Search Our Scientific Publications & Authors

Curr Opin Ophthalmol 2019 Mar;30(2):71-81

Ocular Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, Pennsylvania.

Purpose Of Review: Glaucoma secondary to intraocular tumors is important to consider in eyes with a known tumor and those with unilateral or refractory glaucoma. The purpose of this review is to discuss the mechanisms and management of intraocular tumors with related secondary glaucoma.

Recent Findings: Several intraocular tumors can lead to glaucoma, including iris melanoma, iris metastasis, iris lymphoma, trabecular meshwork melanoma, choroidal melanoma, choroidal metastasis, retinoblastoma, and medulloepithelioma. Read More

BMJ Case Rep 2018 Oct 24;2018. Epub 2018 Oct 24.

Department of Ophthalmology and Visual Sciences, College of Medicine, University of the Philippines Manila, Manila, Philippines.

To report a case of retinoblastoma presenting as haemorrhagic choroidal detachment in a 10-year-old girl. The patient, apparently well, presented with sudden blurring of vision in the setting of blunt trauma. On examination and ocular ultrasound, haemorrhagic choroidal detachment was suspected. Read More

Cornea 2018 Nov;37(11):1468-1470

Department of Ophthalmology, Ocular Tumor Service, New York Eye and Ear Infirmary of Mount Sinai, New York, NY.

Purpose: To present a unique approach to eye and vision sparing for a patient with squamous cell carcinoma invading through a penetrating keratoplasty (PK) wound.

Methods: A 56-year-old functionally monocular man was found to have squamous cell carcinoma with intraocular invasion through a PK wound. Eye- and vision-salvaging palladium-103 plaque radiation was performed. Read More

Am J Ophthalmol Case Rep 2018 Sep 24;11:49-51. Epub 2018 May 24.

Weill-Cornell Medical Center, New York, NY, 10065, USA.

Purpose: To report on two cases of treatment-refractory juxtapapillary hemagioblastomas that were managed with intra-arterial bevacizumab delivered via the ophthalmic artery.

Observations: Case 1 is a 35 year-old man with juxtapapillary hemangioblastoma who continued to have progressive tractional retinal detachment, optic nerve neovascaularization and cystoid macula edema (CME) despite heavy prior treatment with intravitreal anti-vascular endothelial growth factor (VEGF) and steroid intravitreal injections and laser. Case 2 is a 41 year-old woman with juxtapapillary hemangioblastoma who had progressive tractional retinal detachment, CME and visually-threatening intraocular pressure elevation despite treatment with anti-VEGF injection and laser. Read More

Arq Bras Oftalmol 2018 Jun;81(3):254-261

Ophthalmology Department, Hospital Nossa Senhora da Conceição, Porto Alegre, RS, Brazil.

The diagnosis of angle-closure glaucoma secondary to iridociliary cysts is challenging and lacks compiled literature support. We present a rare case of bilateral angle-closure glaucoma associated with pseudoplateau iris due to multiple ciliary cysts and conducted a systematic review of the literature to find similar case reports published between November 2006 and November 2016. Only 19 case reports present treatment modalities, and most cases required more than one therapeutic approach for controlling the intraocular pressure. Read More

BMC Ophthalmol 2018 May 25;18(1):125. Epub 2018 May 25.

Department of Ophthalmology, Nara Medical University School of Medicine, 840 Shijo-cho, Kashihara, Nara, 634-8522, Japan.

Background: A case of iris metastasis preceding the diagnosis of gastric signet ring cell adenocarcinoma is very rare. To report the findings in a patient who presented with an iris tumor that was later identified to have metastasized from a gastric signet ring cell adenocarcinoma.

Case Presentation: A-74-year-old woman presented with visual disturbance and an increased intraocular pressure (IOP) in the right eye. Read More

BMJ Case Rep 2018 May 16;2018. Epub 2018 May 16.

Department of Ophthalmology, Bogomolets National Medical University, Kyiv, Ukraine.

