17,053 results match your criteria Glaucoma Pigmentary


Predictive Factors for the Rate of Visual Field Progression in the Advanced Imaging for Glaucoma Study.

Am J Ophthalmol 2019 Feb 19. Epub 2019 Feb 19.

Casey Eye Institute, Oregon Health & Science University. Electronic address:

Purpose: To investigate predictive factors associated with the rate of visual field (VF) loss in open-angle glaucoma.

Design: Prospective multicenter cohort study.

Methods: Perimetric glaucoma patients of the Advanced Imaging for Glaucoma study were selected for analysis if they had 9 completed visits. Read More

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http://dx.doi.org/10.1016/j.ajo.2019.02.015DOI Listing
February 2019

Transient ciliochoroidal detachment after 360-degree suture trabeculotomy ab interno for open-angle glaucoma: 12-month follow-up.

Eye (Lond) 2019 Feb 21. Epub 2019 Feb 21.

Hayashi Eye Hospital, 4-23-35 Hakataekimae, Hakata-ku, Fukuoka, 812-0011, Japan.

Objectives: To investigate the effects of ciliochoroidal detachment (CCD) after 360-degree suture trabeculotomy ab interno (360S-LOT ab interno) on intraocular pressure (IOP) and postoperative complications during a 12-month follow-up.

Methods: We prospectively examined 44 eyes of 44 patients for 12 months after 360S-LOT ab interno surgery. Inclusion criteria were open-angle glaucoma including primary open-angle glaucoma, normal tension glaucoma, and exfoliation glaucoma without previous glaucoma surgeries. Read More

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http://dx.doi.org/10.1038/s41433-019-0375-5DOI Listing
February 2019

Enhancement of Retinal Function and of Neural Conduction Along the Visual Pathway Induced by Treatment with Citicoline Eye Drops in Liposomal Formulation in Open Angle Glaucoma: A Pilot Electrofunctional Study.

Adv Ther 2019 Feb 21. Epub 2019 Feb 21.

DSCMT, University of Rome Tor Vergata, Rome, Italy.

Introduction: To evaluate the retinal function and the relative neural conduction along the visual pathway after treatment with citicoline in liposomal formulation (CLF) eye drops in patients with open angle glaucoma (OAG).

Methods: Twelve OAG patients (mean age ± standard deviation 52.58 ± 11. Read More

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http://dx.doi.org/10.1007/s12325-019-0897-zDOI Listing
February 2019

Effect of Scan Size on Glaucoma Diagnostic Performance using OCT Angiography En Face Images of the Radial Peripapillary Capillaries.

J Glaucoma 2019 Feb 15. Epub 2019 Feb 15.

USC Roski Eye Institute, Keck Medicine of University of Southern California, 1450 San Pablo St, Suite 4700, Los Angeles, CA 90033, United States.

Precis: When comparing 4.5×4.5▒mm to 6. Read More

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http://dx.doi.org/10.1097/IJG.0000000000001216DOI Listing
February 2019

Different Disc Characteristics Associated With High Myopia and the Location of Glaucomatous Damage in Primary Open-Angle Glaucoma and Normal-Tension Glaucoma.

J Glaucoma 2019 Feb 15. Epub 2019 Feb 15.

Department of Ophthalmology, MacKay Memorial Hospital, Taipei, Taiwan.

PRéCIS:: Disc tilt is a characteristic of high myopia and related to lower wedge-shaped RNFL defects in NTG. In POAG, the direction of disc torsion corresponds to the location of wedge-shaped RNFL defects.

Purpose: To evaluate the disc characteristics in high myopia and the relationships between disc tilt and torsion and the location of wedge-shaped retinal nerve fiber layer (RNFL) defects in primary open-angle glaucoma (POAG) and normal-tension glaucoma (NTG). Read More

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http://dx.doi.org/10.1097/IJG.0000000000001217DOI Listing
February 2019

Screening of Arg368His as predominant mutation in North Indian primary open angle glaucoma and juvenile onset glaucoma patients.

Mol Biol Res Commun 2018 Dec;7(4):181-186

Department of Human Genetics, Guru Nanak Dev University, Amritsar 143005, India.

In India, mutations in Cytochrome P450 () are a predominant cause of not only primary congenital glaucoma (PCG) but also involved in primary open angle glaucoma (POAG) and juvenile onset glaucoma (JOAG). After ethical clearance, 100 POAG patients, 30 primary angle closure glaucoma (PACG) patients and 130 ethnically matched controls were recruited in this study. Genomic DNA was isolated from the blood and screened for p. Read More

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http://dx.doi.org/10.22099/mbrc.2018.30630.1344DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363938PMC
December 2018

Effect of Phacoemulsification on Intraocular Pressure in Healthy Subjects and Glaucoma Patients.

J Korean Med Sci 2019 Feb 30;34(6):e47. Epub 2019 Jan 30.

Department of Ophthalmology, Hallym University Dongtan Sacred Heart Hospital, Hallym University College of Medicine, Hwaseong, Korea.

Background: We investigated how cataract surgery might influence long-term intraocular pressure (IOP) change in both healthy subjects and glaucoma patients.

