19,280 results match your criteria Glaucoma Pigmentary


Three-year effectiveness and safety of the XEN gel stent as a solo procedure or in combination with phacoemulsification in open-angle glaucoma: a multicentre study.

Acta Ophthalmol 2021 May 10. Epub 2021 May 10.

Department of Ophthalmology, University Hospitals UZ Leuven, Leuven, Belgium.

Purpose: To assess the 3-year effectiveness and safety of the XEN gel stent implanted ab interno in open-angle glaucoma (OAG).

Methods: This study was a multicentre, retrospective chart review of consecutive patients with OAG who underwent ab-interno gel stent placement alone or combined with phacoemulsification between 1 January 2014 and 1 October 2015. Outcome measures included mean changes in intraocular pressure (IOP) and IOP-lowering medication count from medicated baseline at 1, 2, 3 (primary outcome) and 4 years (if available) postimplantation. Read More

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Comparison of ganglion cell-inner plexiform layer thickness in exfoliative glaucoma and primary open-angle glaucoma.

Photodiagnosis Photodyn Ther 2021 May 7:102335. Epub 2021 May 7.

Department of Ophthalmology, Health Sciences University, Kayseri Training and Research Hospital, Kayseri, Turkey.

Purpose: To determine and compare the thickness of the ganglion cell-inner plexiform layer (GCIPL), the thickness of the retina nerve fiber layer (RNFL), and the parameters of the optic nerve head (ONH) in exfoliative glaucoma (XFG), primary open-angle glaucoma (POAG), and control eyes using optical coherence tomography (OCT).

Methods: The study was a retrospective observational cross-sectional study of 43 eyes of patients with XFG, 44 eyes of patients with POAG, and 37 eyes of healthy participants. Visual acuity, intraocular pressure, central corneal thickness, rim-area, disc-area, average cup/disc ratio, vertical cup/disc ratio, cup volume, average RNFL thickness, and GCIPL (average, minimum, superior, superotemporal, superonasal, inferior, inferotemporal, and inferonasal) thicknesses were determined. Read More

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Visual field-based grading of disease severity in newly diagnosed primary open angle glaucoma patients presenting to a tertiary eye care centre in India.

Int Ophthalmol 2021 May 9. Epub 2021 May 9.

Aravind Eye Hospital, Madurai, Tamil Nadu, India.

Purpose: To evaluate the severity of primary open angle glaucoma (POAG) at presentation using visual field analysis and its relationship to demographic and ocular factors in patients presenting to a tertiary eye care centre.

Design: Cross-sectional study.

Methods: Newly diagnosed POAG patients were classified as early, moderate, or severe stage in the worse eye based on the Humphrey visual field testing using Hodapp-Parrish-Andersons criteria. Read More

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Selective Laser Trabeculoplasty Versus MIGS: Forgotten Art or First-Step Procedure in Selected Patients with Open-Angle Glaucoma.

Ophthalmol Ther 2021 May 7. Epub 2021 May 7.

Department of Ophthalmology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Berlin Institute of Health, Humboldt-Universität Zu Berlin, Augustenburger Platz 1, 13353, Berlin, Germany.

Introduction: To evaluate the long-term effect on intraocular pressure (IOP) and glaucoma medication of selective laser trabeculoplasty (SLT) compared to minimally invasive glaucoma surgery (MIGS) in primary open-angle glaucoma (POAG) and its potential in clinical practice.

Methods: A total of 342 consecutive patients (stand-alone procedures) were included. One hundred and five patients underwent SLT treatment (360° SLT, 95-105 spots, Trabeculas SLT ARCLaser, Nürnberg, DE), 107 patients had an ab interno-derived trabeculotomy (Trabectome, NeoMedix, Tustin, USA), and 130 patients received iStent inject implantation (2 implants-Glaukos, CA, USA). Read More

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Elevated dimethylarginine, ATP, cytokines, metabolic remodeling involving tryptophan metabolism and potential microglial inflammation characterize primary open angle glaucoma.

