7,701 results match your criteria Glaucoma Primary Open Angle


Elevated Plasma Levels of Drebrin in Glaucoma Patients With Neurodegeneration.

Front Neurosci 2019 3;13:326. Epub 2019 Apr 3.

State Key Laboratory of Ophthalmology, Optometry and Visual Science, The Eye Hospital of Wenzhou Medical University, Wenzhou, China.

Glaucoma is an optic neuropathy characterized by progressive degeneration of retinal ganglion cells (RGCs). Aberrations in several cytoskeletal proteins, such as tau have been implicated in the pathogenesis of neurodegenerative diseases, could be initiating factors in glaucoma progression and occurring prior to axon degeneration. Developmentally regulated brain protein (Drebrin or DBN1) is an evolutionarily conserved actin-binding protein playing a prominent role in neurons and is implicated in neurodegenerative diseases. Read More

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http://dx.doi.org/10.3389/fnins.2019.00326DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456690PMC

Mutant RAMP2 causes primary open-angle glaucoma via the CRLR-cAMP axis.

Genet Med 2019 Apr 19. Epub 2019 Apr 19.

The Key Laboratory for Human Disease Gene Study of Sichuan Province and Department of Laboratory Medicine, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan, China.

Purpose: Primary open-angle glaucoma (POAG) is the leading cause of irreversible blindness worldwide and mutations in known genes can only explain 5-6% of POAG. This study was conducted to identify novel POAG-causing genes and explore the pathogenesis of this disease.

Methods: Exome sequencing was performed in a Han Chinese cohort comprising 398 sporadic cases with POAG and 2010 controls, followed by replication studies by Sanger sequencing. Read More

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http://www.nature.com/articles/s41436-019-0507-0
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http://dx.doi.org/10.1038/s41436-019-0507-0DOI Listing
April 2019
1 Read

Detection of proteins associated with extracellular matrix regulation in the aqueous humour of patients with primary glaucoma.

Curr Eye Res 2019 Apr 17. Epub 2019 Apr 17.

a R.S. Mehta Jain Department of Biochemistry and Cell Biology , KBIRVO, Vision Research Foundation, Sankara Nethralaya , Chennai , India .

Purpose: The protein composition of aqueous humour (AH) has held significant relevance and remains to be the prime sample in the discovery of biomarkers in glaucoma. The purpose of this study is to analyze the aqueous humour protein concentrations in primary open angle glaucoma (POAG) and primary angle closure glaucoma (PACG) and further examine the proteome changes compared to cataract control.

Methods: Aqueous humour was collected from 90 POAG, 72 PACG, 78 cataract (control) in this study. Read More

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http://dx.doi.org/10.1080/02713683.2019.1608261DOI Listing
April 2019
1.663 Impact Factor

Bilateral angle closure glaucoma in a teenage girl - A rare presentation in Arab population - A case report.

Authors:
Sultan Alzuhairy

Int J Health Sci (Qassim) 2019 Mar-Apr;13(2):56-58

Department of Ophthalmology, College of Medicine, Qassim University, Qassim, Saudi Arabia.

Primary angle closure glaucoma (PACG) usually presents as unilateral and has acute onset. In Arab population, the proportion of open- and closed-angle glaucoma is similar. To the best of our knowledge, chronic PACG in very young age is rare. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6436444PMC

Mapping mRNA expression of glaucoma genes in the healthy mouse eye.

Curr Eye Res 2019 Apr 12. Epub 2019 Apr 12.

a University Eye Clinic Maastricht, Maastricht University Medical Center , Maastricht , the Netherlands.

Purpose/Aim: Many genes have been associated with primary open-angle glaucoma (POAG). Knowing exactly where they are expressed in the eye helps to unravel POAG pathology and to select optimal targets for intervention. We investigated whether RNA in-situ hybridization (RNA-ISH) is a convenient technique to obtain detailed pan-ocular expression data of these genes. Read More

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http://dx.doi.org/10.1080/02713683.2019.1607392DOI Listing

Clinical application of NGS-based SNP haplotyping for the preimplantation genetic diagnosis of primary open angle glaucoma.

Syst Biol Reprod Med 2019 Apr 12:1-6. Epub 2019 Apr 12.

b Prenatal Diagnosis Centre , Northwest Women's and Children's Hospital , Xi'an , China.

The current study describes a successful case of preimplantation genetic diagnosis (PGD) of primary open angle glaucoma (POAG) and verifies the efficiency of next-generation sequencing (NGS)-based haplotyping for PGD of POAG. In this study, we applied NGS as part of PGD to effectively detect POAG prior to embryo implantation and avoid the prospect of pregnancy termination in event of vertical inheritance of POAG. We used the technique of multiple annealing and looping based amplification cycles (MALBAC) to conduct whole genome amplification (WGA) and to reduce the allele dropout (ADO). Read More

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https://www.tandfonline.com/doi/full/10.1080/19396368.2019.1
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http://dx.doi.org/10.1080/19396368.2019.1590479DOI Listing
April 2019
2 Reads

Randomized crossover trial comparing effectiveness and tolerability of generic and brand-name travoprost.

Can J Ophthalmol 2019 Apr 22;54(2):223-228. Epub 2018 Jun 22.

