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Graefes Arch Clin Exp Ophthalmol 2019 Mar 27. Epub 2019 Mar 27.

Ocular Melanoma Center, Retina Service, Mass Eye and Ear, 243 Charles Street., Boston, MA, 02114, USA.

Purpose: The diagnosis of iris melanoma can be difficult, with no established diagnostic criteria currently available. Careful monitoring of patients with suspicious iris lesions is one approach to managing these tumors. We determined the risk of malignant transformation and melanoma-related mortality in patients under observation to evaluate the validity of this management approach. Read More

Graefes Arch Clin Exp Ophthalmol 2019 Mar 27. Epub 2019 Mar 27.

Department of Radiation Therapy, University Hospital Essen, Hufelandstrasse 55, 45147, Essen, Germany.

Background: The management of conjunctival melanoma is challenging and frequently ends in exenteration. The aim of this retrospective study was to evaluate the long-term results of proton beam radiation with regard to various clinical parameters.

Methods: Eighty-nine patients with extended conjunctival melanoma (≥T2) and multifocal bulbar located tumors (T1c/d) were treated consecutively with proton radiotherapy (dose 45 Gy). Read More

Arch Med Sci 2019 Mar 2;15(2):449-456. Epub 2018 Feb 2.

School of Medicine, University of Sarajevo, Sarajevo, Bosnia and Herzegovina.

Introduction: The aim of the study was to investigate the effects of vascular endothelial growth factor (VEGF) concentration in vitreous on postoperative complications after pars plana vitrectomy (PPV).

Material And Methods: Ninety subjects were surgically treated with PPV and followed up for 12 months at the Clinical Centre University Sarajevo, Clinic for Eye Disease. Exclusion criteria were presence of other eye diseases, systemic acute/chronic inflammatory conditions, or malignant neoplasms; previously performed PPV surgery; previously received intravitreal or systemic anti-VEGF therapy. Read More

Rom J Ophthalmol 2018 Oct-Dec;62(4):260-269

OcuCenter Ophthalmological Clinic, Cluj-Napoca, Romania.

The authors are discussing over 80 articles that they have published in the last 5 years in the renowned ophthalmic journals worldwide, which have approached, for the first time in the ophthalmic literature, the following 4 topics: the acute central/ hemicentral retinal vein occlusion, the therapeutic interventions in the fellow eye of patients with unilateral malignant glaucoma, the persistent diabetic macular edema, and the current researches in patients with neovascular age-related macular degeneration. Read More

J Fr Ophtalmol 2019 Apr 14;42(4):391-403. Epub 2019 Mar 14.

Service d'ophtalmologie, centre hospitalier national d'ophtalmologie des Quinze-Vingts, 28, rue de Charenton, 75012 Paris, France; Service d'ophtalmologie, université de Versailles Saint-Quentin-en-Yvelines, hôpital Ambroise-Paré, AP-HP, 9, avenue Charles-De-Gaulle, 92100 Boulogne Billancourt, France; Inserm, U968, université UPMC Paris VI, UMR S 968, institut de la vision , CNRS, UMR 7210, 75012 Paris, France. Electronic address:

Purpose: The purpose of this study was to analyze the change in intraocular pressure (IOP) and glaucoma medications using the XEN Gel Stent as a solo procedure or in association with phacoemulsification in patients with chronic open angle glaucoma (OAG).

Methods: We included cohort studies with at least one year of follow-up in patients with primary open angle glaucoma (POAG), pseudo-exfoliative glaucoma (PXG) or pigmentary glaucoma (PG) who received a XEN® gel stent. The main outcome measure was IOP reduction at 12 months follow-up. Read More

Pharmacol Res 2019 Mar 13;144:19-50. Epub 2019 Mar 13.

