66,593 results match your criteria Glaucoma Drug-Induced


Patient Reported Outcomes, Functional Assessment and Utility Values in Glaucoma.

J Glaucoma 2018 Dec 11. Epub 2018 Dec 11.

Johns Hopkins Wilmer Eye Institute, Maryland USA.

In clinical glaucoma research, the measurement of patient reported outcomes, functional assessment of disability, and health economic impact is critical. However, valid, time-efficient and comprehensive tools are not available and several current instruments lack in the appropriate precision for measuring the various dimensions of glaucoma-related quality of life (QoL), including functioning and mobility. Furthermore, statistical methods are inconsistently and sometimes incorrectly used in otherwise sound clinical studies. Read More

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December 2018

Effect of Mannitol on Intraocular Pressure in Vitrectomized and Non-vitrectomized Eyes: A Prospective Comparative Study.

J Glaucoma 2018 Dec 11. Epub 2018 Dec 11.

Glaucoma Services, Aravind Eye Hospital, Coimbatore, India.

Purpose: To compare the effect of mannitol in reducing intraocular pressure (IOP) in vitrectomized and non-vitrectomized eyes.

Methods: Prospective comparative case study. Eyes with IOP ≥40▒mm Hg were included. Read More

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December 2018

Re: Radke et al - The Translaminar Pressure Gradient - Papilledema After Trabeculectomy Treated With Optic Nerve Sheath Fenestration.

Authors:
David Fleischman

J Glaucoma 2018 Dec 11. Epub 2018 Dec 11.

Department of Ophthalmology, University of North Carolina at Chapel Hill.

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December 2018

Management of Tube Exposure Following Ahmed Glaucoma Valve Implantation by Allograft Corneoscleral Rim Patch.

J Glaucoma 2018 Dec 11. Epub 2018 Dec 11.

Glaucoma Services, Department of Ophthalmology, GSVM Medical College, Kanpur, UP (India).

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December 2018

Hypohidrotic Ectodermal Dysplasia: A Rare Disorder with Bilateral Infantile Glaucoma.

J Glaucoma 2018 Dec 11. Epub 2018 Dec 11.

Glaucoma and anterior segment, Dr. Shroff's charity eye hospital, Delhi.

Ectodermal dysplasia is a disorder that occurs due to abnormalities of ectodermal structures such as skin, teeth, hair, nails, and eccrine glands. Approximately 200 different conditions have been identified as ectodermal dysplasia, the most common being hypohidrotic ectodermal dysplasia (HED). It is characterized by hypotrichosis (sparse scalp or body hair), hypodontia (absent or malformed teeth) and hypohidrosis (reduced ability to sweat). Read More

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December 2018
1 Read

imaging of structural, metabolic and functional brain changes in glaucoma.

Neural Regen Res 2019 Mar;14(3):446-449

NYU Langone Eye Center, Department of Ophthalmology, NYU School of Medicine, NYU Langone Health; Department of Radiology, NYU School of Medicine, NYU Langone Health; Center for Neural Science, Faculty of Arts and Science, New York University, New York, NY, USA.

Glaucoma, the world's leading cause of irreversible blindness, is a condition for which elevated intraocular pressure is currently the only modifiable risk factor. However, the disorder can continue to progress even at reduced intraocular pressure. This indicates additional key factors that contribute to the etiopathogenesis. Read More

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Basics on the use of acid-sensing ion channels' inhibitors as therapeutics.

Neural Regen Res 2019 Mar;14(3):395-398

North Texas Eye Research Institute, Department of Pharmacology and Neuroscience, University of North Texas Health Science Center at Fort Worth, Fort Worth, TX, USA.

Since the discovery of acid-sensing ion channels in 1997, their importance in the health of neurons and other non-neuronal cells has gained significant importance. Acid-sensing ion channels play important roles in mediating pain sensation during diseases such as stroke, inflammation, arthritis, cancer, and recently migraine. More interestingly, acid-sensing ion channels may explain the sex differences in pain between males and females. Read More

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Neuroinflammation as a target for glaucoma therapy.

