6,128 results match your criteria Gilbert Syndrome


Impact of the Human Papillomavirus Immunization Program on Rates of Anogenital Warts in British Columbia, Canada 2000 - 2017.

Sex Transm Dis 2020 Jul 6. Epub 2020 Jul 6.

Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada.

Background: In 2008, British Columbia (BC) implemented a school-based HPV-4 immunization program for girls born in 1994 or later. In 2015, an expanded clinic-based program included men who report sex with men (MSM) born in 1989 or later. To evaluate impacts of HPV-4 programs on anogenital warts (AGW), diagnosis rates were measured among women who report sex with men (WSM), men who report sex with women (MSW), and MSM. Read More

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http://dx.doi.org/10.1097/OLQ.0000000000001235DOI Listing

Outcomes of obstructed abdominal wall hernia: results from the UK national small bowel obstruction audit.

Authors:

BJS Open 2020 Jul 10. Epub 2020 Jul 10.

Background: Abdominal wall hernia is a common surgical condition. Patients may present in an emergency with bowel obstruction, incarceration or strangulation. Small bowel obstruction (SBO) is a serious surgical condition associated with significant morbidity. Read More

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http://dx.doi.org/10.1002/bjs5.50315DOI Listing

NCI-CONNECT: Comprehensive Oncology Network Evaluating Rare CNS Tumors-Histone Mutated Midline Glioma Workshop Proceedings.

Neurooncol Adv 2020 Jan-Dec;2(1):vdaa007. Epub 2020 Jan 16.

Neuro-Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.

Histone mutations occur in approximately 4% of different cancer types. In 2012, mutations were found in the gene encoding histone variant H3.3 ( gene) in pediatric diffuse intrinsic pontine gliomas and pediatric hemispheric gliomas. Read More

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http://dx.doi.org/10.1093/noajnl/vdaa007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7212875PMC
January 2020

Clinical validation of the novel HDAC6 radiotracer [F]EKZ-001 in the human brain.

Eur J Nucl Med Mol Imaging 2020 Jul 8. Epub 2020 Jul 8.

Eikonizo Therapeutics, Inc., LabCentral, 700 Main Street North, Cambridge, MA, 02139, USA.

Purpose: Histone deacetylase 6 (HDAC6) is a cytoplasmic enzyme that modulates intracellular transport and protein quality control. Inhibition of HDAC6 deacetylase activity has shown beneficial effects in disease models, including Alzheimer's disease and amyotrophic lateral sclerosis. This first-in-human positron emission tomography (PET) study evaluated the brain binding of [F]EKZ-001 ([F]Bavarostat), a radiotracer selective for HDAC6, in healthy adult subjects. Read More

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http://dx.doi.org/10.1007/s00259-020-04891-yDOI Listing

SARS, MERS, COVID-19: Clinical Manifestations and Organ-System Complications: A Mini Review.

Pathog Dis 2020 Jul 7. Epub 2020 Jul 7.

Gilbert and Rose-Marie Chagoury School of Medicine, Lebanese American University, Byblos, Lebanon.

Middle East Respiratory Syndrome (MERS), Severe Acute Respiratory Syndrome (SARS) and Coronavirus Disease 2019 (COVID-19) are caused by three distinct coronaviruses belonging to the same genus. COVID-19 and its two predecessors share many important features in their clinical presentations, and in their propensity for progression to severe disease which is marked by high rates of morbidity and mortality. However, comparison of the three viral illnesses also reveals a number of specific differences in clinical manifestations and complications, which suggest variability in the disease process. Read More

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http://dx.doi.org/10.1093/femspd/ftaa033DOI Listing

Maintenance inhaler therapy preferences of patients with asthma or chronic obstructive pulmonary disease: a discrete choice experiment.

Thorax 2020 Jul 6. Epub 2020 Jul 6.

AstraZeneca, Wilmington, Delaware, USA.

Background: A variety of maintenance inhaler therapies are available to treat asthma and COPD. Patient-centric treatment choices require understanding patient preferences for the alternative therapies.

Methods: A self-completed web-based discrete choice experiment was conducted to elicit patient preferences for inhaler device and medication attributes. Read More

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http://dx.doi.org/10.1136/thoraxjnl-2019-213974DOI Listing

Prognostic Reliability of a New Classification System for Blount's Disease.

Cureus 2020 May 29;12(5):e8353. Epub 2020 May 29.

Orthopaedic Surgery, University of Alabama at Birmingham, Birmingham, USA.

Objective We conducted this study to evaluate the reproducibility of a new classification system for Blount's disease and assess its correlation with established radiological measures used to evaluate the severity of this disorder. Materials and Methods This is a retrospective review of children with Blount's disease that were younger than 10 years of age. Recurrence was defined as the need for a second corrective surgery. Read More

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http://dx.doi.org/10.7759/cureus.8353DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7325337PMC

Regulation of Thyroid Disrupting Chemicals to Protect the Developing Brain.