Blue Ridge Institute for Medical Research, 3754 Brevard Road, Suite 116, Box 19, Horse Shoe, NC 28742-8814, United States. Electronic address:

Because mutations, overexpression, and dysregulation of protein kinases play essential roles in the pathogenesis of many illnesses, this enzyme family has become one of the most important drug targets in the past 20 years. The US FDA has approved 48 small molecule protein kinase inhibitors, nearly all of which are orally effective with the exceptions of netarsudil (which is given as an eye drop) and temsirolimus (which is given intravenously). Of the 48 approved drugs, the majority (25) target receptor protein-tyrosine kinases, ten target non-receptor protein-tyrosine kinases, and 13 target protein-serine/threonine protein kinases. Read More

J Glaucoma 2019 Mar;28(3):e44-e45

Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Palm Beach Gardens, FL.

Purpose: We describe a patient with primary angle-closure glaucoma who developed malignant glaucoma following laser peripheral iridotomy.

Methods: A 58-year-old male presented with peripheral and central anterior chamber shallowing following an uncomplicated Nd: YAG laser peripheral iridotomy. Intraocular pressure (IOP) and B-scan echography were normal, and there was -1. Read More

J Ophthalmic Vis Res 2019 Jan-Mar;14(1):32-37

Department of Ophthalmology and Visual Sciences, Washington University, St Louis, MO, USA.

Purpose: To investigate a potential link between the incidence of malignant glaucoma after cataract surgery and seasonal variations in daylight.

Methods: In total, 18,374 uncomplicated cataract surgeries were performed between June 2008 and June 2013 at an ambulatory surgery center in Toronto. Toronto's average monthly daylight over that time period-in hours per day for each month-was determined. Read More

Indian J Ophthalmol 2019 Mar;67(3):350-357

Department of Ocular Tumor, Orbital Disease and Ophthalmic Radiation Therapy, The New York Eye Cancer Center, New York City, New York, USA.

Purpose: The purpose of this study is to describe the clinical characteristics, multimodality imaging findings, and clinical course of iris varices.

Methods: Retrospective, noncomparative, observational case series of 28 eyes of 26 patients with iris varices, diagnosed between 2007 and 2017, has been used.

Results: The mean (±SD) age was 58. Read More

J Fr Ophtalmol 2019 Feb 22;42(2):e37-e46. Epub 2019 Jan 22.

Service d'ophtalmologie, centre hospitalier national d'ophtalmologie des Quinze-Vingts, IHU ForeSight, , 28, rue de Charenton, 75012 Paris, France; Service d'ophtalmologie, hôpital Ambroise-Paré, université de Versailles Saint-Quentin-en-Yvelines, AP-HP, 9, avenue Charles-De-Gaulle, 92100 Boulogne-Billancourt, France; Inserm, U968, université UPMC Paris VI, UMR S 968, institut de la vision, CNRS, UMR 7210, 75012 Paris, France. Electronic address:

Purpose: The purpose of this study was to analyze the change in intraocular pressure (IOP) and glaucoma medications using the XEN Gel Stent as a solo procedure or in association with phacoemulsification in patients with chronic open angle glaucoma (OAG).

Methods: We included cohort studies with at least one year of follow-up in patients with primary open angle glaucoma (POAG), pseudo-exfoliative glaucoma (PXG) or pigmentary glaucoma (PG) who received a XEN gel stent. The main outcome measure was IOP reduction at 12 months follow-up. Read More

Ocul Oncol Pathol 2019 Jan 2;5(1):20-27. Epub 2018 May 2.

Stein Eye and Doheny Eye Institutes, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, USA.

Aim: We report patient safety and intraocular pressure (IOP) control after placement of a glaucoma drainage device (GDD) in eyes with a history of treated malignant uveal melanoma.

Methods: A retrospective review of the records of patients with uveal melanoma was performed. Outcomes were local tumor recurrence, rate of metastases, and to-nometric success, based on survival curves, defined as IOP < 21 mm Hg. Read More

J Ophthalmol 2018 22;2018:9189585. Epub 2018 Nov 22.

Department of Ophthalmology, The First Affiliated Hospital of Zhejiang Chinese Medical University, 54 Youdian Road, Hangzhou, Zhejiang 310006, China.

