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Biol Blood Marrow Transplant 2018 Dec 3. Epub 2018 Dec 3.

Department of Ophthalmology, Hospital Universitario Puerta de Hierro, Madrid, Spain.

Non-graft-versus-host disease (non-GVHD) ocular complications are generally uncommon after hematopoietic cell transplantation (HCT), but can cause prolonged morbidity affecting activities of daily living and quality of life. Here we provide an expert review of non-GVHD ocular complications in a collaboration between transplant physicians and ophthalmologists through the Late Effects and Quality of Life Working Committee of the Center for International Blood and Marrow Transplant Research and the Transplant Complications Working Party of the European Society of Blood and Marrow Transplantation. Complications discussed in this review include cataracts, glaucoma, ocular infections, ocular involvement with malignancy, ischemic microvascular retinopathy, central retinal vein occlusion, retinal hemorrhage, retinal detachment and ocular toxicities associated with medications. Read More

MMWR Morb Mortal Wkly Rep 2018 Dec 7;67(48):1347-1349. Epub 2018 Dec 7.

On June 22, 2017, the Los Angeles County Department of Public Health (LAC DPH) was notified of seven patients who were seen at an eye care clinic on June 8, 2017, and later developed symptoms of epidemic keratoconjunctivitis (EKC). EKC is a contagious, severe form of viral conjunctivitis that can cause pain and blurred vision for up to 4 weeks (1). LAC DPH conducted an investigation, which identified 17 patients with EKC, including 15 who had visited the optometry clinic and two who were household contacts of clinic patients. Read More

Ophthalmic Epidemiol 2018 Dec 6:1-7. Epub 2018 Dec 6.

a College of Medicine, Enugu State University of Technology(ESUT), Enugu State University of Science and Technology (ESUT) Teaching Hospital Parklane , The Eye Specialists Hospital (TESH) , Enugu , Nigeria.

Purpose: To determine uptake, adherence and influencing factors to follow-up care by newly diagnosed glaucoma patients from free eye screening exercise.

Methods: The study was a cross-sectional survey of newly diagnosed glaucoma patients during free eye screenings carried out in March and October, 2016 in Enugu, Nigeria. Data on participants were analyzed after a minimum of 6 months from the screening for uptake and adherence to follow-up care. Read More

J Glaucoma 2018 Dec 5. Epub 2018 Dec 5.

Hospital das Clínicas, Federal University of Pernambuco (HC - UFPE), Recife, Pernambuco, Brazil.

Purpose: To identify variants in the CYP1B1 gene in northeastern Brazilian patients with PCG and possible genotype-phenotype correlations.

Materials And Methods: This is a cross-sectional observational study of 17 non-related patients with PCG, performed at the Altino Ventura Foundation, Recife, Brazil, between December 2017 and February 2018. All patients underwent an examination, including gathering information from their medical records, slit lamp examination, fundoscopy, tonography, and measuring corneal diameter and thickness. Read More

Ophthalmologe 2018 Dec 5. Epub 2018 Dec 5.

Augenklinik und Poliklinik, Universitätsmedizin Mainz, Langenbeckstr. 1, 55116, Mainz, Deutschland.

The treatment of congenital glaucoma requires special expertise and often novel surgical approaches. The combined use of a XEN and a Baerveldt implant is an alternative to conventional tube implants and may be less harmful for long-term corneal endothelial damage. If this technique does not provide sufficient long-term control of intraorbital pressure (IOP), a direct implantation of the Baerveldt tube can be easily performed in a second intervention. Read More

Am J Ophthalmol Case Rep 2019 Mar 10;13:22-24. Epub 2018 Nov 10.

Department of Ophthalmology, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Pl, New York, NY, USA.

Purpose: We report an update on a recently published case of uncontrolled hypertension secondary to immunoglobulin A (IgA) nephropathy resulting in massive bilateral retinal and choroidal infarction.

Observations: In our previous report, we presented a 30-year old female with end-stage renal disease who complained of painless vision loss after many missed hemodialysis. The patient was found to be in hypertensive crisis resulting in massive retinal and choroidal infarction with severe vision loss in both eyes. Read More

BMJ Open Ophthalmol 2018 31;3(1):e000165. Epub 2018 Oct 31.