Endocrinology 2020 Jul 2. Epub 2020 Jul 2.

Division of Diet, Disease Prevention and Toxicology, National Food Institute, Technical University of Denmark, Kgs. Lyngby, DK, Denmark.

Manmade chemicals with endocrine disrupting properties are pervasive in the environment and are present in the bodies of humans and in wildlife. As thyroid hormones (THs) control normal brain development, and maternal hypothyroxinemia is associated with neurological impairments in children, chemicals that interfere with TH signaling are of considerable concern for children's health. However, identifying thyroid disrupting chemicals (TDCs) in vivo is largely based on serum tetraiodothyronine (T4) measures in rats, which may be inadequate to assess TDCs with disparate mechanisms of action. Read More

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http://dx.doi.org/10.1210/endocr/bqaa106DOI Listing

Treatment implications of postoperative chemoradiotherapy for squamous cell carcinoma of the oral cavity with minor and major extranodal extension.

Oral Oncol 2020 Jun 29;110:104845. Epub 2020 Jun 29.

Department of Pathology, University Health Network, Toronto, Canada.

Objectives: To evaluate adjuvant chemoradiotherapy (CRT) for patients with oral cavity squamous cell carcinoma (OSCC) with minor or major extranodal extension (ENE).

Materials And Methods: Surgically resected OSCC with pathologically involved lymph node(s) (pN+) between 2006 and 2017. Sections of pN+ were re-reviewed and classified as no, minor (≤2 mm), or major (>2 mm) ENE. Read More

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http://dx.doi.org/10.1016/j.oraloncology.2020.104845DOI Listing

Invasive Versus Conservative Management of Stable Coronary Artery Disease in CKD.

Am J Kidney Dis 2020 Jun 29. Epub 2020 Jun 29.

Tufts Medical Center, Division of Nephrology. Electronic address:

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http://dx.doi.org/10.1053/j.ajkd.2020.06.007DOI Listing

New treatment modalities in NF-related neuroglial tumors.

Childs Nerv Syst 2020 Jun 29. Epub 2020 Jun 29.

Division of Radiology, Children's National Hospital, 111 Michigan Ave, NW, Washington, DC, 20010, USA.

The management of low-grade gliomas (LGGs) and other neuroglial tumors in children with neurofibromatosis type 1 (NF1) has not changed over the past 2-3 decades. With the widespread utilization of chemotherapy for younger children with progressive LGGs, outcomes have been good for most patients who have required treatment. However, some may progress after the initiation of chemotherapy and others, although radiographically responding or with stable disease, may develop progressive neurologic and visual deterioration. Read More

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http://dx.doi.org/10.1007/s00381-020-04704-5DOI Listing

A single dose of ChAdOx1 MERS provides protective immunity in rhesus macaques.

Sci Adv 2020 Jun 10;6(24):eaba8399. Epub 2020 Jun 10.

Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rocky Mountain Laboratories, Hamilton, MT, USA.

Developing a vaccine to protect against the lethal effects of the many strains of coronavirus is critical given the current global pandemic. For Middle East respiratory syndrome coronavirus (MERS-CoV), we show that rhesus macaques seroconverted rapidly after a single intramuscular vaccination with ChAdOx1 MERS. The vaccine protected against respiratory injury and pneumonia and reduced viral load in lung tissue by several orders of magnitude. Read More

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http://dx.doi.org/10.1126/sciadv.aba8399DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7286676PMC

THE TENSILE BEHAVIORS OF THE ILIOTIBIAL BAND - A CADAVERIC INVESTIGATION.

Int J Sports Phys Ther 2020 May;15(3):451-459

Center for Rehabilitation Research, Texas Tech University Health Sciences Center, Lubbock, TX, USA.

Background: Clinical stretching is frequently recommended for iliotibial band syndrome management. Current literature lacks conclusive findings regarding isolated human iliotibial band tissue elongation and stiffness behaviors. Applying clinical-grade stretching force results to iliotibial band tissue behavior is thus challenging. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7296993PMC

Comparison Between ESC and Duke Criteria for the Diagnosis of Prosthetic Valve Infective Endocarditis.

JACC Cardiovasc Imaging 2020 Jun 17. Epub 2020 Jun 17.

APHM, La Timone Hospital, Cardiology Department, Marseille, France; Aix Marseille University, IRD, APHM, MEPHI, IHU-Méditerranée Infection, Marseille, France. Electronic address:

Objectives: The primary objective was to assess the value of the European Society of Cardiology (ESC) criteria, including F-fluorodeoxyglucose positron emission tomography/computed tomography (F-FDG-PET/CT) in prosthetic valve infective endocarditis (PVE). Secondary objectives were: 1) to assess the reproducibility of F-FDG-PET/CT; 2) to compare its diagnostic value with that of echocardiography; and 3) to assess the diagnostic value of the presence of a diffuse splenic uptake BACKGROUND: F-FDG PET/CT has been added as a major criterion in the ESC 2015 infective endocarditis (IE) guidelines, but the benefit of the ESC criteria has not been prospectively compared with the conventional Duke criteria.

