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J Curr Glaucoma Pract 2019 Sep-Dec;13(3):104-109

Department of Ophthalmology, UCI Health Gavin Herbert Eye Institute, University of California, Irvine, California, USA.

Aim: Our goal is to review current literature regarding drug-induced acute angle-closure glaucoma (AACG) and provide ophthalmologists and general practitioners with a thorough understanding of inciting medications and treatment pitfalls to be avoided.

Background: Drug-induced AACG is an ophthalmological emergency that ophthalmologists and general practitioners should be familiar with, given its potentially blinding consequences. Common anatomical risk factors for AACG include a shallow anterior chamber depth, short axial length, plateau iris configuration, thick lens, anteriorly positioned lens, and rarely, intraocular tumor. Read More

Arch Soc Esp Oftalmol 2020 May 15. Epub 2020 May 15.

Departamento de Oftalmología, Hospital Puerta de Hierro Majadahonda, Madrid, España; Departamento de Oftalmología, Universidad de Castilla La Mancha, Albacete, España.

Case Report: A 31-year-old male was referred for evaluation after being diagnosed with Cushing syndrome secondary to a pituitary microadenoma. He presented with a reduced visual acuity and high intraocular pressure (IOP) of 48mmHg in both eyes. The examination with biomicroscopy showed normal anterior segment, increased cup to disc ratio, and open angle. Read More

BMC Ophthalmol 2020 Apr 28;20(1):168. Epub 2020 Apr 28.

Department of ophthalmology, the first hospital affiliated to Army Medical University (Southwest Hospital), Chongqing, 400038, China.

Background: To report a case of a young patient with neurofibromatosis type 1 (NF1).

Methods: Here we review the treatment administered to a 7-year-old NF1 patient with neovascular glaucoma as the primary diagnosis.

Case Presentation: A 7-year-old boy developed visual loss in the right eye associated with periocular pain and ipsilateral headache that had persisted for 1 week. Read More

Int Ophthalmol 2020 Jul 20;40(7):1789-1795. Epub 2020 Mar 20.

Ophthalmic Plastic Surgery and Ocular Oncology Services, The Operation Eyesight Universal Institute for Eye Cancer, LV Prasad Eye Institute, Hyderabad, 500034, India.

Purpose: To discuss the clinical presentation and management of intraocular tumors masquerading as primary glaucoma or non-tumor-related secondary glaucoma.

Methods: Retrospective chart review.

Results: Ten patients with unsuspected intraocular tumor were referred to glaucoma clinic with a diagnosis of primary glaucoma or non-tumor-related secondary glaucoma. Read More

Case Rep Ophthalmol 2020 Jan-Apr;11(1):68-72. Epub 2020 Feb 4.

Private Retina Office, University of Buenos Aires, Buenos Aires, Argentina.

Background: Iris microhemangiomatosis is a rare vascular iris tumor, with potential severe complications such as increased intraocular pressure (IOP). We aim to describe a case report of a patient presenting with hyphema secondary to iris microhemangiomatosis triggered by excessive high blood pressure.

Case Presentation: A 74-year-old woman was treated for hypertensive crisis. Read More

Ophthalmology 2020 02 24;127(2):240-248. Epub 2019 Sep 24.

Department of Ophthalmology, Emory University School of Medicine, Atlanta, Georgia.

Purpose: Cutaneous melanoma metastatic to the vitreous is very rare. This study investigated the clinical findings, treatment, and outcome of patients with metastatic cutaneous melanoma to the vitreous. Most patients received checkpoint inhibition for the treatment of systemic disease, and the significance of this was explored. Read More

BMJ Case Rep 2019 Oct 25;12(10). Epub 2019 Oct 25.

Ophthalmology Department, University Hospital of Wales, Cardiff, UK.

