1,148 results match your criteria Glaucoma Primary Congenital


Spontaneously Arrested Bilateral Primary Congenital Glaucoma: A Case Report From Ethiopia.

Ethiop J Health Sci 2022 Mar;32(2):463-466

Department of Ophthalmology, School of Medicine, College of Health Sciences, Addis Ababa University, Ethiopia.

Background: Primary congenital glaucoma is potentially blinding condition characterized by elevated intraocular pressure and optic disc cupping. It is typically bilateral and usually manifest in the first year of life. Spontaneously arrested primary congenital glaucoma can occur, but it is very rare. Read More

View Article and Full-Text PDF

Animal Model Contributions to Primary Congenital Glaucoma.

J Ophthalmol 2022 26;2022:6955461. Epub 2022 May 26.

Sichuan Provincial Key Laboratory for Disease Gene Study, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China.

Primary congenital glaucoma (PCG) is an ocular disease characterized by congenital anterior segmental maldevelopment with progressive optic nerve degeneration. Certain genes, such as cytochrome P450 family 1 subfamily B member 1 and latent TGF--binding protein 2, are involved in the pathogenesis of PCG, but the exact pathogenic mechanism has not yet been fully elucidated. There is an urgent need to determine the etiology and pathophysiology of PCG and develop new therapeutic methods to stop disease progression. Read More

View Article and Full-Text PDF

Consanguinity and severity of primary congenital glaucoma.

J AAPOS 2022 May 10. Epub 2022 May 10.

Dr Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi.

Purpose: To evaluate the severity of primary congenital glaucoma (PCG) among children born of consanguineous marriage.

Methods: In this case-control study, the medical records of unrelated consanguineous patients and unrelated nonconsanguineous (control) PCG patients seen at a single tertiary eye care facility were retrospectively reviewed. Those with a minimum of 5 years' follow-up were included. Read More

View Article and Full-Text PDF

Ologen augmentation of Ahmed valves in pediatric glaucomas.

J AAPOS 2022 May 10. Epub 2022 May 10.

Division of Ophthalmology, Ann & Robert H. Lurie Children's Hospital of Chicago; Department of Ophthalmology, Northwestern University Feinberg School of Medicine. Electronic address:

Background: We previously showed that Ologen increased success and survival rates of Ahmed glaucoma devices in a small number of children. The current study analyzed the same surgical technique in an expanded cohort.

Methods: Retrospective interventional case series of children who underwent Ologen augmentation of Ahmed glaucoma device (OAGD) from 2018 to 2021 with ≥6 months' postoperative follow-up. Read More

View Article and Full-Text PDF

Ocular aberrations in eyes with Primary Congenital Glaucoma.

Curr Eye Res 2022 May 3:1-26. Epub 2022 May 3.

Dr Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India 110029.

Purpose: To highlight the magnitude of ocular higher order aberrations (HOA) and lower order aberrations (LOA), including component contributions from corneal and internal planes in Primary Congenital Glaucoma (PCG) patients.

Methods: Consecutive treated PCG patients co-operative for ocular examination and aberrometry, were enrolled over two years for this cross-sectional, comparative, single centre, unmasked study. Best corrected visual acuity, refraction, IOP, wavefront aberrometry and topography (iTrace) were performed and results were compared with unaffected fellow eyes of unilateral glaucoma patients as well as age and sex matched controls with no ocular anomalies other than treatable refractive error. Read More

View Article and Full-Text PDF

Clinical Analysis of Pediatric Glaucoma in Central China.

Front Med (Lausanne) 2022 1;9:874369. Epub 2022 Apr 1.

Henan Eye Institute, Henan Eye Hospital, Henan Provincial People's Hospital, Zhengzhou University People's Hospital, Zhengzhou, China.

Purpose: We aimed to describe the characteristics, epidemiology, management, and outcomes of glaucoma in pediatric patients in central China.

Methods: This study retrospectively analyzed inpatients with pediatric glaucoma at Henan Provincial People's Hospital, Henan Eye Institute, and Henan Eye Hospital between 2017 and 2020.