Department of Ophthalmology, Centre Hospitalier Universitaire de Sherbrooke - Hôtel-Dieu, University of Sherbrooke, Sherbrooke, Quebec.

Objective: The primary goal is to determine if the intraocular pressure reducing effect of generic Sandoz travoprost is equivalent to that of brand-name Travatan Z. The secondary goal is to determine if generic Sandoz travoprost is as well tolerated as Travatan Z.

Methods: This prospective randomized crossover trial allocated 76 patients with primary open-angle glaucoma, normotensive glaucoma, or ocular hypertension in a 1:1 ratio to start with either generic Sandoz travoprost or Travatan Z. Read More

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http://dx.doi.org/10.1016/j.jcjo.2018.04.017DOI Listing

Evaluation of dynamic thiol-disulfide homeostasis in glaucoma patients and the correlation with retinal nerve fiber layer analysis.

Eur J Ophthalmol 2019 Apr 12:1120672119839582. Epub 2019 Apr 12.

3 Biochemistry Department, Ankara Atatürk Education and Research Hospital, Ankara, Turkey.

Purpose: The aim of this study was to evaluate thiol/disulfide homeostasis and ischemia-modified albumin levels with primary open-angle glaucoma, ocular hypertension, and control group; also to interpret the correlation between these biochemical parameters and retinal nerve fiber layer analysis.

Material And Methods: In a prospective cross-sectional study, 30 primary open-angle glaucoma cases, 30 ocular hypertension cases, and 30 control subjects were included in the study. Native thiol, total thiol, and disulfide measurements and disulfide/native thiol, disulfide/total thiol, and native thiol/total thiol ratios were evaluated as thiol-disulfide homeostasis. Read More

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http://dx.doi.org/10.1177/1120672119839582DOI Listing
April 2019
1 Read

Nailfold Capillaroscopy of Resting Peripheral Blood Flow in Exfoliation Glaucoma and Primary Open-Angle Glaucoma.

JAMA Ophthalmol 2019 Apr 11. Epub 2019 Apr 11.

Einhorn Clinical Research Center, Department of Ophthalmology, New York Eye and Ear Infirmary of Mount Sinai, New York.

Importance: Systemic blood flow alterations have been described using video nailfold capillaroscopy (NFC) in high-tension glaucoma (HTG) and normal-tension glaucoma (NTG) variants of primary open-angle glaucoma (POAG). To date, no previous studies have explored alterations in nailfold capillary blood flow in exfoliation glaucoma (XFG).

Objective: To investigate the measure of peripheral blood flow as a surrogate marker of systemic vascular involvement in patients with XFG, HTG, and NTG, as well as in individuals serving as controls, using NFC. Read More

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http://dx.doi.org/10.1001/jamaophthalmol.2019.0434DOI Listing
April 2019
1 Read

Polygenic Risk Score Is Associated With Intraocular Pressure and Improves Glaucoma Prediction in the UK Biobank Cohort.

Transl Vis Sci Technol 2019 Apr 4;8(2):10. Epub 2019 Apr 4.

Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, IL, USA.

Purpose: Elevated intraocular pressure (IOP) is an important risk factor for glaucoma. We constructed polygenic risk scores (PRSs) for IOP using the UK Biobank (UKB) data set to test whether the PRSs are associated with IOP and whether using them improves glaucoma prediction.

Methods: We conducted this study using 435,678 European participants from the UKB. Read More

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http://dx.doi.org/10.1167/tvst.8.2.10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6450641PMC

Correlation between structural progression in glaucoma and obstructive sleep apnea.

Eye (Lond) 2019 Apr 10. Epub 2019 Apr 10.

Department of Ophthalmology, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taoyuan, Taiwan.

Background/objectives: To investigate the correlation between obstructive sleep apnea (OSA) severity and the structural and functional progression in patients with glaucoma.

Subjects/methods: This retrospective comparative cohort study included subjects from the polysomnography database in Chang Gung Memorial Hospital between June 1, 2009, and June 1, 2017, by identifying patients who had received diagnoses of primary open-angle glaucoma (POAG), normal-tension glaucoma (NTG), or glaucoma suspect. Patients with follow-up time of <3 years and/or <3 consecutive reliable optical coherence tomography (OCT) or visual field (VF) tests were excluded. Read More

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http://dx.doi.org/10.1038/s41433-019-0430-2DOI Listing
April 2019
3 Reads

Interaction between XRCC 1 gene polymorphisms and diabetes on susceptibility to primary open-angle glaucoma.

Exp Biol Med (Maywood) 2019 Apr 11:1535370219842791. Epub 2019 Apr 11.

Department of Ophthalmology, Second Hospital of Jilin University, Jilin University, Changchun 130041, China.

Impact Statement: Some studies have suggested that diabetes and XRCC gene may be risk factors for glaucoma; however, no studies have focused on the interaction between the XRCC gene and T2DM with respect to POAG risk. Therefore, the present study evaluated the initiative gene-environment interactions in POAG. Read More

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http://dx.doi.org/10.1177/1535370219842791DOI Listing

Comparison of cytokine/chemokine levels in aqueous humor of primary open-angle glaucoma patients with positive or negative outcome following trabeculectomy.