Glaucoma and Neuro-Ophthalmology Department, FISABIO Oftalmologia, Valencia, Spain.

Objective: To compare prospectively intraocular pressure (IOP) results after deep sclerectomy (DS) using a topical short-term corticosteroid treatment (STCT, 1  month) versus a topical long-term and intense corticosteroid treatment (LTCT, 6 months) in a two2  year-follow-up.

Methods: Patients with medically uncontrolled open angle glaucoma were prospectively recruited and underwent a DS.

Results: We operated 45 eyes of 45 patients, 22 in STCT group and 23 in LTCT group. Read More

Transl Vis Sci Technol 2018 Nov 30;7(6):14. Epub 2018 Nov 30.

Jules Stein Eye Institute, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.

Purpose: To develop a method to measure the rate of glaucomatous visual field (VF) deterioration and to identify fast progressors.

Methods: Retrospective, longitudinal, observational study of 8486 eyes of 4610 glaucomatous patients with ≥6 VFs and ≥3 years of follow-up. A Glaucoma Rate Index (GRI) was calculated. Read More

Transl Vis Sci Technol 2018 Nov 30;7(6):13. Epub 2018 Nov 30.

Institut Catalá de Retina, Universitat Internacional de Catalunya, Barcelona, Spain.

Purpose: To evaluate two glaucoma diagnostic calculators (GDC) in a group of eyes with preperimetric glaucoma (PPG).

Methods: All eyes ( = 265) included in this study had ocular hypertension with normal visual fields (VFs) on repeated VF tests. PPG was defined as progression in the Guided Progression Analysis software from Cirrus-optical coherence tomography (GPA-OCT). Read More

Genet Res Int 2018 1;2018:2148056. Epub 2018 Nov 1.

Glaucoma Research Chair, Department of Ophthalmology, College of Medicine, King Saud University, Riyadh, Saudi Arabia.

A case-control genetic association study was performed to investigate whether variant rs7916697 in (), which has been previously reported to be associated with optic disc parameters and primary open angle glaucoma (POAG) in different ethnic groups, is a risk factor for POAG or any of its clinical phenotypes in a Saudi cohort. Genotyping of rs7916697 (G>A) variant was performed in 186 unrelated POAG cases and 171 unrelated nonglaucomatous controls of Saudi origin using real-time Taq-Man® assay. Genotypic and allelic association with POAG and its related clinical indices were evaluated. Read More

Clin Ophthalmol 2018 13;12:2313. Epub 2018 Nov 13.

[This corrects the article on p. 1819 in vol. 10, PMID: 27698551. Read More

Eye (Lond) 2018 Dec 5. Epub 2018 Dec 5.

Jasti V Ramanamma Children's Eye Care Centre, L V Prasad Eye Institute, Hyderabad, India.

Purpose: To evaluate the health-related quality of life (HRQoL) of children operated for primary congenital glaucoma (PCG) using the Kidscreen-27 questionnaire.

Methods: A total of 121 children (mean age, 11.8 years; SD, 2. Read More

Eye (Lond) 2018 Dec 5. Epub 2018 Dec 5.

Department of Ophthalmology, Rabin Medical Center, Petach Tikva, Israel.

Purpose: To assess Descemet's membrane endothelial keratoplasty (DMEK) without performing a peripheral iridotomy (PI) prior to or during surgery ("PI-less DMEK").

Materials And Methods: This retrospective study included consecutive patients that underwent PI-less DMEK by a single surgeon (E.L) between February 2016 and February 2017 at the Rabin Medical Center, a Tertiary Hospital. Read More

Rev Prat 2016 Nov;67(9):1001-1008

Service d'ophtalmologie du Nouvel Hôpital civil, Hôpitaux universitaires de Strasbourg, Strasbourg, France.

Diabetic retinopathy. Diabetic retinopathy (DR) is a disease whose screening actually can change the functional prognosis for the patients. It makes blindness avoidable. Read More

PLoS One 2018 3;13(12):e0208420. Epub 2018 Dec 3.

Department of Ophthalmology, Otorhinolaryngology and Head & Neck Surgery, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, São Paulo, Brazil.