Methods: A retrospective analysis of patients who had had clear corneal phacoemulsification with a minimum of 12 months of follow up was performed. Glaucoma patients with medically controlled open-angle glaucoma and healthy subjects with no glaucoma were included in the analysis. Read More

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http://dx.doi.org/10.3346/jkms.2019.34.e47DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374551PMC
February 2019

Effects of Trabeculectomy on Waveform Changes of Laser Speckle Flowgraphy in Open Angle Glaucoma.

Invest Ophthalmol Vis Sci 2019 Feb;60(2):677-684

Department of Ophthalmology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan.

Purpose: To investigate the effect of trabeculectomy on the waveform changes of laser speckle flowgraphy (LSFG) in the optic nerve head (ONH) in patients with glaucoma.

Methods: Forty-eight eyes of 48 patients with open angle glaucoma were included in this prospective study. LSFG was performed before and 1, 3, and 6 months after trabeculectomy. Read More

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http://dx.doi.org/10.1167/iovs.18-25694DOI Listing
February 2019

Ocular dialysis disequilibrium-Management of intraocular pressure during hemodialysis of open angle glaucoma: A case report and review of the literature.

Hemodial Int 2019 Feb 20. Epub 2019 Feb 20.

Division of Nephrology, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA.

It has been shown that patients with end-stage renal disease (ESRD) have an increased risk for changes in intraocular pressure during hemodialysis, or ocular dialysis disequilibrium which can cause pain or discomfort during treatment and lead to decreased vision over time. This is a case of an elderly male with ESRD who was having headaches, nausea, and eye pain during hemodialysis due to increased intraocular pressures. Using a higher sodium prescription resolved his symptoms and normalized his intraocular pressures. Read More

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http://dx.doi.org/10.1111/hdi.12718DOI Listing
February 2019

Diagnostic utility of central damage determination in glaucoma by magnetic resonance imaging: An observational study.

Exp Ther Med 2019 Mar 24;17(3):1891-1895. Epub 2018 Dec 24.

Department of Ophthalmology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, P.R. China.

The aim of the present study was to investigate the utility of diffusion tensor imaging (DTI) parameters of the central visual pathway and the size of the lateral geniculate nucleus (LGN) in the diagnosis of primary open-angle glaucoma (POAG). To test this, 24 POAG patients and 24 age- and gender-matched controls underwent 3.0 Tesla magnetic resonance imaging examinations, including DTI and LGN structural imaging. Read More

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http://dx.doi.org/10.3892/etm.2018.7134DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364226PMC

Measurement of Structural Parameters of the Lamina Cribrosa in Primary Open-Angle Glaucoma and Chronic Primary Angle-Closure Glaucoma by Optical Coherence Tomography and Its Correlations with Ocular Parameters.

Ophthalmic Res 2019 Feb 15:1-10. Epub 2019 Feb 15.

State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou,

Purpose: To measure lamina cribrosa thickness (LCT) and anterior lamina cribrosa surface depth (ALCSD) in primary open-angle glaucoma (POAG), chronic primary angle-closure glaucoma (CPACG), and control patients using spectral-domain optical coherence tomography (SD-OCT) and examine its association with relevant ocular parameters.

Methods: In this cross-sectional study, 61 healthy volunteers (61 eyes), 65 POAG patients (65 eyes), and 55 CPACG patients (55 eyes) were recruited to obtain radial B-scans of the optic nerve head by way of enhanced depth imaging using Heidelberg SD-OCT. The obtained LCT and ALCSD were compared among the control, POAG, and CPACG groups. Read More

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http://dx.doi.org/10.1159/000496558DOI Listing
February 2019

Comprehensive measurements of hydroxylinoleate and hydroxyarachidonate isomers in blood samples from primary open-angle glaucoma patients and controls.

Sci Rep 2019 Feb 18;9(1):2171. Epub 2019 Feb 18.

Health Research Institute, National Institute of Advanced Industrial Science and Technology, 2217-14 Hayashicho, Takamatsu, Kagawa, 761-0395, Japan.

We previously reported that lower systemic antioxidant capacity is involved in primary open-angle glaucoma (POAG) and exfoliation syndrome pathogeneses as measured by ferric-reducing activity. In the present study, we measured hydroxylinoleate (HODE) and hydroxyarachidonate (HETE) isomer serum levels after sample reduction and saponification to investigate POAG pathogenesis. POAG patients (n = 198) were recruited and divided into normal- and high-tension glaucoma groups (n = 84 and 114, respectively) depending on intraocular pressure. Read More

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http://dx.doi.org/10.1038/s41598-018-36952-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6379359PMC
February 2019

Profile of childhood glaucoma at a tertiary center in South India.

Indian J Ophthalmol 2019 Mar;67(3):358-365

VST Glaucoma Center, L V Prasad Eye Institute, Banjara Hills, Hyderabad, Telangana, India.

Purpose: To describe the prevalence of various types of childhood glaucomas, their clinical features and treatment methods.

Methods: We prospectively included consecutive children with glaucoma presenting to glaucoma clinic for the first time between March 2013 and May 2014. We classified childhood glaucomas as per the classification proposed by Congenital Glaucoma Research Network. Read More

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http://dx.doi.org/10.4103/ijo.IJO_786_18DOI Listing

Effect of systemic antihypertensives on change in intraocular pressure after initiating topical prostaglandins for primary open-angle glaucoma.