Biosci Rep 2019 Apr 9. Epub 2019 Apr 9.

Rostock University Medical Center, Rostock, Germany.

We aimed to identify differences in cytokine/chemokine levels in the aqueous humor (AH) of primary open-angle glaucoma (POAG) patients who suffered from scarring, compared to POAG patients with no scarring after trabeculectomy surgery. Identification of differently expressed cytokines and chemokines may help to understand scarring and fibrotic processes following trabeculectomy, and to make predictions for the outcome of fistulating surgery in the future. Furthermore, the identification of cell signaling pathways involved in fibrosis offers the opportunity for a more specific antifibrotic therapy with reduced side effects, and an improvement in long-term surgical outcome. Read More

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http://dx.doi.org/10.1042/BSR20181894DOI Listing

Possible Role of Differentially Expressing Novel Protein Markers (Ligatin and Fibulin-7) in Human Aqueous Humor and Trabecular Meshwork Tissue in Glaucoma Progression.

Cell Biol Int 2019 Apr 8. Epub 2019 Apr 8.

Biochemistry and Environmental Toxicology, Laboratory # 103, School of Environmental Sciences, Jawaharlal Nehru University, New Delhi, India.

The pathological mechanism underlying glaucoma has always been a complex aspect of this permanently blinding disease but proteomic studies have been helpful in elucidating it to a great extent in several studies. This study was designed to evaluate the expression and to get an idea about the function of two novel markers (Ligatin and Fibulin-7) identified in human aqueous humor (hAH) in relation to glaucomatous progression. A significant increase in the protein content of glaucomatous hAH compared to that of non-glaucomatous controls (NG-Ctrls) was observed. Read More

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http://dx.doi.org/10.1002/cbin.11138DOI Listing
April 2019
1 Read
1.933 Impact Factor

Prevalence and Clinical Characteristics of Childhood Glaucoma at A Tertiary Care Children's Hospital.

J Glaucoma 2019 Apr 3. Epub 2019 Apr 3.

Akron Children's Hospital, Akron OH.

Precis: Glaucoma suspect was the most prevalent category in this study followed by glaucoma associated with acquired ocular anomaly and juvenile open-angle glaucoma. Primary congenital glaucoma was diagnosed in only 3% of the population studied.

Purpose: To describe the prevalence and clinical characteristics of childhood glaucoma diagnosed over a 10-year period among patients ≤18 years of age who were seen at a tertiary care children's hospital using the new Childhood Glaucoma Research Network (CGRN) classification system. Read More

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http://dx.doi.org/10.1097/IJG.0000000000001259DOI Listing

Endothelin-1 Concentration in Aqueous Humor Predicts Postoperative Late Low Intraocular Pressure in Primary Open Angle Glaucoma After Trabeculectomy.

J Glaucoma 2019 Apr 3. Epub 2019 Apr 3.

Department of Ophthalmology, XiangYang NO.1 People's Hospital, Affiliated Hospital of Hubei University of Medicine.

Background: This study aimed to evaluate potential risk factors for postoperative late low intraocular pressure (IOP) in patients with primary open angle glaucoma (POAG) after trabeculectomy.

Methods: Adult patients who were diagnosed with POAG and scheduled to perform primary unilateral trabeculectomy in our hospital were consecutively included. Blood samples prior to the surgery and aqueous humor samples during the surgery of each participant were collected. Read More

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http://dx.doi.org/10.1097/IJG.0000000000001254DOI Listing

Clinicopathologic Examination of Translucent Refractile Intraluminal Tissue Coagulum From the Proximal Tube of a Baerveldt Glaucoma Drainage Device.

J Glaucoma 2019 Apr;28(4):e64-e65

Birmingham Institute for Glaucoma Research, Institute of Translational Medicine, University Hospitals Birmingham NHS Foundation Trust, Birmingham.

Purpose: To describe an unusual case of glaucoma drainage tube blockage.

Patients: A 76-year-old woman presented with left endothelial graft failure. Her previous ocular history included primary open-angle glaucoma diagnosed for 15 years and Fuch's endothelial dystrophy. Read More

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http://dx.doi.org/10.1097/IJG.0000000000001148DOI Listing
April 2019
2 Reads

Macular ganglion cell-inner plexiform vs retinal nerve fiber layer measurement to detect early glaucoma with superior or inferior hemifield defects.

J Chin Med Assoc 2019 Apr;82(4):335-339

Department of Ophthalmology, Taipei Veterans General Hospital, Taipei, Taiwan, ROC.

Background: To compare the diagnostic ability of Cirrus high-definition spectral-domain optical coherence tomography measurements of the macular ganglion cell-inner plexiform layer (GCIPL) vs the circumferential retinal nerve fiber layer (cpRNFL) to detect early glaucoma with hemifield visual field (VF) defects.

Methods: This prospective study included 96 patients with primary open-angle glaucoma (48 with superior hemifield defects and 48 with inferior hemifield defects) and 48 normal control subjects. All glaucomatous eyes had a mean deviation of the VF defect ≥-6. Read More

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http://dx.doi.org/10.1097/JCMA.0000000000000037DOI Listing
April 2019
1 Read

Changes in ocular signs and symptoms in patients switching from bimatoprost-timolol to tafluprost-timolol eye drops: an open-label phase IV study.

