814 results match your criteria Glaucoma Juvenile


Comparison of Rates of Fast and Catastrophic Visual Field Loss in Three Glaucoma Subtypes.

Invest Ophthalmol Vis Sci 2019 Jan;60(1):161-167

Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India.

Purpose: To compare the distribution of visual field progression rates in three subgroups of glaucoma, being primary angle-closure glaucoma (PACG), POAG, and juvenile open-angle glaucoma (JOAG).

Methods: We assessed glaucoma patients treated in an Indian tertiary care setting with at least four visual field assessments. We determined rates from a single eye of each of 525 patients using linear regression of the summary index mean deviation (MD) over time. Read More

View Article

Download full-text PDF

Source
http://iovs.arvojournals.org/article.aspx?doi=10.1167/iovs.1
Publisher Site
http://dx.doi.org/10.1167/iovs.18-25391DOI Listing
January 2019
3 Reads
3.404 Impact Factor

Peripapillary capillary vessel density progression in advanced glaucoma: a case report.

Authors:
Gábor Holló

BMC Ophthalmol 2019 Jan 5;19(1). Epub 2019 Jan 5.

Department of Ophthalmology, Semmelweis University, Mária u. 39, Budapest, 1085, Hungary.

Background: We report a case of advanced juvenile open-angle glaucoma (JOAG) in which peripapillary capillary vessel density (PcVD) in the inferior retina showed significant progression while the spatially corresponding retinal nerve fiber layer thickness (RNFLT) and visual field cluster defect values had reached their minimal detectable values, and showed no change during the follow-up (floor effect).

Case Presentation: A 45-year old white female patient with very advanced under treatment JOAG in the left eye was prospectively investigated with the AngioVue OCT (Optovue Inc., Fremont, USA) for RNFLT and PcVD, and Octopus Normal G2 visual field testing, at 6-month intervals for 2. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12886-018-1021-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6321677PMC
January 2019
2 Reads

Comparison of Refractive Status and Anterior Segment Parameters of Juvenile Open-Angle Glaucoma and Normal Subjects

Turk J Ophthalmol 2018 Dec;48(6):295-298

University of Health Sciences, Ulucanlar Eye Research Hospital, Opthalmology Clinic, Ankara, Turkey

Objectives: Our aim was to compare the refractive status and anterior segment parameters of patients with juvenile open-angle glaucoma (JOAG) and normal subjects.

Materials And Methods: Twenty-five recently diagnosed cases of JOAG and 24 normal subjects were included in this prospective controlled clinical trial. Central corneal thickness (CCT), anterior chamber depth (ACD), lens thickness (LT), axial length (AL), K1 and K2 keratometry, and white-to-white distance (WTW) measurements were performed with optical biometry (LenStar LS 900, Haag Streit Diagnostics). Read More

View Article

Download full-text PDF

Source
http://cms.galenos.com.tr/Uploads/Article_21060/TJO-48-295-E
Publisher Site
http://dx.doi.org/10.4274/tjo.68915DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330661PMC
December 2018
11 Reads

X-linked Juvenile Retinoschisis.

Adv Exp Med Biol 2018 ;1085:43-48

Department of Ophthalmology, Columbia University, Edward S. Harkness Eye Institute, NewYork-Presbyterian Hospital, New York, NY, USA.

X-linked juvenile retinoschisis (XLRS) occurs exclusively in males and is characterized by visual loss that begins in early childhood; patients are usually school-age and are experiencing visual disturbances, especially in reading. The prevalence is estimated to be 1 in 5000-25,000 men, worldwide. XLRS has complete penetrance but variable expressivity. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/978-3-319-95046-4_10DOI Listing
January 2018

Juvenile open-angle Glaucoma associated with Leber's hereditary optic neuropathy: a case report and literature review.

BMC Ophthalmol 2018 Dec 17;18(1):323. Epub 2018 Dec 17.

Department of Ophthalmology, Chang-Gung Memorial Hospital, 222 Mai-Chin Rd, Keelung, 204, Taiwan (Republic of China).

Background: Leber's hereditary optic neuropathy (LHON) is a maternally inherited recessive disease rarely complicated with glaucoma. We conducted a clinical and genetic retrospective case series to describe three cases of juvenile open-angle glaucoma (JOAG) and an ND4 m11778G > A mitochondrial DNA (mtDNA) mutation, which is pathognomonic for LHON.

Case Presentation: Patient 1 was a 16-year-old boy diagnosed with bilateral JOAG and high myopia. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12886-018-0980-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6296145PMC
December 2018
1 Read

Short-term Optic Disc Cupping Reversal in a Patient with Mild Juvenile Open-angle Glaucoma Due to Early Idiopathic Intracranial Hypertension.

J Glaucoma 2018 Dec 10. Epub 2018 Dec 10.

