5,664 results match your criteria Gilbert Syndrome


Effect of UDP-glucuronosyltransferase 1A1 activity on risk for developing Gilbert's syndrome.

Kaohsiung J Med Sci 2019 Apr 24. Epub 2019 Apr 24.

Department of Clinical Pathology, Cathay General Hospital, Taipei, Taiwan.

Variations at the six nucleotides -3279 (T > G), -53 (A[TA] TAA > A[TA] TAA), 211 (G > A), 686 (C > A), 1091 (C > T), and 1456 (T > G) in the UDP-glucuronosyltransferase 1A1 (UGT1A1) gene were determined in 178 Taiwanese patients with Gilbert's syndrome and in 200 healthy adults. Every subject was classified as a genotype depending on variation status of the six nucleotides in the UGT1A1 gene. The UGT1A1 activity for each genotype was calculated and then those genotypes were divided into 10 subgroups (Q1~Q10) according to their UGT1A1 activities, by using 10% as an interval. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/kjm2.12077DOI Listing

Contrasting effects of host species and phylogenetic diversity on the occurrence of HPAI H5N1 in European wild birds.

J Anim Ecol 2019 Apr 19. Epub 2019 Apr 19.

Resource Ecology Group, Wageningen University, 6708PB, Wageningen, The Netherlands.

Studies on the highly pathogenic avian influenza (HPAI) H5N1 suggest that wild bird migration may facilitate its long-distance spread, yet the role of wild bird community composition in its transmission risk remains poorly understood. Furthermore, most studies on the diversity-disease relationship focused on host species diversity without considering hosts' phylogenetic relationships, which may lead to rejecting a species diversity effect when the community has host species that are only distantly related. Here, we explored the influence of waterbird community composition for determining HPAI H5N1 occurrence in wild birds in a continental-scale study across Europe. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/1365-2656.12997DOI Listing

CPHLN recommendations for the laboratory detection of Shiga toxin-producing (O157 and non-O157).

Can Commun Dis Rep 2018 Nov 1;44(11):304-307. Epub 2018 Nov 1.

National Microbiology Laboratory, MB & ON.

Shiga toxin-producing (STEC) are important enteric pathogens responsible for sporadic cases and outbreaks of gastroenteritis. O157:H7/NM (STEC O157) are the most commonly known STEC serotypes but it is now increasingly apparent that non-O157 STEC serotypes have been underreported in the past because they were not part of routine screening in many front-line laboratories. The Canadian Public Health Laboratory Network (CPHLN) has identified the need for improved detection and surveillance of non-O157 STEC and has developed the following recommendations to assist in the decision-making process for clinical and reference microbiology laboratories. Read More

View Article

Download full-text PDF

Source
https://www.canada.ca/content/dam/phac-aspc/documents/servic
Publisher Site
http://dx.doi.org/10.14745/ccdr.v44i11a06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449107PMC
November 2018
2 Reads

Hypoglycemia in People with Type 2 Diabetes and CKD.

Clin J Am Soc Nephrol 2019 Apr 17. Epub 2019 Apr 17.

Kidney Research Institute.

Background And Objectives: Among people with diabetes mellitus, CKD may promote hypoglycemia through altered clearance of glucose-lowering medications, decreased kidney gluconeogenesis, and blunted counter-regulatory response. We conducted a prospective observational study of hypoglycemia among 105 individuals with type 2 diabetes treated with insulin or a sulfonylurea using continuous glucose monitors.

Design, Setting, Participants & Measurements: We enrolled 81 participants with CKD, defined as eGFR<60 ml/min per 1. Read More

View Article

Download full-text PDF

Source
http://cjasn.asnjournals.org/lookup/doi/10.2215/CJN.11650918
Publisher Site
http://dx.doi.org/10.2215/CJN.11650918DOI Listing
April 2019
2 Reads

Atrasentan and renal events in patients with type 2 diabetes and chronic kidney disease (SONAR): a double-blind, randomised, placebo-controlled trial.

Lancet 2019 Apr 12. Epub 2019 Apr 12.

Department of Clinical Pharmacy and Pharmacology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands.

Background: Short-term treatment for people with type 2 diabetes using a low dose of the selective endothelin A receptor antagonist atrasentan reduces albuminuria without causing significant sodium retention. We report the long-term effects of treatment with atrasentan on major renal outcomes.

Methods: We did this double-blind, randomised, placebo-controlled trial at 689 sites in 41 countries. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/S0140-6736(19)30772-XDOI Listing
April 2019
2 Reads

Brain network disintegration as a final common pathway for delirium: a systematic review and qualitative meta-analysis.

Neuroimage Clin 2019 Apr 3;23:101809. Epub 2019 Apr 3.

Department of Intensive Care Medicine and Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht University, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands.

