966 results match your criteria Glaucoma Primary Congenital


A Mitomycin C-Sparing Novel Technique for Subscleral Trabeculectomy in Primary Congenital Glaucoma.

J Ophthalmol 2020 7;2020:2017158. Epub 2020 Jun 7.

Ophthalmology Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt.

Purpose: To evaluate the safety and efficacy of a novel modified subscleral trabeculectomy technique in management of primary congenital glaucoma.

Methods: This study included 25 infants diagnosed of having bilateral primary congenital glaucoma. For each patient, one eye was assigned to undergo subscleral trabeculectomy with trimming of the edges of the scleral bed (group I), while the contralateral eye underwent subscleral trabeculectomy with application of mitomycin C (0. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1155/2020/2017158DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7298259PMC

Characteristics of Pediatric Glaucoma in a Latin American Reference Center.

J Curr Glaucoma Pract 2020 Jan-Apr;14(1):10-15

Fundación Oftalmológica Nacional, Bogota, Colombia.

Aim: To describe the clinical and epidemiological characteristics of children with pediatric glaucoma (PG) treated in an ophthalmologic national reference center.

Materials And Methods: A retrospective study of patients diagnosed with PG in a national ophthalmologic reference center was made, between 2005 and 2015. Clinical findings, type of treatment, and the follow-up were evaluated. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5005/jp-journals-10078-1267DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7302610PMC

Descemet's membrane development, structure, function and regeneration.

Exp Eye Res 2020 Jun 6;197:108090. Epub 2020 Jun 6.

Cole Eye Institute, Cleveland Clinic, Cleveland, OH, USA. Electronic address:

Basement membranes are layers of extracellular matrix which anchor the epithelium or endothelium to connective tissues in most organs. Descemet's membrane- which is the basement membrane for the corneal endothelium- is a dense, thick, relatively transparent and cell-free matrix that separates the posterior corneal stroma from the underlying endothelium. It was historically named Descemet's membrane after Jean Descemet, a French physician, but it is also known as the posterior limiting elastic lamina, lamina elastica posterior, and membrane of Demours. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.exer.2020.108090DOI Listing

The Identification and Stereochemistry Analysis of a Novel Mutation p.(D367Tfs*61) in the CYP1B1 Gene: A Case Report.

J Curr Ophthalmol 2020 Jan-Mar;32(1):114-118. Epub 2020 Mar 23.

Department of Medical Genetics, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran.

Purpose: To investigate the presence of a probable genetic defect(s) that may cause primary congenital glaucoma (PCG) in a seven-year-old female patient.

Methods: A seven-year-old female patient and her family received genetic counseling and underwent full clinical examinations by an expert ophthalmologist. The patient's genomic DNA was subjected to the targeted gene capture and next-generation sequencing (NGS) along with Sanger sequencing method. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.joco.2019.09.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7265266PMC

Angle Surgery is the Best Surgical Option for New Patients with Primary Congenital Glaucoma and Not Xen Stent.

J Glaucoma 2020 Jun 2. Epub 2020 Jun 2.

NIHR Biomedical Research Centre at Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/IJG.0000000000001568DOI Listing

Non-Penetrating Deep Sclerectomy versus Trabeculectomy in Primary Congenital Glaucoma.

Clin Ophthalmol 2020 12;14:1277-1285. Epub 2020 May 12.

Ophthalmology Department, Faculty of Medicine, Alexandria University, Alexandria, Egypt.

Purpose: To evaluate the safety and efficacy of non-penetrating deep sclerectomy with a collagen implant versus trabeculectomy in primary congenital glaucoma.

Subjects And Methods: This was a retrospective interventional comparative non-randomized clinical study that included 80 eyes of 80 children presenting with primary congenital glaucoma under the age of 3 years. Forty eyes have undergone non-penetrating deep sclerectomy (NPDS) and the other 40 eyes have undergone penetrating trabeculectomy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2147/OPTH.S253689DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7229790PMC

Baerveldt implant versus trabeculectomy as the first filtering surgery for uncontrolled primary congenital glaucoma: a randomized clinical trial.

Arq Bras Oftalmol 2020 06 29;83(3):215-224. Epub 2020 May 29.

Department of Ophthalmology and Visual Sciences, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, SP, Brazil.

Purpose: Our initial goal was to compare the efficacy and safety of a glaucoma drainage device and trabeculectomy for children with primary congenital glaucoma after angular surgery failure. However, we discontinued the study due to the rate of complications and wrote this report to describe the results obtained with the two techniques in this particular group.

