7,010 results match your criteria Gilbert Syndrome

COVID-19 due to the B.1.617.2 (Delta) variant compared to B.1.1.7 (Alpha) variant of SARS-CoV-2: a prospective observational cohort study.

Sci Rep 2022 Jun 28;12(1):10904. Epub 2022 Jun 28.

Department of Twin Research and Genetic Epidemiology, School of Life Course Sciences, Faculty of Life Sciences and Medicine, King's College London, St Thomas' Hospital Campus, 3rd Floor South Wing Block D, Westminster Bridge Road, London, SE1 7EH, UK.

The Delta (B.1.617. Read More

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The genomic basis of the plant island syndrome in Darwin's giant daisies.

Nat Commun 2022 Jun 28;13(1):3729. Epub 2022 Jun 28.

Department of Natural History, NTNU University Museum, Norwegian University of Science and Technology, Trondheim, Norway.

The repeated, rapid and often pronounced patterns of evolutionary divergence observed in insular plants, or the 'plant island syndrome', include changes in leaf phenotypes, growth, as well as the acquisition of a perennial lifestyle. Here, we sequence and describe the genome of the critically endangered, Galápagos-endemic species Scalesia atractyloides Arnot., obtaining a chromosome-resolved, 3. Read More

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Serum Bilirubin Concentrations and the Prevalence of Gilbert Syndrome in Elite Athletes.

Sports Med Open 2022 Jun 27;8(1):84. Epub 2022 Jun 27.

Institute of Medical Biochemistry and Laboratory Diagnostics, General University Hospital in Prague and 1st Faculty of Medicine, Charles University, Na Bojišti 3, Praha 2, 12000, Prague, Czech Republic.

Objectives: Bilirubin is a potent endogenous antioxidant and immunomodulating substance, which is also implicated in both cell signalling and various metabolic pathways. Mild elevation of systemic bilirubin concentrations provides substantial protection against many diseases of civilization. Rare published reports have suggested that serum bilirubin might also be relevant to sports performance. Read More

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Analysis of the HVTN 702 Phase 2b-3 HIV-1 vaccine trial in South Africa assessing RV144 antibody and T-cell correlates of HIV-1 acquisition risk.

J Infect Dis 2022 Jun 27. Epub 2022 Jun 27.

Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, Washington 98109, USA.

Background: The ALVAC/gp120 + MF59 vaccines in the HVTN 702 efficacy trial did not prevent HIV-1 acquisition. Vaccine-matched immunological endpoints that were correlates of HIV-1 acquisition risk in RV144 were measured in HVTN 702 and evaluated as correlates of HIV-1 acquisition.

Methods: Among 1893 HVTN 702 female vaccinees, 60 HIV-1-seropositive cases and 60 matched seronegative non-cases were sampled. Read More

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Associations of meaning of illness with psychosocial, clinical, and immunological characteristics in patients with Leptomeningeal metastasis.

Compr Psychoneuroendocrinol 2021 Nov 19;8:100099. Epub 2021 Nov 19.

The University of Texas Health Science Center Cizik School of Nursing, USA.

Background: Leptomeningeal metastasis (LM) creates symptoms related to both the disease within the nervous system and treatment toxicities. Biologic processes, such as inflammation and behavioral processes, such as the meaning ascribed to illness (Meaning of Illness: MoI), can impact physical and psychosocial symptoms. The aim of this study was to understand the relationships among MoI, physical and psychosocial symptoms, and inflammation in patients with LM. Read More

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November 2021

The effect of vitamin D supplementation on cardiovascular risk in patients with prediabetes: A secondary analysis of the D2d study.

J Diabetes Complications 2022 Jun 12:108230. Epub 2022 Jun 12.

Division of Endocrinology, Diabetes and Metabolism, Tufts Medical Center, Boston, MA, United States of America.

Aims: Low blood 25(OH)D level is associated with increased cardiovascular disease (CVD) risk. Additionally, individuals with prediabetes are at higher risk for CVD than individuals with normoglycemia. We investigated the effects of vitamin D supplementation on CVD outcomes in the vitamin D and type 2 diabetes (D2d) study, a large trial among adults with prediabetes. Read More

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Viral dynamics of Omicron and Delta SARS-CoV-2 variants with implications for timing of release from isolation: a longitudinal cohort study.