Delirium is an acute neuropsychiatric syndrome characterized by altered levels of attention and awareness with cognitive deficits. It is most prevalent in elderly hospitalized patients and related to poor outcomes. Predisposing risk factors, such as older age, determine the baseline vulnerability for delirium, while precipitating factors, such as use of sedatives, trigger the syndrome. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.nicl.2019.101809DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461601PMC
April 2019
1 Read

Postoperative hyperbilirubinemia and Gilbert's syndrome in patients undergoing cardiac surgery.

Ann Card Anaesth 2019 Apr-Jun;22(2):207-209

Department of Surgery, University of Santiago de Compostela; Service of Cardiac Surgery, University Hospital, Santiago de Compostela, Spain.

We report a series of seven patients with Gilbert's syndrome undergoing cardiac surgery. Early and transient increase of total, direct, and indirect bilirubin without other complications was observed. Although this is a benign process, we believe that this disease should be routinely included in the differential diagnosis of postoperative jaundice after cardiopulmonary bypass. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4103/aca.ACA_48_18DOI Listing

Chronic hepatitis B virus infection and total and cause-specific mortality: a prospective cohort study of 0.5 million people.

BMJ Open 2019 Apr 9;9(4):e027696. Epub 2019 Apr 9.

Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China.

Objectives: Chronic hepatitis B virus (HBV) infection is associated with a higher risk of liver diseases. Substantial uncertainty remains, however, about the associations of HBV infection with mortality from extrahepatic causes, especially from subtypes of cardiovascular diseases. We prospectively examined the association of chronic HBV infection with total and cause-specific mortality. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bmjopen-2018-027696DOI Listing
April 2019
1 Read

Preclinical candidate for the treatment of visceral leishmaniasis that acts through proteasome inhibition.

Proc Natl Acad Sci U S A 2019 Apr 8. Epub 2019 Apr 8.

Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee DD1 5EH, United Kingdom;

Visceral leishmaniasis (VL), caused by the protozoan parasites and , is one of the major parasitic diseases worldwide. There is an urgent need for new drugs to treat VL, because current therapies are unfit for purpose in a resource-poor setting. Here, we describe the development of a preclinical drug candidate, GSK3494245/DDD01305143/compound 8, with potential to treat this neglected tropical disease. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.1820175116DOI Listing
April 2019
2 Reads

Osteoarthritis- a systematic review of long-term safety implications for osteoarthritis of the knee.

BMC Musculoskelet Disord 2019 Apr 9;20(1):151. Epub 2019 Apr 9.

Australasian College of Sport and Exercise Physicians, 257 Collins Street, Melbourne, VIC, 3000, Australia.

Background: There is no cure for knee osteoarthritis (KOA) and typically patients live approximately 30-years with the disease. Most common medical treatments result in short-term palliation of symptoms with little consideration of long-term risk. This systematic review aims to appraise the current evidence for the long-term (≥12 months) safety of common treatments for knee osteoarthritis (KOA). Read More

View Article

Download full-text PDF

Source
https://bmcmusculoskeletdisord.biomedcentral.com/articles/10
Publisher Site
http://dx.doi.org/10.1186/s12891-019-2525-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454763PMC
April 2019
6 Reads

The Landscape of L1 Retrotransposons in the Human Genome Is Shaped by Pre-insertion Sequence Biases and Post-insertion Selection.

Mol Cell 2019 Mar 29. Epub 2019 Mar 29.

Université Côte d'Azur, Inserm, CNRS, IRCAN, Nice, France. Electronic address:

L1 retrotransposons are transposable elements and major contributors of genetic variation in humans. Where L1 integrates into the genome can directly impact human evolution and disease. Here, we experimentally induced L1 retrotransposition in cells and mapped integration sites at nucleotide resolution. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.molcel.2019.02.036DOI Listing
March 2019
1 Read
14.018 Impact Factor

Constitutive STAT5 activation regulates Paneth and Paneth-like cells to control colitis.

Life Sci Alliance 2019 Apr 4;2(2). Epub 2019 Apr 4.

Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children's Hospital Medical Center (CCHMC), Cincinnati, OH, USA

impairs Paneth cells, driving intestinal inflammation that exaggerates colitis. Besides secreting bactericidal products to restrain , Paneth cells act as guardians that constitute a niche for intestinal epithelial stem cell (IESC) regeneration. However, how IESCs are sustained to specify Paneth-like cells as their niche remains unclear. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.26508/lsa.201900296DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451325PMC
April 2019
2 Reads

Perspectives of Australian policy-makers on the potential benefits and risks of technologically enhanced communicable disease surveillance - a modified Delphi survey.

Health Res Policy Syst 2019 Apr 4;17(1):35. Epub 2019 Apr 4.

Sydney Health Ethics, Sydney School of Public Health, University of Sydney, Sydney, NSW, Australia.

Background: Event-based social media monitoring and pathogen whole genome sequencing (WGS) will enhance communicable disease surveillance research and systems. If linked electronically and scanned systematically, the information provided by these technologies could be mined to uncover new epidemiological patterns and associations much faster than traditional public health approaches. The benefits of earlier outbreak detection are significant, but implementation could be opposed in the absence of a social licence or if ethical and legal concerns are not addressed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12961-019-0440-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449976PMC

Pharmacomicrobiomics: The holy grail to variability in drug response?