Clin Ophthalmol 2019 23;13:207-213. Epub 2019 Jan 23.

Medical Center Ophthalmology Associates, San Antonio, TX, USA,

Purpose: There is a limited understanding of factors that influence the efficacy of topical glaucoma medication. Our study is a long-term, case-control analysis of how systemic antihypertensive (anti-HTN) medications influence the change in IOP after initiating prostaglandin (PG) drop therapy.

Materials And Methods: A retrospective chart review of 3,781 patients was performed on patients with a diagnosis of glaucoma suspect that progressed to primary open-angle glaucoma (POAG) by ICD-9 codes over a 10-year period. Read More

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http://dx.doi.org/10.2147/OPTH.S192010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350645PMC
January 2019
1 Read

Penetrating deep sclerectomy in primary open-angle and pseudoexfoliative glaucoma.

Eur J Ophthalmol 2019 Feb 17:1120672119827768. Epub 2019 Feb 17.

2 Eye Institute of Thrace, Democritus University of Thrace, Alexandroupolis, Greece.

Purpose:: To evaluate the outcomes of a new antiglaucoma surgical method, a modification of the standard deep sclerectomy, the penetrating deep sclerectomy.

Participants:: Patients with medically uncontrolled primary open-angle glaucoma or pseudoexfoliative glaucoma were prospectively, in a consecutive way, enrolled in this study.

Methods:: The study was conducted in Glaucoma Unit, Department of Ophthalmology, University of Hospital of Alexandroupolis, Greece, in 29 eyes of 29 patients. Read More

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http://dx.doi.org/10.1177/1120672119827768DOI Listing
February 2019

"Intraocular Oxygen and Antioxidant Status: New Insights on the Effect of Vitrectomy and Glaucoma Pathogenesis".

Am J Ophthalmol 2019 Feb 14. Epub 2019 Feb 14.

Department of Ophthalmology and Visual Sciences Washington University School of Medicine, St. Louis, Missouri.

Purpose: To investigate correlations of oxygen (pO) in the ocular anterior segment of human eyes and aqueous humor antioxidant levels of ascorbate (AsA) and total reactive antioxidant potential (TRAP) with glaucoma and vitreous status.

Methods: This prospective, cross-sectional study stratified patients (n=288 eyes) by lens and vitreous status and presence of primary open angle glaucoma for statistical analyses. Intraocular pO measurements with a fiberoptic probe were made in patients at the beginning of planned glaucoma and/or cataract surgery. Read More

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http://dx.doi.org/10.1016/j.ajo.2019.02.008DOI Listing
February 2019

Fluctuations of the intraocular pressure in medically versus surgically treated glaucoma patients by a contact lens sensor.

Am J Ophthalmol 2019 Feb 13. Epub 2019 Feb 13.

Translational Research in Respiratory Medicine; Arnau de Vilanova-Santa María University Hospital; IRBLleida, Catalonia, Spain.

Purpose: To compare fluctuations in intraocular pressure (IOP) in medically versus surgically treated glaucoma patients.

Design: Prospective, non-randomized case series.

Methods: IOP-related fluctuations were measured for 24 hours using a contact lens sensor (CLS). Read More

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http://dx.doi.org/10.1016/j.ajo.2019.02.003DOI Listing
February 2019
1 Read

Effective treatment of refractory sympathetic ophthalmia with glaucoma using adalimumab.

Am J Ophthalmol Case Rep 2019 Jun 25;14:1-4. Epub 2019 Jan 25.

Department of Ophthalmology and Visual Science, Graduate School of Biomedical Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima City, Hiroshima, 734-8551, Japan.

Purpose: Sympathetic ophthalmia (SO) is an autoimmune, bilateral, granulomatous panuveitis, which occurs following penetrating eye injury or eye surgery. We report two cases of refractory SO in patients with a history of trabeculectomy, which were treated effectively with adalimumab.

Observations: Case 1: A 69-year-old male with a history of trabeculectomy for rubeotic glaucoma of the right eye, secondary to diabetic retinopathy 8 years prior, presented with a decrease in visual acuity of the left eye due to SO. Read More

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http://dx.doi.org/10.1016/j.ajoc.2019.01.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360245PMC
June 2019
1 Read

Early Macular Angiography among Patients with Glaucoma, Ocular Hypertension, and Normal Subjects.

J Ophthalmol 2019 15;2019:7419470. Epub 2019 Jan 15.

Department of Ophthalmology, Show Chwan Memorial Hospital, Changhua, Taiwan.

Purpose: To evaluate early macular circulation in open-angle glaucoma (OAG), normal-tension glaucoma (NTG), ocular hypertension (OHT), and healthy subjects via optical coherence tomography angiography (OCTA).

Methods: A retrospective cross-sectional study was conducted. Medical records were reviewed, and the patients who received OCTA examinations were divided into the OAG, NTG, OHT, and normal groups. Read More

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http://dx.doi.org/10.1155/2019/7419470DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350555PMC
January 2019
1 Read

The Association of Oxidative Stress Status with Open-Angle Glaucoma and Exfoliation Glaucoma: A Systematic Review and Meta-Analysis.