Neural Regen Res 2019 Mar;14(3):391-394

Visual Neurophysiology and Neurophthalmology Research Unit, IRCCS G.B. Bietti Foundation, Roma, Italy.

The pathogenesis of glaucoma is still not fully clarified but a growing body of evidence suggests that neuroinflammation and immune response are part of the sequence of pathological events leading to the optic neuropathy. Indeed, inflammation - involving the activation and proliferation of resident glial cells (astrocytes, Muller cells and microglia) and the release of a plethora of anti- and pro-inflammatory cytokines, chemokines and reactive oxygen species - has been reported as common features in clinical and experimental glaucoma. In the insulted retina, as for other neuronal tissues, pathogenic and reparative aspects coexist in the inflammatory process, with extent and persistency affecting the final outcome. Read More

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Intraocular lens dislocation: a novel in-situ scleral refixation technique using a 25 Gauge trocar in the anterior chamber.

BMJ Open Ophthalmol 2018 23;3(1):e000174. Epub 2018 Nov 23.

Dipartimento Neuromuscoloscheletrico e Organi di Sensi, Università degli Study di Firenze, Florence, Italy.

Objective: Intraocular lens (IOL) repositioning using a closed-eye approach could be carried out in some selected cases. Our study focuses on the efficacy and safety of a IOL closed-eye repositioning technique using scleral suture, which is performed using a trocar as an intrastromal limbal guide.

Methods And Analysis: Thirty-one eyes of 31 patients with late IOL dislocation operated on between January 2015 and May 2017 were included in this retrospective non-comparative consecutive case series study. Read More

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November 2018

In glaucoma patients, low blood pressure is accompanied by vascular dysregulation.

EPMA J 2018 Dec 12;9(4):387-391. Epub 2018 Nov 12.

Department of Ophthalmology, University of Basel, Mittlere Strasse 91, CH-4031 Basel, Switzerland.

Background: There are many risk factors contributing to glaucomatous optic neuropathy. Beside increased intraocular pressure, vascular factors play a prominent role, particularly low blood pressure (BP), and vascular dysregulation. Both of them are essential components of the Flammer syndrome. Read More

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December 2018

Better tolerance of preservative-free latanoprost compared to preserved glaucoma eye drops: the 12-month real-life FREE study.

Clin Ophthalmol 2018 26;12:2399-2407. Epub 2018 Nov 26.

Department of Ophtalmology, Claude Huriez Hospital, University Hospital, Lille, France.

Background: Lack of efficacy due to bad compliance caused by intolerance issues is the main reason for a change to a better tolerated ocular treatment, such as using preservative-free (PF) eye drops.

Aim: To assess the efficacy and local tolerance after 12 months and patient satisfaction regarding local treatment tolerance and handling at inclusion and after 6 months of PF latanoprost compared to preserved glaucoma eye drops.

Methods: This was an international, prospective, and observational real-life study. Read More

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November 2018

Efficacy of the travoprost/timolol fixed combination versus the concomitant use of travoprost 0.004% and timolol 0.1% gel formulation.

Clin Ophthalmol 2018 23;12:2393-2398. Epub 2018 Nov 23.

University of Alcala, Madrid, Spain.

Purpose: To compare the hypotensive effect of travoprost 0.004%/timolol 0.5% fixed combination (TTFC) to the concomitant use of travoprost and timolol 0. Read More

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November 2018

Safety of high-dose intravitreal triamcinolone acetonide as low-cost alternative to anti-vascular endothelial growth factor agents in lower-middle-income countries.

Clin Ophthalmol 2018 26;12:2383-2391. Epub 2018 Nov 26.

Department of Ophthalmology, Faculty of Medicine, Benha University, Benha, Egypt.