Results: Overall, 239 cases (276 eyes) of pediatric glaucoma in patients, comprising 87 girls (36. Read More

View Article and Full-Text PDF

Viscocanalostomy combined with trabeculotomy for management of refractory primary congenital glaucoma.

J AAPOS 2022 Apr 14. Epub 2022 Apr 14.

Farabi Eye Hospital, Tehran, Iran.

Purpose: To investigate the outcome of viscocanalostomy combined with trabeculotomy (VCO+tbo) in primary congenital glaucoma (PCG) with history of failed trabeculotomy.

Methods: In this prospective study, VCO+tbo was performed in 75 eyes of 46 patients with PCG who had not responded adequately to one angle surgery. Success was defined as intraocular pressure (IOP) of 6-21 mm Hg and at least 20% IOP drop at the last postoperative visit with (qualified) or without (complete) glaucoma medications. Read More

View Article and Full-Text PDF

Primary intraocular lens implantation in infants with unilateral congenital cataract operated before 12 weeks of age.

Acta Ophthalmol 2022 Apr 11. Epub 2022 Apr 11.

Department of Ophthalmology, Oslo University Hospital, Oslo, Norway.

Purpose: The aim of this study was to report visual outcome and safety after cataract surgery with primary intraocular lens implantation before 12 weeks of age.

Methods: Infants with visually significant unilateral congenital cataract having primary IOL implantation in the capsular bag before 12 weeks of age in 2007-2016 were enrolled for a prospective study examination in 2017. The medical records were also reviewed. Read More

View Article and Full-Text PDF

Geographical Variability in Mutations in Primary Congenital Glaucoma.

J Clin Med 2022 Apr 6;11(7). Epub 2022 Apr 6.

Department of Biomedical Sciences, West Virginia School of Osteopathic Medicine, Lewisburg, WV 24901, USA.

Primary congenital glaucoma (PCG) is a rare type of glaucoma that is inherited in an autosomal recessive manner. PCG can lead to blindness if not detected early in children aged 3 or younger. PCG varies in presentation among various populations, where disease presentation and disease severity vary by mutation. Read More

View Article and Full-Text PDF

Etiology and outcomes of childhood glaucoma at a tertiary referral center.

J AAPOS 2022 Apr 8. Epub 2022 Apr 8.

Department of Ophthalmology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts.

Purpose: To describe the etiology, clinical features, and outcomes for a large contemporary cohort of children presenting with glaucoma at a tertiary referral center.

Methods: The medical records of patients presenting to Boston Children's Hospital from January 2014 to July 2019 with a diagnosis of childhood glaucoma were retrospectively reviewed. Data regarding etiology, treatment, and visual and anatomic outcomes were collected; visual acuity outcomes were analyzed by laterality and diagnosis categories, using the Childhood Glaucoma Research Network (CGRN) classifications. Read More

View Article and Full-Text PDF

Microcatheter-assisted circumferential trabeculotomy in primary congenital glaucoma.

Saudi J Ophthalmol 2021 Apr-Jun;35(2):117-121. Epub 2022 Feb 18.

Department of Ophthalmology, Faculty of medicine, Minia University, 61519, El-Minia, Egypt.

Purpose: To study circumferential trabeculotomy for congenital glaucoma using Glaucolight illuminated microcatheter.

Methods: This was a prospective, uncontrolled, consecutive interventional study of 25 eyes of 25 patients with primary congenital glaucoma (PCG) underwent circumferential trabeculotomy done with an illuminated microcatheter through a period of 18-24 months in ophthalmology department, faculty of medicine, Minia University, Egypt. Patients' data of 12 months' follow-up were recorded. Read More

View Article and Full-Text PDF
February 2022

Bilateral anterior segment dysgenesis in a 7-week-old domestic shorthaired cat.

Authors:
Erin Douglas

Can Vet J 2022 04;63(4):435-438

Department of Companion Animals, Atlantic Veterinary College, University of Prince Edward Island, 550 University Avenue, Charlottetown, Prince Edward Island C1A 4P3.