A 30-year-old European man was admitted to our centre complaining about severe pain of the right eye (OD) and right part of the face, redness and no vision of the OD. He had an 18-year history of secondary to Sturge-Weber syndrome glaucoma, 6-month history of red eye and 1-week history of pain in OD. The best-corrected visual acuity was no light perception OD and 20/20 OS. Read More

J Glaucoma 2018 Jun;27(6):e113-e116

Department of Ophthalmology, Edward S. Harkness Eye Institute, Columbia University College of Physicians and Surgeons, New York, NY.

Purpose: The purpose of this article was to report the efficacy of intravitreal bevacizumab to resolve secondary angle-closure glaucoma caused by biliary tract carcinoma metastasis to the iris.

Materials And Methods: A 52-year-old white woman who was under systemic chemotherapy for biliary tract carcinoma presented with a metastatic tumor in the left iris. At presentation, her visual acuity was at the 20/50 level. Read More

BMC Ophthalmol 2018 Feb 23;18(1):54. Epub 2018 Feb 23.

Department of Ophthalmology, Zhejiang Chinese Medical Hospital, Hangzhou, 31006, China.

Background: The management of eyes with nanophthalmos is a dilemma for ophthalmologists due to various complications, especial the eye with malignant glaucoma. We report a case of effective treatment for malignant glaucoma in nanophthalmos.

Case Presentation: An 82-year-old man was performed phacoemulsification in the right eye with normal ocular pressure and nanophthalmos. Read More

Indian J Ophthalmol 2018 Feb;66(2):317-319

Department of Ophthalmology, Laboratory Technician, Sri Sankaradeva Nethralaya, Guwahati, Assam, India.

We describe a case of spontaneous hyphema associated with anterior uveitis presents in a 69-year old female as the prominent sign of the intraocular spread of systemic diffuse large B-cell lymphoma (DLBCL). She had a history of diabetes and initially misdiagnosed as neovascular glaucoma. Clinical history of systemic lymphoma, characteristic findings on B-scan ultrasonography and magnetic resonance imaging scan, and identification of atypical lymphoid cells in aqueous sample established the diagnosis of intraocular metastasis of systemic DLBCL. Read More

Asia Pac J Ophthalmol (Phila) 2018 Mar-Apr;7(2):95-98. Epub 2017 Dec 27.

Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL.

Purpose: The incidence of infantile-onset secondary glaucoma associated with periocular cutaneous vascular malformations is high and the outcomes of these glaucomatous eyes have anecdotally been poor. The purpose of this study was to determine the anatomic and visual outcomes of affected eyes.

Design: Retrospective case series. Read More

Chin Med J (Engl) 2017 Dec;130(24):2922-2926

Department of Ophthalmology, Ninth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China.

Background: The location of facial port-wine stain (PWS) may be helpful for predicting some associated anomalies; high glaucoma incidence is found in patients with eyes close to PWS-affected areas (V1, ophthalmic branch area of the trigeminal nerve). This study aimed to investigate the characteristics of glaucoma in V1-affected PWS.

Methods: A total of 569 patients with V1 area-affected PWS were reviewed in the study. Read More

Pan Afr Med J 2017 22;28:66. Epub 2017 Sep 22.

Department of Paediatrics and Adolescent Health, Faculty of Medicine, University of Botswana, Gaborone, Botswana.

Introduction: Retinoblastoma is a primary malignant intraocular neoplasm that arise from immature retinoblasts with in developing retina. The commonest presenting sign in developing country is proptosis which is the late presenting sign. We report presenting signs of retinoblastoma in Ethiopian children seen at a tertiary level teaching hospitals in Ethiopia. Read More

Am J Ophthalmol 2018 02 6;186:173-174. Epub 2017 Dec 6.

Baltimore, Maryland.

J Glaucoma 2017 Dec;26(12):1068-1071

Department of Anesthesiology and Pain Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.

Purpose: To investigate the effects of continuous systemic administration of esmolol on intraocular pressure (IOP) during laparoscopic and robotic surgeries for recto-sigmoid cancer in a steep Trendelenburg position.