Purpose: The purpose of this study was to evaluate the safety of high-dose intravitreal triamcinolone acetonide (IVTA) as affordable low-cost alternative to anti-vascular endothelial growth factor (anti-vascular endothelial growth factor [anti-VEGF] agents) in lower-middle-income countries.

Patients And Methods: This was a retrospective interventional non-comparative case series. The study recruited patients who received 20 mg IVTA for treating various retinal and optic nerve diseases over the past 5 years. Read More

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November 2018

Synthesis and characterization of novel substituted thiophene derivatives and discovery of their carbonic anhydrase and acetylcholinesterase inhibition effects.

J Biochem Mol Toxicol 2018 Dec 10:e22261. Epub 2018 Dec 10.

Department of Chemistry, Faculty of Science, Ataturk University, Erzurum, Turkey.

Novel substituted thiophene derivatives (1, 2a-e, 3, and 4) were synthesized and their structures were characterized by infrared radiation, nuclear magnetic resonance, and mass analysis. These novel substituted thiophene derivatives were effective inhibitor compounds of the carbonic anhydrase I and II isozymes (hCA I and II), and acetylcholinesterase (AChE) enzyme with K values in the range of 447.28 to 1004. Read More

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December 2018
1.925 Impact Factor

Thermo-sensitive nanogel-laden bicontinuous microemulsion drug-eluting contact lenses.

J Biomed Mater Res B Appl Biomater 2018 Dec 7. Epub 2018 Dec 7.

Department of Biomedical Engineering, School of Medicine, Catholic University of Daegu, Daegu, 42472, South Korea.

The bicontinuous microemulsion contact lens (BMCL) has nanoporous biphasic structures (100-250 nm) that are interconnected via multiple nano-channels, providing suitable retention of various drugs for glaucoma. Timolol maleate (TM)-carried thermosensitive poly(N-isopropylacrylamide) (PNIPAM) nanogel (30-50 nm) was incorporated into BMCLs by soaking or by centrifuging plus soaking. Here, we present drug-loading and release in silicon- or polyethylene oxide-microemulsion BMCLs under various conditions. Read More

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December 2018

Non-linear Relationship between Blood Pressure and Glaucoma in US Adults.

Am J Hypertens 2018 Dec 8. Epub 2018 Dec 8.

Department of Medicine and Program in Public Health, University of California, Irvine, USA.

Background: Previous studies have reported that vascular disease is associated with glaucoma. However, the relationship between blood pressure (BP) and glaucoma has been inconsistent. We investigated whether there is a non-linear association between BP and glaucoma in an adult population of the United States. Read More

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December 2018
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Genome-wide association analyses identify 139 loci associated with macular thickness in the UK Biobank cohort.

Hum Mol Genet 2018 Dec 7. Epub 2018 Dec 7.

Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, IL, USA.

The macula, located near the center of the retina in the human eye, is responsible for providing critical functions, such as central, sharp vision. Structural changes in the macula are associated with many ocular diseases, including age-related macular degeneration (AMD) and glaucoma. Although macular thickness is a highly heritable trait, there are no prior reported genome-wide association studies (GWASs) of it. Read More

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December 2018

[A model of ophthalmological network care including primary care centers and a tertiary care hospital].

Rev Med Chil 2018 Aug;146(8):890-893

Servicio de Oftalmología, Hospital del Salvador, Santiago, Chile.

Background: Primary care units of ophtalmology (UAPO) were incorporated in 2003 into the healthcare system of the Ministry of Health, in response to the high demand for hospital care. Three of these primary care units were incorporated to provide a network care with the ophthalmology service of a tertiary care hospital.

Aim: To report the public health impact of networking. Read More

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New perspectives in the use of laser diode transscleral cyclophotocoagulation. A prospective single center observational cohort study.

Rom J Morphol Embryol 2018 ;59(3):869-872

Department of Neurology, "Victor Babeş" University of Medicine and Pharmacy, "Pius Brînzeu" Emergency County Clinical Hospital, Timişoara, Romania; Department of Ophthalmology, "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania;

Purpose: The paper intends to present the results of using new methods of a new generation diode laser transscleral cyclophotocoagulation (TSCPC) in patients with different types of glaucoma.

