721 results match your criteria Glaucoma Malignant


Scleral concave pool trabeculectomy combined phacoemulsification in primary open-angle glaucoma with cataract.

BMC Ophthalmol 2020 Jun 9;20(1):222. Epub 2020 Jun 9.

Guangdong Hospital of Traditional Chinese Medicine, Zhuhai, China.

Background: To investigate the safety and efficacy of scleral concave pool trabeculectomy (SCPT) combined phacoemulsification for eyes with coexisting cataract and primary open-angle glaucoma (POAG).

Methods: This was a retrospective, controlled, interventional pilot case series. Thirty patients (30 eyes) were diagnosed with coexisting cataract and POAG between May 2015 and April 2018. Read More

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http://dx.doi.org/10.1186/s12886-020-01500-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7285585PMC
June 2020
1.075 Impact Factor

[Bilateral postoperative myopic shift and rise in intraocular pressure after cataract surgery].

Ophthalmologe 2020 May 19. Epub 2020 May 19.

Augenärztliches Operationszentrum Fulda, Fulda, Hessen, Deutschland.

Malignant glaucoma describes a rare constellation with shallowing of the anterior chamber and raised intraocular pressure, which can occur after ocular surgery, trauma or spontaneously. The pathophysiological mechanism seems to consist of a posteriorly directed flow of the aqueous humor formed in the ciliary body into or behind the vitreous body. Most cases can only be treated by surgical intervention. Read More

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http://dx.doi.org/10.1007/s00347-020-01123-4DOI Listing

[Chronification of malignant glaucoma after cataract surgery].

Ophthalmologe 2020 Apr 1. Epub 2020 Apr 1.

Klinik für Augenheilkunde, Universitätsklinikum Freiburg, Universitätsklinikum Freiburg, Killianstr. 5, 79106, Freiburg, Deutschland.

The occurrence of malignant glaucoma several years after cataract surgery is a very rare delayed complication. An increasing myopic shift can be an early hint for the formation. A surgical intervention is often inevitable; however, intraocular pressure can also be successfully managed with conservative treatment as in the case described. Read More

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http://dx.doi.org/10.1007/s00347-020-01088-4DOI Listing

Naevus of Ota: clinical characteristics and proposal for a new ocular classification and grading system.

Br J Ophthalmol 2020 Mar 30. Epub 2020 Mar 30.

Goldschleger Eye Institute, Sheba Medical Center, Tel Hashomer, affiliated to the Sackler Faculty of Medicine, Tel Aviv University, Tel Hashomer, Israel.

Introduction: Naevus of Ota is a congenital condition that may involve the skin, eyeball and even intracranial structures usually in the distribution of the ophthalmic and maxillary divisions of the trigeminal cranial nerve. The purpose of this study was to summarise our experience with the ocular clinical presentation, imaging, outcome, treatment of complications and to offer a new classification of patients with naevus of Ota.

Methods: We retrospectively reviewed the patients' medical records and the following parameters were retrieved and analysed: demographics, clinical presentation complications and treatment of complications. Read More

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http://dx.doi.org/10.1136/bjophthalmol-2019-313984DOI Listing

Retinal Pigment Epithelium Cell Density and Bruch's Membrane Thickness in Secondary versus Primary High Myopia and Emmetropia.

Sci Rep 2020 Mar 20;10(1):5159. Epub 2020 Mar 20.

Augenpraxis Jonas, Heidelberg, Germany.

To assess differences between secondary high myopia (SHM) due to congenital glaucoma and primary high myopia (PHM) and non-highly myopic eyes (NHM) in the relationships between axial length and Bruch's membrane (BM) thickness and retinal pigment epithelium (RPE) density. The histomorphometric study included human globes enucleated for reasons such as malignant uveal melanoma, end-stage painful secondary angle-closure glaucoma and congenital glaucoma. BM thickness and RPE cell density were measured upon light microscopy. Read More

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http://dx.doi.org/10.1038/s41598-020-62096-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7083925PMC

Histology of myopic posterior scleral staphylomas.

Acta Ophthalmol 2020 Mar 19. Epub 2020 Mar 19.

Department of Ophthalmology, Medical Faculty Mannheim of the Ruprecht-Karls-University of Heidelberg, Mannheim, Germany.

Purpose: Since histomorphometric descriptions of posterior scleral staphylomas, although forming a major part of myopic maculopathy, have been scarce so far, we histomorphometrically examined scleral staphylomas in enucleated human eyes.

Methods: Using light microscopy, we histomorphometrically examined sagittal histological sections of human globes enucleated due to malignant choroidal melanomas or secondary angle-closure glaucoma.

Results: Out of 246 globes included into the study, posterior scleral staphylomas were detected in 10 eyes (mean length: 31. Read More

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http://dx.doi.org/10.1111/aos.14405DOI Listing

Intraoperative injection versus sponge-applied mitomycin C during trabeculectomy: One-year study.

