66,619 results match your criteria Glaucoma Pigmentary


Gelatinized core liposomes: A new Trojan horse for the development of a novel timolol maleate glaucoma medication.

Int J Pharm 2018 Dec 12. Epub 2018 Dec 12.

Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy , Ain Shams University, African Union Street Authority Street, Abbassia, 11566 Cairo, Egypt.

Glaucoma treatment with ocular medications requires overcoming the corneal barrier to drug penetration. Liposomes have a great corneal penetration ability and affinity while suffering from poor stability and low entrapment of hydrophilic drugs accompanied by rapid drug release. This work aims to develop a new, effective and stable glaucoma medication with sustained drug release properties; Timolol maleate gelatinized core liposomes. Read More

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December 2018

Choroidal microvascular dropout in primary angle closure glaucoma.

Am J Ophthalmol 2018 Dec 12. Epub 2018 Dec 12.

University Eye Clinic Maastricht, University Medical Center, Maastricht, the Netherlands.

Purpose: To determine the prevalence and factors associated with the presence of choroidal microvascular dropout (CMvD) in primary angle-closure glaucoma (PACG) eyes compared to primary open-angle glaucoma (POAG) eyes.

Design: Cross-sectional study METHODS: Thirty-six POAG eyes (36 patients) and 28 PACG eyes (28 patients) underwent optical coherence tomography angiography (OCTA). Presence of CMvD was evaluated on choroidal OCTA slabs. Read More

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December 2018

Case series of hypotony maculopathy after CyPass insertion treated with intra-luminal suture occlusion.

Clin Exp Ophthalmol 2018 Dec 15. Epub 2018 Dec 15.

Glaucoma Service, Moorfields Eye Hospital, London EC1V 2PD, United Kingdom. UCL Institute of Ophthalmology, London, United Kingdom.

The CyPass Micro-Stent (Alcon, Fort Worth, USA) is a minimally invasive glaucoma surgical (MIGS) device, implanted into the supra-choroidal space. The CyPass was FDA approved in July 2016 and CE marked in Europe. It was withdrawn voluntarily by the manufacturer in August 2018. Read More

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December 2018

[Glaucoma and nanophthalmos].

Ophthalmologe 2018 Dec 14. Epub 2018 Dec 14.

Zentrum für Augenheilkunde, Uniklinik Köln, Joseph-Stelzmann Str. 9, 50931, Köln, Deutschland.

The term nanophthalmos refers to a clinically small eye that appears morphologically normal. A nanophthalmos is characterized by hyperopia but can also be associated with various secondary pathologies, such as angle-closure glaucoma. In particular, the perioperative risks associated with a nanophthalmic eye necessitate examination of the anatomical characteristics, which can result from the disproportional size of intraocular tissues despite structural normality. Read More

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December 2018

1-year outcomes of the Xen45 glaucoma implant.

Eye (Lond) 2018 Dec 14. Epub 2018 Dec 14.

Ophthalmology Department, Yeovil Hospital, Yeovil, UK.

Objectives: To describe the 12-month outcomes of the Xen45 glaucoma stent.

Methods: Non-comparative retrospective study of all cases who underwent Xen glaucoma surgery in April 2017 or earlier and completed 12 months of follow-up. The primary outcome measures were intraocular pressure (IOP) reduction and number of glaucoma medications at 12 months postoperatively. Read More

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December 2018

The Relationship Between Peripapillary Vascular Density and Visual Field Sensitivity in Primary Open-Angle and Angle-Closure Glaucoma.

Invest Ophthalmol Vis Sci 2018 Dec;59(15):5862-5867

Department of Clinical Epidemiology and Biostatistics, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

Purpose: To investigate whether the relationship between circumpapillary vascular density (cpVD) and visual field (VF) mean sensitivity (MS) differs between primary open-angle (POAG) and angle-closure glaucoma (PACG).

Methods: The cpVD and retinal nerve fiber layer thickness (RNFLT) were obtained using optical coherence tomography angiography (OCTA, AngioVue/RTVue-XR) in 146 eyes from 146 subjects (age- and VF mean deviation-matched 86 POAG and 60 PACG). Global and regional relationships (superotemporal [ST], superonasal [SN], nasoupper [NU], nasolower [NL], inferonasal [IN], inferotemoporal [IT], temporolower [TL], and temporoupper [TU] sectors) were estimated between cpVD and VF MS using multiple linear regression models controlling for the confounding variables in two disease categories. Read More

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December 2018

Δ9-Tetrahydrocannabinol and Cannabidiol Differentially Regulate Intraocular Pressure.