Methods: Between 2014 and 2017, 175 patients with suspected PVE were prospectively included in 3 French centers. Read More

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http://dx.doi.org/10.1016/j.jcmg.2020.04.011DOI Listing

Management of Indwelling Tunneled Pleural Catheters: A Modified Delphi Consensus Statement.

Chest 2020 Jun 16. Epub 2020 Jun 16.

Division of Pulmonary and Critical Care, Johns Hopkins School of Medicine, Baltimore, Maryland, USA.

Background: The management of recurrent pleural effusions remains a challenging issue for clinicians. Advances in management have led to increased use of indwelling tunneled pleural catheters (IPC) due to their effectiveness and ease of outpatient placement. However, with the increase in IPC placement there have also been increasing reports of complications, including infections. Read More

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http://dx.doi.org/10.1016/j.chest.2020.05.594DOI Listing

Awareness of and intention to use an online sexually transmitted and blood-borne infection testing service among gay and bisexual men in British Columbia, two years after implementation.

Can J Public Health 2020 Jun 16. Epub 2020 Jun 16.

British Columbia Centre for Disease Control, 655 West 12th Avenue, Vancouver, BC, V5Z 4R4, Canada.

Objectives: This study assessed gay, bisexual, and other men who have sex with men's (GBMSM) awareness of and intention to use GetCheckedOnline, an online sexually transmitted and blood-borne infection (STBBI) testing service.

Methods: A cross-sectional study was conducted two years after launch among GBMSM > 18 years of age in British Columbia, Canada. Participants were recruited through community venues, clinics, websites, and apps. Read More

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http://dx.doi.org/10.17269/s41997-020-00323-4DOI Listing

Genetic analyses of native Fusarium head blight resistance in two spring wheat populations identifies QTL near the B1, Ppd-D1, Rht-1, Vrn-1, Fhb1, Fhb2, and Fhb5 loci.

Theor Appl Genet 2020 Jun 17. Epub 2020 Jun 17.

Morden Research and Development Centre, Agriculture and Agri-Food Canada, Morden, MB, R6M 1Y5, Canada.

Key Message: QTL analyses of two bi-parental mapping populations with AC Barrie as a parent revealed numerous FHB-resistance QTL unique to each population and uncovered novel variation near Fhb1. Fusarium head blight (FHB) is a destructive disease of wheat worldwide, leading to severe yield and quality losses. The genetic basis of native FHB resistance was examined in two populations: a recombinant inbred line population from the cross Cutler/AC Barrie and a doubled haploid (DH) population from the cross AC Barrie/Reeder. Read More

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http://dx.doi.org/10.1007/s00122-020-03631-yDOI Listing

Steroid-sparing maintenance immunotherapy for MOG-IgG associated disorder.

Neurology 2020 Jun 17. Epub 2020 Jun 17.

From the Departments of Ophthalmology (J.J.C., M.T.B.), Neurology (J.J.C., E.P.F., M.T.B., J.J., D.D., A.S.L.C., B.G.W., A.M., J.-M.T., V.A.L., C.F.L., A.K., S.J.P.), Laboratory Medicine and Pathology (E.P.F., J.J., D.D, J.P.F., A.M., V.A.L., S.J.P.), and Immunology (V.A.L.) and Center for MS and Autoimmune Neurology (E.P.F., D.D., B.G.W., A.M., V.A.L., C.F.L., A.K., S.J.P.), Mayo Clinic, Rochester, MN; Department of Ophthalmology and Visual Neurosciences (C.M.M., M.S.L.), University of Minnesota, Minneapolis; Departments of Neurology and Ophthalmology (J.L.B., V.S.P.), University of Colorado Denver School of Medicine, Aurora; Departments of Ophthalmology and Visual Sciences and Neurology (G.V.S.), Washington University, St. Louis School of Medicine, MO; Departments of Ophthalmology and Visual Science and Neurology (O.-O.O.A.), McGovern Medical School, Houston, TX; Departments of Neurology, Neurosurgery, and Neuro-Ophthalmology (E.R.E.), Mayo Clinic, Jacksonville, FL; Departments of Ophthalmology (M.D.A.) and Neurology (D.M.W.), Mayo Clinic, Scottsdale, AZ; Bascom Palmer Eye Institute (B.L.L.), University of Miami, FL; Department of Neurology and Ophthalmology (H.M., S.B.), Stanford University, Palo Alto, CA; Neuro-Ophthalmology (A.L.G.), Kaiser Permanente, Northern California, Vallejo; Department of Ophthalmology (V.S.), Baylor College of Medicine/Texas Children's Hospital, Houston; Department of Ophthalmology (G.A., D.M.C.), Massachusetts Eye and Ear Infirmary/Harvard Medical School, Boston; Department of Ophthalmology (G.H.), Boston Children's Hospital, Harvard Medical School, MA; and Neuro-Ophthalmology Unit (H.S.-K.), Department of Ophthalmology, Rabin Medical Center, Sackler School of Medicine, Tel Aviv University, Israel.

