875 results match your criteria Glaucoma Primary Congenital


Cataract extraction in patients with primary congenital glaucoma.

Eur J Ophthalmol 2019 Apr 7:1120672119841190. Epub 2019 Apr 7.

1 Ophthalmology Department, Clínico San Carlos Hospital, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Madrid, Spain.

Objective: To assess incidence and risk factors of cataract extraction in patients with primary congenital glaucoma, surgical outcome, and complications.

Material And Method: Retrospective cohort study, in which 108 patients with primary congenital glaucoma were included. Data collected were need for cataract extraction and at what age, intraocular pressure at diagnosis of primary congenital glaucoma, required antiglaucomatous surgeries, possible mutation in the CYP1B1 gene, and final visual acuity. Read More

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http://journals.sagepub.com/doi/10.1177/1120672119841190
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http://dx.doi.org/10.1177/1120672119841190DOI Listing
April 2019
7 Reads

Congenital Rubella Syndrome in The African Region - Data from Sentinel Surveillance.

J Immunol Sci 2018 Aug;Suppl:146-150

WHO Regional Office for Africa. Brazzaville, Congo.

Introduction: Rubella is a mild febrile rash illness caused by the rubella virus. The most serious consequence of rubella is congenital rubella syndrome (CRS), which occurs if the primary rubella infection occurs during early pregnancy, with subsequent infection of the placenta and the developing fetus.

Methods: WHO supported countries to set up sentinel surveillance for CRS using standard case definitions, protocols, and case classification scheme. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446990PMC

Differences in retinal nerve fiber layer thickness measured by spectral domain optical coherence tomography between primary congenital glaucoma patients and healthy children.

J AAPOS 2019 Apr 2. Epub 2019 Apr 2.

Professor and Chairman. Ophthalmology Department. Clinico San Carlos Universitary Hospital, Sanitary Research Institute of the San Carlos Clinical Hospital, Madrid, Spain; Ocular Pathology National Net OFTARED of the Institute of Health Carlos III, Profesor Martín Lagos Street, 28040, Madrid, Spain, Universidad Complutense. Madrid, Spain. Electronic address:

Purpose: To evaluate the retinal nerve fiber layer (RNFL) thickness using spectral domain optical coherence tomography (SD-OCT) in a population of children diagnosed with primary congenital glaucoma (PCG).

Methods: Cross-sectional study where 59 eyes from 59 children diagnosed with PCG and 87 eyes from 87 healthy children were evaluated by SD-OCT to measure the RNFL. The global average peripapillary RNFL thickness and sectional RNFL thickness were evaluated in both groups. Read More

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http://dx.doi.org/10.1016/j.jaapos.2017.03.023DOI Listing
April 2019
1 Read

Prevalence and Clinical Characteristics of Childhood Glaucoma at A Tertiary Care Children's Hospital.

J Glaucoma 2019 Apr 3. Epub 2019 Apr 3.

Akron Children's Hospital, Akron OH.

Precis: Glaucoma suspect was the most prevalent category in this study followed by glaucoma associated with acquired ocular anomaly and juvenile open-angle glaucoma. Primary congenital glaucoma was diagnosed in only 3% of the population studied.

Purpose: To describe the prevalence and clinical characteristics of childhood glaucoma diagnosed over a 10-year period among patients ≤18 years of age who were seen at a tertiary care children's hospital using the new Childhood Glaucoma Research Network (CGRN) classification system. Read More

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http://dx.doi.org/10.1097/IJG.0000000000001259DOI Listing

Early results of micropulse transscleral cyclophotocoagulation for the treatment of glaucoma.

Eur J Ophthalmol 2019 Apr 2:1120672119839303. Epub 2019 Apr 2.

1 Department of Ophthalmology and Visual Science, Yale School of Medicine, New Haven, CT, USA.

Purpose:: To describe our clinical experience with the efficacy and safety of micropulse transscleral cyclophotocoagulation as a treatment for glaucoma.

Methods:: In this retrospective case series, we reviewed the charts of 95 consecutive patients with various glaucoma subtypes who underwent micropulse transscleral cyclophotocoagulation. Patients were offered micropulse transscleral cyclophotocoagulation if they had perimetric glaucoma refractory to intraocular pressure-lowering topical medications and who were poor candidates for traditional filtering surgery. Read More

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http://dx.doi.org/10.1177/1120672119839303DOI Listing
April 2019
13 Reads

The role of primary intraocular lens implantation in the risk of secondary glaucoma following congenital cataract surgery: A systematic review and meta-analysis.

PLoS One 2019 1;14(4):e0214684. Epub 2019 Apr 1.

Department of Ophthalmology, Xiangya Hospital, Central South University, Changsha, Hunan, China.