Vanderbilt Eye Institute, Vanderbilt University Medical Center, 2311 Pierce Avenue, Nashville, TN, 37232.

Purpose: The purpose of this study is to report a case of optic disc cupping reversal in an adult without significant intraocular pressure lowering treatment.

Patient: A 20-year-old female with a history of mild juvenile open-angle glaucoma who developed subjective blurred vision and a decrease in cupping of her optic discs.

Results: Dilated examination demonstrated decreased cup-to-disc ratios in both eyes with slight blurring of the disc margin in the right eye. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/IJG.0000000000001151DOI Listing
December 2018

Occurrence of MYOC and CYP1B1 variants in juvenile open angle glaucoma Brazilian patients.

Ophthalmic Genet 2018 Dec;39(6):717-724

a Laboratory of Human Genetics, Center for Molecular Biology and Genetic Engineering - CBMEG , University of Campinas - UNICAMP , Campinas , SP , Brazil.

Background: The purpose of this study was to screen juvenile open angle glaucoma (JOAG) patients from Brazil for variants within the MYOC and CYP1B1 genes.

Material And Methods: In this study, we evaluated the coding regions of MYOC and CYP1B1 genes in 100 non-related patients with JOAG and 200 controls through Sanger sequencing. We also tested the most frequent single nucleotide variants of CYP1B1 for association with JOAG. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/13816810.2018.1546405DOI Listing
December 2018

Estimating the age of the p.Cys433Arg variant in the MYOC gene in patients with primary open-angle glaucoma.

PLoS One 2018 16;13(11):e0207409. Epub 2018 Nov 16.

Center for Molecular Biology and Genetic Engineering (CBMEG), University of Campinas (UNICAMP), Campinas, São Paulo, Brazil.

The aim of this study was to estimate the age of the Cys433Arg (c.1297T>C, p.Cys433Arg) variant by comparing the genotypes of individuals affected and not affected by primary open angle glaucoma juvenile onset (JOAG). Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0207409PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6239314PMC
November 2018
7 Reads

Stemming retinal regeneration with pluripotent stem cells.

Prog Retin Eye Res 2018 Nov 9. Epub 2018 Nov 9.

Laboratory for Retinal Regeneration, RIKEN Center for Developmental Biology, Kobe, Hyogo, 650-0047, Japan.

Cell replacement therapy is a promising treatment for irreversible retinal cell death in diverse diseases, such as age-related macular degeneration (AMD), Stargardt's disease, retinitis pigmentosa (RP) and glaucoma. These diseases are all characterized by the degeneration of one or two retinal cell types that cannot regenerate spontaneously in humans. Aberrant retinal pigment epithelial (RPE) cells can be observed through optical coherence tomography (OCT) in AMD patients. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S13509462173012
Publisher Site
http://dx.doi.org/10.1016/j.preteyeres.2018.11.003DOI Listing
November 2018
11 Reads

Delineation of Novel Compound Heterozygous Variants in LTBP2 Associated with Juvenile Open Angle Glaucoma.

Genes (Basel) 2018 Oct 30;9(11). Epub 2018 Oct 30.

Department of Ophthalmology and Visual Sciences, University of Maryland School of Medicine, Baltimore, MD 21201, USA.

Juvenile open angle glaucoma (JOAG), which is an uncommon form of primary open angle glaucoma, is a clinically and genetically heterogeneous disorder. We report on a family with a recessively inherited form of JOAG. The proband has a superior and an inferior never fiber layer thinning in both the eyes and the nasal visual field (VF) defects in the left eye, which are clinical findings consistent with glaucomatous optic neuropathy. Read More

View Article

Download full-text PDF

Source
http://www.mdpi.com/2073-4425/9/11/527
Publisher Site
http://dx.doi.org/10.3390/genes9110527DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6266624PMC
October 2018
4 Reads

Efficacy and safety of ab interno trabeculectomy in juvenile open-angle glaucoma.

Can J Ophthalmol 2018 Oct 14;53(5):482-486. Epub 2018 Mar 14.

Department of Ophthalmology and Visual Sciences, University of Alberta, Edmonton, Alta.. Electronic address:

Objective: To determine the efficacy and safety of ab interno trabeculectomy with Trabectome in juvenile open-angle glaucoma (JOAG) patients.

Design: Prospective cohort study.

Methods: Evaluation of the 12-month results of 2 patient groups receiving ab interno trabeculectomy: group 1, eyes with no prior incisional surgery; group 2, eyes that had prior incisional cataract or glaucoma surgery. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S00084182173074
Publisher Site
http://dx.doi.org/10.1016/j.jcjo.2017.12.013DOI Listing
October 2018
10 Reads

Long-term results after primary intraocular lens implantation in children with juvenile idiopathic arthritis-associated uveitis.

Eur J Ophthalmol 2018 Sep 12:1120672118799623. Epub 2018 Sep 12.

