20,339 results match your criteria Glaucoma Pigmentary


The genetic basis for adult onset glaucoma: Recent advances and future directions.

Prog Retin Eye Res 2022 May 17:101066. Epub 2022 May 17.

Duke-NUS Medical School, Singapore; Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore.

Glaucoma, a diverse group of eye disorders that results in the degeneration of retinal ganglion cells, is the world's leading cause of irreversible blindness. Apart from age and ancestry, the major risk factor for glaucoma is increased intraocular pressure (IOP). In primary open-angle glaucoma (POAG), the anterior chamber angle is open but there is resistance to aqueous outflow. Read More

View Article and Full-Text PDF

Association of Diabetes Medication With Open-Angle Glaucoma, Age-Related Macular Degeneration, and Cataract in the Rotterdam Study.

JAMA Ophthalmol 2022 May 19. Epub 2022 May 19.

Department of Ophthalmology, Erasmus University Medical Center, Rotterdam, the Netherlands.

Importance: Recent studies suggest that the diabetes drug metformin has a protective effect on open-angle glaucoma (OAG) and age-related macular degeneration (AMD). However, studies have not addressed the critical issue of confounding by indication, and associations have not been evaluated in a large prospective cohort.

Objective: To determine the association between diabetes medication and the common eye diseases OAG, AMD, and cataract and to evaluate their cumulative lifetime risks in a large cohort study. Read More

View Article and Full-Text PDF

Platelet Parameters and Their Relationships With the Thickness of the Retinal Nerve Fiber Layer and Ganglion Cell Complex in Primary Open-Angle Glaucoma.

Front Neurol 2022 2;13:867465. Epub 2022 May 2.

Department of Ophthalmology and Visual Science, Shanghai Medical College, Eye and Ear Nose and Throat Hospital, Fudan University, Shanghai, China.

Objective: Glaucoma is a neurodegenerative disease of the visual system. Platelet parameters are correlated with visual field mean deviation (MD) in glaucoma, but there is a lack of relative data on their relationship with structural changes in the retina. This study aimed to explore the relationship between platelet parameters and retinal nerve fiber layer (RNEL), ganglion cell complex (GCC) thickness, and cup/disk area ratio, evaluated by optical coherence tomography (OCT) in primary open-angle glaucoma (POAG). Read More

View Article and Full-Text PDF

Comparison of the Structure-function Relationship Between Advanced Primary Open-angle Glaucoma and Normal-tension Glaucoma.

J Glaucoma 2022 May 16. Epub 2022 May 16.

Department of Ophthalmology and Research Institute of Medical Sciences, Chonnam National University Medical School and Hospital, Gwangju, South Korea.

Purpose: To investigate and compare the characteristics of visual field (VF) defects in primary open-angle glaucoma (POAG) and normal tension glaucoma (NTG) with advanced glaucomatous damage and to determine whether the structure‒function relationships found in advanced glaucoma differ based on their glaucoma classification.

Methods: Ninety-seven eyes of 97 patients (59 eyes with POAG and 38 eyes with NTG) with advanced glaucoma were included in this cross-sectional study. Scores at each test point of the 30-2 VF total deviation map were recorded, and average values at each test point were pointwise compared between the groups. Read More

View Article and Full-Text PDF

Efficacy and Safety of the Preserflo Microshunt ® with Mytomicin C for the Treatment of Open Angle Glaucoma.

J Glaucoma 2022 May 17. Epub 2022 May 17.

Grupo Oftalvist, Alicante , Spain.

Prcis: The PSM® is a safe and effective glaucoma micro-filtering implant that significantly reduces the intraocular pressure, either alone or in combination with phacoemulsification, during the first year after surgery.

Purpose: To assess the safety and efficacy of the Preserflo Microshunt® (PSM®) for the treatment of open angle glaucoma with 0.2▒mg/ml mytomicin C (MMC), either alone or in combination with cataract surgery. Read More

View Article and Full-Text PDF

The role of optical coherence tomography angiography in moderate and advanced primary open-angle glaucoma.

Int Ophthalmol 2022 May 17. Epub 2022 May 17.

Glaucoma Service, Farabi Eye Hospital, Tehran University of Medical Sciences, Qazvin Square, Tehran, Iran.