Objective: Myelin oligodendrocyte glycoprotein-immunoglobulin G (MOG-IgG) associated disorder (MOGAD) often manifests with recurrent CNS demyelinating attacks. The optimal treatment for reducing relapses is unknown. To help determine the efficacy of long-term immunotherapy in preventing relapse in patients with MOGAD, we conducted a multicenter retrospective study to determine the rate of relapses on various treatments. Read More

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http://dx.doi.org/10.1212/WNL.0000000000009758DOI Listing

The coffee ingredients caffeic acid (CA) and caffeic acid phenylethyl ester (CAPE) protect against irinotecan induced leukopenia and oxidative stress response.

Br J Pharmacol 2020 Jun 16. Epub 2020 Jun 16.

Department of Internal Medicine I, University Hospital Bonn, 53127, Bonn, Germany.

Background And Purpose: Irinotecan, a drug used in colorectal cancer therapy is metabolized by glucuronidation involving different UDP-glucuronosyltransferase (UGT)1A isoforms, which leads to facilitated elimination from the body. Individuals homozygous for the genetic variants UGT1A1*28 (Gilbert syndrome) and UGT1A7*3 are more susceptible to irinotecan drug side effects such as severe diarrhea and leukopenia. Aim of this study was to study the protective effects and active constituents of coffee during irinotecan therapy using humanized transgenic (htg)UGT1A-WT and htgUGT1A-SNP (carry UGT1A1*28 and UGT1A7*3 polymorphisms) mice. Read More

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http://dx.doi.org/10.1111/bph.15162DOI Listing

Red reflex examination in reproductive and child health clinics for early detection of paediatric cataract and ocular media disorders: cross-sectional diagnostic accuracy and feasibility studies from Kilimanjaro, Tanzania.

Eye (Lond) 2020 Jun 16. Epub 2020 Jun 16.

International Centre for Eye Health, London School of Hygiene & Tropical Medicine, London, WC1E 7HT, UK.

Background/objectives: Late presentation of congenital cataract in the developing world has led to poor outcomes such that cataract is the leading cause of childhood blindness. Our hypothesis was that, sensitivity of red-reflex testing is greater than sensitivity of torchlight examination. We aimed to compare sensitivity of new red reflex screening tools and assess the feasibility of Arclight red reflex screening in the community. Read More

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http://dx.doi.org/10.1038/s41433-020-1019-5DOI Listing

AMPA/kainate glutamate receptor antagonists prevent posttraumatic osteoarthritis.

JCI Insight 2020 Jul 9;5(13). Epub 2020 Jul 9.

School of Biosciences.

Musculoskeletal disorders represent the third greatest burden in terms of death and disability in the developed world. Osteoarthritis is the single greatest cause of chronic pain, has no cure, and affects 8.5 and 27 million people in the UK and US, respectively. Read More

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http://dx.doi.org/10.1172/jci.insight.134055DOI Listing

Microneutralization assay titer correlates analysis in two phase 3 trials of the CYD-TDV tetravalent dengue vaccine in Asia and Latin America.

PLoS One 2020 15;15(6):e0234236. Epub 2020 Jun 15.

Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America.

We previously showed that Month 13 50% plaque reduction neutralization test (PRNT50) neutralizing antibody (nAb) titers against dengue virus (DENV) correlated with vaccine efficacy (VE) of CYD-TDV against symptomatic, virologically-confirmed dengue (VCD) in the CYD14 and CYD15 Phase 3 trials. While PRNT is the gold standard nAb assay, it is time-consuming and costly. We developed a next-generation high-throughput microneutralization (MN) assay and assessed its suitability for immune-correlates analyses and immuno-bridging applications. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0234236PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7295445PMC

Antibiotic Susceptibility of NDM-Producing Collected in the United States, 2017-2018.

Antimicrob Agents Chemother 2020 Jun 15. Epub 2020 Jun 15.

Division of Healthcare Quality Promotion, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.

The treatment of infections caused by carbapenem-resistant , especially New Delhi metallo-β-lactamase (NDM)-producing bacteria, is challenging. Although less common in the United States than some other carbapenemase-producers, NDM-producing bacteria are a public health threat due to the limited treatment options available. Here we report on the antibiotic susceptibility of 275 contemporary NDM-producing collected from 30 U. Read More

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http://dx.doi.org/10.1128/AAC.00499-20DOI Listing

[Analysis of mutation site characteristics of Gilbert syndrome and Crigler--Najjar syndrome in relation to uridine diphosphate glucuronosyltransferase A1 gene].