Purpose: To characterize new combined surgical techniques for the management of malignant glaucoma.

Methods: In a retrospective, interventional case series, goniosynechialysis, peripheral iridectomy, zonulo-hyaloidectomy, and anterior vitrectomy, with or without peripheral capsulectomy, were performed on nine eyes. If the patient was phakic, we performed both phacoemulsification and intraocular lens implantation. Read More

Arch Soc Esp Oftalmol 2019 Mar 18;94(3):134-137. Epub 2018 Dec 18.

FISABIO Oftalmología Médica, Valencia, España.

Minimally invasive glaucoma surgery for chronic open-angle glaucoma treatment tries to reduce the amount of chronic topical drug treatment, delaying invasive glaucoma surgery and diminishing the number of surgical complications. XEN45 uses subconjunctival drainage in order to reduce intraocular pressure. The report is presented of a patient following phacoemulsification, intraocular lens implantation and XEN45 implant. Read More

BMJ Open Ophthalmol 2018 23;3(1):e000174. Epub 2018 Nov 23.

Dipartimento Neuromuscoloscheletrico e Organi di Sensi, Università degli Study di Firenze, Florence, Italy.

Objective: Intraocular lens (IOL) repositioning using a closed-eye approach could be carried out in some selected cases. Our study focuses on the efficacy and safety of a IOL closed-eye repositioning technique using scleral suture, which is performed using a trocar as an intrastromal limbal guide.

Methods And Analysis: Thirty-one eyes of 31 patients with late IOL dislocation operated on between January 2015 and May 2017 were included in this retrospective non-comparative consecutive case series study. Read More

Arch Soc Esp Oftalmol 2019 Jan 14;94(1):33-36. Epub 2018 Nov 14.

Servicio de Oftalmología, Hospital Costa del Sol, Marbella, Málaga, España.

Sclerochoroidal calcification (SCC) is uncommon and benign. It is usually detected in a routine examination, finding multiple yellow-white lesions in the upper temporal region of the retina in middle-aged and elderly men. A case report is presented of a 79 year-old male patient, who during a routine examination with a pseudoexfoliative glaucoma in the right eye, as well as raised white-yellow subretinal lesions in the upper temporal region in both eyes. Read More

Medicina (Kaunas) 2018 Sep 5;54(4). Epub 2018 Sep 5.

Department of Ophthalmology, Medical Academy, Lithuanian University of Health Sciences, 50161 Kaunas, Lithuania.

Despite established common risk factors, malignant glaucoma (MG) remains a rare condition with challenging management. We aimed to analyze differences in risk factors for MG after different surgeries and outcomes after pars plana vitrectomy (PPV). This retrospective study included cases of MG treated with PPV between January 2005 and December 2015 in the Department of Ophthalmology, Lithuanian University of Health Sciences, Kaunas, Lithuania. Read More

Neoplasma 2018 Nov 4;65(6):965-971. Epub 2018 Sep 4.

Department of Ophthalmology, Faculty of Medicine, Comenius University, Bratislava, Slovakia.

This paper presents the long-term results of single dose stereotactic radiosurgery for intraocular uveal malignant melanoma, and summarizes the results of the retrospective study in 170 Slovak patients. A group of uveal melanoma patients (149 choroidal melanoma, 21 ciliary body melanoma) from 20 to 92 years of age with 59 year median were treated in 2001-2016. There were 81males (47. Read More

Clin Ophthalmol 2018 11;12:1775-1784. Epub 2018 Sep 11.

Birmingham Institute for Glaucoma Research, Institute of Translational Medicine, Birmingham, UK,

Objective: The objective of the study was to present evidence of successful skills transfer of the Moorfields Safer Surgery System (MSSS) from the UK to Trinidad and Tobago and the safety and efficacy of this technique.

