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J Glaucoma 2021 Feb;30(2):192-194

James Cook University College of Medicine and Dentistry, Douglas.

Purpose: Minimally invasive glaucoma surgery (MIGS) is an emerging therapy for glaucoma. The Hydrus Microstent is a MIGS device that stents Schlemm's canal, thereby increasing aqueous drainage and lowering intraocular pressure (IOP). This article describes the use of the microstent in pseudophakic patients with medically refractory glaucoma, a patient population undocumented in the current literature. Read More

Eur J Ophthalmol 2021 May 2:11206721211014386. Epub 2021 May 2.

Department of Neurosciences, Biomedicine and Movement, University Eye Clinic, University of Verona, AOUI - Borgo Roma Hospital, Verona, Veneto, Italy.

Purpose: To evaluate the safety and efficacy of double compared to single intraluminal suture stenting in reducing early postoperative hypertensive spikes (HS) and hypotony after Baerveldt glaucoma implant surgery.

Methods: For this retrospective study, we reviewed the medical charts of 60 patients (60 eyes) who underwent Baerveldt drainage device surgery between 2017 and 2019. Two groups were formed according to whether a single suture stent was placed within the tube (5-0 polypropylene, 30 eyes, group 1) or a double suture (5-0 and 6-0 polypropylene, 30 eyes, group 2). Read More

Eur J Ophthalmol 2021 Apr 28:11206721211012869. Epub 2021 Apr 28.

The Sam Rothberg Glaucoma Center, Goldschleger Eye Institute, Sheba Medical Center, Ramat Gan, Israel, Affiliated to the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

Purpose: To summarize the surgical outcomes of Ahmed glaucoma valve (AGV) implantation with plate fixation with vicryl absorbable sutures or no plate suturing.

Methods: This study was a retrospective case series that included all glaucoma patients who underwent AGV implantation surgery with vicryl absorbable sutures for plate fixation or without plate fixation by a single surgeon between 2014 and 2019. We reviewed their medical records and retrieved clinical data on intra- and postoperative complications, best-corrected visual acuity, intraocular pressure (IOP), and number of IOP-lowering medications. Read More

Graefes Arch Clin Exp Ophthalmol 2021 Apr 26. Epub 2021 Apr 26.

Department of Ophthalmology, Cantonal Hospital of Lucerne, CH-6000, Lucerne 16, Switzerland.

Background: The two glaucoma drainage devices (GDD) Ahmed and Baerveldt tubes are most commonly used for the treatment of refractory glaucoma. We noticed a significant number of patients with postoperative motility disorders resulting in diplopia. We investigated the occurrence and patterns of postoperative motility disorders overall and between the two GDD tubes using the Hess Screen Test. Read More

J Glaucoma 2021 Apr 23. Epub 2021 Apr 23.

Department of Ophthalmology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.

Purpose: To evaluate the short-term outcomes of Ahmed Clear Path (ACP) valveless glaucoma drainage device in childhood glaucoma.

Methods: Retrospective chart review of all patients ≤16 years with childhood glaucoma who had ACP implantation at Boston Children's Hospital from December 2019 to June 2020 with at least 6 months follow-up period.

Results: The study included 7 eyes of 5 patients implanted by a single surgeon. Read More

J Glaucoma 2021 Apr 15. Epub 2021 Apr 15.

Department of Ophthalmology University of Florida, Gainesville, FL The Edward Via College of Osteopathic Medicine, Spartanburg, South Carolina.

Prcis: A comparison of 186 glaucoma patients with mixed diagnoses who underwent non-valved glaucoma drainage implant surgery showed similar long-term IOP, medication, and VA outcomes between those with prior failed trabeculectomy surgery versus those without.

Purpose: To evaluate whether prior failed trabeculectomy adversely affects the outcome of glaucoma tube surgery.

Patients And Methods: 186 eyes of 186 patients who underwent a non-valved glaucoma drainage implant (GDD) surgery by a single surgeon between 1996 and 2015 at a University practice were included. Read More

Ophthalmol Glaucoma 2021 Apr 6. Epub 2021 Apr 6.