Methods: This was a parallel, non-masked, controlled trial that included patients aged 0-13 years who had undergone previous trabeculotomy or goniotomy and presented inadequately controlled glaucoma with an intraocular pressure ≥21 mmHg on maximum tolerated medical therapy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5935/0004-2749.20200060DOI Listing

Ab externo 240-degree trabeculotomy versus trabeculotomy-trabeculectomy in primary congenital glaucoma.

Int Ophthalmol 2020 Jun 1. Epub 2020 Jun 1.

Ophthalmology Department, Faculty of Medicine, Menofia University, Shebin El Kom, Egypt.

Objective: This prospective study aimed to compare the surgical outcomes of ab externo 240-degree trabeculotomy and trabeculotomy-trabeculectomy in managing primary congenital glaucoma (PCG).

Patients And Methods: The study included 30 eyes of 30 patients aged less than 3 years who were diagnosed with PCG and was conducted in Menofia University Hospital between November 2018 and January 2020. The studied eyes were divided into two equal groups. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10792-020-01453-xDOI Listing

Gonioscopy-assisted transluminal trabeculotomy using an illuminated catheter for infantile primary congenital glaucoma. Case series.

Am J Ophthalmol Case Rep 2020 Sep 8;19:100733. Epub 2020 May 8.

Swiss Eye Centre, Avenue de Rumine 64, 1005, Lausanne, Switzerland.

Purpose: To describe our experience of Gonioscopy-Assisted Transluminal Trabeculotomy (GATT) in four eyes with infantile primary congenital glaucoma (PCG).

Observations: We report the first two GATT procedures performed in six-month-old infants with PCG. We also report the same procedure in two eyes of a two-year-old boy with PCG who had previous goniotomies with subsequent peripheral anterior synechiae formation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ajoc.2020.100733DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7240732PMC
September 2020

Outcomes of Circumferential Trabeculotomy and Converted 180 Degree Traditional Trabeculotomy in Patients with Neonatal-Onset Primary Congenital Glaucoma.

J Glaucoma 2020 May 26. Epub 2020 May 26.

Gazi University School of Medicine, Department of Ophthalmology, Ankara, TURKEY.

PRéCIS:: The present study demonstrates that the surgical success rate of circumferential trabeculotomy is 64.7% according to target IOP ≤21▒mmHg and 30% ≥reduction from baseline in patients with neonatal-onset primary congenital glaucoma, with an average follow-up of 35.1 months. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/IJG.0000000000001559DOI Listing

Five-year results of viscotrabeculotomy versus conventional trabeculotomy in primary congenital glaucoma: A randomized controlled study.

Eur J Ophthalmol 2020 May 26:1120672120922453. Epub 2020 May 26.

Ophthalmology Department, Ophthalmic Center, Faculty of Medicine, Mansoura University, Mansoura, Egypt.

Purpose: To assess the long-term results of viscotrabeculotomy in infants with primary congenital glaucoma and to compare its outcome with conventional trabeculotomy.

Patients And Methods: A prospective randomized comparative study included infants with primary congenital glaucoma younger than 2 years. Patients were divided into two groups: viscotrabeculotomy group and conventional trabeculotomy group. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1120672120922453DOI Listing
May 2020
1.058 Impact Factor

Role of in Primary Congenital Glaucoma and in the Retina: Functional Evaluation in Zebrafish.

Genes (Basel) 2020 May 14;11(5). Epub 2020 May 14.

Área de Genética, Facultad de Medicina de Albacete/Instituto de Investigación en Discapacidades Neurológicas (IDINE), Universidad de Castilla-La Mancha, 02006 Albacete, Spain.

Primary congenital glaucoma (PCG) is a heterogeneous, inherited, and severe optical neuropathy caused by apoptotic degeneration of the retinal ganglion cell layer. Whole-exome sequencing analysis of one PCG family identified two affected siblings who carried a low-frequency homozygous nonsense variant (c.52G > T/p. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/genes11050550DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7288452PMC

An Insight into Primary Congenital Glaucoma.

Crit Rev Eukaryot Gene Expr 2020 ;30(1):39-43

University Institute of Medical Lab Technology, Faculty of Allied Health Sciences, University of Lahore, Lahore, Pakistan.