Methods: Hospital-based retrospective, consecutive, non-comparative case series study of 33 eyes (24 African-Caribbean patients; 16 male patients) with primary open-angle glaucoma undergoing trabeculectomy + mitomycin C (MSSS) by a single surgeon with UK Glaucoma Fellowship training. The clinical outcome measures included intraocular pressure (IOP), bleb morphology, postsurgical interventions, postoperative complications, and best-corrected visual acuity (BCVA) at the final follow-up. Read More

Int J Retina Vitreous 2018 5;4:29. Epub 2018 Sep 5.

1Smt. Kanuri Santhamma Centre for Vitreo-Retinal Diseases, L V Prasad Eye Institute, Hyderabad, 500034 India.

Background: The close structural and microcirculatory co-relation between anterior and posterior segments of eye make them very vulnerable to complications when one of them is affected surgically. With the advent of anti-fibrotic agents in the management of glaucoma, the rates of vitreoretinal complications have become more frequent.

Main Body: Common retinal complications after glaucoma surgeries include choroidal detachment; ocular decompression retinopathy; haemorrhagic choroidal detachment; hypotony maculopathy; malignant glaucoma; vitreous haemorrhage; bleb endophthalmitis; retinal detachment. Read More

Ophthalmic Res 2018 5;60(3):161-168. Epub 2018 Sep 5.

Purpose: The aim of this study was to evaluate the choroidal thickness (CT) and its determinants in primary angle closure glaucoma (PACG) eyes with and without malignant glaucoma (MG).

Methods: In this cross-sectional study, we enrolled 25 patients with bilateral primary angle closure (PAC) diseases; 1 eye of each patient was diagnosed with PACG initially and later with MG after trabeculectomy, and the fellow eyes were diagnosed with PACG, PAC, or PAC suspect. Thirty-seven eyes from 37 PACG patients were recruited as controls. Read More

Am J Ophthalmol Case Rep 2018 Dec 13;12:24-27. Epub 2018 Aug 13.

Duke University, Department of Ophthalmology, Durham, NC, USA.

Purpose: Patients with chronic narrow angle glaucoma (CNAG) are at increased risk of developing aqueous misdirection (AM) following intraocular surgery. We present a retrospective case series on the use of posterior capsulorrhexis with core vitrectomy by an anterior approach (CAV) at the time of cataract extraction with or without glaucoma surgery as a prophylactic measure for the prevention of AM in CNAG.

Methods: Retrospective case series of six phakic eyes in four patients with CNAG and other risk factors for AM who underwent posterior capsulorrhexis and CAV at the time of cataract surgery with or without glaucoma surgery. Read More

Int J Ophthalmol 2018 18;11(8):1433-1434. Epub 2018 Aug 18.

Department of Ophthalmology, University of Medicine, Cluj-Napoca 400012, Romania.

Am J Ophthalmol Case Rep 2018 Sep 21;11:124-127. Epub 2018 Jun 21.

Department of Ophthalmology and Vision Science, University of California at Davis, Sacramento, CA, USA.

Purpose: To report a case of metastatic intraocular medulloepithelioma successfully treated with neoadjuvant chemotherapy, superficial parotidectomy, and enucleation.

Observations: A 5-year-old male with history of cataract surgery, glaucoma drainage device, endocyclophotocoagulation, scleral patch grafting, and chronic posterior "inflammation" in a blind left eye presented with a rapidly enlarging painful mass under the left upper eyelid. Biopsy of the conjunctival mass and fine needle aspiration of an enlarged preauricular lymph node revealed medulloepithelioma, which was also seen in the left parotid gland on positron emission tomography (PET) scan. Read More

J Ophthalmic Vis Res 2018 Jul-Sep;13(3):231-235

Ocular Tissue Engineering Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Purpose: To evaluate the safety and efficacy of clear corneal approach irido-zonulo-hyaloido-vitrectomy, which we named "mini-vitrectomy," in the management of pseudophakic aqueous misdirection.

