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Sci Rep 2022 Jun 28;12(1):10895. Epub 2022 Jun 28.

Department of Ophthalmology, Seoul National University Bundang Hospital, Seoul National University College of Medicine, 82, Gumi-ro, 173 Beon-gil, Bundang-gu, Seongnam, 463-707, Gyeonggi-do, Korea.

Although central retinal artery occlusion (CRAO) has its own defining pathomechanism and clinical characteristics, morphologic feature of the optic nerve head (ONH) during its later stage is not diagnostic, which makes it difficult to differentiate CRAO from other optic neuropathies. This cross-sectional study was performed to investigate the differences in the topographic morphology of the ONH in eyes with normal-tension glaucoma (NTG) and CRAO. Thirty-one eyes with NTG; 31 eyes with CRAO; and 31 healthy fellow eyes of the subjects with CRAO were included. Read More

Transl Vis Sci Technol 2022 Jun;11(6):10

Department of Ophthalmology and Visual Science, Eye and ENT Hospital, Shanghai Medical College, Fudan University, Shanghai, China.

Purpose: To compare the ocular biomechanical differences between normal controls and patients with untreated primary open angle glaucoma, including normal-tension glaucoma (NTG) and high-tension glaucoma (HTG), and to investigate the association between ocular biomechanics and glaucoma severity in each group.

Methods: One hundred fifty-three eyes of 153 subjects, including 51 controls, 47 NTG, and 55 HTG cases, were enrolled in this cross-sectional study. Each participant underwent biomechanical measurements by using the Corneal Visualization Scheimpflug Technology. Read More

J Ocul Pharmacol Ther 2022 06 25;38(5):354-358. Epub 2022 May 25.

Inouye Eye Hospital, Chiyoda-ku, Tokyo, Japan.

To retrospectively evaluate the 1-year efficacy and safety of single-agent of omidenepag isopropyl in patients with normal-tension glaucoma (NTG). One hundred patients (100 eyes) newly administered omidenepag isopropyl were enrolled. Intraocular pressure (IOP) was compared at baseline and 3, 6, 9, and 12 months after administration. Read More

J Glaucoma 2022 Jul 16;31(7):574-583. Epub 2022 May 16.

Department of Ophthalmology and Research Institute of Medical Sciences, Chonnam National University Medical School and Hospital, Gwangju, South Korea.

Purpose: The aim was to investigate and compare the characteristics of visual field (VF) defects in primary open angle glaucoma (POAG) and normal-tension glaucoma (NTG) with advanced glaucomatous damage and to determine whether the structure-function relationships found in advanced glaucoma differ based on their glaucoma classification.

Patients And Methods: Ninety-seven eyes of 97 patients (59 eyes with POAG and 38 eyes with NTG) with advanced glaucoma were included in this cross-sectional study. Scores at each test point of the 30-2 VF total deviation map were recorded, and average values at each test point were point-wise compared between the groups. Read More

J Glaucoma 2022 May 1;31(5):322-328. Epub 2022 Mar 1.

Yoon Seul Eye Clinic, Daejeon, Korea.

Prcis: Although there was little difference in overall vision-related quality of life (VRQOL) between patients with normal tension glaucoma (NTG) and primary open-angle glaucoma (POAG) after controlling for confounding factors, POAG tended to have poorer VRQOL, especially in social functioning and dependency, than NTG.

Purpose: The fundamental goal of treatment of patients with glaucoma is to preserve their VRQOL. The aim of this study was to compare VRQOL between patients with NTG and those with POAG. Read More

Klin Monbl Augenheilkd 2022 04 26;239(4):460-463. Epub 2022 Apr 26.

Department of Ophthalmology, Cantonal Hospital St. Gallen, St. Gallen, Switzerland.

Cureus 2022 Mar 17;14(3):e23276. Epub 2022 Mar 17.

Department of Ophthalmology, Kaohsiung Medical University Hospital, Kaohsiung, TWN.

A cyclodialysis cleft (CDC) is the detachment of longitudinal ciliary muscle from scleral spur, causing an unusual communication between anterior chamber and suprachoroidal space, resulting in possible hypotony. We report a case of a 63-year-old woman with normal-tension glaucoma (NTG), who developed a shallow anterior chamber with relatively low intraocular pressure (IOP, 6-8 mmHg) after combined ab-interno trabeculotomy and phacoemulsification. Her vision reached good (20/20) with the mild myopic shift. Read More

Sci Rep 2022 04 13;12(1):6217. Epub 2022 Apr 13.

