17,187 results match your criteria Glaucoma Pigmentary


Elevated Plasma Levels of Drebrin in Glaucoma Patients With Neurodegeneration.

Front Neurosci 2019 3;13:326. Epub 2019 Apr 3.

State Key Laboratory of Ophthalmology, Optometry and Visual Science, The Eye Hospital of Wenzhou Medical University, Wenzhou, China.

Glaucoma is an optic neuropathy characterized by progressive degeneration of retinal ganglion cells (RGCs). Aberrations in several cytoskeletal proteins, such as tau have been implicated in the pathogenesis of neurodegenerative diseases, could be initiating factors in glaucoma progression and occurring prior to axon degeneration. Developmentally regulated brain protein (Drebrin or DBN1) is an evolutionarily conserved actin-binding protein playing a prominent role in neurons and is implicated in neurodegenerative diseases. Read More

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http://dx.doi.org/10.3389/fnins.2019.00326DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456690PMC

Mutant RAMP2 causes primary open-angle glaucoma via the CRLR-cAMP axis.

Genet Med 2019 Apr 19. Epub 2019 Apr 19.

The Key Laboratory for Human Disease Gene Study of Sichuan Province and Department of Laboratory Medicine, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan, China.

Purpose: Primary open-angle glaucoma (POAG) is the leading cause of irreversible blindness worldwide and mutations in known genes can only explain 5-6% of POAG. This study was conducted to identify novel POAG-causing genes and explore the pathogenesis of this disease.

Methods: Exome sequencing was performed in a Han Chinese cohort comprising 398 sporadic cases with POAG and 2010 controls, followed by replication studies by Sanger sequencing. Read More

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http://www.nature.com/articles/s41436-019-0507-0
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http://dx.doi.org/10.1038/s41436-019-0507-0DOI Listing
April 2019
1 Read

Color visual acuity in preperimetric glaucoma and open-angle glaucoma.

PLoS One 2019 17;14(4):e0215290. Epub 2019 Apr 17.

Department of Ophthalmology, Tohoku University Graduate School of Medicine, Sendai, Japan.

Purpose: To investigate the clinical significance of color visual acuity (CVA) in preperimetric glaucoma (PPG) and open-angle glaucoma (OAG).

Methods: A total of 123 eyes of 73 subjects (22 normal eyes, 14 PPG eyes, and 87 OAG eyes; mean age: 44.9 ± 10. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215290PLOS
April 2019
1 Read

Detection of proteins associated with extracellular matrix regulation in the aqueous humour of patients with primary glaucoma.

Curr Eye Res 2019 Apr 17. Epub 2019 Apr 17.

a R.S. Mehta Jain Department of Biochemistry and Cell Biology , KBIRVO, Vision Research Foundation, Sankara Nethralaya , Chennai , India .

Purpose: The protein composition of aqueous humour (AH) has held significant relevance and remains to be the prime sample in the discovery of biomarkers in glaucoma. The purpose of this study is to analyze the aqueous humour protein concentrations in primary open angle glaucoma (POAG) and primary angle closure glaucoma (PACG) and further examine the proteome changes compared to cataract control.

Methods: Aqueous humour was collected from 90 POAG, 72 PACG, 78 cataract (control) in this study. Read More

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http://dx.doi.org/10.1080/02713683.2019.1608261DOI Listing
April 2019
1.663 Impact Factor

The protective variant rs7173049 at LOXL1 locus impacts on retinoic acid signaling pathway in pseudoexfoliation syndrome.

Hum Mol Genet 2019 Apr 15. Epub 2019 Apr 15.

Department of Ophthalmology, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.

LOXL1 (lysyl oxidase-like 1) has been identified as the major effect locus in pseudoexfoliation (PEX) syndrome, a fibrotic disorder of the extracellular matrix and frequent cause of chronic open-angle glaucoma. However, all known PEX-associated common variants show allele effect reversal in populations of different ancestry, casting doubt on their biological significance. Based on extensive LOXL1 deep sequencing, we report here the identification of a common noncoding sequence variant, rs7173049A>G, located downstream of LOXL1, consistently associated with a decrease in PEX risk (OR=0. Read More

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https://academic.oup.com/hmg/advance-article/doi/10.1093/hmg
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http://dx.doi.org/10.1093/hmg/ddz075DOI Listing
April 2019
5 Reads

Mapping mRNA expression of glaucoma genes in the healthy mouse eye.

Curr Eye Res 2019 Apr 12. Epub 2019 Apr 12.

a University Eye Clinic Maastricht, Maastricht University Medical Center , Maastricht , the Netherlands.

Purpose/Aim: Many genes have been associated with primary open-angle glaucoma (POAG). Knowing exactly where they are expressed in the eye helps to unravel POAG pathology and to select optimal targets for intervention. We investigated whether RNA in-situ hybridization (RNA-ISH) is a convenient technique to obtain detailed pan-ocular expression data of these genes. Read More

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http://dx.doi.org/10.1080/02713683.2019.1607392DOI Listing

Clinical application of NGS-based SNP haplotyping for the preimplantation genetic diagnosis of primary open angle glaucoma.