Objective: This meta-analysis aims to evaluate the incidence of secondary glaucoma in patients under the age of 2 years who underwent congenital cataract surgery with or without primary intraocular lens (IOL) implantation.

Methods: An electronic literature search was performed in Medline, EMBASE, and Web of Science databases to retrieve studies between January 2011 and November 2018. Patients with congenital cataract who did primary IOL implantation, aphakia, or secondary IOL implantation followed by receiving extraction surgery were included in this study. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0214684PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443152PMC

Risk factors and outcomes of management of delayed suprachoroidal haemorrhage following Ahmed glaucoma valve implantation in children.

Br J Ophthalmol 2019 Mar 28. Epub 2019 Mar 28.

Smt Jadhavabhai Nathmal Singhvee Glaucoma Services, Medical Research Foundation, Sankara Nethralaya, Chennai, India.

Aims: To assess the incidence, risk factors and outcomes of management of delayed suprachoroidal haemorrhage (DSCH) in children who had undergone Ahmed glaucoma valve implantation.

Methods: A retrospective case-control study of eyes which developed DSCH in children <18 years of age who underwent surgery between January 2009 and December 2017 with a follow-up of at least 2 months was performed. Nine cases were compared with 27 age, gender and surgeon matched controls who had undergone surgery during this period. Read More

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http://dx.doi.org/10.1136/bjophthalmol-2018-313804DOI Listing
March 2019
2 Reads

Glaucoma in Congenital Zika Syndrome.

J Glaucoma 2019 Mar 26. Epub 2019 Mar 26.

Honorary professor, dr DY Patil University, Pune, India.

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http://dx.doi.org/10.1097/IJG.0000000000001252DOI Listing

Endoscopic cyclophotocoagulation (ECP) for childhood glaucoma: a large single-center cohort experience.

J AAPOS 2019 Mar 16. Epub 2019 Mar 16.

Duke University Department of Ophthalmology, Durham, North Carolina. Electronic address:

Purpose: To assess the factors associated with successful outcomes in the management of childhood glaucoma treated with endoscopic cyclophotocoagulation (ECP) as both primary and adjunctive surgery.

Methods: The medical records of consecutive children with glaucoma treated by a single surgeon at a single center over a 17-year period using ECP procedures were reviewed retrospectively. Treatment failure was defined as (1) intraocular pressure (IOP) >24 mm Hg at two consecutive examinations despite maximal medical treatment, (2) any additional glaucoma surgery, (3) sight-threatening complications, or (4) progression to no light perception visual acuity. Read More

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http://dx.doi.org/10.1016/j.jaapos.2018.10.014DOI Listing
March 2019
1 Read

Assessment of the anterior segment of patients with primary congenital glaucoma using handheld optical coherence tomography.

Eye (Lond) 2019 Mar 18. Epub 2019 Mar 18.

Ophthalmology Group, University of Leicester, Leicester, UK.

Purpose: To investigate the potential of handheld optical coherence tomography (HH-OCT) in assessing the anterior segment of the eye in patients with primary congenital glaucoma.

Design: A prospective, case-controlled observational study.

Participants: Twenty-two patients with primary congenital glaucoma (PCG, 9 females and 13 males; mean age 4. Read More

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http://dx.doi.org/10.1038/s41433-019-0369-3DOI Listing

Reactivation of spontaneously resolved primary congenital glaucoma: A rare case report.

J Fr Ophtalmol 2019 Apr 7;42(4):e185-e186. Epub 2019 Mar 7.

Department A, Institute Hedi Rais of Ophthalmology, Faculty of Medicine of Tunis, University Tunis El Manar, Tunis, Tunisia. Electronic address:

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http://dx.doi.org/10.1016/j.jfo.2018.07.013DOI Listing

Factors influencing the outcome of goniotomy and trabeculotomy in primary congenital glaucoma.

Br J Ophthalmol 2019 Mar 7. Epub 2019 Mar 7.

Ophthalmology department, Kasr Al Ainy Faculty of Medicine, Cairo University, Cairo, Egypt.

Purpose: To study the prognostic factors influencing intraocular pressure (IOP) reduction and success rates of paediatric goniotomy and trabeculotomy.

Patients: Data from patients aged ≤12 years who underwent goniotomy or trabeculotomy for primary congenital glaucoma from 2013 to 2016 were reviewed. The analysis included 452 eyes of which 120 eyes of patients with a median age (IQR) of 6 months (4. Read More

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http://dx.doi.org/10.1136/bjophthalmol-2018-313387DOI Listing
March 2019
1 Read

Identities and frequencies of variants in causing primary congenital glaucoma in Pakistan.

Mol Vis 2019 22;25:144-154. Epub 2019 Feb 22.

Department of Otorhinolaryngology Head and Neck Surgery, School of Medicine, University of Maryland, Baltimore, MD.