Retinoblastoma is the most common intraocular malignancy of infancy which frequently manifests with a white pupillary reflex. We report a case of delayed presentation of a child with retinoblastoma in his left eye because parents thought the change in iris colour in this eye was due to the innocent heterochromia irides that was previously diagnosed in his elder sibling. This late presentation necessitated enucleation of the affected eye followed by chemotherapy. Read More

Medicine (Baltimore) 2019 Oct;98(40):e17441

Department of Ophthalmology, Zhejiang Medicine and Western Medicine Integrated Hospital (Hangzhou Red-Cross Hospital), Hangzhou, Zhejiang, P.R. China.

Rationale: Although metastatic tumor is the most common intraocular malignancy, choroidal metastasis from gastric cancer is relatively rare. We present the exact course of a spontaneous rupture of the eyeball with choroidal metastasis from gastric carcinoma (GC) and the applied surgical interventions.

Patient Concerns: A 59-year-old male presented with pain and vision loss on his left eye for 6 months. Read More

Pediatr Blood Cancer 2019 12 6;66(12):e27977. Epub 2019 Sep 6.

Department of Pediatrics, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Japan.

Background: Corticosteroids, especially dexamethasone, play a critical role in chemotherapy for pediatric hematological malignancies. We previously observed that patients with complaints of headache or photophobia during corticosteroid administration had high intraocular pressure (IOP).

Procedure: We measured IOP during corticosteroid administration in 15 patients with acute leukemia or lymphoma undergoing treatment at our institution from January 2016 to December 2018. Read More

Acta Ophthalmol 2020 Feb 17;98(1):e121-e125. Epub 2019 Aug 17.

The Vision Center at Children's Hospital Los Angeles, Los Angeles, California, USA.

Purpose: To determine the significance of large tumour size as a criteria for classifying advanced intraocular retinoblastoma, analysing rates of globe survival and high-risk (HE) histopathologic features.

Methods: Retrospective chart review of 212 eyes diagnosed with Group D (111 eyes) or Group E (101 eyes) retinoblastoma in at least one eye from January 1, 2006 to December 31, 2016 using the Los Angeles (LA) Classification System (no tumour size criteria for Group E). The 111 Group D tumours were then reclassified to Group E using 10, 12, 14, 16, 18 mm tumour size criteria, as determined by ultrasound or magnetic resonance imaging dimensions. Read More

Eye (Lond) 2020 Feb 10;34(2):319-326. Epub 2019 Jul 10.

Ophthalmic Pathology Services (DKM), L V Prasad Eye Institute, Hyderabad, India.

Purpose: To describe the clinical features, histopathology and treatment of ocular surface squamous neoplasia (OSSN) with intraocular tumour extension.

Methods: Retrospective study of 23 patients.

Results: The mean age at presentation of OSSN with intraocular tumour extension was 48 years. Read More

Oman J Ophthalmol 2019 May-Aug;12(2):125-128

The Operation Eyesight Universal Institute for Eye Cancer, Hyderabad, Telangana, India.

Schwannoma is a rare benign tumor, which is more commonly found elsewhere in the body along myelin-producing peripheral nerves and is rarely reported within the eye. In this report, we describe two adult patients presenting with a choroidal mass lesion and neovascular glaucoma who underwent enucleation with clinical differential diagnoses of choroidal melanoma and choroidal hemangioma. Histopathology confirmed the diagnosis of choroidal schwannoma. Read More

Indian J Ophthalmol 2019 06;67(6):755-762

Department of Ocular Oncology, Centre for Sight, Hyderabad, Telangana, India.

Intraocular medulloepithelioma is a nonhereditary neoplasm of childhood arising from primitive medullary epithelium. It most often involves the ciliary body. Most patients present between 2 and 10 years of age with loss of vision, pain, leucocoria, or conjunctival congestion. Read More

Ophthalmic Surg Lasers Imaging Retina 2019 05;50(5):e163-e165

The authors describe the clinical and anatomical correlation between mean ocular perfusion pressure (MOPP) changes and macular exudation in a 62-year-old man affected by circumscribed choroidal hemangioma (CCH) and primary open-angle glaucoma. During the 5-year follow-up, we noted an increase of the subretinal fluid (SRF) and cystoid macular edema (CME) when the intraocular pressure (IOP) was in the low teens. Optical coherence tomography scans performed during an isometric exercise revealed a transient increase of the retinal (choroidal) thickness. Read More

