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J Glaucoma 2022 May 17. Epub 2022 May 17.

Grupo Oftalvist, Alicante , Spain.

Prcis: The PSM® is a safe and effective glaucoma micro-filtering implant that significantly reduces the intraocular pressure, either alone or in combination with phacoemulsification, during the first year after surgery.

Purpose: To assess the safety and efficacy of the Preserflo Microshunt® (PSM®) for the treatment of open angle glaucoma with 0.2▒mg/ml mytomicin C (MMC), either alone or in combination with cataract surgery. Read More

J Clin Med 2022 Apr 30;11(9). Epub 2022 Apr 30.

Department of Ophthalmology, University Hospital of Udine, 33100 Udine, Italy.

Purpose: The aim of this study was to assess the long-term outcomes of canaloplasty surgery in pseudoexfoliation glaucoma (PEXG) patients.

Material And Methods: A total of 116 PEXG patients with an intraocular pressure (IOP) > 21 mm/Hg and maximum tolerated local medical therapy who underwent canaloplasty from February 2008 to January 2022 were considered. Every six months, all subjects underwent a complete ophthalmic examination. Read More

Am J Ophthalmol 2022 May 9. Epub 2022 May 9.

Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida. Electronic address:

Purpose: To identify the factors associated with the complications and failure of gonioscopy-assisted transluminal trabeculotomy (GATT) in children.

Design: retrospective case series METHODS: Setting - institutional Patient - children (age < 18 years) who had undergone GATT Observation procedures - records reviewed, pre- and postoperative intraocular pressures (IOP), extent of angle treated, medications, complications and failure were recorded. Failure was defined as IOP > 21 mmHg or < 5 mmHg, absence of at least 20% IOP reduction, performance of additional IOP-lowering surgery, or loss of light perception vision. Read More

BMC Ophthalmol 2022 May 4;22(1):202. Epub 2022 May 4.

Department of Ophthalmology, the First Affiliated Hospital of Nanjing Medical University, No. 300 Guangzhou Road, Nanjing, 210029, China.

Background: To evaluate the efficacy and safety of modified suture-assisted canaloplasty in Asians with primary open-angle glaucoma (POAG).

Methods: A prospective, consecutive cases study, evaluating a modified canaloplasty by twisted 6/0 suture was performed on Asian POAG patients. Three modifications of this canaloplasty included opening the Schlemm's canal by viscocanalostomy, circumferential probing by a twisted 6/0 suture and loose suture of the superficial scleral flap. Read More

Clin Ophthalmol 2022 21;16:1225-1234. Epub 2022 Apr 21.

Clinical Development, Sight Sciences, Menlo Park, CA, USA.

Purpose: To report 12-month efficacy outcomes of 360° canaloplasty and 180° trabeculotomy using the OMNI surgical system in combination with phacoemulsification in patients with mild-moderate open-angle glaucoma (OAG) and visually significant cataract.

Setting: Fifteen multi-subspecialty ophthalmology practices and surgery centers located in 14 US states.

Design: Prospective, multicenter, IRB approved study of patients treated with canaloplasty (360°) and trabeculotomy (180°). Read More

Am J Ophthalmol Case Rep 2022 Jun 12;26:101537. Epub 2022 Apr 12.

Francis I. Proctor Foundation, University of California San Francisco, San Francisco, CA, USA.

Purpose: To describe uveitis-glaucoma-hyphema (UGH) syndrome secondary to a posterior chamber intraocular lens (PCIOL) within the capsular bag in which pathogenic changes to the ciliary body were observed and treated with endocyclophotocoagulation (ECP).

Observations: An 85-year-old woman who had cataract surgery in her right eye four years ago presented with recurrent, unilateral, open-angle, hypertensive uveitis in her right eye. Her presentations were characterized by decreased vision, elevated intraocular pressure, corneal edema, a mixed anterior chamber reaction, and pigmented anterior vitreous cells. Read More

J Vet Cardiol 2022 Mar 23;41:209-215. Epub 2022 Mar 23.

Langford Vets, University of Bristol, Stock Lane, Lower Langford, North Somerset, BS40 5DU, United Kingdom; Highcroft Veterinary Referrals, 615 Wells Road, Whitchurch, Bristol, Avon, BS14 9BE, United Kingdom. Electronic address:

A six-year-seven-month-old female neutered Cavalier King Charles Spaniel was referred for the investigation of progressive dyspnea and hyphema in the right eye with secondary glaucoma. Previous medical history included a high-grade soft tissue spindle cell sarcoma removed from the cranial sternal region one year before. On presentation at the referral hospital, the dog was tachypneic and dyspneic. Read More

J AAPOS 2022 Apr 14. Epub 2022 Apr 14.