Syst Biol Reprod Med 2019 Apr 12:1-6. Epub 2019 Apr 12.

b Prenatal Diagnosis Centre , Northwest Women's and Children's Hospital , Xi'an , China.

The current study describes a successful case of preimplantation genetic diagnosis (PGD) of primary open angle glaucoma (POAG) and verifies the efficiency of next-generation sequencing (NGS)-based haplotyping for PGD of POAG. In this study, we applied NGS as part of PGD to effectively detect POAG prior to embryo implantation and avoid the prospect of pregnancy termination in event of vertical inheritance of POAG. We used the technique of multiple annealing and looping based amplification cycles (MALBAC) to conduct whole genome amplification (WGA) and to reduce the allele dropout (ADO). Read More

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https://www.tandfonline.com/doi/full/10.1080/19396368.2019.1
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http://dx.doi.org/10.1080/19396368.2019.1590479DOI Listing
April 2019
2 Reads

Randomized crossover trial comparing effectiveness and tolerability of generic and brand-name travoprost.

Can J Ophthalmol 2019 Apr 22;54(2):223-228. Epub 2018 Jun 22.

Department of Ophthalmology, Centre Hospitalier Universitaire de Sherbrooke - Hôtel-Dieu, University of Sherbrooke, Sherbrooke, Quebec.

Objective: The primary goal is to determine if the intraocular pressure reducing effect of generic Sandoz travoprost is equivalent to that of brand-name Travatan Z. The secondary goal is to determine if generic Sandoz travoprost is as well tolerated as Travatan Z.

Methods: This prospective randomized crossover trial allocated 76 patients with primary open-angle glaucoma, normotensive glaucoma, or ocular hypertension in a 1:1 ratio to start with either generic Sandoz travoprost or Travatan Z. Read More

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http://dx.doi.org/10.1016/j.jcjo.2018.04.017DOI Listing
April 2019
1 Read

Evaluation of dynamic thiol-disulfide homeostasis in glaucoma patients and the correlation with retinal nerve fiber layer analysis.

Eur J Ophthalmol 2019 Apr 12:1120672119839582. Epub 2019 Apr 12.

3 Biochemistry Department, Ankara Atatürk Education and Research Hospital, Ankara, Turkey.

Purpose: The aim of this study was to evaluate thiol/disulfide homeostasis and ischemia-modified albumin levels with primary open-angle glaucoma, ocular hypertension, and control group; also to interpret the correlation between these biochemical parameters and retinal nerve fiber layer analysis.

Material And Methods: In a prospective cross-sectional study, 30 primary open-angle glaucoma cases, 30 ocular hypertension cases, and 30 control subjects were included in the study. Native thiol, total thiol, and disulfide measurements and disulfide/native thiol, disulfide/total thiol, and native thiol/total thiol ratios were evaluated as thiol-disulfide homeostasis. Read More

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http://dx.doi.org/10.1177/1120672119839582DOI Listing
April 2019
1 Read

Nailfold Capillaroscopy of Resting Peripheral Blood Flow in Exfoliation Glaucoma and Primary Open-Angle Glaucoma.

JAMA Ophthalmol 2019 Apr 11. Epub 2019 Apr 11.

Einhorn Clinical Research Center, Department of Ophthalmology, New York Eye and Ear Infirmary of Mount Sinai, New York.

Importance: Systemic blood flow alterations have been described using video nailfold capillaroscopy (NFC) in high-tension glaucoma (HTG) and normal-tension glaucoma (NTG) variants of primary open-angle glaucoma (POAG). To date, no previous studies have explored alterations in nailfold capillary blood flow in exfoliation glaucoma (XFG).

Objective: To investigate the measure of peripheral blood flow as a surrogate marker of systemic vascular involvement in patients with XFG, HTG, and NTG, as well as in individuals serving as controls, using NFC. Read More

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http://dx.doi.org/10.1001/jamaophthalmol.2019.0434DOI Listing
April 2019
1 Read

Polygenic Risk Score Is Associated With Intraocular Pressure and Improves Glaucoma Prediction in the UK Biobank Cohort.

Transl Vis Sci Technol 2019 Apr 4;8(2):10. Epub 2019 Apr 4.

Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, IL, USA.

Purpose: Elevated intraocular pressure (IOP) is an important risk factor for glaucoma. We constructed polygenic risk scores (PRSs) for IOP using the UK Biobank (UKB) data set to test whether the PRSs are associated with IOP and whether using them improves glaucoma prediction.

Methods: We conducted this study using 435,678 European participants from the UKB. Read More

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http://dx.doi.org/10.1167/tvst.8.2.10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6450641PMC

Correlation between structural progression in glaucoma and obstructive sleep apnea.

Eye (Lond) 2019 Apr 10. Epub 2019 Apr 10.

Department of Ophthalmology, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taoyuan, Taiwan.

Background/objectives: To investigate the correlation between obstructive sleep apnea (OSA) severity and the structural and functional progression in patients with glaucoma.