Indian J Ophthalmol 2020 04;68(4):615-619

Department of Glaucoma, Aravind Eye Hospital and Post Graduate Institute of Ophthalmology, Tirunelveli, Tamil Nadu, India.

Purpose: To determine the safety and efficacy of mitomycin C (MMC) injection versus sponge during trabeculectomy.

Methods: It is a prospective analysis of patients who underwent trabeculectomy with MMC and followed up for 1 year, divided into two groups, namely, group 1- injection (n = 21), group 2-> sponge (n = 21). The same concentration of MMC was used for both groups. Read More

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http://dx.doi.org/10.4103/ijo.IJO_963_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7210852PMC

Evening exercise is associated with lower odds of visual field progression in Chinese patients with primary open angle glaucoma.

Eye Vis (Lond) 2020 1;7:12. Epub 2020 Mar 1.

2School of Ophthalmology and Optometry, Eye Hospital, Wenzhou Medical University, No. 270, Xue Yuan Xi Road, Wenzhou, 3250027 Zhejiang China.

Background: Exercise is widely known to lower intraocular pressure and increase ocular blood flow, which may be beneficial for glaucoma management. However, there are few studies that have reported on the relationship between exercise and glaucoma progression. The aim of our study was to investigate the exercise habits of those with primary open angle glaucoma (POAG) and its association with the progression of visual field (VF) loss. Read More

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http://dx.doi.org/10.1186/s40662-020-0175-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7049389PMC

Slit-lamp Pars Plana Needle Hyaloidotomy-Zonulotomy-Iridotomy for the Treatment of Spontaneous Malignant Glaucoma.

J Glaucoma 2020 May;29(5):e31-e32

Department of Ophthalmology and Visual Sciences, Kellogg Eye Center, University of Michigan, Ann Arbor, MI.

An 88-year-old woman with a history of recent complicated pacemaker insertion presented with acute-onset malignant glaucoma recalcitrant to conservative medical therapy. Surgical intervention was discussed; however, given her complex cardiac history and recent postoperative state, the risk of anesthesia-related systemic adverse events was deemed unacceptably high. As such, a slit-lamp procedure was recommended to break the attack of malignant glaucoma. Read More

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http://dx.doi.org/10.1097/IJG.0000000000001473DOI Listing

Survey of 138 Conjunctival Tumors in the Dominican Republic.

Ophthalmic Epidemiol 2020 Aug 17;27(4):278-282. Epub 2020 Feb 17.

Ocular Pathology Laboratory, Laboratorio de Patología Ocular Dr. Gerson Vizcaíno López , Santo Domingo, Dominican Republic.

Purpose: To report the frequency of conjunctival tumors in the Dominican Republic.

Methods: Retrospective noninterventional case series. One hundred thirty-eight consecutive patients with a conjunctival mass evaluated at two tertiary referral centers from 2010 to 2018. Read More

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http://dx.doi.org/10.1080/09286586.2020.1730912DOI Listing

One-year outcome of low dose laser cyclophotocoagulation for capsular tension ring-induced malignant glaucoma: A case report.

Medicine (Baltimore) 2020 Feb;99(6):e18836

The Eye Hospital of Wenzhou Medical University, Zhejiang Eye Hospital.

Rationale: Malignant glaucoma is a refractory glaucoma which often relentlessly worsened despite conventional therapy. Ultrasonographic biomicroscopy always cannot show the ciliary-block of malignant glaucoma. We report a case of capsular tension ring induced ciliary-block and successfully treated by low dose laser cyclophotocoagulation, with 1-year follow-up. Read More

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http://dx.doi.org/10.1097/MD.0000000000018836DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7015563PMC
February 2020

Spontaneous malignant glaucoma: Case report and review of the literature.

Saudi J Ophthalmol 2019 Oct-Dec;33(4):398-400. Epub 2018 Dec 7.

Ophthalmology Department, University Hospital Ramón y Cajal, Madrid, Spain.

Malignant glaucoma usually occurs after anterior segment surgery (typically after glaucoma surgery). The aim of this article is to report a case of spontaneous malignant glaucoma (SpMG), which required phacovitrectomy for resolution and to review the cases of SpMG reported in modern literature. Only nine cases were identified. Read More

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http://dx.doi.org/10.1016/j.sjopt.2018.11.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6950959PMC
December 2018

Gut microbiota compositional profile and serum metabolic phenotype in patients with primary open-angle glaucoma.

Exp Eye Res 2020 Feb 7;191:107921. Epub 2020 Jan 7.

State Key Laboratory of Ophthalmology, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China. Electronic address:

The gut microbiota (GM) and its influence on host metabolism are considered to be an environmental factor that contributes to the progression of many immune and neurodegenerative diseases. However, the features of the GM and serum metabolites in Primary open-angle glaucoma (POAG) patients have not been clearly elucidated. The purpose of this research is to explore the gut microbial composition and serum metabolic phenotype in POAG patients. Read More

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http://dx.doi.org/10.1016/j.exer.2020.107921DOI Listing
February 2020

Properties of FDA-approved small molecule protein kinase inhibitors: A 2020 update.