Purpose: Primary congenital glaucoma (PCG) is a clinically and genetically heterogeneous disease. The present study was undertaken to find the genetic causes of PCG segregating in 36 large consanguineous Pakistani families.

Methods: Ophthalmic examination including fundoscopy, or slit-lamp microscopy was performed to clinically characterize the PCG phenotype. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6386514PMC
February 2019
2 Reads
1.986 Impact Factor

Launching a paradigm for first and redo-surgery in primary congenital glaucoma: institutional experience.

Int J Ophthalmol 2019 18;12(2):226-234. Epub 2019 Feb 18.

Mansoura Ophthalmic Center, Faculty of Medicine, Mansoura University, Mansoura 35516, Egypt.

Aim: To evaluate the outcome of the initial and the redo-surgeries for primary congenital glaucoma (PCG) correlated to its degree of severity.

Methods: A retrospective study involved patients with PCG presented between 2010 and 2018. Medical records were reviewed to assess the degree of the preoperative severity according to the intraocular pressure (IOP), corneal diameter and corneal edema. Read More

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http://dx.doi.org/10.18240/ijo.2019.02.07DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6376225PMC
February 2019
1 Read

Screening of Arg368His as predominant mutation in North Indian primary open angle glaucoma and juvenile onset glaucoma patients.

Mol Biol Res Commun 2018 Dec;7(4):181-186

Department of Human Genetics, Guru Nanak Dev University, Amritsar 143005, India.

In India, mutations in Cytochrome P450 () are a predominant cause of not only primary congenital glaucoma (PCG) but also involved in primary open angle glaucoma (POAG) and juvenile onset glaucoma (JOAG). After ethical clearance, 100 POAG patients, 30 primary angle closure glaucoma (PACG) patients and 130 ethnically matched controls were recruited in this study. Genomic DNA was isolated from the blood and screened for p. Read More

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http://dx.doi.org/10.22099/mbrc.2018.30630.1344DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363938PMC
December 2018

Profile of childhood glaucoma at a tertiary center in South India.

Indian J Ophthalmol 2019 Mar;67(3):358-365

VST Glaucoma Center, L V Prasad Eye Institute, Banjara Hills, Hyderabad, Telangana, India.

Purpose: To describe the prevalence of various types of childhood glaucomas, their clinical features and treatment methods.

Methods: We prospectively included consecutive children with glaucoma presenting to glaucoma clinic for the first time between March 2013 and May 2014. We classified childhood glaucomas as per the classification proposed by Congenital Glaucoma Research Network. Read More

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http://dx.doi.org/10.4103/ijo.IJO_786_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6407385PMC

Congenital Refractory Glaucoma: a New Ophthalmic Association of Kabuki Syndrome and its Management with Glaucoma Drainage Devices.

J Glaucoma 2019 Jan 22. Epub 2019 Jan 22.

Glaucoma Research Center, Montchoisi Clinic, Swiss Visio Network, Lausanne, Switzerland.

Introduction: Kabuki syndrome (KS) is a rare congenital and polymalformative condition, traditionally associated with mental retardation, unusual facial features and skeletal abnormalities. We hereby describe a case of bilateral congenital glaucoma associated with MLL2-mutation Kabuki Syndrome. To the best of our knowledge, this is the first association of KS with congenital glaucoma. Read More

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http://dx.doi.org/10.1097/IJG.0000000000001201DOI Listing
January 2019
1 Read

Two novel variants in gene: a major contributor of autosomal recessive primary congenital glaucoma with allelic heterogeneity in Pakistani patients.

Int J Ophthalmol 2019 18;12(1):8-15. Epub 2019 Jan 18.

Molecular Biology and Genetics Department, Liaquat University of Medical and Health Sciences, Jamshoro, Sindh 76090, Pakistan.

Aim: To find the mutations associated with primary congenital glaucoma (PCG) in Pakistani consanguineous pedigrees.

Methods: After getting informed consent, 11 consanguineous pedigrees belonging to different ethnic groups were enrolled. Detailed medical history was recorded and pedigrees were drawn. Read More

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http://www.ijo.cn/gjyken/ch/reader/view_abstract.aspx?file_n
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http://dx.doi.org/10.18240/ijo.2019.01.02DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6326927PMC
January 2019
15 Reads
0.500 Impact Factor

Prevalence of FOXC1 Variants in Individuals With a Suspected Diagnosis of Primary Congenital Glaucoma.

JAMA Ophthalmol 2019 Jan 17. Epub 2019 Jan 17.

Department of Ophthalmology, Flinders University, Flinders Medical Centre, Adelaide, Australia.

