Search Our Scientific Publications & Authors

Semin Ophthalmol 2022 Jun 11:1-13. Epub 2022 Jun 11.

VST Centre for Glaucoma Services, L V Prasad Eye Institute, Hyderabad, India.

Purpose: We conducted a systematic search of literature to understand the various methods of imaging of the ciliary body.

Methods: PubMed, Science Direct, Cochrane Library and Google Scholar were searched comprehensively and systematically to find studies related to the various modalities of ciliary body imaging.

Results: The various ciliary body parameters that have been described are Ciliary body thickness, Ciliary body length, ciliary muscle thickness, ciliary process length, ciliary muscle length, ciliary muscle anterior length, trabecular ciliary process distance and Iris ciliary process distance. Read More

Clin Case Rep 2022 Jun 5;10(6):e05810. Epub 2022 Jun 5.

Medical College of Georgia Augusta Georgia USA.

We present a seemingly typical case of bilateral angle closure with elevated intraocular pressures. After cataract surgery, there was axial shallowing, escalating intraocular pressure, anterior displacement of the IOL, and myopic shift in the left eye. Irido-zonulo-hyaloido-vitrectomy resolved the angle closure, normalized intraocular pressure, and corrected the myopic shift. Read More

Surv Ophthalmol 2022 May 26. Epub 2022 May 26.

Department of Ocular Tumor, Orbital Disease and Ophthalmic Radiation Therapy, The New York Eye Cancer Center, 115 East 61st Street, New York City, New York, USA, 10065.

Laser treatment has offered a relatively nonsurgical alternative for eye, life, and vision-sparing treatment of malignant melanoma of the choroid. Historically, the most commonly used forms of lasers were xenon-arc, argon laser, krypton laser, and the more recent transpupillary thermotherapy (TTT) and photodynamic therapy (PDT). Melanomas selected for laser treatment tend to be smaller and visibly accessible, which means these tumors are usually located in the posterior choroid. Read More

iScience 2022 Apr 22;25(4):104149. Epub 2022 Mar 22.

Department of Ophthalmology, Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China.

Glaucoma is one of the most common causes of irreversible blindness. It is acknowledged that lowering intraocular pressure (IOP) is the effective treatment to slow glaucoma disease progression. The main obstacle of existing drugs is that the effect of reducing IOP does not last long. Read More

Ophthalmol Glaucoma 2022 Apr 7. Epub 2022 Apr 7.

Department of Vitreo-Retina, Aravind Eye Hospital and Postgraduate Institute of Ophthalmology, Madurai, Tamil Nadu, India. Electronic address:

BMC Ophthalmol 2022 Apr 2;22(1):150. Epub 2022 Apr 2.

Eye Center of Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, China.

Background: Although primary angle-closure glaucoma (PACG) mainly occurs in elderly people, diagnosis of PACG in young patients is not uncommon. So far, there is no article specialized on the ocular anatomical characteristics in these patients.In this study, ocular anatomical characteristics in young PACG patients are analyzed. Read More

Graefes Arch Clin Exp Ophthalmol 2022 Mar 29. Epub 2022 Mar 29.

Ophthalmology Department, Meir Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

Purpose: The study aims to review the efficacy, safety, and technique of Nd:YAG laser vitreolysis for the management of malignant glaucoma (MG).

Methods: We performed a search of electronic databases for all published studies which included technical specifications of Nd:YAG laser application for MG. Individual patient data was extracted and evaluated in a weighted pooled analysis. Read More

Pak J Med Sci 2022 Jan;38(2):362-368

Saba Jamal, Diplomate American Board of Haematology, Diplomate American Board of Anatomic and Clinical Pathology, Department of Histopathology, Indus Hospital & Health Network, Korangi, Karachi, Pakistan.

Background & Objectives: Retinoblastoma is a malignant intraocular tumor and its treatment requires a multidisciplinary approach. Chemotherapy is an important modality in treatment of retinoblastoma. The purpose of this study was to assess the histopathological changes in retinoblastomas treated with chemotherapy along with correlation of comorbid conditions with high risk histopathological factors (HRF). Read More

Cureus 2022 Jan 28;14(1):e21679. Epub 2022 Jan 28.