Ophthalmic Surg Lasers Imaging Retina 2019 05;50(5):314-317

Intraocular medulloepithelioma is a rare congenital tumor that arises from the nonpigmented epithelium of the ciliary body. It is the second most common primary intraocular neoplasm during the first decade of life. It may present with an iris mass or cyst (56%), glaucoma (48%), cataract (26%), leukocoria (18%), decrease in vision (41%), or pain (30%). Read More

J Glaucoma 2019 07;28(7):e124-e125

Division of Ophthalmology, Faculty of Medicine and Health Sciences, Tygerberg Academic Hospital and Stellenbosch University, Cape Town, South Africa.

Background: Phacomatosis pigmentovascularis (PPV) has previously almost exclusively been reported in Asians and in dermatological journals. In this report, we present a case of a young black South African adolescent boy referred to our eye clinic.

Case Report: A 15-year-old male patient presented with gradual, painless loss of vision in his right eye. Read More

J Ophthalmol 2019 14;2019:2042459. Epub 2019 Feb 14.

Department of Ophthalmology, Semmelweis University, Budapest, Hungary.

Purpose: To analyse current clinicopathological enucleation indications in a large third-referral centre in a developed country (Hungary) over a period of 12 years.

Methods: Retrospective review was performed on 547 enucleated eyes of 543 patients (48.6% males, age 52. Read More

J Glaucoma 2019 06;28(6):e103-e106

University Hospital Nord, Chemin des Bourrely, Marseille, France.

Purpose: The main purpose of this study was to describe a unique case of retro-orbital infantile hemangioma (IH) simulating a congenital glaucoma requiring prompt management with systemic propranolol.

Study Design: This was a case report.

Results: A 2-month-old white female was referred to our department of ophthalmology for progressive, unilateral protrusion of the left eye associated with epiphora. Read More

Pediatr Int 2019 Feb 7;61(2):208-210. Epub 2019 Feb 7.

Department of Pediatric Hematology and Oncology, Okayama University Hospital, Okayama, Japan.

Br J Ophthalmol 2019 12 22;103(12):1856-1861. Epub 2019 Feb 22.

Ocular Oncology Service, Centre for Sight, Hyderabad, India.

Background/aim: To report the outcomes of retinoblastoma group E eyes with neovascular glaucoma (NVG) treated conservatively with intravenous chemotherapy and investigate factors associated with eye salvage and secondary enucleation.

Methods: This is a retrospective, comparative, interventional case series. The outcome measures were life salvage, eye salvage and vision salvage. Read More

Indian J Ophthalmol 2019 Mar;67(3):350-357

Department of Ocular Tumor, Orbital Disease and Ophthalmic Radiation Therapy, The New York Eye Cancer Center, New York City, New York, USA.

Purpose: The purpose of this study is to describe the clinical characteristics, multimodality imaging findings, and clinical course of iris varices.

Methods: Retrospective, noncomparative, observational case series of 28 eyes of 26 patients with iris varices, diagnosed between 2007 and 2017, has been used.

Results: The mean (±SD) age was 58. Read More

Indian J Ophthalmol 2019 Feb;67(2):285-287

Glaucoma Research and Clinical Facility, Department of Ophthalmology, Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India.

A 45-year-old diabetic male, with diabetic retinopathy and medically uncontrolled neovascular glaucoma (NVG) underwent intracameral bevacizumab followed by trabeculectomy, with controlled intraocular pressures (IOP) post-operatively, OD: 12 mmHg; OS: 14 mmHg. Patient was referred to hematology, where he was diagnosed as chronic myeloid leukemia (CML) and started on imatinib mesylate. Thereafter, he presented with recurrence of neovascularization and vascularization of the bleb along with OS vitreous hemorrhage at 6 weeks follow-up. Read More

BMJ Case Rep 2019 Jan 10;12(1). Epub 2019 Jan 10.

Ophthalmology, Norfolk and Norwich University Hospitals NHS Foundation Trust, Norwich, UK.