Clin Pharmacol Ther 2019 Apr 2. Epub 2019 Apr 2.

Department of Pediatrics, University of California San Diego School of Medicine, La Jolla, CA, 92093.

The human body, with 3.0×10 cells and more than 3.8×10 microorganisms, has nearly a one-to-one ratio of resident microbes to human cells. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/cpt.1437DOI Listing
April 2019
2 Reads

Prediction of VRC01 neutralization sensitivity by HIV-1 gp160 sequence features.

PLoS Comput Biol 2019 Apr 1;15(4):e1006952. Epub 2019 Apr 1.

Vaccine and Infectious Disease Division and Statistical Center for HIV/AIDS Research and Prevention, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America.

The broadly neutralizing antibody (bnAb) VRC01 is being evaluated for its efficacy to prevent HIV-1 infection in the Antibody Mediated Prevention (AMP) trials. A secondary objective of AMP utilizes sieve analysis to investigate how VRC01 prevention efficacy (PE) varies with HIV-1 envelope (Env) amino acid (AA) sequence features. An exhaustive analysis that tests how PE depends on every AA feature with sufficient variation would have low statistical power. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1371/journal.pcbi.1006952DOI Listing
April 2019
3 Reads

Public preferences for One Health approaches to emerging infectious diseases: A discrete choice experiment.

Soc Sci Med 2019 May 14;228:164-171. Epub 2019 Mar 14.

Marie Bashir Institute for Emerging Infections and Biosecurity, Australia; Australian Centre for Health Engagement, Evidence and Values, School of Health and Society, University of Wollongong, Australia.

There is increasing scientific consensus that a One Health approach (acknowledging links between human, animal and environmental health) is the most effective way of responding to emerging infectious disease (EID) threats. However, reviews of past EID events show that successful implementation of control strategies hinge on alignment with public values. Given the limited evidence about public values in this area, we sought to understand public preferences for attributes associated with One Health strategies for EID prevention and control, using a discrete choice experiment (DCE). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.socscimed.2019.03.013DOI Listing

Covert pathogenesis: Transient exposures to microbes as triggers of disease.

PLoS Pathog 2019 03 28;15(3):e1007586. Epub 2019 Mar 28.

Department of Obstetrics and Gynecology, Center for Reproductive Health Sciences, Center for Women's Infectious Disease Research, Washington University School of Medicine, St. Louis, Missouri, United States of America.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1371/journal.ppat.1007586DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6438445PMC
March 2019
1 Read

Recent advances in the development and evaluation of molecular diagnostics for Ebola virus disease.

Expert Rev Mol Diagn 2019 Apr 5;19(4):325-340. Epub 2019 Apr 5.

a HerpeZ , University Teaching hospital , Lusaka , Zambia.

Introduction: The 2014-16 outbreak of ebola virus disease (EVD) in West Africa resulted in 11,308 deaths. During the outbreak only 60% of patients were laboratory confirmed and global health authorities have identified the need for accurate and readily deployable molecular diagnostics as an important component of the ideal response to future outbreaks, to quickly identify and isolate patients. Areas covered: Currently PCR-based techniques and rapid diagnostic tests (RDTs) that detect antigens specific to EVD infections dominate the diagnostic landscape, but recent advances in biosensor technologies have led to novel approaches for the development of EVD diagnostics. Read More

View Article

Download full-text PDF

Source
https://www.tandfonline.com/doi/full/10.1080/14737159.2019.1
Publisher Site
http://dx.doi.org/10.1080/14737159.2019.1595592DOI Listing
April 2019
3 Reads
3.516 Impact Factor

Peptide Receptor Radionuclide Therapy for Patients With Advanced Lung Carcinoids.

Clin Lung Cancer 2019 Mar 1. Epub 2019 Mar 1.

Mayo Clinic Cancer Center, Rochester, MN. Electronic address:

Neuroendocrine neoplasms (NEN) are a family of malignancies of diverse origin, including the lung, gastrointestinal tract, and pancreas. Lung NEN include well differentiated neuroendocrine tumors (NET) classified as typical carcinoids or atypical carcinoids, and poorly differentiated neuroendocrine carcinomas classified as small-cell lung carcinoma or large-cell neuroendocrine carcinoma. According to a recent analysis of a large, population-based registry, approximately one-third of all patients with lung typical/atypical carcinoids have distant metastases at diagnosis, and median survival for these patients is 24 months. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cllc.2019.02.007DOI Listing
March 2019
2 Reads

Safety and Immunogenicity of the Heterosubtypic Influenza A Vaccine MVA-NP+M1 Manufactured on the AGE1.CR.pIX Avian Cell Line.