Purpose: To evaluate the relationship between structure and function in moderate and advanced primary open-angle glaucoma (POAG) and to determine the accuracy of structure and vasculature for discriminating moderate from advanced POAG.

Methods: In this cross-sectional study, 25 eyes with moderate and 40 eyes with advanced POAG were enrolled. All eyes underwent measurement of the thickness of circumpapillary retinal nerve fiber layer (cpRNFL) and macular ganglion cell complex (GCC), and optical coherence tomography angiography (OCTA) of the optic nerve head (ONH) and macula. Read More

View Article and Full-Text PDF

The rs1800795 single nucleotide polymorphism in the IL6 gene is not associated with primary open angle glaucoma in Mexican population.

Arch Soc Esp Oftalmol (Engl Ed) 2022 May 13. Epub 2022 May 13.

Tecnológico de Monterrey, Escuela de Medicina y Ciencias de la Salud, Campus Guadalajara, Zapopan, Jalisco, Mexico. Electronic address:

Purpose: Interleukin-6 (IL-6) is a proinflammatory cytokine with pleiotropic effects which has been related to primary open angle glaucoma (POAG) due to its particular effect of protecting the retinal ganglion cells (RGc) from the apoptosis. Different single nucleotide polymorphisms (SNP) have been associated with POAG. The aim of this study was to determine whether an association between IL-6 rs1800795 (-174 G>C) SNP and a higher risk for POAG is present in western Mexican population. Read More

View Article and Full-Text PDF

NEDD9 Mediates the FAK/Src Signaling Pathway to Promote the Adhesion of Human Trabecular Meshwork Cells after Dexamethasone Treatment.

Curr Eye Res 2022 May 16:1-9. Epub 2022 May 16.

The First Affiliated Hospital of Chongqing Medical University, Chongqing Key Lab of Ophthalmology, Chongqing Eye Institute, Chongqing Branch of National Clinical Research Center for Ocular Diseases, Chongqing, P. R. China.

Purpose: The differential gene expression of neural precursor cell expressed developmentally downregulated 9 (NEDD9) in human trabecular meshwork (HTM) cells after dexamethasone (Dex) treatment was confirmed through gene expression profiling. However, the regulatory mechanism of NEDD9 expression in HTM cells remains unknown. In this study, we investigated NEDD9 expression in HTM cells and gained a better understanding of glucocorticoid-induced glaucoma (GIG) pathophysiology. Read More

View Article and Full-Text PDF

Home monitoring of glaucoma using a home tonometer and a novel virtual reality visual field device: acceptability and feasibility.

Ophthalmol Glaucoma 2022 May 13. Epub 2022 May 13.

New York University Langone Health Department of Ophthalmology; New York University Langone Health Department of Population Health. Electronic address:

Objective: Our aim is to assess acceptability and feasibility of iCare HOME (HT) and Virtual Field (VF) in the home monitoring of glaucoma.

Design: Prospective feasibility and acceptability study SUBJECTS: 20 patients (39 eyes) with primary open angle glaucoma, open-angle glaucoma, ocular hypertension, or suspected glaucoma METHODS: Patients were trained and instructed to bring two devices home for 1 week and use the HT 4 times/day for 4 days and the VF 3 times total.

Main Outcome Measures: For acceptability, we conducted satisfaction surveys and semi-structured qualitative interviews with thematic analysis. Read More

View Article and Full-Text PDF

Modeling the Effects of Disease, Drug Properties, and Material on Drug Transport From Intraocular Lenses.

Transl Vis Sci Technol 2022 May;11(5):14

Department of Chemical Engineering, Queen's University, Kingston, Ontario, Canada.

Purpose: Surgically implanted intraocular lenses (IOLs) may be used as drug-delivery devices, but their effectiveness is not well defined. Computational fluid dynamics models were developed to investigate the capability of IOLs to release drugs at therapeutic concentrations.

Methods: Models were generated using COMSOL Multiphysics. Read More

View Article and Full-Text PDF

The Effects of Mechanical Stretch on Integrins and Filopodial-Associated Proteins in Normal and Glaucomatous Trabecular Meshwork Cells.

Front Cell Dev Biol 2022 29;10:886706. Epub 2022 Apr 29.

Casey Eye Institute, Oregon Health & Science University, Portland, OR, United States.