This case report describes a 35-year-old Caucasian man who was referred to the glaucoma clinic with high intraocular pressure (IOP) after routine optometrist assessment. He was diagnosed with ocular hypertension (OHT) and the management plan was for monitoring without treatment. Three months later, he presented to the endocrine clinic with symptoms of Cushing's disease and was diagnosed with an adrenocorticotropic hormone secreting pituitary microadenoma. Read More

Optom Vis Sci 2019 01;96(1):71-75

San Francisco Veterans Affairs Health Care System, San Francisco, California.

Significance: Patients with pigment dispersion syndrome are frequently encountered in clinical practice. Iris abnormalities and the absence of key features of pigment dispersion syndrome can guide the discovery of secondary causes of pigmentary glaucoma, such as peripheral iris pigment epithelial cysts.

Purpose: The purpose of this study was to describe a patient initially diagnosed as having primary pigmentary glaucoma found to have multiple bilateral peripheral iris pigment epithelial cysts causing pigment liberation, focal angle closure, and advanced secondary glaucoma. Read More

Eur J Ophthalmol 2020 Jan 19;30(1):168-174. Epub 2018 Dec 19.

Ophthalmology Department, Faculty of Medicine, Alexandria University, Alexandria, Egypt.

Purpose: To report on the clinical presentation and surgical treatment (procedure and outcome(s)) of glaucoma in children with facial port wine stain.

Materials And Methods: This is a retrospective chart review of children with facial port wine stain referred to Alexandria University paediatric ophthalmology practice from 2005 to 2016. The charts of 22 children (44 eyes) with facial port wine stain were reviewed. Read More

Curr Opin Ophthalmol 2019 Mar;30(2):71-81

Ocular Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, Pennsylvania.

Purpose Of Review: Glaucoma secondary to intraocular tumors is important to consider in eyes with a known tumor and those with unilateral or refractory glaucoma. The purpose of this review is to discuss the mechanisms and management of intraocular tumors with related secondary glaucoma.

Recent Findings: Several intraocular tumors can lead to glaucoma, including iris melanoma, iris metastasis, iris lymphoma, trabecular meshwork melanoma, choroidal melanoma, choroidal metastasis, retinoblastoma, and medulloepithelioma. Read More

JAMA Ophthalmol 2019 01;137(1):91-95

Vascular Biology Program, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts.

Importance: Choroidal hemangiomas are defined by a thickened choroid owing to vessel overgrowth, which may increase the intraocular pressure and lead to glaucoma. Choroidal hemangioma and glaucoma often co-occur in patients with Sturge-Weber syndrome, a rare neurocutaneous disorder characterized by capillary malformations.

Objective: To determine whether the mutation found in most capillary malformations, GNAQ R183Q (c. Read More

BMJ Case Rep 2018 Oct 24;2018. Epub 2018 Oct 24.

Department of Ophthalmology and Visual Sciences, College of Medicine, University of the Philippines Manila, Manila, Philippines.

To report a case of retinoblastoma presenting as haemorrhagic choroidal detachment in a 10-year-old girl. The patient, apparently well, presented with sudden blurring of vision in the setting of blunt trauma. On examination and ocular ultrasound, haemorrhagic choroidal detachment was suspected. Read More

Eye (Lond) 2019 03 18;33(3):464-468. Epub 2018 Oct 18.

Department of Ophthalmology, Army Hospital (Research and Referral), Delhi Cantt, New Delhi, 110010, India.

Purpose: To evaluate the efficacy and safety of Ahmed valve implantation in childhood glaucoma associated with Sturge-Weber syndrome (SWS).

Methods: A retrospective chart review of patients who underwent primary Ahmed valve implantation in childhood glaucoma associated with SWS. The outcome measures were success rate (Intraocular pressure (IOP) >5 and <21 mm Hg without additional surgical maneuver), and operative complications. Read More

Neoplasma 2018 Nov 4;65(6):965-971. Epub 2018 Sep 4.

Department of Ophthalmology, Faculty of Medicine, Comenius University, Bratislava, Slovakia.