Authors:
Robert Roskoski

Pharmacol Res 2020 02 17;152:104609. Epub 2019 Dec 17.

Blue Ridge Institute for Medical Research, 3754 Brevard Road, Suite 116, Box 19, Horse Shoe, North Carolina, 28742-8814, United States. Electronic address:

Because genetic alterations including mutations, overexpression, translocations, and dysregulation of protein kinases are involved in the pathogenesis of many illnesses, this enzyme family is currently the subject of many drug discovery programs in the pharmaceutical industry. The US FDA approved four small molecule protein kinase antagonists in 2019; these include entrectinib, erdafitinib, pexidartinib, and fedratinib. Entrectinib binds to TRKA/B/C and ROS1 and is prescribed for the treatment of solid tumors with NTRK fusion proteins and for ROS1-postive non-small cell lung cancers. Read More

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http://dx.doi.org/10.1016/j.phrs.2019.104609DOI Listing
February 2020

Time trends and heterogeneity in the disease burden of glaucoma, 1990-2017: a global analysis.

J Glob Health 2019 Dec;9(2):020436

Department of Ophthalmology, Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.

Background: To evaluate the disease burden of glaucoma in terms of disability-adjusted life years (DALY) and assess the contribution of risk factors to DALY due to glaucoma.

Methods: Global, regional, and country DALY number, rate, and age-standardized rates of glaucoma were obtained from the Global Burden of Disease Study 2017 database. The Human Development Index (HDI), Inequality-Adjusted HDI, Socio-Demographic Index (SDI), and other country-level data were derived from international open databases. Read More

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http://dx.doi.org/10.7189/jogh.09.020436DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6875680PMC
December 2019

Intravitreous Cutaneous Metastatic Melanoma in the Era of Checkpoint Inhibition: Unmasking and Masquerading.

Ophthalmology 2020 02 24;127(2):240-248. Epub 2019 Sep 24.

Department of Ophthalmology, Emory University School of Medicine, Atlanta, Georgia.

Purpose: Cutaneous melanoma metastatic to the vitreous is very rare. This study investigated the clinical findings, treatment, and outcome of patients with metastatic cutaneous melanoma to the vitreous. Most patients received checkpoint inhibition for the treatment of systemic disease, and the significance of this was explored. Read More

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http://dx.doi.org/10.1016/j.ophtha.2019.09.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7003537PMC
February 2020

Unusual complications and corneal clearance after Descemet Membrane Endothelial Transfer in Pseudophakic Bullous Keratopathy.

Rom J Ophthalmol 2019 Jul-Sep;63(3):277-280

Ophthalmology Department, Hospital Regional Universitario de Málaga, Spain.

to report malignant glaucoma and infectious crystalline keratopathy as complications after an uneventful Descemet Membrane Endothelial Keratoplasty (DMEK), and corneal clearance despite graft detachment after the surgery in a patient with pseudophakic bullous keratopathy. A 81-year-old patient with high Intraocular Pressure (IOP) and flat anterior chamber with patent iridotomies after DMEK was diagnosed of malignant glaucoma. The medical approach being insufficient, the patient required a pars-plana vitrectomy, capsulo-hyaloidectomy, and surgical iridectomy. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6820491PMC
December 2019

Pseudophakic malignant glaucoma - a case report.

Rom J Ophthalmol 2019 Jul-Sep;63(3):268-272

Department of Ophthalmology, University of Medicine and Pharmacy of Craiova, Romania.

To report a case of malignant glaucoma in a pseudophakic female patient, with no history of glaucoma, resolved through pars plana anterior vitrectomy. An 80-year-old female patient presented in our Emergency Department after a five-day history of pain in her left eye (LE). In the last day, the patient noticed marked visual loss and ocular pain. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6820490PMC
December 2019

Comment on: Factors Impacting Outcomes and the Time to Recovery from Malignant Glaucoma.

Am J Ophthalmol 2020 01 25;209:214-215. Epub 2019 Oct 25.

Gdańsk, Poland.

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http://dx.doi.org/10.1016/j.ajo.2019.08.028DOI Listing
January 2020
1 Read

Genomic Prediction of 16 Complex Disease Risks Including Heart Attack, Diabetes, Breast and Prostate Cancer.

Sci Rep 2019 10 25;9(1):15286. Epub 2019 Oct 25.

Department of Physics and Astronomy, Michigan State University, East Lansing, Michigan, USA.