BMJ Open 2019 Apr 2;9(4):e024129. Epub 2019 Apr 2.

Global Medical Affairs, Santen Oy, Helsinki, Finland.

Objectives: Bimatoprost-timolol (bimatoprost 0.03%-timolol 0.5% fixed-dose combination [FDC]) and tafluprost-timolol (tafluprost 0. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-024129DOI Listing

Early results of micropulse transscleral cyclophotocoagulation for the treatment of glaucoma.

Eur J Ophthalmol 2019 Apr 2:1120672119839303. Epub 2019 Apr 2.

1 Department of Ophthalmology and Visual Science, Yale School of Medicine, New Haven, CT, USA.

Purpose:: To describe our clinical experience with the efficacy and safety of micropulse transscleral cyclophotocoagulation as a treatment for glaucoma.

Methods:: In this retrospective case series, we reviewed the charts of 95 consecutive patients with various glaucoma subtypes who underwent micropulse transscleral cyclophotocoagulation. Patients were offered micropulse transscleral cyclophotocoagulation if they had perimetric glaucoma refractory to intraocular pressure-lowering topical medications and who were poor candidates for traditional filtering surgery. Read More

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http://dx.doi.org/10.1177/1120672119839303DOI Listing
April 2019
11 Reads

One-year outcomes following implantation of second-generation trabecular micro-bypass stents in conjunction with cataract surgery for various types of glaucoma or ocular hypertension: multicenter, multi-surgeon study.

Clin Ophthalmol 2019 13;13:491-499. Epub 2019 Mar 13.

Hunter Cataract & Eye Centre, Sydney, NSW, Australia.

Purpose: To assess the utility and safety of implanting two second-generation trabecular micro-bypass stents following cataract surgery in eyes with mild to advanced glaucoma or ocular hypertension (OHT).

Patients And Methods: Retrospective study of iStentinject trabecular micro-bypass implantation with cataract surgery by five surgeons at five sites in Australia. Eyes had mild to advanced glaucoma (predominantly primary open-angle, appositional angle-closure, or pseudoexfoliative glaucoma) or OHT and cataract requiring surgery. Read More

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http://dx.doi.org/10.2147/OPTH.S187272DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6420788PMC

Correlation of the Retinal Parapapillary Perfusion and the Retinal Vessel Oxygen Saturation in Glaucoma Patients.

Invest Ophthalmol Vis Sci 2019 Apr;60(5):1309-1315

Department of Ophthalmology, Jena University Hospital, Jena, Germany.

Purpose: Reduced perfusion of the retinal parapapillary tissue is well documented in glaucoma patients. Whether or not this is a cause or result of the disease is however unknown. Studying the correlation of this perfusion and the retinal vascular oxygen saturation (O2S) could give clues to the retinal O2 consumption/demand and provide an answer to this question. Read More

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http://dx.doi.org/10.1167/iovs.18-26099DOI Listing

[Impact of glaucoma medications and ocular surface disease on the quality of life of glaucoma patients in the district of Sousse (Tunisia)].

J Fr Ophtalmol 2019 Mar 27. Epub 2019 Mar 27.

Service d'ophtalmologie, CHU Farhat Hached, Sousse Tunisie.

Purpose: To assess the impact of glaucoma treatment and ocular surface disease (OSD) on the vision-specific quality-of-life (VS-QoL) of glaucoma patients attending Farhat Hached university hospital Sousse-Tunisia.

Methods: This was a cross-sectional study enrolling one-hundred-twenty patients followed for primary open angle glaucoma. All patients successfully responded to the Arabic version of the National Eye Institute Visual Function Questionnaire 25 (NEI-VFQ 25). Read More

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http://dx.doi.org/10.1016/j.jfo.2018.06.007DOI Listing

Macula Vessel Density and Foveal Avascular Zone Parameters in Exfoliation Glaucoma Compared to Primary Open-Angle Glaucoma.

Invest Ophthalmol Vis Sci 2019 Mar;60(4):1244-1253

Einhorn Clinical Research Center, Department of Ophthalmology, New York Eye and Ear Infirmary of Mount Sinai, New York, New York, United States.

Purpose: The purpose of this study was to explore macula vessel density and foveal avascular zone (FAZ) parameters in exfoliation glaucoma (XFG) compared to primary open-angle glaucoma (POAG) using optical coherence tomography angiography (OCTA).

Methods: This was a cross-sectional observational study. Twenty-six XFG and 28 POAG patients with comparable visual field defects on Humphrey 24-2 and 10-2 perimetries were recruited. Read More

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http://dx.doi.org/10.1167/iovs.18-25986DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440528PMC

Ocular Surface Evaluation After the Substitution of Benzalkonium Chloride Preserved Prostaglandin Eye Drops by a Preservative-free Prostaglandin Analogue.

Med Hypothesis Discov Innov Ophthalmol 2019 ;8(1):52-56

Department of Ophthalmology, Federal University of Brasilia, Brasilia, Brazil.