1 St. Erik Eye Hospital, Stockholm, Sweden.

Purpose: To evaluate the long-term outcome after cataract surgery with primary intraocular lens implantation in children with juvenile idiopathic arthritis-associated uveitis.

Methods: The medical records of all 24 children (34 eyes) with chronic juvenile idiopathic arthritis-associated uveitis who underwent cataract surgery between 1990 and 2013 were reviewed retrospectively. Primary intraocular lens implantation was performed in all patients. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1120672118799623DOI Listing
September 2018
8 Reads

Ocular manifestations of Emanuel syndrome.

Am J Med Genet A 2018 Sep 4;176(9):1964-1967. Epub 2018 Sep 4.

Wills Eye Hospital, Philadelphia, Pennsylvania.

Emanuel syndrome is caused by a supernumerary der(22)t(11;22) and typically manifests with intellectual disability and craniofacial dysmorphism. Ocular abnormalities have infrequently been described. We report a 36-year-old man with severe intellectual disability, aphasia, and facial dysmorphism, with high myopia and juvenile open angle glaucoma (JOAG). Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1002/ajmg.a.40361
Publisher Site
http://dx.doi.org/10.1002/ajmg.a.40361DOI Listing
September 2018
14 Reads

Analysis of sequence alterations in patients with primary open-angle glaucoma of Saudi origin.

Clin Ophthalmol 2018 10;12:1413-1416. Epub 2018 Aug 10.

Glaucoma Research Chair, Department of Ophthalmology, College of Medicine, King Saud University, Riyadh, Saudi Arabia,

Cytochrome P450 Family 1 Subfamily B Member 1 (; OMIM# 601771) gene encodes one of the cytochrome P450 family of enzymes. mutations have been associated primarily with primary congenital glaucoma (PCG). Similar studies were reported in juvenile open-angle glaucoma, Rieger's and Peters anomalies. Read More

View Article

Download full-text PDF

Source
https://www.dovepress.com/analysis-of-cyp1b1-sequence-altera
Publisher Site
http://dx.doi.org/10.2147/OPTH.S169943DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6089601PMC
August 2018
9 Reads

New classification system for pediatric glaucoma: implications for clinical care and a research registry.

Curr Opin Ophthalmol 2018 Sep;29(5):385-394

Sidney Kimmel Medical College at Thomas Jefferson University.

Purpose Of Review: The Childhood Glaucoma Research Network (CGRN) has created a new classification system for childhood glaucoma that has become the first International Consensus Classification. The purpose of this review is to present this classification system and share its use to date.

Recent Findings: The diagnoses of the classification system include glaucoma and glaucoma suspect. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/ICU.0000000000000516DOI Listing
September 2018
35 Reads

Outcomes of non-infectious Paediatric uveitis in the era of biologic therapy.

Pediatr Rheumatol Online J 2018 Aug 6;16(1):51. Epub 2018 Aug 6.

University Hospitals Bristol NHS Foundation Trust, Bristol, UK.

Background: There is a paucity of data on the ocular outcomes in paediatric non-infectious uveitis since the introduction of the biologic agents. The purpose of this study was to outline the clinical characteristics of children with non-infectious uveitis and determine the visual outcomes and ocular complication rates in the modern era.

Methods: Children with non-infectious uveitis from January 2011 to December 2015 were identified. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12969-018-0266-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6080499PMC
August 2018
16 Reads

The treatment of refractory angle-closure glaucoma in a patient with X-linked juvenile retinoschisis.

Ophthalmic Genet 2018 Oct 6;39(5):625-627. Epub 2018 Aug 6.

a Moorfields Eye Hospital NHS Foundation Trust , London , United Kingdom.

X-Linked Retinoschisis (XLRS) is a common genetically determined form of macular degeneration affecting young males. XLRS is due to mutations in the RS1 gene located on chromosome Xp22 which codes for retinoschisin and is estimated to affect between 1:5000 to 1:20000 individuals worldwide. We report a case of refractory angle-closure glaucoma in a thirty-nine-year-old Caucasian man with atypical XLRS. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/13816810.2018.1490961DOI Listing
October 2018
12 Reads

STELLATE NONHEREDITARY IDIOPATHIC FOVEOMACULAR RETINOSCHISIS IN A PATIENT WITH MACULAR TELANGIECTASIA TYPE 2.

Retin Cases Brief Rep 2018 Jul 30. Epub 2018 Jul 30.

Department of Ophthalmology, Medical University of Graz, Graz, Austria.

Purpose: To present a case of unilateral stellate nonhereditary idiopathic foveomacular retinoschisis in a patient with macular telangiectasia (MacTel) Type 2.

Methods: Single-patient case report.

