Search Our Scientific Publications & Authors

J Glaucoma 2020 Jul 7. Epub 2020 Jul 7.

Doheny Image Reading Center, Doheny Eye Institute, 1355 San Pablo Street, Los Angeles, CA 90033, USA.

PRéCIS:: Our study demonstrated that in low-tension glaucoma patients, MP3- and HFA- derived retinal sensitivities were similar and strongly correlated, allowing the respective data to be interrelated.

Purpose: To compare and correlate retinal sensitivities obtained by Nidek Microperimetry-3 (MP-3) with those obtained from the Humphrey Field Analyzer (HFA) in eyes with low-tension glaucoma (LTG).

Methods: In this prospective comparative study, 45 eyes of 24 LTG patients underwent retinal sensitivity assessments using the MP-3 (Nidek Technologies) and the HFA (Carl Zeiss Meditec) at the UCLA-Doheny Eye Center. Read More

Acta Radiol 2020 Jun 22:284185120926901. Epub 2020 Jun 22.

Department of Ophthalmology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi Province, PR China.

Background: We know little about the changes of brain activity in patients with normal-tension glaucoma (NTG).

Purpose: To investigate the altered spontaneous brain activity in patients with NTG through the resting state functional magnetic resonance imaging-fractional amplitude of low-frequency fluctuation (rsfMRI-fALFF) technique, and to explore the relationship with optical coherence tomography (OCT) and field of vision.

Material And Methods: Twenty patients with NTG and 20 healthy controls (HCs) (matched for sex, age, and level of education) were enrolled. Read More

Medicine (Baltimore) 2020 Jun;99(25):e20066

Department of Ophthalmology, Uijeongbu St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.

Previous studies have reported the association of the S1 RNA binding domain 1 (SRBD1) gene with open-angle glaucoma in various ethnic populations. However, in those studies, the definition of the patients differed, as did the results. Therefore, the relevance of the SRBD1 gene to normal tension glaucoma (NTG) appears uncertain at present. Read More

Microorganisms 2020 Jun 13;8(6). Epub 2020 Jun 13.

Department of Internal Medicine, Second Medical Clinic, Ippokration Hospital, Aristotle University of Thessaloniki, 54642 Thessaloniki, Macedonia, Greece.

: Glaucoma is the second most common cause of blindness worldwide affecting almost 70 million individuals. is a widespread pathogen with systematic pathogenicity. This meta-analysis aimed to estimate the contradictory data regarding a potential association between active infection and glaucoma. Read More

Asia Pac J Ophthalmol (Phila) 2020 May-Jun;9(3):157-158

Department of Ophthalmology, Medical Faculty Mannheim, Heidelberg University, Germany.

Sci Rep 2020 May 18;10(1):8203. Epub 2020 May 18.

Department of Ophthalmology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, 222 Banpo-daero, Seocho-gu, Seoul, 06591, Republic of Korea.

In meta-analyses, it has been reported that myopia is a risk factor for glaucoma and there is increasing evidence that autonomic dysfunction causing vascular dysregulation or perfusion dysfunction is considered an important factor in the progression of glaucoma. There have been experimental studies to find out the association between autonomic nervous system and ocular growth, but no clinical study yet has evaluated the relationship between them. Therefore, we enrolled 208 open angle glaucoma patients and measured heart-rate-variability(HRV). Read More

Vestn Oftalmol 2020 ;136(2):49-55

S.M. Kirov Military Medical Academy, St. Petersburg, Russia.

Introduction: Studying the factors that contribute to the disturbance of transmembrane pressure gradient is a topical task in the research of pathogenesis of normal-tension glaucoma (NTG).

Purpose: To measure and compare the thickness and depth of lamina cribrosa (LCT and LCD), as well as optic nerve subarachnoid space width (ONSASW) in patients with NTG and healthy individuals.

Material And Methods: The first group included 12 patients (23 eyes) aged from 58 to 74 years (average age 66. Read More

Medicine (Baltimore) 2020 Mar;99(13):e19468

College of Medicine, Chang Gung University, Taoyuan.