Materials And Methods: A total of 50 patients undergoing laparoscopic surgery in a steep Trendelenburg position were included. Patients in the esmolol (E) group received a 0. Read More

Clin Case Rep 2017 11 25;5(11):1811-1818. Epub 2017 Sep 25.

Department of Companion Animal Clinical Sciences Faculty of Veterinary Medicine and Biosciences Norwegian University of Life Sciences Oslo Norway.

A uveal leiomyosarcoma of a horse is reported. There are few published reports of intraocular tumors in horses. Intraocular tumors challenge animal welfare by causing uveitis, glaucoma, and loss of vision. Read More

Graefes Arch Clin Exp Ophthalmol 2018 Feb 7;256(2):411-420. Epub 2017 Nov 7.

Ophthalmology Department, Institut Curie, Paris, France.

Background: To evaluate the efficacy of bevacizumab on reduction of the enucleation rate and control of intraocular pressure (IOP) in neovascular glaucoma (NVG)-complicating proton beam therapy for UM and to identify the determinants of the efficacy of bevacizumab.

Methods: Retrospective comparative study of patients with rubeosis following proton therapy for uveal melanoma. Patients were divided into two groups: a bevacizumab group and a control group which comprised two subgroups: panretinal photocoagulation (PRP)/cryotherapy and observation subgroups. Read More

Eur Rev Med Pharmacol Sci 2017 Sep;21(18):3985-3989

Institute of Xuzhou Eye Prevention and Control, Department of Ophthalmology, the First People's Hospital of Xuzhou City, Jiangsu Province, China.

Objective: The objective of this study was to examine the correlation between the presence of primary iris-ciliary cysts and the intraocular pressure.

Patients And Methods: Sixty patients with short-sightedness undergoing routine examination for laser vision correction in our hospital in 2003 were enrolled. Patients with known high intraocular pressure and risk of glaucoma were excluded from the study. Read More

BMJ Case Rep 2017 Oct 4;2017. Epub 2017 Oct 4.

Department of Ophthalmology, Ohio State University, Columbus, Ohio, USA.

A 39-year-old Caucasian man with bilateral narrow angles, a plateau-like iris configuration on gonioscopy and elevated intraocular pressure (IOP) presented with significant asymmetric glaucoma, left eye affected more than right. Initial management with topical medical therapy, laser iridoplasty and peripheral iridotomy in the left eye was ineffective in lowering the IOP or opening the anterior chamber angle. Ultrasound biomicroscopy demonstrated bilateral ciliary body cysts. Read More

Vet Ophthalmol 2018 Sep 3;21(5):535-538. Epub 2017 Oct 3.

Section of Pathology, Department of Clinics and Surgery, Veterinary School, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.

An indoor-only, 5-year-old, spayed female domestic shorthair cat presented for an ophthalmic examination of the left eye. An intraocular tumor with secondary glaucoma and blindness was diagnosed; the globe was enucleated and sent for histopathological examination. Gross examination revealed a solid white mass filling the entire vitreous space and replacing the iris and ciliary body. Read More

Eur J Ophthalmol 2018 Jan;28(1):119-122

1 Department of Ophthalmology, Ocular Tumor Service, The New York Eye and Ear Infirmary of Mount Sinai, New York, New York - USA.

Purpose: To provide a clinical description of the long-term outcome of a Pd plaque-irradiated ciliary body melanoma with extrascleral extension while attempting to preserve a subadjacent glaucoma filtering bleb.

Methods: A 75-year-old woman with pseudoexfoliative glaucoma for 17 years, 16 years status post argon laser trabeculoplasty, and 15 years status post trabeculectomy in the left eye, was diagnosed with an ipsilateral ciliary body melanoma with visible extrascleral extension. Treatment involved insertion of a Pd radioactive plaque over the functioning trabeculectomy, with removal 7 days later. Read More

Cesk Slov Oftalmol 2017 ;73(2):57-60

The value of ICT is important in diagnosis of the diseases of the eye and orbit Methods for direct measurement of intracranial pressure (ICT) are exact, but they are invasive and there is some risk of infection and damage of the tissue. Currently there are 2 valid indirect methods of mesurement of IKT. Digital Ophthalmodynamometry (D-ODM) and Transcranial Doppler ultrasonography (TDU). Read More

Eur J Ophthalmol 2018 Mar 9;28(2):210-215. Epub 2017 Jul 9.