Clin Infect Dis 2022 Jun 23. Epub 2022 Jun 23.

Department of Microbiology, Boston University School of Medicine, Boston, MA, USA.

Background: In January 2022, United States guidelines shifted to recommend isolation for 5 days from symptom onset, followed by 5 days of mask wearing. However, viral dynamics and variant and vaccination impact on culture conversion are largely unknown.

Methods: We conducted a longitudinal study on a university campus, collecting daily anterior nasal swabs for at least 10 days for RT-PCR and culture, with antigen rapid diagnostic testing (RDT) on a subset. Read More

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Centralizing neurofibromatosis experimental tool knowledge with the NF Research Tools Database.

Database (Oxford) 2022 Jun;2022

Sage Bionetworks, 2901 Third Ave., Suite 330, Seattle, WA 98121, USA.

Experimental tools and resources, such as animal models, cell lines, antibodies, genetic reagents and biobanks, are key ingredients in biomedical research. Investigators face multiple challenges when trying to understand the availability, applicability and accessibility of these tools. A major challenge is keeping up with current information about the numerous tools available for a particular research problem. Read More

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Economic Evaluation of Using Daily Prednisolone versus Placebo at the Time of an Upper Respiratory Tract Infection for the Management of Children with Steroid-Sensitive Nephrotic Syndrome: A Model-Based Analysis.

Pharmacoecon Open 2022 Jun 22. Epub 2022 Jun 22.

Department of Paediatric Nephrology, Nottingham Children's Hospital, Nottingham, UK.

Background: Childhood steroid-sensitive nephrotic syndrome is a frequently relapsing disease with significant short- and long-term complications, leading to high healthcare costs and reduced quality of life for patients. The majority of relapses are triggered by upper respiratory tract infections (URTIs) and evidence shows that daily low-dose prednisolone at the time of infection may reduce the risk of relapse.

Objective: The aim of this study was to assess the cost effectiveness of a 6-day course of low-dose prednisolone at the start of a URTI when compared with placebo. Read More

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A chromosome-level, fully phased genome assembly of the oat crown rust fungus Puccinia coronata f. sp. avenae: a resource to enable comparative genomics in the cereal rusts.

G3 (Bethesda) 2022 Jun 22. Epub 2022 Jun 22.

Commonwealth Scientific and Industrial Research Organisation, Agriculture and Food, Canberra, ACT, 2601, Australia.

Advances in sequencing technologies as well as development of algorithms and workflows have made it possible to generate fully phased genome references for organisms with non-haploid genomes such as dikaryotic rust fungi. To enable discovery of pathogen effectors and further our understanding of virulence evolution, we generated a chromosome-scale assembly for each of the two nuclear genomes of the oat crown rust pathogen, Puccinia coronata f. sp. Read More

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User acceptability of saliva and gargle samples for identifying COVID-19 positive high-risk workers and household contacts.

Diagn Microbiol Infect Dis 2022 May 26;104(1):115732. Epub 2022 May 26.

MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, UK. Electronic address:

Throughout the COVID-19 pandemic nasopharyngeal or nose and/or throat swabs (NTS) have been the primary approach for collecting patient samples for the subsequent detection of viral RNA. However, this procedure, if undertaken correctly, can be unpleasant and therefore deters individuals from providing high quality samples. To overcome these limitations other modes of sample collection have been explored. Read More

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Severe acute respiratory syndrome coronavirus 2 antibody seroprevalence in Lebanon: a population-based cross-sectional study.

IJID Reg 2022 Mar 29;2:184-190. Epub 2022 Jan 29.

Department of Internal Medicine, Lebanese American University Medical Centre-Rizk Hospital, Beirut, Lebanon.

Objectives: The World Health Organization has promoted the use of serological testing as a rapid and accurate technique for the detection of immunity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). In Lebanon, a better understanding of the immune response against SARS-CoV-2 is needed to develop effective measures for prevention and to plan an appropriate national vaccination program. This study aimed to measure the immunity status in Lebanon. Read More

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Vaccines based on the replication-deficient simian adenoviral vector ChAdOx1: Standardized template with key considerations for a risk/benefit assessment.

Vaccine 2022 Jun 14. Epub 2022 Jun 14.