J Ophthalmol 2019 15;2019:1803619. Epub 2019 Jan 15.

Department of Clinical Laboratory, Eye & ENT Hospital, Shanghai Medical College, Fudan University, Shanghai, China.

Purpose: To systematically evaluate the associations between oxidative stress status and different types of glaucoma.

Design: Systematic review and meta-analysis.

Methods: We searched PubMed, EMBASE, and the Web of Science for randomized controlled trials written in the English language between January 1, 1990, and November 30, 2016. Read More

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http://dx.doi.org/10.1155/2019/1803619DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350588PMC
January 2019

[Neuronal Blood Pressure Regulation].

Klin Monbl Augenheilkd 2019 Feb 14;236(2):145-149. Epub 2019 Feb 14.

Institut für Kreislaufforschung und Sportmedizin, Deutsche Sporthochschule Köln.

Neuronal blood pressure control is mediated by the autonomic nervous system. In this article, physiological and pathophysiological mechanisms will be recapitulated. Blood pressure regulation aims at maintaining adequate cardiac output and a sufficient perfusion pressure for the organs. Read More

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http://dx.doi.org/10.1055/a-0808-4843DOI Listing
February 2019

[The Importance of the Lymphatic and the Glymphatic System for Glaucoma].

Klin Monbl Augenheilkd 2019 Feb 14;236(2):142-144. Epub 2019 Feb 14.

Augenklinik, Kantonsspital Aarau, Schweiz.

Normal tension glaucoma is a variant of primary open angle glaucoma. It is characterized by normal intraocular pressure. Although there are several pathophysiological explanations (e. Read More

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http://dx.doi.org/10.1055/a-0809-5692DOI Listing
February 2019

The genetic influence on corticosteroid-induced ocular hypertension: A field positioned for discovery.

Am J Ophthalmol 2019 Feb 11. Epub 2019 Feb 11.

Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, 243 Charles Street, Boston, MA 02114. Electronic address:

Purpose: To provide evidence that corticosteroid-induced ocular hypertension has a genetic component.

Design: Evidence-based Perspective.

Methods: We conducted a comprehensive literature search for studies exploring genetic influences on intraocular pressure responses to corticosteroid treatment. Read More

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http://dx.doi.org/10.1016/j.ajo.2019.02.001DOI Listing
February 2019
1 Read

Migraine and increased risk of developing open angle glaucoma: a population-based cohort study.

BMC Ophthalmol 2019 Feb 13;19(1):50. Epub 2019 Feb 13.

Department of Ophthalmology, National Taiwan University Hospital, Hsin-Chu Branch, Hsin-Chu, Taiwan.

Background: Migraine is linked to endothelial dysfunction and is considered to be a systemic vasculopathy. Interestingly, systemic vascular diseases also occur in glaucoma patients and are considered to be vascular risk factors. Whether migraine is simply a concomitant condition in glaucoma patients or a risk factor per se for glaucoma remains unknown. Read More

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http://dx.doi.org/10.1186/s12886-019-1062-9DOI Listing
February 2019

Two-year results of a multicenter study of the ab interno gelatin implant in medically uncontrolled primary open-angle glaucoma.

Graefes Arch Clin Exp Ophthalmol 2019 Feb 13. Epub 2019 Feb 13.

Department of Ophthalmology, University Hospitals UZ Leuven, Leuven, Belgium.

Purpose: To evaluate the effectiveness of an ab interno subconjunctival gelatin implant as primary surgical intervention in reducing intraocular pressure (IOP) and IOP-lowering medication count in medically uncontrolled moderate primary open-angle glaucoma (POAG).

Methods: In this prospective, non-randomized, open-label, multicenter, 2-year study, eyes with medicated baseline IOP 18-33 mmHg on 1-4 topical medications were implanted with (phaco + implant) or without (implant alone) phacoemulsification. Changes in mean IOP and medication count at months 12 (primary outcomes) and 24, clinical success rate (eyes [%] achieving ≥ 20% IOP reduction from baseline on the same or fewer medications without glaucoma-related secondary surgical intervention), intraoperative complications, and postoperative adverse events were assessed. Read More

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http://dx.doi.org/10.1007/s00417-019-04251-zDOI Listing
February 2019

Evaluation of Antiglaucomatous Drops on Conjunctival Thickness in Patients with Primary Open-Angle Glaucoma.

J Ocul Pharmacol Ther 2019 Feb 13. Epub 2019 Feb 13.

Department of Ophthalmology, Faculty of Medicine, Yuzuncu Yil University, Van, Turkey.

Purpose: To determine the effects of antiglaucomatous drops on the conjunctival thickness.

Methods: Between March 2018 and May 2018, conjunctival thicknesses (epithelium + stroma) were measured with anterior segment OCT in 51 eyes of the control group and 49 eyes who had glaucoma diagnosis at the Van YYU Medical Faculty Ophthalmology Department and had been using antiglaucomatous drops for at least 6 months. At 12 o'clock direction, horizontal multisections were taken aiming at the conjunctiva 3-5 mm away from the limbus. Read More

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http://dx.doi.org/10.1089/jop.2018.0124DOI Listing
February 2019

Absence of Posterior Vitreous Detachment Is a Risk Factor of Severe Bleb-Related Endophthalmitis.