A 7-week-old, intact, female domestic shorthaired cat was presented to the Atlantic Veterinary College (AVC) Ophthalmology service for a 1-week history of buphthalmia in the left eye and bilateral elevated intraocular pressures. Ocular examination revealed bilateral non-visual glaucomatous eyes. Bilateral enucleations were performed without complications and histopathology revealed anterior segment dysgenesis of varying degrees in both eyes. Read More

View Article and Full-Text PDF

Outcomes of Surgical Interventions in Primary Congenital Glaucoma Patients.

J Glaucoma 2022 04;31(4):274-279

Department of Ophthalmology, Faculty of Medicine, Chulalongkorn University and King Chulalongkorn Memorial Hospital, Thai Red Cross Society.

Purpose: The aim was to report long-term surgical success of primary congenital glaucoma (PCG) patients in Thailand.

Materials And Methods: PCG patients who underwent one of the following primary operations: trabeculotomy, goniotomy, trabeculectomy, combined trabeculotrabeculectomy (CTT) and diode transscleral cyclophotocoagulation (TSCPC) between January 1992 and January 2018 were reviewed. Surgical success was defined as intraocular pressure (IOP) between 5 and 21 mm Hg with or without antiglaucoma medications. Read More

View Article and Full-Text PDF

Factors affecting the surgical success of trabeculectomy performed as the first surgery in primary pediatric glaucoma.

Int Ophthalmol 2022 Mar 30. Epub 2022 Mar 30.

Department of Ophthalmology, Başkent University Faculty of Medicine, Ankara, Turkey.

Purpose: To present the outcomes and factors affecting the success of trabeculectomy performed as the first surgery in primary pediatric glaucoma.

Methods: Pediatric patients with primary glaucoma who underwent trabeculectomy as the first surgery were retrospectively reviewed. Age, gender, preoperative intraocular pressure (IOP), operation age, axial length, corneal diameter, anterior segment findings, antimetabolite used, complications, and 1-month, 3-months, 1-year, and most recent postoperative findings were recorded. Read More

View Article and Full-Text PDF

Effect of surgical timing in 23-g pars plana vitrectomy for primary repair of macula-off rhegmatogenous retinal detachment, a retrospective study.

BMC Ophthalmol 2022 Mar 25;22(1):136. Epub 2022 Mar 25.

Department of Ophthalmology, University of Virginia, Charlottesville, VA, USA.

Background: Rhegmatogenous retinal detachment (RRD) is a common, potentially blinding ocular pathology that is considered a surgical emergency. Macular involvement has been identified as a major negative prognostic indicator for visual recovery after RRD correction. It is not currently clear whether early intervention improves visual outcomes, and in practice, there are potential disadvantages to performing early surgery for fovea-involving RRD. Read More

View Article and Full-Text PDF

Surgical outcomes of primary intraocular lens implantation for the treatment of aphakia in pediatric cataracts in the Brazilian public health system.

Arq Bras Oftalmol 2022 Mar 21. Epub 2022 Mar 21.

Faculdade de Medicina de Botucatu, Universidade Estadual Paulista "Júlio de Mesquita Filho", Botucatu, SP, Brazil.

Purpose: To evaluate primary intraocular lens implantation in the treatment of children's aphakia in the Brazilian public health system and compare the outcomes among different age groups.

Methods: Children aged 0-12 years old with unilateral or bilateral congenital/developmental cataracts and underwent primary intraocular lens implantation were included.

Results: A total of 108 eyes from 68 children were evaluated, and the children were divided into four age groups (<7 months [mo]; 7 mo-2 years old [y/o]; 2-5 y/o, and >5 y/o) were evaluated. Read More

View Article and Full-Text PDF

Management of a recurrent encapsulated bleb with a cost-effective non-valved glaucoma drainage device.

BMJ Case Rep 2022 Mar 14;15(3). Epub 2022 Mar 14.

Glaucoma Services, University of Miami School of Medicine, Bascom Palmer Eye Institute, Miami, Florida, USA.