Purpose: Dry Eye Disease (DED) is part of several conditions, including Sjögren's syndrome (SS) and no single test to diagnosis DED. The present study intends to evaluate whether a set of signs and symptoms of DED can distinguish: a) SS from other non-overlapping systemic diseases related to DED; b) primary and secondary SS.

Methods: 182 consecutive patients with DED were evaluated under five groups: SS, graft-versus-host disease (GVHD), Graves' orbitopathy (GO), diabetes mellitus (DM), glaucoma under treatment with benzalkonium chloride medications (BAK). Read More

Ophthalmologe 2018 Nov 30. Epub 2018 Nov 30.

Klinik und Poliklinik für Augenheilkunde, Klinikum der Universität Regensburg, Franz-Josef-Strauß-Allee 11, 93053, Regensburg, Deutschland.

Background: Glaucoma due to elevated episcleral venous pressure is a rare and difficult to treat form of secondary open angle glaucoma.

Objective: The pathophysiology, clinical findings, differential diagnosis and treatment options are discussed. Radius-Maumenee syndrome, Sturge-Weber syndrome and carotid-cavernous sinus fistulas are covered in particular. Read More

Oman J Ophthalmol 2018 Sep-Dec;11(3):241-247

Senior Resident, Department of Ophthalmology, AIIMS, Raipur (CG), Chhattisgarh, India.

Purpose: An assessment of variation in Macular Volume and RNFL Thickness in myopes using OCT, and their significance for early diagnosis of Primary Open Angle Glaucoma(POAG).

Materials And Method: Total of 122 eyes of 61 Indian Myopic subjects of both sex and various age groups underwent retinal nerve fiber layer thickness, macular volume in 6mm analysis by Rtvue Avanti SD-OCT, Optovue Technology V6.1. Read More

Oman J Ophthalmol 2018 Sep-Dec;11(3):220-226

Department of Ophthalmology, Himalayan Institute of Medical Sciences, Swami Rama Himalayan University, Jolly Grant, Dehradun, Uttarakhand, India.

Background: Glaucoma is the leading cause of blindness after penetrating keratoplasty (PK) and its early diagnosis and management is mandatory to salvage the graft.

Aims: This study aimed to evaluate the incidence and risk factors for post penetrating keratoplasty glaucoma (PKG).

Methods: Data of 155 eyes of 155 patients were reviewed retrospectively who underwent PK from March 2013 to February 2016. Read More

Oman J Ophthalmol 2018 Sep-Dec;11(3):195-199

Glaucoma Service, Wills Eye Hospital, Philadelphia, PA, USA.

Glaucoma is a chronic, progressive disease of the optic nerve which is relatively uncommon in childbearing age; however, its management is a real challenge. Although the intraocular pressure decreases in pregnancy, many glaucoma patients continue to require treatment. In addition to the side effects, antiglaucoma medications on the mother, the possible side effects of drugs on the fetus must be taken into account. Read More

Can J Ophthalmol 2018 Dec 3;53(6):588-594. Epub 2018 Apr 3.

Department of Ophthalmology and Visual Sciences, University of Alberta, Edmonton, Alta.. Electronic address:

Objective: To compare the efficacy and safety of ab interno trabeculectomy with the Trabectome combined with cataract surgery (phaco-AIT) versus Trabeculectomy with mitomycin C combined with cataract surgery (phaco-Trab) in open-angle glaucoma.

Methods: A prospective randomized controlled trial with a single surgeon and surgical center was undertaken. Patients were recruited from July 2009 to October 2014. Read More

Can J Ophthalmol 2018 Dec 2;53(6):574-579. Epub 2018 Apr 2.

Moorfields Eye Hospital NHS Foundation Trust, London, United Kingdom. Electronic address:

Objective: To describe conjunctival epithelial overgrowth of the cornea after surgery for glaucoma.

Methods: This is a retrospective case series (setting: Moorfields Eye Hospital). Fourteen eyes of 13 patients with suspected limbal stem cell deficiency (LSCD) and corneal conjunctivalization after glaucoma drainage surgery. Read More

Top Companion Anim Med 2018 Dec 7;33(4):109-113. Epub 2018 Sep 7.