We construct risk predictors using polygenic scores (PGS) computed from common Single Nucleotide Polymorphisms (SNPs) for a number of complex disease conditions, using L1-penalized regression (also known as LASSO) on case-control data from UK Biobank. Among the disease conditions studied are Hypothyroidism, (Resistant) Hypertension, Type 1 and 2 Diabetes, Breast Cancer, Prostate Cancer, Testicular Cancer, Gallstones, Glaucoma, Gout, Atrial Fibrillation, High Cholesterol, Asthma, Basal Cell Carcinoma, Malignant Melanoma, and Heart Attack. We obtain values for the area under the receiver operating characteristic curves (AUC) in the range ~0. Read More

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http://dx.doi.org/10.1038/s41598-019-51258-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6814833PMC
October 2019
4 Reads

Unilateral Malignant Glaucoma Postbilateral Implantable Collamer Lens: Effect of Miotics.

Middle East Afr J Ophthalmol 2019 Jul-Sep;26(3):181-183. Epub 2019 Sep 30.

Department of Cornea and Refractive Surgery, Beirut Eye and ENT Specialist Hospital, Beirut, Lebanon.

An implantable collamer lens (ICL) V4c model (STAAR Surgical, Monrovia, CA, USA) was placed in the eye of a 31-year-old male patient with high myopia followed by the development of malignant glaucoma. After failing medical treatment for 5 days, a noncomplicated pars plana vitrectomy and anterior hyaloidectomy succeeded in breaking the aqueous misdirection. Sixteen months later, intraoperative miotics were purposefully withheld from the ICL surgery in the fellow eye and malignant glaucoma did not develop. Read More

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http://dx.doi.org/10.4103/meajo.MEAJO_197_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6788314PMC
January 2020
1 Read

Treatment outcomes and efficacy of pars plana vitrectomy-hyaloidotomy-zonulectomy-iridotomy in malignant glaucoma.

Eur J Ophthalmol 2019 Oct 7:1120672119877139. Epub 2019 Oct 7.

Glaucoma Services, Advanced Eye Centre, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.

Aim: To study the treatment outcomes and efficacy of pars plana vitrectomy-hyaloidotomy-zonulectomy-iridotomy in malignant glaucoma.

Method: A retrospective case series study of patients treated for malignant glaucoma between 2005 and 2017. The treatment included medical management as first-line in the form of cycloplegic with anti-glaucoma medications (AGM) or pars plana vitrectomy-hyaloidotomy-zonulectomy-iridotomy as second-line therapy. Read More

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http://dx.doi.org/10.1177/1120672119877139DOI Listing
October 2019

A new paradigm for delivering personalised care: integrating genetics with surgical interventions in BEST1 mutations.

Eye (Lond) 2020 Mar 27;34(3):577-583. Epub 2019 Aug 27.

Imperial College NHS Foundation Trust, London, UK.

Background: The availability and reduced cost of genotyping has improved gene susceptibility testing and our scientific understanding of disease pathophysiology. Whilst several personalised translational models exist within medical frameworks, genetic-based surgical therapy is a translational application not widely used in surgical specialties.

Method: We present a clinical series of five patients with genetically confirmed bestrophinopathy and malignant glaucoma (MG). Read More

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http://dx.doi.org/10.1038/s41433-019-0553-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7042240PMC
March 2020
3 Reads

In Reply: Fluid Misdirection Syndrome: The Unified Definition of Malignant Glaucoma.

J Glaucoma 2019 11;28(11):e165

Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Palm Beach Gardens, FL.

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http://dx.doi.org/10.1097/IJG.0000000000001338DOI Listing
November 2019
2 Reads

Chronic fluid misdirection syndrome of aqueous humor after phacoemulsification: diagnosis, treatment and asscociated factors.

Arch Soc Esp Oftalmol 2019 Oct 2;94(10):491-494. Epub 2019 Aug 2.

Unidad de Gestión Clínica de Oftalmología, Hospital Universitario San Cecilio, Granada, España.

The chronic fluid misdirection syndrome of aqueous humor is a rare and serious condition if not treated promptly. The case is presented of a woman attending the emergency department with an intraocular pressure of 43.00mmHg and shallow anterior chamber in her left eye. Read More

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http://dx.doi.org/10.1016/j.oftal.2019.05.015DOI Listing
October 2019
1 Read

Factors Impacting Outcomes and the Time to Recovery From Malignant Glaucoma.

Am J Ophthalmol 2020 01 1;209:141-150. Epub 2019 Aug 1.

Department of Ophthalmology, Duke University, Durham, North Carolina, USA. Electronic address:

Purpose: To identify factors associated with the successful treatment of malignant glaucoma (MG).

Design: Retrospective case series.

Methods: Setting: single institution; study population: 64 eyes (55 subjects) with MG; observation procedure(s): chart review; main outcome measures: anatomy, intraocular pressure (IOP), best visual acuity (BVA). Read More

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http://dx.doi.org/10.1016/j.ajo.2019.07.023DOI Listing
January 2020
4 Reads

Fluid Misdirection Syndrome: The Unified Definition of Malignant Glaucoma.