Subjects/methods: This retrospective comparative cohort study included subjects from the polysomnography database in Chang Gung Memorial Hospital between June 1, 2009, and June 1, 2017, by identifying patients who had received diagnoses of primary open-angle glaucoma (POAG), normal-tension glaucoma (NTG), or glaucoma suspect. Patients with follow-up time of <3 years and/or <3 consecutive reliable optical coherence tomography (OCT) or visual field (VF) tests were excluded. Read More

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http://dx.doi.org/10.1038/s41433-019-0430-2DOI Listing
April 2019
3 Reads

Interaction between XRCC 1 gene polymorphisms and diabetes on susceptibility to primary open-angle glaucoma.

Exp Biol Med (Maywood) 2019 Apr 11:1535370219842791. Epub 2019 Apr 11.

Department of Ophthalmology, Second Hospital of Jilin University, Jilin University, Changchun 130041, China.

Impact Statement: Some studies have suggested that diabetes and XRCC gene may be risk factors for glaucoma; however, no studies have focused on the interaction between the XRCC gene and T2DM with respect to POAG risk. Therefore, the present study evaluated the initiative gene-environment interactions in POAG. Read More

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http://dx.doi.org/10.1177/1535370219842791DOI Listing

Comparison of cytokine/chemokine levels in aqueous humor of primary open-angle glaucoma patients with positive or negative outcome following trabeculectomy.

Biosci Rep 2019 Apr 9. Epub 2019 Apr 9.

Rostock University Medical Center, Rostock, Germany.

We aimed to identify differences in cytokine/chemokine levels in the aqueous humor (AH) of primary open-angle glaucoma (POAG) patients who suffered from scarring, compared to POAG patients with no scarring after trabeculectomy surgery. Identification of differently expressed cytokines and chemokines may help to understand scarring and fibrotic processes following trabeculectomy, and to make predictions for the outcome of fistulating surgery in the future. Furthermore, the identification of cell signaling pathways involved in fibrosis offers the opportunity for a more specific antifibrotic therapy with reduced side effects, and an improvement in long-term surgical outcome. Read More

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http://dx.doi.org/10.1042/BSR20181894DOI Listing

Possible Role of Differentially Expressing Novel Protein Markers (Ligatin and Fibulin-7) in Human Aqueous Humor and Trabecular Meshwork Tissue in Glaucoma Progression.

Cell Biol Int 2019 Apr 8. Epub 2019 Apr 8.

Biochemistry and Environmental Toxicology, Laboratory # 103, School of Environmental Sciences, Jawaharlal Nehru University, New Delhi, India.

The pathological mechanism underlying glaucoma has always been a complex aspect of this permanently blinding disease but proteomic studies have been helpful in elucidating it to a great extent in several studies. This study was designed to evaluate the expression and to get an idea about the function of two novel markers (Ligatin and Fibulin-7) identified in human aqueous humor (hAH) in relation to glaucomatous progression. A significant increase in the protein content of glaucomatous hAH compared to that of non-glaucomatous controls (NG-Ctrls) was observed. Read More

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http://dx.doi.org/10.1002/cbin.11138DOI Listing
April 2019
1 Read
1.933 Impact Factor

Prevalence and Clinical Characteristics of Childhood Glaucoma at A Tertiary Care Children's Hospital.

J Glaucoma 2019 Apr 3. Epub 2019 Apr 3.

Akron Children's Hospital, Akron OH.

Precis: Glaucoma suspect was the most prevalent category in this study followed by glaucoma associated with acquired ocular anomaly and juvenile open-angle glaucoma. Primary congenital glaucoma was diagnosed in only 3% of the population studied.

Purpose: To describe the prevalence and clinical characteristics of childhood glaucoma diagnosed over a 10-year period among patients ≤18 years of age who were seen at a tertiary care children's hospital using the new Childhood Glaucoma Research Network (CGRN) classification system. Read More

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http://dx.doi.org/10.1097/IJG.0000000000001259DOI Listing

Endothelin-1 Concentration in Aqueous Humor Predicts Postoperative Late Low Intraocular Pressure in Primary Open Angle Glaucoma After Trabeculectomy.

J Glaucoma 2019 Apr 3. Epub 2019 Apr 3.

Department of Ophthalmology, XiangYang NO.1 People's Hospital, Affiliated Hospital of Hubei University of Medicine.

Background: This study aimed to evaluate potential risk factors for postoperative late low intraocular pressure (IOP) in patients with primary open angle glaucoma (POAG) after trabeculectomy.

Methods: Adult patients who were diagnosed with POAG and scheduled to perform primary unilateral trabeculectomy in our hospital were consecutively included. Blood samples prior to the surgery and aqueous humor samples during the surgery of each participant were collected. Read More

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http://dx.doi.org/10.1097/IJG.0000000000001254DOI Listing

Clinicopathologic Examination of Translucent Refractile Intraluminal Tissue Coagulum From the Proximal Tube of a Baerveldt Glaucoma Drainage Device.

J Glaucoma 2019 Apr;28(4):e64-e65

Birmingham Institute for Glaucoma Research, Institute of Translational Medicine, University Hospitals Birmingham NHS Foundation Trust, Birmingham.

Purpose: To describe an unusual case of glaucoma drainage tube blockage.