Invest Ophthalmol Vis Sci 2018 Dec;59(15):5904-5911

The Gill Center for Biomolecular Science and the Department of Psychological and Brain Sciences, Indiana University, Bloomington, Indiana, United States.

Purpose: It has been known for nearly 50 years that cannabis and the psychoactive constituent Δ9-tetrahydrocannabinol (THC) reduce intraocular pressure (IOP). Elevated IOP remains the chief hallmark and therapeutic target for glaucoma, a major cause of blindness. THC likely acts via one of the known cannabinoid-related receptors (CB1, CB2, GPR18, GPR119, GPR55) but this has never been determined explicitly. Read More

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December 2018
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Speg. Implicated in Keratomycosis.

Pol J Microbiol 2018 ;67(4):407-416

Department of Plant Pathology and Mycology, University of Life Sciences in Lublin , Lublin , Poland.

The aim of the study was mycological examination of ulcerated corneal tissues from an ophthalmic patient. Tissue fragments were analyzed on potato-glucose agar (PDA) and maltose (MA) (Difco) media using standard laboratory techniques. Cultures were identified using classical and molecular methods. Read More

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January 2018

Thickness of the Macula, Retinal Nerve Fiber Layer, and Ganglion Cell-inner Plexiform Layer in the Macular Hole: The Repeatability Study of Spectral-domain Optical Coherence Tomography.

Korean J Ophthalmol 2018 Dec;32(6):506-516

Department of Ophthalmology, Chungnam National University College of Medicine, Daejeon, Korea.

Purpose: We measured the thicknesses of the ganglion cell and inner plexiform layer (GCIPL), the macula, and the retinal nerve fiber layer (RNFL) using spectral-domain optical coherence tomography in patients with idiopathic macula holes to analyze the repeatability of these measurements and compare them with those of the fellow eye.

Methods: We evaluated 85 patients who visited our retinal clinic. The patients were divided into two groups according to their macular hole size: group A had a size of <400 μm, while group B had a size of ≥400 μm. Read More

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December 2018
3 Reads

Relationship between Progressive Changes in Lamina Cribrosa Depth and Deterioration of Visual Field Loss in Glaucomatous Eyes.

Korean J Ophthalmol 2018 Dec;32(6):470-477

Department of Ophthalmology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

Purpose: To investigate the relationship between the progression of visual field (VF) loss and changes in lamina cribrosa depth (LCD) as determined by spectral-domain optical coherence tomography (SD-OCT) enhanced depth imaging in patients with primary open angle glaucoma (POAG).

Methods: Data from 60 POAG patients (mean follow-up, 3.5 ± 0. Read More

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December 2018

Review of rodent hypertensive glaucoma models.

Acta Ophthalmol 2018 Dec 13. Epub 2018 Dec 13.

Department of Ophthalmology & Visual Sciences, Chinese University of Hong Kong, Hong Kong, Hong Kong.

Glaucoma is a neurodegenerative disease characterized by the progressive loss of retinal ganglion cells (RGCs). Elevated intraocular pressure (IOP) is a primary risk factor for the development and progression of glaucoma. Rodent models of glaucoma have greatly improved our understanding of the pathophysiology of glaucoma and served as a useful tool to investigate neuroprotective agents. Read More

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December 2018

Changes in Australian practice patterns for glaucoma management.

Clin Exp Ophthalmol 2018 Dec 13. Epub 2018 Dec 13.

South Australian Institute of Ophthalmology, The University of Adelaide, South Australia, Australia.

Importance: The demand for glaucoma care is projected to increase significantly with the ageing population.

Background: To characterise trends in Australian practice patterns for glaucoma management over the 15-year period between 2003 and 2017.

Design: Retrospective audit. Read More

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December 2018
1 Read

Sharpening the focus on ophthalmology teaching: has anything changed?

Authors:
Catherine Green

Clin Exp Ophthalmol 2018 Dec;46(9):981-983

Royal Australian and New Zealand College of Ophthalmologists, Sydney, New South Wales, Australia.