Department of Ophthalmology, Massachusetts Eye and Ear, Boston, Massachusetts; Glaucoma Service, Massachusetts Eye and Ear, Boston, Massachusetts; Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts. Electronic address:

Purpose: Understanding trends and patterns in the use of minimally invasive glaucoma surgery (MIGS) and patient profiles undergoing each procedure is important given their relative expense and unknown long-term safety and effectiveness.

Design: Retrospective analysis.

Participants: Minimally invasive glaucoma surgeries and standard glaucoma surgeries recorded in the American Academy of Ophthalmology Intelligent Research in Sight (IRIS®) Registry. Read More

Ocul Immunol Inflamm 2021 Apr 8:1-3. Epub 2021 Apr 8.

Department of Uveitis, Moorfields Eye Hospital National Health Service Foundation Trust, London, UK.

: To report a case of exuberant anterior chamber inflammation post partial removal of supramid® stent.: Case report.: The sudden intraocular pressure drop induced by partial removal of ripcord suture from a glaucoma drainage device can result in blood-retinal and blood-aqueous barrier breakdown, inducing uveitis. Read More

Eur J Ophthalmol 2021 Mar 28:11206721211006643. Epub 2021 Mar 28.

Department of Ophthalmology, Mayo Clinic, Rochester, MN, USA.

Purpose: There is an increased risk for development of blepharoptosis after incisional glaucoma surgery. Data on safety and efficacy of ptosis repair in this group of patients in limited. The goal of this study is to evaluate outcomes and identify potential risk factors for failure of ptosis repair in eyes with history of incisional glaucoma surgery. Read More

Ophthalmol Glaucoma 2021 Mar-Apr;4(2):131-138. Epub 2020 May 22.

Department of Ophthalmology and Visual Science, Yale School of Medicine, New Haven, Connecticut. Electronic address:

Purpose: To examine the impact of the iStent (Glaukos) on the recent glaucoma surgical expenditure for Medicare Part B beneficiaries.

Design: Retrospective, observational, population-based analysis.

Participants: All applicable cases in the Centers for Medicare and Medicaid Services Part B Summary Data Files. Read More

Int Ophthalmol 2021 Mar 26. Epub 2021 Mar 26.

Research Department, Instituto de Ojos Oftalmosalud, Javier Prado Este 1142, San Isidro, Lima, Peru.

Introduction: To describe the outcomes of Baerveldt glaucoma implants implanted via a modified technique with regard to early intraocular pressure (IOP) reduction in cases of uncontrolled glaucoma.

Methods: The medical records of patients who had Baerveldt glaucoma implants of 350 or 250 mm implanted via a modified technique and were followed up for a period of at least 6 months were reviewed. The primary outcome measures were the mean IOP and number of glaucoma medications at each visit. Read More

J Glaucoma 2021 Apr;30(4):e190-e191

Cole Eye Institute, Cleveland Clinic Cleveland, OH.

Acta Ophthalmol 2021 Mar 23. Epub 2021 Mar 23.

Unit of Vitreoretinal Surgery, Department of Ophthalmology, Helsinki University Hospital, Research Programs, Individualized Drug Therapy, Helsinki University, Helsinki, Finland.

Purpose: To examine the association of systemic statin therapy and reoperation rate after glaucoma filtration surgery (GFS).

Methods: This is a population-based, historic cohort study of 2705 eyes undergoing GFS in Finland between July 2009 and December 2016. GFSs were identified from national administrative healthcare registers. Read More

Int Ophthalmol 2021 Mar 22. Epub 2021 Mar 22.

Cornea and External Diseases, Moorfields Eye Hospital, 162 City Road, London, EC1V 2PD, UK.

Background: The aim of this study was to evaluate the clinical outcomes of Descemet membrane endothelial keratoplasty (DMEK) in vitrectomized eyes.

Methods: A multi-surgeon, retrospective case series of previously vitrectomized eyes that underwent DMEK between 2013 and 2018 at Moorfields Eye Hospital. Patients' demographics, preoperative, intraoperative and postoperative data were collected. Read More

J Glaucoma 2021 Mar;30(3):e108-e113

Department of Ophthalmology, University Medical Center Schleswig-Holstein.

Precis: In eyes with intractable glaucoma, drainage devices provide long-term control of intraocular pressure also after penetrating keratoplasty (PK). There is a high incidence of corneal graft failure.