Patients, Materials And Methods: There have been treated 53 eyes from 59 patients with glaucoma refractory to medical, laser or surgical treatment. We have used the newest generation of 810 nm wavelength diode laser. Read More

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January 2018

Human stem cells home to and repair laser-damaged trabecular meshwork in a mouse model.

Commun Biol 2018 6;1:216. Epub 2018 Dec 6.

1Department of Ophthalmology, University of Pittsburgh, Pittsburgh, PA 15213 USA.

Glaucoma is the leading cause of irreversible vision loss, and reducing elevated intraocular pressure is currently the only effective clinical treatment. The trabecular meshwork is the main resistance site for aqueous outflow that maintains intraocular pressure. In this study, we transplanted human trabecular meshwork stem cells (TMSCs) intracamerally into mice that received laser photocoagulation over a 180° arc of the trabecular meshwork. Read More

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December 2018

Is a Day 1 postoperative review following ab interno Xen gel stent surgery for glaucoma needed?

Clin Ophthalmol 2018 15;12:2331-2335. Epub 2018 Nov 15.

Department of Ophthalmology, Royal Surrey County Hospital, Guildford, UK,

Purpose: To assess whether a first day review is needed following Xen surgery in glaucoma patients.

Patients And Methods: We performed a retrospective case note review of all Xen surgeries performed across four centers between August 2015 and May 2017. Intraocular pressure (IOP), number of medications, complications, and all further procedures were recorded. Read More

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November 2018

Risk factors for neovascular glaucoma after vitrectomy in eyes with proliferative diabetic retinopathy.

Clin Ophthalmol 2018 14;12:2323-2329. Epub 2018 Nov 14.

Department of Ophthalmology, Toho University Sakura Medical Center, Shimoshizu, Sakura, Japan,

Purpose: To investigate the potential risk factors for neovascular glaucoma (NVG) after vitrectomy in eyes with proliferative diabetic retinopathy.

Subjects And Methods: In this retrospective, observational, comparative study, patients with proliferative diabetic retinopathy who underwent vitrectomy at Toho University Sakura Medical Center between December 2011 and November 2016 and who were followed for ≥12 months after surgery were included. Subject parameters examined included age, glycated hemoglobin (HbA1c), fasting blood glucose, administration of insulin, and estimated glomerular filtration rate. Read More

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November 2018

Masking of Papilledema by Glaucoma.

Ann Indian Acad Neurol 2018 Oct-Dec;21(4):330-331

Department of Cornea and IOL, AG Eye Hospital, Trichy, Tamil Nadu, India.

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December 2018

Non-GVHD ocular complications after hematopoietic cell transplantation: expert review from the Late Effects and Quality of Life Working Committee of the CIBMTR and Transplant Complications Working Party of the EBMT.

Bone Marrow Transplant 2018 Dec 7. Epub 2018 Dec 7.

Department of Ophthalmology, Hospital Universitario Puerta de Hierro, Madrid, Spain.

Non-graft-vs.-host disease (non-GVHD) ocular complications are generally uncommon after hematopoietic cell transplantation (HCT), but can cause prolonged morbidity affecting activities of daily living and quality of life. Here we provide an expert review of non-GVHD ocular complications in a collaboration between transplant physicians and ophthalmologists through the Late Effects and Quality of Life Working Committee of the Center for International Blood and Marrow Transplant Research and the Transplant Complications Working Party of the European Society of Blood and Marrow Transplantation. Read More

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December 2018

Evaluation of episcleral venous fluid wave during gonioscopy assisted transluminal trabeculotomy in patients with advanced glaucoma.

Eye (Lond) 2018 Dec 10. Epub 2018 Dec 10.

Gazi University, Faculty of Medicine, Department of Ophthalmology, Ankara, Turkey.

