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Ophthalmology 2022 Jul;129(7):802

Department of Ophthalmology & Visual Sciences, University of Chicago, Chicago, Illinois.

BMC Ophthalmol 2022 Jun 20;22(1):270. Epub 2022 Jun 20.

Department of Ophthalmology, School of Medicine, Kyungpook National University, 680 gukchaebosang-ro, Jung-gu, Daegu, 41944, South Korea.

Background: We evaluated the long-term efficacy and surgical outcomes of Ahmed glaucoma valve (AGV) implantation in patients with refractory glaucoma by glaucoma type.

Methods: In total, 135 eyes of 135 patients diagnosed with refractory glaucoma and underwent AGV implantation between 2002 and 2018 were reviewed retrospectively. The best-corrected visual acuity (BCVA), intraocular pressure (IOP), and number of antiglaucoma medications were investigated at baseline and follow-up. Read More

BMJ Open 2022 Jun 15;12(6):e051496. Epub 2022 Jun 15.

Department of Ophthalmology, Zhejiang University School of Medicine First Affiliated Hospital, Hangzhou, Zhejiang, China

Objectives: To compare the efficacy and safety of two Schlemm's canal-based microinvasive glaucoma surgery (MIGS) devices, the Hydrus Microstent and the iStent Trabecular Bypass combined with phacoemulsification for treatment of open-angle glaucoma.

Design: Systematic review and network meta-analysis.

Methods: Literature searches were conducted on PubMed, Web of Science, Cochrane Library and ClinicalTrials. Read More

Zhongguo Yi Liao Qi Xie Za Zhi 2022 May;46(3):292-295

Ophthalmology Department, Tongji Hospital of Tongji Uiversity, Shanghai, 200065.

The treatment of refractory Glaucoma is a difficult problem in clinical ophthalmology. For refractory glaucoma patients with hyphema, shallow anterior chamber, anterior conglutination of peripheral chamber angle, corneal endothelium dystrophy or decompensated, at present, there is no effective treatment. In order to solve this problem, a new type posterior integral glaucoma valve with IOP control device was designed using medical titanium alloy, and the valve model was established by Abaqus software, and the stiffness and preload of the valve were analyzed by finite element method. Read More

J Glaucoma 2022 Jun 3. Epub 2022 Jun 3.

Department of Ophthalmology, Cantonal Hospital of Lucerne, CH-6000 Lucerne-16, Switzerland.

We report a new surgical technique for controlling flow with a PreserFlo® MicroShunt, in patients with late postoperative hypotony, following a Baerveldt glaucoma drainage device implantation. We present two cases with late postoperative hypotony after Baerveldt-shunt implantations. In both cases, the outflow resistance of the Baerveldt tube was modulated by the insertion of a PreserFlo® MicroShunt into the lumen of the Baerveldt tube. Read More

Semin Ophthalmol 2022 Jun 3:1-13. Epub 2022 Jun 3.

VST Centre for Glaucoma Care, LV Prasad Eye Institute, Hyderabad, India.

Purpose: The purpose of this review is to place together all the knowledge available on aurolab aqueous drainage implant (AADI) in one place for the benefit of all glaucoma specialists who are interested in low-cost implants in developing world with desired results.

Methods: A comprehensive literature search was done on AADI and its use in glaucoma management. 35 results were obtained from the literature search. Read More

Oxid Med Cell Longev 2022 23;2022:3050007. Epub 2022 May 23.

Department of Ophthalmology, Xianyang First People's Hospital, Baoji, 712099 Shaanxi Province, China.

Purpose: To observe and compare the efficacy of modified trabeculectomy (TE), Ahmed drainage valve implantation (AGV), and EX-PRESS glaucoma shunt for refractory glaucoma (RG).

Methods: The study population of this retrospective study comprised 73 patients (76 eyes) who were suffering from RG and treated with modified TE, AGV, and EX-PRESS glaucoma shunt in our hospital from October 2012 to October 2020. The number of cases who underwent modified TE, AVG, and EX-PRESS glaucoma shunt was 36 (38 eyes). Read More

Indian J Ophthalmol 2022 Jun;70(6):2182-2183

Department of Glaucoma, Centre for Sight, Road No 2 Banjara Hills, Hyderabad, Telangana, India.