Zhonghua Gan Zang Bing Za Zhi 2020 May;28(5):428-433

Difficult & Complicated Liver Diseases and Artificial Liver Center, Beijing Youan Hospital, Capital Medical University, Beijing 100069,China; Beijing Municipal Key Laboratory of Liver Failure and Artificial Liver Treatment Research, Beijing 100069,China.

To investigate the mutation characteristics and clinical relevance of Gilbert syndrome (GS) and Crigler-Najjar syndrome (CNS) in relation to uridine diphosphate glucuronosyltransferase A1 (UGT1A1) gene. The characteristics of UGT1A1 gene mutation and their clinical relevance were analyzed by searching PubMed and Human Gene Mutation Databases. A total of 163 mutation sites were found in the UGT1A1 gene since November 16, 2018. Read More

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http://dx.doi.org/10.3760/cma.j.cn501113-20200217-00051DOI Listing

Immersion in an emergency department triage center during the Covid-19 outbreak: first report of the Liège University hospital experience.

Acta Clin Belg 2020 Jun 12:1-7. Epub 2020 Jun 12.

Emergency Department, University Hospital Center , Liège, Belgium.

Objectives: Since the beginning of the novel coronavirus outbreak, different strategies have been explored to stem the spread of the disease and appropriately manage patient flow. Triage, an effective solution proposed in disaster medicine, also works well to manage Emergency Department (ED) flow. The aim of this study was to describe the role of an ED Triage Center for patients with suspected novel coronavirus disease (Covid-19) and characterize the patient flow. Read More

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http://dx.doi.org/10.1080/17843286.2020.1778348DOI Listing

Citizens' juries give verdict on whether private practice veterinarians should attend unvaccinated Hendra virus suspect horses.

Aust Vet J 2020 Jun 11. Epub 2020 Jun 11.

University of Wollongong, Australian Centre for Health Engagement, Evidence and Values, Wollongong, New South Wales, Australia.

Background: Hendra virus (HeV) is endemic in Australian flying foxes, posing a threat to equine and human health. Equine vaccination remains the most effective risk mitigation strategy. Many horses remain unvaccinated - even in higher-risk regions. Read More

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http://dx.doi.org/10.1111/avj.12957DOI Listing

Neurofibromatosis 1-associated optic pathway gliomas.

Childs Nerv Syst 2020 Jun 11. Epub 2020 Jun 11.

Department of Pediatric Neurosurgery, Dana Children's Hospital, Tel-Aviv Medical Center, The Gilbert Israeli International Neurofibromatosis Center (GIINFC), Tel Aviv University, 6th Weizmann St., 64239, Tel-Aviv, Israel.

Background: Optic Pathway Gliomas (OPG) are the most common brain tumor in Neurofibromatosis 1 patients (NF1). They are found along the optic pathway and may involve the optic nerves, chiasm, retro-chiasmatic structures, and the optic radiations. NF1 associate OPG (NF1-OPG) have variable presentation, disease course and response to treatment. Read More

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http://dx.doi.org/10.1007/s00381-020-04697-1DOI Listing

Presentation, surgery and 1-year outcomes of childhood cataract surgery in Tanzania.

Br J Ophthalmol 2020 Jun 10. Epub 2020 Jun 10.

Clinical Research, London School of Hygiene and Tropical Medicine, London, UK.

Background: Recent reports have suggested a significant change in the causes of blindness in children in low-income countries cataract becoming the leading cause. We aimed to investigate the presentations and surgical outcomes in children with cataract operated at different ages in Tanzania.

Methods: We conducted a prospective study of 228 children aged ≤192 months at three tertiary centres, 177 with bilateral cataracts and prospectively followed them for 1-year postsurgery. Read More

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http://dx.doi.org/10.1136/bjophthalmol-2020-316042DOI Listing

Consensus Recommendations for a Dynamic Susceptibility Contrast MRI Protocol for Use in High-Grade Gliomas.

Neuro Oncol 2020 Jun 9. Epub 2020 Jun 9.

Department of Biophysics, Medical College of Wisconsin, Milwaukee, WI.

Despite the widespread clinical use of dynamic susceptibility contrast (DSC) MRI, DSC-MRI methodology has not been standardized, hindering its utilization for response assessment in multi-center trials. Recently, the DSC-MRI Standardization Subcommittee of the Jumpstarting Brain Tumor Drug Development Coalition issued an updated consensus DSC-MRI protocol compatible with BTIP, the standardized brain tumor imaging protocol for high-grade gliomas that is increasingly used in the clinical setting and is the default MRI protocol for the National Clinical Trials Network. After reviewing the basis for controversy over DSC-MRI protocols, this manuscript provides evidence-based best practices for clinical DSC-MRI as determined by the Committee, including pulse sequence (gradient echo vs. Read More

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http://dx.doi.org/10.1093/neuonc/noaa141DOI Listing

Role, function and challenges of multidisciplinary centres for rare diseases exemplified for neurofibromatosis type 1 syndrome.