Purpose: To evaluate episcleral venous fluid wave (EVFW) during GATT surgery in patients with advanced stage open angle glaucoma and to investigate its relationship with the severity of glaucoma.

Methods: In all, 34 eyes of 28 open angle glaucoma patients who underwent GATT surgery were included into study. The extent of EVFW was evaluated using surgical records of patients and it was defined as number of clock hours. Read More

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December 2018

COMPARATIVE EVALUATION OF ANTERIOR SEGMENT OPTICAL COHERENCE TOMOGRAPHY, ULTRASOUND BIOMICROSCOPY, AND INTRAOCULAR PRESSURE CHANGES AFTER PANRETINAL PHOTOCOAGULATION BY PASCAL AND CONVENTIONAL LASER.

Retina 2018 Nov 28. Epub 2018 Nov 28.

Glaucoma Services, Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India.

Purpose: To compare intraocular pressure, anterior segment optical coherence tomography, and ultrasound biomicroscopy parameters over 3 months after panretinal photocoagulation (PRP) for proliferative diabetic retinopathy after 1 of 2 sittings by conventional laser (half PRP) and a single sitting of Pattern Scan Laser (PASCAL) PRP.

Methods: This was a prospective, randomized, interventional study. All tests were performed at baseline, and at 1, 6, and 24 hours, and 1, 4, 8, and 12 weeks after PRP. Read More

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November 2018

Predicting the Therapeutic Efficacy of Laser Peripheral Iridotomy for Individuals with Asymptomatic Narrow Angle: The Triple Hump Sign.

J Glaucoma 2018 Dec 10. Epub 2018 Dec 10.

Department of Ophthalmology, Seoul National University College of Medicine, Seoul, Korea.

Purpose: To evaluate the clinical efficacy of a novel screening sign (i.e., the Triple Hump [TH] sign) for prediction of laser peripheral iridotomy (LPI)'s intraocular pressure (IOP)-lowering effectiveness in subjects with asymptomatic narrow angles. Read More

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December 2018

Short-term Optic Disc Cupping Reversal in a Patient with Mild Juvenile Open-angle Glaucoma Due to Early Idiopathic Intracranial Hypertension.

J Glaucoma 2018 Dec 10. Epub 2018 Dec 10.

Vanderbilt Eye Institute, Vanderbilt University Medical Center, 2311 Pierce Avenue, Nashville, TN, 37232.

Purpose: The purpose of this study is to report a case of optic disc cupping reversal in an adult without significant intraocular pressure lowering treatment.

Patient: A 20-year-old female with a history of mild juvenile open-angle glaucoma who developed subjective blurred vision and a decrease in cupping of her optic discs.

Results: Dilated examination demonstrated decreased cup-to-disc ratios in both eyes with slight blurring of the disc margin in the right eye. Read More

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December 2018

Ahmed Glaucoma Valve Revision versus Visco-Trabeculotomy After Failed Ahmed Glaucoma Valve in Refractory Pediatric Glaucoma.

J Glaucoma 2018 Dec 10. Epub 2018 Dec 10.

Ophthalmology. Faculty of Medicine. Alexandria University. Alexandria, Egypt.

Purpose: To compare the outcome on the IOP of Ahmed Glaucoma Valve (AGV) revision to Visco-trabeculotomy (VT) in children eyes with failed AGV.

Patients And Methods: A prospective randomized study conducted on 41 children (41 eyes) with uncontrolled glaucoma with an AGV presenting to the pediatric ophthalmology clinic of Mansoura Ophthalmic Center between 2011 and 2016. Study eyes were randomized to AGV revision or VT. Read More

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December 2018

Prediction of Surgical Outcome After Trabeculectomy for Neovascular Glaucoma With Anterior-segment Optical Coherence Tomography: A Methodological Issues.

J Glaucoma 2018 Dec 10. Epub 2018 Dec 10.

