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BMC Ophthalmol 2022 May 25;22(1):235. Epub 2022 May 25.

Division of Ophthalmology, Ann & Robert H. Lurie Children's Hospital of Chicago, 225 E. Chicago Ave, Chicago, IL, 60611, USA.

Background: Evaluate outcomes and identify prognostic factors in congenital aniridia.

Methods: Retrospective interventional case series of patients with congenital aniridia treated between 2012-2020. Ocular examination and surgical details were collected. Read More

Clin Ophthalmol 2022 26;16:1261-1279. Epub 2022 Apr 26.

Department of Ophthalmology, Shimane University Faculty of Medicine, Izumo City, Shimane, 693-8501, Japan.

Current therapeutic approaches for glaucoma aim to reduce intraocular pressure (IOP), which is the only available and reliable strategy proven to control the risk of disease development and progression. Omidenepag isopropyl (OMDI) is a novel topical ocular hypotensive agent that was launched onto the market for the treatment of glaucoma and ocular hypertension (OHT). After topical instillation and during corneal penetration, OMDI is converted into the active metabolite omidenepag (OMD), which behaves as a non-prostaglandin, selective E-prostanoid subtype 2 (EP2) receptor agonist. Read More

Cornea 2022 Mar 31. Epub 2022 Mar 31.

Price Vision Group, Indianapolis, IN.

Purpose: The purpose of this study was to evaluate 15-year outcomes of Descemet stripping endothelial keratoplasty (DSEK).

Methods: We retrospectively reviewed an initial, consecutive series of 350 DSEK cases in 290 patients (mean age 69 years), performed between December 2003 and December 2005 for Fuchs dystrophy (86%), pseudophakic/aphakic bullous keratopathy (10%), or failed penetrating keratoplasty (4%). Outcomes included best spectacle-corrected visual acuity (BSCVA), endothelial cell density (ECD), and graft failure (defined as regraft for any reason or persistent loss of stromal clarity). Read More

Indian J Ophthalmol 2022 Apr;70(4):1239-1245

Department of Glaucoma, Dr. Shroff's Charity Eye Hospital, New Delhi, India.

Purpose: To carry out a prospective study to analyze the incidence and various preoperative, intraoperative, and postoperative risk factors for the development of PPKG.

Methods: A total of 207 patients were analyzed prospectively, who were operated for penetrating keratoplasty (PK) in a tertiary eye care hospital between the time period of August 1, 2017 and February 28, 2018 and were followed up till the sixth month. Each patient was analyzed at every visit to determine the factors responsible for post-keratoplasty glaucoma. Read More

JAMA Ophthalmol 2022 03;140(3):269-276

Department of Ophthalmology and Vision Science, University of Arizona, Tucson.

Importance: Cataract is an important cause of visual impairment in children. Data from a large pediatric cataract surgery registry can provide real-world estimates of visual outcomes and the 5-year cumulative incidence of adverse events.

Objective: To assess visual acuity (VA), incidence of complications and additional eye operations, and refractive error outcomes 5 years after pediatric lensectomy among children younger than 13 years. Read More

Asia Pac J Ophthalmol (Phila) 2021 Nov 24;10(6):553-563. Epub 2021 Nov 24.

Department of Ophthalmology, University of Florida, Gainesville, FL, US.

Purpose: To report outcomes of glaucoma drainage device (GDD) surgery based on primary or secondary glaucoma diagnosis and lens status.

Design: Single-center, retrospective, consecutive cohort study.

Methods: University of Florida patients aged 18 to 93 years who underwent nonvalved GDD surgery between 1996 and 2015 with a minimum of 1-year follow-up were examined. Read More

Clin Ophthalmol 2021 18;15:4189-4199. Epub 2021 Oct 18.

Excellence Center of Cornea and Limbal Stem Cell Transplantation, Department of Ophthalmology, King Chulalongkorn Memorial Hospital, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.

Purpose: To evaluate long-term survival outcomes and determine the prognostic factors of corneal transplantation performed at a tertiary referral hospital in Thailand.

Design: A 15-year retrospective cohort study.

Materials And Methods: One corneal graft per patient was selected; graft failure was defined as graft opacity due to recurrent disease or endothelial cell dysfunction. Read More

Int Ophthalmol 2022 Feb 11;42(2):541-547. Epub 2021 Oct 11.

Eye Research Center, Farabi Eye Hospital, Tehran University of Medical Sciences, South Karegar avenue, Qazvin square, Tehran, Iran.

Purpose: To present the 5-year outcomes obtained from the infantile cataract surgery in pediatric population.