Despite the advancements in the surgical management of glaucoma, childhood glaucoma remains a challenging surgical disease worldwide. An early adolescent boy with primary congenital glaucoma, status after glaucoma drainage device (GDD) implantation, on maximum medical therapy, was presented with a swelling in the superotemporal orbital region. The patient had undergone an uneventful GDD implantation 2 years prior to presentation. Read More

View Article and Full-Text PDF

Glaucoma and risk factors three years after congenital cataract surgery.

BMC Ophthalmol 2022 Mar 12;22(1):118. Epub 2022 Mar 12.

Eye Hospital and School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou, Zhejiang, China.

Background: This study aimed to identify the incidence of and risk factors for postoperative glaucoma-related adverse events at various time points after congenital cataract surgery.

Methods: This retrospective cohort study enrolled 259 eyes from 174 patients (surgical age ≤ 7 years) who underwent congenital cataract surgery. All surgical procedures were conducted at the Eye Hospital of Wenzhou Medical University between May 2011 and March 2019. Read More

View Article and Full-Text PDF

Long-Term Visual Outcomes of Primary Congenital Glaucoma in China.

Ophthalmic Res 2022 10;65(3):342-350. Epub 2022 Mar 10.

Zhongshan Ophthalmic Center, State Key Laboratory of Ophthalmology, Sun Yat-Sen University, Guangzhou, China.

Introduction: The aim of this study was to investigate the long-term visual outcomes and factors associated with vision loss in Chinese patients with primary congenital glaucoma (PCG) after successful intraocular pressure (IOP) control (IOP ≤21 mm Hg).

Methods: PCG patients with IOP control who were examined in the glaucoma clinic at Zhongshan Ophthalmic Center from 2019 to 2020 were enrolled. The final visual outcome was evaluated by the best corrected visual acuity (VA). Read More

View Article and Full-Text PDF

Combined nasal goniotomy - temporal trabeculotomy (NGTT) for circumferential angle surgery in primary congenital glaucoma.

Eur J Ophthalmol 2022 Mar 7:11206721221085395. Epub 2022 Mar 7.

Kasr Al-Aini Hospital - 63526Cairo University, Cairo, Egypt.

Purpose: To assess the safety and efficacy of combining nasal goniotomy with temporal trabeculotomy in the management of primary congenital glaucoma.

Design: Case series.

Methods: Fifteen eyes of eleven children (3-12 months old at presentation) were enrolled in this study after the establishment of PCG diagnosis based on the criteria placed by the World Glaucoma Association. Read More

View Article and Full-Text PDF

Letter to the Editor: Trabeculotomy Versus Combined Trabeculotomy-Trabeculectomy for Management of Primary Congenital Glaucoma.

J Glaucoma 2022 May 3;31(5):e16-e17. Epub 2022 Mar 3.

Advanced Eye Centre, Postgraduate Institute of Medical Education and Research, Chandigarh, Chandigarh, India.

View Article and Full-Text PDF

Primary Congenital Glaucoma among the Children Under 3 Years of Age in the Outpatient Department in a Tertiary Care Hospital: A Descriptive Cross-sectional Study.

JNMA J Nepal Med Assoc 2021 Sep 11;59(241):867-870. Epub 2021 Sep 11.

Department of Medical Education, Biratnagar Eye Hospital, Biratnagar, Nepal.

Introduction: Primary congenital glaucoma is a rare vision-threatening condition of children. Primary congenital glaucoma though a rare disease it is the most common cause of childhood glaucoma with potency to cause blindness. This study was undertaken to find the prevalence of the children with primary congenital glaucoma under 3 years of age in a tertiary care hospital. Read More

View Article and Full-Text PDF
September 2021

Gonioscopy-assisted transluminal trabeculotomy in primary congenital glaucoma.

Am J Ophthalmol Case Rep 2022 Mar 29;25:101366. Epub 2022 Jan 29.

Shiley Eye Institute, Hamilton Glaucoma Center, Viterbi Family Department of Ophthalmology, University of California San Diego, La Jolla, CA, USA.