Department of operating room, School of Paramedical, Kermanshah University of Medical Sciences, Kermanshah, I.R. Iran.

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December 2018

Early Phacoemulsification After Acute Angle Closure in Patients With Coexisting Cataract.

J Glaucoma 2018 Dec 10. Epub 2018 Dec 10.

University Eye Clinic Maastricht, Maastricht University Medical Center+, Maastricht, the Netherlands.

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December 2018

Glaucoma Work-up in Congenital Zika Syndrome.

J Glaucoma 2018 Dec 10. Epub 2018 Dec 10.

Department of Ophthalmology and Visual Sciences, Federal University of Sa[Combining Tilde]o Paulo, Sa[Combining Tilde]o Paulo, Brazil.

Purpose: To perform a glaucoma work-up in infants with congenital Zika syndrome (CZS).

Patient And Methods: This cross-sectional study included 188 eyes of 107 children (1.1 ± 0. Read More

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December 2018

Evidence on neuroprotective properties of coenzyme Q10 in the treatment of glaucoma.

Neural Regen Res 2019 Feb;14(2):197-200

Ophthalmology Unit, Department of Experimental Medicine, University of Rome Tor Vergata, Rome, Italy.

Glaucoma, the leading cause of visual impairment and irreversible blindness worldwide, is a multifactorial, progressive optic neuropathy characterized by loss of retinal ganglion cells, alterations of the optic nerve head, and specific visual field defects. Clinical evidence shows that intraocular pressure is the major risk factor of the treatable disease. However, in some patients, glaucoma develops and continues to progress despite normal intraocular pressure values, suggesting that other risk factors are involved in the disease. Read More

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February 2019

Laser Acupuncture in Open-Angle Glaucoma Treatment A Retrospective Study of Eye Blood Flow.

J Acupunct Meridian Stud 2018 Dec 6. Epub 2018 Dec 6.

Medical Devices R&D, Freelance Researcher (Genova - Italy), Sal. Maggiolo di Nervi, 7 16167 Genova - Italy. Electronic address:

Glaucoma patients can show blood flow anomalies at the eye vessels' level. A causal relationship is reasonably expected but, so far, it has not been demonstrated. Traditional Chinese medicine indicates that acupuncture can promote specific blood perfusion in specific body districts. Read More

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December 2018

Retinal Nerve Fiber Layer Thickness in a Multi-ethnic Normal Asian Population: the Singapore Epidemiology of Eye Diseases (SEED) Study.

Ophthalmology 2018 Dec 4. Epub 2018 Dec 4.

Singapore Eye Research Institute, Singapore National Eye Center, Singapore; Duke-NUS Medical School, Singapore; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore. Electronic address:

Purpose: To describe variations in retinal nerve fiber layer (RNFL) thickness based on spectral-domain OCT (SD-OCT) in a multi-ethnic Asian population.

Design: Population-based, cross-sectional study.

Participants: Ethnic Chinese, Malay and Indian adults, aged greater than 48 years without glaucoma, recruited from the Singapore Epidemiology of Eye Diseases (SEED) Study. Read More

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December 2018

Scheie's line as a first sign of pigment dispersion syndrome.

Arch Soc Esp Oftalmol 2018 Dec 4. Epub 2018 Dec 4.

Unidad de Neurooftalmología y Glaucoma, Servicio de Oftalmología, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Madrid, España.

A 50 year old woman was diagnosed with pigment dispersion syndrome (PDS) in the right eye and pigmentary glaucoma in the left eye in a routine medical examination. A line of pigment was observed in the vitreo-lenticular interface (Scheie's line) of the left eye and with an intraocular pressure of 26mmHg. The Scheie's line (SL) develops by the accumulation of detached iris pigment in PDS and accumulated in the ligament of Wieger that forms the vitreo-lenticular union. Read More

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December 2018

Non-GVHD ocular complications after hematopoietic cell transplantation: expert review from the Late Effects and Quality of Life Working Committee of the CIBMTR and Transplant Complications Working Party of the EBMT.