This study characterized and evaluated normal tension glaucoma (NTG) in obstructive sleep apnea syndrome (OSAS).In this retrospective, cross-sectional study, all participants were examined with polysomnography (PSG). Functional parameters of standard automated perimetry (SAP) were recorded. Read More

J Glaucoma 2020 Jun;29(6):498-503

Eleta Eye Institute, Eleta, Ibadan.

Purpose: To determine the correlation and agreement between intraocular pressure (IOP) parameters evaluated by the modified diurnal tension curve (mDTC) and the water drinking test (WDT) in primary open-angle glaucoma (POAG) in an indigenous African population.

Materials And Methods: This was a prospective, interventional, comparative study of 50 newly diagnosed, previously untreated primary open-angle glaucoma patients at the out-patient clinic of the Eleta Eye Institute, Ibadan. A series of IOP measurements were taken 2 hourly (from 7:00 AM to 3:00 PM) for the mDTC, using Goldmann applanation tonometer. Read More

Jpn J Ophthalmol 2020 May 15;64(3):278-284. Epub 2020 Feb 15.

Department of Ophthalmology, Seoul National University Hospital, Seoul National University College of Medicine, 101 Daehak-ro, Jongno-gu, Seoul, 03080, Republic of Korea.

Purpose: To quantitatively analyze the topographic features of localized retinal nerve fiber layer (RNFL) defects according to baseline intraocular pressure (IOP) level in cases of early primary open-angle glaucoma (POAG).

Study Design: Retrospective comparative study.

Methods: POAG patients meeting the following conditions were consecutively included: (1) baseline office-hour diurnal IOP ≤ 21 mmHg, (2) 1 localized RNFL defect as observed on red-free fundus photography, and (3) corresponding visual field defect. Read More

Medicine (Baltimore) 2020 Feb;99(7):e19126

Department of Ophthalmology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.

Structural differences have been reported between primary open angle glaucoma (POAG) and normal tension glaucoma (NTG), and biomechanical differences between POAG and NTG may account for why NTG patients are more vulnerable to lower intraocular pressure (IOP). This study compared the biomechanical properties of POAG and NTG patients using the Corvis scheimpflug technology (ST) non-contact Scheimpflug-based tonometer, and determined the factors associated with these properties.In this retrospective cross-sectional study, 46 eyes with POAG, 54 eyes with NTG, and 61 control eyes were included. Read More

Medicine (Baltimore) 2020 Feb;99(6):e18836

The Eye Hospital of Wenzhou Medical University, Zhejiang Eye Hospital.

Rationale: Malignant glaucoma is a refractory glaucoma which often relentlessly worsened despite conventional therapy. Ultrasonographic biomicroscopy always cannot show the ciliary-block of malignant glaucoma. We report a case of capsular tension ring induced ciliary-block and successfully treated by low dose laser cyclophotocoagulation, with 1-year follow-up. Read More

Am J Ophthalmol 2020 06 24;214:52-62. Epub 2020 Jan 24.

Department of Ophthalmology and Visual Sciences, Carver College of Medicine, University of Iowa Hospitals and Clinics, Iowa City, Iowa, USA. Electronic address:

Purpose: To characterize features of glaucoma associated with a TANK binding kinase 1 (TBK1) gene duplication, which is among the most common molecularly defined causes of normal tension glaucoma (NTG).

Design: Retrospective observational case series.

Methods: We conducted a retrospective case series, by reviewing medical records of 7 members of a pedigree with NTG caused by TBK1 gene duplications. Read More

Sci Rep 2020 01 14;10(1):221. Epub 2020 Jan 14.

Department of Ophthalmology, Seoul National University College of Medicine, Seoul, Korea.

Primary open-angle glaucoma (POAG) can develop even within normal ranges of intraocular pressure, and this type of glaucoma (so-called 'normal-tension glaucoma [NTG]') is highly prevalent in East Asia including Korea and Japan. We conducted exome chip analysis to identify low-frequency and rare variants associated with POAG from the primary cohort (309 POAG patients and 5,400 control, all Koreans). For replication, Korean (310 POAG patients and 5,612 controls) and Japanese (565 POAG patients and 1,104 controls) cohorts were further investigated by targeted genotyping. Read More

Rom J Ophthalmol 2019 Oct-Dec;63(4):346-353

Department of Ophthalmology, Gajra Raja Medical College, Gwalior, India.