1 Glaucoma Clinic New Delhi, New Delhi - India.

Purpose: Vision loss in Sturge-Weber syndrome (SWS), a rare congenital disorder, is primarily due to glaucoma.

Methods: We reviewed the data of all consecutive SWS-associated glaucoma cases in patients who had undergone combined trabeculotomy-trabeculectomy (CTT) at a tertiary glaucoma facility between January 1993 and December 2015. We analyzed the preoperative and postoperative intraocular pressure (IOP), corneal clarity, visual acuity, success rate, need for repeat surgery, and number of topical antiglaucoma medications needed at last follow-up. Read More

Am J Ophthalmol 2017 Oct 12;182:141-146. Epub 2017 Aug 12.

Department of Ophthalmology, Ninth People's Hospital Affiliated With Shanghai Jiao Tong University School of Medicine, Shanghai, China. Electronic address:

Purpose: To evaluate the intermediate-term efficacy and safety of trabeculotomy in infant Sturge-Weber syndrome (SWS).

Design: Retrospective cohort study.

Methods: All SWS-induced glaucoma patients less than 12 months of age who underwent trabeculotomy at our Ophthalmology Department from August 2011 to March 2017 were reviewed. Read More

Indian J Ophthalmol 2017 Jul;65(7):623-625

Department of Glaucoma, Aravind Eye Hospital and Postgraduate Institute of Ophthalmology, Madurai, Tamil Nadu, India.

A 6-year-old girl presented with blurred vision and was found to have elevated intraocular pressure (IOP) and glaucomatous optic disc damage in both eyes. She also displayed capillary malformations on the face (port-wine stain), upper back and all four limbs, angiomatosis in the brain and had hypertrophy of the left upper and lower limbs typical of overlapping Sturge-Weber syndrome and Klippel-Trenaunay syndromes. She was initially managed with IOP lowering topical medications but required trabeculectomy in the right eye followed by Ahmed valve implantation in both eyes. Read More

Graefes Arch Clin Exp Ophthalmol 2017 Nov 18;255(11):2263-2269. Epub 2017 Jul 18.

Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health; Department of Ophthalmology, Campus Benjamin Franklin, Berlin, Germany.

Purpose: To analyze the risk factors for the development of neovascular glaucoma (NVG) of patients with choroidal melanoma after proton beam therapy (PBT).

Method: Clinical case series, retrospective study. We evaluated 629 consecutive patients receiving proton beam therapy for the treatment of a choroidal melanoma at the oncology service at Charité, Berlin and Helmholtz-Zentrum, Berlin between 05/1998 and 11/2008 regarding the development and risk factors of NVG. Read More

J Curr Ophthalmol 2017 Jun 19;29(2):126-132. Epub 2017 Jan 19.

Eye Research Center, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran.

Purpose: To evaluate and compare the attitudes of ophthalmologists and gynecologists in suggesting appropriate approach to pregnancy in different ocular conditions.

Methods: Specialty-specific questionnaires on delivery mode and abortion indications for ophthalmic patients (refractive, vascular, oncologic, retinal, glaucoma, postoperation, posttrauma, and infectious) were designed and distributed among physician staff of Farabi Eye Hospital and Yas Women Hospital in Tehran. Attitudes and preferences of the ophthalmologists and gynecologists were quantified and compared. Read More

Clin Anat 2018 Jan 15;31(1):68-71. Epub 2017 Sep 15.

Department of Ophthalmology, University Erlangen-Nürnberg, Schwabachanlage 6, Erlangen, 91054, Germany.