Department of Ophthalmology and Visual Science, Universiti Sains Malaysia, School of Medical Sciences, Kota Bharu, MYS.

Successful irido-zonulo-hyaloidotomy in combination with complete pars plana vitrectomy in malignant glaucoma may lead to better intraocular pressure (IOP) control and a promising visual outcome. We report a case of an 81-year-old woman who presented with a ten-day history of right eye redness and blurring of vision associated with throbbing pain. An ocular examination revealed right-eye visual acuity (VA) of 6/60. Read More

J Curr Glaucoma Pract 2021 Sep-Dec;15(3):164-167

Department of Ophthalmology and Visual Science, Yale School of Medicine, New Haven, Connecticut, USA.

Aim And Objective: To report an unusual and difficult case of malignant glaucoma induced by a traumatic mature cataract that had migrated into the anterior chamber in a developmentally delayed patient.

Background: Malignant glaucoma can present due to multiple mechanisms, including trauma-induced cataract migration into the anterior chamber.

Case Description: A developmentally delayed female in her 40s with a history of self-abuse was found to have malignant glaucoma in the setting of a traumatic cataract that had migrated in front of the iris into the anterior chamber. Read More

Molecules 2022 Jan 26;27(3). Epub 2022 Jan 26.

Natural and Medical Sciences Research Center, University of Nizwa, P.O Box 33, Birkat Al Mauz, Nizwa 616, Oman.

Carbonic anhydrase-II (CA-II) is strongly related with gastric, glaucoma, tumors, malignant brain, renal and pancreatic carcinomas and is mainly involved in the regulation of the bicarbonate concentration in the eyes. With an aim to develop novel heterocyclic hybrids as potent enzyme inhibitors, we synthesized a series of twelve novel 3-phenyl-β-alanine 1,3,4-oxadiazole hybrids (-), characterized by H- and C-NMR with the support of HRESIMS, and evaluated for their inhibitory activity against CA-II. The CA-II inhibition results clearly indicated that the 3-phenyl-β-alanine 1,3,4-oxadiazole derivatives - exhibited selective inhibition against CA-II. Read More

Int Ophthalmol 2022 Jun 11;42(6):1927-1938. Epub 2022 Feb 11.

State Key Laboratory of Ophthalmology, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangzhou, China.

Purpose: To explore the profile of gut microbiota and central carbon-related metabolites in patients with primary angle-closure glaucoma (PACG).

Methods: The fecal microbiotas of 30 PACG patients and 30 healthy participants were detected via 16S rRNA sequencing. Targeted liquid chromatography-mass spectrometry was used to examine serum central carbon-related metabolites. Read More

BMC Ophthalmol 2022 Feb 8;22(1):59. Epub 2022 Feb 8.

Ophthalmology Unit, DIMES, Alma Mater Studiorum, University of Bologna and S. Orsola-Malpighi Teaching Hospital, 40138, Bologna, Italy.

Background: To report a case of malignant glaucoma that developed after gonioscopy-assisted transluminal trabeculotomy (GATT).

Case Presentation: An 85-year-old male pseudophakic patient affected by pseudoexfoliative glaucoma (PEXG), unresponsive to medical glaucoma treatment, underwent uneventful GATT surgery. On the first day after surgery, the eye showed a shallow central and peripheral anterior chamber (AC) with a raised intraocular pressure (IOP) measured at 55 mmHg. Read More

Vet Med Sci 2022 05 5;8(3):1036-1048. Epub 2022 Feb 5.

Section of Pathology, Department of Clinics and Surgery, Veterinary School, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.

Objective: Gross, histopathological, and immunohistochemical characteristics of uveal melanocytic neoplasms in dogs and cats were investigated.

Samples: Thirty-two enucleated globes with uveal melanocytic neoplasms, 27 from dogs and 5 from cats, were examined.