Importance: Both primary and secondary forms of childhood glaucoma have many distinct causative mechanisms, and in many cases a cause is not immediately clear. The broad phenotypic spectrum of secondary glaucoma, particularly in individuals with variants in FOXC1 or PITX2 genes associated with Axenfeld-Rieger syndrome, makes it more difficult to diagnose patients with milder phenotypes. These cases are occasionally classified and managed as primary congenital glaucoma. Read More

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http://archopht.jamanetwork.com/article.aspx?doi=10.1001/jam
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http://dx.doi.org/10.1001/jamaophthalmol.2018.5646DOI Listing
January 2019
10 Reads

LTBP2-related "Marfan-like" phenotype in two Roma/Gypsy subjects with the LTBP2 homozygous p.R299X variant.

Am J Med Genet A 2019 Jan 18;179(1):104-112. Epub 2018 Dec 18.

Pediatric Cardiology and Arrhythmology Unit, Department of Pediatric Cardiology and Cardiac Surgery, IRCCS-Bambino Gesù Children Hospital and Research Institute, Rome, Italy.

Recessive variants in LTBP2 are associated with eye-restricted phenotypes including (a) primary congenital glaucoma and (b) microspherophakia/megalocornea and ectopia lentis with/without secondary glaucoma. Nosology of LTBP2 pathology in humans is apparently in contrast with the consolidated evidence of a wide expression of this gene in the developing embryo. Accordingly, in previously published patients with LTBP2-related eye disease, additional extraocular findings have been occasionally reported and include, among others, high-arched palate, tall stature, and variable cardiac involvement. Read More

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http://doi.wiley.com/10.1002/ajmg.a.10
Publisher Site
http://dx.doi.org/10.1002/ajmg.a.10DOI Listing
January 2019
20 Reads

Haab striae: Optical coherence tomographic analysis.

J Fr Ophtalmol 2019 Jan 13;42(1):11-15. Epub 2018 Dec 13.

Servicio de Oftalmología, Hospital Clínico San Carlos, Madrid, Spain.

Purpose: To study Haab striae in adults with primary congenital glaucoma and describe them by anterior segment optical coherence tomography, as well as analyze their evolution over the patient's lifetime.

Material And Methods: Three patients with primary congenital glaucoma were recruited, aged between 17 and 48 years old, with incidentally noted Haab striae on glaucoma consultation. They were studied by: slit lamp; anterior segment optical coherence tomography, Heidelberg Engineering Inc. Read More

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http://dx.doi.org/10.1016/j.jfo.2018.05.007DOI Listing
January 2019

Ahmed Glaucoma Valve Revision Versus Visco-Trabeculotomy After Failed Ahmed Glaucoma Valve in Refractory Pediatric Glaucoma.

J Glaucoma 2019 Apr;28(4):307-312

Department of Ophthalmology, Faculty of Medicine, Alexandria University, Alexandria, Egypt.

Purpose: To compare the outcome of the intraocular pressure (IOP) of Ahmed glaucoma valve (AGV) revision to visco-trabeculotomy (VT) in children's eyes with failed AGV.

Patients And Methods: A prospective randomized study conducted on 41 children (41 eyes) with uncontrolled glaucoma with an AGV presenting to the pediatric ophthalmology clinic of Mansoura Ophthalmic Center between 2011 and 2016. Study eyes were randomized to AGV revision or VT. Read More

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http://dx.doi.org/10.1097/IJG.0000000000001149DOI Listing
April 2019
4 Reads
2.427 Impact Factor

CYP1B1 Gene and Phenotypic Correlation in Patients From Northeastern Brazil With Primary Congenital Glaucoma.

J Glaucoma 2019 Feb;28(2):161-164

Hospital das Clínicas, Federal University of Pernambuco (HC-UFPE).

Purpose: To identify variants in the CYP1B1 gene in northeastern Brazilian patients with primary congenital glaucoma (PCG) and possible genotype-phenotype correlations.

Materials And Methods: This is a cross-sectional observational study of 17 nonrelated patients with PCG, performed at the Altino Ventura Foundation, Recife, Brazil, between December 2017 and February 2018. All patients underwent an examination, including gathering information from their medical records, slit-lamp examination, fundoscopy, tonography, and measuring corneal diameter and thickness. Read More

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http://dx.doi.org/10.1097/IJG.0000000000001132DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358192PMC
February 2019
2 Reads

Quality of life following surgery for congenital glaucoma: findings of the LVPEI congenital glaucoma registry.

Eye (Lond) 2019 Apr 5;33(4):659-667. Epub 2018 Dec 5.

Jasti V Ramanamma Children's Eye Care Centre, L V Prasad Eye Institute, Hyderabad, India.

Purpose: To evaluate the health-related quality of life (HRQoL) of children operated for primary congenital glaucoma (PCG) using the Kidscreen-27 questionnaire.

Methods: A total of 121 children (mean age, 11.8 years; SD, 2. Read More

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http://dx.doi.org/10.1038/s41433-018-0293-yDOI Listing
April 2019
4 Reads

Pigmented lesion in the anterior chamber angle following multiple trans-scleral diode laser photocoagulation for congenital glaucoma.