Brighton Collaboration, a program of the Task Force for Global Health, Decatur, GA, USA.

Replication-deficient adenoviral vectors have been under investigation as a platform technology for vaccine development for several years and have recently been successfully deployed as an effective COVID-19 counter measure. A replication-deficient adenoviral vector based on the simian adenovirus type Y25 and named ChAdOx1 has been evaluated in several clinical trials since 2012. The Brighton Collaboration Benefit-Risk Assessment of VAccines by TechnolOgy (BRAVATO) was formed to evaluate the safety and other key features of new platform technology vaccines. Read More

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Association of race/ethnicity with innate immune tumor microenvironment of children with B-acute lymphoblastic leukemia.

J Immunother Cancer 2022 Jun;10(6)

Aflac Cancer and Blood Disprders Center, Children's Healthcare of Atlanta, Emory University, Atlanta, Georgia, U.S.A

Background: Black and Hispanic children with B-acute lymphoblastic leukemia (B-ALL) experience worse outcomes compared with their non-Hispanic white (NHW) counterparts. Immune-based approaches have begun to transform the therapeutic landscape in children with B-ALL. Recent studies identified several alterations in both innate and adaptive immune cells in children with B-ALL that may impact disease risk and outcome. Read More

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Genome sequence and experimental infection of calves with bovine gammaherpesvirus 4 (BoHV-4).

Arch Virol 2022 Aug 16;167(8):1659-1668. Epub 2022 Jun 16.

Department of Veterinary and Biomedical Sciences, South Dakota State University, Box 2175 North Campus Drive, Brookings, SD, 57007, USA.

Bovine gammaherpesvirus 4 (BoHV-4) is ubiquitous in cattle worldwide, and it has been detected in animals exhibiting broad clinical presentations. The virus has been detected in the United States since the 1970s; however, its clinical relevance remains unknown. Here, we determined the complete genome sequences of two contemporary BoHV-4 isolates obtained from respiratory (SD16-38) or reproductive (SD16-49) tract specimens and assessed clinical, virological, and pathological outcomes upon intranasal (IN) inoculation of calves with the respiratory BoHV-4 isolate SD16-38. Read More

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The dilemma of 12/14F ureteral access sheath (UAS) usage: a case control study.

BMC Urol 2022 Jun 15;22(1):84. Epub 2022 Jun 15.

Department of Urology, University Hospital Schleswig-Holstein, Campus Lübeck, Ratzeburger Allee 160, 23562, Lübeck, Germany.

Background: The insertion of a ureteral access sheath (UAS) is a frequent procedure during flexible ureteroscopy (fURS) to facilitate kidney stone treatment. The aim of this study was to investigate the influence of 12/14 French (F) UAS on fURS outcomes.

Methods: We performed a retrospective monocentric analysis of fURS procedures conducted at the Department of Urology (University Hospital Schleswig-Holstein, Lübeck, Germany) for kidney stone treatment via lithotripsy or basket stone retrieval between September 2013 and June 2017. Read More

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A Brief History of Human Challenge Studies (1900-2021) Emphasising the Virology, Regulatory and Ethical Requirements, Raison D'etre, Ethnography, Selection of Volunteers and Unit Design.

Curr Top Microbiol Immunol 2022 Jun 16. Epub 2022 Jun 16.

Wellcome Trust, 215 Euston Road, London, NW1 2BE, UK.

Venetian quarantine 400 years ago was an important public health measure. Since 1900 this has been refined to include "challenge" or deliberate infection with pathogens be they viruses, bacteria, or parasites. Our focus is virology and ranges from the early experiments in Cuba with Yellow Fever Virus to the most widespread pathogen of our current times, COVID-19. Read More

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Trajectories of disease activity in patients with JIA in the Childhood Arthritis and Rheumatology Research Alliance Registry.

Rheumatology (Oxford) 2022 Jun 15. Epub 2022 Jun 15.

Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL, USA.

Objective: To describe 2-year trajectories of the clinical Juvenile Arthritis Disease Activity Score, 10 joints (cJADAS10) and associated baseline characteristics in patients with juvenile idiopathic arthritis (JIA).