This paper presents the long-term results of single dose stereotactic radiosurgery for intraocular uveal malignant melanoma, and summarizes the results of the retrospective study in 170 Slovak patients. A group of uveal melanoma patients (149 choroidal melanoma, 21 ciliary body melanoma) from 20 to 92 years of age with 59 year median were treated in 2001-2016. There were 81males (47. Read More

Eur J Ophthalmol 2020 Jan 7;30(1):NP5-NP6. Epub 2018 Oct 7.

Clínica Oftalmológica Rahhal, Valencia, Spain.

We present an unusual case of Sturge-Weber syndrome whose main clinical manifestations were nevus flammeus, seizures, glaucoma, and acoria. To our knowledge, the combination of Sturge-Weber syndrome and acoria has not been previously reported. Read More

Arch Soc Esp Oftalmol 2018 Dec 27;93(12):610-612. Epub 2018 Sep 27.

Sección de Glaucoma, FISABIO Oftalmología Médica, Valencia, España.

Case Report: The case is presented of a patient referred to us with suspicion of a ciliary body melanoma due to a pigmented lesion in iris root of left eye, associated with high intraocular pressure, despite maximal topical and systemic medication. The systematic workup revealed unilateral changes in the corneal endothelium, compatible with an iridocorneal syndrome. An Ahmed valve was inserted, achieving sustained control of intraocular pressure and visual field defects. Read More

JAMA Ophthalmol 2018 09 13;136(9):e182381. Epub 2018 Sep 13.

State Key Laboratory of Ophthalmology, Department of Glaucoma, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China.

Cornea 2018 Nov;37(11):1468-1470

Department of Ophthalmology, Ocular Tumor Service, New York Eye and Ear Infirmary of Mount Sinai, New York, NY.

Purpose: To present a unique approach to eye and vision sparing for a patient with squamous cell carcinoma invading through a penetrating keratoplasty (PK) wound.

Methods: A 56-year-old functionally monocular man was found to have squamous cell carcinoma with intraocular invasion through a PK wound. Eye- and vision-salvaging palladium-103 plaque radiation was performed. Read More

Am J Ophthalmol Case Rep 2018 Sep 24;11:49-51. Epub 2018 May 24.

Weill-Cornell Medical Center, New York, NY, 10065, USA.

Purpose: To report on two cases of treatment-refractory juxtapapillary hemagioblastomas that were managed with intra-arterial bevacizumab delivered via the ophthalmic artery.

Observations: Case 1 is a 35 year-old man with juxtapapillary hemangioblastoma who continued to have progressive tractional retinal detachment, optic nerve neovascaularization and cystoid macula edema (CME) despite heavy prior treatment with intravitreal anti-vascular endothelial growth factor (VEGF) and steroid intravitreal injections and laser. Case 2 is a 41 year-old woman with juxtapapillary hemangioblastoma who had progressive tractional retinal detachment, CME and visually-threatening intraocular pressure elevation despite treatment with anti-VEGF injection and laser. Read More

J Glaucoma 2018 07;27(7):578-584

Singapore National Eye Centre.

Objective: The objective of this article was to study longitudinal changes in bleb morphology (presence of microcysts and bleb height and vascularity) in subjects enrolled in the Singapore 5-Fluorouracil (5-FU) trabeculectomy study.

Study Design: Retrospective subgroup analysis of a randomized controlled trial.

Materials And Methods: Following trabeculectomy with either 5-FU or placebo, subjects were reviewed at day 1, weeks 1, 2, and 3, and months 3, 6, 9, 12, 16, 20, 24, 28, 32, and 36 and intraocular pressure (IOP), presence of microcysts and bleb height and vascularity graded and recorded. Read More

Int Ophthalmol 2019 Jun 8;39(6):1405-1412. Epub 2018 Jun 8.

Ophthalmic Research Center, Shahid Beheshti University of Medical Sciences, No. 23, Paidarfard St., Pasdaran Ave., Tehran, 16666, Iran.