Vaccines (Basel) 2019 Mar 22;7(1). Epub 2019 Mar 22.

The Jenner Institute, University of Oxford, ORCRB, Roosevelt Drive, Oxford, OX3 7DQ, UK.

Seasonal influenza infections have a significant global impact leading to increased health and economic burden. The efficacy of currently available seasonal influenza vaccines targeting polymorphic surface antigens has historically been suboptimal. Cellular immune responses against highly conserved Influenza A virus antigens, such as nucleoprotein (NP) and matrix protein-1 (M1), have previously been shown to be associated with protection from disease, whilst viral-vectored vaccines are an effective strategy to boost cell-mediated immunity. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/vaccines7010033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6466103PMC
March 2019
1 Read

Publisher Correction: Past and future spread of the arbovirus vectors Aedes aegypti and Aedes albopictus.

Nat Microbiol 2019 May;4(5):900

School of BioSciences, University of Melbourne, Parkville, Victoria, Australia.

In the version of this Article originally published, the affiliation for author Catherine Linard was incorrectly stated as 'Department of Infectious Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, UK'. The correct affiliation is 'Spatial Epidemiology Lab (SpELL), Universite Libre de Bruxelles, Brussels, Belgium'. The affiliation for author Hongjie Yu was also incorrectly stated as 'Department of Statistics, Harvard University, Cambridge, MA, USA'. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41564-019-0429-2DOI Listing
May 2019
1 Read

2018 EULAR recommendations for a core data set to support observational research and clinical care in giant cell arteritis.

Ann Rheum Dis 2019 Mar 21. Epub 2019 Mar 21.

Department of Rheumatology and Clinical Immunology, Charité University Medicine Berlin, Berlin, Germany.

Giant cell arteritis (GCA) represents the most common form of primary systemic vasculitis and is frequently associated with comorbidities related to the disease itself or induced by the treatment. Systematically collected data on disease course, treatment and outcomes of GCA remain scarce. The aim of this EULAR Task Force was to identify a core set of items which can easily be collected by experienced clinicians, in order to facilitate collaborative research into the course and outcomes of GCA. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/annrheumdis-2018-214755DOI Listing
March 2019
1 Read

Neoantigen-directed immune escape in lung cancer evolution.

Nature 2019 Mar 20;567(7749):479-485. Epub 2019 Mar 20.

Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, University College London, London, UK.

The interplay between an evolving cancer and a dynamic immune microenvironment remains unclear. Here we analyse 258 regions from 88 early-stage, untreated non-small-cell lung cancers using RNA sequencing and histopathology-assessed tumour-infiltrating lymphocyte estimates. Immune infiltration varied both between and within tumours, with different mechanisms of neoantigen presentation dysfunction enriched in distinct immune microenvironments. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41586-019-1032-7DOI Listing
March 2019
8 Reads

Lysyl-tRNA synthetase as a drug target in malaria and cryptosporidiosis.

Proc Natl Acad Sci U S A 2019 Apr 20;116(14):7015-7020. Epub 2019 Mar 20.

Wellcome Centre for Anti-Infectives Research, Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, University of Dundee, DD1 5EH Dundee, United Kingdom;

Malaria and cryptosporidiosis, caused by apicomplexan parasites, remain major drivers of global child mortality. New drugs for the treatment of malaria and cryptosporidiosis, in particular, are of high priority; however, there are few chemically validated targets. The natural product cladosporin is active against blood- and liver-stage and in cell-culture studies. Read More

View Article

Download full-text PDF

Source
http://www.pnas.org/lookup/doi/10.1073/pnas.1814685116
Publisher Site
http://dx.doi.org/10.1073/pnas.1814685116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6452685PMC
April 2019
13 Reads

Sotos Syndrome Presenting with Neonatal Hyperinsulinaemic Hypoglycaemia, Extensive Thrombosis, and Multisystem Involvement.

Horm Res Paediatr 2019 Mar 15:1-7. Epub 2019 Mar 15.

Department of Endocrinology, Great Ormond Street Hospital for Children NHS Foundation Trust, London, United Kingdom.

Initially described as an uncommon presenting feature of Sotos syndrome (SoS), over the last decades, congenital hyperinsulinaemic hypoglycaemia (CHI) has been increasingly reported in association with this condition. The mechanism responsible for CHI in SoS is unclear. We report the case of a neonate presenting with CHI and extensive venous and arterial thrombosis associated with kidney, heart, liver, skeleton, and brain abnormalities and finally diagnosed with SoS on whole genome sequencing. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000496545DOI Listing
March 2019
2 Reads

Cellular response to small molecules that selectively stall protein synthesis by the ribosome.

PLoS Genet 2019 03 15;15(3):e1008057. Epub 2019 Mar 15.

Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, California, United States of America.