Sci Rep 2021 May 7;11(1):9766. Epub 2021 May 7.

Disease Biology Lab, SSSIHL-Agilent Center for Excellence in Multiomics and Cell Sciences, Dept. of Biosciences, Sri Sathya Sai Institute of Higher Learning, Prasanthi Nilayam, Anantapur, Andhra Pradesh, 515 134, India.

Glaucoma of which primary open angle glaucoma (POAG) constitutes 75%, is the second leading cause of blindness. Elevated intra ocular pressure and Nitric oxide synthase (NOS) dysfunction are hallmarks of POAG. We analyzed clinical data, cytokine profile, ATP level, metabolomics and GEO datasets to identify features unique to POAG. Read More

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The Risks and Benefits of Myopia Control.

Ophthalmology 2021 May 4. Epub 2021 May 4.

Children's University Hospital, Dublin, Ireland; Technological University Dublin, Dublin, Ireland.

Objective: The prevalence of myopia is increasing around the world, stimulating interest in methods to slow its progression. The primary justification for slowing myopia progression is to reduce the risk of vision loss through sight-threatening ocular pathology in later life. The paper analyzes whether the potential benefits of slowing myopia progression by one diopter justify the potential risks associated with treatments. Read More

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Agonistic autoantibodies against ß2-adrenergic receptor influence retinal microcirculation in glaucoma suspects and patients.

PLoS One 2021 7;16(5):e0249202. Epub 2021 May 7.

Department of Ophthalmology, University of Erlangen-Nürnberg, Friedrich-Alexander-University of Erlangen-Nürnberg, Erlangen, Germany.

Purpose: Agonistic β2-adrenergic receptor autoantibodies (β2-agAAb) have been observed in sera of patients with ocular hypertension and open-angle glaucoma (OAG). They target the β2-receptors on trabecular meshwork, ciliary body and pericytes (Junemann et al. 2018; Hohberger et al. Read More

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Differences in the eyelid and buccal microbiome of glaucoma patients receiving long-term administration of prostaglandin analog drops.

Graefes Arch Clin Exp Ophthalmol 2021 May 7. Epub 2021 May 7.

Veterans Medical Research Institute, Veterans Health Service Medical Center , 05368, Jinhwangdo-ro 61-gil 53, Gangdong-gu, Seoul, Republic of Korea.

Purpose: To investigate the differences in the eyelid and buccal microbiomes between patients receiving long-term prostaglandin analogs for open-angle glaucoma (PG-OAG) and naïve-OAG patients by using metagenomics.

Methods: Eyelid and buccal samples were collected from 30 PG-OAG and 32 naïve-OAG patients. The taxonomic composition of the microbiome was obtained via 16S rRNA gene sequencing, operational taxonomic unit analysis, and diversity analysis. Read More

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Synergic effect of corneal hysteresis and central corneal thickness in the risk of early-stage primary open-angle glaucoma progression.

Graefes Arch Clin Exp Ophthalmol 2021 May 7. Epub 2021 May 7.

Laboratorio de Vision, Instituro de Tecnología del Conocimiento, Facultad de Psicología, Universidad Complutense de Madrid, Madrid, Spain.

Purpose: To evaluate corneal hysteresis (CH), acquired with ocular response analyzer (ORA), as a risk factor for glaucoma progression in early-stage primary open-angle glaucoma (POAG).

Methods: In a historical cohort study, patients diagnosed in 2011 with early-stage POAG according to the Hodapp, Parrish and Anderson classification modified for Octopus perimetry and followed up until glaucomatous progression development; otherwise, observations were censored in October 2018. Cox regression was used to obtain hazard ratios (HR) to evaluate baseline variables (CH, central corneal thickness, gender, age IOP and glaucoma family history) as risk factors for perimetric glaucoma progression. Read More

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Development of angle closure and associated risk factors: The Handan eye study.