Purpose: Presentation of two typical cases with characteristic leopard retinopathy secondary to bilateral diffuse uveal melanocytic proliferation (BDUMP) and idiopathic uveal effusion syndrome (IUES) and brief review of the literature about leopard spot retinopathy.

Case Report: A 43-year-old women, who was a known case of ovarian carcinoma, referred with gradual bilateral visual loss. In ophthalmic examination, subretinal fluid, multiple patchy subretinal hyperpigmented lesions and leopard spot chorioretinopathy were evident in her both eyes. Read More

Arq Bras Oftalmol 2018 Jun;81(3):254-261

Ophthalmology Department, Hospital Nossa Senhora da Conceição, Porto Alegre, RS, Brazil.

The diagnosis of angle-closure glaucoma secondary to iridociliary cysts is challenging and lacks compiled literature support. We present a rare case of bilateral angle-closure glaucoma associated with pseudoplateau iris due to multiple ciliary cysts and conducted a systematic review of the literature to find similar case reports published between November 2006 and November 2016. Only 19 case reports present treatment modalities, and most cases required more than one therapeutic approach for controlling the intraocular pressure. Read More

J Glaucoma 2018 09;27(9):e145-e147

Department of Ophthalmology, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Great Neck.

Purpose: We describe a case of bilateral angle closure glaucoma following the infusion of daratumumab, a monoclonal antibody used to treat relapsing multiple myeloma.

Methods: This is an interventional case report.

Results: A 59-year-old woman presented with bilateral angle closure glaucoma one day following her first infusion of daratumumab. Read More

BMC Ophthalmol 2018 May 25;18(1):125. Epub 2018 May 25.

Department of Ophthalmology, Nara Medical University School of Medicine, 840 Shijo-cho, Kashihara, Nara, 634-8522, Japan.

Background: A case of iris metastasis preceding the diagnosis of gastric signet ring cell adenocarcinoma is very rare. To report the findings in a patient who presented with an iris tumor that was later identified to have metastasized from a gastric signet ring cell adenocarcinoma.

Case Presentation: A-74-year-old woman presented with visual disturbance and an increased intraocular pressure (IOP) in the right eye. Read More

BMJ Case Rep 2018 May 16;2018. Epub 2018 May 16.

Department of Ophthalmology, Bogomolets National Medical University, Kyiv, Ukraine.

A 30-year-old European man was admitted to our centre complaining about severe pain of the right eye (OD) and right part of the face, redness and no vision of the OD. He had an 18-year history of secondary to Sturge-Weber syndrome glaucoma, 6-month history of red eye and 1-week history of pain in OD. The best-corrected visual acuity was no light perception OD and 20/20 OS. Read More

J Glaucoma 2018 06;27(6):e113-e116

Department of Ophthalmology, Edward S. Harkness Eye Institute, Columbia University College of Physicians and Surgeons, New York, NY.

Purpose: The purpose of this article was to report the efficacy of intravitreal bevacizumab to resolve secondary angle-closure glaucoma caused by biliary tract carcinoma metastasis to the iris.

Materials And Methods: A 52-year-old white woman who was under systemic chemotherapy for biliary tract carcinoma presented with a metastatic tumor in the left iris. At presentation, her visual acuity was at the 20/50 level. Read More

J Neurosci Res 2019 01 1;97(1):57-69. Epub 2018 Apr 1.

Illinois Eye and Ear Infirmary, Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, Illinois.

The phakomatoses, encephalotrigeminal angiomatosis (ETA; Sturge-Weber Syndrome), neurofibromatosis type 1 (NF1 or von Recklinghausen disease), Von Hippel-Lindau (VHL) disease, tuberous sclerosis (TSC), oculodermal melanocytosis (ODM), and phakomatosis pigmentovascularis are a group of neurocutaneous disorders that have characteristic systemic and ocular manifestations. Through many different mechanisms, they may cause glaucomatous damage of the optic nerve and subsequent vision loss varying from mild to severe. Glaucoma commonly affects patients with ETA (43-72%), orbito-facial NF1 (23-50%), and ODM (10%). Read More

BMC Ophthalmol 2018 Feb 23;18(1):54. Epub 2018 Feb 23.