Patients: A 76-year-old woman presented with left endothelial graft failure. Her previous ocular history included primary open-angle glaucoma diagnosed for 15 years and Fuch's endothelial dystrophy. Read More

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http://dx.doi.org/10.1097/IJG.0000000000001148DOI Listing
April 2019
2 Reads

Effect of Mannitol on Intraocular Pressure in Vitrectomized and Nonvitrectomized Eyes: A Prospective Comparative Study.

J Glaucoma 2019 Apr;28(4):318-320

Glaucoma Services, Aravind Eye Hospital, Coimbatore, Tamil Nadu, India.

Purpose: To compare the effect of mannitol in reducing intraocular pressure (IOP) in vitrectomized and nonvitrectomized eyes.

Materials And Methods: Prospective comparative case study. Eyes with IOP≥40 mm Hg were included. Read More

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http://dx.doi.org/10.1097/IJG.0000000000001158DOI Listing

Macular ganglion cell-inner plexiform vs retinal nerve fiber layer measurement to detect early glaucoma with superior or inferior hemifield defects.

J Chin Med Assoc 2019 Apr;82(4):335-339

Department of Ophthalmology, Taipei Veterans General Hospital, Taipei, Taiwan, ROC.

Background: To compare the diagnostic ability of Cirrus high-definition spectral-domain optical coherence tomography measurements of the macular ganglion cell-inner plexiform layer (GCIPL) vs the circumferential retinal nerve fiber layer (cpRNFL) to detect early glaucoma with hemifield visual field (VF) defects.

Methods: This prospective study included 96 patients with primary open-angle glaucoma (48 with superior hemifield defects and 48 with inferior hemifield defects) and 48 normal control subjects. All glaucomatous eyes had a mean deviation of the VF defect ≥-6. Read More

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http://dx.doi.org/10.1097/JCMA.0000000000000037DOI Listing
April 2019
1 Read

Changes in ocular signs and symptoms in patients switching from bimatoprost-timolol to tafluprost-timolol eye drops: an open-label phase IV study.

BMJ Open 2019 Apr 2;9(4):e024129. Epub 2019 Apr 2.

Global Medical Affairs, Santen Oy, Helsinki, Finland.

Objectives: Bimatoprost-timolol (bimatoprost 0.03%-timolol 0.5% fixed-dose combination [FDC]) and tafluprost-timolol (tafluprost 0. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-024129DOI Listing
April 2019
1 Read

Early results of micropulse transscleral cyclophotocoagulation for the treatment of glaucoma.

Eur J Ophthalmol 2019 Apr 2:1120672119839303. Epub 2019 Apr 2.

1 Department of Ophthalmology and Visual Science, Yale School of Medicine, New Haven, CT, USA.

Purpose:: To describe our clinical experience with the efficacy and safety of micropulse transscleral cyclophotocoagulation as a treatment for glaucoma.

Methods:: In this retrospective case series, we reviewed the charts of 95 consecutive patients with various glaucoma subtypes who underwent micropulse transscleral cyclophotocoagulation. Patients were offered micropulse transscleral cyclophotocoagulation if they had perimetric glaucoma refractory to intraocular pressure-lowering topical medications and who were poor candidates for traditional filtering surgery. Read More

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http://dx.doi.org/10.1177/1120672119839303DOI Listing
April 2019
12 Reads

One-year outcomes following implantation of second-generation trabecular micro-bypass stents in conjunction with cataract surgery for various types of glaucoma or ocular hypertension: multicenter, multi-surgeon study.

Clin Ophthalmol 2019 13;13:491-499. Epub 2019 Mar 13.

Hunter Cataract & Eye Centre, Sydney, NSW, Australia.

Purpose: To assess the utility and safety of implanting two second-generation trabecular micro-bypass stents following cataract surgery in eyes with mild to advanced glaucoma or ocular hypertension (OHT).

Patients And Methods: Retrospective study of iStentinject trabecular micro-bypass implantation with cataract surgery by five surgeons at five sites in Australia. Eyes had mild to advanced glaucoma (predominantly primary open-angle, appositional angle-closure, or pseudoexfoliative glaucoma) or OHT and cataract requiring surgery. Read More

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http://dx.doi.org/10.2147/OPTH.S187272DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6420788PMC

2019 New Drug Update.

Sr Care Pharm 2019 Apr;34(4):230-242

Five new drugs marketed in 2018 that are used for medical problems often experienced by the elderly have been selected for consideration in this review. The uses and most important properties of these agents are discussed, and a rating for each new drug is determined using the New Drug Comparison Rating system developed by the author (DAH). Advantages, disadvantages, and other important information regarding each new drug are identified and used as the basis for determining the rating. Read More

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https://www.ingentaconnect.com/content/10.4140/TCP.n.2019.23
Publisher Site
http://dx.doi.org/10.4140/TCP.n.2019.230.DOI Listing
April 2019
3 Reads

Correlation of the Retinal Parapapillary Perfusion and the Retinal Vessel Oxygen Saturation in Glaucoma Patients.