Procedures: Morphological characteristics of uveal melanocytic neoplasms in dogs and cats were evaluated with anti-PNL2, anti-Melan-A, anti-Ki-67, anti-caspase-3, and anti-BAP1 immunomarkers. Read More

Int J Ophthalmol 2022 18;15(1):65-70. Epub 2022 Jan 18.

State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangdong Provincial Clinical Research Center for Ocular Diseases, Guangzhou 510060, Guangdong Province, China.

Aim: To assess the effectiveness of core vitrectomy-phacoemulsification-intraocular lens (IOL) implantation-capsulo-hyaloidotomy in treating phakic eye at least 1mo after the onset of malignant glaucoma.

Methods: A retrospective analysis were performed on malignant glaucoma patients treated in Zhongshan Ophthalmic Center between 2016 and 2018. Demographic and clinical data were described. Read More

Front Med (Lausanne) 2021 8;8:747720. Epub 2021 Dec 8.

State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China.

To compare the choroidal vasculature characteristics by using the choroidal vascularity index (CVI) in eyes with malignant glaucoma (MG), fellow eyes with non-MG, and eyes with uncomplicated primary angle-closure glaucoma (PACG) after trabeculectomy by spectral-domain optical coherence tomography (SD-OCT). This case-control study included 53 patients diagnosed with MG after trabeculectomy. Eyes with MG ( = 53) and the fellow eyes with non-MG ( = 50) were included. Read More

Indian J Ophthalmol 2022 01;70(1):341-342

Cataract, Glaucoma, and Refractive Surgery, ASG Eye Hospital, Kolkata, West Bengal, India.

Int J Ophthalmol 2021 18;14(12):1988-1992. Epub 2021 Dec 18.

Shaanxi Eye Hospital, Xi'an People's Hospital (Xi'an Fourth Hospital), Affiliated Guangren Hospital, School of Medicine, Xi'an Jiaotong University, Xi'an 710004, Shaanxi Province, China.

Front Med (Lausanne) 2021 3;8:772578. Epub 2021 Nov 3.

State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China.

The purpose of this study was to analyze the ocular biometric parameters of primary angle-closure disease (PACD) in younger patients and compare them with those of elderly patients. This clinic-based, cross-sectional study included 154 eyes of 154 patients with PACD, consisting of 77 eyes of patients aged 40 years or younger and 77 eyes of patients older than 40. The PACD case definition was compatible with the ISGEO definition. Read More

Ann Palliat Med 2021 10;10(10):11226-11231

Department of Hematology, The Fourth Hospital of Hebei Medical University, Shijiazhuang, China.

Primary pancreatic lymphoma (PPL) is an extremely rare malignant tumor that accounts for less than 2% of extranodal malignant lymphomas and 0.5% of pancreatic tumors. The most common symptoms of PPL are abdominal pain (83%), abdominal mass (58%), and weight loss (50%). Read More

Middle East Afr J Ophthalmol 2021 Apr-Jun;28(2):137-139. Epub 2021 Sep 25.

Department of Ophthalmology, College of Medicine, King Saud University, Riyadh, Saudi Arabia.

In aqueous misdirection, the interval between diagnosis and surgical intervention is inversely proportional to the success of the surgery. Here, we report a successful outcome of pars plana vitrectomy (PPV) with irido-zonulo-hyaloidectomy 4 years after the onset of the disease. A 34-year-old female, known to have primary angle closure glaucoma, underwent trabeculectomy with mitomycin C in the right eye for uncontrolled intraocular pressure (IOP). Read More

J Fr Ophtalmol 2022 Feb 15;45(2):e95-e98. Epub 2021 Sep 15.

Service d'ophtalmologie, hôpital d'instruction des Armées de Begin, DHU Vision et Handicap, 69, avenue de Paris, 94160 Saint-Mandé, France.

Ophthalmic Epidemiol 2021 Aug 25:1-8. Epub 2021 Aug 25.

Department of Glaucoma, The Eye Hospital of Wenzhou Medical University, Zhejiang Eye Hospital, Wenzhou, Zhejiang Province, China.

Purpose: To summarize the design and methodology of a trial designed to evaluate the efficacy and safety of low dose laser cycloplasty (LCP) in treating malignant glaucoma.