To evaluate ocular surface changes after withdrawal of Benzalkonium chloride (BAK) in patients with glaucoma in monotherapy with BAK-preserved prostaglandin. This was a prospective observational study. All patients underwent complete ophthalmologic examination and evaluation of ocular surface. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6433198PMC
January 2019

The Effect of Glaucoma Medication on Choroidal Thickness Measured with Enhanced Depth-Imaging Optical Coherence Tomography.

Med Hypothesis Discov Innov Ophthalmol 2019 ;8(1):44-51

Department of Bioistatistics, Ataturk University, Erzurum, Turkey.

The aim of this study was to examine the effect of the glaucoma medication on Choroidal Thickness (CT) in those with Primary Open-Angle Glaucoma (POAG) and normal cases. This prospective study included 27 patients with newly diagnosed POAG (group 1; 49 eyes), undergoing glaucoma treatment, and 30 patients, whose treatment was terminated due to misdiagnosis (group 2; 57 eyes). Choroidal thickness was measured using Enhanced Depth Imaging (EDI) with Spectral Domain Optical Coherence Tomography (SD-OCT) at the first visit and almost one month later. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6433202PMC
January 2019
1 Read

Association of the Myocilin Gene Polymorphism With Primary Open Angle Glaucoma.

Med Hypothesis Discov Innov Ophthalmol 2019 ;8(1):28-33

Eye Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

Glaucoma is the second cause of irreversible blindness, and the Primary Open Angle Glaucoma (POAG) subtype is the most common type of glaucoma. It has been shown that genetic mutations increase the risk of POAG used for early detection. The aim of the current study was to determine the association between genetic variations of Myocilin (MYOC) gene and susceptibility to POAG in the Iranian population. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6433201PMC
January 2019

Corneal biomechanics and biomechanically corrected intraocular pressure in primary open-angle glaucoma, ocular hypertension and controls.

Br J Ophthalmol 2019 Mar 28. Epub 2019 Mar 28.

Biomedical Sciences Research Institute, University of Ulster, Coleraine, UK.

Aims: To compare the biomechanically corrected intraocular pressure (IOP) estimate (bIOP) provided by the Corvis-ST with Goldmann applanation tonometry (GAT-IOP) in patients with high-tension and normal-tension primary open-angle glaucoma (POAG; HTG and NTG), ocular hypertension (OHT) and controls. Moreover, we compared dynamic corneal response parameters (DCRs) of the Corvis-ST in POAG, OHT and controls, evaluated the correlation between global visual field parameters mean deviation and pattern SD (MD and PSD) and DCRs in the POAG group.

Methods: 156 eyes of 156 patients were included in this prospective, single-centre, observational study, namely 41 HTG and 33 NTG, 45 OHT cases and 37 controls. Read More

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http://dx.doi.org/10.1136/bjophthalmol-2018-313493DOI Listing
March 2019
3 Reads

West Indies Glaucoma Laser Study (WIGLS) 3. Anterior Chamber Inflammation Following Selective Laser Trabeculoplasty in Afro-Caribbeans with Open-Angle Glaucoma.

J Glaucoma 2019 Mar 26. Epub 2019 Mar 26.

Department of Epidemiology, Epidemiology Data Center, Graduate School of Public Health, University of Pittsburgh, PA.

Precis: In the absence of prophylactic anti-inflammatory therapy, anterior chamber inflammation (characterized by cells and less commonly flare) is minimal and transient after selective laser trabeculoplasty in Afro-Caribbean glaucoma patients.

Purpose: To characterize the prevalence, severity, and duration of anterior chamber inflammation (cells and flare) following selective laser trabeculoplasty (SLT) in Afro-Caribbean eyes with primary open-angle glaucoma (POAG).

Methods: 144 eyes of 72 POAG patients underwent first-time 360-degree SLT treatment following washout of all topical medications in the prospective West Indies Glaucoma Laser Study. Read More

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http://dx.doi.org/10.1097/IJG.0000000000001250DOI Listing

Influence of Anterior Biometry on Corneal Biomechanical Stiffness of Glaucomatous eyes Treated with Chronic Medication or Filtration Surgery.

J Glaucoma 2019 Mar 26. Epub 2019 Mar 26.

Imaging, Biomechanics, and Mathematical Modeling Solutions Lab, Narayana Nethralaya Foundation, Bangalore, India.

PRéCIS: Anterior chamber depth, IOP and thickness, confounded assessment of corneal biomechanical properties with non-contact applanation in glaucoma eyes. Compared to normal eyes, glaucoma eyes, which underwent long term treatment or filtration surgery, had similar properties.

Purpose: To evaluate corneal stiffness in primary angle closure (PACG) and primary open angle (POAG) glaucoma eyes sub-grouped based on type of topical medication and filtration surgery using non-contact applanation METHODS:: All eyes were retrospectively reviewed for intraocular pressure (IOP) with Corvis-ST (OCULUS Optikgerate Gmbh, Germany). Read More

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http://dx.doi.org/10.1097/IJG.0000000000001247DOI Listing

Short-Term Safety Evaluation of a Multi-Pressure Dial: A Prospective, Open-label, Non-randomized Study.