Purpose: To compare very long-term results of eyes with glaucoma drainage device (GDD) after PK. Read More

Int Ophthalmol 2021 Mar 21. Epub 2021 Mar 21.

Srimati Kanuri Santhamma Centre for Vitreo-Retinal Diseases, Kallam Anji Reddy Campus, L V Prasad Eye Institute, Banjara Hills, Hyderabad, India.

Purpose: To compare the disease characteristics and treatment outcomes of patients with neovascular glaucoma (NVG) presenting with visual acuity (VA) 6/60 or better in two different health systems.

Methods: Retrospective chart review of consecutive patients with NVG who presented between January 2016 to January 2018 in 5 tertiary-centres in India and one eye-specialist centre in London (UK) was performed. The baseline characteristics, treatment provisions, and visual outcomes in the India and UK cohorts were compared. Read More

Am J Ophthalmol 2021 Mar 15;227:173-181. Epub 2021 Mar 15.

Bascom Palmer Eye Institute, University of Miami School of Medicine, Miami, Florida, USA.

Purpose: To compare the outcomes of Aurolab aqueous drainage implant (AADI; Aurolab) placement and trabeculectomy with mitomycin C (MMC) in patients with glaucoma secondary to aniridia.

Design: Retrospective comparative interventional case series.

Methods: This study included patients with congenital aniridia who underwent AADI implantation or trabeculectomy with MMC. Read More

Eur J Ophthalmol 2021 Mar 18:11206721211004398. Epub 2021 Mar 18.

Royal Wolverhampton Hospitals NHS Trust, Wolverhampton, UK.

Purpose: Exposure of orbital implant post enucleation or evisceration remains one of the common complications irrespective of the type of implant used. Dermis fat graft and temporalis fascia have been used to repair the implant exposure in anophthalmic sockets. Tutoplast pericardium, gamma sterilised dehydrated human pericardium, has been used as a scleral patch graft for glaucoma drainage device exposure and scleral thinning post squint surgery. Read More

Ophthalmol Glaucoma 2021 Mar 8. Epub 2021 Mar 8.

Eye Surgery Associates, Melbourne, Australia.

Purpose: To evaluate the effect of primary needling at the time of ab interno gelatin microstent insertion on postoperative needling rates.

Design: Retrospective, interventional cohort study.

Participants: Eighty-six eyes of 74 patients with no prior incisional surgery. Read More

J Am Vet Med Assoc 2021 Mar;258(6):661-667

Objective: To develop a protocol for subconjunctival enucleation and orbital implant placement in standing horses and to document short- and long-term complications, cosmesis, and client satisfaction.

Animals: 20 horses with nonneoplastic ocular disease requiring enucleation.

Procedures: A standardized protocol of surgical suite cleaning, patient preparation, sedation, local nerve blocks, surgical procedure, and postoperative care was performed. Read More

J AAPOS 2021 Mar 3. Epub 2021 Mar 3.

Aravind Eye Hospital, Chennai.

J Glaucoma 2021 Mar 5. Epub 2021 Mar 5.

Mayo Clinic Alix School of Medicine, Mayo Clinic, Rochester, MN, USA Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic Medical Scientist Training Program, Rochester, MN, USA Department of Ophthalmology, Mayo Clinic, Rochester, MN, USA Department of Health Sciences Research, Mayo Clinic, Jacksonville, FL, USA.

Prcis: In this longitudinal study of patients with open-angle, pseudoexfoliative, or neovascular glaucoma receiving glaucoma drainage devices, post-tube cumulative rates of reoperation, corneal graft, and visually threatening complications increased beyond 5 years and were not significantly affected by glaucoma type.

Purpose: To study the need for additional glaucoma surgery and development of complications after first glaucoma drainage device (GDD) surgery in eyes with primary open-angle (OAG), pseudoexfoliative (PXE), or neovascular (NVG) glaucoma.

Patients And Methods: There were 306 eyes with OAG (n=185), PXE (n=60), or NVG (n=61) glaucoma who received a first GDD between 1996 and 2017. Read More

Eye (Lond) 2021 Mar 5. Epub 2021 Mar 5.

Department of Ophthalmology, University of Florida College of Medicine, Gainesville, FL, USA.