Identifying small molecules that inhibit protein synthesis by selectively stalling the ribosome constitutes a new strategy for therapeutic development. Compounds that inhibit the translation of PCSK9, a major regulator of low-density lipoprotein cholesterol, have been identified that reduce LDL cholesterol in preclinical models and that affect the translation of only a few off-target proteins. Although some of these compounds hold potential for future therapeutic development, it is not known how they impact the physiology of cells or ribosome quality control pathways. Read More

View Article

Download full-text PDF

Source
http://dx.plos.org/10.1371/journal.pgen.1008057
Publisher Site
http://dx.doi.org/10.1371/journal.pgen.1008057DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6436758PMC
March 2019
8 Reads

Ablation of the calpain-targeted site in cardiac myosin binding protein-C is cardioprotective during ischemia-reperfusion injury.

J Mol Cell Cardiol 2019 Mar 9;129:236-246. Epub 2019 Mar 9.

Department of Cell and Molecular Physiology, Loyola University Chicago, Maywood, IL, USA; Heart, Lung and Vascular Institute, Division of Cardiovascular Health and Disease, Department of Internal Medicine, University of Cincinnati, Cincinnati, OH, USA. Electronic address:

Cardiac myosin binding protein-C (cMyBP-C) phosphorylation is essential for normal heart function and protects the heart from ischemia-reperfusion (I/R) injury. It is known that protein kinase-A (PKA)-mediated phosphorylation of cMyBP-C prevents I/R-dependent proteolysis, whereas dephosphorylation of cMyBP-C at PKA sites correlates with its degradation. While sites on cMyBP-C associated with phosphorylation and proteolysis co-localize, the mechanisms that link cMyBP-C phosphorylation and proteolysis during cardioprotection are not well understood. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.yjmcc.2019.03.006DOI Listing
March 2019
2 Reads

49 Combinatorial Pharmacogenomics to Guide Treatment Selection for Major Depressive Disorder: A Large, Blinded, Randomized Controlled Trial.

CNS Spectr 2019 Feb;24(1):202-203

11Comprehensive Depression Center and Department of Psychiatry,and National Network of Depression Centers,University of Michigan,Ann Arbor,MI.

Background: Major depressive disorder (MDD) is a leading cause of disease burden worldwide, with lifetime prevalence in the United States of 17%. Here we present the results of the first prospective, large-scale, patient- and rater-blind, randomized controlled trial evaluating the clinical importance of achieving congruence between combinatorial pharmacogenomic (PGx) testing and medication selection for MDD.

Methods: 1,167 outpatients diagnosed with MDD and an inadequate response to ≥1 psychotropic medications were enrolled and randomized 1:1 to a Treatment as Usual (TAU) arm or PGx-guided care arm. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1017/S1092852919000415DOI Listing
February 2019

Causal associations of blood lipids with risk of ischemic stroke and intracerebral hemorrhage in Chinese adults.

Nat Med 2019 Apr 11;25(4):569-574. Epub 2019 Mar 11.

Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK.

Stroke is the second leading cause of death worldwide and accounts for >2 million deaths annually in China. Ischemic stroke (IS) and intracerebral hemorrhage (ICH) account for an equal number of deaths in China, despite a fourfold greater incidence of IS. Stroke incidence and ICH proportion are higher in China than in Western populations, despite having a lower mean low-density lipoprotein cholesterol (LDL-C) concentration. Read More

View Article

Download full-text PDF

Source
http://www.nature.com/articles/s41591-019-0366-x
Publisher Site
http://dx.doi.org/10.1038/s41591-019-0366-xDOI Listing
April 2019
34 Reads

Cardiovascular safety and lower severe hypoglycaemia of insulin degludec versus insulin glargine U100 in patients with type 2 diabetes aged 65 years or older: Results from DEVOTE (DEVOTE 7).

Diabetes Obes Metab 2019 Mar 8. Epub 2019 Mar 8.

University of North Carolina School of Medicine, Chapel Hill, North Carolina.

Aims: The aim of this study was to describe the risks of cardiovascular (CV) events and severe hypoglycaemia with insulin degludec (degludec) vs insulin glargine 100 units/mL (glargine U100) in patients with type 2 diabetes (T2D) aged 65 years or older.

Materials And Methods: A total of 7637 patients in the DEVOTE trial, a treat-to-target, randomized, double-blind trial evaluating the CV safety of degludec vs glargine U100, were divided into three age groups (50-64 years, n = 3682; 65-74 years, n = 3136; ≥75 years, n = 819). Outcomes by overall age group and randomized treatment differences were analysed for major adverse cardiovascular events (MACE), all-cause mortality, severe hypoglycaemia and serious adverse events (SAEs). Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1111/dom.13699
Publisher Site
http://dx.doi.org/10.1111/dom.13699DOI Listing
March 2019
11 Reads

Noninvasive Prenatal Testing for Trisomies 21, 18, and 13, Sex Chromosome Aneuploidies, and Microdeletions: A Health Technology Assessment.

Authors:

Ont Health Technol Assess Ser 2019 19;19(4):1-166. Epub 2019 Feb 19.