Acta Ophthalmol 2021 May 7. Epub 2021 May 7.

Beijing Tongren Eye Center, Beijing Key Laboratory of Ophthalmology and Visual Science, Beijing Tongren Hospital, Capital Medical University, Beijing, China.

Purpose: To investigate the development of angle closure from baseline open angle and associated risk factors in a rural Chinese population through a longitudinal study over a 5-year period.

Methods: Subjects aged ≥30 years and older with bilateral open angles at baseline of the Handan Eye Study who participated in the follow-up and had undergone both baseline and follow-up gonioscopic examinations were included. Subjects with any form of angle closure, glaucoma, incisional ocular surgery or other conditions that could influence the results were excluded. Read More

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A Pedigree Report of a Rare Case of Weill-Marchesani Syndrome with New Compound Heterozygous LTBP2 Mutations.

Risk Manag Healthc Policy 2021 30;14:1785-1789. Epub 2021 Apr 30.

Department of Strabismus & Pediatric Ophthalmology, Shenzhen Eye Hospital Affiliated to Jinan University, The School of Optometry of Shenzhen University, Shenzhen, 518000, Guangdong Province, People's Republic of China.

Background: Weill-Marchesani syndrome (WMS) is an autosomal inherited connective tissue disease. Clinical manifestations include microspherophakia (MSP), high myopia, ectopia lentis, open-angle glaucoma, short stature, short fingers, joint stiffness, and (occasionally) cardiovascular defects. At present, a total of four pathogenic gene loci related to WMS have been found: ADAMTS10, ADAMTS17, FBN1, and LTBP2. Read More

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Implanted Microsensor Continuous IOP Telemetry Suggests Gaze and Eyelid Closure Effects on IOP-A Preliminary Study.

Invest Ophthalmol Vis Sci 2021 May;62(6)

Department of Ophthalmology, University Hospital Magdeburg, Germany.

Purpose: To explore the effect of gaze direction and eyelid closure on intraocular pressure (IOP).

Methods: Eleven patients with primary open-angle glaucoma previously implanted with a telemetric IOP sensor were instructed to view eight equally-spaced fixation targets each at three eccentricities (10°, 20°, and 25°). Nine patients also performed eyelid closure. Read More

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Metabolomics in Glaucoma: A Systematic Review.

Invest Ophthalmol Vis Sci 2021 May;62(6)

School of Public Health, Medical College of Soochow University, Suzhou, China.

Purpose: Glaucoma remains a poorly understood disease, and identifying biomarkers for early diagnosis is critical to reducing the risk of glaucoma-related visual impairment and blindness. The aim of this review is to provide current metabolic profiles for glaucoma through a summary and analysis of reported metabolites associated with glaucoma.

Methods: We searched PubMed and Web of Science for metabolomics studies of humans on glaucoma published before November 11, 2020. Read More

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The Hydrus Microstent in Pseudophakic Patients With Medically Refractory Open-angle Glaucoma.

J Glaucoma 2021 Feb;30(2):192-194

James Cook University College of Medicine and Dentistry, Douglas.

Purpose: Minimally invasive glaucoma surgery (MIGS) is an emerging therapy for glaucoma. The Hydrus Microstent is a MIGS device that stents Schlemm's canal, thereby increasing aqueous drainage and lowering intraocular pressure (IOP). This article describes the use of the microstent in pseudophakic patients with medically refractory glaucoma, a patient population undocumented in the current literature. Read More

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February 2021

Anterior Chamber Versus Ciliary Sulcus Ahmed Glaucoma Valve Tube Placement: Longitudinal Evaluation of Corneal Endothelial Cell Profiles.

J Glaucoma 2021 Feb;30(2):170-174

Department of Ophthalmology, Centro Hospitalar e Universitário São João.