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December 2018
1 Read

Curcumin: A new candidate for retinal disease therapy?

J Cell Biochem 2018 Dec 11. Epub 2018 Dec 11.

Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, Iran.

The retina is the neural portion and light-sensitive layer of the eye, which has been observed in most of the vertebrates. The retina is composed of light-sensitive cells that absorb light and convert it into neural signals. These signals are sent to the brain for visual recognition. Read More

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December 2018
1 Read

Glaucoma - Next Generation Therapeutics: Impossible to Possible.

Pharm Res 2018 Dec 13;36(2):25. Epub 2018 Dec 13.

Ophthalmology Research, Novartis Institutes for Biomedical Research, 22 Windsor Street, Cambridge, Massachusetts, 02139, USA.

The future of next generation therapeutics for glaucoma is strong. The recent approval of two novel intraocular pressure (IOP)-lowering drugs with distinct mechanisms of action is the first in over 20 years. However, these are still being administered as topical drops. Read More

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December 2018
1 Read

[Selective laser trabeculoplasty in African blacks].

J Fr Ophtalmol 2018 Dec 10. Epub 2018 Dec 10.

Service d'ophtalmologie, Chu Treichville, Abidjan, Côte d'Ivoire.

Introduction: The treatment of primary open angle glaucoma (POAG) is preferably medical. However, when medical therapy fails, alternative or complementary treatments may be considered. In this regard, selective laser trabeculoplasty is a widely popular procedural treatment whose accepted benefits have been very little studied in African blacks. Read More

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December 2018

Post-phacoemulsification iris changes in eyes with glaucoma or glaucoma suspect status.

PLoS One 2018 13;13(12):e0208776. Epub 2018 Dec 13.

University of California at San Francisco, Department of Ophthalmology, San Francisco, California, United States of America.

Purpose: This prospective study used anterior segment optical coherence tomography (AS-OCT) to determine how phacoemulsification (phaco) changes iris parameters in eyes with glaucoma or glaucoma suspect status.

Methods: Using Visante AS-OCT (Carl Zeiss Meditec AG), the following pre- and post-phaco parameters were measured: IT750 = iris thickness at 750 μm from the scleral spur; IT2000 = iris thickness 2000 μm from the scleral spur; ITCM = the maximum iris thickness at the middle one third of the iris; ICURV = iris curvature; IAREA = iris area; and pupil size = pupil diameter (mm). Only high-quality images with an identifiable scleral spur were included, and only the nasal quadrant was analyzed. Read More

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December 2018

Preliminary Steps to Address Glaucoma Medication Adherence: Beginning to Tackle the Elephant in the Room.

JAMA Ophthalmol 2018 Dec 13. Epub 2018 Dec 13.

Wills Eye Hospital, Thomas Jefferson University, Philadelphia, Pennsylvania.

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December 2018

Reduced Cerebrospinal Fluid Inflow to the Optic Nerve in Glaucoma.

Invest Ophthalmol Vis Sci 2018 Dec;59(15):5876-5884

Keenan Research Centre for Biomedical Science, Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, Ontario, Canada.

Purpose: To determine whether cerebrospinal fluid (CSF) entry into the optic nerve is altered in glaucoma.

Methods: Fluorescent 10-kDa dextran tracer was injected into the CSF of 2-month-old (n = 9) and 10-month-old DBA/2J glaucoma mice (n = 8) and age-matched controls (C57Bl/6; n = 8 each group). Intraocular pressure (IOP) was measured in all mice before tracer injection into CSF. Read More

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December 2018

Association of an Electronic Health Record-Linked Glaucoma Medical Reminder With Patient Satisfaction.

JAMA Ophthalmol 2018 Dec 13. Epub 2018 Dec 13.

Glaucoma Center of Excellence, Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland.

Importance: While dosing reminders for glaucoma medications have been shown to increase drug adherence, an outstanding limitation preventing broad adoption is difficulty linking reminders to medication in each patient's electronic health record (EHR).

Objective: To examine the feasibility of implementing an EHR-linked, automated reminder system for glaucoma medications and assess patient satisfaction with it.

