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J Am Anim Hosp Assoc 2022 May;58(3):121-128

From MedVet, Columbus, Ohio (T.W.).

The objective of this study was to determine the complication risk and prevalence after phacoemulsification in cats with presumed congenital/inherited cataracts. Twelve client-owned cats were included in the study. This retrospective study spanned 13 yr and involved 22 eyes. Read More

Am J Ophthalmol 2022 May 2. Epub 2022 May 2.

Department of Ophthalmology, University Medical Center Utrecht, Utrecht, The Netherlands.

Purpose: To examine the clinical course and outcome in children with idiopathic chronic anterior uveitis (iCAU) and compare the results with age-matched children with juvenile idiopathic arthritis-associated uveitis (JIA-U).

Design: Retrospective cohort study.

Methods: Data regarding ocular complications, visual acuity, and systemic treatment were retrospectively collected for two patient groups that were matched regarding age and year of uveitis diagnosis. Read More

Hum Mutat 2022 May 1. Epub 2022 May 1.

The authors and editors wish to correct this article with regard to some revisions made by the authors which were approved by the editors but were not present in the published version of record This article is protected by copyright. All rights reserved. Read More

Front Med (Lausanne) 2022 1;9:874369. Epub 2022 Apr 1.

Henan Eye Institute, Henan Eye Hospital, Henan Provincial People's Hospital, Zhengzhou University People's Hospital, Zhengzhou, China.

Purpose: We aimed to describe the characteristics, epidemiology, management, and outcomes of glaucoma in pediatric patients in central China.

Methods: This study retrospectively analyzed inpatients with pediatric glaucoma at Henan Provincial People's Hospital, Henan Eye Institute, and Henan Eye Hospital between 2017 and 2020.

Results: Overall, 239 cases (276 eyes) of pediatric glaucoma in patients, comprising 87 girls (36. Read More

Mol Biol Rep 2022 Apr 1. Epub 2022 Apr 1.

Department of Ophthalmology and Ophtha-Lab, St. Franziskus-Hospital, Hohenzollernring 74, 48145, Münster, Germany.

Purpose: Juvenile idiopathic arthritis-associated uveitis (JIAU) may run a chronic and treatment-resistant course, and occasionally, alterations of the iris vasculature may be observed clinically.

Methods: Iris tissue (IT), aqueous humor (AH) and serum samples from patients with clinically inactive JIAU (n = 30), acute anterior uveitis (AAU; n = 18), and primary open angle glaucoma (POAG; n = 20) were obtained during trabeculectomy or cataract surgery. Samples were analyzed by RNA-Seq, qRT-PCR, LC-IMS, Western-Blot, and LEGENDplex™ analysis. Read More

Int Ophthalmol 2022 Mar 30. Epub 2022 Mar 30.

Department of Ophthalmology, Başkent University Faculty of Medicine, Ankara, Turkey.

Purpose: To present the outcomes and factors affecting the success of trabeculectomy performed as the first surgery in primary pediatric glaucoma.

Methods: Pediatric patients with primary glaucoma who underwent trabeculectomy as the first surgery were retrospectively reviewed. Age, gender, preoperative intraocular pressure (IOP), operation age, axial length, corneal diameter, anterior segment findings, antimetabolite used, complications, and 1-month, 3-months, 1-year, and most recent postoperative findings were recorded. Read More

Int J Ophthalmol 2022 18;15(2):346-351. Epub 2022 Feb 18.

Second Department of Ophthalmology, Pomeranian Medical University, Szczecin 70-111, Poland.

Aim: To assess the incidence of mitral valve prolapse in patients with newly diagnosed primary open angle glaucoma.

Methods: The study included 12 patients without any other comorbidities or taking any general or local medications. Each patient underwent a full ophthalmological examination with visual field assessment and optical computed tomography of the macula and optic nerve head. Read More

Glob Med Genet 2022 Mar 19;9(1):54-55. Epub 2021 Aug 19.

Department of Laboratory Medicine, National University Hospital Singapore, Singapore.

Eur J Ophthalmol 2022 Feb 9:11206721221077621. Epub 2022 Feb 9.

537068Institute of Applied Ophthalmobiology (IOBA), University of Valladolid, Valladolid, Spain.