Ophthalmol Ther 2019 Mar 27. Epub 2019 Mar 27.

Vance Thompson Vision, Sioux Falls, SD, USA.

Introduction: Prospective, open-label, non-randomized, single site study to assess the safety and tolerability of a multi-pressure dial.

Methods: 30 healthy subjects received application of negative pressure (-15 mmHg) in one eye for 30 minutes and ambient atmospheric pressure in the contralateral eye. To evaluate safety, the primary outcome measures included best corrected visual acuity (BCVA), intraocular pressure (IOP) changes from baseline, slit-lamp and dilated fundus examination findings, and rate of adverse events. Read More

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http://dx.doi.org/10.1007/s40123-019-0181-yDOI Listing

Management of the open angle glaucoma in patients with central/hemicentral retinal vein occlusions.

Int J Ophthalmol 2019 18;12(3):436-441. Epub 2019 Mar 18.

Department of Ophthalmology, University of Medicine, Cluj-Napoca 400014, Romania.

Aim: To prospectively assess the cumulative prevalence and management of open angle glaucoma (OAG), including primary open angle glaucoma (POAG) with high and normal-pressure, as well as pseudoexfoliative glaucoma (PEXG), in patients with central/hemicentral retinal vein occlusions (RVOs) over a 3-year follow-up period.

Methods: The study encompassed 57 patients with unilateral acute central/hemicentral RVOs. A complete ophthalmic examination of both eyes was undertaken for all patients. Read More

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http://dx.doi.org/10.18240/ijo.2019.03.14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6423395PMC

Caveolin-1 regulates human trabecular meshwork cell adhesion, endocytosis, and autophagy.

J Cell Biochem 2019 Mar 27. Epub 2019 Mar 27.

Joint Shantou International Eye Center of Shantou University and the Chinese University of Hong Kong, Shantou, Guangdong, China.

Impaired trabecular meshwork (TM) outflow is implicated in the pathogenesis of primary open-angle glaucoma (POAG). We previously identified the association of a caveolin-1 (CAV1) variant with POAG by genome-wide association study. Here we report a study of CAV1 knockout (KO) effect on human TM cell properties. Read More

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http://dx.doi.org/10.1002/jcb.28613DOI Listing
March 2019
1 Read

Ab externo canaloplasty results and efficacy: a retrospective cohort study with a 12-month follow-up.

Eye Vis (Lond) 2019 12;6. Epub 2019 Mar 12.

1St. Johannes Hospital, Eye clinic, Dortmund, Germany.

Background: The aim of this study is to review the outcomes of canaloplasty versus canaloplasty combined with phacoemulsification in a retrospective cohort study and to evaluate the efficacy of these methods in terms of intraocular pressure (IOP) lowering effect, postoperative complications and additional glaucoma surgery or reintroduction of medical therapy over a 12-month follow-up.

Methods: In a retrospective cohort study, 602 eyes with primary open angle glaucoma (POAG) were treated with canaloplasty or canaloplasty combined with phacoemulsification. The results were evaluated separately in two main groups; group A canaloplasty (262 eyes) and group B canaloplasty combined with phaco (322 eyes). Read More

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http://dx.doi.org/10.1186/s40662-019-0134-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417166PMC

Levels of serum trace elements in patients with primary open-angle glaucoma.

J Trace Elem Med Biol 2019 May 15;53:129-134. Epub 2019 Feb 15.

Department of Ophthalmology, University of Erlangen, Schwabachanlage 6, 91054 Erlangen, Germany. Electronic address:

Purpose: Glaucoma disease is known as multifactorial. Trace elements seemed to be linked via oxidative stress mediated changes to the complex glaucoma pathophysiology. Thus, it was the aim of this study to investigate serum levels of trace elements in primary open-angle glaucoma patients (POAG). Read More

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http://dx.doi.org/10.1016/j.jtemb.2019.02.006DOI Listing

Primary Open-angle Glaucoma With Initial Visual Field Damage in the Superior and Inferior Hemifields: Comparison in a Population-based Setting.

J Glaucoma 2019 Mar 22. Epub 2019 Mar 22.

Kanto Central Hospital of the Mutual Aid Association of Public School Teachers.

Purpose: To study differences in systemic and ocular factors between eyes with primary open-angle glaucoma (POAG) with an initial visual field defect (VFD) starting in the superior hemifield and those starting in the inferior hemifield in a population-based setting.

Methods: The data were analyzed from eyes with definitive category-1 POAG based on the International Society of Geographic and Epidemiological Ophthalmology criteria with VFD constriction in the superior or inferior hemifield (superior and inferior VFD groups, respectively) found in two Japanese population-based glaucoma surveys. The VFs were tested using the Humphrey Field Analyzer Central 30-2 or 24-2 Swedish Interactive Thresholding Algorithm Standard program. Read More

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http://dx.doi.org/10.1097/IJG.0000000000001241DOI Listing

Histochemical Analysis of Glaucoma Caused by a Myocilin Mutation in a Human Donor Eye.

Ophthalmol Glaucoma 2018 Sep-Oct;1(2):132-138. Epub 2018 Aug 17.

institute for Vision Research, University of Iowa, Iowa City, IA, USA.