Glaucoma is the second most prominent cause of impaired vision in the world. Over 60 million individuals are presently affected, and 12 million are sightless as a result. Primary congenital glaucoma (PCG) is a childhood disease that can lead to blindness in newborns and very young children. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1615/CritRevEukaryotGeneExpr.2020027901DOI Listing
January 2020

Outcomes of Ahmed glaucoma valve in paediatric glaucoma following congenital cataract surgery in persistent foetal vasculature.

Eur J Ophthalmol 2020 Apr 30:1120672120919066. Epub 2020 Apr 30.

Hospital Universitario La Paz, Madrid, Spain.

Purpose: To evaluate the outcomes of primary Ahmed glaucoma valve in refractory secondary glaucoma following congenital cataract surgery, particularly in persistent foetal vasculature.

Method: Retrospective review of paediatric patients after Ahmed glaucoma valve implantation for refractory post-lensectomy glaucoma in a tertiary referral centre in Spain. Surgical complications, additional and/or replacements of Ahmed glaucoma valve, intraocular pressure, cup-to-disc ratio, glaucoma medications and final visual acuity were studied. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1120672120919066DOI Listing

Severity of visual field defects in primary congenital glaucoma and their risk factors.

Graefes Arch Clin Exp Ophthalmol 2020 Jul 15;258(7):1483-1491. Epub 2020 Apr 15.

Department of Biostatistics, All India Institute of Medical Sciences, New Delhi, 110029, India.

Purpose: The primary objective of the study was to assess the frequency and severity of visual field defects (VFD) in primary congenital glaucoma (PCG). The secondary objective was to ascertain any associated risk factors.

Methods: An ambispective review of patients with PCG on follow-up with a 'target' intraocular pressure (IOP) of ≤ 15 mmHg. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00417-020-04677-wDOI Listing
July 2020
1.908 Impact Factor

Optical coherence tomography angiography in primary eye care.

Clin Exp Optom 2020 Apr 13. Epub 2020 Apr 13.

Caring Futures Institute, College of Nursing and Health Sciences, Flinders University, Adelaide, Australia.

Optical coherence tomography angiography (OCT-A) is a non-invasive imaging modality for assessing the vasculature within ocular structures including the retina, macula, choroid and optic nerve. OCT-A has a wide range of clinical applications in various optometric conditions which have been independently reported in the literature. This paper aims to present a review of the current literature on the clinical application of OCT-A in optometric practice as well as to analyse and evaluate the quality of the available evidence. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/cxo.13068DOI Listing

CPAMD8 loss-of-function underlies non-dominant congenital glaucoma with variable anterior segment dysgenesis and abnormal extracellular matrix.

Hum Genet 2020 Apr 9. Epub 2020 Apr 9.

Área de Genética, Facultad de Medicina de Albacete, Universidad de Castilla-La Mancha, Albacete, Spain.

Abnormal development of the ocular anterior segment may lead to a spectrum of clinical phenotypes ranging from primary congenital glaucoma (PCG) to variable anterior segment dysgenesis (ASD). The main objective of this study was to identify the genetic alterations underlying recessive congenital glaucoma with ASD (CG-ASD). Next-generation DNA sequencing identified rare biallelic CPAMD8 variants in four patients with CG-ASD and in one case with PCG. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00439-020-02164-0DOI Listing

Spectrum of Genetic Variants Associated with Anterior Segment Dysgenesis in South Florida.

Genes (Basel) 2020 Mar 26;11(4). Epub 2020 Mar 26.

John P. Hussmann Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL 33136, USA.

Anterior segment dysgenesis (ASD) comprises a wide spectrum of developmental conditions affecting the cornea, iris, and lens, which may be associated with abnormalities of other organs. To identify disease-causing variants, we performed exome sequencing in 24 South Florida families with ASD. We identified 12 likely causative variants in 10 families (42%), including single nucleotide or small insertion-deletion variants in B3GLCT, BMP4, CYP1B1, FOXC1, FOXE3, GJA1, PXDN, and TP63, and a large copy number variant involving PAX6. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/genes11040350DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7230952PMC

The Glaucoma Italian Pediatric Study (GIPSy): The Long-term Effect of Topical Latanoprost on Central Corneal Thickness.

J Glaucoma 2020 Jun;29(6):441-447

Section of Ophthalmology, Department of Surgical and Clinical, Diagnostic and Pediatric Sciences, IRCCS Fondazione Policlinico San Matteo, University of Pavia, Pavia, Italy.