J Glaucoma 2019 11;28(11):e165

Department of Ophthalmology, University of Warmia and Mazury, Olsztyn.

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http://dx.doi.org/10.1097/IJG.0000000000001337DOI Listing
November 2019
1 Read

Ureidobenzenesulfonamides as efficient inhibitors of carbonic anhydrase II.

Bioorg Chem 2019 10 17;91:103123. Epub 2019 Jul 17.

Martin-Luther-University Halle-Wittenberg, Organic Chemistry, Kurt-Mothes-Str. 2, D-06120 Halle (Saale), Germany. Electronic address:

Sulfonamides represent an important class of drugs because of their inhibitory effect on carbonic anhydrases (CAs). We therefore synthesized several ureidobenzenesulfonamides and evaluated their bCA II inhibition for their potential use as anti-glaucoma gents. Since these compounds must not show cytotoxic effects, their cytotoxic potential against several human tumor cell lines and non-malignant fibroblasts was investigated. Read More

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http://dx.doi.org/10.1016/j.bioorg.2019.103123DOI Listing
October 2019

Epithelial downgrowth after femtosecond laser-assisted cataract surgery.

Am J Ophthalmol Case Rep 2019 Sep 2;15:100507. Epub 2019 Jul 2.

Department of Ophthalmology & Vision Science, University of California, Davis, 4860 Y Street, Suite 2400, Sacramento, CA, 95817, USA.

Purpose: To present the case of a 72-year-old female with epithelial downgrowth after femtosecond laser-assisted cataract surgery.

Observations: The patient previously underwent YAG vitreolysis after uncomplicated femtosecond laser-assisted cataract surgery and presented 1 year later with epithelial downgrowth causing complete pupillary block and severe angle closure glaucoma. Subsequent management with nd:YAG peripheral iridotomies failed rapidly leading to a confusing presentation with a flat anterior chamber and high intraocular pressure ultimately requiring surgical management. Read More

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http://dx.doi.org/10.1016/j.ajoc.2019.100507DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6616539PMC
September 2019
4 Reads

Large choroidal melanoma presenting as neovascular glaucoma.

GMS Ophthalmol Cases 2019 31;9:Doc19. Epub 2019 May 31.

Sagarmatha Choudhary Eye Hospital, Siraha, Nepal.

Choroidal melanoma is a relatively rare tumour with a poor prognosis, though it is the most common primary malignancy of the eye among adults. Choroidal melanoma has been reported to present as acute angle closure glaucoma, secondary glaucoma, chronic uveitis, cataract, and staphyloma. We report a case of a28-year-old male presenting with features of neovascular glaucoma in the right eye and having initially been treated with anti-glaucoma medications. Read More

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http://dx.doi.org/10.3205/oc000108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6607447PMC
May 2019
10 Reads

Management of Pseudophakic Malignant Glaucoma in Sunset Syndrome: A Case Report and Literature Review.

Med Hypothesis Discov Innov Ophthalmol 2019 ;8(2):92-95

Department of Ophthalmology, St. Lucas Hospital, Thessaloniki, Greece.

To present an interesting case of pseudophakic malignant glaucoma in sunset syndrome, which potentially points to a correlation between a posterior chamber intraocular lens (PCIOL) subluxation and development of aqueous misdirection. Furthermore, we underlined the effectiveness of YAG-laser hyaloidotomy as a first line treatment for malignant glaucoma. This is a case report and literature review. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6592301PMC
January 2019
5 Reads

Commentary: Malignant Glaucoma - Have we finally found an answer?

Authors:
Sushmita Kaushik

Indian J Ophthalmol 2019 07;67(7):1206-1207

Advanced Eye Centre, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

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http://dx.doi.org/10.4103/ijo.IJO_134_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6611285PMC
July 2019
4 Reads

Management of recurrent aqueous misdirection by anterior segment surgeon after failed pars plana posterior vitrectomy.

Indian J Ophthalmol 2019 07;67(7):1204-1206

Department of Cornea, Centre for Sight, Road No 2, Banjara Hills, Hyderabad, Telangana, India.

Aqueous misdirection (AM) is a dreaded complication, but fortunately quite rare. It usually occurs after intervention for angle closure glaucoma. When pharmacotherapy and/or laser interventions are unsuccessful, then the surgical management hitherto most commonly undertaken is pars plana posterior vitrectomy. Read More

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http://dx.doi.org/10.4103/ijo.IJO_1430_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6611260PMC
July 2019
6 Reads

Intra-Operative Ostial Irido-Zonulo-Hyaloido-Vitrectomy with Primary Posterior Capsulectomy for Prevention of Post-Operative Aqueous Misdirection in Combined Phaco-Trabeculectomy in Primary Angle Closure Glaucoma.

Curr Eye Res 2019 10 14;44(10):1087-1090. Epub 2019 Jun 14.