Results: A 61-year-old female white patient was referred to our clinic with metamorphopsia and reduction of visual acuity over a period of 2 months on her right eye. Read More

View Article

Download full-text PDF

Source
http://Insights.ovid.com/crossref?an=01271216-900000000-9877
Publisher Site
http://dx.doi.org/10.1097/ICB.0000000000000801DOI Listing
July 2018
2 Reads

Correlation of Crystallin Expression and RGC Susceptibility in Experimental Glaucoma Rats of Different Ages.

Curr Eye Res 2018 Oct 27;43(10):1267-1273. Epub 2018 Jul 27.

a Experimental Ophthalmology, Department of Ophthalmology , University Medical Center of the Johannes Gutenberg University Mainz , Mainz , Germany.

Purpose: Glaucoma is one of the leading causes of blindness worldwide with age being an important risk factor. However, the pathogenesis remains poorly understood. Aim of this study was to focus on age-dependent molecular changes in an experimental animal model of glaucoma. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/02713683.2018.1485950DOI Listing
October 2018

Juvenile Open Angle Glaucoma With Nonbullous Congenital Ichthyosiform Erythroderma.

J Glaucoma 2018 Nov;27(11):e180-e182

Schepens Eye Research Institute, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA.

Introduction: Glaucoma in patients with nonbullous congenital ichthyosiform erythroderma (NBCIE) is a rare entity that has not been described in a histologically confirmed case. We present a unique case of coexisting glaucoma, ichthyosis, and dwarfism that has not been previously described.

Methods: We present a case of NBCIE with glaucoma and dwarfism that presented to our outpatient department. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/IJG.0000000000001016DOI Listing
November 2018
2.430 Impact Factor

22q11.2 microduplication syndrome and juvenile glaucoma.

Ophthalmic Genet 2018 Aug 14;39(4):532-538. Epub 2018 Jun 14.

a Department of Ophthalmology, San Raffaele Scientific Institute , Vita-Salute University , Milan , Italy.

Background: 22q11.2 microduplication is a relatively recently recognized syndrome. Findings in affected individuals range from apparent normality to a wide variety of systemic and ocular conditions. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/13816810.2018.1484926DOI Listing
August 2018
4 Reads

Juvenile idiopathic arthritis-associated uveitis.

Best Pract Res Clin Rheumatol 2017 08 26;31(4):517-534. Epub 2018 Feb 26.

Department of Paediatric Rheumatology, Bristol Royal Hospital for Children, Upper Maudlin Street, Bristol, BS2 8BJ, UK. Electronic address:

Juvenile idiopathic arthritis (JIA) is the commonest rheumatic disease in children and JIA-associated uveitis its most frequent extra-articular manifestation. The uveitis is potentially sight-threatening and thus carries a considerable risk of morbidity with associated reduction in quality of life. The commonest form of uveitis seen in association with JIA is chronic anterior uveitis, which is almost always asymptomatic in the initial stages. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.berh.2018.01.002DOI Listing
August 2017
19 Reads

Pediatric Multiple Endocrine Neoplasia Type 2B: Clinicopathological Correlation of Perilimbal Mucosal Neuromas and Treatment of Secondary Open-Angle Glaucoma.

Ocul Oncol Pathol 2018 Apr 18;4(3):196-198. Epub 2017 Nov 18.

Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL, USA.

Ocular findings of multiple endocrine neoplasia type 2B (MEN 2B) include prominent corneal nerves, mucosal neuromas of the conjunctiva, glaucoma, and dry eyes. A 15-year-old girl with MEN 2B presents with advanced secondary open-angle glaucoma and bilateral perilimbal masses. High-resolution optical coherence tomography (HR-OCT) of the perilimbal lesions showed normal epithelial thickness and subepithelial lobular areas of mixed reflectivity, which correlates well with histopathologic findings of benign mucosal neuromas. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000484053DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5939668PMC
April 2018
5 Reads

The Association of Socioeconomic Status with Severity of Glaucoma and the Impacts of Both Factors on the Costs of Glaucoma Medications: A Cross-Sectional Study in West Bengal, India.

J Ocul Pharmacol Ther 2018 Jul/Aug;34(6):442-451. Epub 2018 May 15.

Department of Ophthalmology, Eye and Glaucoma Care, Vivekananda Institute of Medical Sciences (VIMS) , Kolkata, India .

Purpose: To evaluate the association of socioeconomic status (SES) with severity of glaucoma and assess the impacts of both SES and disease-severity factors on the costs of glaucoma medications among different glaucoma subtypes in West Bengal, India.

Methods: This cross-sectional study (2014-16) followed the treatment of 304 primary glaucoma patients for at least 18 months. The visual field based glaucoma staging was followed for stages 0-3; patients with field of vision <10° were categorized as stage 4 (end stage). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1089/jop.2017.0135DOI Listing
May 2018
4 Reads

Glaucoma therapy: preservative-free for all?

Authors:
John Thygesen

Clin Ophthalmol 2018 13;12:707-717. Epub 2018 Apr 13.

Department of Ophthalmology, Glaucoma Services in Copenhagen, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.

