemiological characteristics of children with pediatric glaucoma (PG) treated in an ophthalmologic national reference center.

Materials And Methods: A retrospective study of patients diagnosed with PG in a national ophthalmologic reference center was made, between 2005 and 2015. Clinical findings, type of treatment, and the follow-up were evaluated. Read More

J Cereb Blood Flow Metab 2020 Jun 24:271678X20935274. Epub 2020 Jun 24.

Department of Radiology, Beijing Tongren Hospital, Capital Medical University, Beijing, China.

Primary open-angle glaucoma (POAG) has been suggested to be a neurodegenerative disease associated with altered cerebral vascular hemodynamics and widespread disruption of neuronal activity within the visual, working memory, attention and executive networks. We hypothesized that disturbed neurovascular coupling in visual and higher order cognitive cortices exists in POAG patients and correlates with glaucoma stage and visual field defects. Through multimodal magnetic resonance imaging, we evaluated the cerebral blood flow (CBF)-functional connectivity strength (FCS) correlations of the whole gray matter and CBF/FCS ratio per voxel for all subjects. Read More

PLoS One 2020 24;15(6):e0232111. Epub 2020 Jun 24.

Department of Pharmacology and Neuroscience and the North Texas Eye Research Institute, University of North Texas Health Science Center at Fort Worth, Fort Worth, TX, United States of America.

Glaucoma is the second leading cause of irreversible blindness worldwide. Primary open angle glaucoma (POAG), the most common form of glaucoma, is often associated with elevation of intraocular pressure (IOP) due to the dysfunction of trabecular meshwork (TM) tissues. Currently, an ex vivo human anterior segment perfusion cultured system is widely used to study the effects of glaucoma factors and disease modifying drugs on physiological parameters like aqueous humor (AH) dynamics and IOP homeostasis. Read More

Am J Ophthalmol 2020 Jun 20. Epub 2020 Jun 20.

Department of Ophthalmology, SeoulNationalUniversityHospital, SeoulNationalUniversityCollege of Medicine, Seoul, Korea. Electronic address:

Purpose: To compare the accuracy for glaucomatous defects and diagnostic power for primary open-angle glaucoma (POAG) between swept-source optical coherence tomography (SS-OCT) and spectral-domain optical coherence tomography (SD-OCT) in myopic eyes.

Design: Prospective, case-control study METHODS: One hundred and fifty (150) myopic POAG eyes and 100 healthy myopic eyes underwent SD-OCT and SS-OCT in random order, on the same day. The locations of glaucomatous defect on SD-OCT thickness and deviation maps and SS-OCT wide-field thickness (thickness surface) and SuperPixel maps were rated, and the maps' accuracies were compared. Read More

Jpn J Ophthalmol 2020 Jul 22;64(4):398-406. Epub 2020 Jun 22.

Santen Inc., Emeryville, CA, USA.

Purpose: Omidenepag isopropyl (OMDI) is the prodrug of omidenepag, a selective, non-prostaglandin, prostanoid EP2 receptor agonist, which has been shown to lower intraocular pressure (IOP) in patients with glaucoma and ocular hypertension (OHT). This study evaluated the efficacy and safety of OMDI ophthalmic solution 0.002% in patients with primary open-angle glaucoma or OHT who were non-/low responders to latanoprost. Read More

Jpn J Ophthalmol 2020 Jul 22;64(4):414-422. Epub 2020 Jun 22.

Department of Ophthalmology E7, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan.

Purpose: To evaluate the relationship between peripapillary tilt and visual field (VF) defects in glaucomatous eyes with axial myopia.

Study Design: Retrospective cross-sectional study.

Patients And Methods: One hundred four eyes of 104 patients with primary open-angle glaucoma (POAG) with myopia were included (52 eyes with high myopia [HM], 26. Read More

J Cataract Refract Surg 2020 Jun 18. Epub 2020 Jun 18.

From Vold Vision (Rather, Vold, McFarland), Fayetteville, Arkansas, and the University of Arkansas for Medical Sciences, College of Medicine (Rather), Little Rock, Arkansas, USA.

Purpose: To provide safety and effectiveness outcomes at 12 months post-surgery for an ab interno transscleral gelatin stent in patients with advanced refractory glaucoma or intolerant of medical therapy.

Setting: Multisubspecialty ophthalmology practice and surgery center.