The trabecular meshwork (TM) is the tissue responsible for regulating aqueous humor fluid egress from the anterior eye. If drainage is impaired, intraocular pressure (IOP) becomes elevated, which is a primary risk factor for primary open angle glaucoma. TM cells sense elevated IOP via changes in their biomechanical environment. Read More

View Article and Full-Text PDF

Multicenter, Prospective, Randomized, Single Blind, Cross-Over Study on the Effect of a Fixed Combination of Citicoline 500 mg Plus Homotaurine 50 mg on Pattern Electroretinogram (PERG) in Patients With Open Angle Glaucoma on Well Controlled Intraocular Pressure.

Front Med (Lausanne) 2022 29;9:882335. Epub 2022 Apr 29.

Department of Surgical Sciences, University Eye Clinic, Fondazione IRCCS Policlinico S. Matteo, Pavia, Italy.

Purpose: To evaluate the potential beneficial and synergistic effects of oral intake of a fixed combination of citicoline 500 mg plus homotaurine 50 mg (CIT/HOMO) on retinal ganglion cell (RGC) function in subjects with glaucoma using pattern electroretinogram (PERG) and to investigate the effects on visual field and quality of life.

Methods: Consecutive patients with primary open-angle glaucoma with controlled IOP (<18 mmHg) receiving beta-blockers and prostaglandin analogs alone or as combination therapy (fixed or un-fixed); with stable disease (progression no more than -1 dB/year at the visual field MD); and an early to moderate visual field defect (MD < -12 dB) were randomized to: arm A. topical therapy + CIT/HOMO for 4 months, 2 months of wash out, 4 months of topical therapy alone; arm B. Read More

View Article and Full-Text PDF

The analysis of the glaucoma screening event results obtained during the World Glaucoma Week in Zagreb, Croatia.

Int Ophthalmol 2022 May 14. Epub 2022 May 14.

University Department of Ophthalmology and Optometry, Sestre Milosrdnice University Hospital Center, Vinogradska 29, Zagreb, Croatia.

Purpose: To report the prevalence of undiagnosed glaucoma, as well as demographic characteristics and risk factors among glaucoma suspects who were detected in a publicly promoted intraocular pressure (IOP) based glaucoma screening event.

Methods: A total of 2468 subjects older than 18 years participated in the glaucoma screening event in Zagreb, in 2014, which included a medical interview and IOP measurement using Icare tonometer. 256 subjects (10. Read More

View Article and Full-Text PDF

Asian Race and Primary Open-Angle Glaucoma: Where Do We Stand?

J Clin Med 2022 Apr 28;11(9). Epub 2022 Apr 28.

Department of Ophthalmology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.

Primary open-angle glaucoma (POAG) is an optic neuropathy characterized by irreversible retinal ganglion cell damage and visual field loss. The global POAG prevalence is estimated to be 3.05%, and near term is expected to significantly rise, especially within aging Asian populations. Read More

View Article and Full-Text PDF

Attenuated Amplitude of Pattern Electroretinogram in Glaucoma Patients with Choroidal Parapapillary Microvasculature Dropout.

J Clin Med 2022 Apr 28;11(9). Epub 2022 Apr 28.

Department of Ophthalmology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea.

This study aims to investigate whether parapapillary choroidal microvasculature dropout (MvD) is related to visual function measured by pattern electroretinogram (PERG) in glaucomatous eyes with β-zone parapapillary atrophy (PPA). A total of 79 patients with open angle glaucoma and preperimetric glaucoma with β-zone PPA was included in this cross-sectional study. Through the deep layer of the Swept-source optical coherence tomography angiography image, the angular width and the area of MvD were measured. Read More

View Article and Full-Text PDF

Alterations in Fixation Indices in Primary Open-Angle Glaucoma by Microperimetry.

J Clin Med 2022 Apr 23;11(9). Epub 2022 Apr 23.

Department of Sensory Organ Studies, Collegium Medicum, Nicolaus Copernicus University, 85-830 Bydgoszcz, Poland.