Biol Blood Marrow Transplant 2018 Dec 3. Epub 2018 Dec 3.

Department of Ophthalmology, Hospital Universitario Puerta de Hierro, Madrid, Spain.

Non-graft-versus-host disease (non-GVHD) ocular complications are generally uncommon after hematopoietic cell transplantation (HCT), but can cause prolonged morbidity affecting activities of daily living and quality of life. Here we provide an expert review of non-GVHD ocular complications in a collaboration between transplant physicians and ophthalmologists through the Late Effects and Quality of Life Working Committee of the Center for International Blood and Marrow Transplant Research and the Transplant Complications Working Party of the European Society of Blood and Marrow Transplantation. Complications discussed in this review include cataracts, glaucoma, ocular infections, ocular involvement with malignancy, ischemic microvascular retinopathy, central retinal vein occlusion, retinal hemorrhage, retinal detachment and ocular toxicities associated with medications. Read More

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December 2018
5 Reads

Outbreak of Epidemic Keratoconjunctivitis Caused by Human Adenovirus Type D53 in an Eye Care Clinic - Los Angeles County, 2017.

MMWR Morb Mortal Wkly Rep 2018 Dec 7;67(48):1347-1349. Epub 2018 Dec 7.

On June 22, 2017, the Los Angeles County Department of Public Health (LAC DPH) was notified of seven patients who were seen at an eye care clinic on June 8, 2017, and later developed symptoms of epidemic keratoconjunctivitis (EKC). EKC is a contagious, severe form of viral conjunctivitis that can cause pain and blurred vision for up to 4 weeks (1). LAC DPH conducted an investigation, which identified 17 patients with EKC, including 15 who had visited the optometry clinic and two who were household contacts of clinic patients. Read More

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December 2018
5 Reads

Follow-up and adherence to glaucoma care by newly diagnosed glaucoma patients in enugu, nigeria.

Ophthalmic Epidemiol 2018 Dec 6:1-7. Epub 2018 Dec 6.

a College of Medicine, Enugu State University of Technology(ESUT), Enugu State University of Science and Technology (ESUT) Teaching Hospital Parklane , The Eye Specialists Hospital (TESH) , Enugu , Nigeria.

Purpose: To determine uptake, adherence and influencing factors to follow-up care by newly diagnosed glaucoma patients from free eye screening exercise.

Methods: The study was a cross-sectional survey of newly diagnosed glaucoma patients during free eye screenings carried out in March and October, 2016 in Enugu, Nigeria. Data on participants were analyzed after a minimum of 6 months from the screening for uptake and adherence to follow-up care. Read More

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December 2018
1 Read

CYP1B1 Gene and Phenotypic Correlation in Patients from Northeastern Brazil with Primary Congenital Glaucoma.

J Glaucoma 2018 Dec 5. Epub 2018 Dec 5.

Hospital das Clínicas, Federal University of Pernambuco (HC - UFPE), Recife, Pernambuco, Brazil.

Purpose: To identify variants in the CYP1B1 gene in northeastern Brazilian patients with PCG and possible genotype-phenotype correlations.

Materials And Methods: This is a cross-sectional observational study of 17 non-related patients with PCG, performed at the Altino Ventura Foundation, Recife, Brazil, between December 2017 and February 2018. All patients underwent an examination, including gathering information from their medical records, slit lamp examination, fundoscopy, tonography, and measuring corneal diameter and thickness. Read More

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December 2018

[Combined XEN and Baerveldt implant-principles and management of complications].

Ophthalmologe 2018 Dec 5. Epub 2018 Dec 5.

Augenklinik und Poliklinik, Universitätsmedizin Mainz, Langenbeckstr. 1, 55116, Mainz, Deutschland.