To study the hemodynamic parameters in ophthalmic artery (OA) using color Doppler imaging in subjects with primary open-angle glaucoma (POAG), normal-tension glaucoma (NTG) and age matched normals. Sixty-eight eyes of 68 subjects (41 males and 27 females) constituted material for this prospective observational study. They were divided into three groups; Group A had 24 patients with POAG, Group B had 18 patients with NTG and Group C had 26 normal subjects. Read More

Eye (Lond) 2020 Jun 16;34(6):1142-1148. Epub 2019 Dec 16.

School of Health Professions, Plymouth University, Plymouth, UK.

Objectives: To determine the efficacy of toric intraocular lens (TIOL) implantation in cataract surgery patients with high levels of pre-operative corneal astigmatism and ocular co-morbidities in a state funded, National Health Service (NHS) hospital.

Methods: Retrospective cohort study involving consecutive cases of TIOL implantation in cataract surgery with over 3.00DC of pre-operative corneal astigmatism. Read More

Asia Pac J Ophthalmol (Phila) 2019 Nov-Dec;8(6):419-421

Einhorn Clinical Research Center, New York Eye and Ear Infirmary of Mount Sinai, New York, NY.

Med Hypothesis Discov Innov Ophthalmol 2019 1;8(4):278-282. Epub 2019 Oct 1.

Beyoglu Resat Belger Eye Training and Research Hospital, Istanbul Saglik Bilimleri University, Istanbul, Turkey.

Normal tension glaucoma (NTG) is a subtype of glaucoma that occurs at relatively low intraocular pressure levels and results in progressive optic neuropathy. Previous studies display some abnormal immune activity against the optic nerve. Neutrophil to lymphocyte (NLR) and platelet to lymphocyte ratios (PLR) are novel markers for inflammation. Read More

J Glaucoma 2019 12;28(12):e180-e181

Department of Ophthalmology, RWTH Aachen University, Aachen, Germany.

J Glaucoma 2019 11;28(11):952-957

Department of Ophthalmology, Faculty of Medicine, University of Malaya Eye Research Centre, Kuala Lumpur, Malaysia.

Precis: This 5-year follow-up study on normal-tension glaucoma (NTG) patients demonstrated that those with baseline central visual field (VF) defect progress at a more increased rate compared with those with peripheral field defect.

Purpose: The purpose of this study was to investigate the clinical characteristics, including 24-hour ocular perfusion pressure and risk of progression in patients with baseline central VF defect, as compared with those with peripheral VF defect in NTG.

Design: This was a prospective, longitudinal study. Read More

Am J Ophthalmol 2020 03 21;211:31-41. Epub 2019 Oct 21.

Department of Radiology, Vanderbilt University, Nashville, Tennessee, USA.

Purpose: Periventricular leukomalacia (PVL) is a structural loss of white matter pathways that carry visual information from the lateral geniculate bodies to the visual cortex. It is observed radiologically in patients with a history of prematurity and is associated with visual field (VF) defects and optic disc cupping. Advances in perinatal care have improved survival for premature babies, so many now present as adolescents and adults to comprehensive eye doctors who are unaware of the relationship of cupping, field defects, and prematurity and who may diagnose manifest or suspected normal tension glaucoma. Read More

J Ophthalmol 2019 19;2019:3632197. Epub 2019 Sep 19.

Department of Ophthalmology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, Hong Kong.

Glaucoma is the leading cause of irreversible blindness worldwide and the prevalence is on the rising trend. Intraocular pressure (IOP) reduction is the mainstay of treatment. The current practice of IOP monitoring is based on spot measurements during clinic visits during office hours. Read More

Jpn J Ophthalmol 2019 Nov 17;63(6):457-466. Epub 2019 Oct 17.