Preservatives used in topical glaucoma medications have a plethora of well-described toxic effects on the ocular surface. Such ocular toxicity is manifest clinically as ocular surface disease (OSD) and has been confirmed in epidemiologic, prospective clinical trials and studies in which patients are switched from preservative-added to preservative-free topical therapy. Such toxicity has implications not only for tolerability, but also for adherence and persistence with therapy that is known to be poor in glaucoma. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2147/OPTH.S150816DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5907786PMC
April 2018
1 Read

Iridogoniodysgenesis: A Challenging Case.

J Coll Physicians Surg Pak 2018 May;28(5):401-402

Department of Glaucoma Ophthalmology, Al-Shifa Trust Eye Hospital, Rawalpindi.

Iridogoniodysgenesis is a rare autosomal dominant disorder affecting anterior segment of the eye. Fifty percent cases of iridogoniodysgenesis have glaucoma, which is particularly difficult to manage. We report here a case of 40 years old man with this rare disorder, presenting to our glaucoma department. Read More

View Article

Download full-text PDF

Source
https://www.jcpsp.pk/data/view.php?id=2908&type=pdf&
Publisher Site
http://dx.doi.org/10.29271/jcpsp.2018.05.401DOI Listing
May 2018
6 Reads

Childhood glaucoma profile in Dakahelia, Egypt: a retrospective study.

Int J Ophthalmol 2018 18;11(4):674-680. Epub 2018 Apr 18.

Community and Public Health Department, Faculty of Medicine, Mansoura University, Mansoura 35516, Egypt.

Aim: To analyze childhood glaucoma regarding its demographics, presentations, different causes and surgical modalities used among patients in Dakahelia and to apply the Childhood Glaucoma Research Network (CGRN) classification retrospectively to evaluate its convenience.

Methods: A retrospective study in which the medical files of all glaucoma patients <16 years old presented to Mansoura Ophthalmic Center, Mansoura University from 2014 to 2017, were retrieved and analyzed. Collected data included: age, gender, laterality, visual acuity (VA), refraction, intraocular pressure (IOP), corneal diameter, cup-disc ratio, types and number of surgeries and antiglaucomatous drugs (AGD) at the first and last visit. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.18240/ijo.2018.04.23DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5902376PMC
April 2018
4 Reads

Multiplex Cytokine Analysis of Aqueous Humor in Juvenile Idiopathic Arthritis-Associated Anterior Uveitis With or Without Secondary Glaucoma.

Front Immunol 2018 5;9:708. Epub 2018 Apr 5.

Department of Ophthalmology and Ophtha-Laboratory at St. Franziskus-Hospital Münster, Münster, Germany.

Patients with juvenile idiopathic arthritis often develop chronic anterior uveitis (JIAU). JIAU patients possess a particularly high risk for developing secondary glaucoma when inflammatory inactivity has been achieved. By using multiplex bead assay analysis, we assessed levels of pro- and anti-inflammatory cytokines, chemokines, or metalloproteinases in the aqueous humor (AH) of patients with clinically inactive JIAU with (JIAUwG) or without secondary glaucoma (JIAUwoG), or from patients with senile cataract as controls. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fimmu.2018.00708DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5895756PMC
April 2018
12 Reads

A recurrent G367R mutation in associated with juvenile open angle glaucoma in a large Chinese family.

Int J Ophthalmol 2018 18;11(3):369-374. Epub 2018 Mar 18.

Department of Ophthalmology, the First Affiliated Hospital of Fujian Medical University, Fuzhou 350005, Fujian Province, China.

Aim: To identify the mutations of , , and in a large Chinese family affected by juvenile open angle glaucoma (JOAG).

Methods: Of 114 members of one family were recruited in this study. Blood samples from twelve members of this pedigree were collected for further research. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.18240/ijo.2018.03.04DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5861224PMC
March 2018
1 Read

Angle closure glaucoma in congenital ectropion uvea.

Am J Ophthalmol Case Rep 2018 Jun 9;10:215-220. Epub 2018 Mar 9.

Department of Ophthalmology and Visual Sciences, University of Michigan, United States.

Purpose: Congenital ectropion uvea is a rare anomaly, which is associated with open, but dysplastic iridocorneal angles that cause childhood glaucoma. Herein, we present 3 cases of angle-closure glaucoma in children with congenital ectropion uvea.

Observations: Three children were initially diagnosed with unilateral glaucoma secondary to congenital ectropion uvea at 7, 8 and 13 years of age. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S24519936173002
Publisher Site
http://dx.doi.org/10.1016/j.ajoc.2018.03.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5854872PMC
June 2018
6 Reads

Detection of mutations in MYOC, OPTN, NTF4, WDR36 and CYP1B1 in Chinese juvenile onset open-angle glaucoma using exome sequencing.