Institute of Health Sciences, School of Medicine, Gyeongsang National University, Jinju, Republic of Korea.

We aimed to obtain microRNA (miRNA) profiles of patients with pseudoexfoliation (PEX) glaucoma or normal-tension glaucoma (NTG) compared to normal controls using individual aqueous humor (AH) samples and investigate the role of miRNAs in the pathogenesis of PEX glaucoma compared to NTG in Korean. AH (80-120 µl) was collected before cataract surgery or trabeculectomy from 26 Korean subjects (eleven with PEX glaucoma, age-matched eight NTG, and seven controls). RNA sequencing was conducted for RNA samples extracted from 26 AH samples. Read More

Int J Environ Res Public Health 2022 04 1;19(7). Epub 2022 Apr 1.

Department of Pharmacology, School of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan.

Patients with NTG or POAG with more than one outpatient or discharge diagnosis from the ophthalmology department were included in the study. These data were merged with the PM data from the Air Quality Monitoring Network for analysis. This was a case-control study, with 1006 participants in the NTG group and 2533 in the POAG group. Read More

Sci Rep 2022 03 24;12(1):5136. Epub 2022 Mar 24.

Department of Ophthalmology, Seoul St. Mary's Hospital, College of Medicine, the Catholic University of Korea, 222 Banpo-daero, Seocho-gu, Seoul, 06591, Republic of Korea.

There is increasing evidence that autonomic dysfunction is an important factor in the progression of glaucoma. Mechanism of the association between autonomic dysfunction and progression of glaucoma is poorly understood. Since blood circulation is basically regulated by the autonomic nervous system, autonomic dysfunction may contribute to unstable or fluctuating blood pressure. Read More

Ophthalmology 2022 Mar 22. Epub 2022 Mar 22.

University College London Institute of Ophthalmology London, London, UK. Electronic address:

Topic: Corneal endothelial cell density (ECD) loss after glaucoma surgery with or without cataract surgery.

Clinical Relevance: Corneal ECD loss may occur as the result of intraoperative surgical trauma in glaucoma surgery or postoperatively with chronic endothelial cell trauma or irritation.

Methods: Glaucoma filtration surgery or microinvasive glaucoma surgery (MIGS) in participants with ocular hypertension, primary and secondary open-angle glaucoma, normal-tension glaucoma, and angle-closure glaucoma were included. Read More

Hong Kong Med J 2022 Feb;28 Suppl 1(1):46-47

Department of Ophthalmology, The University of Hong Kong.

Klin Monbl Augenheilkd 2022 Feb 24;239(2):177-181. Epub 2022 Feb 24.

Departement Biomedizin, Universität Basel, Schweiz.

In addition to aqueous humour and blood, cerebrospinal fluid also plays an important part in the pathophysiology of primary open-angle glaucoma (POAG) and, in particular, normal-tension glaucoma (NTG). Apart from the important role of CSF pressure in papillary congestion, the composition of the CSF and its flow rate are relevant. CSF is in contact with the brain, the spinal canal and the optic nerve. Read More

Klin Monbl Augenheilkd 2022 Feb 24;239(2):146-148. Epub 2022 Feb 24.

Invest Ophthalmol Vis Sci 2022 02;63(2):23

Université de la Polynésie française, Tahiti, French Polynesia.

Purpose: The purpose of this study was to investigate whether the lamina cribrosa (LC) curve changes in response to intraocular pressure (IOP) reduction following administration of topical ocular hypotensive eye drops in eyes with normal tension glaucoma (NTG).

Methods: Ninety-three eyes of 93 patients with treatment naïve NTG at initial examination and with ≥20% reduction from baseline IOP following administration of topical ocular hypotensive eye drops were included. Serial horizontal B-scan images of the optic nerve head (ONH) were obtained from each eye using enhanced depth imaging spectral domain optical coherence tomography (OCT) before and 1 year after IOP-lowering treatment. Read More

Transl Vis Sci Technol 2022 Feb;11(2):17

Health Telematics Science Institute, Kaunas University of Technology, Kaunas, Lithuania.

Purpose: To analyze the cerebrovascular autoregulation (CA) dynamics in patients with normal-tension glaucoma (NTG) and high-tension glaucoma (HTG) as well as healthy subjects using noninvasive ultrasound technologies for the first time.