Department of Ophthalmology, Toho University Ohashi Medical Center, 2-22-36 Ohashi, Meguro-ku, Tokyo, 153-8515, Japan.

Purpose: To investigate macular vessel density (MVD) and structural alterations in untreated normal tension glaucoma (NTG) with a hemifield defect (HFD) and to compare these with the findings in healthy eyes.

Study Design: Case series with a healthy group for comparison.

Methods: Thirty-four eyes of 34 untreated NTG patients with HFD and 28 eyes of 28 healthy subjects were enrolled. Read More

Sci Rep 2019 10 16;9(1):14852. Epub 2019 Oct 16.

Visual Research Project, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan.

The common marmoset (Callithrix jacchus) is a non-human primate that provides valuable models for neuroscience and aging research due to its anatomical similarities to humans and relatively short lifespan. This study was carried out to examine whether aged marmosets develop glaucoma, as seen in humans. We found that 11% of the aged marmosets presented with glaucoma-like characteristics; this incident rate is very similar to that in humans. Read More

BMC Ophthalmol 2019 Oct 7;19(1):203. Epub 2019 Oct 7.

Department of Ophthalmology, Peking University First Hospital, 8 Xi Shi Ku Street, Xi Cheng District, Beijing, 100034, People's Republic of China.

Background: Glaucoma, an important cause of visual impairment in many countries, remains a common eye condition due to difficulties in its early diagnosis. We analyzed the characteristics of retinal arteries to add a valuable technology for helping the normal tension glaucoma (NTG) diagnosis.

Methods: This study included 51 patients with newly diagnosed NTG with hemifield defects and 60 age-matched controls. Read More

Clin Ophthalmol 2019 27;13:1935-1945. Epub 2019 Sep 27.

Department of Ophthalmology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.

Purpose: To evaluate parafoveal and peripapillary perfusion in healthy, glaucoma suspect, normal-tension glaucoma, and primary open-angle glaucoma subjects.

Patients And Methods: This was a retrospective cross-sectional study with optical coherence tomography angiography imaging with RTVue XR Avanti (Optovue, Inc., Fremont, CA) of 56 eyes (14 healthy, 14 glaucoma suspect, 16 normal-tension glaucoma, and 12 primary open-angle glaucoma) at a tertiary academic referral center. Read More

J Glaucoma 2019 11;28(11):1006-1011

Department of Ophthalmology and Research Institute of Medical Sciences, Chonnam National University Medical School and Hospital, Gwangju, South Korea.

PRéCIS:: Although the circumpapillary retinal nerve fiber layer (cpRNFL) reached the measurement floor, the nasal macular region is important for assessing central visual function in advanced glaucoma.

Purpose: To investigate the relationship between the central visual field (VF) and macular parameters obtained from spectral-domain optical coherence tomography (SD-OCT) in patients with advanced glaucoma that reached the cpRNFL thickness measurement floor and to determine whether the structural changes measured by SD-OCT are useful for estimating the functional status in these patients.

Methods: A total of 68 eyes from 68 patients with advanced glaucoma were included. Read More

Med Hypotheses 2019 Dec 24;133:109405. Epub 2019 Sep 24.

Xiamen Eye Center, Xiamen University, China. Electronic address:

Primary open angle glaucoma (POAG) represents a distinct disease entity with elevated intraocular pressure (IOP) as the main risk factor, even though the reasons for why the IOP is elevated remains to be elucidated. It is considered that normal tension glaucoma (NTG) is a subtype of POAG, comprising a special form of glaucomatous neurodegeneration or glaucomatous optic neuropathy (GON) almost exactly the same as that seen in POAG, but the IOP, as named, remains in the statistically normal range. Actually the disease entity of NTG has been a profound confusion and it is difficult to be accurately conceptualized. Read More

Prog Retin Eye Res 2020 03 23;75:100799. Epub 2019 Sep 23.