Design, Setting, And Participants: In this prospective, cross-sectional study, patients receiving glaucoma medications were recruited from a university-based glaucoma clinic from April 2017 to January 2018. Read More

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December 2018

Transcriptional profiling analysis predicts potential biomarkers for glaucoma: HGF, AKR1B10 and AKR1C3.

Exp Ther Med 2018 Dec 17;16(6):5103-5111. Epub 2018 Oct 17.

Department of Ophthalmology, The People's Hospital of Shouguang, Weifang, Shandong 262700, P.R. China.

Glaucoma results in damage to the optic nerve and vision loss. The aim of this study was to screen more accurate biomarkers and targets for glaucoma. The datasets E-GEOD-7144 and E-MEXP-3427 were screened for differently expressed genes (DEGs) by significance analysis of microarrays. Read More

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December 2018

Activation of 5-HT1A receptors promotes retinal ganglion cell function by inhibiting the cAMP-PKA pathway to modulate presynaptic GABA release in chronic glaucoma.

J Neurosci 2018 Dec 12. Epub 2018 Dec 12.

Eye Institute, Eye & ENT Hospital, State Key Laboratory of Medical Neurobiology, Institutes of Brain Science and Collaborative Innovation Center for Brain Science, Shanghai Medical College, Fudan University, Shanghai 200032, China.

Serotonin receptor agonists are neuroprotective in central nervous system (CNS) injury models. However, the neuroprotective functional implications and synaptic mechanism of 8-OH-DPAT, a serotonin receptor (5-HT1A) agonist, in an adult male Wistar rat model of chronic glaucoma model remain unknown. We found that ocular hypertension decreased 5-HT1A receptor expression in rat retinas, as the number of retinal ganglion cells (RGCs) was significantly reduced in rats with induced ocular hypertension relative to that in control retinas, and 8-OH-DPAT enhanced the RGC viability. Read More

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December 2018

The Difference between Ganglion Cell Complex and Nerve Fiber Layer in the Same Altitudinal Halves of the Retina in Hyper-tension and Normal-tension Glaucomas.

Cesk Slov Oftalmol 2018 ;73(5-6):218-221

Nerve Fiber Layer (RNFL) measurements in the same altitudinal half of the eye in hyper-tension (HTG) and normal-tension glaucomas (NTG).

Materials And Methods: We examined both eyes in altogether 50 patients (100 eyes). The cohort was divided into two groups, in each of them; there were 25 patients with average age of 55. Read More

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January 2018

Use of ex-press® implant in glaucoma surgery - retrospective study.

Authors:
V Fialová M Váša

Cesk Slov Oftalmol 2018 ;74(1):9-14

Purpose: The objective of the study is to evaluate of primary open-angle glaucoma (POAG) with the use of EX-PRESS drainage implant. Evaluated was the decrease of intraocular pressure (IOP), visus stabilization, perimeter Humphrey - related finding (T 30-2), Heidelberg Retina Tomograph (HRT) and possibility of reducing the local drug therapy.

Patients And Methods: Retrospective data analysis was performed in 40 eyes with POAG in 28 subjects (14 female- and 14 male patients) average-aged 69. Read More

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January 2018

The Pulfrich Phenomenon: Practical Implications of the Assessment of Cases and Effectiveness of Treatment.

Neuroophthalmology 2018 Dec 25;42(6):349-355. Epub 2018 Apr 25.

Department of Neuro-ophthalmology, Moorfields Eye Hospital, London, United Kingdom.

The Pulfrich phenomenon, originally described in normal observers, is a treatable disorder of the perception of movement in depth in cases of unilateral or asymmetric optic neuropathy. Treatment is highly bespoke and factors influencing treatment response and failure remain unclear. We assessed 25 adults with suspected Pulfrich phenomenon due to a range of conditions in two tertiary referral centres. Read More

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December 2018

The Role of Endogenous Neuroprotective Mechanisms in the Prevention of Retinal Ganglion Cells Degeneration.

Front Neurosci 2018 15;12:834. Epub 2018 Nov 15.

Chair and Department of Physiology, School of Medicine in Katowice, Medical University of Silesia, Katowice, Poland.

Retinal neurons are not able to undergo spontaneous regeneration in response to damage. A variety of stressors, i.e. Read More

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November 2018

Intraocular Pressure After Corneal Refractive Surgery.