Department of Veterinary Medicine/Center for Investigation Vasco da Gama (DMV/CIVG), University School Vasco da Gama, 3020-210 Coimbra, Portugal; LAQV, REQUIMTE, Laboratory of Bromatology and Pharmacognosy, Faculty of Pharmacy, University of Coimbra, 3000-548 Coimbra, Portugal. Electronic address:

Cataracts are among the most common ocular diseases, and are a leading cause of vision loss in humans and dogs. Jack Russell Terriers (JRT) and Labrador Retrievers (LR) are among the most popular canine breeds in the United Kingdom, and also among the most affected by cataracts. This study aimed to analyze the clinical features and the surgical outcome of cataracts in JRT and LR in an ophthalmologic reference Veterinary Hospital in the United Kingdom. Read More

Am J Ophthalmol 2018 Nov 28. Epub 2018 Nov 28.

Singapore Eye Research Institute, Singapore National Eye Centre. Electronic address:

Purpose: To evaluate the diagnostic performance of swept-source optical coherence tomography (SS-OCT, CASIA SS-1000, Tomey Corporation, Nagoya, Japan) for angle closure detection, in comparison with gonioscopy in a community setting.

Design: Reliability analysis.

Methods: A total of 2027 phakic subjects aged ≥50 years, with no previous history of glaucoma, laser (including peripheral iridotomy), intraocular surgery or ocular trauma, were consecutively recruited from a community polyclinic in Singapore. Read More

Am J Ophthalmol 2018 Nov 28. Epub 2018 Nov 28.

Netherlands Institute for Innovative Ocular Surgery (NIIOS), Rotterdam, The Netherlands; Melles Cornea Clinic Rotterdam, The Netherlands; Amnitrans Eye Bank Rotterdam, The Netherlands; NIIOS-USA, San Diego, USA. Electronic address:

Purpose: To evaluate the feasibility and clinical outcomes of Descemet membrane endothelial keratoplasty (DMEK) in eyes with a glaucoma drainage device (GDD).

Design: Retrospective, interventional case series.

Methods: Clinical outcomes of 23 DMEK procedures for bullous keratopathy (52%), failed previous transplant (39%) or Fuchs endothelial corneal dystrophy (9%) in 20 eyes (19 patients) with a GDD were retrospectively analyzed at two tertiary referral centers. Read More

Acta Clin Belg 2018 Dec 3:1-5. Epub 2018 Dec 3.

a Department of Pediatrics, Division of Pediatric Nephrology and Rheumatology , Ghent University Hospital , Ghent , Belgium.

We describe a boy who presented with neonatal hypotonia, followed by delayed motor development and growth impairment. Further evaluation revealed rickets caused by proximal renal tubular dysfunction. At age 3, the boy exhibited dysmorphic features and bilateral cataract. Read More

PLoS One 2018 5;13(12):e0207784. Epub 2018 Dec 5.

Glaucoma Service, Department of Ophthalmology, University of Campinas, Campinas, São Paulo, Brazil.

Purpose: To test the ability of machine learning classifiers (MLCs) using optical coherence tomography (OCT) and standard automated perimetry (SAP) parameters to discriminate between healthy and glaucomatous individuals, and to compare it to the diagnostic ability of the combined structure-function index (CSFI), general ophthalmologists and glaucoma specialists.

Design: Cross-sectional prospective study.

Methods: Fifty eight eyes of 58 patients with early to moderate glaucoma (median value of the mean deviation = -3. Read More

PLoS One 2018 5;13(12):e0206684. Epub 2018 Dec 5.

Flinders University, Department of Ophthalmology, South Australia, Australia.

Purpose: The ganglion cell analysis (GCA) of the CIRRUSTM HD-OCT (Carl Zeiss, Meditec; Dublin, CA) provides measurement of the macular ganglion cell-inner plexiform layer (GCIPL) thickness. This study determined the frequency of scan artefacts and errors in GCIPL imaging in individuals undergoing HD-OCT surveillance for glaucoma.

Method: A total of 1439 eyes from 721 subjects enrolled in a prospective study assessing predictors of glaucoma progression underwent macular GCIPL imaging with the CIRRUS HD-OCT at recruitment. Read More

Invest Ophthalmol Vis Sci 2018 Dec;59(15):5745-5751

Department of Ophthalmology, Osaka University Graduate School of Medicine, Yamadaoka, Japan.