North Texas Eye Research Institute, University of North Texas Health Science Center, Fort Worth, Texas, USA; Department of Pharmacology & Neuroscience, University of North Texas Health Science Center, Fort Worth, Texas, USA. Electronic address:

Glaucoma is one of the leading causes of vision impairment worldwide. In order to further understand the molecular pathobiology of this disease and to develop better therapies, clinically relevant animal models are necessary. In recent years, both the rat and mouse have become popular models in glaucoma research. Read More

Cesk Slov Oftalmol 2019 ;75(2):55-60

The study provides an up-to-date overview of pathogenesis, functional and structural changes in normal tension glaucoma (NTG) and its differences from high tension glaucomas (HTG). The authors point to less known facts which make both diagnostic groups different. First of all, there are electrophysiological findings that verify pathology in the complete visual pathway in HTG in contrast to NTG where the retinal ganglion cell response is relatively normal but the abnormalities are in the visual pathway. Read More

Molecules 2019 Sep 11;24(18). Epub 2019 Sep 11.

Niigata University of Pharmacy and Applied Life Sciences, 265-1 Higashijima, Akiha-ku, Niigata 956-8603, Japan.

Anthocyanin (AC) is widely used as supplement of eye health in Europe and in East Asia. In this review, I describe AC effects to clarify the mechanism is important in order to understand the effects of AC on vision health. The bioavailability of AC is quite low but, reported as intact form and many kinds of metabolite. Read More

Am J Ophthalmol 2020 01 5;209:77-87. Epub 2019 Sep 5.

Department of Ophthalmology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea. Electronic address:

Purpose: To investigate the natural clinical course and the risk factors of visual field (VF) progression in untreated normal-tension glaucoma (NTG) with myopia with a minimum 3-year follow-up.

Design: Retrospective cohort study.

Methods: Kaplan-Meier survival analysis and log-rank test were used to compare survival experiences between the groups. Read More

Invest Ophthalmol Vis Sci 2019 09;60(12):3696-3707

Visual Research Project, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan.

Purpose: We assess if α retinal ganglion cells (αRGCs) and intrinsically photosensitive retinal ganglion cells (ipRGCs) survive in mouse models of glaucoma.

Methods: Two microliters of N-methyl-D-aspartate (NMDA; 1 mM) or PBS were injected intraocularly 7 days before sacrifice. Immunohistochemical analyses of the retina were performed using antibodies against RNA-binding protein with multiple splicing (RBPMS), osteopontin, and melanopsin. Read More

Br J Ophthalmol 2020 May 3;104(5):623-628. Epub 2019 Sep 3.

Department of Ophthalmology, Seoul National University, Seoul, Republic of Korea

Background/aims: To investigate (1) the effect of reading or writing on a smartphone in terms of intraocular pressure (IOP) change in eyes with glaucoma, and (2) to determine whether previous glaucoma filtering surgery can affect IOP fluctuation during such work.

Methods: Forty eyes of 40 medically well IOP-controlled normal-tension glaucoma (NTG) patients and 38 eyes of 38 NTG patients who had undergone successful trabeculectomy (TLE) were enrolled. The participants were instructed to read a sample text and to then type it on a smartphone under low-light [100 lux] conditions. Read More

Jpn J Ophthalmol 2019 Sep 31;63(5):402-409. Epub 2019 Jul 31.

Yotsuya-Shirato Eye Clinic, Tokyo, Japan.

Purpose: To assess the efficacy and safety of filtration surgery using the EX-PRESS glaucoma filtration device in patients with normal-tension glaucoma (NTG).

Study Design: Prospective, single-arm, multicenter interventional case series.

Methods: Eyes with NTG underwent EX-PRESS implantation with or without cataract surgery. Read More

J Glaucoma 2019 09;28(9):823-833

Department of Medicine, University of Udine, Udine, Italy.

Purpose: The purpose of this study was to conduct a meta-analysis on the efficacy and safety of trabeculectomy (TE) and nonpenetrating glaucoma surgery (NPGS) techniques in patients with primary open-angle glaucoma, pseudoexfoliation glaucoma, pigmentary glaucoma, and normal-tension glaucoma.