Epithelial invasion after open globe injury is a rare complication. Wrong treatment (laser opening of the cyst) or no treatment can lead to painful blindness. Forty percent (25/62) of patients with block excision with epithelial downgrowth had a history of open globe injury. Read More

Melanoma Res 2017 10;27(5):463-468

aDepartment of Ophthalmology, Faculty of Medicine, Comenius University bDepartment of Stereotactic Radiosurgery, St. Elisabeth Cancer Institute, St. Elisabeth University College of Health and Social Work cDepartment of Medical Physics, Faculty of Medicine, Slovak Medical University dDepartment of Information Systems, Faculty of Management, Comenius University, Bratislava, Slovakia.

Long-term results with linear accelerator LINAC-based stereotactic radiosurgery for intraocular uveal malignant melanoma were assessed. A retrospective study was carried out of patients with uveal melanoma after a 1-day session stereotactic radiosurgery at LINAC in Slovakia. In the period 2001-2015, a group of 150 patients with uveal melanoma (139 choroidal melanoma, 11 ciliary body melanoma) was treated. Read More

JAMA Ophthalmol 2017 07;135(7):805-806

Department of Ophthalmology, Duke University, Durham, North Carolina3Byers Eye Institute, Stanford University, Palo Alto, California.

Cesk Slov Oftalmol Fall 2016;72(5):191-194

Iris melanomas are very rare in children. The paper presents the case of a 12-year-old boy with iris melanoma of spindle-cell type A and pre-operatively associated with uncontrolled secondary glaucoma. Tumour resection was complicated by lens extraction and consecutive PC IOL implantation. Read More

JAMA Ophthalmol 2017 04;135(4):391-392

Department of Ophthalmology, Northwestern University Feinberg School of Medicine, Chicago, Illinois.

Surv Ophthalmol 2017 Sep - Oct;62(5):670-676. Epub 2017 Feb 1.

Department of Ophthalmology, Ocular Oncology Service and Ophthalmic Pathology Laboratory, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.

A 19-year-old man noticed blurred vision in his right eye. He had an intraocular pressure of 60 versus 12 mmHg in the fellow eye. He was initially diagnosed with an atypical, advanced pigmentary glaucoma. Read More

J Glaucoma 2017 Feb;26(2):e93-e95

*University of Central Florida College of Medicine, Orlando, FL †Department of Ophthalmology, Kittner Eye Center, University of North Carolina School of Medicine ‡Triangle Ophthalmology, Chapel Hill, NC.

A 64-year-old man who presented with photopsia was found to have elevated intraocular pressure in one eye and optic disc swelling in the other eye. He was initially diagnosed with neurocysticercosis and later metastatic lung adenocarcinoma. The purpose of this paper is to report a rare case of bilateral glare as the first sign of diffusely metastatic cancer and to raise clinical suspicion for systemic malignancy in the presence of multiple ocular manifestations. Read More

Vet Ophthalmol 2018 Mar 17;21(2):205-209. Epub 2017 Jan 17.

School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI, USA.

An eleven-year-old, female spayed Boxer dog was diagnosed with a uveal schwannoma (formerly known as the spindle cell tumor of the blue-eyed dog or SCTBED) despite having a uniformly brown iris. The patient presented to emergency for ocular discomfort, and the right globe was subsequently enucleated due to glaucoma and submitted for histopathology. Upon histopathologic evaluation, a uveal schwannoma was diagnosed and confirmed with immunohistochemical staining. Read More

Int Ophthalmol 2018 Feb 7;38(1):409-416. Epub 2017 Jan 7.

Department of Ophthalmology, Allama Iqbal Medical College/Jinnah Hospital, Lahore, Pakistan.

Purpose: Sturge-Weber syndrome (SWS), also known as encephalotrigeminal angiomatosis, is a condition which includes leptomeningeal hemangioma, facial angiomatosis or nevus flammeus, and ocular changes. SWS can lead to severe complications of anterior segment involving conjunctiva and eyelids, whereas posterior segment of the eye may also be affected by diffuse choroidal hemorrhages. This article was written with the objectives to determine the pathophysiology, diagnosis, and treatment of glaucoma associated with this rare and challenging disorder. Read More

J Clin Oncol 2017 Jan 31;35(1):72-77. Epub 2016 Oct 31.