Am J Ophthalmol Case Rep 2019 Mar 14;13:32-33. Epub 2018 Nov 14.

King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia.

Purpose: To describe a child with primary congenital glaucoma found to have pigment tissue proliferation in the angle following multiple applications of trans-scleral cyclophotocoagulation.

Observations: During examination under anaesthesia, a 4-year-old girl was found to have pigmented tissue overlying the trabecular meshwork. Anterior segment ocular coherence tomography confirmed mounds of abnormal tissue in the angle. Read More

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http://dx.doi.org/10.1016/j.ajoc.2018.11.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6257925PMC
March 2019
1 Read

P.Gly61Glu and P.Arg368His Mutations in CYP1B1 that Cause Congenital Glaucoma may be Relatively Frequent in Certain Regions of Gilan Province, Iran.

J Ophthalmic Vis Res 2018 Oct-Dec;13(4):403-410

Department of Biotechnology, College of Science, University of Tehran, Tehran, Iran.

Purpose: To perform a population-based screening of four mutations-p.Gly61Glu, p.Arg368His, p. Read More

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http://dx.doi.org/10.4103/jovr.jovr_147_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6210879PMC
November 2018

Targeted Screening for Predominant CYP1B1 Mutations in Primary Congenital Glaucoma.

J Ophthalmic Vis Res 2018 Oct-Dec;13(4):373-375

Department of Surgery, Molecular Ophthalmic Genetics Laboratory, UConn Health, Farmington, CT, USA.

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http://dx.doi.org/10.4103/jovr.jovr_232_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6210886PMC
November 2018

Clinical Presentation and Management Outcomes of Coexistent Congenital Glaucoma and Retinopathy of Prematurity.

J Glaucoma 2019 Jan;28(1):20-26

Jasti V Ramanamma Children's Eye Care Center.

Purpose: The purpose of this study was to report presentation and outcomes of coexisting congenital glaucoma with retinopathy of prematurity (ROP) in "Indian Twin cities ROP study (ITCROPS)."

Methods: Children with ROP and congenital glaucoma were identified from ITCROPS (prospective digital database) between 1997 and 2016. The presentation, interventions, and outcomes for glaucoma and ROP were evaluated. Read More

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http://dx.doi.org/10.1097/IJG.0000000000001124DOI Listing
January 2019
4 Reads

Systemic Associations of Childhood Glaucoma: A Review.

J Pediatr Ophthalmol Strabismus 2018 Nov;55(6):397-402

Purpose: To review systemic associations of childhood glaucoma.

Methods: Patients younger than 15 years and diagnosed as having glaucoma were divided into four groups: isolated primary congenital glaucoma, glaucoma with other congenital ocular anomalies, congenital glaucoma with known systemic diseases, and secondary glaucoma. Prevalence and type of systemic associations in each group were studied. Read More

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https://www.healio.com/doiresolver?doi=10.3928/01913913-2018
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http://dx.doi.org/10.3928/01913913-20180905-01DOI Listing
November 2018
11 Reads
0.731 Impact Factor

Quality of life and visual function in children with glaucoma in Spain.

Arch Soc Esp Oftalmol 2019 Mar 13;94(3):119-124. Epub 2018 Nov 13.

Unidad de Glaucoma, Servicio de Oftalmología, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Madrid, España.

Objective: To evaluate the effect of glaucoma on visual function, as well as quality of life in children and quality of life perceived by caregivers in children up to 16 years of age.

Material And Methods: An observational and prospective study was designed using the questionnaire GQL-15 (Glaucoma Quality of Life) and conducted on children and caregivers. The questionnaire VFQ-25 (Visual Functioning Questionnaire) was conducted on children. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03656691183027
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http://dx.doi.org/10.1016/j.oftal.2018.09.001DOI Listing
March 2019
6 Reads

5-year outcomes after primary intraocular lens implantation in children aged 2 years or younger with congenital or infantile cataract: findings from the IoLunder2 prospective inception cohort study.

Lancet Child Adolesc Health 2018 Dec 31;2(12):863-871. Epub 2018 Oct 31.

Life Course Epidemiology and Biostatistics Section, UCL Great Ormond Street Institute of Child Health, University College London, London, UK; UCL Institute of Ophthalmology, University College London, London, UK; Great Ormond Street Hospital NHS Foundation Trust, London, UK; NIHR Moorfields Eye Hospital Biomedical Research Centre, London, UK; Moorfields Eye Hospital NHS Foundation Trust, London, UK; NIHR Great Ormond Street Hospital Biomedical Research Centre, London, UK. Electronic address:

Background: International initiatives to prevent childhood blindness have highlighted the importance of early, effective intervention for congenital and infantile cataract. In the UK, intraocular lens implantation has been widely adopted by surgeons to treat these conditions. However, evidence about the benefits and risks of this technique in different age groups is limited. Read More

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http://dx.doi.org/10.1016/S2352-4642(18)30317-1DOI Listing
December 2018
1 Read

Refractive outcomes of cataract surgery in primary congenital glaucoma.