Methods: In this retrospective, non-comparative interventional case series, 24 eyes with diagnosis of pseudophakic aqueous misdirection were enrolled. Medical therapy with cycloplegics and laser therapy, including posterior capsulotomy and hyaloidotomy, was not effective in the management of the condition. Read More

Am J Ophthalmol Case Rep 2018 Sep 26;11:56-60. Epub 2018 May 26.

Department of Ophthalmology, Storm Eye Institute, Medical University of South Carolina, Charleston, SC, USA.

Purpose: To describe the natural history and management of a rare case of iris melanoma in a pediatric patient.

Observations: A Caucasian female presented with left pupillary abnormalities at age 7, progressive iris changes at age 9, and markedly elevated intraocular pressure with advanced optic nerve cupping at 11 years of age. She was found to have a pigmented lesion overlying her iris and invading her angle. Read More

Oman J Ophthalmol 2018 May-Aug;11(2):178-180

Ophthalmology and Vision Sciences, Division of Clinical Neurosciences, B Floor, EENT Centre, Queen's Medical Centre, University of Nottingham, Nottingham, UK.

Malignant glaucoma (MG), also known as aqueous misdirection and cilio-vitreo-lenticular block, is an infrequent cause of secondary angle closure glaucoma. Despite conventional treatment, it often has a poor visual outcome. It is recognized clinically by raised intraocular pressure associated with shallowing of the peripheral and central anterior chamber in the presence of a patent peripheral iridotomy/iridectomy. Read More

Med Sci Monit 2018 Jun 10;24:3916-3921. Epub 2018 Jun 10.

Department of Ophthalmology, Wuxi No. 9 People's Hospital Affiliated to Soochow University, Wuxi, Jiangsu, China (mainland).

BACKGROUND Currently, safe and effective surgical treatment of malignant glaucoma is still under investigation. This study evaluated the clinical efficacy of ciliary ring incision combined with modified partial pars plana vitrectomy in the treatment of malignant glaucoma. The technique is particularly useful in the treatment of "phakic" patients with malignant glaucoma, especially those who wish to preserve the natural lens. Read More

Melanoma Res 2018 08;28(4):359-362

Moorfields Eye Hospital.

This report concerns a 49-year-old female with cutaneous malignant melanoma and systemic metastases. These resolved following combination immunotherapy with ipilimumab and nivolumab. She subsequently experienced unilateral floaters, an increase in iris pigmentation and pigmentary glaucoma. Read More

Indian J Ophthalmol 2018 04;66(4):565-567

Department of Ophthalmology, Christian Medical College, Vellore, Tamil Nadu, India.

Positive vitreous pressure due to misdirection of aqueous or choroidal effusion leads to shallowing of the anterior chamber (AC) before or during anterior segment surgeries. This shallow AC if not addressed makes surgery difficult and increases the risk of surgical complications. Methods to prevent and manage this condition described in literature are not without problems. Read More

BMC Ophthalmol 2018 Feb 23;18(1):54. Epub 2018 Feb 23.

Department of Ophthalmology, Zhejiang Chinese Medical Hospital, Hangzhou, 31006, China.

Background: The management of eyes with nanophthalmos is a dilemma for ophthalmologists due to various complications, especial the eye with malignant glaucoma. We report a case of effective treatment for malignant glaucoma in nanophthalmos.

Case Presentation: An 82-year-old man was performed phacoemulsification in the right eye with normal ocular pressure and nanophthalmos. Read More

Indian J Ophthalmol 2018 Feb;66(2):317-319

Department of Ophthalmology, Laboratory Technician, Sri Sankaradeva Nethralaya, Guwahati, Assam, India.

We describe a case of spontaneous hyphema associated with anterior uveitis presents in a 69-year old female as the prominent sign of the intraocular spread of systemic diffuse large B-cell lymphoma (DLBCL). She had a history of diabetes and initially misdiagnosed as neovascular glaucoma. Clinical history of systemic lymphoma, characteristic findings on B-scan ultrasonography and magnetic resonance imaging scan, and identification of atypical lymphoid cells in aqueous sample established the diagnosis of intraocular metastasis of systemic DLBCL. Read More

Clin Exp Ophthalmol 2018 Sep 8;46(7):811-813. Epub 2018 Mar 8.