Precis: Central corneal thickness (CCT) may increase over time in children affected by primary congenital glaucoma and treated with latanoprost for at least 30 months.

Purpose: The purpose of this study was to investigate CCT modification over time in a population of primary pediatric glaucoma (PPG) patients prescribed a monotherapy of latanoprost.

Materials And Methods: The present paper reports the results of a post hoc analysis on patients enrolled in the Glaucoma Italian Pediatric Study (GIPSy). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/IJG.0000000000001495DOI Listing

A retrospective histologic study of 140 cases of clinically significant equine ocular disorders.

J Vet Diagn Invest 2020 May 24;32(3):382-388. Epub 2020 Mar 24.

Department of Pathobiological Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA (Flores, Del Piero, Langohr).

Ocular diseases are an important category in equine medicine; however, most articles regarding histologic ocular lesions in horses are exclusive to a specific condition and do not provide a complete review of clinically significant ocular disease frequency in a diagnostic laboratory. We reviewed sections of equine eyes from 140 cases (98 enucleations [biopsies] and 42 autopsies) with clinically relevant ocular alterations at 2 diagnostic centers in the United States. The most common primary conditions were non-traumatic keratitis (36), equine recurrent uveitis (ERU; 31), traumatic injuries (22), ocular and periocular neoplasms (19), and uveitis and/or endophthalmitis resulting from sepsis (18). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1040638720912698DOI Listing

Glaucoma as the presenting sign of intraocular tumors: beware of the masquerading sign.

Int Ophthalmol 2020 Jul 20;40(7):1789-1795. Epub 2020 Mar 20.

Ophthalmic Plastic Surgery and Ocular Oncology Services, The Operation Eyesight Universal Institute for Eye Cancer, LV Prasad Eye Institute, Hyderabad, 500034, India.

Purpose: To discuss the clinical presentation and management of intraocular tumors masquerading as primary glaucoma or non-tumor-related secondary glaucoma.

Methods: Retrospective chart review.

Results: Ten patients with unsuspected intraocular tumor were referred to glaucoma clinic with a diagnosis of primary glaucoma or non-tumor-related secondary glaucoma. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10792-020-01348-xDOI Listing

Retinal Pigment Epithelium Cell Density and Bruch's Membrane Thickness in Secondary versus Primary High Myopia and Emmetropia.

Sci Rep 2020 Mar 20;10(1):5159. Epub 2020 Mar 20.

Augenpraxis Jonas, Heidelberg, Germany.

To assess differences between secondary high myopia (SHM) due to congenital glaucoma and primary high myopia (PHM) and non-highly myopic eyes (NHM) in the relationships between axial length and Bruch's membrane (BM) thickness and retinal pigment epithelium (RPE) density. The histomorphometric study included human globes enucleated for reasons such as malignant uveal melanoma, end-stage painful secondary angle-closure glaucoma and congenital glaucoma. BM thickness and RPE cell density were measured upon light microscopy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41598-020-62096-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7083925PMC

Novel mutations in identified in familial cases of primary congenital glaucoma.

Mol Vis 2020 24;26:14-25. Epub 2020 Feb 24.

The Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD.

Purpose: Primary congenital glaucoma (PCG) is a genetically heterogeneous disorder caused by developmental defects in the anterior chamber and trabecular meshwork. This disease is an important cause of childhood blindness. In this study, we aim to identify the genetic determinants of PCG in three consanguineous families of Pakistani descent. Read More

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7043638PMC
February 2020

Causes of congenital corneal opacities and their management in a tertiary care center.

Arq Bras Oftalmol 2020 Mar-Apr;83(2):98-102

Cornea Service, Wills Eye Hospital, Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, USA.

Purpose: To evaluate causes and management of congenital corneal opacities (CCO) diagnosed in a tertiary care eye center and to compare the data with a previous study at the same institution.

Methods: Computerized medical records in all patients with congenital corneal opacities diagnosed in the Cornea Service at Wills Eye Hospital (Philadelphia, PA) between January 1, 2007, and December 31, 2015, were retrospectively reviewed. Children aged 12 years and younger at the first visit were included in the study. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5935/0004-2749.20200023DOI Listing

Maternal diet as a risk factor for primary congenital glaucoma and defects of the anterior segment of the eye in the National Birth Defects Prevention Study.

Birth Defects Res 2020 Apr 10;112(6):503-514. Epub 2020 Mar 10.

Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.

Primary congenital glaucoma (PCG) and anterior segment defects (ASDs) are rare ocular malformations diagnosed early in life which can cause blindness. Pathogenic variants in several genes have been linked to these conditions, but little is known about nongenetic risk factors. We investigated the association between maternal nutrition and PCG and ASDs in the National Birth Defects Prevention Study, a large population-based, multicenter case-control study of major birth defects in the United States. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/bdr2.1664DOI Listing

Investigation of Gene Involvement in Primary Congenital Glaucoma in Iraqi Children.

Middle East Afr J Ophthalmol 2019 Oct-Dec;26(4):203-209. Epub 2020 Jan 29.

Department of Biology, College of Science, University of Anbar, Anbar, Iraq.

Purpose: Primary congenital glaucoma (PCG) is a severe type of glaucoma that occurs early in life. PCG is usually inherited in an autosomal recessive pattern. Cytochrome P450, family 1, subfamily B, polypeptide 1 () gene is reported to be PCG-related gene. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4103/meajo.MEAJO_116_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7034157PMC

Loss of PRSS56 function leads to ocular angle defects and increased susceptibility to high intraocular pressure.

Dis Model Mech 2020 May 29;13(5). Epub 2020 May 29.

Department of Ophthalmology, University of California, San Francisco, CA 94143, USA

Glaucoma is a leading cause of blindness, affecting up to 70 million people worldwide. High intraocular pressure (IOP) is a major risk factor for glaucoma. It is well established that inefficient aqueous humor (AqH) outflow resulting from structural or functional alterations in ocular drainage tissues causes high IOP, but the genes and pathways involved are poorly understood. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1242/dmm.042853DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7272341PMC
May 2020
4.973 Impact Factor

Comparison of visual acuity and complications between primary IOL implantation and aphakia in patients with congenital cataract younger than 2 years: a meta-analysis.

J Cataract Refract Surg 2020 03;46(3):465-473

From the Department of Ophthalmology, Peking University Shenzhen Hospital (J. Chen, Y. Chen, Li), Guangdong, Department of Ophthalmology, Shantou University Medical College (J. Chen), Guangdong, and Eye Center, Second Affiliated Hospital, School of Medicine, Zhejiang University (Zhong), Hangzhou, Zhejiang, China.

To analyze the visual acuity and complications between primary intraocular lens (IOL) implantation and contact lens wearing, this literature search was performed with data on patients with congenital cataract younger than 2 years published in March 2019. Seven identified studies enrolling 675 eyes were selected for analysis. Patients with primary IOL implantation owned better visual acuity than those with aphakia who wore the contact lens (weighted mean difference = 0. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/j.jcrs.0000000000000015DOI Listing

[Clinical practice guidelines for single gene glaucoma disorder].

Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2020 Mar;37(3):329-333

Medical College of University of Electronic Science and Technology, Affiliated Hospital of University of Electronic Science and Technology, Key Laboratory of Human Disease Gene Research, Sichuan Provincial People's Hospital, Chengdu 610072, China.

Glaucoma is a group of progressive optic neuropathies featuring retinal ganglion cell and axonal degeneration, which typically manifest as sunken atrophy of optic papilla and characteristic visual field defect. Genetic factors play an important role in the pathogenesis of glaucoma. This guideline mainly focuses on single gene mutation-related glaucoma by summarizing the pathogenic genes, disease diagnosis and clinical consultation of primary congenital glaucoma (PCG) and primary open-angle glaucoma (POAG), with an aim to regulate their molecular diagnosis, genetic counseling and treatment. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3760/cma.j.issn.1003-9406.2020.03.018DOI Listing

Trabeculotomy versus combined trabeculotomy-trabeculectomy for primary congenital glaucoma: study protocol of a randomised controlled trial.

BMJ Open 2020 02 25;10(2):e032957. Epub 2020 Feb 25.

State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China

Introduction: Trabeculotomy and combined trabeculotomy-trabeculectomy (CTT) are major surgical options for primary congenital glaucoma (PCG). However, it is unclear which of these two surgical procedures should be recommended as the optimum first-line treatment for PCG. This trial aims to determine whether the outcomes of trabeculotomy are non-inferior to those of CTT in moderate PCG with a horizontal corneal diameter (HCD) of 12-14 mm. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bmjopen-2019-032957DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7045219PMC
February 2020
2.063 Impact Factor

[Timing of congenital cataract surgery : Amblyopia versus aphakic glaucoma].