Methods: The CA status of 10 patients with NTG, 8 patients with HTG, and 10 healthy subjects was assessed, using an innovative noninvasive ultrasonic technique, based on intracranial blood volume slow-wave measurements. Identified in each participant were intraocular pressure, ocular perfusion pressure, and CA-related parameter volumetric reactivity index (VRx), as well as the duration and doses of the longest cerebral autoregulation impairment (LCAI). Read More

Can J Ophthalmol 2022 Feb 3. Epub 2022 Feb 3.

Department of Ophthalmology and Vision Sciences, Faculty of Medicine, University of Toronto, Toronto, Ont.; Department of Medicine, Division of Neurology, Faculty of Medicine, University of Toronto, Toronto, Ont.. Electronic address:

Objective: Nonglaucomatous optic neuropathy (NGON) may often be mistaken for normal-tension glaucoma. The distinction between these two entities is important in determining treatment, prognosis, and need for further investigations. We report characteristics of a cohort of patients referred for neuro-ophthalmologic consultation to distinguish between glaucomatous (GON) and NGON. Read More

Indian J Ophthalmol 2022 Feb;70(2):569-573

Glaucoma Service, Narayana Nethralaya-2, Bengaluru, Karnataka, India.

Purpose: To study the relationship between intraocular pressure (IOP) and mean ocular perfusion pressure (MOPP) in patients with POAG and NTG. The secondary objective was to identify other contributory ischemic factors.

Methods: This was an observational cross-sectional study from a tertiary eye hospital in patients who underwent full-day diurnal variation of tension (DVT). Read More

Sci Rep 2022 01 24;12(1):1221. Epub 2022 Jan 24.

Institute of Vision Research, Department of Ophthalmology, Severance Hospital, Yonsei University, College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, 03722, Republic of Korea.

Previous reports have shown possible association between altered protein levels in aqueous humor (AH) and normal-tension glaucoma (NTG), but the underlying pathogenetic mechanism as well as specific molecular biomarkers for NTG remains still elusive. Here, we aimed to identify novel biomarkers for advanced NTG by analyzing the proteome of patient-derived AH and their correlation with various functional and structural parameters from the visual field test (VF), optical coherence tomography (OCT), and OCT angiography (OCTA). We determined differentially expressed proteins (DEPs) of the AH of patients with advanced NTG (n = 20) using label-free quantitative (LFQ) proteomics with pooled samples and data-independent acquisition (DIA) analysis with individual samples, and the roles of AH DEPs in biological pathways were evaluated using bioinformatics. Read More

Clin Exp Ophthalmol 2022 03 7;50(2):247-259. Epub 2022 Feb 7.

Department of Ophthalmology & Visual Sciences, The Chinese University of Hong Kong, Kowloon, Hong Kong SAR, China.

Normal tension glaucoma (NTG) has remained a challenging disease. We review, from an epidemiological perspective, why we should redefine normality, act earlier at lower pre-treatment intraocular pressure (IOP) level, and the role of ocular perfusion pressures, noting that perfusion is affected by defective vascular bed autoregulation and endothelial dysfunction. The correlation of silent cerebral infarcts (SCI) and NTG may indicate that NTG belongs to a wider spectrum of small vessel diseases (SVD), with its main pathology being also on vascular endothelium. Read More

JAMA Ophthalmol 2022 03;140(3):278-279

Department of Ophthalmology and Visual Sciences, Medical College of Wisconsin, Milwaukee.

J Glaucoma 2022 Jun 2;31(6):e18-e31. Epub 2021 Dec 2.

Department of Ophthalmology, Mayo Clinic, Rochester, MN.

Prcis: For patients with glaucoma, metabolic syndrome was associated with higher intraocular pressure and greater central corneal thickness. Patients with metabolic syndrome were more likely to have ocular hypertension.

Purpose: The purpose of this study was to determine whether glaucomatous optic neuropathy, also known as glaucoma, and ocular hypertension are more likely to occur in patients with metabolic syndrome. Read More

Sci Rep 2021 11 30;11(1):23136. Epub 2021 Nov 30.

Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, 4/F Hong Kong Eye Hospital, 147K Argyle Street, Kowloon, Hong Kong SAR, The People's Republic of China.