Methods: Medical records of all patients with unilateral or bilateral infantile cataract who had undergone lensectomy and anterior vitrectomy with or without intraocular lens implantation before 10 years of age were evaluated. Patients with any history of ocular trauma, retinal or corneal dystrophy, ocular or orbital surgery, retinopathy of prematurity, raised intraocular pressure at the time of diagnosis, or incomplete follow-up sessions were excluded from the research. Read More

Int Ophthalmol 2022 Mar 10;42(3):969-980. Epub 2021 Oct 10.

Department of Ophthalmology, Dokuz Eylul University School of Medicine, 35340, Izmir, Turkey.

Purpose: To evaluate the clinical outcomes of pseudophakic/aphakic eyes with uncontrolled glaucoma that underwent Ahmed glaucoma valve implantation with the tube placement in the ciliary sulcus.

Methods: Medical records of the patients who underwent Ahmed glaucoma valve implantation through the ciliary sulcus, between December 2017 and June 2019, were reviewed retrospectively. Patients' age, gender, glaucoma diagnosis, visual acuity, intraocular pressure levels, and complications were recorded. Read More

J Fr Ophtalmol 2021 Nov 27;44(9):1387-1395. Epub 2021 Jul 27.

Service 3, Quinze-Vingts National Ophthalmology Hospital, INSERM-DGOS CIC 1423, IHU Foresight, 28, Rue de Charenton, 75012 Paris, France; Sorbonne Université, INSERM, CNRS, Institut de la Vision, Paris, France; Department of Ophthalmology, Ambroise Paré Hospital, AP-HP, Université de Versailles Saint-Quentin en Yvelines, Boulogne-Billancourt, France.

Purpose: To evaluate a customized silicone flexible artificial iris in cases of aniridia or iris deficiencies.

Setting: Centre Hospitalier National d'Ophtalmologie, Hôpital des Quinze-Vingts, Paris, France.

Design: Retrospective case series investigating cosmetic result, photophobia, endothelial cell density and intraocular pressure. Read More

Nepal J Ophthalmol 2021 Jan;13(25):98-103

Gandaki Medical College Teaching Hospital and Research Centre, Pokhara, Nepal.

Background: To determine the clinical profile and causes of various types of secondary glaucoma.

Materials And Methods: This was a hospital-based cross-sectional study conducted in a tertiary eye hospital of eastern Nepal from 1st June to 30th November, 2017. Patients who met the criteria for secondary glaucoma underwent detailed ophthalmic examination. Read More

PLoS One 2021 21;16(4):e0249945. Epub 2021 Apr 21.

Glaucoma Services, LV Prasad Eye Institute, Bhubaneswar, India.

Purpose: To evaluate changes in central corneal thickness (CCT) following vitrectomy.

Methods: All consecutive old and new patients referred to glaucoma services for possible secondary glaucoma after vitrectomy and who had undergone corneal pachymetry between July 2013 to June 2020, were included. The eye that developed elevated intraocular pressure (IOP) and was diagnosed clinically as glaucoma after vitrectomy, was labelled as the "affected" eye. Read More

Oman J Ophthalmol 2020 Sep-Dec;13(3):173-175. Epub 2020 Nov 2.

Cornea Department, Arasan Eye Hospital, Erode, Tamil Nadu, India.

Silicone oil (SO) is a commonly used tamponading agent in retinal detachment surgeries. Inadvertent anterior migration of SO and complete anterior chamber (AC) oil fill in an aphakic or pseudophakic eye is occasionally encountered. This can cause secondary glaucoma with very high intraocular pressure and pain. Read More

Ann Transl Med 2020 Nov;8(22):1545

INSERM UMRS 1138, Team 17, From Physiopathology of Ocular Diseases to Clinical Development, Université Sorbonne Paris Cité, Centre de Recherche des Cordeliers, Paris, France.

Congenital cataract is a rare eye disease, one of the leading treatable causes of low vision in children worldwide. Hereditary cataracts can be divided in syndromic and non-syndromic cataracts. Early diagnosis in congenital cataracts is key to reach good visual function. Read More

Cornea 2020 Nov;39(11):1359-1365

School of Optometry and Ophthalmology, Wenzhou Medical University, Wenzhou, Zhejiang, China; and.

Purpose: To evaluate changes in central corneal thickness (CCT) and intraocular pressure (IOP) in children after surgery for congenital cataracts and to investigate the association between CCT and IOP.

Methods: For this prospective observational cohort study, we recruited patients undergoing surgery for unilateral or bilateral congenital cataracts. CCT and IOP were measured before surgery and 1, 3, 6, 12, and 24 months after surgery. Read More

Eye (Lond) 2021 Jun 21;35(6):1637-1643. Epub 2020 Aug 21.