Eye (Lond) 2019 Apr 31;33(4):542-548. Epub 2018 Oct 31.

Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India.

Aim: To evaluate refractive outcomes of cataract surgery with intraocular lens (IOL) implantation in operated eyes of primary congenital glaucoma (PCG).

Design: A retrospective case-control study.

Methods: Patients of PCG who developed cataract following trabeculectomy with trabeculotomy were recruited. Read More

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http://www.nature.com/articles/s41433-018-0253-6
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http://dx.doi.org/10.1038/s41433-018-0253-6DOI Listing
April 2019
2 Reads

Microcatheter-assisted Trabeculotomy for Primary Congenital Glaucoma After Failed Glaucoma Surgeries.

J Glaucoma 2019 Jan;28(1):1-6

Beijing Tongren Eye Center, Beijing Tongren Hospital.

Purpose: To evaluate the effectiveness of microcatheter-assisted trabeculotomy (MAT) to treat primary congenital glaucoma after failed previous glaucoma surgeries.

Materials And Methods: Retrospective, noncomparative, interventional case series conducted at Beijing Tongren Eye Center, China. Outcome measures were compared between 3 groups: successful and complete (≥330 degrees) MAT; successful and partial (<330 degrees) MAT; or cases converted to traditional trabeculotomy when the Schlemm's canal could not be catheterized >180 degrees. Read More

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http://dx.doi.org/10.1097/IJG.0000000000001116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6309260PMC
January 2019
14 Reads
2.430 Impact Factor

Use of ab interno Kahook Dual Blade trabeculectomy for treatment of primary congenital glaucoma.

Eur J Ophthalmol 2018 Oct 14:1120672118805873. Epub 2018 Oct 14.

2 Department of Ophthalmology, Naval Medical Center, San Diego, CA, USA.

Introduction: Primary congenital glaucoma is a rare ocular disorder that is responsible for 0.01%-0.04% of total blindness worldwide. Read More

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http://journals.sagepub.com/doi/10.1177/1120672118805873
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http://dx.doi.org/10.1177/1120672118805873DOI Listing
October 2018
9 Reads

Factors associated with early and late failure after goniotomy for primary pediatric glaucoma.

Eur J Ophthalmol 2018 Oct 10:1120672118805872. Epub 2018 Oct 10.

Faculty of Medicine, Cairo University, Cairo, Egypt.

Purpose: To analyze the risk factors associated with early and late failure after goniotomy for primary pediatric glaucoma.

Methods: A retrospective study was done on infants who underwent goniotomy as the initial surgical procedure for primary pediatric glaucoma, and had a follow-up period ⩾48 months after surgery. Early and late failures were defined as intraocular pressure ⩾18 mmHg or signs of glaucoma progression before and after the end of first year, respectively. Read More

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http://dx.doi.org/10.1177/1120672118805872DOI Listing
October 2018
1 Read

Mutational analysis of the CYP1B1 gene in Pakistani primary congenital glaucoma patients: Identification of four known and a novel causative variant at the 3' splice acceptor site of intron 2.

Congenit Anom (Kyoto) 2018 Sep 30. Epub 2018 Sep 30.

Department of Animal Sciences, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan.

Primary congenital glaucoma (PCG) causes blindness in early age. It has an autosomal recessive pattern of inheritance, hence is more prevalent in populations with frequent consanguineous marriages that occur in the Pakistani population. Mutations in the CYP1B1 gene are commonly associated with PCG. Read More

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http://dx.doi.org/10.1111/cga.12312DOI Listing
September 2018
2 Reads

Corneal Biomechanical Properties and Thickness in Primary Congenital Glaucoma and Normal Eyes: A Comparative Study.

Med Hypothesis Discov Innov Ophthalmol 2018 ;7(2):68-72

Poostchi Ophthalmology Research Center, Department of Ophthalmology, Shiraz University of Medical Sciences, Shiraz, Iran.

The correct estimation of Intraocular Pressure (IOP) is the most important factor in the management of various types of glaucoma. Primary congenital glaucoma is a type of glaucoma that can cause blindness in the absence of control of the IOP. In this retrospective observational study, 95 eyes, including 48 healthy eyes and 47 eyes with Primary Congenital Glaucomatous (PCG) were studied. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6146241PMC
January 2018
20 Reads

Phenotype-genotype correlations and emerging pathways in ocular anterior segment dysgenesis.

