Search Our Scientific Publications & Authors

J Ethnopharmacol 2021 Jun 6:114312. Epub 2021 Jun 6.

School of Traditional Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou, 510006, China. Electronic address:

Ethnopharmacological Relevance: The genus Erycibe belongs to the Convolvulaceae family that contains approximately 70 species mainly distributed from tropical and subtropical Asia to north of Australia. Several Erycibe species are traditionally used in folk medicine for the treatment of various ailments, including rheumatic arthralgia, primary glaucoma, hepatopathies, and infectious and malignant diseases.

Aim Of The Review: This review aims to summarize comprehensive and updated information on traditional medicinal uses, phytochemistry, pharmacology, and toxicology of Erycibe species to provide a reference for the further research and application of the Erycibe genus. Read More

Cureus 2021 May 1;13(5):e14786. Epub 2021 May 1.

Ophthalmology, 12 de Octubre Hospital, Complutense University, Madrid, ESP.

Purpose: To report a case of vitreociliary block (VCB) six months after a laser posterior capsulotomy (LPC).

Case Report: A 25-year-old man with uveitis, retinal vasoproliferative tumor, cataract, and acute angle-closure glaucoma due to pupillary seclusion, which required laser iridotomies, implantation of an Ahmed valve, phacoemulsification, and LPC. Six months after capsulotomy, he presented a generalized flattening of the anterior chamber (AC) and ocular hypertension, with patent iridotomies. Read More

Int Ophthalmol 2021 May 31. Epub 2021 May 31.

Department of Basic Science, Islamic Azad University, Shahrekord Branch, Shahrekord, Iran.

Purpose: The present research aimed to investigate the effects of Inferior peripheral irido-capsulo-hyaloidotomy for the management of pseudophakic malignant glaucoma.

Method: Ten pseudophakic eyes with aqueous misdirection were diagnosed between September 2017 and December 2018 (10 eyes of 8 patients), which were included in the prospective consecutive case series study. Seven eyes underwent Inferior laser peripheral irido-capsulo-hyaloidotomy, and three eyes underwent pars plana vitrectomy, zonulo-capsulo-hyaloidectomy, and inferior iridectomy. Read More

Probl Sotsialnoi Gig Zdravookhranenniiai Istor Med 2021 Mar;29(2):306-312

Central Research Institute of Health Organization and Informatization of Minzdrav of Russia, 127254, Moscow, Russia.

The need for changes in the primary health care system in the Russian Federation that is based on the principles of general medical practice is without any question. But, even after more than thirty years, there is no full-fledged reform still.

The Objective: To assess the state of general medical practice in the Russian Federation to identify its strengths and weaknesses, and to determine further ways of its development. Read More

Zhonghua Yan Ke Za Zhi 2021 Apr;57(4):299-304

Shanghai Eye Disease Prevention and Treatment Center, Shanghai Eye Hospital, Shanghai Vision Health Center & Shanghai Children Myopia Institute, Division of Ophthalmology Shanghai General Hospital, Shanghai Jiao Tong University, National Clinical Research Center for Eye Diseases, Shanghai 200040, China.

Atropine is a classical drug with a wide use in clinical practice. In ophthalmology, atropine can be used for cycloplegia before optometry, and the treatment of amblyopia, iridocyclitis, malignant glaucoma, etc. In recent years, the "old drugs with new application " research and application of atropine for myopia prevention and control has become a hotspot and the efficacy of atropine has been preliminarily recognized. Read More

Ocul Oncol Pathol 2021 Mar 16;7(1):36-43. Epub 2020 Nov 16.

Department of Ophthalmology, James Cook University Hospital, Middlesbrough, United Kingdom.

Purpose: To highlight the clinical spectrum, management, and outcomes of ocular/periocular complications following high-dose external-beam radiotherapy (EBRT) for inoperable malignant maxillary sinus-involving tumors (MMST).

Methods: A retrospective, interventional case series. All patients who were diagnosed with inoperable MMST (with orbital involvement) and treated with high-dose fractionated EBRT (65 Gy in 30 fractions) at James Cook University Hospital, UK, were included. Read More

Cochrane Database Syst Rev 2021 03 23;3:CD006746. Epub 2021 Mar 23.

Centre for Public Health, Queen's University Belfast, Belfast, UK.

Background: In at least a third of primary angle closure cases, appositional angle closure persists after laser peripheral iridotomy, and further intervention may be considered. Laser peripheral iridoplasty (LPIp) can be used in treating chronic angle closure when angle closure persists after laser peripheral iridotomy. Previous reviews have found insufficient data to determine its clinical effectiveness, compared to other interventions. Read More

Eur J Ophthalmol 2021 Mar 21:11206721211000641. Epub 2021 Mar 21.