Indian J Ophthalmol 2022 Jun;70(6):2180-2182

Department of Ophthalmology, Queens Medical Centre, Lenton, Nottingham, United Kingdom.

We present a case of advanced glaucoma with previously failed trabeculectomy who underwent a Baerveldt tube (BVT) insertion, with initial success. However, 9 months post BVT insertion he developed profound clinically significant hypotony. Two attempts at controlling this with suture exchange led to episodes of significant ocular hypertension, followed by hypotony each time. Read More

BMC Ophthalmol 2022 May 25;22(1):235. Epub 2022 May 25.

Division of Ophthalmology, Ann & Robert H. Lurie Children's Hospital of Chicago, 225 E. Chicago Ave, Chicago, IL, 60611, USA.

Background: Evaluate outcomes and identify prognostic factors in congenital aniridia.

Methods: Retrospective interventional case series of patients with congenital aniridia treated between 2012-2020. Ocular examination and surgical details were collected. Read More

BMJ Open 2022 05 24;12(5):e051794. Epub 2022 May 24.

Shenzhen Eye Institute, Shenzhen Eye Hospital, Shenzhen, Guangdong Province, China

Objective: To compare the effectiveness and safety of the six interventions for neovascular glaucoma.

Design: A systematic review and network meta-analysis.

Methods: Randomised controlled trials and cohort studies which compared the six interventions in neovascular glaucoma were identified using the following databases searched up to 1 September 2020: PubMed, Cochrane Library, Embase and Web of Science. Read More

Clin Ophthalmol 2022 13;16:1487-1496. Epub 2022 May 13.

Glaucoma Division, King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia.

Purpose: We describe the technique of trimming the 350 mm AADI glaucoma shunt plate and report preliminary results that test the hypothesis that the IOP-lowering efficacy of the trimmed AADI glaucoma shunt is comparable to the Baerveldt 250 mm glaucoma drainage implant with a comparable safety profile to the standard AADI implant.

Methods: Consecutive patients who had received the modified trimmed-plate AADI, standard AADI and Baerveldt 250 mm were included in the study. This included patients with refractory or primary or secondary glaucoma of all ages and eyes with and without previous glaucoma surgery. Read More

Am J Ophthalmol Case Rep 2022 Jun 4;26:101569. Epub 2022 May 4.

Glaucoma Associates of Texas, 10740 N. Central Expressway, Suite 300, Dallas, TX, 75231, USA.

Purpose: To describe the iSTAT (Intraluminal Suture Transfixed and Titratable) technique, an improvement on prior tube occlusion methods, allowing for variable flow.

Observations: A 76-year-old woman who underwent an uncomplicated glaucoma drainage device (GDD) placement for uncontrolled mixed mechanism glaucoma presented with hypotony 4 years post-operatively. The iSTAT technique was performed to adjust the flow in the GDD tube: a 4-0 polypropylene suture tip was blunted with a low-temperature cautery, creating a bulbed end that would occlude the tube. Read More

Arq Bras Oftalmol 2022 May 9. Epub 2022 May 9.

Ophthal Hospital Especializado Ltda, São Paulo, SP, Brasil.

This is a case report involving a 56-year-old male patient with a history of pars plana vitrectomy due to a rhegmatogenous retinal detachment in the right eye that resulted in the implantation of a drainage device after the patient developed secondary glaucoma. Two years after the device's implantation, the patient was referred to our care as his visual acuity had decreased to 20/200 (1.00 LogMAR). Read More

Korean J Ophthalmol 2022 06 6;36(3):282-284. Epub 2022 May 6.

Department of Ophthalmology, Hanyang University Seoul Hospital, Seoul, Korea.

Graefes Arch Clin Exp Ophthalmol 2022 May 6. Epub 2022 May 6.