Background: Pregnant people have a risk of carrying a fetus affected by a chromosomal anomaly. Prenatal screening is offered to pregnant people to assess their risk. Noninvasive prenatal testing (NIPT) has been introduced clinically, which uses the presence of circulating cell-free fetal DNA in the maternal blood to quantify the risk of a chromosomal anomaly. Read More

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6395059PMC

Past and future spread of the arbovirus vectors Aedes aegypti and Aedes albopictus.

Nat Microbiol 2019 May 4;4(5):854-863. Epub 2019 Mar 4.

School of BioSciences, University of Melbourne, Parkville, Victoria, Australia.

The global population at risk from mosquito-borne diseases-including dengue, yellow fever, chikungunya and Zika-is expanding in concert with changes in the distribution of two key vectors: Aedes aegypti and Aedes albopictus. The distribution of these species is largely driven by both human movement and the presence of suitable climate. Using statistical mapping techniques, we show that human movement patterns explain the spread of both species in Europe and the United States following their introduction. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41564-019-0376-yDOI Listing
May 2019
10 Reads

A spatial assessment of Nipah virus transmission in Thailand pig farms using multi-criteria decision analysis.

BMC Vet Res 2019 Mar 4;15(1):73. Epub 2019 Mar 4.

Spatial epidemiology Lab. (SpELL), University of Brussels, Brussels, Belgium.

Background: Thailand's Central Plain is identified as a contact zone between pigs and flying foxes, representing a potential zoonotic risk. Nipah virus (NiV) has been reported in flying foxes in Thailand, but it has never been found in pigs or humans. An assessment of the suitability of NiV transmission at the spatial and farm level would be useful for disease surveillance and prevention. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12917-019-1815-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6399983PMC
March 2019
3 Reads

Discovery and Characterization of Bukakata orbivirus (), a Novel Virus from a Ugandan Bat.

Viruses 2019 Mar 2;11(3). Epub 2019 Mar 2.

Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, CO 80523, USA.

While serological and virological evidence documents the exposure of bats to medically-important arboviruses, their role as reservoirs or amplifying hosts is less well-characterized. We describe a novel orbivirus () isolated from an Egyptian fruit bat () trapped in 2013 in Uganda and named Bukakata orbivirus. This is the fifth orbivirus isolated from a bat, however genetic information had previously only been available for one bat-associated orbivirus. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/v11030209DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6466370PMC
March 2019
1 Read
3.279 Impact Factor

Physician agreement on the diagnosis of sepsis in the intensive care unit: estimation of concordance and analysis of underlying factors in a multicenter cohort.

J Intensive Care 2019 21;7:13. Epub 2019 Feb 21.

Immunexpress Inc, 425 Pontius Avenue North, Suite 430, Seattle, WA 98109 USA.

Background: Differentiating sepsis from the systemic inflammatory response syndrome (SIRS) in critical care patients is challenging, especially before serious organ damage is evident, and with variable clinical presentations of patients and variable training and experience of attending physicians. Our objective was to describe and quantify physician agreement in diagnosing SIRS or sepsis in critical care patients as a function of available clinical information, infection site, and hospital setting.

Methods: We conducted a post hoc analysis of previously collected data from a prospective, observational trial ( = 249 subjects) in intensive care units at seven US hospitals, in which physicians at different stages of patient care were asked to make diagnostic calls of either SIRS, sepsis, or indeterminate, based on varying amounts of available clinical information (clinicaltrials. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s40560-019-0368-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6383290PMC
February 2019
1 Read

Significance of *28 Genotype in Patients with Advanced Liver Injury Caused By Chronic Hepatitis C.

J Med Biochem 2019 Mar 1;38(1):45-52. Epub 2019 Mar 1.

Clinic for Infectious and Tropical Diseases, Clinical Centre of Serbia, Belgrade, Serbia.

Background: Chronic hepatitis C (CHC) is a significant cause of liver related morbidity and mortality worldwide. The role of genetics in the host response to hepatitis C virus is not elucidated. Genetic variations in gene are the most common cause of hereditary unconjugated hyperbilirubinemia-Gilbert syndrome. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2478/jomb-2018-0015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6298452PMC
March 2019
1 Read

Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing.