Department of Ophthalmology, Kasr Al-Ainy Hospitals, Cairo University, Cairo, Egypt.

Purpose: The management of glaucoma following cataract surgery (GFCS) in children is challenging. This study looks at the results of two-site trabeculotomy in paediatric aphakic/pseudophakic glaucoma, 1-year post operatively.

Methods: This prospective, institutional study was performed on 33 eyes with GFCS in patients aged ≤14 years. Read More

J Glaucoma 2020 10;29(10):e116-e119

Birmingham and Midland Eye Centre, Sandwell and West Birmingham Hospitals NHS Trust, Birmingham.

Gonioscopy-assisted transluminal trabeculotomy (GATT) is a minimally invasive ab interno procedure, performed with guidance of an illuminating microcatheter device (iTrack). The pathophysiology of raised intraocular pressure (IOP) in uveitic glaucoma is commonly due to increased resistance at the trabecular meshwork-Schlemm canal. By removing this resistance, GATT can potentially control the IOP. Read More

Graefes Arch Clin Exp Ophthalmol 2021 Jan 17;259(1):213-221. Epub 2020 Aug 17.

Department of Ophthalmology, Advanced Eye Centre, Post Graduate Institute of Medical Education and Research, Chandigarh, 160012, India.

Purpose: To study the complications and surgical outcomes of cataract surgery in patients of persistent fetal vasculature (PFV) with cataract.

Methods: In this prospective study, phacoaspiration with/without intraocular lens implantation (IOL) was done in 20 children (mean age 14.2 months) with unilateral cataract with anterior (n = 6) or combined (n = 14) PFV. Read More

Medwave 2020 Jul 22;20(6):e7965. Epub 2020 Jul 22.

Proyecto Epistemonikos, Santiago, Chile; Departamento de Oftalmología, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile. Email: Address: Centro Evidencia UC, Pontificia Universidad Católica de Chile, Diagonal Paraguay 476, Santiago, Chile.

Introduction: Cataract surgery increases the risk for rhegmatogenous retinal detachment. Pars plana vitrectomy and scleral buckling are two surgical procedures used for its repair. The combination of both techniques had been proposed for rhegmatogenous retinal detachment in patients with previous cataract surgery (pseudophakic or aphakic), but its effectiveness remains unclear. Read More

Br J Ophthalmol 2020 08 12;104(8):1040-1044. Epub 2020 Jun 12.

University of Ottawa, Faculty of Medicine, Ottawa, Ontario, Canada

Background: Of the side effects of prostaglandin analogues (PGAs), uveitis and cystoid macular oedema (CME) have significant potential for vision loss based on postmarket reports. Caution has been advised due to concerns of macular oedema and uveitis. In this report, we researched and summarised the original data suggesting these effects and determined their incidence. Read More

Med J Armed Forces India 2020 Apr 15;76(2):166-171. Epub 2019 Apr 15.

Senior Advisor (Ophthalmology), Command Hospital (Air Force), Bengaluru, India.

Background: Endothelial keratoplasties have become the surgical procedure of choice over full thickness penetrating keratoplasty for corneal decompensation because of endothelial dysfunction.

Methods: A retrospective data review was performed from February 2016 to April 2017 for all the patients who underwent endothelial keratoplasty in a tertiary care center for Indian Armed Forces.

Results: A total of 161 corneal transplants were performed; endothelial keratoplasties accounted for 34 (21. Read More

Eur J Ophthalmol 2020 Sep 14;30(5):1179-1184. Epub 2020 Apr 14.

Department of Ophthalmology, Kasr Al Ainy Hospital, Cairo University, Giza, Egypt.

Purpose: To evaluate the safety and efficacy of a novel approach to implant Ex-Press mini shunt via the pars plana under a scleral flap in pseudophakic or aphakic, vitrectomized patients with secondary refractory glaucoma.

Methods: A prospective interventional case series of three patients with secondary glaucoma after pars plana vitrectomy. Intraocular pressure was not controlled by silicone oil removal, if the patient was siliconized, nor the maximum medical treatment. Read More

Ophthalmology 2020 04 9;127(4):501-510. Epub 2019 Nov 9.

Department of Ophthalmology, Emory University School of Medicine, Atlanta, Georgia; Departments of Ophthalmology and Pediatrics, Stanford University School of Medicine, Palo Alto, California.

Purpose: To evaluate outcomes of bilateral cataract surgery in infants 1 to 7 months of age performed by Infant Aphakia Treatment Study (IATS) investigators during IATS recruitment and to compare them with IATS unilateral outcomes.