Purpose: It had been reported that mutations in gene probably play an important role in the pathogenesis of primary open angle glaucoma (POAG) but the existing genetic association studies show contradictory results. Thus, the objective of our study was to perform a systematic review and meta-analysis to characterize more precisely the potential association between given polymorphisms in gene and the risk of suffering POAG.

Methods: A systematic review of studies that related the risk of carrying gene polymorphisms with POAG development was conducted. Read More

J Glaucoma 2022 Feb 8. Epub 2022 Feb 8.

Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida Department of Ophthalmology and Visual Sciences, University of Wisconsin-Madison, Madison, Wisconsin Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, Massachusetts; Ocular Genomics Institute, Harvard Medical School, Boston, Massachusetts Rosalind Franklin University of Medicine and Science/The Chicago Medical School, North Chicago, Illinois.

Prcis: Glaucoma cascade screening in first degree relatives of young Haitian glaucoma patients had high yield for diagnosing manifest and suspected glaucoma in 30.8% of those screened despite modest participation.

Purpose: To evaluate the outcomes of glaucoma cascade screening in first-degree relatives (FDRs; parents, siblings and offspring) of Haitian juvenile open angle glaucoma (JOAG) patients. Read More

BMC Ophthalmol 2022 Jan 31;22(1):45. Epub 2022 Jan 31.

Kamuzu University of Health Sciences, Blantyre, Malawi.

Background: To describe the clinical characteristics and treatment of primary childhood glaucoma at Queen Elizabeth Central Hospital in Blantyre, Malawi.

Methods: A retrospective case notes review was undertaken of all medical records of patients aged less than 16 years with a diagnosis of primary glaucoma according to the Childhood Glaucoma Research Network Classification (CGRN) who presented from January 2016 to December 2018. The parameters extracted from the case files included age at presentation, sex, type of glaucoma, presenting complaints, laterality of ocular involvement, examination findings and the treatment modality instituted. Read More

Indian J Ophthalmol 2022 Feb;70(2):558-563

Department of Glaucoma, University of Health Sciences, Beyoglu Eye Training and Research Hospital, Istanbul, Turkey.

To compare the quantitative measurements of the anterior chamber angle (ACA) and iris parameters in patients with juvenile open-angle glaucoma (JOAG), pigmentary glaucoma (PG), and healthy controls using anterior segment optical coherence tomography (AS-OCT).

Methods: This was a retrospective, cross-sectional study of 25 eyes with JOAG, 25 eyes with PG, and 25 control eyes. Anterior chamber depth, angle-opening distance 500 and 750, trabecular-iris space 500 and 750, scleral spur angle, iris thickness (IT, measured at the thickest part), and iris bowing were obtained using AS-OCT (Visante" OCT 3. Read More

Acta Ophthalmol 2022 Jan 25. Epub 2022 Jan 25.

Department of Ophthalmology, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.

Purpose: The purpose of the study was to analyse the development of ocular complications and visual prognosis in juvenile idiopathic arthritis associated uveitis (JIA-uveitis) compared to the previous decade in the light of new treatment guidelines.

Methods: In this retrospective cohort, 143 patients with JIA-uveitis were stratified into two cohorts based on the year of diagnosis of uveitis, <2010 (n = 61) and ≥2010 (n = 82). Development of ocular complications and visual outcomes were analysed by univariate and multivariate methods. Read More

Clin Exp Ophthalmol 2022 03 25;50(2):232-246. Epub 2022 Jan 25.

Speciality of Ophthalmology, Save Sight Institute, Faculty of Medicine and Health, The University of Sydney, Sydney, Australia.

Childhood glaucoma represents a heterogenous group of rare ocular conditions that may result in significant sight threatening complications related to elevated intraocular pressure (IOP). It can be classified as either primary or secondary and the latter may have systemic associations. This review will be based on the work of the childhood glaucoma research network (CGRN) and will focus on the diagnosis and management of the most common types of childhood glaucoma. Read More

Saudi J Biol Sci 2022 Jan 25;29(1):96-101. Epub 2021 Aug 25.

Department of Ophthalmology, Liaquat University of Medical and Health Sciences, Jamshoro, Pakistan.