Design: Retrospective, single arm, cohort study METHODS:: All patients implanted with the gelatin stent either combined with cataract surgery or as a solo procedure between February 2017 and April 2018 and meeting eligibility criteria were included. Read More

J Glaucoma 2020 Jun 19. Epub 2020 Jun 19.

Institute of Ophthalmology and Visual Science, Rutgers New Jersey Medical School, Newark, New Jersey, USA.

Purpose: To provide the first report on argon laser peripheral iridoplasty to restore XEN-45 Gel stent patency after iris occlusion.

Methods: Case description, laser technique, and relevant clinical imaging.

Results: A 53-year-old African American male patient presented with progressive advanced stage primary open angle glaucoma. Read More

J Glaucoma 2020 Jun 19. Epub 2020 Jun 19.

Department of Surgical & Clinical, Diagnostic and Pediatric Sciences, Section of Ophthalmology, University of Pavia - IRCCS Fondazione Policlinico San Matteo, Pavia, Italy.

Purpose: To describe a case of delayed-onset hemorrhagic choroidal detachment (HCD) in a patient affected by primary open-angle glaucoma (POAG) undergone PreserFlo Microshunt® implantation.

Case Report Description: A 76-year-old POAG patient, under treatment with Dabigatran (a novel oral anticoagulant, NOAC), underwent an uncomplicated PreserFlo Microshunt® implantation in the left eye. In the first post-operative day, intraocular pressure (IOP) was 6▒mm Hg, conjunctival bleb was diffuse, anterior chamber (AC) deep, and device correctly positioned. Read More

Int J Ophthalmol 2020 18;13(6):941-945. Epub 2020 Jun 18.

Department of Ophthalmology, Faculty of Medical Sciences, University of Fukui, Fukui 910-1193, Japan.

Aim: To compare surgical outcomes of phacoemulsification combined with glaucoma surgical techniques performed with either Kahook Dual Blade (KDB) or iStent for Japanese patients with either primary open angle glaucoma or exfoliation glaucoma.

Methods: We retrospectively evaluated the surgical outcomes of 129 eyes of 84 Japanese patients with glaucoma who underwent KDB or 44 eyes of 34 patients who underwent phacoemulsification with iStent procedures combined with cataract surgery. The primary outcome was surgical success or failure [with surgical failure being indicated by <20% reduction from preoperative intraocular pressure (IOP) or IOP>18 mm Hg as criterion A; IOP>14 mm Hg as criterion B on two consecutive study visits; or reoperation requirement]. Read More

Mol Vis 2020 5;26:434-444. Epub 2020 Jun 5.

Department of Pharmacology and Neuroscience, North Texas Eye Research Institute, University of North Texas Health Science Center at Fort Worth, TX.

Chronic elevation of intraocular pressure (IOP) is a major risk factor associated with primary open angle glaucoma (POAG), a common form of progressive optic neuropathy that can lead to debilitating loss of vision. Recent studies have identified the role of nitric oxide (NO) in the regulation of IOP, and as a result, several therapeutic ventures are currently targeting enhancement of NO signaling in the eye. Although a low level of NO is important for ocular physiology, excess exogenous NO can be detrimental. Read More

Ophthalmology 2020 Jul;127(7):908-909

J Fr Ophtalmol 2020 Jun 16. Epub 2020 Jun 16.

Ophthalmology Department, Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts, IHU FOReSIGHT, 28, rue de Charenton, 75012 Paris, France; Ophthalmology Department, hôpital Ambroise-Paré, IHU FOReSIGHT, AP-HP, 9, avenue Charles-De-Gaulle, 92100 Boulogne-Billancourt, France; Université de Versailles Saint-Quentin-en-Yvelines, 78000 Versailles, France; Inserm, CNRS, Institut de la Vision, Sorbonne University, 17, rue Moreau, 75012 Paris, France.

Glaucoma is a blinding optic neuropathy, the main risk factor for which is increased intraocular pressure (IOP). The trabecular meshwork, located within the iridocorneal angle, is the main pathway for drainage of aqueous humor (AH) out of the eye, and its dysfunction is responsible for the IOP elevation. The trabecular meshwork is a complex, fenestrated, three-dimensional structure composed of trabecular meshwork cells (TMC) interdigitated into a multilayered organization within the extracellular matrix (ECM). Read More

Stem Cells 2020 Jun 18. Epub 2020 Jun 18.

Department of Ophthalmology and Visual Sciences, University of Nebraska Medical Center, Omaha, Nebraska, USA.