Department of Ophthalmology, National Healthcare Group Eye Institute, Tan Tock Seng Hospital, Singapore.

Purpose: To evaluate the safety and efficacy of the iStent inject device combined with phacoemulsification in Asian eyes with primary open angle glaucoma.

Methods: A retrospective study of combined phacoemulsification and iStent inject surgeries performed in a single institution from July 2017 to August 2019 on patients with co-existing cataracts and primary open angle glaucoma (POAG). Outcome measures included best-corrected visual acuity, intraocular pressure (IOP), number of glaucoma eyedrop medications, and surgical complications. Read More

Eur J Ophthalmol 2021 Mar 18:11206721211003492. Epub 2021 Mar 18.

Moorfields Eye Hospital, NHS Trust, London, UK.

Purpose: To describe a case of malignant glaucoma following insertion of a Preserflo™ MicroShunt in a patient with primary open angle glaucoma (POAG).

Design: Case report.

Case: A 46-year-old Caucasian man with medically uncontrolled POAG developed malignant glaucoma 1 day after an uncomplicated insertion of a mitomycin C (MMC) augmented Preserflo MicroShunt (PMS). Read More

Int J Surg Case Rep 2021 Feb 15;79:227-230. Epub 2021 Jan 15.

Pathology & Laboratory Medicine Department, King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia.

Introduction And Importance: Juxtapapillary retinal capillary hemangiomas (RCHs) are vascular hamartomas that occur adjacent to the optic disc. Juxtapapillary RCHs can be found as an isolated finding or in association with Von Hippel-Lindau (VHL) disease. VHL is a dominantly inherited disease that is characterized by multiple intracranial and retinal hemangioblastomas along with benign and malignant visceral tumors. Read More

Taiwan J Ophthalmol 2020 Oct-Dec;10(4):302-305. Epub 2020 Feb 14.

Department of Ophthalmology, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.

The objective of this study is to report a case of refractory malignant glaucoma post trabeculectomy in vitrectomized eye and review of previous literature in PubMed database. A 63-year-old male encountered malignant glaucoma after trabeculectomy in vitrectomized eye. We had tried vitreous tapping with peripheral iridectomy and vitreous tapping with intracameral injection of room air (Chandler procedure). Read More

Biomed Res Int 2020 17;2020:8206849. Epub 2020 Dec 17.

Department of Ophthalmology, Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, China.

The role of the IB/NF-B signaling pathway in the uveoscleral outflow pathway was investigated with IB gene silencing mediated by the 3-(dimethylamino)-1-propylamine-conjugated glycogen (DMAPA-Glyp) derivative. The IB-siRNA-loaded DMAPA-Glyp complex was transfected into the ciliary muscles of rats by intracameral injection (labeled as the DMAPA-Glyp+siRNA group). The Lipofectamine™ 2000 (Lipo)/siRNA complex and the naked siRNA were set as the controls. Read More

Int J Surg Case Rep 2021 Jan 16;78:284-287. Epub 2020 Dec 16.

Department of Thoracic Surgery, Ibn Rochd-Casablanca University Hospital, Morocco; Hassan 2 University of Casablanca, Morocco. Electronic address:

Introduction: Ectopic thyroid tissue is a rare entity, and accounts for approximately 1% of all mediastinal tumours. It is a differential diagnosis of the mediastinum tumors or metastatic deposits from an orthotopic gland, as well as other benign or malignant masses. Although most cases are asymptomatic and discovered incidently by imaging, symptoms related to tumor size and its compression of adjacent structures may also appear which necessites explorations and lead to diagnosis. Read More

World J Clin Cases 2020 Nov;8(22):5758-5764

Department of General Surgery, Shougang Hospital, Peking University, Beijing 100041, China.

Background: Ligamentoid fibromatosis is a rare borderline tumor that occurs in the muscles, fascia, and aponeurosis. It is a kind of soft tissue tumor of fibrous origin, also known as invasive fibromatosis, desmoid fibroma, neurofibromatosis, . The tumor is between benign and malignant tumors and rarely has distant metastasis. Read More

Front Chem 2020 1;8:598095. Epub 2020 Dec 1.

Natural and Medical Sciences Research Center, University of Nizwa, Nizwa, Oman.