Authors:
Brian W Kunkle Benjamin Grenier-Boley Rebecca Sims Joshua C Bis Vincent Damotte Adam C Naj Anne Boland Maria Vronskaya Sven J van der Lee Alexandre Amlie-Wolf Céline Bellenguez Aura Frizatti Vincent Chouraki Eden R Martin Kristel Sleegers Nandini Badarinarayan Johanna Jakobsdottir Kara L Hamilton-Nelson Sonia Moreno-Grau Robert Olaso Rachel Raybould Yuning Chen Amanda B Kuzma Mikko Hiltunen Taniesha Morgan Shahzad Ahmad Badri N Vardarajan Jacques Epelbaum Per Hoffmann Merce Boada Gary W Beecham Jean-Guillaume Garnier Denise Harold Annette L Fitzpatrick Otto Valladares Marie-Laure Moutet Amy Gerrish Albert V Smith Liming Qu Delphine Bacq Nicola Denning Xueqiu Jian Yi Zhao Maria Del Zompo Nick C Fox Seung-Hoan Choi Ignacio Mateo Joseph T Hughes Hieab H Adams John Malamon Florentino Sanchez-Garcia Yogen Patel Jennifer A Brody Beth A Dombroski Maria Candida Deniz Naranjo Makrina Daniilidou Gudny Eiriksdottir Shubhabrata Mukherjee David Wallon James Uphill Thor Aspelund Laura B Cantwell Fabienne Garzia Daniela Galimberti Edith Hofer Mariusz Butkiewicz Bertrand Fin Elio Scarpini Chloe Sarnowski Will S Bush Stéphane Meslage Johannes Kornhuber Charles C White Yuenjoo Song Robert C Barber Sebastiaan Engelborghs Sabrina Sordon Dina Voijnovic Perrie M Adams Rik Vandenberghe Manuel Mayhaus L Adrienne Cupples Marilyn S Albert Peter P De Deyn Wei Gu Jayanadra J Himali Duane Beekly Alessio Squassina Annette M Hartmann Adelina Orellana Deborah Blacker Eloy Rodriguez-Rodriguez Simon Lovestone Melissa E Garcia Rachelle S Doody Carmen Munoz-Fernadez Rebecca Sussams Honghuang Lin Thomas J Fairchild Yolanda A Benito Clive Holmes Hata Karamujić-Čomić Matthew P Frosch Hakan Thonberg Wolfgang Maier Gena Roschupkin Bernardino Ghetti Vilmantas Giedraitis Amit Kawalia Shuo Li Ryan M Huebinger Lena Kilander Susanne Moebus Isabel Hernández M Ilyas Kamboh RoseMarie Brundin James Turton Qiong Yang Mindy J Katz Letizia Concari Jenny Lord Alexa S Beiser C Dirk Keene Seppo Helisalmi Iwona Kloszewska Walter A Kukull Anne Maria Koivisto Aoibhinn Lynch Lluís Tarraga Eric B Larson Annakaisa Haapasalo Brian Lawlor Thomas H Mosley Richard B Lipton Vincenzo Solfrizzi Michael Gill W T Longstreth Thomas J Montine Vincenza Frisardi Monica Diez-Fairen Fernando Rivadeneira Ronald C Petersen Vincent Deramecourt Ignacio Alvarez Francesca Salani Antonio Ciaramella Eric Boerwinkle Eric M Reiman Nathalie Fievet Jerome I Rotter Joan S Reisch Olivier Hanon Chiara Cupidi A G Andre Uitterlinden Donald R Royall Carole Dufouil Raffaele Giovanni Maletta Itziar de Rojas Mary Sano Alexis Brice Roberta Cecchetti Peter St George-Hyslop Karen Ritchie Magda Tsolaki Debby W Tsuang Bruno Dubois David Craig Chuang-Kuo Wu Hilkka Soininen Despoina Avramidou Roger L Albin Laura Fratiglioni Antonia Germanou Liana G Apostolova Lina Keller Maria Koutroumani Steven E Arnold Francesco Panza Olymbia Gkatzima Sanjay Asthana Didier Hannequin Patrice Whitehead Craig S Atwood Paolo Caffarra Harald Hampel Inés Quintela Ángel Carracedo Lars Lannfelt David C Rubinsztein Lisa L Barnes Florence Pasquier Lutz Frölich Sandra Barral Bernadette McGuinness Thomas G Beach Janet A Johnston James T Becker Peter Passmore Eileen H Bigio Jonathan M Schott Thomas D Bird Jason D Warren Bradley F Boeve Michelle K Lupton James D Bowen Petra Proitsi Adam Boxer John F Powell James R Burke John S K Kauwe Jeffrey M Burns Michelangelo Mancuso Joseph D Buxbaum Ubaldo Bonuccelli Nigel J Cairns Andrew McQuillin Chuanhai Cao Gill Livingston Chris S Carlson Nicholas J Bass Cynthia M Carlsson John Hardy Regina M Carney Jose Bras Minerva M Carrasquillo Rita Guerreiro Mariet Allen Helena C Chui Elizabeth Fisher Carlo Masullo Elizabeth A Crocco Charles DeCarli Gina Bisceglio Malcolm Dick Li Ma Ranjan Duara Neill R Graff-Radford Denis A Evans Angela Hodges Kelley M Faber Martin Scherer Kenneth B Fallon Matthias Riemenschneider David W Fardo Reinhard Heun Martin R