Hum Genet 2018 Sep 21. Epub 2018 Sep 21.

Eye Genetics Research Unit, The Children's Hospital at Westmead, Save Sight Institute, Children's Medical Research Institute, The University of Sydney, Sydney, NSW, 2145, Australia.

Disorders of the anterior segment of the eye encompass a variety of clinical presentations including aniridia, Axenfeld and Rieger anomalies, primary congenital glaucoma, Peters anomaly, as well as syndromal associations. These conditions have a significant impact on vision due to disruption of the visual axis, and also secondary glaucoma which occurs in over 50% of patients. Ocular anterior segment disorders occur due to a complex interplay of developmental, embryological and genetic factors, and often have phenotypic overlaps and genetic heterogeneity. Read More

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http://dx.doi.org/10.1007/s00439-018-1935-7DOI Listing
September 2018
1 Read

Corneal hysteresis and glaucoma.

Int Ophthalmol 2018 Sep 5. Epub 2018 Sep 5.

Department of Ophthalmology, Yichang Central People's Hospital, The First College of Clinical Medical Science, China Three Gorges University, Yichang, 443003, People's Republic of China.

Purpose: To review and summarize the characteristics of corneal hysteresis (CH) and its relationship with glaucoma.

Methods: A PubMed search was carried out using the terms "corneal hysteresis", "glaucoma", and "biomechanics". Up to March 2018, all studies published in English are included in this review. Read More

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http://dx.doi.org/10.1007/s10792-018-1011-2DOI Listing
September 2018
2 Reads

Decompression retinopathy following nonpenetrating deep sclerectomy for primary congenital glaucoma.

BMC Ophthalmol 2018 Sep 5;18(1):240. Epub 2018 Sep 5.

Centre Hospitalier Universitaire de l'Hôpital Nord, chemin des Bourrely, 13015, Marseille, France.

Background: To describe a unique case of decompression retinopathy manifesting as pre-macular subhyaloid hemorrhage that occurs in a nine-day old child after undergoing a non-penetrating deep sclerectomy for primary congenital glaucoma.

Case Presentation: We report a single case of a 9-day-old boy who was referred to our department of ophthalmology for bilateral buphtalmia and corneal edema. He presented marked elevation of the intraocular pressure in both eyes (22 mmHg and 26 mmHg, in the right eye and left eye respectively) associated with significant optic nerve cupping. Read More

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https://bmcophthalmol.biomedcentral.com/articles/10.1186/s12
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http://dx.doi.org/10.1186/s12886-018-0906-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6126034PMC
September 2018
18 Reads

Corneal Configurations and High-order Aberrations in Primary Congenital Glaucoma.

J Glaucoma 2018 Dec;27(12):1112-1118

State Key Laboratory of Ophthalmology, Zhongshan Opthalmic Center, Sun Yat-Sen University, Guangzhou, People's Republic of China.

Purpose: Corneal changes are prevalent in eyes with primary congenital glaucoma (PCG). This study aimed to describe corneal irregularity and high-order aberrations (HOAs) in PCG eyes.

Materials And Methods: The study consecutively enrolled 61 PCG eyes (of 39 participants with PCG) and 61 age-matched control eyes (of 61 healthy participants). Read More

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http://dx.doi.org/10.1097/IJG.0000000000001049DOI Listing
December 2018
3 Reads

Agreement profiles for rebound and applanation tonometry in normal and glaucomatous children.

Eur J Ophthalmol 2018 Sep 4:1120672118795060. Epub 2018 Sep 4.

Department of Ophthalmology, Faculty of Medicine, Cairo University, Cairo, Egypt.

Objectives: To investigate agreement between intraocular pressure measurements by the rebound tonometer and handheld Perkins applanation tonometer in children with and without primary congenital glaucoma and test agreement with intraocular pressure and age variations.

Materials And Methods: A prospective non-interventional comparative study done on 223 eyes of 115 children, 161 normal eyes, and 62 eyes with primary congenital glaucoma. Intraocular pressure measurements were obtained in the upright position by rebound tonometer first, followed by installation of topical anesthetic eye drops (benoxinate), then measured by Perkins applanation tonometer. Read More

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http://dx.doi.org/10.1177/1120672118795060DOI Listing
September 2018
15 Reads

Correlation Between Trabeculodysgenesis Assessed by Ultrasound Biomicroscopy and Surgical Outcomes in Primary Congenital Glaucoma.

Am J Ophthalmol 2018 Dec 22;196:57-64. Epub 2018 Aug 22.

Beijing Tongren Eye Center, Beijing Tongren Hospital, Beijing Institute of Ophthalmology, Capital Medical University, Beijing, China. Electronic address:

Purpose: To evaluate ultrasound biomicroscopy (UBM) characteristics of trabeculodysgenesis and explore its correlation with the outcomes of microcatheter-assisted trabeculotomy (MAT) in eyes with primary congenital glaucoma (PCG).