Med Arch 2018 Nov;72(5):341-343

Clinic Gjermane e Syrit, Prishtina, Republic of Kosovo.

Introduction: Laser in situ keratomileusis (LASIK), a refractive surgery procedure is being performed in a large number among people with refractive errors. In all the people undergoing the procedure, there is a potential risk to misdiagnose the glaucoma disease due to changes in central corneal thickness (CCT). In subjects who have undergone laser refractive interventions, intraocular tension may be lower and underestimated, and this can lead to later detection of glaucoma. Read More

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November 2018

Patient Reported Outcomes, Functional Assessment and Utility Values in Glaucoma.

J Glaucoma 2018 Dec 11. Epub 2018 Dec 11.

Johns Hopkins Wilmer Eye Institute, Maryland USA.

In clinical glaucoma research, the measurement of patient reported outcomes, functional assessment of disability, and health economic impact is critical. However, valid, time-efficient and comprehensive tools are not available and several current instruments lack in the appropriate precision for measuring the various dimensions of glaucoma-related quality of life (QoL), including functioning and mobility. Furthermore, statistical methods are inconsistently and sometimes incorrectly used in otherwise sound clinical studies. Read More

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December 2018
2 Reads

Effect of Mannitol on Intraocular Pressure in Vitrectomized and Non-vitrectomized Eyes: A Prospective Comparative Study.

J Glaucoma 2018 Dec 11. Epub 2018 Dec 11.

Glaucoma Services, Aravind Eye Hospital, Coimbatore, India.

Purpose: To compare the effect of mannitol in reducing intraocular pressure (IOP) in vitrectomized and non-vitrectomized eyes.

Methods: Prospective comparative case study. Eyes with IOP ≥40▒mm Hg were included. Read More

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December 2018

Re: Radke et al - The Translaminar Pressure Gradient - Papilledema After Trabeculectomy Treated With Optic Nerve Sheath Fenestration.

Authors:
David Fleischman

J Glaucoma 2018 Dec 11. Epub 2018 Dec 11.

Department of Ophthalmology, University of North Carolina at Chapel Hill.

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December 2018

Management of Tube Exposure Following Ahmed Glaucoma Valve Implantation by Allograft Corneoscleral Rim Patch.

J Glaucoma 2018 Dec 11. Epub 2018 Dec 11.

Glaucoma Services, Department of Ophthalmology, GSVM Medical College, Kanpur, UP (India).

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December 2018

Hypohidrotic Ectodermal Dysplasia: A Rare Disorder with Bilateral Infantile Glaucoma.

J Glaucoma 2018 Dec 11. Epub 2018 Dec 11.

Glaucoma and anterior segment, Dr. Shroff's charity eye hospital, Delhi.

Ectodermal dysplasia is a disorder that occurs due to abnormalities of ectodermal structures such as skin, teeth, hair, nails, and eccrine glands. Approximately 200 different conditions have been identified as ectodermal dysplasia, the most common being hypohidrotic ectodermal dysplasia (HED). It is characterized by hypotrichosis (sparse scalp or body hair), hypodontia (absent or malformed teeth) and hypohidrosis (reduced ability to sweat). Read More

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December 2018
2 Reads

imaging of structural, metabolic and functional brain changes in glaucoma.

Neural Regen Res 2019 Mar;14(3):446-449

NYU Langone Eye Center, Department of Ophthalmology, NYU School of Medicine, NYU Langone Health; Department of Radiology, NYU School of Medicine, NYU Langone Health; Center for Neural Science, Faculty of Arts and Science, New York University, New York, NY, USA.

Glaucoma, the world's leading cause of irreversible blindness, is a condition for which elevated intraocular pressure is currently the only modifiable risk factor. However, the disorder can continue to progress even at reduced intraocular pressure. This indicates additional key factors that contribute to the etiopathogenesis. Read More

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March 2019
2 Reads

Basics on the use of acid-sensing ion channels' inhibitors as therapeutics.

Neural Regen Res 2019 Mar;14(3):395-398

North Texas Eye Research Institute, Department of Pharmacology and Neuroscience, University of North Texas Health Science Center at Fort Worth, Fort Worth, TX, USA.