Prcis: An Ahmed glaucoma valve (AGV) tube in the ciliary sulcus (CS) is safer for the endothelium. At 4 years of follow-up, there was a significant decrease in endothelial cell count only with anterior chamber (AC) placement.

Purpose: Corneal endothelium (CE) damage is one of the most feared long-term complications that can result from glaucoma drainage devices. Read More

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February 2021

Deep Sclerectomy With Intrascleral Versus Suprachoroidal Collagen Implant: A Randomized Control Trial.

J Glaucoma 2021 Feb;30(2):124-128

Geneva University Hospitals (HUG), University of Geneva, Geneva, Switzerland.

Prcis: Deep sclerectomy with intrascleral collagen implant (DSCI) was less effective in lowering intraocular pressure (IOP) than with suprachoroidal implantation. Further studies are needed to establish the potency and safety of deep sclerectomy with suprachoroidal collagen implant (DSSCI).

Purpose: The purpose of this study was to analyze the safety and IOP-lowering effect of DSSCI in comparison with DSCI. Read More

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February 2021

Yogic Pranayama and Diaphragmatic Breathing: Adjunct Therapy for Intraocular Pressure in Patients With Primary Open-angle Glaucoma: A Randomized Controlled Trial.

J Glaucoma 2021 Feb;30(2):115-123

Departments of Ophthalmology.

Prcis: Yogic pranayama and diaphragmatic breathing are potential adjunctive therapies for patients with glaucoma; however, they are not substitutes for medicine or eye drops.

Purpose: Currently, medical or surgical lowering of intraocular pressure is the only therapeutic approach for treating primary open-angle glaucoma. Intraocular pressure maintenance is influenced by autonomic activity (sympathetic and parasympathetic). Read More

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February 2021

Laser in Glaucoma and Ocular Hypertension Trial (LIGHT) in China A Randomized Controlled Trial: Design and Baseline Characteristics.

Am J Ophthalmol 2021 May 2. Epub 2021 May 2.

State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Centre, Sun Yat-sen University, Guangzhou, PRC. Electronic address:

Purpose: To describe the baseline characteristics of a trial to evaluate whether selective laser trabeculoplasty (SLT), as a first-line treatment, provides superior economic and health-related quality of life outcomes to medical treatment in China.

Design: LiGHT China trial is an unmasked, single-center, pragmatic, Randomized controlled trial.

Methods: 771 previously undiagnosed patients with primary open angle glaucoma (POAG, 622 patients) or ocular hypertension (OHT, 149 patients) at Zhongshan Ophthalmic Center were recruited from March 2015 to January 2019. Read More

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Unilateral Ocular Siderosis Bulbi Due to Missed Metallic Intraocular Foreign Body Masquerading as Anisocoria of Neurological Origin: A Case Report.

Am J Case Rep 2021 May 5;22:e930504. Epub 2021 May 5.

Department of Special Surgery, Division of Ophthalmology, Faculty of Medicine, Jordan University of Science and Technology, Irbid, Jordan.

BACKGROUND Ocular siderosis is an uncommon cause of vision loss due to a retained ferrous intraocular foreign bodies (IOFB) that cause iron deposition in ocular tissues. The most common manifestations are cataract formation, diffuse pigmentary changes of the retinal pigment epithelium, iris heterochromia, dilated pupils, secondary glaucoma, iritis, and cystoid macular edema. CASE REPORT We report a case of 38-year-old man who presented with a left dilated pupil and visual field defect. Read More

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Double versus single suture stenting to manage hypertensive spikes after glaucoma drainage device implantation.

Eur J Ophthalmol 2021 May 2:11206721211014386. Epub 2021 May 2.

Department of Neurosciences, Biomedicine and Movement, University Eye Clinic, University of Verona, AOUI - Borgo Roma Hospital, Verona, Veneto, Italy.

Purpose: To evaluate the safety and efficacy of double compared to single intraluminal suture stenting in reducing early postoperative hypertensive spikes (HS) and hypotony after Baerveldt glaucoma implant surgery.