Purpose: To determine the relevance of epiretinal membranes (ERMs) in primary open-angle glaucoma (POAG) and potential risk for glaucoma severity.

Methods: Sixty eyes of 30 patients with POAG who had a unilateral ERM were analyzed; 60 nonglaucomatous eyes of 30 patients with a unilateral ERM also were recruited in this institutional cross-sectional study. Patients underwent swept-source (SS) optical coherence tomography (OCT) imaging and visual field testing. Read More

J Cell Physiol 2018 Dec 4. Epub 2018 Dec 4.

Department of Ophthalmology, First Affiliated Hospital, Harbin Medical University, Harbin, China.

Retinal neovascularization occurs in various ocular disorders including proliferative diabetic retinopathy and secondary neovascular glaucoma, resulting in blindness. This paper aims to investigate the effect of microRNA-141-3p (miR-141-3p) on retinal neovascularization and retinal ganglion cells (RGCs) in glaucoma mice through the Docking protein 5 (DOK5)-mediated mitogen-activated protein kinase (MAPK) signaling pathway. Chip retrieval and difference analysis were used for the potential mechanism of miR-141-3p on glaucoma. Read More

J Ophthalmol 2018 31;2018:6128470. Epub 2018 Oct 31.

Department of Ophthalmology, Zhongnan Hospital, Wuhan University, Wuhan, China.

Purpose: Glaucoma is the leading cause of irreversible blindness throughout the world. The pathogenesis of glaucoma is complex, and neuroprotection is a crucial aspect of therapy. High concentrations of extracellular glutamate are toxic to the optic nerve. Read More

Nan Fang Yi Ke Da Xue Xue Bao 2018 Nov;38(11):1389-1394

Center of Myopia, Affiliated Hospital of Inner Mongolia Medical University, Hohhot 010050, China.

Objective: To study the anti- scarring effect of rapamycin in rabbits receiving glaucoma filtering surgery.

Methods: Ninety-six Chinchilla rabbits were randomized equally into 3 rapamycin treatment groups and one control group. All the rabbits underwent trabeculectomy, after which the rabbits in the 3 rapamycin groups were treated with eye drops containing 1%, 3%, or 5% rapamycin in the operated eyes, and those in the control groups were given castor oil 4 times a day. Read More

Surv Ophthalmol 2019 Jan - Feb;64(1):101

Int J Mol Sci 2018 Dec 3;19(12). Epub 2018 Dec 3.

Department of Experimental and Translational Ophthalmology, University Medical Center, Johannes Gutenberg University, 55131 Mainz, Germany.

Proper sample preparation protocols represent a critical step for liquid chromatography-mass spectrometry (LC-MS)-based proteomic study designs and influence the speed, performance and automation of high-throughput data acquisition. The main objective of this study was to compare two commercial solid-phase extraction (SPE)-based sample preparation protocols (comprising SOLAµ HRP SPE spin plates from Thermo Fisher Scientific and ZIPTIP C18 pipette tips from Merck Millipore) for analytical performance, reproducibility, and analysis speed. The house swine represents a promising animal model for studying human eye diseases including glaucoma and provides excellent requirements for the qualitative and quantitative MS-based comparison in terms of ocular proteomics. Read More

Rev Prat 2016 May;66(5):508-513

Institut du glaucome, hôpital Saint-Joseph, Paris, France.

Glaucomas treatment. Glaucoma is the first cause of blindness in Europe. The purposes of its treatment are lowering intraocular pressure (IOP), but also getting a good patient compliance with a good tolerance and a good ratio cost/effectiveness. Read More

Rev Prat 2016 May;66(5):505-507

Institut du glaucome, hôpital Saint-Joseph, Paris, France.

The role of gp in the management of glaucoma. Despite the fact that glaucomas in mainly followed by an ophthalmologist, the GPs should have a good knowledge about this disease and especially about vascular and general risk factors. Primary open angle glaucoma (POAG) is a multifactorial disease characterized by progressive retinal ganglion cell death and visual field loss. Read More

Rev Prat 2016 May;66(5):500-504

Institut du glaucome, hôpital Saint-Joseph, Paris, France.