The treatment of congenital glaucoma requires special expertise and often novel surgical approaches. The combined use of a XEN and a Baerveldt implant is an alternative to conventional tube implants and may be less harmful for long-term corneal endothelial damage. If this technique does not provide sufficient long-term control of intraorbital pressure (IOP), a direct implantation of the Baerveldt tube can be easily performed in a second intervention. Read More

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December 2018

Hypertensive crisis with massive retinal and choroidal infarction: A case update.

Am J Ophthalmol Case Rep 2019 Mar 10;13:22-24. Epub 2018 Nov 10.

Department of Ophthalmology, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Pl, New York, NY, USA.

Purpose: We report an update on a recently published case of uncontrolled hypertension secondary to immunoglobulin A (IgA) nephropathy resulting in massive bilateral retinal and choroidal infarction.

Observations: In our previous report, we presented a 30-year old female with end-stage renal disease who complained of painless vision loss after many missed hemodialysis. The patient was found to be in hypertensive crisis resulting in massive retinal and choroidal infarction with severe vision loss in both eyes. Read More

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March 2019
1 Read

Prospective pilot study comparing deep sclerectomy outcomes with a long-term and intense corticosteroid treatment versus a standard one.

BMJ Open Ophthalmol 2018 31;3(1):e000165. Epub 2018 Oct 31.

Glaucoma and Neuro-Ophthalmology Department, FISABIO Oftalmologia, Valencia, Spain.

Objective: To compare prospectively intraocular pressure (IOP) results after deep sclerectomy (DS) using a topical short-term corticosteroid treatment (STCT, 1  month) versus a topical long-term and intense corticosteroid treatment (LTCT, 6 months) in a two2  year-follow-up.

Methods: Patients with medically uncontrolled open angle glaucoma were prospectively recruited and underwent a DS.

Results: We operated 45 eyes of 45 patients, 22 in STCT group and 23 in LTCT group. Read More

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October 2018
1 Read

A Method to Measure the Rate of Glaucomatous Visual Field Change.

Transl Vis Sci Technol 2018 Nov 30;7(6):14. Epub 2018 Nov 30.

Jules Stein Eye Institute, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.

Purpose: To develop a method to measure the rate of glaucomatous visual field (VF) deterioration and to identify fast progressors.

Methods: Retrospective, longitudinal, observational study of 8486 eyes of 4610 glaucomatous patients with ≥6 VFs and ≥3 years of follow-up. A Glaucoma Rate Index (GRI) was calculated. Read More

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November 2018
2 Reads

Evaluation of RETICs Glaucoma Diagnostic Calculators in Preperimetric Glaucoma.

Transl Vis Sci Technol 2018 Nov 30;7(6):13. Epub 2018 Nov 30.

Institut Catalá de Retina, Universitat Internacional de Catalunya, Barcelona, Spain.

Purpose: To evaluate two glaucoma diagnostic calculators (GDC) in a group of eyes with preperimetric glaucoma (PPG).

Methods: All eyes ( = 265) included in this study had ocular hypertension with normal visual fields (VFs) on repeated VF tests. PPG was defined as progression in the Guided Progression Analysis software from Cirrus-optical coherence tomography (GPA-OCT). Read More

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November 2018

Lack of Association between Variant rs7916697 in and Primary Open Angle Glaucoma in a Saudi Cohort.

Genet Res Int 2018 1;2018:2148056. Epub 2018 Nov 1.

Glaucoma Research Chair, Department of Ophthalmology, College of Medicine, King Saud University, Riyadh, Saudi Arabia.

A case-control genetic association study was performed to investigate whether variant rs7916697 in (), which has been previously reported to be associated with optic disc parameters and primary open angle glaucoma (POAG) in different ethnic groups, is a risk factor for POAG or any of its clinical phenotypes in a Saudi cohort. Genotyping of rs7916697 (G>A) variant was performed in 186 unrelated POAG cases and 171 unrelated nonglaucomatous controls of Saudi origin using real-time Taq-Man® assay. Genotypic and allelic association with POAG and its related clinical indices were evaluated. Read More

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November 2018