Department of Ophthalmology, Zhejiang Chinese Medical Hospital, Hangzhou, 31006, China.

Background: The management of eyes with nanophthalmos is a dilemma for ophthalmologists due to various complications, especial the eye with malignant glaucoma. We report a case of effective treatment for malignant glaucoma in nanophthalmos.

Case Presentation: An 82-year-old man was performed phacoemulsification in the right eye with normal ocular pressure and nanophthalmos. Read More

Int Ophthalmol 2019 Mar 8;39(3):683-685. Epub 2018 Feb 8.

Conquest Hospital Eye Clinic, Conquest Hospital, The Ridge, St Leonards-on-Sea, TN37 7RD, UK.

Introduction: Topical beta-blockers are a proven and safe medication used in the treatment of glaucoma and ocular hypertension. Local and systemic side effects are, however, well documented. Systemic side effects can include severe cardio-respiratory impairment, endocrine dysfunction, as well as headache and hyper-somnolence. Read More

J Glaucoma 2018 04;27(4):385-388

Department of Ophthalmology, University Hospitals Coventry and Warwickshire NHS Trust, Coventry.

Purpose: We report a previously unrecognized mechanism of secondary glaucoma due to iridescent crystalline particles released from an irradiated iris melanoma. It masqueraded as refractory hypertensive uveitis following uncomplicated phacoemulsification.

Materials And Methods: A 58-year-old gentleman had an iris melanoma that underwent successful regression following irradiation with proton beam radiotherapy. Read More

Int Ophthalmol 2019 Mar 1;39(3):677-682. Epub 2018 Feb 1.

Department of Ophthalmology, Kyorin University School of Medicine, 6-20-2 Shinkawa, Mitaka, Tokyo, 181-8611, Japan.

Purpose: To determine the optical coherence tomography angiography (OCTA) characteristics of a case of optic disc melanocytoma (ODM) associated with glaucomatous visual field and retinal nerve fiber layer (RNFL) defects in normal tension glaucoma.

Methods: The left eye of a 37-year-old female patient followed for a stable ODM for 10 years was investigated with OCT, OCTA, fluorescein (FA), and indocyanine green (ICGA) angiography. The ODM was unchanged, but a previously unknown inferotemporal neuroretinal rim loss and inferotemporal and superotemporal wedge shape glaucomatous RNFL thinning were seen with corresponding glaucomatous visual field defects. Read More

Indian J Ophthalmol 2018 Feb;66(2):317-319

Department of Ophthalmology, Laboratory Technician, Sri Sankaradeva Nethralaya, Guwahati, Assam, India.

We describe a case of spontaneous hyphema associated with anterior uveitis presents in a 69-year old female as the prominent sign of the intraocular spread of systemic diffuse large B-cell lymphoma (DLBCL). She had a history of diabetes and initially misdiagnosed as neovascular glaucoma. Clinical history of systemic lymphoma, characteristic findings on B-scan ultrasonography and magnetic resonance imaging scan, and identification of atypical lymphoid cells in aqueous sample established the diagnosis of intraocular metastasis of systemic DLBCL. Read More

Asia Pac J Ophthalmol (Phila) 2018 Mar-Apr;7(2):95-98. Epub 2017 Dec 27.

Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL.

Purpose: The incidence of infantile-onset secondary glaucoma associated with periocular cutaneous vascular malformations is high and the outcomes of these glaucomatous eyes have anecdotally been poor. The purpose of this study was to determine the anatomic and visual outcomes of affected eyes.

Design: Retrospective case series. Read More

Chin Med J (Engl) 2017 Dec;130(24):2922-2926

Department of Ophthalmology, Ninth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China.

Background: The location of facial port-wine stain (PWS) may be helpful for predicting some associated anomalies; high glaucoma incidence is found in patients with eyes close to PWS-affected areas (V1, ophthalmic branch area of the trigeminal nerve). This study aimed to investigate the characteristics of glaucoma in V1-affected PWS.

Methods: A total of 569 patients with V1 area-affected PWS were reviewed in the study. Read More