Primary open-angle glaucoma. Primary open-angle glaucoma is a progressive optic neuropathy with characteristic morphological changes at the optic nerve head and retinal fiber layer in the absence of other ocular disease. The diagnosis is difficult and based on conjunction of elevated intraocular pressure (inconstant) loss of retinal fiber layer and visual field defects. Read More

Rev Prat 2016 May;66(5):496-498

Institut du glaucome, hôpital Saint-Joseph, Paris, France.

Glaucoma Screening And Prevention. Glaucoma screening is a very important health problem, as it is a frequent desease, and can lead to blindness when not treated (3rd cause of blindness worldwide). When diagnosed early, glaucoma can be treated, allowing to avoid blindness in a majority of patients. Read More

Invest Ophthalmol Vis Sci 2018 Dec;59(15):5717-5725

Department of Ophthalmology, University of Tokyo, Tokyo, Japan.

Purpose: The purpose of this study was to evaluate the rate of visual field (VF) loss in primary open-angle glaucoma (POAG) and primary angle-closure glaucoma (PACG).

Methods: Four hundred forty eyes of 282 patients with POAG (aged 53.4 ± 12. Read More

Leuk Res 2018 Nov 29;76:24-28. Epub 2018 Nov 29.

Department of Medicine, Federal University of Sergipe, Aracaju, Sergipe, Brazil.

Objective: To characterize ocular manifestations (OM) of pediatric patients treating for acute lymphoblastic leukemia (ALL) and to evaluate whether they are associated with well-described predictive risk factors for relapse, protocol (1999 or 2009), gender and cerebrospinal fluid infiltration.

Methods: A prospective cohort study was conducted in children and adolescents with ALL from January 2013 to December 2017. The patients underwent ophthalmologic evaluations before starting treatment (D0), on the eighth day (D8), at the 28th day (D28), and at six months (D6 months). Read More

J Pharm Sci 2018 Dec 1. Epub 2018 Dec 1.

The Leicester School of Pharmacy, De Montfort University, Leicester, LE1 1BH, UK. Electronic address:

This manuscript reports on Electrohydrodynamic Atomisation (EHDA) to engineer on-demand novel coatings for ocular contact lenses. A formulation approach was adopted to modulate the release of timolol maleate (TM) using chitosan and borneol. Polymers polyvinylpyrrolidone (PVP) and poly (N-isopropylacrylamide) (PNIPAM) were utilised to encapsulate TM and were electrically atomised to produce optimised, stationary contact lens coatings. Read More

Curr Eye Res 2018 Dec 4. Epub 2018 Dec 4.

a Department of Ophthalmology, Clinical Medical College , Yangzhou University , Yangzhou , Jiangsu Province , China.

Background: To determine the involvement of MicroRNA-200b (miR-200b) in human Tenon's fibroblasts (HTFs) fibrosis.

Methods: HTFs were treated with 10 ng/ml TGF-β1 for 24 hours. Expression of α-smooth muscle actin (α-SMA), Fibronectin and Collagen1A1 (COL1A1) was assessed by western blot and immunofluorescence. Read More

Chin Med J (Engl) 2018 Dec;131(23):2852-2859

Department of Glaucoma, State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangzhou, Guangdong 510060, China.

Objective: In previous decades, glaucoma has been primarily attributed to elevated intraocular pressure (IOP), but this has gradually been replaced by the development of optic neuropathy as the central concept of glaucoma in developed countries. However, there still remain strong controversies in the definition of glaucoma in China. In this current review, we are going to discuss these controversies and elaborate on the historical transitions of the definition of glaucoma both in China and developed countries. Read More

Am J Ophthalmol Case Rep 2019 Mar 14;13:32-33. Epub 2018 Nov 14.

King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia.

Purpose: To describe a child with primary congenital glaucoma found to have pigment tissue proliferation in the angle following multiple applications of trans-scleral cyclophotocoagulation.

Observations: During examination under anaesthesia, a 4-year-old girl was found to have pigmented tissue overlying the trabecular meshwork. Anterior segment ocular coherence tomography confirmed mounds of abnormal tissue in the angle. Read More

Transl Vis Sci Technol 2018 Nov 27;7(6):12. Epub 2018 Nov 27.