Ophthalmologe 2020 Mar;117(3):190-198

Klinik für Augenheilkunde, Universitätsklinikum der Goethe-Universität, Theodor-Stern-Kai 7, 60590, Frankfurt am Main, Deutschland.

A congenital cataract is a rare disorder, which is associated with a high risk of amblyopia. Ophthalmologists are faced with many diagnostic and surgical challenges in the management of this disease. Older children can undergo primary treatment with an intraocular lens, whereas children younger than 12 months of age usually initially remain aphakic. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00347-020-01053-1DOI Listing

Choroidal neovascular membrane associated with primary congenital glaucoma and buphthalmos.

J AAPOS 2020 Feb 25;24(1):53-56. Epub 2020 Feb 25.

Bascom Palmer Eye Institute, Miami, Florida. Electronic address:

An 18-year-old man with primary congenital glaucoma and buphthalmos in both eyes presented with unilateral, sudden-onset, painless vision loss. He had previously undergone multiple sectoral ab externo rigid-probe trabeculotomy in both eyes and subsequently Baervelt glaucoma implantion in both eyes, with adequate intraocular pressure control. Examination revealed subfoveal choroidal neovascular membrane (CNVM) and associated hemorrhages in the right eye. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jaapos.2019.11.012DOI Listing
February 2020

Primary megalocornea: Case report.

Arch Soc Esp Oftalmol 2020 Apr 11;95(4):201-204. Epub 2020 Feb 11.

Centro Universitario Atenas, Paracatu, Brasil.

The neonate has a horizontal diameter of the cornea, usually up to 10mm with growth up to 2mm in the first 2 years of life. We report a case of megalocornea, a rare, recessive, X-linked disorder in a 3-month-old child, seeking to review what the medical literature brings information about the condition, as well as diagnostic and follow-up parameters, of its main differential diagnoses. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.oftal.2019.12.016DOI Listing

Disease-related and age-related changes of anterior chamber angle structures in patients with primary congenital glaucoma: An in vivo high-frequency ultrasound biomicroscopy-based study.

PLoS One 2020 28;15(1):e0227602. Epub 2020 Jan 28.

Beijing Tongren Eye Center, Beijing Tongren Hospital, Beijing Institute of Ophthalmology, Capital Medical University, Beijing, China.

Objectives: To provide in vivo measurements of anterior chamber angle structures and their relationship with age as evaluated by high-frequency ultrasound biomicroscopy (UBM) in patients with primary congenital glaucoma (PCG).

Methods: High-frequency UBM was done for 51 PCG eyes from 40 patients (aged from 3 to 96 months) and 11 unaffected contralateral eyes. Parameters, including the proportion of observable abnormal tissue membrane and Schlemm's canal, the largest cross-sectional area (CSA) of Schlemm's canal (SC), SC meridional diameter, trabecular-iris angle (TIA), trabecular meshwork (TM) thickness, iris thickness, ciliary process length, and corneal limbus thickness were compared between the two groups and their relationship with age was explored in PCG eyes. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0227602PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6986727PMC
April 2020
3.234 Impact Factor

XEN Gel Stent in Pediatric Glaucoma.

J Glaucoma 2020 Apr;29(4):e19-e22

Glaucoma Associates of Texas, Dallas, TX.

Purpose: To report a series of 3 eyes of 3 children with congenital glaucoma receiving the XEN gel stent implant.

Patients And Methods: An interventional case series is reported.

Results: Three eyes underwent implantation of the gel stent. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/IJG.0000000000001453DOI Listing

Outcomes of Bilateral Cataracts Removed in Infants 1 to 7 Months of Age Using the Toddler Aphakia and Pseudophakia Treatment Study Registry.

Ophthalmology 2020 04 9;127(4):501-510. Epub 2019 Nov 9.

Department of Ophthalmology, Emory University School of Medicine, Atlanta, Georgia; Departments of Ophthalmology and Pediatrics, Stanford University School of Medicine, Palo Alto, California.

Purpose: To evaluate outcomes of bilateral cataract surgery in infants 1 to 7 months of age performed by Infant Aphakia Treatment Study (IATS) investigators during IATS recruitment and to compare them with IATS unilateral outcomes.

Design: Retrospective case series review at 10 IATS sites.