L V Prasad Eye Institute , Hyderabad , India.

: The aim of this study is to investigate the ability of ostial irido-zonulo-hyaloido-vitrectomy (ostial IZHV) with primary posterior capsulectomy (PPC) in preventing aqueous misdirection (AM) in combined cataract and filtration surgery in a high-risk group of angle closure disease. : Comparative case series-data collection of consecutive adult subjects (>18 years) with angle closure, undergoing phaco-trabeculectomy, when per-operatively anterior chamber depth (ACD) remained shallow, putting them at high risk for development of AM post-operatively. Study subjects were compared to controls, who also underwent combined surgery in angle closure, but did not have shallow AC per-operatively, in the study period of January 2012 to December 2016. Read More

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http://dx.doi.org/10.1080/02713683.2019.1625409DOI Listing
October 2019
5 Reads

Intraocular medulloepithelioma - A review of clinical features, DICER 1 mutation, and management.

Indian J Ophthalmol 2019 06;67(6):755-762

Department of Ocular Oncology, Centre for Sight, Hyderabad, Telangana, India.

Intraocular medulloepithelioma is a nonhereditary neoplasm of childhood arising from primitive medullary epithelium. It most often involves the ciliary body. Most patients present between 2 and 10 years of age with loss of vision, pain, leucocoria, or conjunctival congestion. Read More

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http://dx.doi.org/10.4103/ijo.IJO_845_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6552580PMC
June 2019
23 Reads

Anterior Segment Features in Nanophthalmos With Secondary Chronic Angle Closure Glaucoma: An Ultrasound Biomicroscopy Study.

Invest Ophthalmol Vis Sci 2019 05;60(6):2248-2256

State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China.

Purpose: We compare anterior segment parameters and the risk of malignant glaucoma between nanophthalmos with secondary chronic angle closure glaucoma (NSCACG) and chronic primary angle-closure glaucoma (CPACG).

Methods: This retrospective case-control study included 32 NSCACG (32 eyes) and 36 CPACG (36 eyes) patients. Anterior segment parameters, including anterior chamber depth (ACD) and width (ACW), pupil diameter (PD), lens vault (LV), ciliary process-ciliary process distance (CCD), angle opening distance500 (AOD500), trabecular-iris angle (TIA), trabecular-ciliary processes distance (TCPD), ciliary body max thickness (CBMT), iris convexity (IC), peripheral iris thickness (PIT), iris-zonule distance (IZD), trabecular ciliary process angle (TCPA), and anterior vault (AV), were measured by ultrasound biomicroscopy. Read More

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http://iovs.arvojournals.org/article.aspx?doi=10.1167/iovs.1
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http://dx.doi.org/10.1167/iovs.19-26867DOI Listing
May 2019
22 Reads

Conservative management of suspicious melanocytic lesions of the iris.

Graefes Arch Clin Exp Ophthalmol 2019 Jun 27;257(6):1319-1324. Epub 2019 Mar 27.

Ocular Melanoma Center, Retina Service, Mass Eye and Ear, 243 Charles Street., Boston, MA, 02114, USA.

Purpose: The diagnosis of iris melanoma can be difficult, with no established diagnostic criteria currently available. Careful monitoring of patients with suspicious iris lesions is one approach to managing these tumors. We determined the risk of malignant transformation and melanoma-related mortality in patients under observation to evaluate the validity of this management approach. Read More

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http://dx.doi.org/10.1007/s00417-019-04296-0DOI Listing
June 2019
19 Reads

Proton radiotherapy in advanced malignant melanoma of the conjunctiva.

Graefes Arch Clin Exp Ophthalmol 2019 Jun 27;257(6):1309-1318. Epub 2019 Mar 27.

Department of Radiation Therapy, University Hospital Essen, Hufelandstrasse 55, 45147, Essen, Germany.

Background: The management of conjunctival melanoma is challenging and frequently ends in exenteration. The aim of this retrospective study was to evaluate the long-term results of proton beam radiation with regard to various clinical parameters.

Methods: Eighty-nine patients with extended conjunctival melanoma (≥T2) and multifocal bulbar located tumors (T1c/d) were treated consecutively with proton radiotherapy (dose 45 Gy). Read More

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http://dx.doi.org/10.1007/s00417-019-04286-2DOI Listing
June 2019
9 Reads

Vitreous concentrations of vascular endothelial growth factor as a potential biomarker for postoperative complications following pars plana vitrectomy.

Arch Med Sci 2019 Mar 2;15(2):449-456. Epub 2018 Feb 2.

School of Medicine, University of Sarajevo, Sarajevo, Bosnia and Herzegovina.

Introduction: The aim of the study was to investigate the effects of vascular endothelial growth factor (VEGF) concentration in vitreous on postoperative complications after pars plana vitrectomy (PPV).