Design: Retrospective case series review at 10 IATS sites.

Participants: The Toddler Aphakia and Pseudophakia Study (TAPS) is a registry of children treated by surgeons who participated in the IATS. Read More

JAMA Ophthalmol 2020 01;138(1):71-75

Flaum Eye Institute, University of Rochester Medical Center, Rochester, New York.

Importance: Glaucoma can occur following cataract removal in children, and determining the risk for and factors associated with glaucoma and glaucoma suspect in a large cohort of children after lensectomy can guide clinical practice.

Objective: To estimate the incidence of glaucoma and glaucoma suspect and describe its management in the first year following lensectomy in children before 13 years of age.

Design, Setting, And Participants: A multicenter clinical research registry containing data for 1361 eyes of 994 children who underwent unilateral or bilateral lensectomy between June 2012 and July 2015 at 1 of 61 sites in the United States (n = 57), Canada (n = 3), and the United Kingdom (n = 1). Read More

Am J Ophthalmol 2020 02 10;210:158-166. Epub 2019 Oct 10.

Department of Ophthalmology, Medical Faculty Mannheim of the Ruprecht-Karls-University of Heidelberg, Mannheim, Germany. Electronic address:

Purpose: To assess the prevalence of pseudoexfoliation (PEX) and its associations in a Russian population.

Design: Population-based cross-sectional study.

Methods: Setting: Ufa capital of Bashkortostan, Russia and a rural region in Bashkortostan. Read More

Int Ophthalmol 2020 Feb 29;40(2):313-323. Epub 2019 Sep 29.

Department of Ophthalmology Hospital Abente y Lago, Complexo Hospitalario Universitario A Coruña, Plaza del Parrote s/n, 15006, A Coruña, Spain.

Purpose: To evaluate the causes of IOL explantation, techniques for secondary IOL implantation, visual outcomes and complications.

Methods: Setting: Department of Ophthalmology Complexo Hospitalario Universitario A Coruña, Spain.

Design: Retrospective study. Read More

Acta Ophthalmol 2019 Dec 6;97(8):744-751. Epub 2019 Aug 6.

Glaucoma Services, Dr Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India.

Cyclodialysis is a rare occurrence and is difficult to treat, it being concealed behind the iris. In view of the varied success outcomes of the different available surgical repair techniques, there is at present no clear consensus regarding their management strategies. Through this article, we intend to appraise the established surgical methods, update the novel techniques in vogue, discuss their outcomes and propose a uniform system to codify these corrective techniques. Read More

Graefes Arch Clin Exp Ophthalmol 2019 Nov 30;257(11):2547-2558. Epub 2019 Jul 30.

Instituto de Microcirugía Ocular (IMO), C/ Josep María Lladó 3, 08035, Barcelona, Spain.

Purpose: To evaluate the effectiveness of temporary keratoprosthesis combined with vitreoretinal surgery and penetrating keratoplasty in patients with or without trauma.

Methods: This retrospective study included 49 eyes in 49 non-trauma patients and 51 eyes in 48 ocular trauma patients who underwent penetrating keratoplasty and vitreoretinal surgery with Eckardt temporary keratoprosthesis between 2009 and 2016, with a follow-up of at least 12 months. Study variables included previous corneal, glaucoma, or retinal surgeries; various intraoperative surgical maneuvers; lens status; vitreoretinal and corneal pathology; functional outcomes; anatomical retinal reattachment; graft clarity; and need for glaucoma surgery or treatment. Read More

Eur J Ophthalmol 2020 Nov 17;30(6):1370-1380. Epub 2019 Jul 17.

Temple Street Children's University Hospital, Dublin, Ireland.

Purpose: To determine the incidence, timing and risk factors for glaucoma and visual axis opacification development following surgery for congenital cataract in the first year of life.

Methods: A prospective case series of all cataract surgery performed in Temple Street Children's University Hospital over a 28-year period was conducted. A total of 93 subjects (135 eyes) were analysed. Read More

Arch Soc Esp Oftalmol (Engl Ed) 2019 Aug 17;94(8):377-383. Epub 2019 Jun 17.

Departamento de Oftalmología, Hospital Universitario La Paz, Madrid, España.

Objective: To study elevated postoperative intraocular pressure (PIOP) after paediatric cataract surgery in a reference centre and to compare the results obtained with the most relevant world literature.

Materials And Methods: A retrospective observational study was conducted, collecting information from clinical records of 99 patients (142 eyes) operated on due to unilateral or bilateral paediatric cataracts between 2000 and 2008.

Results: The proportion of eyes with PIOP≥20mmHg and bilateral cataracts was higher, 79. Read More