Rachel C. Brennan, Ibrahim Qaddoumi, Shenghua Mao, Jianrong Wu, Catherine A. Billups, Clinton F. Stewart, Carlos Rodriguez-Galindo, and Matthew W. Wilson, St Jude Children's Research Hospital; and Rachel C. Brennan, Ibrahim Qaddoumi, Clinton F. Stewart, Mary Ellen Hoehn, and Matthew W. Wilson, University of Tennessee Health Science Center, Memphis, TN.

Purpose To evaluate topotecan-based therapy for advanced intraocular retinoblastoma. Patients and Methods Twenty-seven patients with bilateral retinoblastoma (male patients, n = 14; median age, 8.4 months) received chemotherapy: two courses of topotecan plus vincristine followed by three alternating administrations of carboplatin and vincristine for two courses and topotecan plus vincristine for one course, with optional periocular carboplatin. Read More

J Neurosurg 2016 12;125(Suppl 1):58-63

Department of Radiosurgery, Dr. Berezin Medical Centre, St. Petersburg, Russia.

OBJECTIVE The use of Gamma Knife radiosurgery (GKRS) as monotherapy in the treatment of uveal melanoma (UM) allows clinicians to achieve high local tumor control with low recurrence but does not prevent secondary enucleation due to glaucoma in cases of large tumors. The authors analyzed indications for tumor endoresection (ER), the time interval between irradiation and surgery, and the features and results of performing ER for UM after GKRS. METHODS Thirty-seven patients between 28 and 78 years of age (16 male and 11 female patients) with UM underwent GKRS with a dose of 70 to 80 Gy that was applied to the center of the tumor with complete immobilization of the eye during the procedure. Read More

JAMA Ophthalmol 2016 Dec;134(12):1374-1379

Hematology-Oncology Service, Pediatric Hospital S.A.M.I.C. Prof. Dr. Juan P. Garrahan, Buenos Aires, Argentina.

Importance: Fatal metastatic relapse may occur in children with retinoblastoma and high-risk pathologic features (HRPFs). Minimal dissemination (MD) may be an additional tool for risk estimation. The use of cone-rod homeobox (CRX) transcription factor messenger RNA for MD evaluation in metastatic retinoblastoma was previously reported, but no data in nonmetastatic cases with HRPFs are available. Read More

Arch Soc Esp Oftalmol 2017 Aug 13;92(8):379-381. Epub 2016 Oct 13.

Unidad de Tumores Intraoculares, Servicio de Oftalmología y Radioterapia, Hospital Clínico Universitario de Valladolid, Valladolid, España.

Clinical Case: A 35-year-old male with unilateral ocular hypertension in the right eye (RE). Anterior segment examination of the RE showed a melanotic lesion. Intraocular pressure (IOP) was 40mmHg in RE. Read More

Vet Ophthalmol 2017 Nov 20;20(6):551-559. Epub 2016 Jul 20.

Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL, USA.

The objective of this paper is to describe clinical behavior, histopathologic features, and immunohistochemical staining of two-related horses with intraocular teratoid medulloepithelioma. Two-related Quarter Horses with similar intraocular masses presented to the UF-CVM Comparative Ophthalmology Service for evaluation and treatment. The first horse, a 3-year-old gelding, had glaucoma and a cyst-like mass in the anterior chamber. Read More

Invest Ophthalmol Vis Sci 2016 07;57(9):OCT69-79

University of Leicester Ulverscroft Eye Unit, Leicester, United Kingdom.

Purpose: Optical coherence tomography (OCT) has revolutionized the diagnosis and management of adult retinal and optic nerve disease. Children were deprived of this technology until the recent development of handheld spectral-domain OCT (HH-SDOCT). In this article, we review the applications of OCT imaging in pediatric ophthalmology. Read More

J Glaucoma 2016 08;25(8):e741-4

Cole Eye Institute, Cleveland Clinic Foundation, Cleveland, OH.