The aim of this study was to determine whether primary open-angle glaucoma (POAG) is associated with changes in fixation stability parameters assessed by microperimetry (MP) and whether the severity of glaucoma is related to a deterioration in these indicators. This study analyzed fixation stability using MP macular analyzer integrity assessment (MAIA) in patients with mild and moderate/severe POAG and healthy controls. The resulting fixation indices were correlated with parameters used to assess retinal function with MP and standard automated perimetry (SAP) and retinal structure with optical coherence tomography (OCT) and OCT angiography (OCTA). Read More

View Article and Full-Text PDF

Factors associated with adherence to treatment in patients with open angle glaucoma in Sierra Leone, West Africa: patient demographics and questionnaire.

Int Ophthalmol 2022 May 13. Epub 2022 May 13.

Head of Eye Care Programme, Ministry of Health and Sanitation, Connaught Government Teaching Hospital, Freetown, Sierra Leone.

Background: Glaucoma is a significant cause of blindness worldwide. It is more common, presents earlier and is more aggressive in those of African descent. Non-adherence and poor knowledge of glaucoma is a significant barrier to treatment and has been associated with low health literacy. Read More

View Article and Full-Text PDF

Potentially Missed Opportunities in Prevention of Acute Angle-Closure Crisis.

JAMA Ophthalmol 2022 May 12. Epub 2022 May 12.

Department of Ophthalmology and Visual Sciences, University of Michigan Medical School, Ann Arbor.

Importance: If an anatomic narrow angle is not appropriately diagnosed and treated, it can result in acute angle-closure crisis (AACC) and lead to substantial vision loss.

Objective: To identify patients who presented with AACC and assess for factors that may have been associated with risk of developing it.

Design, Setting, And Participants: This population-based retrospective cohort study conducted from January 1, 2001, to December 31, 2015, included a 20% nationwide sample of 1179 Medicare beneficiaries. Read More

View Article and Full-Text PDF

Rates of Choroidal Microvasculature Dropout and Retinal Nerve Fiber Layer Changes in Glaucoma: Choroidal Dropout and Retinal Nerve Fiber Layer changes.

Am J Ophthalmol 2022 May 9. Epub 2022 May 9.

Hamilton Glaucoma Center, Shiley Eye Institute, Viterbi Family Department of Ophthalmology, University of California San Diego, La Jolla, California. Electronic address:

Purpose: To evaluate the association between rates of choroidal microvasculature dropout (MvD) change and rates of circumpapillary retinal nerve fiber layer (cpRNFL) loss in primary open-angle glaucoma (POAG) eyes.

Design: Cohort study from clinical trial data METHODS: A total of 91 eyes of 68 POAG patients with and without localized MvD at baseline with at least 4 visits and 2 years follow-up with optical coherence tomography angiography (OCT-A) and OCT scans were included. Area and angular circumference of MvD were evaluated on OCT-A en-face and B-scan choroidal vessel density images during the follow-up period. Read More

View Article and Full-Text PDF

The Causal Association Between Obesity and Primary Open-Angle Glaucoma: A Two-Sample Mendelian Randomization Study.

Front Genet 2022 25;13:835524. Epub 2022 Apr 25.

Department of Ophthalmology, The Third Affiliated Hospital of Chongqing Medical University, Chongqing, China.

The correlation between obesity and primary open-angle glaucoma (POAG) has not yet been fully established. The aim of this study was to investigate the causal relationship between obesity and POAG by a two-sample Mendelian randomization (MR) study. In this study, body mass index (BMI), an index to evaluate general obesity, and waist and hip circumference, indices to evaluate abdominal obesity, were selected as exposures in MR analysis. Read More

View Article and Full-Text PDF

Ex-PRESS® surgery versus trabeculectomy for primary open-angle glaucoma with low preoperative intraocular pressure.

Int Ophthalmol 2022 May 10. Epub 2022 May 10.

Department of Ophthalmology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, 2630 Sugitani, Toyama, 930-0194, Japan.

Purpose: To compare surgical outcomes between Ex-PRESS® surgery (EXP) and trabeculectomy (Trab) for primary open-angle glaucoma (POAG) with low preoperative intraocular pressure (IOP).

Patients And Methods: This was a retrospective non-randomized study. We included POAG patients with preoperative IOP ≤ 16 mmHg who were taking tolerance glaucoma medications. Read More

View Article and Full-Text PDF

Association between statin use and rates of structural and functional loss in glaucoma.

Br J Ophthalmol 2022 May 10. Epub 2022 May 10.