Background: Primary open angle glaucoma (POAG) occurs due to the discrepancies in the angle of anterior chamber characterized by the alterations in intraocular pressure, optic nerves head changes and central loss of visual field. In molecular research, mutations modulates an integral role in association with glaucoma. Current study was undertaken to reveal the homozygous and heterozygous patterns of c. Read More

J Glaucoma 2022 Apr;31(4):280-284

King Khaled Eye Specialist Hospital, Riyadh.

Prcis: In this retrospective study of patients with predominantly severe juvenile open-angle glaucoma, deep sclerectomy (DS) achieved a success rate [defined as intraocular pressure (IOP) between 5 to 18 mm Hg] of 72% at 3 years.

Purpose: The purpose of this study was to evaluate the safety and efficacy of DS in patients with juvenile open-angle glaucoma (JOAG).

Methods: A retrospective chart review of all JOAG patients that underwent DS with mitomycin C at a tertiary care eye center during the period from May 2014 to May 2019. Read More

J Clin Med 2021 Dec 8;10(24). Epub 2021 Dec 8.

Department of Ophthalmology, University Medical Center Mainz, Langenbeckstr. 1, 55131 Mainz, Germany.

To quantify the results of childhood glaucoma treatment over time in a cohort of children with different types of childhood glaucoma. A retrospective cohort study of consecutive cases involving children with primary congenital glaucoma, primary juvenile, and secondary juvenile glaucoma at the Childhood Glaucoma Center, University Medical Center Mainz, Germany from 1995 to 2015 was conducted. The main outcome measure was the long-term development of intraocular pressure. Read More

Hum Mutat 2022 Feb 28;43(2):240-252. Epub 2021 Dec 28.

Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, USA.

Juvenile open-angle glaucoma (JOAG) is a severe type of glaucoma with onset before age 40 and dominant inheritance. Using exome sequencing we identified 3 independent families from the Philippines with novel EFEMP1 variants (c.238A>T, p. Read More

J Med Primatol 2022 Apr 12;51(2):119-123. Epub 2021 Dec 12.

Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California-Davis, Davis, California, USA.

This report describes the clinical and histological findings, genetic study, and treatment in a 1.3-year-old rhesus macaque with bilateral cataracts and unilateral secondary glaucoma. Intravitreal injection of gentamicin decreased the intraocular pressure from 56 to <2 mm Hg. Read More

Genes (Basel) 2021 11 16;12(11). Epub 2021 Nov 16.

Stein Eye Institute, Department of Ophthalmology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.

Glaucoma is the leading cause of irreversible blindness worldwide, with elevated intraocular pressure (IOP) as the only known modifiable risk factor. Trabecular meshwork (TM)-inducible myocilin (the gene) was the first to be identified and linked to juvenile and primary open-angle glaucoma. It has been suggested that mutations in the gene and the aggregation of mutant myocilin in the endoplasmic reticulum (ER) of TM may cause ER stress, resulting in a reduced outflow of aqueous humor and an increase in IOP. Read More

Prog Retin Eye Res 2021 Nov 18:101021. Epub 2021 Nov 18.

Retina and Optic Nerve Research Laboratory, Dalhousie University, Halifax, Nova Scotia, Canada; Department of Medical Neuroscience, Dalhousie University, Halifax, Nova Scotia, Canada; Department of Ophthalmology and Visual Sciences, Dalhousie University, Halifax, Nova Scotia, Canada; Department of Physiology and Biophysics, Dalhousie University, Halifax, Nova Scotia, Canada. Electronic address:

Age and intraocular pressure (IOP) are the two most important risk factors for the development and progression of open-angle glaucoma. While IOP is commonly considered in models of experimental glaucoma (EG), most studies use juvenile or adult animals and seldom older animals which are representative of the human disease. This paper provides a concise review of how retinal ganglion cell (RGC) loss, the hallmark of glaucoma, can be evaluated in EG with a special emphasis on serial in vivo imaging, a parallel approach used in clinical practice. Read More

BMC Ophthalmol 2021 Nov 16;21(1):395. Epub 2021 Nov 16.

Department of Ophthalmology & Visual Science, Eye & ENT Hospital, Shanghai Medical College, Fudan University, 83 Fenyang Rd, Shanghai, 200031, China.

Background: To compare the efficacy and safety of gonioscopy-assisted transluminal trabeculotomy (GATT) and Kahook Dual Blade (KDB) excisional goniotomy in patients with uncontrolled juvenile open-angle glaucoma (JOAG).