Childs Nerv Syst 2020 Jun 8. Epub 2020 Jun 8.

Centre of Neurofibromatosis at the Centre of Rare Diseases, Tuebingen University Hospital, Tuebingen, Germany.

Purpose: Neurofibromatosis type 1 (NF1) syndrome is a common rare/orphan disease that manifests itself early in the paediatric age. It imposes a considerable burden upon patients as well as on caregivers. Decisions regarding optimal care often rely on several medical instances working together as a team. Read More

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http://dx.doi.org/10.1007/s00381-020-04708-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7276654PMC

ChAdOx1 nCoV-19 vaccination prevents SARS-CoV-2 pneumonia in rhesus macaques.

bioRxiv 2020 May 13. Epub 2020 May 13.

Laboratory of Virology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA.

Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) emerged in December 2019 and is responsible for the COVID-19 pandemic. Vaccines are an essential countermeasure urgently needed to control the pandemic. Here, we show that the adenovirus-vectored vaccine ChAdOx1 nCoV-19, encoding the spike protein of SARS-CoV-2, is immunogenic in mice, eliciting a robust humoral and cell-mediated response. Read More

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http://dx.doi.org/10.1101/2020.05.13.093195DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7241103PMC

GDNF and Parkinson's Disease: Where Next? A Summary from a Recent Workshop.

J Parkinsons Dis 2020 Jun 3. Epub 2020 Jun 3.

The Edmond J Safra Program in Parkinson's Disease and the Morton and Gloria Shulman Movement Disorders Clinic, Toronto Western Hospital, and the Department of Medicine, University of Toronto, Toronto, Ontario, Canada.

The concept of repairing the brain with growth factors has been pursued for many years in a variety of neurodegenerative diseases including primarily Parkinson's disease (PD) using glial cell line-derived neurotrophic factor (GDNF). This neurotrophic factor was discovered in 1993 and shown to have selective effects on promoting survival and regeneration of certain populations of neurons including the dopaminergic nigrostriatal pathway. These observations led to a series of clinical trials in PD patients including using infusions or gene delivery of GDNF or the related growth factor, neurturin (NRTN). Read More

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http://dx.doi.org/10.3233/JPD-202004DOI Listing

Neurofibromatosis type 1-related hydrocephalus: causes and treatment considerations.

Childs Nerv Syst 2020 Jun 6. Epub 2020 Jun 6.

Pediatric Neurosurgery, Santobono-Pausilipon Children's Hospital, Naples, Italy.

The prevalence of hydrocephalus among patients with neurofibromatosis type I (NF1) is estimated to be between 1 and 13%. Most hydrocephalic causes are obstructive-aqueductal webs, chiasmatic-hypothalamic tumors, and thalamic mass effect related to NF changes. Other NF1-related conditions may mimic the clinical presentation of hydrocephalus and should be ruled out while evaluating children with headaches. Read More

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http://dx.doi.org/10.1007/s00381-020-04719-yDOI Listing

Whole-genome sequencing of a sporadic primary immunodeficiency cohort.

Nature 2020 Jul 6;583(7814):90-95. Epub 2020 May 6.

Cambridge Institute of Therapeutic Immunology and Infectious Disease, Jeffrey Cheah Biomedical Centre, Cambridge Biomedical Campus, Cambridge, UK.

Primary immunodeficiency (PID) is characterized by recurrent and often life-threatening infections, autoimmunity and cancer, and it poses major diagnostic and therapeutic challenges. Although the most severe forms of PID are identified in early childhood, most patients present in adulthood, typically with no apparent family history and a variable clinical phenotype of widespread immune dysregulation: about 25% of patients have autoimmune disease, allergy is prevalent and up to 10% develop lymphoid malignancies. Consequently, in sporadic (or non-familial) PID genetic diagnosis is difficult and the role of genetics is not well defined. Read More

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http://dx.doi.org/10.1038/s41586-020-2265-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7334047PMC
July 2020
42.351 Impact Factor

Not following the rules in guideline care for lung cancer diagnosis and staging has negative impact.

Ann Thorac Surg 2020 May 31. Epub 2020 May 31.

Division of Interventional Pulmonology and Thoracic Surgery, Swedish Cancer Institute, Seattle, WA. Electronic address:

Background: Recent studies have identified poor adherence to recommended guidelines in diagnosing and staging patients with non-small cell lung cancer (NSCLC), which has been associated with numerous negative downstream effects. However, these reports are comprised predominantly of large administrative databases with inherent limitations. We aimed to describe guideline-inconsistent care and identify any associated factors within our healthcare system. Read More

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http://dx.doi.org/10.1016/j.athoracsur.2020.04.049DOI Listing

Prior Treatment Time Affects Survival Outcomes in Metastatic Breast Cancer.