Purpose: To report a case of gonioscopy-assisted transluminal trabeculotomy (GATT) in a patient with primary congenital glaucoma.

Observations: A three-year-old boy who presented with buphthalmos and elevated intraocular pressure. Despite the presence of iris and iris processes extending to Schwalbe's line, GATT was performed successfully. Read More

View Article and Full-Text PDF

Childhood glaucoma registry in Germany: initial database, clinical care and research (pilot study).

BMC Res Notes 2022 Feb 10;15(1):32. Epub 2022 Feb 10.

Department of Ophthalmology, University Medical Center of the Johannes Gutenberg, University Mainz, Mainz, Germany.

Objective: The aim of this prospective pilot study is to establish an initial database to register patients diagnosed with different types of childhood glaucoma and the set-up of a national registry for childhood glaucoma (ReCG) in Germany. 28 children with different types of diagnosed childhood glaucoma, who were admitted and treated at the Childhood Glaucoma Center of the University Medical Center Mainz, Germany were included. Main outcome measures were the type of childhood glaucoma, mean intraocular pressure (IOP) and genetic data of the patients. Read More

View Article and Full-Text PDF
February 2022

Profile of primary childhood glaucoma at a child eye health tertiary facility in Malawi.

BMC Ophthalmol 2022 Jan 31;22(1):45. Epub 2022 Jan 31.

Kamuzu University of Health Sciences, Blantyre, Malawi.

Background: To describe the clinical characteristics and treatment of primary childhood glaucoma at Queen Elizabeth Central Hospital in Blantyre, Malawi.

Methods: A retrospective case notes review was undertaken of all medical records of patients aged less than 16 years with a diagnosis of primary glaucoma according to the Childhood Glaucoma Research Network Classification (CGRN) who presented from January 2016 to December 2018. The parameters extracted from the case files included age at presentation, sex, type of glaucoma, presenting complaints, laterality of ocular involvement, examination findings and the treatment modality instituted. Read More

View Article and Full-Text PDF
January 2022

Exome-based mutation screening in South African children with primary congenital glaucoma.

Eye (Lond) 2022 Jan 29. Epub 2022 Jan 29.

Division of Ophthalmology, Department of Neurosciences, School of Clinical Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.

Objectives: To identify pathogenic variants in a cohort of 23 black South African children with sporadic primary congenital glaucoma (PCG) using an exome-based approach.

Methods: Children with PCG were recruited from two Paediatric Ophthalmology Clinics in Johannesburg, South Africa. Whole exome sequencing was performed on genomic DNA. Read More

View Article and Full-Text PDF
January 2022

Neonatal-Onset Congenital Ectropion Uveae May Be Caused by a Distinct CYP1B1 Pathologic Variant.

Am J Ophthalmol 2022 Jul 24;239:54-65. Epub 2022 Jan 24.

From the Advanced Eye Center and Advanced Pediatric Center, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Purpose: To report underlying genetic variants of recently described distinct phenotype of newborn glaucoma: neonatal-onset congenital ectropion uveae (NO-CEU).

Design: Prospective cohort study.

Methods: Setting: tertiary care teaching institute. Read More

View Article and Full-Text PDF

Microcatheter-Assisted Circumferential Trabeculotomy in Primary Congenital Glaucoma: Long-Term Clinical Outcomes.

J Clin Med 2022 Jan 14;11(2). Epub 2022 Jan 14.

Ophthalmology Unit, Azienda USL-IRCCS di Reggio Emilia, 42122 Reggio Emilia, Italy.

Purpose: The purpose of this study was to report the long-term efficacy and clinical outcomes of microcatheter-assisted circumferential trabeculotomy (MCT) in children with primary congenital glaucoma (PCG).

Methods: This is a single-center retrospective study including consecutive children with PCG who underwent MCT with > two years follow up. The primary outcome was surgical success, defined as intraocular pressure (IOP) ≤ 21 mmHg with (qualified) or without (complete) medications, measured at six months, one year, and then annually. Read More

View Article and Full-Text PDF
January 2022