Farabi Eye Hospital, Tehran, Iran.

Purpose: To investigate the outcome of viscocanalostomy combined with trabeculotomy (VCO+tbo) in primary congenital glaucoma (PCG) with history of failed trabeculotomy.

Methods: In this prospective study, VCO+tbo was performed in 75 eyes of 46 patients with PCG who had not responded adequately to one angle surgery. Success was defined as intraocular pressure (IOP) of 6-21 mm Hg and at least 20% IOP drop at the last postoperative visit with (qualified) or without (complete) glaucoma medications. Read More

Int Ophthalmol 2022 Apr 13. Epub 2022 Apr 13.

Department of Ophthalmology, Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Kongjiang Road, No. 1665, Shanghai, 200092, China.

Purpose: To investigate the clinical features and surgical outcomes in infants with glaucoma secondary to a special anterior-anterior type of persistent fetal vasculature (AAPFV).

Methods: This study retrospectively reviewed the medical records of infants who underwent of the synechialysis, pupilloplasty, with or without lensectomy and limbal vitrectomy due to AAPFV and with at least 6 months of postoperative follow-up.

Results: Eleven patients were included. Read More

Zhonghua Yan Ke Za Zhi 2022 Apr;58(4):279-288

Eye Center, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou 310009, China.

To evaluate the preliminary efficacy and safety of ab interno canaloplasty (ABiC) combined with micro-incision cataract surgery for treating primary open angle glaucoma (POAG) combined with cataract. Prospective case series study. Patients diagnosed with POAG and concurrent cataract were enrolled to receive ABiC combined with micro-incision phacoemulsification and intraocular lens implantation in the Eye Center of the Second Affiliated Hospital of Zhejiang University School of Medicine from June 2018 to October 2019. Read More

Oman J Ophthalmol 2022 Jan-Apr;15(1):31-35. Epub 2022 Mar 2.

Glaucoma Research Center, Wills Eye Hospital, Philadelphia, Pennsylvania, USA.

Objective: To compare the surgical outcomes and early postoperative complications of Ahmed glaucoma valve (AGV) implantation performed by residents with those performed by attending physicians.

Methods: This is a retrospective, case-control study. Data were gathered from chart reviews of consecutive cases of AGV model FP7 implantation between January 2014 and July 2017. Read More

Retin Cases Brief Rep 2022 Apr 1. Epub 2022 Apr 1.

University of Hawaii John A Burns School of Medicine, Honolulu, Hawaii.

Purpose: To describe a case of successful resolution of severe hypotony and choroidal detachments following non-filtering glaucoma surgery with an intravitreal injection of C3F8 gas after a poor response to topical steroids and cycloplegia.

Methods: Retrospective chart review of a case report.

Patient: 89 year-old male. Read More

Front Oncol 2022 15;12:768635. Epub 2022 Mar 15.

Beijing Tongren Eye Center, Beijing Key Laboratory of Intraocular Tumor Diagnosis and Treatment, Medical Artificial Intelligence Research and Verification Laboratory of the Ministry of Industry and Information Technology, Beijing Tongren Hospital, Capital Medical University, Beijing, China.

Objective: To describe the outcome of intraocular tumor resection by partial transscleral sclerouvectomy (PTSU) combined with micro-invasive vitrectomy and reconstruction of the eyeball (MVRE) in Asian patients.

Design Methods And Participants: This retrospective, interventional cohort study included 366 patients who underwent PTSU combined with MVRE for intraocular tumors both in adult and pediatric age groups. The medical records of these patients were reviewed for clinical, operative, and histopathological features. Read More

Br J Ophthalmol 2022 Apr 1. Epub 2022 Apr 1.

Faculty of Life Sciences & Medicine, King's College London, London, UK

Background/aims: To evaluate the efficacy and safety of the PreserFlo MicroShunt glaucoma device in a multicentre cohort study.

Methods: All consecutive patients who received the microshunt with mitomycin-C (MMC) 0.4 mg/mL from May 2019 to September 2020 in three UK tertiary centres. Read More

J Glaucoma 2022 Mar 29. Epub 2022 Mar 29.

Department of Ophthalmology, Federal University of São Paulo, São Paulo, Brazil.

Prcis: Our results suggest gonioscopy-assisted transluminal trabeculotomy (GATT) as an effective and safe option for the surgical management of open-angle glaucoma. Older age was the only risk factor for failure in our analysis.