JCO Clin Cancer Inform 2020 Jun;4:500-513

School of Nursing, UAB, Birmingham, AL.

Purpose: Sequential drug treatments in metastatic breast cancer (MBC) are disparate. Clinical trial data includes limited reporting of treatment context, primarily including the number of prior therapies. This study evaluates the relationship between prior treatment time, prior lines of treatment, and survival using a novel visualization technique coupled with statistical analyses. Read More

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http://dx.doi.org/10.1200/CCI.20.00008DOI Listing

Hypofractionated radiotherapy alone with 2.4 Gy per fraction for head and neck cancer during the COVID-19 pandemic: The Princess Margaret experience and proposal.

Cancer 2020 08 1;126(15):3426-3437. Epub 2020 Jun 1.

Department of Radiation Oncology, Princess Margaret Cancer Centre/University of Toronto, Toronto, Ontario, Canada.

Background: The objective of this study was to identify a subgroup of patients with head and neck squamous cell carcinoma (HNSCC) who might be suitable for hypofractionated radiotherapy (RT-hypo) during the COVID-19 pandemic.

Methods: HNSCC cases (oropharynx/larynx/hypopharynx) treated with definitive RT-hypo (60 Gy in 25 fractions over 5 weeks), moderately accelerated radiotherapy (RT-acc) alone (70 Gy in 35 fractions over 6 weeks), or concurrent chemoradiotherapy (CCRT) during 2005-2017 were included. Locoregional control (LRC) and distant control (DC) after RT-hypo, RT-acc, and CCRT were compared for various subgroups. Read More

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http://dx.doi.org/10.1002/cncr.32968DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7300809PMC
August 2020
4.889 Impact Factor

Benzene exposure-response and risk of lymphoid neoplasms in Chinese workers: A multicenter case-cohort study.

Am J Ind Med 2020 May 31. Epub 2020 May 31.

Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Rockville, Maryland.

Background: While international agreement supports a causal relationship of benzene exposure with acute myeloid leukemia, there is debate about benzene and lymphoid neoplasm risks.

Methods: In a case-cohort study with follow-up of 110 631 Chinese workers during 1972-1999, we evaluated benzene exposure-response for non-Hodgkin lymphoma (NHL), lymphoid leukemias (LL), acute lymphocytic leukemia (ALL), and total lymphoid neoplasms (LN). We estimated benzene exposures using state-of-the-art hierarchical modeling of occupational factors calibrated with historical routine measurements and evaluated cumulative exposure-response using Cox regression. Read More

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http://dx.doi.org/10.1002/ajim.23142DOI Listing

Salvage Lung Resections After Definitive Chemoradiotherapy: A Safe and Effective Oncologic Option.

Ann Thorac Surg 2020 May 27. Epub 2020 May 27.

Swedish Cancer Institute, Division of Thoracic Surgery, 1101 Madison St, Suite 900, Seattle WA 98104.

Background: Patients with locally advanced, non-small cell lung cancer treated with definitive chemoradiotherapy alone often demonstrate persistent or recurrent disease. In the absence of systemic progression, salvage lung resection post-definitive chemoradiotherapy has been utilized as a treatment option. Given the paucity of data, we sought to evaluate the safety and efficacy of salvage pulmonary resections occurring >90 days post-definitive chemoradiotherapy. Read More

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http://dx.doi.org/10.1016/j.athoracsur.2020.04.035DOI Listing

Spondylodiscitis complicating infective endocarditis.

Heart 2020 May 28. Epub 2020 May 28.

Cardiology Department, APHM, La Timone Hospital, Marseille, France

Objective: The primary objective was to assess the characteristics and prognosis of pyogenic spondylodiscitis (PS) in patients with infective endocarditis (IE). The secondary objectives were to assess the factors associated with occurrence of PS.

Methods: Prospective case-control bi-centre study of 1755 patients with definite IE with (n=150) or without (n=1605) PS. Read More

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http://dx.doi.org/10.1136/heartjnl-2019-316492DOI Listing

Permissive microbiome characterizes human subjects with a neurovascular disease cavernous angioma.

Nat Commun 2020 May 27;11(1):2659. Epub 2020 May 27.

Section of Neurosurgery, Department of Surgery, The University of Chicago, 5841S. Maryland Avenue, Chicago, IL, 60637, USA.

Cavernous angiomas (CA) are common vascular anomalies causing brain hemorrhage. Based on mouse studies, roles of gram-negative bacteria and altered intestinal homeostasis have been implicated in CA pathogenesis, and pilot study had suggested potential microbiome differences between non-CA and CA individuals based on 16S rRNA gene sequencing. We here assess microbiome differences in a larger cohort of human subjects with and without CA, and among subjects with different clinical features, and conduct more definitive microbial analyses using metagenomic shotgun sequencing. Read More

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http://dx.doi.org/10.1038/s41467-020-16436-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7253448PMC

A Gilbert syndrome-associated haplotype protects against fatty liver disease in humanized transgenic mice.