Department of Ophthalmology, Glaucoma Service, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA, USA.

Purpose: To evaluate the effects of age, race, and ethnicity on the optic nerve and peripapillary retina using spectral-domain optical coherence tomography (SD-OCT) three-dimensional (3D) volume scans in normal subjects.

Methods: This is a cross-sectional study performed at a single institution in Boston. All patients received retinal nerve fiber layer (RNFL) scans and an optic nerve 3D volume scan. Read More

Clin Ophthalmol 2018 8;12:2285-2296. Epub 2018 Nov 8.

Department of Bioengineering, University of Washington, Seattle, WA, USA.

Purpose: To quantify peripapillary microvasculature within the retinal nerve fiber layer (RNFL) in primary open-angle glaucoma (POAG) and normal eyes, determine association of perfusion parameters with structural and functional measures, and report diagnostic accuracy of perfusion parameters.

Patients And Methods: POAG and normal patients underwent 6×6 mm optic nerve head scans (Angioplex optical coherence tomography angiography [OCTA]; Cirrus HD-OCT 5000) and Humphrey Field Analyzer II-i 24-2 visual field (VF) testing. Prototype software performed semiautomatic segmentation to create RNFL en face images and quantified vessel area density (VAD), vessel skeleton density (VSD), and vessel complexity index (VCI) in the optic nerve head globally and focally. Read More

J Cataract Refract Surg 2018 Nov 30. Epub 2018 Nov 30.

From the Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India.

The treatment of choice for cases of corneal opacity with significant cataract is often a triple procedure. However, in certain situations the chances of graft survival are poor, for example in cases with deep vascularization, secondary glaucoma, and healed viral keratitis. Under these circumstances, performing cataract surgery only might improve the visual acuity enough to maintain the patient's day-to-day activities. Read More

Eur J Public Health 2018 Nov 29. Epub 2018 Nov 29.

Agència de Salut Pública de Barcelona, Barcelona, Spain.

Background: In high-income countries, the prevalence of blindness and visual impairment is higher among women, regardless of age although the mechanisms that produce these gender inequalities are not well understood. The objectives of this study were to analyse gender inequalities in the prevalence of blindness and visual impairment, age of onset, diagnosed and undiagnosed status and related eye diseases among visually impaired individuals.

Methods: Data were obtained from the 2008 Spanish Survey on 'Disability, Personal Autonomy and Dependency Situations' (n = 213 626) participants 360 blind (160 men and 200 women), and 5560 with some visual impairment (2025 men and 3535 women). Read More

Exp Eye Res 2018 Nov 27;180:8-17. Epub 2018 Nov 27.

Department of Biological Sciences, Chungnam National University, Daejeon, South Korea. Electronic address:

Receptor interacting protein kinase 1 (RIPK1) plays a key role in necroptosis, which is a type of programmed necrosis that is involved in ocular diseases, including glaucoma and dry age-related macular degeneration (AMD). We previously introduced RIPK1-inhibitory compound (RIC), which has biochemical characteristics and a mode of action that are distinct from those of the prototype RIPK1 inhibitor necrostatin-1. The intraperitoneal administration of RIC exerts a protective effect on retinal ganglion cells against a glaucomatous insult. Read More

Cornea 2018 Nov 28. Epub 2018 Nov 28.

Department of Ophthalmology, Tokyo Dental College, Ichikawa General Hospital, Chiba, Japan.

Purpose: To evaluate the effect of iris damage on endothelial cell loss in the early phase after penetrating keratoplasty (PKP).

Methods: This prospective consecutive study included 74 patients who underwent PKP without graft rejection during the follow-up period. Endothelial cell density (ECD) was measured using specular microscopy at 1, 3, 6, and 12 months after PKP. Read More

Vestn Oftalmol 2018 ;134(5):111-117

Research Institute of Eye Diseases, 11A Rossolimo St., Moscow, Russian Federation, 119021.

The article reviews the history of glaucoma surgery and analyses the connection between the accumulation of knowledge on glaucoma progression and the emergence of effective surgical treatment methods based on glaucoma pathogenesis. It also describes modern principles of preventing filtering bleb scarring. Particular attention is devoted to biodegradable collagen matrix implants. Read More