Material And Methods: Ninety subjects were surgically treated with PPV and followed up for 12 months at the Clinical Centre University Sarajevo, Clinic for Eye Disease. Exclusion criteria were presence of other eye diseases, systemic acute/chronic inflammatory conditions, or malignant neoplasms; previously performed PPV surgery; previously received intravitreal or systemic anti-VEGF therapy. Read More

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http://dx.doi.org/10.5114/aoms.2018.73208DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425199PMC
March 2019
11 Reads

Romanian ophthalmologists in the renowned ophthalmic journals worldwide.

Rom J Ophthalmol 2018 Oct-Dec;62(4):260-269

OcuCenter Ophthalmological Clinic, Cluj-Napoca, Romania.

The authors are discussing over 80 articles that they have published in the last 5 years in the renowned ophthalmic journals worldwide, which have approached, for the first time in the ophthalmic literature, the following 4 topics: the acute central/ hemicentral retinal vein occlusion, the therapeutic interventions in the fellow eye of patients with unilateral malignant glaucoma, the persistent diabetic macular edema, and the current researches in patients with neovascular age-related macular degeneration. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421486PMC
April 2019
10 Reads

[XEN Gel Stent for management of chronic open angle glaucoma: A review of the literature (French translation of the article)].

J Fr Ophtalmol 2019 Apr 14;42(4):391-403. Epub 2019 Mar 14.

Service d'ophtalmologie, centre hospitalier national d'ophtalmologie des Quinze-Vingts, 28, rue de Charenton, 75012 Paris, France; Service d'ophtalmologie, université de Versailles Saint-Quentin-en-Yvelines, hôpital Ambroise-Paré, AP-HP, 9, avenue Charles-De-Gaulle, 92100 Boulogne Billancourt, France; Inserm, U968, université UPMC Paris VI, UMR S 968, institut de la vision , CNRS, UMR 7210, 75012 Paris, France. Electronic address:

Purpose: The purpose of this study was to analyze the change in intraocular pressure (IOP) and glaucoma medications using the XEN Gel Stent as a solo procedure or in association with phacoemulsification in patients with chronic open angle glaucoma (OAG).

Methods: We included cohort studies with at least one year of follow-up in patients with primary open angle glaucoma (POAG), pseudo-exfoliative glaucoma (PXG) or pigmentary glaucoma (PG) who received a XEN® gel stent. The main outcome measure was IOP reduction at 12 months follow-up. Read More

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http://dx.doi.org/10.1016/j.jfo.2018.10.005DOI Listing
April 2019
9 Reads

Properties of FDA-approved small molecule protein kinase inhibitors.

Authors:
Robert Roskoski

Pharmacol Res 2019 06 13;144:19-50. Epub 2019 Mar 13.

Blue Ridge Institute for Medical Research, 3754 Brevard Road, Suite 116, Box 19, Horse Shoe, NC 28742-8814, United States. Electronic address:

Because mutations, overexpression, and dysregulation of protein kinases play essential roles in the pathogenesis of many illnesses, this enzyme family has become one of the most important drug targets in the past 20 years. The US FDA has approved 48 small molecule protein kinase inhibitors, nearly all of which are orally effective with the exceptions of netarsudil (which is given as an eye drop) and temsirolimus (which is given intravenously). Of the 48 approved drugs, the majority (25) target receptor protein-tyrosine kinases, ten target non-receptor protein-tyrosine kinases, and 13 target protein-serine/threonine protein kinases. Read More

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http://dx.doi.org/10.1016/j.phrs.2019.03.006DOI Listing
June 2019
11 Reads

Malignant Glaucoma After Laser Peripheral Iridotomy.

J Glaucoma 2019 03;28(3):e44-e45

Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Palm Beach Gardens, FL.

Purpose: We describe a patient with primary angle-closure glaucoma who developed malignant glaucoma following laser peripheral iridotomy.

Methods: A 58-year-old male presented with peripheral and central anterior chamber shallowing following an uncomplicated Nd: YAG laser peripheral iridotomy. Intraocular pressure (IOP) and B-scan echography were normal, and there was -1. Read More

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http://dx.doi.org/10.1097/IJG.0000000000001145DOI Listing
March 2019
3 Reads

Seasonal Variation in the Incidence of Malignant Glaucoma after Cataract Surgery.

J Ophthalmic Vis Res 2019 Jan-Mar;14(1):32-37

Department of Ophthalmology and Visual Sciences, Washington University, St Louis, MO, USA.

Purpose: To investigate a potential link between the incidence of malignant glaucoma after cataract surgery and seasonal variations in daylight.

Methods: In total, 18,374 uncomplicated cataract surgeries were performed between June 2008 and June 2013 at an ambulatory surgery center in Toronto. Toronto's average monthly daylight over that time period-in hours per day for each month-was determined. Read More

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http://dx.doi.org/10.4103/jovr.jovr_41_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6388520PMC
March 2019
5 Reads

Iris varix: 10-year experience with 28 eyes.