Singapore Eye Research Institute, Singapore.

Pan Afr Med J 2017 22;28:66. Epub 2017 Sep 22.

Department of Paediatrics and Adolescent Health, Faculty of Medicine, University of Botswana, Gaborone, Botswana.

Introduction: Retinoblastoma is a primary malignant intraocular neoplasm that arise from immature retinoblasts with in developing retina. The commonest presenting sign in developing country is proptosis which is the late presenting sign. We report presenting signs of retinoblastoma in Ethiopian children seen at a tertiary level teaching hospitals in Ethiopia. Read More

J Ophthalmol 2017 24;2017:9616738. Epub 2017 Aug 24.

Department of Ophthalmology, Military Institute of Medicine, Szaserów Street 128, 04-141 Warsaw, Poland.

Purpose: The aim of this study was twofold: first, to evaluate the predisposing factors for occurrence of malignant glaucoma and second, to compare frequency of malignant glaucoma depending on the type of primary glaucoma surgery.

Methods: Retrospective analysis was performed in 1689 consecutive patients who underwent glaucoma surgery alone or combined with phacoemulsification. Data collected included the type of surgery, width of the filtration angle, presence or absence of malignant glaucoma in the postoperative period, and time from the primary surgery to malignant glaucoma occurrence. Read More

Graefes Arch Clin Exp Ophthalmol 2018 Jan 6;256(1):135-154. Epub 2017 Nov 6.

Department of Ophthalmology, Medical University of Gdańsk, Gdańsk, Poland.

Purpose: To summarize our current understanding of the specific pathogenic mechanisms of the fluid misdirection syndrome and possible treatment methods.

Methods: We used the PubMed web platform to find relevant studies using the following keywords: infusion misdirection syndrome, aqueous misdirection syndrome, ciliary block, ciliovitreal block, capsular block, intraoperative fluid misdirection, subcapsular fluid entrapment, acute intraoperative rock-hard eye syndrome, positive vitreous pressure glaucoma, and malignant glaucoma. Other publications were also considered as a potential source of information when referenced in relevant articles. Read More

BMJ Case Rep 2017 Oct 13;2017. Epub 2017 Oct 13.

Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India.

We report a case of a 24-year-old male patient with post-laser assisted in situ keratomileusis (LASIK) culture-proven mycotic keratitis who developed pupillary block glaucoma on day 19 of medical management. The case was initially managed with multiple Nd-Yag peripheral iridotomy along with systemic and topical antiglaucoma medications. However, an emergency therapeutic penetrating keratoplasty (TPK) with lens extraction was done in view of persistently raised intraocular pressure (IOP) and seclusio pupillae. Read More

Vet Ophthalmol 2018 Sep 3;21(5):535-538. Epub 2017 Oct 3.

Section of Pathology, Department of Clinics and Surgery, Veterinary School, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.

An indoor-only, 5-year-old, spayed female domestic shorthair cat presented for an ophthalmic examination of the left eye. An intraocular tumor with secondary glaucoma and blindness was diagnosed; the globe was enucleated and sent for histopathological examination. Gross examination revealed a solid white mass filling the entire vitreous space and replacing the iris and ciliary body. Read More

Acta Ophthalmol 2018 Mar 21;96(2):154-160. Epub 2017 Aug 21.

Department of Ophthalmology, Turku University Hospital, University of Turku, Turku, Finland.

Purpose: To study the long-term outcome of deep sclerectomy with and without mitomycin-C (MMC) in patients with normal-tension glaucoma (NTG).

Methods: We prospectively analysed consecutive patients randomized to surgery performed either with (MMC group) or without (non-MMC) MMC. Surgery was considered totally successful if, after surgery, the preoperative intra-ocular pressure (IOP) level was reduced by 25% without medication, and a qualified success if medication was required to achieve the same limits. Read More

Medicine (Baltimore) 2017 Jun;96(22):e6953

Department of Ophthalmology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.