J Ophthalmol 2019 14;2019:1585830. Epub 2019 Jan 14.

Department of Ophthalmology, Tokyo Medical University, Tokyo, Japan.

Purpose: Bleb-related endophthalmitis (BRE) after glaucoma surgery is an infection caused by bacteria in the avascular bleb gaining access into the eye. We report the clinical features and outcome of 10 consecutive eyes with severe BRE treated at our hospital.

Methods: Ten patients (10 eyes) with stage IIIb BRE after trabeculectomy diagnosed and treated at the Department of Ophthalmology, Tokyo Medical University, between April 2013 and May 2015, were studied. Read More

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http://dx.doi.org/10.1155/2019/1585830DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348893PMC
January 2019

Anterior Chamber Angle, Volume, and Depth in a Normative Cohort-A Retrospective Cross-Sectional Study.

Curr Eye Res 2019 Feb 12:1-6. Epub 2019 Feb 12.

a Department of Ophthalmology , Goethe-University , Frankfurt , Germany.

Purpose: The purpose of the study was to determine the distribution of the anterior chamber angle (ACA) within a population-based study sample in Germany and to find correlations between age, sphere, and biometric parameters of the anterior chamber.

Patients And Methods: A total of 500 eyes, approximately 100 eyes per decade starting with patient age of 20 years, of 463 patients with an average age of 45.2 ± 14. Read More

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https://www.tandfonline.com/doi/full/10.1080/02713683.2019.1
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http://dx.doi.org/10.1080/02713683.2019.1576205DOI Listing
February 2019
3 Reads

Transient visual field impairment after cold provocation in glaucoma patients with Flammer syndrome.

Restor Neurol Neurosci 2019 Feb 5. Epub 2019 Feb 5.

Department of Ophthalmology, University of Basel, Basel, Switzerland.

Background: It is still debatable whether visual field defects in glaucoma have a reversible component and to what extent a temporary loss can be provoked.

Objective: To investigate the response of the visual function to a cold provocation in glaucoma patients, particularly to test whether subjects with Flammer syndrome (FS) behaved differently from subjects without FS.

Methods: Ten (10) primary open-angle glaucoma (POAG) patients with FS, 7 POAG patients without FS, and 11 healthy controls were tested with program G2 on the Octopus 101 perimeter before and after putting one hand in cold water (4°C) for 2 min. Read More

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https://www.medra.org/servlet/aliasResolver?alias=iospress&a
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http://dx.doi.org/10.3233/RNN-180866DOI Listing
February 2019
3 Reads

Long-term follow-up of intraocular pressure and pressure-lowering medication in patients after ab-interno trabeculectomy with the Trabectome.

Graefes Arch Clin Exp Ophthalmol 2019 Feb 9. Epub 2019 Feb 9.

Eye Center, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany.

Background: The minimally invasive ab-interno trabeculectomy (AIT) via electro-ablation with the Trabectome has been on the European market since 2009. Many studies have proven the safety and efficacy of the procedure. Up until now, studies investigating the long-term effect of AIT have been sparse. Read More

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http://dx.doi.org/10.1007/s00417-019-04259-5DOI Listing
February 2019

Ciliochoroidal detachment after Ahmed glaucoma valve implantation: a retrospective study.

BMC Ophthalmol 2019 Feb 6;19(1):46. Epub 2019 Feb 6.

Affiliated Eye Hospital, School of Ophthalmology and Optometry, Wenzhou Medical University, Zhejiang, China.

Background: To investigate the occurrence of ciliochoroidal detachment (CCD), its risk factors and its impact on the success rate after Ahmed glaucoma valve (AGV) implantation.

Methods: This is a retrospective observational study carried out at Eye Hospital of Wenzhou Medical University, Zhejiang, China. Patients with uncontrolled glaucoma who underwent AGV implantation alone or combined with phacoemulsification (AGV-Phaco) in the hospital from April 1, 2013 to July 31, 2016 were included. Read More

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http://dx.doi.org/10.1186/s12886-019-1060-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368733PMC
February 2019
2 Reads
1.075 Impact Factor

[Analysis of Glaucomatous Changes of the Macula Using Optical Coherence Tomography].

Klin Monbl Augenheilkd 2019 Feb 8. Epub 2019 Feb 8.

IMISE, Institut für Medizinische Informatik, Statistik und Epidemiologie, Leipzig.

Background: In glaucoma, progressive retinal nerve fibre loss can be measured in the peripapillary and macular regions using optical coherence tomography (OCT). The goal of this study was to evaluate the impact of glaucoma on all measureable retinal layers using the spectral domain OCT (SD-OCT).

Materials And Methods: SD-OCT scans using automated retinal layer segmentation were performed in both eyes of primary open-angle glaucoma patients with strictly monocular absolute visual field scotoma in the central 10° of their visual field. Read More

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http://dx.doi.org/10.1055/a-0808-4807DOI Listing
February 2019

Increased prelaminar tissue thickness in patients with open-angle glaucoma and type 2 diabetes.

PLoS One 2019 7;14(2):e0211641. Epub 2019 Feb 7.

Department of Ophthalmology and Visual Science, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.