Methods: Thirty-three patients (46 eyes) were included in this single-center, retrospective, comparative study and treated with GATT (36 eyes) or KDB goniotomy (13 eyes). Intraocular pressure (IOP), number of glaucoma medications, adverse events, and additional anti-glaucoma procedures were collected during pre- and postoperative visits. Read More

Curr Opin Ophthalmol 2022 Mar;33(2):97-102

Department of Ophthalmology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.

Purpose Of Review: The aim of this article is to summarize up-to-date research on the diagnosis and management of juvenile open-angle glaucoma (JOAG).

Recent Findings: JOAG can be subclassified into four clinical phenotypes, and faster myopic shift is a risk factor for disease progression. Vessel density is associated with structural damage and worsening visual acuity in JOAG and can be monitored with optical coherence tomography angiography. Read More

Am J Ophthalmol 2022 04 22;236:79-88. Epub 2021 Oct 22.

Beijing Tongren Eye Center (Y.S., H.W., C.X., P.Y., L.Z., J.T., Y.Z., K.C., N.W.), Beijing Tongren Hospital, Beijing Institute of Ophthalmology, Capital Medical University, Beijing, China. Electronic address:

Purpose: To identify risk factors for surgical failure after gonioscopy-assisted transluminal trabeculotomy (GATT) in juvenile open-angle glaucoma (JOAG).

Design: Prospective, interventional case series.

Methods: GATT was the initial surgery in 70 eyes of 70 patients with JOAG. Read More

Int Ophthalmol 2022 Feb 5;42(2):411-421. Epub 2021 Oct 5.

Faculty of Medicine, Mansoura University, Mansoura, Egypt.

Purpose: To compare trabeculectomy with Ologen implant(Trab-Ologen) to combined viscotrabeculotomy-synechiolysis(VTS) in uncontrolled uveitic glaucoma (UG).

Patients And Methods: A retrospective chart review of 47 patients subjected to VTS(24 eyes) or Trab-ologen(23 eyes) at Mansoura Ophthalmic Center between 2010 and 2016. The patients were evaluated on day 1, week 1, months 1, 3, 6, 12, 18, 24, 30, 36, 42, and 48. Read More

Genes (Basel) 2021 09 11;12(9). Epub 2021 Sep 11.

Department of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, MI 48105, USA.

Monogenic syndromic disorders frequently feature ocular manifestations, one of which is glaucoma. In many cases, glaucoma in children may go undetected, especially in those that have other severe systemic conditions that affect other parts of the eye and the body. Similarly, glaucoma may be the first presenting sign of a systemic syndrome. Read More

Indian J Ophthalmol 2021 Oct;69(10):2710-2716

Department of Anatomy, All India Institute of Medical Sciences, New Delhi, India.

Purpose: To report the association of procollagen-lysine 2-oxoglutarate 5-dioxygenase 2 (PLOD2) mutations with bilateral primary congenital glaucoma (PCG) in monozygotic twins and with nondominant juvenile-onset primary open-angle glaucoma (JOAG).

Methods: We utilized family-based whole-exome sequencing to detect disease-causing mutations in a pair of monozygotic twins with de-novo PCG and compared its existence in 50 nonfamilial cases of JOAG and 30 healthy controls. To validate the identified mutations, direct Sanger sequencing was performed. Read More

Surv Ophthalmol 2021 Sep 16. Epub 2021 Sep 16.

Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India. Electronic address:

Juvenile-onset open-angle glaucoma (JOAG) is a subset of primary open-angle glaucoma that is diagnosed before 40 years of age. The disease may be familial or non-familial, with proportions varying among different populations. Myocilin mutations are the most commonly associated. Read More

Med Pharm Rep 2021 Aug 10;94(Suppl No 1):S28-S32. Epub 2021 Aug 10.

Department of Pediatrics Clinic I, Emergency Clinical Hospital for Children, Cluj-Napoca, Romania.

Juvenile idiopathic arthritis (JIA) is the most common rheumatic disease in pediatric population, with uveitis as the most common and severe extra-articular manifestation. Eye damage (bilateral in 70-80% of cases) is usually anterior, chronic and asymptomatic. Young age, female gender, oligoarticular form and ANA positivity are risk factors for chronic anterior uveitis (CAU). Read More