Department of Ophthalmology, Duke University, Durham, North Carolina, USA

Background/aims: To evaluate the association between statin use and rates of standard automated perimetry (SAP) and retinal nerve fibre layer (RNFL) change in patients with glaucoma and glaucoma suspects.

Methods: This retrospective cohort study included subjects from the Duke Glaucoma Registry with primary open-angle glaucoma and glaucoma suspects. Subjects were assigned to groups according to history of statin use. Read More

View Article and Full-Text PDF

Habitual coffee consumption increases risk of primary open-angle glaucoma: A Mendelian randomization study.

Ophthalmology 2022 May 7. Epub 2022 May 7.

Eye Hospital and School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou 325000, Zhejiang, China; National Clinical Research Center for Ocular Disease, Wenzhou, Zhejiang, China. Electronic address:

Purpose: To explore whether there is a causal relationship between coffee consumption and primary open-angle glaucoma (POAG).

Design: Two-sample Mendelian randomization.

Participants: The single-nucleotide polymorphisms (SNPs) associated with coffee consumption (including phenotype 1 and phenotype 2) were selected from a genome-wide association study (GWAS) involving 121,824 individuals of European descent. Read More

View Article and Full-Text PDF

MicroRNAs as biomarkers in glaucoma and potential therapeutic targets.

Neural Regen Res 2022 Nov;17(11):2368-2375

Department of Anatomy, University of Otago, Dunedin, New Zealand.

Glaucoma is a neurodegenerative disease in which optic nerve damage and visual field defects occur. It is a leading cause of irreversible blindness. Its pathogenesis is largely unknown although several risk factors have been identified, with an increase in intraocular pressure being the main one. Read More

View Article and Full-Text PDF
November 2022

Validation of the RCOphth and UKEGS glaucoma risk stratification tool 'GLAUC-STRAT-fast'.

Br J Ophthalmol 2022 May 9. Epub 2022 May 9.

Glaucoma Service, Moorfields Eye Hospital NHS Foundation Trust, London, UK

Background/aims: The aim of this study was to validate the Glaucoma Risk Stratification Tool (GLAUC-STRAT-fast) currently recommended by the Royal College of Ophthalmologists for the risk stratification of patients with glaucoma in the UK National Health Service Hospital Eye Service.

Methods: GLAUC-STRAT fast was applied to the LiGHT trial participants by risk-stratifying the worse eye of each patient at baseline and after 3 years of treatment. Metrics of disease severity or treatment intensity used for the validation were: increased number of monitoring visits or treatment escalations; needing a trabeculectomy; a reduction of >2 dB in visual field mean deviation (VF MD) during the monitoring period; identification of rapid VF loss on total (TD) and/or pattern deviation (PD). Read More

View Article and Full-Text PDF

Cost-Utility Analysis of STN1013001, a Latanoprost Cationic Emulsion, versus Other Latanoprost Formulations (Latanoprost) in Open-Angle Glaucoma or Ocular Hypertension and Ocular Surface Disease in France.

J Ophthalmol 2022 29;2022:3837471. Epub 2022 Apr 29.

Santen GmbH, München, Germany.

Purpose: To investigate the cost utility of STN1013001, a latanoprost cationic emulsion, versus Latanoprost in patients with open-angle glaucoma or ocular hypertension (OAG/OHT) and concomitant ocular surface disease (OSD) in France.

Methods: An early Markov model, including 7 health states and a 1-year cycle length, was developed to estimate the cost utility of STN1013001 versus Latanoprost from the French health system perspective over a 5-year time horizon. The model was populated with pooled data (treatment adherence, quality of life, disease progression, and resource utilization) collected, via a questionnaire, from a convenience sample of 5 French glaucoma specialists. Read More

View Article and Full-Text PDF

The Effect of Autonomic Nervous System Dysfunction on the Progression of Primary Open-Angle Glaucoma.

Int J Gen Med 2022 2;15:4565-4573. Epub 2022 May 2.

Department of Ophthalmology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, People's Republic of China.

Purpose: To study the effect of autonomic nervous system (ANS) dysfunction on glaucoma progression in patients with primary open angle glaucoma (POAG).

Patients And Methods: A retrospective study of 40 cases of POAG patients who underwent regular reexamination for more than 3 years was performed. All participants were subjected to heart-rate variability (HRV) assessment. Read More

View Article and Full-Text PDF