Background: The characteristics of the optic nerve head (ONH) in open angle glaucoma (OAG) patients with diabetes have not been reported. This study aimed to characterize the ONH structures and glaucomatous damage in diabetic OAG patients, using age-matched non-diabetic OAG patients and control subjects.

Methods: The locations of visual field defects of OAG patients were classified and the prelaminar thickness and lamina cribrosa depth were measured in 64 OAG patients with type 2 diabetes (OAG+DM), 68 OAG patients without diabetes (OAG-DM), and 36 controls. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0211641PLOS
February 2019

Association Between Lamina Cribrosa Defects and Progressive Retinal Nerve Fiber Layer Loss in Glaucoma.

JAMA Ophthalmol 2019 Feb 7. Epub 2019 Feb 7.

Hamilton Glaucoma Center, Shiley Eye Institute, Viterbi Family Department of Ophthalmology, University of California, San Diego.

Importance: Certain features of the lamina cribrosa may be associated with increased risk of glaucoma progression.

Objectives: To compare the rates of retinal nerve fiber layer (RNFL) thinning in patients with open-angle glaucoma with or without lamina cribrosa (LC) defects and to evaluate factors associated with the rate of glaucoma progression in eyes with LC defects.

Design, Setting, And Participants: This longitudinal cohort study designed in September 2017 and conducted at a tertiary glaucoma center in California included 51 eyes of 43 patients with LC defects and 83 eyes of 68 patients without LC defects followed up for a mean (SD) of 3. Read More

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http://archopht.jamanetwork.com/article.aspx?doi=10.1001/jam
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http://dx.doi.org/10.1001/jamaophthalmol.2018.6941DOI Listing
February 2019
3 Reads

Polymorphism rs7961953 in TMTC2 gene is not associated with primary open-angle glaucoma in a Saudi cohort.

Ophthalmic Genet 2019 Feb 7:1-3. Epub 2019 Feb 7.

a Department of Ophthalmology, Glaucoma Research Chair, College of Medicine , King Saud University , Riyadh , Saudi Arabia.

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http://dx.doi.org/10.1080/13816810.2019.1576210DOI Listing
February 2019
1 Read
1.233 Impact Factor

Lattice corneal dystrophy with familial amyloid polyneuropathy.

Int J Clin Pract 2019 Feb 6:e13320. Epub 2019 Feb 6.

Department of Ophthalmology, Osaka University Graduate School of Medicine, Osaka, Japan.

A 77-year-old Japanese female diagnosed with familial amyloid polyneuropathy type IV (FAP-IV) was referred for an ophthalmologic evaluation. Her general appearance showed a mask-like face because of facial nerve paralysis (Figure 1) and she exhibited tongue atrophy caused by hypoglossal nerve palsy (Figure 2). Corrected distance visual acuity was 6/9. Read More

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http://dx.doi.org/10.1111/ijcp.13320DOI Listing
February 2019

Combined phacoemulsification and viscocanalostomy with Ologen implant versus combined phacoemulsification and viscocanalostomy.

BMC Ophthalmol 2019 Feb 6;19(1):45. Epub 2019 Feb 6.

Ophthalmology Department, Zagazig University, Zagazig, 44511, Egypt.

Background: To study the efficacy of the biodegradable collagen implant Ologen® as an adjuvant in phaco-viscocanalostomy in patients with coexisting cataract and primary open angle glaucoma.

Methods: This prospective, interventional, randomized clinical study was done at Alpha Vision Center, Zagazig, Egypt. Patients with coexisting cataract and glaucoma were randomized to receive either phaco-viscocanalostomy (Phacovisco group) (39 eyes) or phaco-viscocanalostomy with Ologen® implant (OloPhacovisco group) (40 eyes). Read More

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http://dx.doi.org/10.1186/s12886-019-1049-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364460PMC
February 2019
1 Read
1.075 Impact Factor

Analysis of pattern electroretinogram signals of early primary open-angle glaucoma in discrete wavelet transform coefficients domain.

Int Ophthalmol 2019 Feb 6. Epub 2019 Feb 6.

Department of Optometry, School of Rehabilitation Science, Iran University of Medical Sciences, Tehran, Iran.

Purpose: To evaluate discrete wavelet transform coefficients and identify descriptors of pattern electroretinogram (PERG) waveforms in order to determine PERG characteristics for optimizing the diagnosis of early primary open-angle glaucoma (POAG).

Methods: Pattern electroretinogram was performed in 30 normal eyes and 30 eyes with primary open-angle glaucoma according to the ISCEV protocol. The check size was 0. Read More

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http://dx.doi.org/10.1007/s10792-019-01077-wDOI Listing
February 2019

Rates of Ganglion Cell-Inner Plexiform Layer Thinning in Normal, Open-Angle Glaucoma and Pseudoexfoliation Glaucoma Eyes: A Trend-Based Analysis.

Invest Ophthalmol Vis Sci 2019 Feb;60(2):599-604

Department of Ophthalmology, Seoul National University College of Medicine, Seoul, Korea.

Purpose: The purpose of this study was to determine the rate of ganglion cell-inner plexiform layer (GCIPL) thinning by Cirrus high-definition optical coherence tomography (HD-OCT) in normal eyes and open-angle glaucoma (OAG) and pseudoexfoliation glaucoma (PXG) eyes.