Birmingham and Midland Eye Centre, City Hospital, Sandwell and West Birmingham Hospitals NHS Trust, Dudley Road, Birmingham, B18 7QH, UK.

Purpose: Several studies have demonstrated decompensation of intraocular pressure (IOP) control following phacoemulsification in eyes with a functioning trabeculectomy. Limited evidence base suggests that this effect is minimal in eyes with functioning glaucoma drainage devices (GDD). The aim of this study was to report on glaucoma control after phacoemulsification in eyes with a functioning GDD compared to eyes with a functioning trabeculectomy. Read More

Indian J Ophthalmol 2022 05;70(5):1842-1843

Vitreo Retina Department, Disha Eye Hospitals Pvt Ltd, Kolkata, West Bengal, India.

Indian J Ophthalmol 2022 05;70(5):1812-1814

Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India.

The presence of emulsified silicone oil in the eye can lead to many complications, glaucoma being one of the most common. Adequate IOP control is difficult to achieve with medical management alone; surgical intervention is often required. Glaucoma drainage device implantation is often the preferred line of surgical intervention in such cases due to trabeculectomy failure from emulsified silicone oil droplets and associated conjunctival scarring. Read More

Indian J Ophthalmol 2022 05;70(5):1443-1445

Department of Glaucoma, Centre for Sight, Hyderabad, Telangana, India.

Transl Vis Sci Technol 2022 04;11(4):24

Department of Ophthalmology, Mayo Clinic, 200 First Street SW, Rochester, MN, USA.

Purpose: To improve outcomes for subretinal implantation surgery in pigs.

Methods: Analysis of variables affecting the success of subretinal implantation surgery was performed on videos of 37 surgeries. Ex vivo experiments were conducted to measure intraocular pressure (IOP) and test various prototyped implanters for effectiveness at maintaining IOP. Read More

Klin Monbl Augenheilkd 2022 Apr 26;239(4):429-434. Epub 2022 Apr 26.

Department of Ophthalmology, Universitätsspital Basel, Basel, Switzerland.

Purpose: Several new implant devices have recently been introduced to glaucoma surgery using various techniques for reducing intraocular pressure (IOP). Two implants introduced during the past couple of years, XEN45 and PreserFlo Microshunt, are both designed to control subconjunctival filtration. There are two Swiss multicenter studies that collected the data retrospectively to analyze the efficacy and safety of these two devices separately. Read More

Int Ophthalmol 2022 Apr 20. Epub 2022 Apr 20.

Aravind Eye Hospital and Post Graduate Institute of Ophthalmology, Madurai, Tamil Nadu, 625020, India.

Purpose: To investigate the efficacy and safety of non-valved Aurolab aqueous drainage implant (AADI) surgery combined with phacoemulsification in eyes with refractory glaucoma and coexistent cataract.

Methods: Included patients of 18 years or older who underwent combined AADI-Phacoemulsification from June 2015 to January 2017 with at least 12 months of consecutive follow-up. The best-corrected visual acuity, intraocular pressure (IOP), and the number of IOP-lowering medications were recorded at baseline, 2 weeks, 1, 3, 6, 12, 18, and 24 months. Read More

Arq Bras Oftalmol 2022 Mar 7. Epub 2022 Mar 7.

Department of Ophthalmology, Dokuz Eylul University, Izmir, Turkey.

Purpose: To describe the frequency, clinical characteristics, complications, and management of glaucoma in eyes that underwent keratoprosthesis implantation.

Methods: Patients who underwent keratoprosthesis surgery between June 2010 and January 2020 were retrospectively evaluated for glaucoma association and prognoses.

Results: Among 17 patients who underwent keratoprosthesis surgery, 9 (52. Read More

Int Med Case Rep J 2022 5;15:141-155. Epub 2022 Apr 5.

Department of Ophthalmology, University of Calabar Teaching Hospital, Calabar, Nigeria.

Purpose: To report incidence, clinical presentation, and treatment outcome of full-thickness macular hole (FTMHs) diagnosed post pars plana vitrectomy.