Methods: Prospective, multicentre, non-controlled clinical trial. Subjects were recruited from eight ophthalmic centers in China. Read More

Int Ophthalmol 2022 Jan 9;42(1):35-45. Epub 2021 Aug 9.

VST Glaucoma Center, L V Prasad Eye Institute, Banjara Hills, Hyderabad, India.

Purpose: To compare the outcomes of phacoemulsification with phacotrabeculectomy in primary angle closure glaucoma (PACG) eyes with medically controlled intraocular pressure (IOP).

Methods: Prospective, randomized control trial including 33 eyes of 33 patients who underwent phacoemulsification (Phaco) and 37 eyes (37 patients) who underwent phacotrabeculectomy (PT). The primary outcome measure was survival defined as IOP control (IOP ≥ 6 and ≤ 21 mmHg without antiglaucoma medications (AGM) at different time points. Read More

Am J Ophthalmol Case Rep 2021 Sep 22;23:101173. Epub 2021 Jul 22.

Department of Ophthalmology, University of Washington, Seattle, WA, USA.

Purpose: To describe two cases of medium-sized uveal melanoma presenting with hemorrhagic choroidal detachments.

Observations: The first case is a 39-year-old man who presented with choroidal hemorrhage and angle closure glaucoma. The second case is a 42-year-old man who presented with choroidal hemorrhage and posterior scleritis. Read More

J Glaucoma 2021 10;30(10):895-901

State Key Laboratory of Ophthalmology, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Zhongshan Ophthalmic Center.

Background: Few studies have investigated the epidemiology of secondary glaucoma (SG) in China. This study analyzed the current profile of admitted patients with SG at the largest ophthalmic center in China.

Methods: SG cases were retrieved retrospectively by International Classification of Disease-10 clinical coding data from January 2010 to December 2019. Read More

Front Med (Lausanne) 2021 19;8:705864. Epub 2021 Jul 19.

State Key Laboratory of Ophthalmology, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China.

The treatment procedures of primary angle-closure glaucoma (PACG) with extensive peripheral anterior synechia (PAS) is a subject of debate. This study is to investigate the clinical features of phacoemulsification (Phaco)-visco dissection in medically controlled PACG patients with PAS > 180° and evaluate the predictability of Ultrasound Biomicroscopy (UBM) parameters on postoperative intraocular pressure (IOP). 48 eyes (48 patients) with acute angle-closure glaucoma (AACG) and 30 eyes (30 patients) with chronic angle-closure glaucoma (CACG) were prospectively included. Read More

Orbit 2021 Jul 28:1-8. Epub 2021 Jul 28.

Department of Ophthalmology and Visual Sciences, Dalhousie University, Halifax, Nova Scotia, Canada.

Prostaglandin F analogs (PGAs) are considered efficacious in the first-line treatment of glaucoma. They have however been associated with a number of periocular side effects. We present a case of periocular hyperpigmentation and progression to lentigo maligna melanoma (LMM) in a patient using bimatoprost eye drops. Read More

Ophthalmol Glaucoma 2022 Jan-Feb;5(1):119-120. Epub 2021 Jul 20.

Bascom Palmer Eye Institute, Department of Ophthalmology, University of Miami Miller School of Medicine, Miami, Florida. Electronic address:

J Clin Med 2021 Jul 2;10(13). Epub 2021 Jul 2.

Laboratory of Ocular Cell Biology and Visual Science, Department of Ophthalmology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo 060-8638, Hokkaido, Japan.

To investigate the expression of vascular endothelial growth factor (VEGF)-C and vascular endothelial growth factor receptor (VEGFR)3 in the trabecular meshwork (TM) of patients with glaucoma and cultured TM cells. The expressions of VEGF-C in angle tissues collected by trabeculectomy from patients with glaucoma and non-glaucomatous choroidal malignant melanoma were analyzed by immunohistochemistry. Additionally, VEGF-C concentrations were determined in the aqueous humor of patients with glaucoma by ELISA. Read More