Methods: JIA patients in the Childhood Arthritis and Rheumatology Research Alliance Registry enrolled within 3 months of diagnosis from June 15, 2015 to December 6, 2017 with at least 2 cJADAS10 scores and 24 months of follow-up were included. Latent growth curve models of cJADAS10 were analyzed; a combination of Bayesian information criterion, posterior probabilities, and clinical judgement were used to select model of best fit. Read More

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PROcalcitonin and NEWS2 evaluation for Timely identification of sepsis and Optimal use of antibiotics in the emergency department (PRONTO): protocol for a multicentre, open-label, randomised controlled trial.

BMJ Open 2022 Jun 13;12(6):e063424. Epub 2022 Jun 13.

Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, UK.

Introduction: Sepsis is a common, potentially life-threatening complication of infection. The optimal treatment for sepsis includes prompt antibiotics and intravenous fluids, facilitated by its early and accurate recognition. Currently, clinicians identify and assess severity of suspected sepsis using validated clinical scoring systems. Read More

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Trauma, Mental Health Distress, and Infectious Disease Prevention Among Women Recently Released From Incarceration.

Front Psychiatry 2022 20;13:867445. Epub 2022 May 20.

Department of Psychiatry, University of Rochester School of Medicine, Rochester, NY, United States.

Background: U.S. women recently released from incarceration experience significantly higher rates of trauma and exacerbation of mental health conditions, and the period following release has been identified as a window of heightened risk for mental health distress and human immunodeficiency virus (HIV), sexually transmitted infections (STI) and hepatitis C (HCV) transmissions. Read More

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Paradoxes of pandemic infection control: Proximity, pace and care within and beyond SARS-CoV-2.

SSM Qual Res Health 2022 Dec 7;2:100110. Epub 2022 Jun 7.

The Marie Bashir Institute for Infectious Disease and Biosecurity, University of Sydney, Westmead Institute for Medical Research, 176 Hawkesbury Road, Westmead, NSW, 2145, Australia.

From the adoption of mask-wearing in public settings to the omnipresence of hand-sanitising, the SARS-CoV-2 pandemic has brought unprecedented cultural attention to infection prevention and control (IPC) in everyday life. At the same time, the pandemic threat has enlivened and unsettled hospital IPC processes, fracturing confidence, demanding new forms of evidence, and ultimately involving a rapid reassembling of what constitutes safe care. Here, drawing on semi-structured interviews with 63 frontline healthcare workers from two states in Australia, interviewed between September 2020 and March 2021, we illuminate some of the affective dimensions of IPC at a time of rapid change and evolving uncertainty. Read More

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December 2022

COVID-19 trajectories among 57 million adults in England: a cohort study using electronic health records.

Lancet Digit Health 2022 Jul 9;4(7):e542-e557. Epub 2022 Jun 9.

Institute of Health Informatics, University College London, London, UK; British Heart Foundation Research Accelerator, University College London, London, UK; University College London Hospitals Biomedical Research Centre, University College London, London, UK; British Heart Foundation Data Science Centre, Health Data Research UK, London, UK; Health Data Research UK, London, UK. Electronic address:

Background: Updatable estimates of COVID-19 onset, progression, and trajectories underpin pandemic mitigation efforts. To identify and characterise disease trajectories, we aimed to define and validate ten COVID-19 phenotypes from nationwide linked electronic health records (EHR) using an extensible framework.

Methods: In this cohort study, we used eight linked National Health Service (NHS) datasets for people in England alive on Jan 23, 2020. Read More

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Multimodal Data Integration Reveals Mode of Delivery and Snack Consumption Outrank Salivary Microbiome in Association With Caries Outcome in Thai Children.

Front Cell Infect Microbiol 2022 23;12:881899. Epub 2022 May 23.

Department of Public and Ecosystem Health, Cornell University Master of Public Health Program, Ithaca, NY, United States.

Early childhood caries (ECC) is not only the most common chronic childhood disease but also disproportionately affects underserved populations. Of those, children living in Thailand have been found to have high rates of ECC and severe ECC. Frequently, the cause of ECC is blamed on a handful of cariogenic organisms, such as and . Read More

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Radiotherapy to the prostate for men with metastatic prostate cancer in the UK and Switzerland: Long-term results from the STAMPEDE randomised controlled trial.

PLoS Med 2022 Jun 7;19(6):e1003998. Epub 2022 Jun 7.

Weston Park Cancer Centre, Sheffield, United Kingdom.