Objective: Mutations in myocilin ( may cause either juvenile open angle glaucoma (JOAG) or adult-onset primary open angle glaucoma (POAG). encodes a glycoprotein that is normally secreted from trabecular meshwork cells that regulate intraocular pressure. Prior transgenic rodent, and organ culture experiments have suggested that abnormal accumulation of MYOC protein within trabecular meshwork cells is a key step in glaucoma pathophysiology. Read More

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http://dx.doi.org/10.1016/j.ogla.2018.08.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425711PMC
August 2018
2 Reads

Comparison of medical comorbidity between patients with primary angle-closure glaucoma and a control cohort: a population-based study from Taiwan.

BMJ Open 2019 Mar 23;9(3):e024209. Epub 2019 Mar 23.

Management Office for Health Data, China Medical University, Taichung, Taiwan.

Objective: To determine the prevalence and risk of systemic comorbidities in primary angle-closure glaucoma in Taiwan population.

Methods: We included 3322 primary angle-closure glaucoma (PACG) subjects and randomly selected patients without PACG from the Taiwan National Health Insurance Research Database and frequency matched four of them (n=13 288) to each PACG patient, based on age and sex. The univariable and multivariable unconditional logistic regression models were used to estimate the effect of comorbidities on the risk of PACG as indicated by the OR with 95% CI. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-024209DOI Listing

Rapamycin Removes Damaged Mitochondria and Protects Human Trabecular Meshwork (TM-1) Cells from Chronic Oxidative Stress.

Mol Neurobiol 2019 Mar 22. Epub 2019 Mar 22.

Department of Ophthalmology and Visual Sciences, Hong Kong Eye Hospital, The Chinese University of Hong Kong, 147K Argyle Street, Kowloon, Hong Kong.

Glaucoma is a chronic optic neuropathy that could lead to permanent vision loss. Primary open-angle glaucoma (POAG) is the most common type of glaucoma, with elevated intraocular pressure (IOP) as a major risk factor. IOP is mainly regulated by trabecular meshwork (TM), an important component of the conventional aqueous humor (AH) outflow pathway. Read More

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http://dx.doi.org/10.1007/s12035-019-1559-5DOI Listing

Effect of Topical Hypotensive Medications for Preventing Intraocular Pressure Increase after Cataract Surgery in Eyes with Glaucoma.

Am J Ophthalmol 2019 Mar 19. Epub 2019 Mar 19.

Hayashi Eye Hospital, Fukuoka, Japan.

Purpose: To compare the effects of a topical intraocular pressure (IOP)-lowering medication for preventing an IOP increase after cataract surgery in eyes with glaucoma.

Design: Randomized clinical study.

Methods: One hundred sixty-five eyes of 165 patients with primary open-angle glaucoma or pseudoexfoliation glaucoma scheduled for phacoemulsification were randomly assigned to one of three groups to receive each medication immediately postoperatively: 1) prostaglandin F2α analogue (travoprost), 2) β-blocker (timolol maleate), or 3) carbonic anhydrase inhibitor (brinzolamide). Read More

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http://dx.doi.org/10.1016/j.ajo.2019.03.012DOI Listing

Association of Gene Polymorphisms With Primary Open Angle Glaucoma: A Systematic Review and Meta-Analysis.

Invest Ophthalmol Vis Sci 2019 Mar;60(4):1105-1121

Eye Center, the 2nd Affiliated Hospital, Medical College of Zhejiang University, Hangzhou, China.

Purpose: To confirm the association of all reported common polymorphisms with POAG.

Methods: We searched in PubMed and Web of Science (up to January 10, 2018) for genetic studies of POAG. All case control studies investigating the association between single-nucleotide polymorphisms (SNPs) and POAG risk were included. Read More

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http://iovs.arvojournals.org/article.aspx?doi=10.1167/iovs.1
Publisher Site
http://dx.doi.org/10.1167/iovs.18-25922DOI Listing
March 2019
3 Reads

Diurnal variations in flow density measured using optical coherence tomography angiography and the impact of heart rate, mean arterial pressure and intraocular pressure on flow density in primary open-angle glaucoma patients.

Acta Ophthalmol 2019 Mar 22. Epub 2019 Mar 22.

Department of Ophthalmology, University of Muenster Medical Centre, Muenster, Germany.

Purpose: To determine the diurnal variations in peripapillary and macular flow density (FD), as measured using optical coherence tomography angiography (OCTA) and to elaborate on the relationship between diurnal FD, circulatory parameters and intraocular pressure (IOP) variations in primary open-angle glaucoma (POAG).

Methods: Forty eyes of 40 POAG patients were drawn into this cross-sectional study. The retinal microvasculature of the macula (superficial and deep layers) and optic nerve [radial peripapillary capillary (RPC)] was examined by OCTA (AngioVue , Optovue). Read More

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http://dx.doi.org/10.1111/aos.14089DOI Listing

Surgical outcomes of combined gonioscopy-assisted transluminal trabeculotomy and cataract surgery.

Indian J Ophthalmol 2019 Apr;67(4):505-508

Kaçkar State Hospital, Department of Ophthalmology, Rize, Turkey.