Design: A prospective, interventional case series.

Methods: Patients with newly diagnosed PCG were consecutively recruited, and subsequently MAT was tried as their first glaucoma surgery. Read More

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http://dx.doi.org/10.1016/j.ajo.2018.08.022DOI Listing
December 2018
8 Reads
3.871 Impact Factor

Risk factors for flat anterior chamber after glaucoma filtration surgery.

Int J Ophthalmol 2018 18;11(8):1322-1329. Epub 2018 Aug 18.

Department of Ophthalmology, the Third Affiliated Hospital, Chongqing Medical University, Chongqing 400016, China.

Aim: To investigate the incidence rate and risk factors for grade III flat anterior chamber (FAC) after glaucoma filtration surgery based on 5-year data.

Methods: Patients who underwent glaucoma filtration surgery in Daping hospital from January 2009 to December 2013 were enrolled in this retrospective study. The incidence of grade III FAC following glaucoma filtration surgery was determined. Read More

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http://dx.doi.org/10.18240/ijo.2018.08.12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6090123PMC
August 2018
9 Reads
0.500 Impact Factor

Analysis of sequence alterations in patients with primary open-angle glaucoma of Saudi origin.

Clin Ophthalmol 2018 10;12:1413-1416. Epub 2018 Aug 10.

Glaucoma Research Chair, Department of Ophthalmology, College of Medicine, King Saud University, Riyadh, Saudi Arabia,

Cytochrome P450 Family 1 Subfamily B Member 1 (; OMIM# 601771) gene encodes one of the cytochrome P450 family of enzymes. mutations have been associated primarily with primary congenital glaucoma (PCG). Similar studies were reported in juvenile open-angle glaucoma, Rieger's and Peters anomalies. Read More

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https://www.dovepress.com/analysis-of-cyp1b1-sequence-altera
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http://dx.doi.org/10.2147/OPTH.S169943DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6089601PMC
August 2018
10 Reads

Clinical variability of CYP1B1 gene variants in Pakistani primary congenital glaucoma families.

J Pak Med Assoc 2018 Aug;68(8):1205-1211

School of Biological Sciences, University of Punjab, Lahore.

Objective: To explore the spectrum of Cytochrome P450 1B1 gene variants and genotype-phenotype correlations in families affected with primary congenital glaucoma.

Methods: The cross-sectional study was performed at the Department of Biotechnology, Lahore College for Women University, Lahore, and the School of Biological Sciences, University of the Punjab, Lahore, Pakistan, from February 2015 to October 2016. Six consanguineous families having individuals affected with primary congenital glaucoma were recruited from different hospitals of the city. Read More

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August 2018
1 Read

New classification system for pediatric glaucoma: implications for clinical care and a research registry.

Curr Opin Ophthalmol 2018 Sep;29(5):385-394

Sidney Kimmel Medical College at Thomas Jefferson University.

Purpose Of Review: The Childhood Glaucoma Research Network (CGRN) has created a new classification system for childhood glaucoma that has become the first International Consensus Classification. The purpose of this review is to present this classification system and share its use to date.

Recent Findings: The diagnoses of the classification system include glaucoma and glaucoma suspect. Read More

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http://dx.doi.org/10.1097/ICU.0000000000000516DOI Listing
September 2018
45 Reads

Primary congenital glaucoma including next-generation sequencing-based approaches: clinical utility gene card.

Eur J Hum Genet 2018 11 8;26(11):1713-1718. Epub 2018 Aug 8.

National Institute for Health Research (NIHR) Biomedical Research Centre at Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, EC1V 9EL, UK.

1. NAME OF THE DISEASE (SYNONYMS): Primary congenital glaucoma (PCG). Glaucoma, congenital (GLC). Read More

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http://dx.doi.org/10.1038/s41431-018-0227-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6189180PMC
November 2018
2 Reads

Outcomes of Silicone Ahmed Glaucoma Valve Implantation in Refractory Pediatric Glaucoma.

J Glaucoma 2018 Sep;27(9):769-775

VST Glaucoma Center.

Purpose: The purpose of this study was to report the outcomes of Silicone Ahmed Glaucoma Valve (AGV) implantation in the management of refractory pediatric glaucoma.

Methods: Between 2007 and 2015, 76 eyes of 64 children aged 16 years or younger underwent AGV implantation. We included 65 eyes of 53 children with follow up ≥6 months; 24 eyes had primary congenital glaucoma (PCG) and 41 eyes had secondary pediatric glaucoma (SPG). Read More

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http://Insights.ovid.com/crossref?an=00061198-201809000-0000
Publisher Site
http://dx.doi.org/10.1097/IJG.0000000000001032DOI Listing
September 2018
24 Reads