Background: STAMPEDE has previously reported that radiotherapy (RT) to the prostate improved overall survival (OS) for patients with newly diagnosed prostate cancer with low metastatic burden, but not those with high-burden disease. In this final analysis, we report long-term findings on the primary outcome measure of OS and on the secondary outcome measures of symptomatic local events, RT toxicity events, and quality of life (QoL).

Methods And Findings: Patients were randomised at secondary care sites in the United Kingdom and Switzerland between January 2013 and September 2016, with 1:1 stratified allocation: 1,029 to standard of care (SOC) and 1,032 to SOC+RT. Read More

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"Syndemic moral distress": sexual health provider practices in the context of co-occurring, socially produced sexual and mental health epidemics.

BMC Health Serv Res 2022 Jun 6;22(1):750. Epub 2022 Jun 6.

BC Centre for Disease Control, 655 West 12th Avenue, Vancouver, BC, V5Z4R4, Canada.

Background: 'Syndemic' refers to socially produced, intertwined, and co-occurring epidemics. Syndemic theory is increasingly used to understand the population-level relationships between sexual health (including HIV) and mental health (including problematic substance use) epidemics. Syndemic-informed clinical interventions are rare. Read More

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Primary myelofibrosis with thrombophilia as first symptom combined with thalassemia and Gilbert syndrome: A case report.

World J Clin Cases 2022 May;10(13):4161-4170

Department of Hematology, Peking Union Medical College Hospital, Beijing 100730, China.

Background: A 46-year-old Han man first had sigmoid sinus and transverse sinus venous thrombosis at the age of 42. At the age of 44, he once again developed thrombosis. Genetic testing showed heterozygous SERPINC1 mutation, bone marrow biopsy showed fibrosis grade 1 (MF-1), and JAK2 V617F mutation was positive, accompanied by UGT1A1 mutation and β-thalassemia gene mutation. Read More

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COVID-19 Misinformation on Social Media: A Scoping Review.

Cureus 2022 Apr 29;14(4):e24601. Epub 2022 Apr 29.

Medical and Behavioral Research; Health Informatics; Medical Education, Nova Southeastern University, Fort Lauderdale, USA.

Social media allows for easy access and sharing of information in real-time. Since the beginning of the coronavirus disease (COVID-19) pandemic, social media has been used as a tool for public health officials to spread valuable information. However, many Internet users have also used it to spread misinformation, commonly referred to as "fake news. Read More

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Prognostic factors for patients with anal cancer treated with conformal radiotherapy-a systematic review.

BMC Cancer 2022 Jun 3;22(1):607. Epub 2022 Jun 3.

Leeds Institute of Medical Research, University of Leeds, Beckett Street, Leeds, LS9 7TF, UK.

Aims: Anal cancer is primarily treated using concurrent chemoradiotherapy (CRT), with conformal techniques such as intensity modulated radiotherapy (IMRT) and volumetric arc therapy (VMAT) now being the standard techniques utilised across the world. Despite this, there is still very limited consensus on prognostic factors for outcome following conformal CRT. This systematic review aims to evaluate the existing literature to identify prognostic factors for a variety of oncological outcomes in anal cancer, focusing on patients treated with curative intent using contemporary conformal radiotherapy techniques. Read More

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Three-Year Follow-Up of KTE-X19 in Patients With Relapsed/Refractory Mantle Cell Lymphoma, Including High-Risk Subgroups, in the ZUMA-2 Study.

J Clin Oncol 2022 Jun 4:JCO2102370. Epub 2022 Jun 4.

University of Rochester Medical Center, Rochester, NY.

Purpose: Brexucabtagene autoleucel (KTE-X19) autologous anti-CD19 chimeric antigen receptor (CAR) T-cell therapy is approved for the treatment of relapsed/refractory mantle cell lymphoma (MCL). Outcomes after a 3-year follow-up in the pivotal ZUMA-2 study of KTE-X19 in relapsed/refractory MCL are reported, including for subgroups by prior therapy (bendamustine and type of Bruton tyrosine kinase inhibitor [BTKi]) or high-risk characteristics.

Methods: Patients with relapsed/refractory MCL (one to five prior therapies, including prior BTKi exposure) received a single infusion of KTE-X19 (2 × 10 CAR T cells/kg). Read More

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