Invest Ophthalmol Vis Sci 2019 Apr;60(5):1309-1315

Department of Ophthalmology, Jena University Hospital, Jena, Germany.

Purpose: Reduced perfusion of the retinal parapapillary tissue is well documented in glaucoma patients. Whether or not this is a cause or result of the disease is however unknown. Studying the correlation of this perfusion and the retinal vascular oxygen saturation (O2S) could give clues to the retinal O2 consumption/demand and provide an answer to this question. Read More

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http://dx.doi.org/10.1167/iovs.18-26099DOI Listing

The LRRC8-mediated volume-regulated anion channel is altered in glaucoma.

Sci Rep 2019 Apr 1;9(1):5392. Epub 2019 Apr 1.

Neurophysiology Laboratory, Physiology Unit, Department of Biomedicine, Medical School, University of Barcelona, Casanova 143, E-08036, Barcelona, Spain.

Regulation of cellular volume is an essential process to balance volume changes during cell proliferation and migration or when intracellular osmolality increases due to transepithelial transport. We previously characterized the key role of volume-regulated anion channels (VRAC) in the modulation of the volume of trabecular meshwork (TM) cells and, in turn, the aqueous humour (AH) outflow from the eye. The balance between the secretion and the drainage of AH determines the intraocular pressure (IOP) that is the major casual risk factor for glaucoma. Read More

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http://dx.doi.org/10.1038/s41598-019-41524-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443673PMC

[Impact of glaucoma medications and ocular surface disease on the quality of life of glaucoma patients in the district of Sousse (Tunisia)].

J Fr Ophtalmol 2019 Mar 27. Epub 2019 Mar 27.

Service d'ophtalmologie, CHU Farhat Hached, Sousse Tunisie.

Purpose: To assess the impact of glaucoma treatment and ocular surface disease (OSD) on the vision-specific quality-of-life (VS-QoL) of glaucoma patients attending Farhat Hached university hospital Sousse-Tunisia.

Methods: This was a cross-sectional study enrolling one-hundred-twenty patients followed for primary open angle glaucoma. All patients successfully responded to the Arabic version of the National Eye Institute Visual Function Questionnaire 25 (NEI-VFQ 25). Read More

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http://dx.doi.org/10.1016/j.jfo.2018.06.007DOI Listing

Macula Vessel Density and Foveal Avascular Zone Parameters in Exfoliation Glaucoma Compared to Primary Open-Angle Glaucoma.

Invest Ophthalmol Vis Sci 2019 Mar;60(4):1244-1253

Einhorn Clinical Research Center, Department of Ophthalmology, New York Eye and Ear Infirmary of Mount Sinai, New York, New York, United States.

Purpose: The purpose of this study was to explore macula vessel density and foveal avascular zone (FAZ) parameters in exfoliation glaucoma (XFG) compared to primary open-angle glaucoma (POAG) using optical coherence tomography angiography (OCTA).

Methods: This was a cross-sectional observational study. Twenty-six XFG and 28 POAG patients with comparable visual field defects on Humphrey 24-2 and 10-2 perimetries were recruited. Read More

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http://dx.doi.org/10.1167/iovs.18-25986DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440528PMC

Effect of combined goniotomy and phacoemulsification on intraocular pressure in open-angle glaucoma patients.

Clin Exp Ophthalmol 2019 Mar 28. Epub 2019 Mar 28.

Department of Ophthalmology, Chungnam National University Hospital, Daejeon, Korea.

Importance: Although goniotomy is known to be successful in treating congenital glaucoma, its effect in adult glaucoma patients remains unclear.

Background: To evaluate the efficacy and safety of goniotomy performed simultaneously with cataract surgery in treatment of open-angle glaucoma (OAG).

Design: Retrospective comparative study. Read More

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http://dx.doi.org/10.1111/ceo.13506DOI Listing
March 2019
1 Read

A case of latanoprost-induced diffuse facial skin hyperpigmentation.

J Cosmet Dermatol 2019 Mar 28. Epub 2019 Mar 28.

Department of Dermatology, Sanggye Paik Hospital, Inje University, Seoul, Korea.

Introduction: Latanoprost is a prostaglandin F2α analogue, which has been used as a first-line drug for open-angle glaucoma. Common side effects of latanoprost include hyperpigmentation. While it usually occurs on irides or periocular skin, diffuse facial hyperpigmentation is rarely reported. Read More

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http://dx.doi.org/10.1111/jocd.12920DOI Listing
March 2019
5 Reads

Ocular Surface Evaluation After the Substitution of Benzalkonium Chloride Preserved Prostaglandin Eye Drops by a Preservative-free Prostaglandin Analogue.

Med Hypothesis Discov Innov Ophthalmol 2019 ;8(1):52-56

Department of Ophthalmology, Federal University of Brasilia, Brasilia, Brazil.

To evaluate ocular surface changes after withdrawal of Benzalkonium chloride (BAK) in patients with glaucoma in monotherapy with BAK-preserved prostaglandin. This was a prospective observational study. All patients underwent complete ophthalmologic examination and evaluation of ocular surface. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6433198PMC
January 2019

The Effect of Glaucoma Medication on Choroidal Thickness Measured with Enhanced Depth-Imaging Optical Coherence Tomography.