Participants: The Toddler Aphakia and Pseudophakia Study (TAPS) is a registry of children treated by surgeons who participated in the IATS. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ophtha.2019.10.039DOI Listing

Ahmed Valve Tube Extension in Pediatric Glaucoma.

J Glaucoma 2020 Apr;29(4):276-279

Pediatric Ophthalmology Department, Children's Hospital of Michigan, Detroit, MI.

PRéCIS:: Ahmed valve tube extender showed good long-term outcomes for retracted tubes in pediatric glaucoma. The procedure is safe with limited complications.

Purpose: To analyze the long-term outcomes of Ahmed valve tube extension in pediatric glaucoma patients. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/IJG.0000000000001446DOI Listing

Chromosome 1q Terminal Deletion and Congenital Glaucoma: A Case Report.

Am J Case Rep 2020 Jan 12;21:e918128. Epub 2020 Jan 12.

College of Medicine, Alfaisal University, Riyadh, Saudi Arabia.

BACKGROUND This paper aims to highlight the presence of primary congenital glaucoma (PCG) in a patient with chromosome 1 q31 and q42.1 deletion of the distal long arm. The characteristic combination of phenotypic features in this deletion include dysmorphic features, psychomotor retardation and neurological signs; however, PCG has never been recognized as part of these features before. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.12659/AJCR.918128DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6977633PMC
January 2020

Retinal capillary hemangioblastoma and hemiretinal vein occlusion in a patient with primary congenital glaucoma: A case report.

Saudi J Ophthalmol 2019 Oct-Dec;33(4):401-404. Epub 2018 Dec 8.

Vitreoretinal Division, King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia.

The presence of retinal capillary hemangioblastoma and cerebellar hemangioblastoma in the context of Von Hippel-Lindau syndrome (VHL) is not characteristically associated with other ophthalmologic conditions. Here, we report the case of a 22-yearold female with a history of bilateral primary congenital glaucoma who presented with a right juxtapapillary retinal capillary hemangioblastoma and an old hemiretinal vein occlusion in which the retinal capillary hemangioblastoma was likely the contributing factor. Her systemic work up was positive for VHL syndrome and revealed the presence of a fatal large brainstem hemangioblastoma. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.sjopt.2018.11.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6950941PMC
December 2018

Primary congenital glaucoma: An updated review.

Saudi J Ophthalmol 2019 Oct-Dec;33(4):382-388. Epub 2019 Nov 7.

King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia.

Primary congenital glaucoma (PCG) is a rare disease affecting children early in life. PCG was considered untreatable with inevitable blindness. However, recent advances in biochemical and genetic studies, the introduction of new diagnostic tools, intraocular pressure (IOP) lowering medications and improvement of surgical techniques have led to a better understanding of this devastating disease and preserving the vision of affected children. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.sjopt.2019.10.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6950954PMC
November 2019

Update in Genetics and Surgical Management of Primary Congenital Glaucoma

Turk J Ophthalmol 2019 12;49(6):347-355

University of Illinois at Chicago, Department of Ophthalmology and Visual Sciences, Chicago, USA

Primary congenital glaucoma (PCG) continues to be an important cause of visual impairment in children despite advances in medical and surgical treatment options. The progressive and blinding nature of the disease, together with the long lifespan of the affected population, necessitates a thorough understanding of the pathophysiology of PCG and the development of long-lasting treatment options. The first part of this review discusses the genetic features and makeup of this disorder, including all currently identified genetic loci (GLC3A, GLC3B, GLC3C and GLC3D) and relevant protein targets important for trabecular and Schlemm canal dysgenesis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4274/tjo.galenos.2019.28828DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6961078PMC
December 2019

Primary Pediatric Keratoplasty: Etiology, Graft Survival, and Visual Outcome.

Am J Ophthalmol 2020 04 25;212:162-168. Epub 2019 Dec 25.

Department of Ophthalmology and Visual Sciences, Paulista School of Medicine, São Paulo Hospital, Federal University of São Paulo - UNIFESP, São Paulo, Brazil.

Purpose: Interventional study to evaluate the etiology, visual outcome and survival of corneal transplantation in children and to identify the risk factors associated with graft failure.

Design: Retrospective, interventional consecutive case series.

Methods: Medical records of every child 7 years of age or younger who underwent primary penetrating keratoplasty at Department of Ophthalmology, Federal University of São Paulo were reviewed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ajo.2019.12.013DOI Listing

Long-term functional outcomes of different subtypes of primary congenital glaucoma.