To investigate the peripapillary vascular metrics in early normal tension glaucoma (NTG) and early primary angle closure glaucoma (PACG) eyes using optical coherence tomography angiography (OCT-A). One or both eyes of each subject were imaged for a 3 × 3 mm peripapillary region by swept-source OCT-A (DRI-OCT Triton, Topcon, Japan) and assessed by an automated MATLAB program. OCT-A metrics including circumpapillary vessel density (cpVD) and fractal dimension (cpFD) were compared. Read More

Int Ophthalmol 2022 May 25;42(5):1369-1380. Epub 2021 Nov 25.

Rheumatology Division, Escola Paulista de Medicina, Universidade Federal de São Paulo (UNIFESP), Rua Botucatu 740, 3° andar, São Paulo, SP, 04023-062, Brazil.

Purpose: Vasospasm represents an early event in systemic sclerosis (SSc). Ocular vasospasm may induce optic nerve head (ONH) damage and has been involved in the pathogenesis of glaucoma, especially normal-tension glaucoma (NTG). We aimed to investigate the presence of structural abnormalities associated with NTG using swept-source optical coherence tomography (SS-OCT) and to correlate the OCT parameters with clinical, capillaroscopy and digital blood flow measures in patients with SSc. Read More

Int J Ophthalmol 2021 18;14(11):1721-1728. Epub 2021 Nov 18.

Department of Ophthalmology, University of California San Francisco, San Francisco, California 94143, USA.

Aim: To evaluate aspects of cognition impacted by individuals with and without normal tension glaucoma.

Methods: Fifty normal tension glaucoma (NTG) and 50 control patients ≥50y of age were recruited from the UCSF Department of Ophthalmology. Demographic data and glaucoma parameters were extracted from electronic medical records for both groups. Read More

Int Ophthalmol 2022 Apr 5;42(4):1111-1119. Epub 2021 Nov 5.

Department of Ophthalmology, Faculty of Clinical Sciences, Obafemi Awolowo University, Ile-Ife, Nigeria.

Purpose: To describe the pattern of quantitative parasympathetic cardiovascular autonomic function among patients with normal-tension glaucoma (NTG) and high-tension primary open-angle glaucoma (HTG) patients.

Methodology: This was cross-sectional study of ninety-two subjects enrolled into three groups: HTG (31 patients), NTG (31 patients) and Control (30 patients). All the participants had anthropometric assessment, ophthalmic examination, baseline cardiovascular examination and the three parasympathetic components of Ewing's battery of autonomic cardiovascular function tests namely heart rate (HR) response to deep breathing, HR response to Valsalva manoeuvre and HR response to standing. Read More

J Glaucoma 2022 01;31(1):15-22

Department of Ophthalmology, Mayo Clinic, Rochester, MN.

Prcis: Multiple systemic vascular-associated conditions including systemic hypertension and hypotension, diabetes mellitus, migraine headache, peripheral vascular disease, Raynaud syndrome, and anemia were associated with low-tension glaucoma.

Purpose: The purpose of this study was to identify systemic risk factors associated with low-tension glaucoma.

Patients And Methods: A retrospective case-control study design was employed to identify patients seen at the Mayo Clinic Department of Ophthalmology between 2005 and 2015 with low-tension glaucoma and an age-matched and sex-matched control group, each containing 277 patients. Read More

Sci Rep 2021 11 1;11(1):21391. Epub 2021 Nov 1.

Department of Ophthalmology, Asan Medical Center, College of Medicine, University of Ulsan, 388-1 Pungnap-2-dong, Songpa-gu, Seoul, 138-736, Korea.

The present study investigated the characteristics of choroidal microvasculature dropout (CMvD) in eyes with nonarteritic anterior ischemic optic neuropathy (NAION) versus those in eyes with normal-tension glaucoma (NTG). This study included 27 NAION, 27 NTG, and 27 healthy control subjects. CMvD was observed in 15 eyes (55. Read More

Genes (Basel) 2021 10 15;12(10). Epub 2021 Oct 15.

Department of Ophthalmology, University of Pennsylvania, Philadelphia, PA 19104, USA.

is one of a number of genes implicated in the pathogenesis of adult-onset primary open angle glaucoma (POAG). Here we describe in detail the phenotype of a patient with pathogenic variation in who presented with a protracted history of central vision loss. On exam visual acuities were at 20/100 level, had a tritan color defect and showed central arcuate visual field defects on visual field testing. Read More