Med Hypothesis Discov Innov Ophthalmol 2019 ;8(1):44-51

Department of Bioistatistics, Ataturk University, Erzurum, Turkey.

The aim of this study was to examine the effect of the glaucoma medication on Choroidal Thickness (CT) in those with Primary Open-Angle Glaucoma (POAG) and normal cases. This prospective study included 27 patients with newly diagnosed POAG (group 1; 49 eyes), undergoing glaucoma treatment, and 30 patients, whose treatment was terminated due to misdiagnosis (group 2; 57 eyes). Choroidal thickness was measured using Enhanced Depth Imaging (EDI) with Spectral Domain Optical Coherence Tomography (SD-OCT) at the first visit and almost one month later. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6433202PMC
January 2019
1 Read

Association of the Myocilin Gene Polymorphism With Primary Open Angle Glaucoma.

Med Hypothesis Discov Innov Ophthalmol 2019 ;8(1):28-33

Eye Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

Glaucoma is the second cause of irreversible blindness, and the Primary Open Angle Glaucoma (POAG) subtype is the most common type of glaucoma. It has been shown that genetic mutations increase the risk of POAG used for early detection. The aim of the current study was to determine the association between genetic variations of Myocilin (MYOC) gene and susceptibility to POAG in the Iranian population. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6433201PMC
January 2019

Corneal biomechanics and biomechanically corrected intraocular pressure in primary open-angle glaucoma, ocular hypertension and controls.

Br J Ophthalmol 2019 Mar 28. Epub 2019 Mar 28.

Biomedical Sciences Research Institute, University of Ulster, Coleraine, UK.

Aims: To compare the biomechanically corrected intraocular pressure (IOP) estimate (bIOP) provided by the Corvis-ST with Goldmann applanation tonometry (GAT-IOP) in patients with high-tension and normal-tension primary open-angle glaucoma (POAG; HTG and NTG), ocular hypertension (OHT) and controls. Moreover, we compared dynamic corneal response parameters (DCRs) of the Corvis-ST in POAG, OHT and controls, evaluated the correlation between global visual field parameters mean deviation and pattern SD (MD and PSD) and DCRs in the POAG group.

Methods: 156 eyes of 156 patients were included in this prospective, single-centre, observational study, namely 41 HTG and 33 NTG, 45 OHT cases and 37 controls. Read More

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http://dx.doi.org/10.1136/bjophthalmol-2018-313493DOI Listing
March 2019
3 Reads

West Indies Glaucoma Laser Study (WIGLS) 3. Anterior Chamber Inflammation Following Selective Laser Trabeculoplasty in Afro-Caribbeans with Open-Angle Glaucoma.

J Glaucoma 2019 Mar 26. Epub 2019 Mar 26.

Department of Epidemiology, Epidemiology Data Center, Graduate School of Public Health, University of Pittsburgh, PA.

Precis: In the absence of prophylactic anti-inflammatory therapy, anterior chamber inflammation (characterized by cells and less commonly flare) is minimal and transient after selective laser trabeculoplasty in Afro-Caribbean glaucoma patients.

Purpose: To characterize the prevalence, severity, and duration of anterior chamber inflammation (cells and flare) following selective laser trabeculoplasty (SLT) in Afro-Caribbean eyes with primary open-angle glaucoma (POAG).

Methods: 144 eyes of 72 POAG patients underwent first-time 360-degree SLT treatment following washout of all topical medications in the prospective West Indies Glaucoma Laser Study. Read More

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http://dx.doi.org/10.1097/IJG.0000000000001250DOI Listing

Non-inferiority of Preservative-free versus BAK-preserved Latanoprost-timolol Fixed Combination Eye Drops in Patients with Open-angle Glaucoma or Ocular Hypertension.

J Glaucoma 2019 Mar 26. Epub 2019 Mar 26.

University Hospitals UZ Leuven, Ophthalmology Department, Leuven, Belgium.

Precis: Non-inferiority of efficacy was demonstrated for a preservative-free latanoprost-timolol fixed combination compared to a BAK-containing formulation at 84 days after treatment in patients with open-angle glaucoma or ocular hypertension.

Purpose: To compare the effect on intraocular pressure and safety of preservative-free latanoprost-timolol fixed combination (T2347) to benzalkonium chloride-preserved latanoprost-timolol fixed combination in patients with open-angle glaucoma or ocular hypertension.

Methods: Phase III,randomizedd, parallel-group, investigator-masked study in 10 countries. Read More

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http://Insights.ovid.com/crossref?an=00061198-900000000-9816
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http://dx.doi.org/10.1097/IJG.0000000000001248DOI Listing
March 2019
3 Reads

Influence of Anterior Biometry on Corneal Biomechanical Stiffness of Glaucomatous eyes Treated with Chronic Medication or Filtration Surgery.

J Glaucoma 2019 Mar 26. Epub 2019 Mar 26.

Imaging, Biomechanics, and Mathematical Modeling Solutions Lab, Narayana Nethralaya Foundation, Bangalore, India.