Rationale: Drug-induced bilateral angle-closure glaucoma is a rare event and should be treated correctly and promptly to prevent visual loss.

Patient Concerns: We report a rare case of sumatriptan-induced bilateral angle-closure glaucoma in a young woman with migraine, and explore the possible mechanism.

Diagnoses: We describe the clinical outcome of a patient with sumatriptan-induced bilateral angle-closure glaucoma. Read More

Melanoma Res 2017 10;27(5):463-468

aDepartment of Ophthalmology, Faculty of Medicine, Comenius University bDepartment of Stereotactic Radiosurgery, St. Elisabeth Cancer Institute, St. Elisabeth University College of Health and Social Work cDepartment of Medical Physics, Faculty of Medicine, Slovak Medical University dDepartment of Information Systems, Faculty of Management, Comenius University, Bratislava, Slovakia.

Long-term results with linear accelerator LINAC-based stereotactic radiosurgery for intraocular uveal malignant melanoma were assessed. A retrospective study was carried out of patients with uveal melanoma after a 1-day session stereotactic radiosurgery at LINAC in Slovakia. In the period 2001-2015, a group of 150 patients with uveal melanoma (139 choroidal melanoma, 11 ciliary body melanoma) was treated. Read More

Case Rep Ophthalmol 2017 Jan-Apr;8(1):190-194. Epub 2017 Mar 30.

aDepartment of Ophthalmology, Oita University Faculty of Medicine, Yufu, Japan.

We report a rare case with histologically proven melanocytoma of the iris that demonstrated diffuse melanocytic proliferation with uncontrolled secondary glaucoma and investigate the etiology of the intraocular pressure elevation. The patient was a 78-year-old man with a history of darkened iris of his left eye. The intraocular pressure was 39 mm Hg. Read More

Ophthalmic Res 2017 28;58(2):74-80. Epub 2017 Apr 28.

Department of Ophthalmology, RWTH Aachen University, Aachen, Germany.

Purpose: To evaluate the long-term outcome of trabeculectomy with intra- and postoperative 5-fluorouracil (5-FU) application in glaucoma.

Methods: Eighty-six patients with glaucoma planned for primary trabeculectomy with 5-FU and a minimum follow-up of 3 years were retrospectively analyzed. Success rates, postsurgical 5-FU injections, needling procedures, and complications were analyzed. Read More

Ophthalmology 2017 07 1;124(7):1023-1030. Epub 2017 Apr 1.

The New York Eye Cancer Center, New York, New York. Electronic address:

Purpose: To evaluate the patterns of regression of iris melanoma after treatment with palladium-103 (Pd) plaque brachytherapy.

Design: Retrospective, nonrandomized, interventional case series.

Participants: Fifty patients with primary malignant melanoma of the iris. Read More

J Fr Ophtalmol 2017 Apr 23;40(4):264-269. Epub 2017 Mar 23.

Ophthalmology department, Institut du glaucome, university Paris-Descartes, centre hospitalier Paris-Saint-Joseph, 185, rue Raymond-Losserand, 75674 Paris cedex 14, France.

Purpose: Evaluation of high intensity focused ultrasound (HIFU) transscleral cyclocoagulation as an alternative to trabeculectomy in the treatment of refractory chronic angle closure glaucoma (CACG).

Methods: This prospective one armed single center pilot study was conducted on patients with medically uncontrolled CACG who underwent high intensity focused ultrasound (HIFU) cyclocoagulation as first line surgical treatment, using the Eye-OP1 HIFU device (Eyetechcare-Rillieux-la-Pape, France) driven by ultrasound biomicroscopic (UBM) ciliary body localization. All patients had documented progression of their glaucoma despite conventional medical and laser therapy. Read More

Arch Soc Esp Oftalmol 2017 Aug 17;92(8):390-393. Epub 2017 Mar 17.