Since the discovery of acid-sensing ion channels in 1997, their importance in the health of neurons and other non-neuronal cells has gained significant importance. Acid-sensing ion channels play important roles in mediating pain sensation during diseases such as stroke, inflammation, arthritis, cancer, and recently migraine. More interestingly, acid-sensing ion channels may explain the sex differences in pain between males and females. Read More

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March 2019
2 Reads

Neuroinflammation as a target for glaucoma therapy.

Neural Regen Res 2019 Mar;14(3):391-394

Visual Neurophysiology and Neurophthalmology Research Unit, IRCCS G.B. Bietti Foundation, Roma, Italy.

The pathogenesis of glaucoma is still not fully clarified but a growing body of evidence suggests that neuroinflammation and immune response are part of the sequence of pathological events leading to the optic neuropathy. Indeed, inflammation - involving the activation and proliferation of resident glial cells (astrocytes, Muller cells and microglia) and the release of a plethora of anti- and pro-inflammatory cytokines, chemokines and reactive oxygen species - has been reported as common features in clinical and experimental glaucoma. In the insulted retina, as for other neuronal tissues, pathogenic and reparative aspects coexist in the inflammatory process, with extent and persistency affecting the final outcome. Read More

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Intraocular lens dislocation: a novel in-situ scleral refixation technique using a 25 Gauge trocar in the anterior chamber.

BMJ Open Ophthalmol 2018 23;3(1):e000174. Epub 2018 Nov 23.

Dipartimento Neuromuscoloscheletrico e Organi di Sensi, Università degli Study di Firenze, Florence, Italy.

Objective: Intraocular lens (IOL) repositioning using a closed-eye approach could be carried out in some selected cases. Our study focuses on the efficacy and safety of a IOL closed-eye repositioning technique using scleral suture, which is performed using a trocar as an intrastromal limbal guide.

Methods And Analysis: Thirty-one eyes of 31 patients with late IOL dislocation operated on between January 2015 and May 2017 were included in this retrospective non-comparative consecutive case series study. Read More

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November 2018
1 Read

In glaucoma patients, low blood pressure is accompanied by vascular dysregulation.

EPMA J 2018 Dec 12;9(4):387-391. Epub 2018 Nov 12.

Department of Ophthalmology, University of Basel, Mittlere Strasse 91, CH-4031 Basel, Switzerland.

Background: There are many risk factors contributing to glaucomatous optic neuropathy. Beside increased intraocular pressure, vascular factors play a prominent role, particularly low blood pressure (BP), and vascular dysregulation. Both of them are essential components of the Flammer syndrome. Read More

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December 2018

Better tolerance of preservative-free latanoprost compared to preserved glaucoma eye drops: the 12-month real-life FREE study.

Clin Ophthalmol 2018 26;12:2399-2407. Epub 2018 Nov 26.

Department of Ophtalmology, Claude Huriez Hospital, University Hospital, Lille, France.

Background: Lack of efficacy due to bad compliance caused by intolerance issues is the main reason for a change to a better tolerated ocular treatment, such as using preservative-free (PF) eye drops.

Aim: To assess the efficacy and local tolerance after 12 months and patient satisfaction regarding local treatment tolerance and handling at inclusion and after 6 months of PF latanoprost compared to preserved glaucoma eye drops.

Methods: This was an international, prospective, and observational real-life study. Read More

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November 2018

Efficacy of the travoprost/timolol fixed combination versus the concomitant use of travoprost 0.004% and timolol 0.1% gel formulation.

Clin Ophthalmol 2018 23;12:2393-2398. Epub 2018 Nov 23.

University of Alcala, Madrid, Spain.

Purpose: To compare the hypotensive effect of travoprost 0.004%/timolol 0.5% fixed combination (TTFC) to the concomitant use of travoprost and timolol 0. Read More

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November 2018

Safety of high-dose intravitreal triamcinolone acetonide as low-cost alternative to anti-vascular endothelial growth factor agents in lower-middle-income countries.

Clin Ophthalmol 2018 26;12:2383-2391. Epub 2018 Nov 26.

Department of Ophthalmology, Faculty of Medicine, Benha University, Benha, Egypt.

Purpose: The purpose of this study was to evaluate the safety of high-dose intravitreal triamcinolone acetonide (IVTA) as affordable low-cost alternative to anti-vascular endothelial growth factor (anti-vascular endothelial growth factor [anti-VEGF] agents) in lower-middle-income countries.