Methods: For this retrospective study, we reviewed the medical charts of 60 patients (60 eyes) who underwent Baerveldt drainage device surgery between 2017 and 2019. Two groups were formed according to whether a single suture stent was placed within the tube (5-0 polypropylene, 30 eyes, group 1) or a double suture (5-0 and 6-0 polypropylene, 30 eyes, group 2). Read More

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Agreement between the newly developed OCT glaucoma staging system and the standardized visual field glaucoma staging system 2.

Eur J Ophthalmol 2021 May 2:11206721211014378. Epub 2021 May 2.

Department of Ophthalmology, Sohag Faculty of Medicine, Sohag University, Sohag, Egypt.

Purpose: The purpose of this research was to assess the agreement between the new optical coherence tomography (OCT) glaucoma staging system (GSS) and the visual field (VF) GSS 2 (GSS2).

Methods: This is a cross-sectional study of 161 eyes of 110 patients with controlled primary openangle glaucoma (POAG). All eyes were subjected to VF examination using standard automated perimetry and Humphrey field analyzer II 750. Read More

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Efficacy and safety data for the Ab interno XEN45 gel stent implant at 3 Years: A retrospective analysis.

Eur J Ophthalmol 2021 May 2:11206721211014381. Epub 2021 May 2.

Department of Ophthalmology, Mid and South Essex NHS Foundation Trust, Southend-on-Sea, UK.

Purpose: To report efficacy and safety measures of the XEN45 gel stent at 36 months in the UK National Health Service setting.

Methods: Retrospective non-comparative audit of the records of patients who underwent XEN45 implantation between June 2015 and May 2017 was performed. Main outcome measures were intraocular pressure and number of antihypertensive medications used. Read More

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Descemet stripping endothelial keratoplasty after cytomegalovirus corneal endotheliitis and immunosuppression for Mooren's ulcer.

Am J Ophthalmol Case Rep 2021 Jun 14;22:101088. Epub 2021 Apr 14.

Department of Ophthalmology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.

Purpose: The aim of this report was to describe a case of cataract surgery and Descemet stripping automated endothelial keratoplasty (DSAEK) after cytomegalovirus (CMV) corneal endotheliitis and bullous keratopathy (BK) following immunosuppressive treatment for Mooren's ulcer.

Observations: A 64-year-old man was referred to our hospital because of peripheral ulcerative keratitis in his left eye. He had a history of trabeculectomy for open angle glaucoma in his left eye. Read More

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Metabolomic Profiling of Aqueous Humor and Plasma in Primary Open Angle Glaucoma Patients Points Towards Novel Diagnostic and Therapeutic Strategy.

Front Pharmacol 2021 14;12:621146. Epub 2021 Apr 14.

Department of Ophthalmology and Visual Science, Eye and ENT Hospital, Shanghai Medical College, Fudan University, Shanghai, China.

Glaucoma is the second leading cause of blindness globally characterized by progressive loss of retinal ganglion cells (RGCs) and irreversible visual deficiency. As the most common type of glaucoma, primary open angle glaucoma (POAG) is currently an unmet medical need with limited therapy by lowering intraocular pressure (IOP). However, some patients continue to progress even though their IOP are controlled. Read More

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Ten-year-and-beyond longitudinal change of ß-zone parapapillary atrophy in glaucoma: association with retinal nerve fibre layer defect.

Br J Ophthalmol 2021 Apr 30. Epub 2021 Apr 30.

Department of Ophthalmology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Republic of Korea

Background: To investigate the longitudinal change of localised retinal nerve fibre layer (RNFL) defects associated with change of ß-zone parapapillary atrophy (PPA) in primary open-angle glaucoma (POAG) eyes.