Carbonic anhydrase-II (CA-II) is associated with glaucoma, malignant brain tumors, and renal, gastric, and pancreatic carcinomas and is mainly involved in the regulation of the bicarbonate concentration in the eyes. CA-II inhibitors can be used to reduce the intraocular pressure usually associated with glaucoma. In search of potent CA-II inhibitors, a series of quinazolinones derivatives () were synthesized and characterized by IR and NMR spectroscopy. Read More

Eur J Ophthalmol 2020 Dec 18:1120672120980686. Epub 2020 Dec 18.

Department of Ophthalmology, Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China.

Objective: The incidence and risk factors of neovascular glaucoma (NVG) secondary proliferative diabetic retinopathy (PDR) after pars plana vitrectomy (PPV) are unclear and reports in the published literature are inconsistent. Therefore, a systematic review and meta-analysis were conducted to clarify the risk factors associated with neovascular glaucoma.

Methods: PubMed, Embase, and The Cochrane Library were systematically searched without language limitations for studies related to NVG after PPV in PDR patients. Read More

BMJ Case Rep 2020 Dec 13;13(12). Epub 2020 Dec 13.

Ophthalmology, Centro Hospitalar Universitário Lisboa Central, Lisbon, Portugal.

Iris melanocytoma (IM) is a rare variant of iris nevus with distinctive clinical and histopathological features. A 66-year-old woman, with a history of right eye pigmented iris nevus, presented to us with a recent onset of visual acuity decrease in that eye. She had a melanocytic iris lesion with iridocorneal angle invasion, peripheral corneal adhesion, pupil corectopia, sectorial cataract and high intraocular pressure. Read More

J Cataract Refract Surg 2020 Nov 23. Epub 2020 Nov 23.

From the Dr Rajendra Prasad Center for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India (S. Gupta, Lakra, Beniwal, Chawla, V. Gupta); Iclinix Advanced Eye Care, New Delhi, India (Gogia).

The management of malignant glaucoma involves either anterior vitrectomy with zonulectomy and iridectomy or 3-port core pars plana vitrectomy (PPV) by retinal surgeons. The proposed modification can be performed with reasonable success rates. In this technique, synechiolysis and anterior chamber irrigation is performed through a limbal incision, and a single-port 23- or 25-gauge vitrector is introduced through PPV superotemporally to perform anterior vitrectomy and central posterior capsulotomy in pseudophakic eyes. Read More

Br J Ophthalmol 2020 Nov 26. Epub 2020 Nov 26.

State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China

Purpose: To estimate the disease burden due to intraocular foreign bodies (IOFBs) and evaluate contributions of various risk factors to IOFB-associated disability-adjusted life-years (DALYs).

Methods: Global, regional and country-level number, rate and age-standardised rate of DALYs due to IOFBs were acquired from the Global Burden of Disease Study 2017 database. The Human Development Index (HDI) and other region and country-level data were obtained from open databases. Read More

Cureus 2020 Sep 26;12(9):e10672. Epub 2020 Sep 26.

Internal Medicine, Creighton University, Omaha, USA.

Introduction Retinoblastoma (Rb) is the most common intraocular malignant tumor of childhood. The different modes of Rb presentation comprise proptosis, anterior chamber inflammatory signs, spontaneous hyphema, secondary glaucoma, and strabismus. The primary aim of this study was to investigate the different clinical presentations and stages of Rb that may help in early detection and timely diagnosis to prevent the advancement of the disease and increase rates of survival in children. Read More

Cesk Slov Oftalmol 2020 ;76(2):62-67

Purpose: Eye globe enucleation due to other than a malignant tumor is very rare today. Solitary intraocular neurofibroma without other signs of neurofibromatosis is a rare benign tumor and few cases have been reported to date.

Material And Methods: In 10 year interval from Jan 1 2007 to Dec 31 2016 we analyzed non-malignant eye globe enucleations. Read More

Vet Ophthalmol 2020 Nov 21;23(6):987-993. Epub 2020 Oct 21.

College of Veterinary Medicine, Department of Clinical Sciences, Cornell University, Ithaca, NY, USA.

Objective: To describe clinical features of dogs diagnosed with choroidal melanocytic tumors at a veterinary teaching hospital.

Animals Studied: Retrospective case series of 13 dogs (14 melanocytic tumors) with choroidal melanocytic tumors.

Procedures: Medical records of dogs evaluated by the Cornell University ophthalmology service with a clinical diagnosis of a choroidal melanocytic tumor between 2008 and 2020 were reviewed. Read More

Clin Ophthalmol 2020 24;14:2799-2806. Epub 2020 Sep 24.

Department of Ophthalmology, Osaka Medical College, Takatsuki, Japan.