Glaucoma drainage device (GDD)-related endophthalmitis is a devastating complication of device implantation. There are no guidelines in the literature to assist clinicians in deciding if the GDD should be explanted or if patients require pars plana vitrectomy (PPV). This study compares the outcomes of GDD explantation with device retention and also independently compares the outcomes of PPV versus intravitreal antibiotics alone in patients with GDD-related endophthalmitis. Read More

J Clin Med 2021 Feb 17;10(4). Epub 2021 Feb 17.

Department of Ophthalmology, Tri-Service General Hospital, National Defense Medical Center, Taipei 114, Taiwan.

For chronic angle-closure glaucoma (ACG), Ahmed glaucoma valve (AGV) is a useful drainage device for intraocular pressure (IOP) control but there are few reports discussing the outcomes of small size AGV in adult patients. This retrospective study involved 43 Asian adult patients (43 eyes) with chronic ACG. All patients had undergone small size AGV insertion and were divided into anterior chamber (AC) group and posterior chamber (PC) group. Read More

BMC Ophthalmol 2021 Feb 25;21(1):106. Epub 2021 Feb 25.

Massachusetts Eye and Ear, Department of Ophthalmology, Harvard Medical School, Boston, MA, USA.

Purpose: The purpose of this study is to report the safety and efficacy of pars plana glaucoma drainage devices with pars plana vitrectomy using one of the vitrectomy sclerotomy sites for tube placement in patients with refractory glaucoma.

Methods: Retrospective case series of 28 eyes of 28 patients who underwent combined pars plana glaucoma drainage device and pars plana vitrectomy between November 2016 and September 2019 at Massachusetts Eye and Ear. Main outcome measures were intraocular pressure (IOP), glaucoma medication burden, best corrected visual acuity, and complications. Read More

Acta Ophthalmol 2021 Feb 24. Epub 2021 Feb 24.

Glaucoma Department, The Rotterdam Eye Hospital, Rotterdam, The Netherlands.

Purpose: To determine whether the postoperative corneal endothelial cell density (ECD) differs between glaucoma patients who underwent Baerveldt implant (BGI) surgery and patients who underwent a trabeculectomy (TE) over 5 years ago.

Methods: Cross-sectional, observational study including 34 patients who underwent TE and 36 patients who underwent BGI surgery 5-11 years ago, as part of a randomized clinical trial. None of the patients had a history of intraocular surgery prior to their glaucoma surgery. Read More

BMC Ophthalmol 2021 Feb 23;21(1):99. Epub 2021 Feb 23.

Glaucoma Division, King Khaled Eye Specialist Hospital Riyadh, Al Arubah Branch Rd, Riyadh, 11462, Saudi Arabia.

Background: The use of a tissue patch graft is common practice with a glaucoma drainage device (GDD). Patch grafts can be visible in the palpebral fissure and may be cosmetically displeasing for some patients. The aim of this study was to report the cosmetic satisfaction of pericardial, scleral, and corneal patch grafts related to superior GDD surgery. Read More

Vet Ophthalmol 2021 Mar 20;24 Suppl 1:109-115. Epub 2021 Feb 20.

Small Animal Specialist Hospital, Sydney, NSW, Australia.

Objective: To report outcomes and follow-up of Baerveldt implant surgery in dogs with primary closed-angle glaucoma (PCAG).

Materials And Methods: Record review of client-owned dogs with PCAG that underwent Baerveldt implant surgery during a 6-year period. Postoperative intraocular pressure (IOP), vision and daily number of anti-glaucoma drops at fixed time points (3, 12, and 24 months) were compared with preoperative values; complications were recorded. Read More

Clin Ophthalmol 2021 9;15:461-472. Epub 2021 Feb 9.

Department of Ophthalmology, Innova Ocular ICO-Barcelona, Barcelona, Spain.

Purpose: To investigate risk factors associated with success and failure in double-plate tube surgery.

Methods: This retrospective case-series observational study included 243 consecutive eyes that underwent anterior-segment double-plate tube surgery from 1990 to 2015. Evaluation of the efficacy of the device was based on the final intraocular pressure (IOP) and the need for anti-glaucoma medication. Read More

J Glaucoma 2021 Apr;30(4):e190

Education and Research, Glaucoma Services, CL Gupta Eye Institute, Moradabad, India.