Methods: POAG patients with a localised RNFL defect and ß-zone PPA who had undergone disc/RNFL photography at 1-year intervals for 10 years or longer were enrolled. The topographic parameters of ß-zone PPA (area, maximal radial extent and angular extent around disc) were measured. Read More

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Trabeculectomy with mitomycin C alone or coupled with intracamerular bevacizumab? A 2-year comparative study.

Br J Ophthalmol 2021 Apr 30. Epub 2021 Apr 30.

Ophthalmology, Centro Hospitalar Lisboa Norte, Lisboa, Portugal.

Purpose: To compare outcomes of primary trabeculectomy using either mitomycin C (MMC) alone versus MMC augmented with intracamerular bevacizumab in patients with open-angle glaucoma.

Methods: Retrospective, cohort, two-centre, comparative study. Patients' data were screened between October 2015 and March 2019, with inclusion requiring a minimum follow-up of 24 months. Read More

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Surgical Outcomes of Gonioscopy-Assisted Transluminal Trabeculotomy (GATT) in Patients with Open-Angle Glaucoma - A Retrospective Case Series.

Klin Monbl Augenheilkd 2021 Apr 30;238(4):391-395. Epub 2021 Apr 30.

Augenklinik, Luzerner Kantonsspital, Luzern, Switzerland.

Purpose: To evaluate the outcome of gonioscopy-assisted transluminal trabeculotomy (GATT) in patients with open-angle glaucoma (OAG).

Participants And Methods: A retrospective case series of patients with uncontrolled OAG treated by GATT at the cantonal Hospital Lucerne, a tertiary referral center, between October 2018 and July 2019 with a minimal 6-month follow-up period. Main outcome measures were intraocular pressure (IOP), number of antiglaucoma medications, and complications. Read More

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MicroRNAs in the aqueous humor of patients with different types of glaucoma.

Graefes Arch Clin Exp Ophthalmol 2021 Apr 30. Epub 2021 Apr 30.

Department of Diagnostics and Microsurgery of Glaucoma, Medical University of Lublin, ul. Chmielna 1, 20-079, Lublin, Poland.

Purpose: The aim of the study was to compare the frequency and the level of expression of selected miRNAs in the aqueous humor of patients with various types of glaucoma.

Methods: The studied group consisted of 42 patients with glaucoma: 19 with primary open-angle glaucoma (POAG), 14 with pseudoexfoliation glaucoma (PEXG), 9 with primary angle closure glaucoma (PACG), and the control group of 36 patients with senile cataract without glaucoma. The real-time polymerase chain reaction method was used to analyze the expression of miRNAs. Read More

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Evaluation of peripapillary atrophy in early open-angle glaucoma using autofluorescence combined with optical coherence tomography.

Int Ophthalmol 2021 Apr 29. Epub 2021 Apr 29.

Department of Ophthalmology, Faculty of Medicine, Kasr Al Ainy School of Medicine, Cairo University, Cairo, Egypt.

Purpose: To quantitatively analyze α-zone and β-zone peripapillary atrophy (PPA) in patients having early primary open-angle glaucoma (POAG) using fundus autofluorescence (FAF) in conjunction with spectral domain optical coherence tomography, colored photography and perimetry.

Design: This is an observational cross-sectional case-control study.

Methods: This study included 100 eyes (54 patients) of early to moderate POAG and 100 normal eyes (50 subjects). Read More

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Abnormal corneal properties in osteogenesis imperfecta and glaucoma: a case series.

BMJ Open Ophthalmol 2021 15;6(1):e000684. Epub 2021 Apr 15.

Ophthalmology, Mater Misericordiae University Hospital, Dublin, Ireland.

Objective: We aimed to carry out ocular examination and genetic studies in a family in which some members are affected with osteogenesis imperfecta (OI) and primary open-angle glaucoma (POAG). We compared the corneal properties of affected and unaffected members (ie, cases and controls).

Methods: Eight family members from two generations, both affected and unaffected, were examined. Read More

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