Purpose: To review clinical characteristics of ocular inflammation patients in Osaka, Japan, over 20 years and investigate the efficacy of required surgeries.

Methods: We conducted a retrospective study involving 2730 eyes of 1815 patients with ocular inflammation examined at the Osaka Medical College Hospital from April 1999 to March 2019.

Results: Patients comprised 843 males and 972 females, with a mean age of 56. Read More

Acta Ophthalmol 2021 May 25;99(3):251-259. Epub 2020 Aug 25.

Department of Ophthalmology, Rigshospitalet-Glostrup, Glostrup, Denmark.

Purpose: To evaluate the efficacy of vitrectomy combined with hyaloido-zonula-iridectomy from an anterior or a posterior approach in patients with treatment-resistant aqueous misdirection (chronic aqueous misdirection) by systematically reviewing existing literature in combination with presentation of a case series.

Methods: A systematic literature review was performed in PubMed, EMBASE and Cochrane Library databases using search terms: malignant glaucoma, ciliary block, ciliolenticular block and aqueous misdirection. A consecutive series of three pseudophakic patients (5 eyes) diagnosed with chronic aqueous misdirection after cataract surgery is presented. Read More

Acta Ophthalmol 2021 May 24;99(3):e330-e335. Epub 2020 Aug 24.

State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China.

Purpose: To evaluate the disease burden of age-related macular degeneration (AMD) and to evaluate the risk factors of disability-adjusted life years (DALY) caused by AMD.

Methods: Country-specific DALY number, rate and age-standardized rate of AMD were acquired from the Global Burden of Disease Study 2017 database. The Socio-demographic Index (SDI), Human Development Index (HDI), Inequality-adjusted Human Development Index (IA-HDI) and other related data were obtained from published data or shared databases. Read More

Curr Pharm Des 2020 ;26(41):5335-5346

Department of Biochemistry and Molecular Biology, College of Medical Science, China Three Gorges University, Yichang 443002, China.

Background: In view of the roles of long non-coding RNA CDKN2B antisense RNA 1 (CDKN2BAS1) in various human diseases, we investigated the function of CDKN2B-AS1 and explored its therapeutic and prognostic target value in multiple biological processes. The aim of this review was to explore the molecular mechanism and clinical significance of CDKN2B-AS1 in various types of diseases.

Materials And Methods: In this review, the biological functions and mechanisms of lncRNA CDKN2B-AS1 in a variety of pathophysiological processes were summarized and analyzed. Read More

J Cancer 2020 19;11(16):4652-4661. Epub 2020 May 19.

King Abdullah International Medical Research Center (KAIMRC)/ King Saud Bin Abdulaziz University for Health Sciences (KSAU-HS), MNGHA, Saudi Arabia.

Glaucoma is a serious disease that can lead to irreversible loss of vision. Patients with primary congenital glaucoma may have elevated intraocular pressure. Hypertension causes damages to intraocular structures and affects the Schlemm's canal, collector channels, trabecular meshwork, and optic nerve's molecular structures. Read More

BMC Ophthalmol 2020 Jun 9;20(1):222. Epub 2020 Jun 9.

Guangdong Hospital of Traditional Chinese Medicine, Zhuhai, China.

Background: To investigate the safety and efficacy of scleral concave pool trabeculectomy (SCPT) combined phacoemulsification for eyes with coexisting cataract and primary open-angle glaucoma (POAG).

Methods: This was a retrospective, controlled, interventional pilot case series. Thirty patients (30 eyes) were diagnosed with coexisting cataract and POAG between May 2015 and April 2018. Read More

Ophthalmologe 2021 Apr;118(4):391-393

Augenärztliches Operationszentrum Fulda, Fulda, Hessen, Deutschland.

Malignant glaucoma describes a rare constellation with shallowing of the anterior chamber and raised intraocular pressure, which can occur after ocular surgery, trauma or spontaneously. The pathophysiological mechanism seems to consist of a posteriorly directed flow of the aqueous humor formed in the ciliary body into or behind the vitreous body. Most cases can only be treated by surgical intervention. Read More

Ophthalmologe 2021 Feb;118(2):175-179

Klinik für Augenheilkunde, Universitätsklinikum Freiburg, Universitätsklinikum Freiburg, Killianstr. 5, 79106, Freiburg, Deutschland.

The occurrence of malignant glaucoma several years after cataract surgery is a very rare delayed complication. An increasing myopic shift can be an early hint for the formation. A surgical intervention is often inevitable; however, intraocular pressure can also be successfully managed with conservative treatment as in the case described. Read More