Methods: We retrospectively reviewed the demographics, best-corrected visual acuity (BCVA), indication for the primary vitrectomy, time to diagnose the secondary FTMH, optical coherence tomographic (OCT) appearance, and treatment outcome of FTMHs, occurring after vitrectomy performed between January 2019 and December 2020.

Results: Six of 523 vitrectomized eyes developed FTMHs, an incidence of 1. Read More

Transl Vis Sci Technol 2022 04;11(4)

Department of Ophthalmology, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan.

Purpose: To evaluate tissue reactivity to, and the stability of, glaucoma drainage device materials placed under rabbit conjunctiva in vivo.

Methods: Disks (diameter, 3 mm; thickness, ∼0.3 mm) fabricated from poly(styrene-block-isobutylene-block-styrene) (SIBS), silicone, stainless-steel, or glutaraldehyde cross-linked collagen (GACLC) were inserted under rabbit conjunctiva. Read More

Oman J Ophthalmol 2022 Jan-Apr;15(1):31-35. Epub 2022 Mar 2.

Glaucoma Research Center, Wills Eye Hospital, Philadelphia, Pennsylvania, USA.

Objective: To compare the surgical outcomes and early postoperative complications of Ahmed glaucoma valve (AGV) implantation performed by residents with those performed by attending physicians.

Methods: This is a retrospective, case-control study. Data were gathered from chart reviews of consecutive cases of AGV model FP7 implantation between January 2014 and July 2017. Read More

Am J Ophthalmol 2022 Apr 2;240:302-320. Epub 2022 Apr 2.

From Massachusetts Eye and Ear, Department of Ophthalmology, Harvard Medical School (N.E.H, E.K.C, S.S, S.G, T.E, A.C.L, J.W.M, D.S-D.V). Electronic address:

Purpose: To elucidate risk factors for revision or removal of glaucoma drainage devices (GDD) in glaucoma patients in the United States.

Design: Retrospective cohort study.

Methods: IRIS Registry (Intelligent Research in Sight) patients who underwent GDD insertion between January 1, 2013 and December 31, 2018 were included. Read More

BMC Ophthalmol 2022 Apr 1;22(1):149. Epub 2022 Apr 1.

Department of Ophthalmology, Northwestern University Feinberg School of Medicine, 645 N. Michigan Ave, #440, Chicago, Illinois, 60611, USA.

Background: This study aims to describe outcomes of posteriorly-placed glaucoma drainage devices (GDD) with concurrent endoscopic vitrectomy in pediatric patients with glaucoma and corneal opacification.

Methods: This retrospective case series identified patients under 18 years of age who underwent posteriorly-placed GDD implantation with concurrent endoscopic vitrectomy between 2012 and 2021. Data collected included ocular diagnoses, prior intraocular surgeries, type and position of GDD, surgical complications, and additional surgeries. Read More

Am J Ophthalmol 2022 Mar 28;241:1-8. Epub 2022 Mar 28.

Division of Ophthalmology, Ann & Robert H. Lurie Children's Hospital of Chicago (B.L.B.); Department of Ophthalmology, Northwestern University Feinberg School of Medicine (B.L.B.), Chicago, Illinois, USA. Electronic address:

Purpose: To determine the visual outcomes and effectiveness of glaucoma surgeries in congenital ectropion uvea.

Design: Retrospective interventional case series.

Methods: Surgeries and examination findings were collected on 11 eyes of 8 patients with congenital ectropion uvea at 2 academic sites from 2001 to 2021. Read More

Am J Ophthalmol 2022 Jul 26;239:223-229. Epub 2022 Mar 26.

From the Department of Ophthalmology and Vision Science, University of California, Davis, Sacramento, California, USA. Electronic address:

Purpose: In patients with refractory childhood glaucoma, treatment options include trabeculectomy or large glaucoma drainage devices (GDDs) with attendant short- and long-term risks. A novel polymer-based microshunt is under review by the US Food and Drug Administration (FDA) for use in adults. The device is attractive for children given the long-term stability of the polymer and the small conjunctival incision required for implantation. Read More