Purpose: To report 12-month clinical outcomes, safety profile and success predictors of gonioscopy-assisted transluminal trabeculotomy (GATT) in patients with open-angle glaucoma (OAG). Read More

Case Rep Ophthalmol 2022 Jan-Apr;13(1):82-88. Epub 2022 Feb 14.

Ross Eye Institute, University at Buffalo, Buffalo, New York, USA.

Minimally invasive glaucoma surgery (MIGS) is a subset of glaucoma surgery that is known for its low rate of complications both intraoperatively and postoperatively compared to traditional filtering surgery. We present a case of a patient who, after receiving uncomplicated cataract extraction with posterior chamber intraocular lens implantation and concurrent iStent trabecular bypass stent implantation, experienced recurrent episodes of spontaneous microhyphema and inflammation in the late postoperative period. The patient, who had a history of mild asymmetric exfoliative glaucoma but no identifiable sources of trauma, underwent extensive examination to investigate causes of his episodic anterior segment bleeding and mild inflammation with concurrent elevated intraocular pressure. Read More

Eye (Lond) 2022 Mar 28. Epub 2022 Mar 28.

Department of Ophthalmology, Tan Tock Seng Hospital, National Healthcare Group Eye Institute, Singapore, Singapore.

Background: The XEN45 Gel Stent is a subconjunctival filtering device that has demonstrated promising efficacy. This meta-analysis quantitatively evaluates reported complications and interventions after XEN45 implantation in the treatment of open angle glaucoma (OAG).

Methods: Pilot, cohort, observational studies, and randomised controlled trials that included at least ten patients undergoing ab interno or externo XEN45 surgery, with or without phacoemulsification were deemed eligible for inclusion. Read More

Am J Ophthalmol Case Rep 2022 Jun 17;26:101492. Epub 2022 Mar 17.

El Paso Eye Surgeons, P.A, 1201 N. Mesa, Ste G., El Paso, TX, 79902, USA.

Purpose: To describe the management of a case of chronic, recurrent hyphema following excisional goniotomy with the Kahook Dual Blade.

Observations: One week following uncomplicated surgery, the patient presented with eye pain, elevated intraocular pressure, and layered hyphema. The hyphema resolved with conservative measures but recurred several times with similar symptoms over the next several months. Read More

Can J Ophthalmol 2022 Mar 23. Epub 2022 Mar 23.

Department of Ophthalmology, University of Montreal Hospital Centre, Montréal, Que.; Department of Ophthalmology, Queen's University, Kingston, Ont.. Electronic address:

Objective: To evaluate the outcomes of ab interno gelatin microstent implantation alone and in combination with phacoemulsification for the reduction of intraocular pressure (IOP).

Design: Retrospective cohort study.

Participants: 141 eyes of 141 patients with any glaucoma subtype, including refractory glaucoma, operated in the Centre Hospitalier de l'Université de Montréal (CHUM) from 2015-2018. Read More

Arq Bras Oftalmol 2022 Mar 21. Epub 2022 Mar 21.

Faculty of Medicine, Mansoura University, Mansoura, Egypt.

Purpose: To compare viscotrabeculotomy with anterior chamber irrigation to Ahmed glaucoma valve implantation for secondary glaucoma following silicone oil removal.

Methods: A prospective study was conducted on 43 vitrectomized pseudophakic eyes with persistent glaucoma after silicone oil removal. Patients were randomized to either viscotrabeculotomy with anterior chamber irrigation or Ahmed glaucoma valve implantation. Read More

Br J Ophthalmol 2022 Mar 22. Epub 2022 Mar 22.

Eye Hospital and School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou, Zhejiang, China

Background/aim: To evaluate the clinical outcomes of penetrating canaloplasty in traumatic angle recession glaucoma at 1 year.

Methods: Patients with angle recession glaucoma underwent penetrating canaloplasty, a new Schlemm's canal-based internal drainage procedure, which creates a direct canal for flow of aqueous humour from the anterior chamber to the ostia of Schlemm's canal via a window created at the corneal scleral bed without use of antimetabolites. Postoperative intraocular pressure (IOP), number of glaucoma medications, and procedure-related complications were evaluated. Read More

J Glaucoma 2022 May 7;31(5):335-339. Epub 2022 Mar 7.

Mayo Clinic College of Medicine, Jacksonville, FL.

Prcis: Designed with novel features to facilitate implantation and improve safety, the Ahmed ClearPath (ACP) glaucoma drainage device (GDD) provided intraocular pressure (IOP) reduction comparable with other GDDs in eyes with refractory glaucoma in a multicenter retrospective study.