Patients And Methods: This was a retrospective interventional non-comparative case series. The study recruited patients who received 20 mg IVTA for treating various retinal and optic nerve diseases over the past 5 years. Read More

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November 2018

Synthesis and characterization of novel substituted thiophene derivatives and discovery of their carbonic anhydrase and acetylcholinesterase inhibition effects.

J Biochem Mol Toxicol 2018 Dec 10:e22261. Epub 2018 Dec 10.

Department of Chemistry, Faculty of Science, Ataturk University, Erzurum, Turkey.

Novel substituted thiophene derivatives (1, 2a-e, 3, and 4) were synthesized and their structures were characterized by infrared radiation, nuclear magnetic resonance, and mass analysis. These novel substituted thiophene derivatives were effective inhibitor compounds of the carbonic anhydrase I and II isozymes (hCA I and II), and acetylcholinesterase (AChE) enzyme with K values in the range of 447.28 to 1004. Read More

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December 2018
1.925 Impact Factor

Thermo-sensitive nanogel-laden bicontinuous microemulsion drug-eluting contact lenses.

J Biomed Mater Res B Appl Biomater 2018 Dec 7. Epub 2018 Dec 7.

Department of Biomedical Engineering, School of Medicine, Catholic University of Daegu, Daegu, 42472, South Korea.

The bicontinuous microemulsion contact lens (BMCL) has nanoporous biphasic structures (100-250 nm) that are interconnected via multiple nano-channels, providing suitable retention of various drugs for glaucoma. Timolol maleate (TM)-carried thermosensitive poly(N-isopropylacrylamide) (PNIPAM) nanogel (30-50 nm) was incorporated into BMCLs by soaking or by centrifuging plus soaking. Here, we present drug-loading and release in silicon- or polyethylene oxide-microemulsion BMCLs under various conditions. Read More

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December 2018
1 Read

Non-linear Relationship between Blood Pressure and Glaucoma in US Adults.

Am J Hypertens 2018 Dec 8. Epub 2018 Dec 8.

Department of Medicine and Program in Public Health, University of California, Irvine, USA.

Background: Previous studies have reported that vascular disease is associated with glaucoma. However, the relationship between blood pressure (BP) and glaucoma has been inconsistent. We investigated whether there is a non-linear association between BP and glaucoma in an adult population of the United States. Read More

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December 2018
2 Reads

Genome-wide association analyses identify 139 loci associated with macular thickness in the UK Biobank cohort.

Hum Mol Genet 2018 Dec 7. Epub 2018 Dec 7.

Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, IL, USA.

The macula, located near the center of the retina in the human eye, is responsible for providing critical functions, such as central, sharp vision. Structural changes in the macula are associated with many ocular diseases, including age-related macular degeneration (AMD) and glaucoma. Although macular thickness is a highly heritable trait, there are no prior reported genome-wide association studies (GWASs) of it. Read More

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December 2018

[A model of ophthalmological network care including primary care centers and a tertiary care hospital].

Rev Med Chil 2018 Aug;146(8):890-893

Servicio de Oftalmología, Hospital del Salvador, Santiago, Chile.

Background: Primary care units of ophtalmology (UAPO) were incorporated in 2003 into the healthcare system of the Ministry of Health, in response to the high demand for hospital care. Three of these primary care units were incorporated to provide a network care with the ophthalmology service of a tertiary care hospital.

Aim: To report the public health impact of networking. Read More

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New perspectives in the use of laser diode transscleral cyclophotocoagulation. A prospective single center observational cohort study.

Rom J Morphol Embryol 2018 ;59(3):869-872

Department of Neurology, "Victor Babeş" University of Medicine and Pharmacy, "Pius Brînzeu" Emergency County Clinical Hospital, Timişoara, Romania; Department of Ophthalmology, "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania;

Purpose: The paper intends to present the results of using new methods of a new generation diode laser transscleral cyclophotocoagulation (TSCPC) in patients with different types of glaucoma.

Patients, Materials And Methods: There have been treated 53 eyes from 59 patients with glaucoma refractory to medical, laser or surgical treatment. We have used the newest generation of 810 nm wavelength diode laser. Read More

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January 2018