Methods: All studies were identified by searching electronic sources (PubMed, Medline, Scopus, and Embase) until February 5, 2018. Primary outcome was mean intraocular pressure (IOP) reduction at 6, 12, and 24 months. Read More

Indian J Ophthalmol 2019 08;67(8):1297-1302

Department of Ophthalmology, College of Medicine; Department of Ophthalmology, Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan, South Korea.

Purpose: To compare the lipid layer thickness (LLT) using the LipiView® ocular surface interferometer (TearScience® Inc, Morrisville, NC) between the eye treated with glaucoma medication and untreated normal eye in the unilateral glaucoma patients, and evaluate the effect of topical glaucoma medication on the LLT parameters in glaucoma eyes.

Methods: The participants in this cross-sectional comparative study were unilateral glaucoma patients treated with topical glaucoma medications for more than 12 months. Three LLT parameters (average, minimum, and maximum) obtained by the LipiView® were compared between the glaucomatous eye and normal eye. Read More

Ophthalmology 2019 08;126(8):1117-1118

J Glaucoma 2019 09;28(9):834-842

Department of Ophthalmology, College of Medicine, Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul, Republic of Korea.

Purpose: The aim of this study was to compare the diagnostic power of optic nerve head and posterior scleral configuration parameters obtained with the swept-source optical coherence tomography (SSOCT) on myopic normal-tension glaucoma (NTG).

Materials And Methods: A total of 203 eyes of 203 participants with myopia diagnosed at Seoul Saint Mary's Hospital between September 2016 and February 2018 were divided into myopic NTG group (n=113) and nonglaucomatous myopia group (n=90). Established optic nerve head (ONH) parameters such as disc torsion, horizontal tilt, and vertical tilt, and novel parameters representing posterior sclera, were quantified using SSOCT. Read More

Graefes Arch Clin Exp Ophthalmol 2019 Sep 17;257(9):1963-1970. Epub 2019 Jun 17.

Fukui-ken Saiseikai Hospital, 7-1 Wadanaka-machi Funabashi, Fukui, Fukui Prefecture, 918-8503, Japan.

Purpose: In order to clarify the association between peripapillary vascular changes and disc hemorrhage (DH) occurrences over time, we analyzed the density of radial peripapillary capillary (RPC) and clinical parameters during follow-up periods in patients with normal-tension glaucoma (NTG).

Methods: Seventy-seven eyes of 77 NTG patients were subjected to analysis. We selected patients who had an initial optical coherence tomography angiography (OCTA) scan in 2015 and who had another OCTA scan in 2018 with both OCTA scans showing good-quality images. Read More

Dis Markers 2019 6;2019:5820537. Epub 2019 May 6.

Department of Ophthalmology & Visual Sciences, The Chinese University of Hong Kong, Hong Kong.

Purpose: To study the roles of sequence alterations in the optineurin () gene-coding region in normal-tension glaucoma (NTG) among Chinese patients.

Methods: Genomic DNA was extracted from 190 NTG patients and 201 control subjects. The thirteen exons of were amplified by polymerase chain reaction and analyzed by direct sequencing. Read More

J Glaucoma 2019 08;28(8):e146-e147

Ophthalmology Department, King's College Hospital, Denmark Hill, London, UK.

Invest Ophthalmol Vis Sci 2019 06;60(7):2461-2467

Department of Ophthalmology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

Purpose: To compare the local distribution of prelaminar and neuroretinal rim (NRR) thickness between eyes with nonarteritic anterior ischemic optic neuropathy (NAION) and normal tension glaucoma (NTG) using enhanced depth imaging spectral-domain optical coherence tomography (OCT).

Methods: This cross-sectional study included pairs of NAION and NTG patients, and controls. We measured the central prelaminar thickness; Bruch's membrane opening (BMO)-horizontal (HRW), minimal (MRW), and vertical rim widths (VRW), and vertical/horizontal thicknesses at knee of curve at rising curvature of the cup wall. Read More

Invest Ophthalmol Vis Sci 2019 06;60(7):2423-2430

Université de la Polynésiefrançaise, Tahiti, French Polynesia.