Purpose: To evaluate the success, safety, and complication rates of gonioscopy-assisted transluminal trabeculotomy (GATT) combined with cataract surgery.

Methods: A retrospective study was conducted for 32 patients who underwent GATT combined with phacoemulsification and intraocular lens implantation. Patients with primary open-angle glaucoma were enrolled. Read More

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http://dx.doi.org/10.4103/ijo.IJO_1007_18DOI Listing

Autoantibody Biomarker Discovery in Primary Open Angle Glaucoma Using Serological Proteome Analysis (SERPA).

Front Immunol 2019 7;10:381. Epub 2019 Mar 7.

Experimental and Translational Ophthalmology, Department of Ophthalmology, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany.

Glaucoma is an optic neurological disorder and the leading cause of irreversible blindness worldwide, with primary open angle glaucoma (POAG) as its most prevalent form. An early diagnosis of the disease is crucial to prevent loss of vision. Mechanisms behind glaucoma pathogenesis are not completely understood, but disease related alterations in the serological autoantibody profile indicate an immunologic component. Read More

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http://dx.doi.org/10.3389/fimmu.2019.00381DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417464PMC

Association between Primary Open-Angle Glaucoma and Cognitive Impairment as Measured by the Montreal Cognitive Assessment.

Neurodegener Dis 2018 20;18(5-6):315-322. Epub 2019 Mar 20.

Scheie Eye Institute, University of Pennsylvania, Philadelphia, Pennsylvania, USA,

Background: It is currently unclear whether primary open-angle glaucoma (POAG) affects neurological functions outside of vision, such as cognition.

Objective: This study examined the association between POAG and cognitive impairment in African Americans.

Methods: Masked interviewers administered the Montreal Cognitive Assessment (MoCA) to patients enrolled in the Primary Open-Angle African American Glaucoma Genetics (POAAGG) study at the Scheie Eye Institute. Read More

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http://dx.doi.org/10.1159/000496233DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6459693PMC
March 2019
9 Reads

The ganglion cell complex as an useful tool in glaucoma assessment.

Rom J Ophthalmol 2018 Oct-Dec;62(4):300-303

Clinical Hospital of Ophthalmologic Emergencies, Bucharest, Romania.

Glaucoma is known as an optic neuropathy prone to progression that determines characteristic not only structural (loss of the ganglion cells as well as their axons) but also functional defects (visual field loss). To evaluate the possibility of applying ganglion cell complex analysis (GCC) in patients who associate ocular hypertension with tilted disc and marked peripapillary atrophy. In order to evaluate its components, GCC can be investigated using the Optical Coherence Tomography (OCT) revealing: ganglion cell layer (cells bodies), inner plexiform layer (dendrites and synapses), and nerve fiber layer (axons). Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421490PMC
April 2019
4 Reads

Subcyclo laser procedure results in patients with glaucoma.

Rom J Ophthalmol 2018 Oct-Dec;62(4):296-299

AMA Optimex Clinic, Bucharest, Romania.

To analyse the results of subCyclo (subliminal transscleral cyclophotocoagulation) laser procedure for patients with glaucoma. The study included 50 eyes of 32 patients diagnosed with various subtypes of glaucoma for which we performed subliminal transscleral cyclophotocoagulation under retrobulbar anesthesia. After the procedure, all patients were advised to continue their antiglaucoma medication until further notice and we added a topical steroid for 2 weeks. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421491PMC

Influence of learning effect on reliability parameters and global indices of standard automated perimetry in cases of primary open angle glaucoma.

Rom J Ophthalmol 2018 Oct-Dec;62(4):277-281

Department of Ophthalmology, Gajra Raja Medical College, Gwalior, India.

To find out the influence of learning effect on various reliability parameters and global indices of standard automated perimetry in cases of primary open angle glaucoma. Thirty eyes of 30 patients of Primary Open Angle Glaucoma constituted material for this prospective observational study. All the patients underwent standard automated perimetry three times on three different days within one week on G program of Octopus Visual Field Analyzer. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421494PMC
April 2019
1 Read

Transcriptomic and proteomic analysis of iris tissue and aqueous humor in juvenile idiopathic arthritis-associated uveitis.

J Autoimmun 2019 Mar 15. Epub 2019 Mar 15.

Department of Ophthalmology and Ophtha-Lab at St. Franziskus-Hospital, Münster, Germany; Department of Ophthalmology, University of Duisburg-Essen, Essen, Germany.

Gene and protein expression profiles of iris biopsies, aqueous humor (AqH), and sera in patients with juvenile idiopathic arthritis-associated uveitis (JIAU) in comparison to control patients with primary open-angle glaucoma (POAG) and HLA-B27-positive acute anterior uveitis (AAU) were investigated. Via RNA Sequencing (RNA-Seq) and mass spectrometry-based protein expression analyses 136 genes and 56 proteins could be identified as being significantly differentially expressed (DE) between the JIAU and POAG group. Gene expression of different immunoglobulin (Ig) components as well as of the B cell-associated factors ID3, ID1, and EBF1 was significantly upregulated in the JIAU group as compared to POAG patients. Read More

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http://dx.doi.org/10.1016/j.jaut.2019.03.004DOI Listing
March 2019
1 Read