Indian J Ophthalmol 2019 Mar;67(3):350-357

Department of Ocular Tumor, Orbital Disease and Ophthalmic Radiation Therapy, The New York Eye Cancer Center, New York City, New York, USA.

Purpose: The purpose of this study is to describe the clinical characteristics, multimodality imaging findings, and clinical course of iris varices.

Methods: Retrospective, noncomparative, observational case series of 28 eyes of 26 patients with iris varices, diagnosed between 2007 and 2017, has been used.

Results: The mean (±SD) age was 58. Read More

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http://dx.doi.org/10.4103/ijo.IJO_1253_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6407407PMC
March 2019
6 Reads

XEN Gel Stent for management of chronic open angle glaucoma: A review of the literature.

J Fr Ophtalmol 2019 Feb 22;42(2):e37-e46. Epub 2019 Jan 22.

Service d'ophtalmologie, centre hospitalier national d'ophtalmologie des Quinze-Vingts, IHU ForeSight, , 28, rue de Charenton, 75012 Paris, France; Service d'ophtalmologie, hôpital Ambroise-Paré, université de Versailles Saint-Quentin-en-Yvelines, AP-HP, 9, avenue Charles-De-Gaulle, 92100 Boulogne-Billancourt, France; Inserm, U968, université UPMC Paris VI, UMR S 968, institut de la vision, CNRS, UMR 7210, 75012 Paris, France. Electronic address:

Purpose: The purpose of this study was to analyze the change in intraocular pressure (IOP) and glaucoma medications using the XEN Gel Stent as a solo procedure or in association with phacoemulsification in patients with chronic open angle glaucoma (OAG).

Methods: We included cohort studies with at least one year of follow-up in patients with primary open angle glaucoma (POAG), pseudo-exfoliative glaucoma (PXG) or pigmentary glaucoma (PG) who received a XEN gel stent. The main outcome measure was IOP reduction at 12 months follow-up. Read More

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http://dx.doi.org/10.1016/j.jfo.2018.12.002DOI Listing
February 2019
14 Reads

Outcomes of Glaucoma Drainage Device Surgery in Eyes with Treated Uveal Melanoma.

Ocul Oncol Pathol 2019 Jan 2;5(1):20-27. Epub 2018 May 2.

Stein Eye and Doheny Eye Institutes, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, USA.

Aim: We report patient safety and intraocular pressure (IOP) control after placement of a glaucoma drainage device (GDD) in eyes with a history of treated malignant uveal melanoma.

Methods: A retrospective review of the records of patients with uveal melanoma was performed. Outcomes were local tumor recurrence, rate of metastases, and to-nometric success, based on survival curves, defined as IOP < 21 mm Hg. Read More

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https://www.karger.com/Article/FullText/488056
Publisher Site
http://dx.doi.org/10.1159/000488056DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341335PMC
January 2019
29 Reads

Combined Surgical Techniques for the Management of Malignant Glaucoma.

J Ophthalmol 2018 22;2018:9189585. Epub 2018 Nov 22.

Department of Ophthalmology, The First Affiliated Hospital of Zhejiang Chinese Medical University, 54 Youdian Road, Hangzhou, Zhejiang 310006, China.

Purpose: To characterize new combined surgical techniques for the management of malignant glaucoma.

Methods: In a retrospective, interventional case series, goniosynechialysis, peripheral iridectomy, zonulo-hyaloidectomy, and anterior vitrectomy, with or without peripheral capsulectomy, were performed on nine eyes. If the patient was phakic, we performed both phacoemulsification and intraocular lens implantation. Read More

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http://dx.doi.org/10.1155/2018/9189585DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6282139PMC
November 2018
3 Reads

Malignant glaucoma management: literature review.

Tunis Med 2019 Aug - Sep;97(8-9):945-949

Malignant glaucoma remains a challenging complications of ocular surgery. It has been reported to occur spontaneously or after any ophthalmic procedure, it is most commonly encountered after glaucoma surgery. The clinical diagnosis is made in the setting of a patent peripheral iridotomy and axial flattening of the anterior chamber. Read More

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Malignant glaucoma after XEN45 implant.

Arch Soc Esp Oftalmol 2019 Mar 18;94(3):134-137. Epub 2018 Dec 18.

FISABIO Oftalmología Médica, Valencia, España.

Minimally invasive glaucoma surgery for chronic open-angle glaucoma treatment tries to reduce the amount of chronic topical drug treatment, delaying invasive glaucoma surgery and diminishing the number of surgical complications. XEN45 uses subconjunctival drainage in order to reduce intraocular pressure. The report is presented of a patient following phacoemulsification, intraocular lens implantation and XEN45 implant. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03656691183034
Publisher Site
http://dx.doi.org/10.1016/j.oftal.2018.10.023DOI Listing
March 2019
28 Reads