Purpose: To investigate intereye differences in lamina cribrosa (LC) morphology in normal tension glaucoma (NTG) patients with unilateral damage.

Methods: A total of 152 eyes of 76 treatment-naive NTG patients with unilateral damage from the ongoing Investigating Glaucoma Progression Study were included. Optic nerve heads were scanned using enhanced-depth spectral-domain optical coherence tomography. Read More

Zhonghua Yan Ke Za Zhi 2019 May;55(5):338-346

Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Institute of Ophthalmology, Beijing Ophthalmology & Visual Sciences Key Lab., Beijing 100730, China.

To investigate the relationship between the spontaneous focal lamina cribrosa (LC) defect and the progression of visual field defect (VFD) in primary open-angle glaucoma (POAG). Case-control study. The patients who were diagnosed as POAG with at least 5 visual field results had been collected from June 2018 to January 2019 at Beijing Tongren Hospital Affiliated to Capital Medical University. Read More

Invest Ophthalmol Vis Sci 2019 05;60(6):2198-2207

Department of Ophthalmology, College of Medicine, Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul, Republic of Korea.

Purpose: To investigate factors associated with visual field (VF) progression in treated myopic normal-tension glaucoma (NTG) using a novel posterior sclera reconstruction method involving swept-source optical coherence tomography (OCT).

Methods: Fifty-six myopic patients on ocular hypotensive therapy with the diagnose NTG had five or more VF tests during a period of 72.63 ± 20. Read More

Ophthalmic Res 2019 17;62(1):46-54. Epub 2019 May 17.

Department of Ophthalmology, Show Chwan Memorial Hospital, Changhua, Taiwan.

Objectives: Evaluate the correlation between basal macular circulation and late structural damage in progressed high-tension glaucoma (HTG) and normal-tension glaucoma (NTG) via optical coherence tomography angiography (OCTA).

Methods: Patients who received an OCTA examination were divided into progressed HTG, progressed NTG, and well-controlled HTG (control) groups. Superficial macular vessel density (SmVD), deep macular vessel density (DmVD), foveal avascular zone (FAZ), and flow area of the outer retina and choriocapillaris were obtained by one OCTA device. Read More

Med Hypotheses 2019 Jun 13;127:97-99. Epub 2019 Apr 13.

Department of Psychiatry, PC Sint-Amandus, Reigerlostraat 10, 8730 Beernem, Belgium. Electronic address:

Glaucoma is a leading cause of irreversible blindness worldwide. Primary open-angle glaucoma, the most common type, is characterized by progressive degeneration of retinal ganglion cells and their axons in the optic nerve, resulting in progressive deterioration of visual fields. The optic nerve head is generally considered to be the primary site of axonal injury in glaucoma. Read More

Cell Death Dis 2019 05 7;10(5):364. Epub 2019 May 7.

Department of Ophthalmology, Baylor College of Medicine, One Baylor Plaza, NC 205, Houston, TX, 77030, USA.

The transient receptor potential vanilloid 4 (TRPV4) channel may be opened by mechanical stimuli to mediate Ca and Na influxes, and it has been suggested to mediate glaucoma retinopathy. However, it has been mostly unclear how TRPV4 activities affect the function of primate retinal ganglion cells (RGCs). We studied RGCs and bipolar cells (BCs) in the peripheral retina of the old-world primate using whole-cell current-clamp and voltage-clamp recordings, immunomarkers and confocal microscopy. Read More

Br J Ophthalmol 2020 01 4;104(1):81-86. Epub 2019 May 4.

Department of Ophthalmology, Seoul National University College of Medicine, Seoul, Korea

Background/aims: To investigate the risk factors for disease progression of normal-tension glaucoma (NTG) with pretreatment intraocular pressure (IOP) in the low-teens.

Methods: One-hundred and two (102) eyes of 102 patients with NTG with pretreatment IOP≤12 mm Hg who had been followed up for more than 60 months were retrospectively enrolled. Patients were divided into and groups according to visual field (VF) progression as correlated with change of optic disc or retinal nerve fibre layer defect. Read More