We report a single case of masquerade glaucoma caused by increased episcleral venous pressure from adnexal lymphoma. The patient presented as a referral for unilateral glaucoma with intraocular pressures (IOPs) consistently >40 mm Hg (right eye). We present data conclusively demonstrating extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue in the involved eye, and provide an account of the treatment of the tumor with sustained regression and complete resolution of his elevated IOP. Read More

Pediatr Dermatol 2016 Jul 9;33(4):e232-4. Epub 2016 Jun 9.

Department of Pediatrics, Cleveland Clinic, Cleveland, Ohio.

Combigan (Allergan, Irvine, CA) is an ophthalmic solution that combines 0.2% brimonidine, a selective α-2 adrenergic agonist, with 0.5% timolol, a nonselective β-adrenergic antagonist. Read More

JAMA Ophthalmol 2016 Aug;134(8):919-23

Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts3Ophthalmic Plastic Surgery, Massachusetts Eye and Ear Infirmary, Boston.

Importance: Medulloepithelioma is the second most common primary neuroepithelial tumor of the eye. The full range of its morphologic expressions and appearances in metastases have not been fully explored.

Observations: A patient in her 50s with glaucoma for decades had undergone multiple filtering surgical procedures, including the placement of a glaucoma drainage device. Read More

Klin Monbl Augenheilkd 2016 Apr 26;233(4):365-8. Epub 2016 Apr 26.

University Hospital Zurich.

Background. Iris defects are mostly acquired after injury, or may be iatrogenic after surgical excision of iris tumours or the result of collateral trauma after anterior segment surgery. They cause severe visual disability, e. Read More

Graefes Arch Clin Exp Ophthalmol 2016 Sep 26;254(9):1779-86. Epub 2016 Apr 26.

Department of Ophthalmology, Medical Faculty Mannheim of the Ruprecht-Karls-University Heidelberg, Heidelberg, Germany.

Purpose: To measure scleral and choroidal volume in eyes of Chinese, and to assess associations with age and axial length.

Methods: We histomorphometrically examined globes from infants and adults which had been enucleated due to retinoblastoma, uveal melanoma, or absolute painful glaucoma. Thickness of sclera and choroid were measured, and volumes were calculated. Read More

Int J Radiat Oncol Biol Phys 2016 May 16;95(1):353-9. Epub 2016 Feb 16.

Northwestern Medicine Chicago Proton Center, Warrenville, Illinois; Proton Collaborative Group.

Purpose: We evaluated sparing of normal structures using 3-dimensional (3D) treatment planning for proton therapy of ocular melanomas.

Methods And Materials: We evaluated 26 consecutive patients with choroidal melanomas on a prospective registry. Ophthalmologic work-up included fundoscopic photographs, fluorescein angiography, ultrasonographic evaluation of tumor dimensions, and magnetic resonance imaging of orbits. Read More

Eye (Lond) 2016 Jun 1;30(6):833-42. Epub 2016 Apr 1.

Department of Ophthalmology, Ocular Oncology and Vitreoretinal Service, Bellvitge University Hospital, Feixa Llarga s/n. L'Hospitalet de Llobregat, Barcelona, Spain.

AimsThe aim of this study was to compare transscleral resection technique performed without hypotensive anaesthesia (TSRWH) with iodine-125 brachytherapy (IBT) in the treatment of choroidal melanoma.Patients and methodsThis was a retrospective surgical cohort study. Nineteen eyes treated with TSRWH were matched with 53 eyes treated with IBT according to: tumour size, distance to fovea, distance to optic nerve, and follow-up time. Read More

Klin Monbl Augenheilkd 2016 Mar 24;232(3):277-83. Epub 2016 Mar 24.

Klinik für Augenheilkunde, Dietrich-Bonhoeffer-Klinikum Neubrandenburg.

Background: Results of a retrospective study of perioperative changes in intraocular pressure (IOP) following radical prostatectomy (RPE) for prostate cancer.

Patients And Methods: In 25 consecutive patients, PSA (prostate specific antigen) and IOP were measured with Goldmann tonometry before and after a mean of 10 days following RPE. The data of three patients with proven glaucoma were evaluated separately. Read More