Sci Rep 2018 Mar 14;8(1):4498. Epub 2018 Mar 14.

Joint Shantou International Eye Center of Shantou University and The Chinese University of Hong Kong, Shantou, P. R. China.

Juvenile onset open-angle glaucoma (JOAG) affects patients before 40 years of age, causing high intraocular pressure and severe optic nerve damage. To expand the mutation spectrum of the causative genes in JOAG, with a view to identify novel disease-causing mutations, we investigated MYOC, OPTN, NTF4, WDR36 and CYP1B1 in a cohort of 67 unrelated Chinese JOAG patients. Whole exome sequencing was used to identify possible pathogenic mutations, which were further excluded in normal controls. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41598-018-22337-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5852028PMC
March 2018
8 Reads

Iris juvenile xanthogranuloma in an infant - spontaneous hyphema and secondary glaucoma.

Rom J Ophthalmol 2017 Jul-Sep;61(3):229-236

Opthalmology Clinic, "Sf. Spiridon" University Hospital, Iași, Romania.

Juvenile xanthogranuloma (JXG) is a benign histiocytic skin disorder mainly encountered during infancy and childhood. Although with multiple potential localizations, less than 1% of the cases exhibit ocular manifestations. Some of these might lead to serious complications, specifically, secondary glaucoma that can result in severe and blinding eye disease. Read More

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5710043PMC
July 2018
4 Reads

Case of Ab Interno Trabeculectomy in Juvenile Open-angle Glaucoma with 5-year Follow-up.

Can J Ophthalmol 2018 02 21;53(1):e39-e41. Epub 2017 Jul 21.

Department of Ophthalmology and Visual Sciences, University of Alberta, Alberta, Canada. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jcjo.2017.06.001DOI Listing
February 2018
6 Reads

Selective laser trabeculoplasty for primary open-angle glaucoma patients younger than 40 years.

Can J Ophthalmol 2018 02 25;53(1):81-85. Epub 2017 Sep 25.

Department of Biostatistics, All India Institute of Medical Sciences, New Delhi, India.

Objective: To evaluate the efficacy of selective laser trabeculoplasty (SLT) among patients with juvenile-onset primary open-angle glaucoma (JOAG).

Methods: Patients diagnosed with JOAG who were not controlled on medical therapy were offered a trial of SLT. The patients were followed up prospectively for 1, 3, 6, and 12 months postlaser to evaluate the efficacy of SLT as second-line therapy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jcjo.2017.07.023DOI Listing
February 2018
5 Reads

Visual Disability Among Juvenile Open-angle Glaucoma Patients.

J Glaucoma 2018 Apr;27(4):e87-e89

Dr Rajendra Prasad Centre for Ophthalmic Sciences.

Aim: Juvenile onset primary open-angle glaucoma (JOAG) unlike adult onset primary open-angle glaucoma presents with high intraocular pressure and diffuse visual field loss, which if left untreated leads to severe visual disability. The study aimed to evaluate the extent of visual disability among JOAG patients presenting to a tertiary eye care facility.

Methods: Visual acuity and perimetry records of unrelated JOAG patients presenting to our Glaucoma facility were analyzed. Read More

View Article

Download full-text PDF

Source
http://Insights.ovid.com/crossref?an=00061198-201804000-0001
Publisher Site
http://dx.doi.org/10.1097/IJG.0000000000000887DOI Listing
April 2018
12 Reads

Urrets-Zavalia Syndrome After Combined Trabeculotomy-Trabeculectomy Surgery.

J Glaucoma 2018 Apr;27(4):e80-e83

Department of Ophthalmology, University Medical Center, Mainz, Germany.

We report a case of a rare complication after trabeculotomy combined with a small trabeculectomy with mitomycin C in a young patient with juvenile glaucoma. The patient underwent uneventful surgery. However, postoperatively, he experienced a long-lasting hypotony with the need of 2 revision surgeries and 2 short episodes of high-intraocular pressure. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/IJG.0000000000000894DOI Listing
April 2018
3 Reads

One Eye Suffering from Ocular Decompression Retinopathy after Trabeculectomy in a Patient with Juvenile Open-Angle Glaucoma.

Chin Med J (Engl) 2018 Feb;131(3):366-367

Department of Ophthalmology, People's Hospital, Baoji, Shaanxi 721000, China.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4103/0366-6999.223861DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5798064PMC
February 2018
6 Reads

Systemic lupus erythematosus and ocular involvement: an overview.

Authors:
Rosanna Dammacco

Clin Exp Med 2018 May 14;18(2):135-149. Epub 2017 Dec 14.

Department of Basic Medical Sciences, Neurosciences and Sensory Organ, University of Bari Medical School, Clinica Oculistica, Policlinico, Piazza Giulio Cesare, 70124, Bari, Italy.

Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease of undefined etiology and with remarkably heterogeneous clinical features. Virtually any organ system can be affected, including the eye. SLE-related eye involvement can be diagnosed in approximately one-third of the patients and is usually indicative of disease activity. Read More

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s10238-017-0479-9
Publisher Site
http://dx.doi.org/10.1007/s10238-017-0479-9DOI Listing
May 2018
10 Reads

In Vivo Analysis of Angle Dysgenesis in Primary Congenital, Juvenile, and Adult-Onset Open Angle Glaucoma.

Invest Ophthalmol Vis Sci 2017 11;58(13):6000-6005

Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India.

Purpose: The purpose of this study was to comparatively evaluate angle dysgenesis in vivo, among congenital, juvenile, and adult-onset open angle glaucoma patients.

Methods: A cross-sectional evaluation of 96 glaucoma patients, 22 children with primary congenital glaucoma (PCG) old enough to cooperate for optical coherence tomography (OCT), 34 juvenile-onset open angle glaucoma (JOAG) patients, 40 adult-onset primary open angle glaucoma (POAG), and 30 healthy subjects, was carried out using high-resolution anterior segment spectral domain (SD)-OCT. Subgroup analysis was done for presence/ absence of angle dysgenesis as defined by presence of abnormal tissue/hyperreflective membrane within angle recess and/or absence of Schlemm's canal (SC). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1167/iovs.17-22695DOI Listing
November 2017
7 Reads

Role of CYP1B1, p.E229K and p.R368H mutations among 120 families with sporadic juvenile onset open-angle glaucoma.

Graefes Arch Clin Exp Ophthalmol 2018 Feb 22;256(2):355-362. Epub 2017 Nov 22.

Department of Anatomy, All India Institute of Medical Sciences, New Delhi, India.

Background: To determine the frequency of CYP1B1 p.E229K and p.R368H, gene mutations in a cohort of sporadic juvenile onset open-angle glaucoma (JOAG) patients and to evaluate their genotype/phenotype correlation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00417-017-3853-0DOI Listing
February 2018
9 Reads

Update on the Treatment of Uveitis in Patients with Juvenile Idiopathic Arthritis: A Review.

Adv Ther 2017 12 16;34(12):2558-2565. Epub 2017 Nov 16.

1st and 3rd University Departments of Ophthalmology, Aristotle University of Thessaloniki, Thessaloniki, Greece.

Chronic uveitis is a common extra-articular manifestation of juvenile idiopathic arthritis. The classic clinical picture is one of chronic anterior uveitis, which usually remains asymptomatic until ocular complications arise. The risk of uveitis is increased in girls with an early onset of oligoarthritis and positive antinuclear antibodies. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12325-017-0635-3DOI Listing
December 2017
5 Reads

An Application of NGS for Gene in Taiwanese Patients with Juvenile-Onset Open-Angle Glaucoma.

Int J Med Sci 2017 20;14(12):1251-1256. Epub 2017 Sep 20.

Department of Ophthalmology, Chi-Mei Medical Center, Liou-Ying, Tainan, Taiwan.

Primary open-angle glaucoma (POAG) is one of the most important disease in ophthalmology with high prevalence and risk of irreversible blindness. If diagnosed before the age of 35, it is usually categorized as juvenile open-angle glaucoma (JOAG). The gene is reckoned as one of the major causative genes of POAG, and had been studied to be related to the pathogenesis of POAG in the literature. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.7150/ijms.20729DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5666558PMC
June 2018
3 Reads

Uveitis and Juvenile Psoriatic Arthritis or Psoriasis.

Am J Ophthalmol 2018 Jan 31;185:68-74. Epub 2017 Oct 31.

Department of Ophthalmology, Casey Eye Institute, Oregon Health & Science University, Portland, Oregon; Department of Medicine, Oregon Health & Science University, Portland, Oregon; Legacy Devers Eye Institute, Portland, Oregon. Electronic address:

Purpose: To describe the phenotype of the uveitis that accompanies juvenile psoriatic arthritis or psoriasis.

Design: Observational case series.

Methods: Setting: Two university-based referral clinics: 1 in England, 1 in the United States. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ajo.2017.10.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5819354PMC
January 2018
10 Reads

Spectrum of Eye Disorders Seen in a Pediatric Eye Clinic South East Nigeria.

Niger J Surg 2017 Jul-Dec;23(2):125-129

Department of Paediatrics, Federal Medical Centre, Owerri, Nigeria.

Purpose: This study aims to determine the prevalence, pattern, and time of presentation for the ocular disorders seen among children attending a pediatric eye clinic in Nigeria.

Materials And Methods: A retrospective chart review of all first-time patients at a pediatric eye clinic, within 2005-2007 was carried out. Data on cohort demographics, duration of illness before the presentation, and types of ocular disorders were collected and analyzed. Read More

View Article

Download full-text PDF

Source
http://www.nigerianjsurg.com/text.asp?2017/23/2/125/215902
Publisher Site
http://dx.doi.org/10.4103/njs.NJS_37_16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5649428PMC
November 2017
7 Reads

Determination Of Association Of Pigmentary Glaucoma With Pigment Dispersion Syndrome.