Methods: This was a longitudinal observational study. We evaluated 282 subjects who visited a glaucoma clinic of a tertiary hospital in Korea: 60 healthy eyes, 193 medically treated OAG eyes, and 29 medically treated PXG eyes with a minimum 3-year follow-up involving serial spectral-domain OCT measurement of GCIPL thickness. Read More

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http://dx.doi.org/10.1167/iovs.18-25296DOI Listing
February 2019

Intermediate Results of iStent or iStent inject Implantation Combined with Cataract Surgery in a Real-World Setting: A Longitudinal Retrospective Study.

Ophthalmol Ther 2019 Feb 5. Epub 2019 Feb 5.

Federal University of Juiz de Fora, Juiz de Fora, MG, Brazil.

Introduction: In this real-world, retrospective, comparative study we evaluated 6-month performance and safety in consecutive eyes following implantation of the iStent® or iStent inject® trabecular micro-bypass device with concomitant cataract surgery.

Methods: Performance outcomes included intraocular pressure (IOP) reduction; glaucoma medication reduction; proportions of eyes achieving an IOP of < 18, < 16, < 14, or < 12 mmHg; and proportions of eyes on 0, 1, 2, or ≥ 3 medications. Safety outcomes included adverse events, secondary surgeries, and best-corrected visual acuity (BCVA). Read More

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http://dx.doi.org/10.1007/s40123-019-0166-xDOI Listing
February 2019

[Experience of combined laser treatment for pigmentary glaucoma].

Vestn Oftalmol 2018 ;134(6):68-71

Tambov branch of S.N. Fyodorov Eye Microsurgery Federal State Institution, 1 Rasskazovskoe highway, Tambov, Russian Federation, 392000; Tambov State University named after G.R. Derzhavin, Medical Institute, 93 Sovetskaya St., Tambov, Russian Federation, 392000.

Purpose: To analyze the results of combined laser treatment for pigmentary glaucoma using laser iridectomy (LIE) and selective laser trabeculoplasty (SLT).

Material And Methods: The two-stage laser treatment was performed in 12 patients (22 eyes) with pigmentary glaucoma (primary stage - 19 eyes, advanced - 3 eyes). The first stage consisted of LIE; after 5. Read More

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http://dx.doi.org/10.17116/oftalma201813406168DOI Listing
January 2018
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[Results of neuroprotective therapy in primary open-angle glaucoma].

Vestn Oftalmol 2018 ;134(6):53-58

Orenburg State Medical University, Ministry of Health, 6 Sovetskaya St., Orenburg, Russian Federation, 460000.

Purpose: To determine the relationships between the changes in functional parameters of vision that occur in primary open-angle glaucoma (POAG) patients on neuroprotective therapy.

Material And Methods: The study included 146 patients with stages I-III POAG aged 40 to 85 years. The patients were randomly divided into the study group and the control group at 2:1 ratio. Read More

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http://dx.doi.org/10.17116/oftalma201813406153DOI Listing
January 2018
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[Clinical and functional results of bifocal IOLs implanted during combined cataract and glaucoma surgery].

Vestn Oftalmol 2018 ;134(6):46-52

Excimer Ophthalmologic Clinic, 3/1 Marksistskaya St., Moscow, Russian Federation, 109147.

At present, implantation of multifocal IOLs in patients with primary open-angle glaucoma (POAG) remains questionable.

Purpose: To comparatively analyze the clinical and functional effectiveness of bifocal IOLs implanted during combined cataract and glaucoma surgery.

Material And Methods: The prospective study included 41 patients (75 eyes) with presbyopia and POAG who underwent one-stage cataract phacoemulsification with implantation of a multifocal IOL and non-penetrating deep sclerectomy (NPDS) with lens capsule. Read More

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http://dx.doi.org/10.17116/oftalma201813406146DOI Listing
January 2018
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Peripapillary Retinal Nerve Fiber Layer Thickness in Patients with Alzheimer's Disease: A Comparison of Eyes of Patients with Alzheimer's Disease, Primary Open-Angle Glaucoma, and Preperimetric Glaucoma and Healthy Controls.

Med Sci Monit 2019 Feb 5;25:1001-1008. Epub 2019 Feb 5.

Department of Psychiatry, Collegium Medicum, Nicolaus Copernicus University, Bydgoszcz, Poland.

BACKGROUND The aim of this study was to assess and compare peripapillary retinal nerve fiber layer (RNFL) thickness in patients with Alzheimer's disease (AD), primary open-angle glaucoma (POAG), preperimetric glaucoma (PPG), and healthy controls with the use of Spectral Domain Optical Coherence Tomography (SD-OCT). MATERIAL AND METHODS Thirty patients with AD, 30 patients with POAG, 30 patients with PPG, and 30 healthy controls were enrolled in this cross-sectional study. Only 1 randomly selected eye of each patient was analyzed. Read More

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http://dx.doi.org/10.12659/MSM.914889DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6373520PMC
February 2019

Intraocular pressure-lowering effects of imidazo[1,2-a]- and pyrimido[1,2-a]benzimidazole compounds in rats with dexamethasone-induced ocular hypertension.

Eur J Pharmacol 2019 Feb 1;850:75-87. Epub 2019 Feb 1.