Servicio de Oftalmología, Hospital Universitario Santa María, Centro Hospitalario Lisboa Norte; Facultad de Medicina, Universidad de Lisboa, Lisboa, Portugal.

Clinical Case: An 85 year-old woman presented with a flat anterior chamber of the left eye, severe ocular hypertension, and a normal ultrasound examination in the day following a penetrating keratoplasty (PK). The clinical status did not respond to maximum medical therapy, laser posterior capsulotomy, anterior hyaloidotomy, and complete 23 G vitrectomy. The patient refused further intervention, and light perception was lost after 6 months of follow-up. Read More

J Ophthalmic Vis Res 2017 Jan-Mar;12(1):117-119

Department of Ophthalmology, St. Barbara Hospital of Soria, Soria, Spain.

Purpose: To report a case of choroidal effusion probably caused by angiotensin receptor II blocker.

Case Report: A 52-year-old man with aplastic anemia and high blood pressure who developed unilateral acute angle closure glaucoma after receiving oral cyclosporine and angiotensin II receptor blocker (losartan). Ophthalmic examination revealed visual acuity of 20/30 in the left eye, mild mydriasis, iris bombe, no anterior chamber reaction, mild conjunctival hyperemia, and the intraocular pressure of 30 mmHg. Read More

Crit Rev Oncol Hematol 2017 Mar 7;111:1-6. Epub 2017 Jan 7.

Research and Scientific Studies Unit, College of Nursing and Allied Health Sciences, Jazan University, Jazan 45142, Saudi Arabia; Department of Biosciences, Jamia Millia Islamia (A Central University), New Delhi 110025, India; Centre for Drug Research, Faculty of Pharmacy, Viikki Biocentre-2, University of Helsinki, Helsinki FI-00014, Finland. Electronic address:

The incidences of melanomas are increasing by leaps and bounds across the globe despite early detection and intervention. The numbers of patients dying from metastatic melanoma have been continually increased over the past thirty years. It has been considered as one of the most therapy-resistant malignancies due to the cross-resistant mechanism developed by the metastatic cells. Read More

Eye (Lond) 2017 Jun 3;31(6):947-955. Epub 2017 Mar 3.

Shri Bhagwan Mahavir Vitreoretinal Services, Medical Research Foundation, Sankara Nethralaya, Chennai, India.

PurposeTo assess outcomes of surgical management of malignant glaucoma in terms of re-formation of anterior chamberMethodsThis was a retrospective analysis of consecutive patients who underwent surgical treatment for malignant glaucoma between January 1995 and December 2013 at a tertiary care ophthalmic institute, with a minimum follow up of 2 months.ResultsFifty eight eyes of 58 patients were included. Fifty two (89. Read More

Free Radic Res 2017 Jan 17;51(1):73-79. Epub 2017 Jan 17.

b Department of Neurology , Multiple Sclerosis Unit, Papageorgiou General Hospital , Thessaloniki , Greece.

Helicobacter pylori (H. pylori) induces reactive oxygen species (ROS) production that contribute to pathogenesis of a variety of H. pylori-related gastric diseases, as shown in animal and human studies. Read More

Semin Ophthalmol 2018 8;33(2):242-252. Epub 2016 Dec 8.

b Glaucoma Services, LV Prasad Eye Institute , Hyderabad , India.

Purpose: To describe an unusual series of complications after glaucoma filtering surgeries with their clinical findings and outcome after tailored non-conventional modes of therapy.

Patients And Methods: Eighteen patients who underwent re-interventions (medical or surgical) after glaucoma filtering surgeries during the period at two tertiary centers, excluding those that required conventional modes of treatment (medical control or re-trabeculectomy, simple wound closure for traumatic wound dehiscence, bleb revision or needling, laser iridotomy), were included. Relevant clinical details with intraoperative videos, intraoperative or postoperative problems, and images with course after re-intervention were retrieved from the hospital database. Read More