Purpose: To present clinical outcomes with a novel valveless GDD (ACP, New World Medical). The 250 and 350 mm2 models feature a contoured plate for optimal globe apposition, anteriorized suture points to facilitate suturing to the globe, and a prethreaded 4-0 polypropylene ripcord suture. Read More

Cornea 2022 Mar 5. Epub 2022 Mar 5.

Dean McGee Eye Institute, University of Oklahoma Health Sciences Center, Oklahoma City, OK; and Hudson College of Public Health, University of Oklahoma, Oklahoma City, OK.

Purpose: The purpose of this study was to report clinical outcomes of ab interno canaloplasty (ABiC) with the iTrack microcatheter (Nova Eye Medical, Fremont, CA) for surgical management of intraocular pressure (IOP) in postkeratoplasty patients.

Methods: This study was a single-center retrospective case series of postkeratoplasty eyes undergoing ABiC. Efficacy was evaluated based on graft survivability and mean reduction in IOP at 12 months postoperatively. Read More

Am J Ophthalmol Case Rep 2022 Mar 9;25:101405. Epub 2022 Feb 9.

Department of Ophthalmology, Sue Anschutz-Rodgers Eye Center, University of Colorado School of Medicine, Aurora, CO, USA.

Intraocular implants, specifically those used in the treatment of glaucoma, are each associated with various implant related risks and complications of which surgeons placing these devices must be aware. Here we present a case of uveitis-glaucoma-hyphema (UGH) syndrome associated with the Hydrus Microstent. Read More

J Clin Med 2022 Jan 29;11(3). Epub 2022 Jan 29.

Department of Ophthalmology and Visual Science, Kochi Medical School, Kochi University, Nankoku 783-8505, Japan.

The purpose of this study was to compare the clinical outcomes of ab interno microhook trabeculotomy (µLOT) before and after cataract surgery for the combination of µLOT and cataract surgery. This retrospective case series included 40 eyes that underwent µLOT combined with cataract surgery at Kochi University Hospital. Groups 1 (20 eyes) and 2 (20 eyes) included eyes that underwent µLOT before and after cataract surgery, respectively. Read More

J Glaucoma 2022 Apr;31(4):268-273

Sheffield Teaching Hospital NHS Foundation Trust, Sheffield, UK.

Prcis: Irrigating goniectomy with the TrabEx+ device can lower intraocular pressure (IOP) in patients with glaucoma, as a standalone procedure or combined with cataract surgery.

Purpose: The aim was to describe the efficacy and safety of irrigating goniectomy performed using the TrabEx+ device, either as a standalone procedure or combined with cataract surgery, in eyes with medically treated open-angle glaucoma.

Methods: A retrospective case series of eyes treated by a single surgeon at a single UK teaching hospital. Read More

Am J Ophthalmol Case Rep 2022 Mar 20;25:101296. Epub 2022 Jan 20.

University of Florida Ophthalmology Department, USA.

Purpose: To report a case of the resolution of Uveitis-Glaucoma-Hyphema (UGH) Syndrome after a solid state 532 nm frequency-doubled neodymium-doped yttrium aluminum garnet (Nd:YAG) laser iridoplasty guided by temporary conjunctival markings.

Design: Interventional Case Report.

Methods: In a case of UGH Syndrome in a 79 year-old male, the decision was made to perform a Nd:YAG laser iridoplasty guided by temporary conjunctival markings along the transilluminated defects created from the IOL haptic. Read More

Rom J Ophthalmol 2021 Oct-Dec;65(4):395-398

Department of Ophthalmology, San Cecilio University Hospital, Granada, Spain.

To report a case of retinal detachment (RD) in a UGH Syndrome after cataract surgery and to emphasize special aspects of the management, along with factors that must be considered. We present the case of a 56-year-old man who underwent cataract surgery with a capsulorhexis leak, but the implantation of the lens in the sac did not hinder. 8 months after surgery, he presented several episodes of hypertensive uveitis that produced a progression in the excavation of the optic nerve head from 3/10 to 9/10 despite the treatment with ocular hypotensive drugs. Read More

Front Med (Lausanne) 2021 10;8:766032. Epub 2022 Jan 10.

Experimental Teaching Center for Clinical Skills, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.

This study investigates the safety and efficacy of conbercept injection through different routes for neovascular glaucoma (NVG) treatment, in which seventy-four patients (81 eyes) with NVG caused by ischemia retinopathy had participated. Patients were divided into three stages according to the progression of NVG and were randomly assigned to receive intracameral or intravitreal conbercept injection. After conbercept injection, patients experienced improved best-corrected visual acuity (BCVA), good intraocular pressure (IOP) control, and neovascularization of Iris (NVI) regression. Read More