International Medical University, IMU Clinical School, Seremban, Malaysia.

Ocular hypertension is believed to be involved in the etiology of primary open-angle glaucoma. Although many pharmaceutical agents have been shown to be effective for the reduction of intraocular pressure (IOP), a significant opportunity to improve glaucoma treatments remains. Thus, the aims of the present study were: (1) to evaluate the IOP-lowering effect of four compounds RU-551, RU-555, RU-839 (pyrimido[1,2-a]benzimidazole), and RU-615 (imidazo[1,2-a]benzimidazole) on steroid-induced ocular hypertension in rats after single drop and chronic applications; and (2) to test in silico and in vitro conventional rho-associated kinase (ROCK) inhibitory activity of the selected compound. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00142999193008
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http://dx.doi.org/10.1016/j.ejphar.2019.01.059DOI Listing
February 2019
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The EX-PRESS glaucoma shunt versus nonpenetrating deep sclerectomy with Esnoper implant in combined surgery for open-angle glaucoma: a prospective randomized study.

Acta Ophthalmol 2019 Feb 3. Epub 2019 Feb 3.

Department of Ophthalmology, University of Navarra Clinic, Pamplona, Spain.

Purpose: To report 1-year treatment outcomes of P50 EX-PRESS implant versus nonpenetrating deep sclerectomy (NPDS) with Esnoper V2000 combined with phacoemulsification.

Design: Randomized, prospective and multicentre clinical trial.

Methods: Settings: Six clinical centres. Read More

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http://dx.doi.org/10.1111/aos.14023DOI Listing
February 2019

Age-related aqueous humor (AH) and lens epithelial cell/capsule protein carbonylation and AH protein concentration in cataract patients who have pseudoexfoliative diseases.

Mol Vis 2018 31;24:890-901. Epub 2018 Dec 31.

Department of Biology, University of Patras, Patras, Greece.

Purpose: The aim of this study is to investigate the age-correlation of oxidative stress (OS, assessed by the accumulative OS damage marker protein carbonyls) in aqueous humour (AH; together with protein concentration) and lens epithelial cells plus capsule (LECs/capsule) in patients with cataract (CAT), and also suffering from pseudoexfoliation syndrome (PEX), primary open-angle glaucoma (POAG) and pseudoexfoliation glaucoma (PXG).

Methods: AH samples from 78 male/female patients (21, 20, 19 and 18 with CAT, PEX, PXG, and POAG, respectively), and LECs/capsule samples from 104 male/female patients (34, 32, 18, and 20 with CAT, PEX, PXG and POAG, respectively) were collected during phacoemulsification CAT surgery. Average protein carbonyl concentrations were measured in patients grouped in 5-year age intervals (ranging from 56-60 to 86-90). Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334981PMC
December 2018

Trabecular microbypass stent implantation in pseudophakic eyes with open-angle glaucoma: Long-term results.

J Cataract Refract Surg 2019 Jan 29. Epub 2019 Jan 29.

From the Sanford School of Medicine (Ferguson) and the School of Health Sciences (Sudhagoni), University of South Dakota, and Vance Thompson Vision (Ibach, Schweitzer, Karpuk, Stephens, Berdahl), Sioux Falls, South Dakota, USA.

Purpose: To evaluate the long-term safety and efficacy of a trabecular microbypass stent as a sole procedure in pseudophakic eyes with open-angle glaucoma.

Setting: Private practice; Sioux Falls, South Dakota, USA.

Design: Retrospective, consecutive case series. Read More

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http://dx.doi.org/10.1016/j.jcrs.2018.11.005DOI Listing
January 2019
1 Read
2.722 Impact Factor

Increased Aqueous Humor Symmetric Dimethylarginine Level in Patients with Primary Open Angle Glaucoma.

Curr Eye Res 2019 Feb 1:1-4. Epub 2019 Feb 1.

c Department of Biochemistry , Inonu University School of Medicine , Malatya , Turkey.

Purpose: To evaluate the asymmetric dimethylarginine (ADMA), symmetric dimethylarginine (SDMA) and L-arginine (L-Arg) levels both in plasma and aqueous humor of primary open angle glaucoma (POAG) patients and matched controls.

Patients And Methods: 25 primary open angle glaucoma patients and 42 control cases with senile cataract were included in the study. Plasma and aqueous humor ADMA, SDMA and L-Arg levels of the participants were measured by using liquid chromatography-tandem mass spectrometry. Read More

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http://dx.doi.org/10.1080/02713683.2019.1578378DOI Listing
February 2019

Cataract Surgery and Rate of Visual Field Progression in Primary Open-Angle Glaucoma.

Am J Ophthalmol 2019 Jan 28. Epub 2019 Jan 28.

Stein Eye Institute, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, USA. Electronic address:

Purpose: To test the hypothesis that cataract surgery slows the apparent rate of visual field (VF) decay in primary open-angle glaucoma patients compared with rates measured during cataract progression.

Design: Retrospective cohort study.

Methods: Consecutive open-angle glaucoma patients who underwent cataract surgery and who had ≥4 VFs and ≥3 years of follow-up before and after surgery were retrospectively reviewed. Read More

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http://dx.doi.org/10.1016/j.ajo.2019.01.019DOI Listing
January 2019
3 Reads