PRéCIS: Anterior chamber depth, IOP and thickness, confounded assessment of corneal biomechanical properties with non-contact applanation in glaucoma eyes. Compared to normal eyes, glaucoma eyes, which underwent long term treatment or filtration surgery, had similar properties.

Purpose: To evaluate corneal stiffness in primary angle closure (PACG) and primary open angle (POAG) glaucoma eyes sub-grouped based on type of topical medication and filtration surgery using non-contact applanation METHODS:: All eyes were retrospectively reviewed for intraocular pressure (IOP) with Corvis-ST (OCULUS Optikgerate Gmbh, Germany). Read More

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http://dx.doi.org/10.1097/IJG.0000000000001247DOI Listing

Patient Preference-Based Comparative Effectiveness and Cost-Utility Analysis of the Prostamides for Open-Angle Glaucoma.

J Ocul Pharmacol Ther 2019 Apr 28;35(3):145-160. Epub 2019 Mar 28.

1 Center for Value-Based Medicine®, Hilton Head, South Carolina.

Purpose: To perform patient preference-based comparative effectiveness and cost-utility (cost-effectiveness) analyses to evaluate topical bimatoprost 0.01%, latanoprost 0.005%, travoprost 0. Read More

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https://www.liebertpub.com/doi/10.1089/jop.2018.0114
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http://dx.doi.org/10.1089/jop.2018.0114DOI Listing
April 2019
5 Reads

Ab interno trabecular bypass surgery with iStent for open-angle glaucoma.

Cochrane Database Syst Rev 2019 03 28;3:CD012743. Epub 2019 Mar 28.

Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 N. Wolfe Street, E6009, Baltimore, Maryland, USA, 21205.

Background: Glaucoma is a leading cause of irreversible blindness worldwide. In early stages, glaucoma results in progressive loss of peripheral (side) vision; in later stages, it results in loss of central vision leading to blindness. Elevated intraocular pressure (IOP) is the only known modifiable risk factor for glaucoma. Read More

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http://dx.doi.org/10.1002/14651858.CD012743.pub2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437719PMC
March 2019
2 Reads

Short-Term Safety Evaluation of a Multi-Pressure Dial: A Prospective, Open-label, Non-randomized Study.

Ophthalmol Ther 2019 Mar 27. Epub 2019 Mar 27.

Vance Thompson Vision, Sioux Falls, SD, USA.

Introduction: Prospective, open-label, non-randomized, single site study to assess the safety and tolerability of a multi-pressure dial.

Methods: 30 healthy subjects received application of negative pressure (-15 mmHg) in one eye for 30 minutes and ambient atmospheric pressure in the contralateral eye. To evaluate safety, the primary outcome measures included best corrected visual acuity (BCVA), intraocular pressure (IOP) changes from baseline, slit-lamp and dilated fundus examination findings, and rate of adverse events. Read More

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http://dx.doi.org/10.1007/s40123-019-0181-yDOI Listing

Impact of pigment dispersion on trabecular meshwork cells.

Graefes Arch Clin Exp Ophthalmol 2019 Mar 28. Epub 2019 Mar 28.

Department of Ophthalmology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.

Purpose: Dysfunction of the trabecular meshwork (TM) in pigmentary glaucoma contributes to increased aqueous humor outflow resistance and intraocular pressure. In this study, we investigated the effect of pigment dispersion on trabecular meshwork cells.

Methods: Porcine TM cells from ab interno trabeculectomy specimens were exposed to pigment dispersion, then, analyzed for changes in morphology, immunostaining, and ultrastructure. Read More

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http://dx.doi.org/10.1007/s00417-019-04300-7DOI Listing
March 2019
1.908 Impact Factor

Management of the open angle glaucoma in patients with central/hemicentral retinal vein occlusions.

Int J Ophthalmol 2019 18;12(3):436-441. Epub 2019 Mar 18.

Department of Ophthalmology, University of Medicine, Cluj-Napoca 400014, Romania.

Aim: To prospectively assess the cumulative prevalence and management of open angle glaucoma (OAG), including primary open angle glaucoma (POAG) with high and normal-pressure, as well as pseudoexfoliative glaucoma (PEXG), in patients with central/hemicentral retinal vein occlusions (RVOs) over a 3-year follow-up period.

Methods: The study encompassed 57 patients with unilateral acute central/hemicentral RVOs. A complete ophthalmic examination of both eyes was undertaken for all patients. Read More

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http://dx.doi.org/10.18240/ijo.2019.03.14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6423395PMC

Modified viscocanalostomy in the Chinese population with open angle glaucoma: a 10-year follow-up results.

Int J Ophthalmol 2019 18;12(3):429-435. Epub 2019 Mar 18.

Department of Ophthalmology, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu Province, China.

Aim: To study the long-term efficacy and safety of modified viscocanalostomy in Chinese people with open angle glaucoma (OAG).

Methods: This retrospective study included a total of 100 eyes from 100 Chinese patients with medically uncontrolled OAG. All the patients underwent modified viscocanalostomy with injection of viscoelastic material in the surgically created ostia of Schlemm's canal (SC). Read More

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http://dx.doi.org/10.18240/ijo.2019.03.13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6423394PMC

Caveolin-1 regulates human trabecular meshwork cell adhesion, endocytosis, and autophagy.