Sci Rep 2020 May 26;10(1):8689. Epub 2020 May 26.

Department of Internal Medicine I, University Hospital Bonn, 53127, Bonn, Germany.

UDP-glucuronosyltransferases 1 A (UGT1A) enzymes are capable of detoxifying a broad range of endo- and xenobiotic compounds, which contributes to antioxidative effects, modulation of inflammation and cytoprotection. In the presence of low-function genetic UGT1A variants fibrosis development is increased in various diseases. This study aimed to examine the role of common UGT1A polymorphisms in NASH. Read More

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http://dx.doi.org/10.1038/s41598-020-65481-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7250928PMC

A Multi-Filovirus Vaccine Candidate: Co-Expression of Ebola, Sudan, and Marburg Antigens in a Single Vector.

Vaccines (Basel) 2020 May 21;8(2). Epub 2020 May 21.

Nuffield Department of Medicine, Jenner Institute, University of Oxford, Oxford OX3 7DQ, UK.

In the infectious diseases field, protective immunity against individual virus species or strains does not always confer cross-reactive immunity to closely related viruses, leaving individuals susceptible to disease after exposure to related virus species. This is a significant hurdle in the field of vaccine development, in which broadly protective vaccines represent an unmet need. This is particularly evident for filoviruses, as there are multiple family members that can cause lethal haemorrhagic fever, including Zaire ebolavirus, Sudan ebolavirus, and Marburg virus. Read More

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http://dx.doi.org/10.3390/vaccines8020241DOI Listing

Emotional violence in childhood and health conditions, risk-taking behaviors, and violence perpetration among young adults in Nigeria.

Child Abuse Negl 2020 Aug 21;106:104510. Epub 2020 May 21.

Division of Global HIV and TB, Center for Global Health, Centers for Disease Control and Prevention, Abuja, Nigeria.

Background: Globally, over 1 billion children are victims of violence against children annually. Studies examining the health consequences of childhood violence have mostly focused on childhood physical violence (PV) and sexual violence (SV). Recent evidence suggests that childhood emotional violence (EV) may also be deleterious to the health and wellbeing of victims. Read More

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http://dx.doi.org/10.1016/j.chiabu.2020.104510DOI Listing

Trajectories of hospital infection control: Using non-representational theory to understand and improve infection prevention and control.

Soc Sci Med 2020 Jul 5;256:113023. Epub 2020 May 5.

Director of the Centre for Team-based Practice & Learning in Health Care at King's College London, UK.

In this paper we undertake an innovative analysis of infection prevention and control (IPC) activities in hospitals, using non-representational theory of space (2005). We deployed video-reflexive ethnography in three wards in two metropolitan teaching hospitals involving 252 healthcare workers as participants. We analysed our data iteratively using non-representational theory, which showed hospital space being constantly produced from varied, intersecting, and sometimes competing trajectories of hospital work, objects and people. Read More

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http://dx.doi.org/10.1016/j.socscimed.2020.113023DOI Listing

Antibody and cellular responses to HIV vaccine regimens with DNA plasmid as compared with ALVAC priming: An analysis of two randomized controlled trials.

PLoS Med 2020 May 22;17(5):e1003117. Epub 2020 May 22.

Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America.

Background: DNA plasmids promise a pragmatic alternative to viral vectors for prime-boost HIV-1 vaccines. We evaluated DNA plasmid versus canarypox virus (ALVAC) primes in 2 randomized, double-blind, placebo-controlled trials in southern Africa with harmonized trial designs. HIV Vaccine Trials Network (HVTN) 111 tested DNA plasmid prime by needle or needleless injection device (Biojector) and DNA plasmid plus gp120 protein plus MF59 adjuvant boost. Read More

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http://dx.doi.org/10.1371/journal.pmed.1003117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7244095PMC

Ultra Short Echo Time MRI of Iron-Labelled Mesenchymal Stem Cells in an Ovine Osteochondral Defect Model.

Sci Rep 2020 May 21;10(1):8451. Epub 2020 May 21.

Division of Trauma and Orthopaedic Surgery, University of Cambridge, Cambridge, United Kingdom.

Multipotent Mesenchymal Stem/Stromal Cells (MSCs) are widely used in cellular therapy for joint repair. However, the use of MSC therapies is complicated by a lack of understanding of the behaviour of cells and repair within the joint. Current methods of MSC tracking include labelling the cells with Super Paramagnetic Iron Oxide nanoparticles (SPIOs). Read More

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http://dx.doi.org/10.1038/s41598-020-64423-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7242461PMC