J Ayub Med Coll Abbottabad 2017 Jul-Sep;29(3):412-414

Department of Ophthalmology, Chandka Medical College, Larkana, Sindh, Pakistan.

Background: Pigment Dispersion Syndrome (PDS) is an autosomal dominant disorder of white males between 20 to 40 years of age characterized by deposition of pigment on the lens, zonules of lens, trabecular meshwork and corneal endothelium (Krukenberg's spindle) in addition to radial, spoke like transillumination defects in the mid peripheral iris. This study was conducted to determine the frequency of occurrence of Pigmentary Glaucoma in patients with Pigment Dispersion Syndrome (PDS).

Methods: This longitudinal follow up study included patients presenting with Krukenberg's spindle on the endothelial side of cornea and pigmentation of angle of anterior chamber seen on slit lamp examination and gonioscopy. Read More

View Article

Download full-text PDF

Source
October 2017
9 Reads

Anteriorization of the Normally Acting Inferior Oblique Muscles to Treat Dissociated Vertical Deviation Associated With Juvenile Glaucoma.

J Pediatr Ophthalmol Strabismus 2017 Oct 9;54:e63-e66. Epub 2017 Oct 9.

A case of dissociated vertical deviation, ptosis, and juvenile glaucoma is described. J deformity anteriorization of the normally acting inferior oblique muscles was chosen to preserve the superior fornix for glaucoma surgeries by avoiding superior rectus recession and to prevent narrowing of the palpebral fissure by avoiding an inferior rectus tuck. [J Pediatr Ophthalmol Strabismus. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3928/01913913-20170907-05DOI Listing
October 2017
6 Reads

Genetic Testing in Pediatric Ophthalmology.

Indian J Pediatr 2018 03 2;85(3):228-236. Epub 2017 Oct 2.

Institute of Medical Genetics and Genomics, Sir Ganga Ram Hospital, New Delhi, 110060, India.

The authors review the utility of genetic testing in ophthalmic disorders - precise diagnosis, accurate prognosis, genetic counseling, prenatal diagnosis, and entry into gene-specific therapeutic trials. The prerequisites for a successful outcome of a genetic test are an accurate clinical diagnosis, a careful family history that guides which genes to study, and genetic counseling (both pre-test and post-test). The common eye disorders for which genetic testing is commonly requested are briefly discussed - anophthalmia, microphthalmia, coloboma, anterior segment dysgenesis, corneal dystrophies, cataracts, optic atrophy, congenital glaucoma, congenital amaurosis, retinitis pigmentosa, color blindness, juvenile retinoshisis, retinoblastoma etc. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s12098-017-2453-7DOI Listing
March 2018
4 Reads

Patterns of Intermediate Uveitis in Children Presenting at a Tertiary Eye Care Center in South India.

Middle East Afr J Ophthalmol 2017 Apr-Jun;24(2):94-99

Department of Uveitis and Ocular Pathology, Sankara Nethralaya, Chennai, Tamil Nadu, India.

Purpose: To study the patterns of intermediate uveitis in the pediatric age group in a referral eye care center in South India.

Methods: This is a study of twenty consecutive patients under 16 years of age with intermediate uveitis, conducted at a tertiary referral center. Numerous variables were assessed, including age and gender distribution, laboratory data, the presence of systemic diseases, onset and course of ocular inflammation, clinical features, their complications, therapeutic strategies with their outcomes, remission, final visual acuity (VA), and characteristics associated with poor visual outcome. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4103/meajo.MEAJO_264_15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5598310PMC
October 2017
21 Reads

Outcomes of severe uveitic glaucoma treated with Baerveldt implant: can blindness be prevented?

Acta Ophthalmol 2018 Feb 18;96(1):24-30. Epub 2017 Sep 18.

Maastricht University Medical Centre, University Eye Clinic, Maastricht, The Netherlands.

Purpose: To evaluate long-term outcomes on efficacy and safety of severe uveitic glaucoma treated with a Baerveldt glaucoma implant (BGI).

Methods: A retrospective study of 47 eyes of 47 patients with uveitic glaucoma treated by a BGI between September 2002 and September 2015. Main outcome measures were intraocular pressure (IOP), number of glaucoma medications, course of the uveitis, visual acuity (VA) and complications. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/aos.13489DOI Listing
February 2018
18 Reads

[Wolfram syndrome and juvenile glaucoma: Case report].

J Fr Ophtalmol 2017 Oct 15;40(8):e297-e298. Epub 2017 Sep 15.

CHU d'Angers, 4, rue Larrey, 49100 Angers, France.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jfo.2017.05.006DOI Listing
October 2017
4 Reads