Glaucoma is characterized by a progressive degeneration of retinal ganglion cells (RGCs), leading to irreversible vision loss. Currently, there is no effective treatment for RGC degeneration. We are using a disease in a dish stem cell model to examine the developmental susceptibility of RGCs to glaucomatous degeneration, which may inform on the formulation of therapeutic approaches. Read More

Sci Rep 2020 Jun 17;10(1):9815. Epub 2020 Jun 17.

Department of Ophthalmology and Visual Sciences, McPherson Eye Research Institute, University of Wisconsin-Madison, Madison, WI, United States.

Elevated intraocular pressure (IOP) is a major risk factor for the development and progression of primary open angle glaucoma and is due to trabecular meshwork (TM) damage, which leads to impaired aqueous humor outflow. Here, we explore a novel molecular mechanism involved in glaucomatous TM damage. We investigated the role of an endogenous Toll-like receptor 4 (TLR4) ligand, fibronectin-EDA (FN-EDA), in TGFβ2-induced ocular hypertension in mice. Read More

J Glaucoma 2020 Jun 16. Epub 2020 Jun 16.

Department of Ophthalmology, The University of Tokyo.

Purpose: To investigate the association of Corneal Hysteresis (CH) measured with Ocular Response Analyzer on the progression of glaucoma after trabeculectomy.

Methods: 24 eyes of 19 patients with primary open-angle glaucoma underwent trabeculectomy. A series of Visual fields (Humphery Field Analyzer 24-2 SITA-standard) were measured starting after six months after trabeculectomy (4. Read More

J Glaucoma 2020 Jun 16. Epub 2020 Jun 16.

Department of Ophthalmology, Medical Park Izmir Hospital, Izmir, Turkey.

PRéCIS:: In the adult offspring of glaucoma patients, RNFL and GCC thickness in the especially inferior quadrant were significantly decreased. This finding in the adult offspring of glaucoma patients may be important in evaluating the course of glaucoma disease.

Purpose: The aim of this study is to investigate retinal nerve fiber layer and ganglion cell complex thickness in adult offspring of primer open angle glaucoma patients and to compare the results with individuals without a family history for glaucoma disease. Read More

Clin Ophthalmol 2020 28;14:1483-1494. Epub 2020 May 28.

Department of Ophthalmology, University Hospital Essen, Essen, Germany.

Purpose: Diagnostic 24-hour intraocular pressure curves (IPC) are well established in the management of glaucoma. However, objective criteria for the IPC indication are lacking. The aim of this study was to evaluate the impact of individual patient characteristics and glaucoma-related parameters on therapy decisions after IPC and thus examine their relevance for glaucoma management. Read More

BMC Ophthalmol 2020 Jun 16;20(1):231. Epub 2020 Jun 16.

Department of Ophthalmology 2, Quinze-Vingts National Ophthalmology Hospital, IHU FOReSIGHT, University Paris Descartes, 28 rue de Charenton, 75012, Paris, France.

Background: To compare the efficacy of phacoemulsification (PKE) combined with nonpenetrating deep sclerectomy (NPDS) with mitomycin C (MMC) versus XEN® gel stent with MMC.

Methods: In this nonrandomized, retrospective, comparative, single-center pilot study, 105 consecutive eyes of 75 patients with uncontrolled primary open-angle glaucoma (POAG) and cataract who underwent PKE combined with either XEN implantation (n = 47) or NPDS (n = 58) between May 2013 and November 2018 were included. The primary outcome was complete success at 9 months, which was defined as intraocular pressure (IOP) ≤18, 15 or 12 mmHg without treatment; qualified success was IOP ≤18, 15 or 12 mmHg with antiglaucoma medications. Read More

Curr Eye Res 2020 Jul 7:1-11. Epub 2020 Jul 7.

Department of Ophthalmology, Dicle University Faculty of Medicine , Diyarbakır, Turkey.

Purpose: To determine the diurnal variations in parafoveal and peripapillary vessel density using optical coherence tomography angiography in patients with exfoliative glaucoma, patients with primary open-angle glaucoma and healthy individuals.

Materials And Methods: In this prospective cross-sectional study, 36 exfoliative glaucoma patients, 34 primary open-angle glaucoma patients and 35 healthy individuals were examined. Optical coherence tomography angiography was used for examining the vessel density of peripapillary (radial peripapillary capillary) and parafoveal (superficial layer) regions. Read More

Microorganisms 2020 Jun 13;8(6). Epub 2020 Jun 13.