Br J Ophthalmol 2019 Dec 23. Epub 2019 Dec 23.

Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All india Institute of Medical Sciences, New Delhi, India

Aim: To analyse long-term visual outcomes across different subtypes of primary congenital glaucoma (PCG).

Methods: Patients with PCG with a minimum of 5-year follow-up post surgery were included in the study. Snellen visual acuity recordings taken at their last follow-up were analysed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bjophthalmol-2019-315131DOI Listing
December 2019
2.976 Impact Factor

Rate of Complete Catheterization of Schlemm's Canal and Trabeculotomy Success in Primary and Secondary Childhood Glaucomas.

Am J Ophthalmol 2020 04 11;212:69-78. Epub 2019 Dec 11.

Department of Ophthalmology and Visual Sciences, Kellogg Eye Center, University of Michigan, Ann Arbor, Michigan, USA. Electronic address:

Purpose: Despite the increasing use of microcatheters to perform 360-degree trabeculotomy, the rate of complete Schlemm's canalization in different forms of pediatric glaucoma is under-reported.

Design: Retrospective institutional observational case series.

Methods: Ocular diagnoses and surgical details of 60 pediatric patients (≤18 years old) who underwent trabeculotomy between 2013 and 2019 were collected. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ajo.2019.11.029DOI Listing

Viscocanalostomy combined with nearly 360-degree suture trabeculotomy for the treatment of primary congenital glaucoma: a preliminary report of a novel technique for trabeculotomy.

Graefes Arch Clin Exp Ophthalmol 2020 Feb 30;258(2):379-386. Epub 2019 Nov 30.

Department of Ophthalmology, The First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing, 210029, China.

Purpose: The aim of this study was to determine the preliminary efficacy and safety of a novel technique for trabeculotomy for the treatment of primary congenital glaucoma (PCG).

Methods: This retrospective interventional study was conducted on patients with PCG. Pliability test was performed among 5/0 and 6/0 polypropylene sutures and the flexible illuminated microcatheter. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00417-019-04537-2DOI Listing
February 2020

Successful Treatment of Corneal Opacification with Associated Thickened Epithelium by Simple Peeling: Acquired Corneal Subepithelial Hypertrophy (ACSH).

Saudi J Ophthalmol 2019 Jul-Sep;33(3):203-208. Epub 2019 Feb 13.

Specialized Experts Center, Riyadh, Saudi Arabia.

Purpose: To study clinical and histopathological findings of corneal opacification caused by thickened epithelium leading to reduced vision and topographical changes and to evaluate the outcome of its removal.

Methods: Twelve patients (17 eyes) with central, paracentral or peripheral corneal opacification were reviewed to obtain their visual acuity, describe their slit lamp (SL) appearance (depth, extent and density) and document their topographic changes before and after peeling of the epithelium under SL or surgical removal under the microscope. Specimens of six cases were available for histopathological examination and immunohistochemical staining. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.sjopt.2019.02.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6819717PMC
February 2019

Primary congenital glaucoma in Denmark, 1977-2016.

Acta Ophthalmol 2020 Mar 30;98(2):182-189. Epub 2019 Oct 30.

Department of Ophthalmology, University Hospital of Copenhagen, Rigshospitalet-Glostrup, Glostrup, Denmark.

Purpose: To perform an epidemiological survey of all patients in Denmark diagnosed with primary congenital glaucoma (PCG) from 1977 to 2016.

Methods: A retrospective, nationwide study based on a review of medical files of all children with PCG born in Denmark from 1977 to 2016. PCG was defined as glaucoma due to isolated angle dysgenesis affecting children from birth and including late onset/late recognized PCG, excluding glaucoma associated with other congenital abnormalities. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/aos.14207DOI Listing

Trabeculotomy Ab Interno With the Trab360 Device for Childhood Glaucomas.

Am J Ophthalmol 2020 01 21;209:178-186. Epub 2019 Oct 21.

Department of Ophthalmology, Mayo Clinic, Rochester, Minnesota, USA.

Purpose: To report outcomes and complications of trabeculotomy ab interno using the Trab360 device (Trab360; Sight Sciences, Menlo Park, California, USA) in eyes with childhood glaucomas.

Design: Multicenter retrospective interventional case series.

Methods: Eyes with childhood glaucomas that underwent Trab360 with at least 3 months follow-up were evaluated. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ajo.2019.10.014DOI Listing
January 2020
1 Read