J Cell Biochem 2019 Mar 27. Epub 2019 Mar 27.

Joint Shantou International Eye Center of Shantou University and the Chinese University of Hong Kong, Shantou, Guangdong, China.

Impaired trabecular meshwork (TM) outflow is implicated in the pathogenesis of primary open-angle glaucoma (POAG). We previously identified the association of a caveolin-1 (CAV1) variant with POAG by genome-wide association study. Here we report a study of CAV1 knockout (KO) effect on human TM cell properties. Read More

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http://dx.doi.org/10.1002/jcb.28613DOI Listing
March 2019
1 Read

Ab externo canaloplasty results and efficacy: a retrospective cohort study with a 12-month follow-up.

Eye Vis (Lond) 2019 12;6. Epub 2019 Mar 12.

1St. Johannes Hospital, Eye clinic, Dortmund, Germany.

Background: The aim of this study is to review the outcomes of canaloplasty versus canaloplasty combined with phacoemulsification in a retrospective cohort study and to evaluate the efficacy of these methods in terms of intraocular pressure (IOP) lowering effect, postoperative complications and additional glaucoma surgery or reintroduction of medical therapy over a 12-month follow-up.

Methods: In a retrospective cohort study, 602 eyes with primary open angle glaucoma (POAG) were treated with canaloplasty or canaloplasty combined with phacoemulsification. The results were evaluated separately in two main groups; group A canaloplasty (262 eyes) and group B canaloplasty combined with phaco (322 eyes). Read More

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http://dx.doi.org/10.1186/s40662-019-0134-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417166PMC

Glaucoma Diagnosis with Machine Learning Based on Optical Coherence Tomography and Color Fundus Images.

J Healthc Eng 2019 18;2019:4061313. Epub 2019 Feb 18.

Tohoku University Graduate School of Medicine, Sendai, Japan.

This study aimed to develop a machine learning-based algorithm for glaucoma diagnosis in patients with open-angle glaucoma, based on three-dimensional optical coherence tomography (OCT) data and color fundus images. In this study, 208 glaucomatous and 149 healthy eyes were enrolled, and color fundus images and volumetric OCT data from the optic disc and macular area of these eyes were captured with a spectral-domain OCT (3D OCT-2000, Topcon). Thickness and deviation maps were created with a segmentation algorithm. Read More

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http://dx.doi.org/10.1155/2019/4061313DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6397963PMC
February 2019
1 Read

Levels of serum trace elements in patients with primary open-angle glaucoma.

J Trace Elem Med Biol 2019 May 15;53:129-134. Epub 2019 Feb 15.

Department of Ophthalmology, University of Erlangen, Schwabachanlage 6, 91054 Erlangen, Germany. Electronic address:

Purpose: Glaucoma disease is known as multifactorial. Trace elements seemed to be linked via oxidative stress mediated changes to the complex glaucoma pathophysiology. Thus, it was the aim of this study to investigate serum levels of trace elements in primary open-angle glaucoma patients (POAG). Read More

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http://dx.doi.org/10.1016/j.jtemb.2019.02.006DOI Listing

Primary Open-angle Glaucoma With Initial Visual Field Damage in the Superior and Inferior Hemifields: Comparison in a Population-based Setting.

J Glaucoma 2019 Mar 22. Epub 2019 Mar 22.

Kanto Central Hospital of the Mutual Aid Association of Public School Teachers.

Purpose: To study differences in systemic and ocular factors between eyes with primary open-angle glaucoma (POAG) with an initial visual field defect (VFD) starting in the superior hemifield and those starting in the inferior hemifield in a population-based setting.

Methods: The data were analyzed from eyes with definitive category-1 POAG based on the International Society of Geographic and Epidemiological Ophthalmology criteria with VFD constriction in the superior or inferior hemifield (superior and inferior VFD groups, respectively) found in two Japanese population-based glaucoma surveys. The VFs were tested using the Humphrey Field Analyzer Central 30-2 or 24-2 Swedish Interactive Thresholding Algorithm Standard program. Read More

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http://dx.doi.org/10.1097/IJG.0000000000001241DOI Listing

Histochemical Analysis of Glaucoma Caused by a Myocilin Mutation in a Human Donor Eye.

Ophthalmol Glaucoma 2018 Sep-Oct;1(2):132-138. Epub 2018 Aug 17.

institute for Vision Research, University of Iowa, Iowa City, IA, USA.

Objective: Mutations in myocilin ( may cause either juvenile open angle glaucoma (JOAG) or adult-onset primary open angle glaucoma (POAG). encodes a glycoprotein that is normally secreted from trabecular meshwork cells that regulate intraocular pressure. Prior transgenic rodent, and organ culture experiments have suggested that abnormal accumulation of MYOC protein within trabecular meshwork cells is a key step in glaucoma pathophysiology. Read More

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http://dx.doi.org/10.1016/j.ogla.2018.08.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425711PMC
August 2018
2 Reads