Department of Internal Medicine, Second Medical Clinic, Ippokration Hospital, Aristotle University of Thessaloniki, 54642 Thessaloniki, Macedonia, Greece.

: Glaucoma is the second most common cause of blindness worldwide affecting almost 70 million individuals. is a widespread pathogen with systematic pathogenicity. This meta-analysis aimed to estimate the contradictory data regarding a potential association between active infection and glaucoma. Read More

Int J Mol Sci 2020 Jun 11;21(11). Epub 2020 Jun 11.

Department of Clinical Chemistry and Biochemistry, Medical University of Lodz, 90-419 Lodz, Poland.

Glaucoma is a heterogenous, chronic, progressive group of eye diseases, which results in irreversible loss of vision. There are several types of glaucoma, whereas the primary open-angle glaucoma (POAG) constitutes the most common type of glaucoma, accounting for three-quarters of all glaucoma cases. The pathological mechanisms leading to POAG pathogenesis are multifactorial and still poorly understood, but it is commonly known that significantly elevated intraocular pressure (IOP) plays a crucial role in POAG pathogenesis. Read More

Ophthalmology 2020 Jun 13. Epub 2020 Jun 13.

Hamilton Glaucoma Center, Shiley Eye Institute and Viterbi Family Department of Ophthalmology, University of California, San Diego, California.

Objective: To evaluate the intraocular pressure (IOP)-lowering efficacy and safety of 10- and 15-μg bimatoprost implant in subjects with open-angle glaucoma (OAG) and ocular hypertension (OHT) after initial and repeated administrations.

Design: Randomized, 20-month, multicenter, subject- and efficacy evaluator-masked, parallel-group, phase 3 clinical study.

Participants: Adults with OAG or OHT in each eye, open iridocorneal angle inferiorly in the study eye by clinical gonioscopy, and study eye baseline IOP (H0; 8 am±1 h) of 22-32 mmHg after washout. Read More

Invest Ophthalmol Vis Sci 2020 Jun;61(6):36

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Purpose: The purpose of this study was to investigate changes in lamina cribrosa (LC) depth after trabeculectomy in myopic eyes using enhanced depth imaging (EDI) spectral-domain optical coherence tomography (SD-OCT).

Methods: Serial horizontal B-scans of the optic nerve head of 41 myopic eyes with primary open-angle glaucoma (POAG) were obtained before and 3 months after trabeculectomy using EDI SD-OCT. LC depth, defined as the distance from the opening plane of Bruch's membrane to the level of the anterior LC surface, was measured before and 3 months after trabeculectomy at 7 locations spaced equidistantly across the vertical optic disc diameter on B-scan images. Read More

Am J Ophthalmol 2020 Jun 10. Epub 2020 Jun 10.

Santen Inc., Emeryville, California; Santen Pharmaceutical Co. Ltd., Osaka, Japan.

Purpose: To evaluate the efficacy and safety of omidenepag isopropyl (OMDI), a selective, non-prostaglandin, prostanoid EP2 receptor agonist, in Japanese patients with primary open-angle glaucoma (POAG) or ocular hypertension (OHT).

Design: Phase 3, randomized, investigator-masked, active-controlled, parallel-group, non-inferiority study (NCT02623738).

Methods: After a washout period of 1-4 weeks, eligible patients were randomized (1:1) to OMDI 0. Read More

Acta Ophthalmol 2020 Jun 13. Epub 2020 Jun 13.

Department of Ophthalmology, Graduate of Medicine and Faculty of Medicine, The University of Tokyo, Tokyo, Japan.

Purpose: To report the occurrence probability of disc haemorrhage (DH) and risk factors for it in otherwise healthy Japanese normal-tension glaucoma (NTG) patients who had lower normal intraocular pressure (IOP) and were followed without treatment for 5 years.

Methods: A prospective observational study. Normal-tension glaucoma (NTG) patients with IOP consistently ≤15 mmHg without treatment were enrolled. Read More

Commun Biol 2020 Jun 11;3(1):301. Epub 2020 Jun 11.

Kaiser Permanente Northern California (KPNC), Division of Research, Oakland, CA, 94612, USA.

Central corneal thickness (CCT) is one of the most heritable human traits, with broad-sense heritability estimates ranging between 0.68 to 0.95. Read More