Farlow Heike Kölsch Steven Ferris Markus Leber Tatiana M Foroud Isabella Heuser Douglas R Galasko Ina Giegling Marla Gearing Michael Hüll Daniel H Geschwind John R Gilbert John Morris Robert C Green Kevin Mayo John H Growdon Thomas Feulner Ronald L Hamilton Lindy E Harrell Dmitriy Drichel Lawrence S Honig Thomas D Cushion Matthew J Huentelman Paul Hollingworth Christine M Hulette Bradley T Hyman Rachel Marshall Gail P Jarvik Alun Meggy Erin Abner Georgina E Menzies Lee-Way Jin Ganna Leonenko Luis M Real Gyungah R Jun Clinton T Baldwin Detelina Grozeva Anna Karydas Giancarlo Russo Jeffrey A Kaye Ronald Kim Frank Jessen Neil W Kowall Bruno Vellas Joel H Kramer Emma Vardy Frank M LaFerla Karl-Heinz Jöckel James J Lah Martin Dichgans James B Leverenz David Mann Allan I Levey Stuart Pickering-Brown Andrew P Lieberman Norman Klopp Kathryn L Lunetta H-Erich Wichmann Constantine G Lyketsos Kevin Morgan Daniel C Marson Kristelle Brown Frank Martiniuk Christopher Medway Deborah C Mash Markus M Nöthen Eliezer Masliah Nigel M Hooper Wayne C McCormick Antonio Daniele Susan M McCurry Anthony Bayer Andrew N McDavid John Gallacher Ann C McKee Hendrik van den Bussche Marsel Mesulam Carol Brayne Bruce L Miller Steffi Riedel-Heller Carol A Miller Joshua W Miller Ammar Al-Chalabi John C Morris Christopher E Shaw Amanda J Myers Jens Wiltfang Sid O'Bryant John M Olichney Victoria Alvarez Joseph E Parisi Andrew B Singleton Henry L Paulson John Collinge William R Perry Simon Mead Elaine Peskind David H Cribbs Martin Rossor Aimee Pierce Natalie S Ryan Wayne W Poon Benedetta Nacmias Huntington Potter Sandro Sorbi Joseph F Quinn Eleonora Sacchinelli Ashok Raj Gianfranco Spalletta Murray Raskind Carlo Caltagirone Paola Bossù Maria Donata Orfei Barry Reisberg Robert Clarke Christiane Reitz A David Smith John M Ringman Donald Warden Erik D Roberson Gordon Wilcock Ekaterina Rogaeva Amalia Cecilia Bruni Howard J Rosen Maura Gallo Roger N Rosenberg Yoav Ben-Shlomo Mark A Sager Patrizia Mecocci Andrew J Saykin Pau Pastor Michael L Cuccaro Jeffery M Vance Julie A Schneider Lori S Schneider Susan Slifer William W Seeley Amanda G Smith Joshua A Sonnen Salvatore Spina Robert A Stern Russell H Swerdlow Mitchell Tang Rudolph E Tanzi John Q Trojanowski Juan C Troncoso Vivianna M Van Deerlin Linda J Van Eldik Harry V Vinters Jean Paul Vonsattel Sandra Weintraub Kathleen A Welsh-Bohmer Kirk C Wilhelmsen Jennifer Williamson Thomas S Wingo Randall L Woltjer Clinton B Wright Chang-En Yu Lei Yu Yasaman Saba Alberto Pilotto Maria J Bullido Oliver Peters Paul K Crane David Bennett Paola Bosco Eliecer Coto Virginia Boccardi Phil L De Jager Alberto Lleo Nick Warner Oscar L Lopez Martin Ingelsson Panagiotis Deloukas Carlos Cruchaga Caroline Graff Rhian Gwilliam Myriam Fornage Alison M Goate Pascual Sanchez-Juan Patrick G Kehoe Najaf Amin Nilifur Ertekin-Taner Claudine Berr Stéphanie Debette Seth Love Lenore J Launer Steven G Younkin Jean-Francois Dartigues Chris Corcoran M Arfan Ikram Dennis W Dickson Gael Nicolas Dominique Campion JoAnn Tschanz Helena Schmidt Hakon Hakonarson Jordi Clarimon Ron Munger Reinhold Schmidt Lindsay A Farrer Christine Van Broeckhoven Michael C O'Donovan Anita L DeStefano Lesley Jones Jonathan L Haines Jean-Francois Deleuze Michael J Owen Vilmundur Gudnason Richard Mayeux Valentina Escott-Price Bruce M Psaty Alfredo Ramirez Li-San Wang Agustin Ruiz Cornelia M van Duijn Peter A Holmans Sudha Seshadri Julie Williams Phillippe Amouyel Gerard D Schellenberg Jean-Charles Lambert Margaret A Pericak-Vance

Nat Genet 2019 03 28;51(3):414-430. Epub 2019 Feb 28.

John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA.

Risk for late-onset Alzheimer's disease (LOAD), the most prevalent dementia, is partially driven by genetics. To identify LOAD risk loci, we performed a large genome-wide association meta-analysis of clinically diagnosed LOAD (94,437 individuals). We confirm 20 previous LOAD risk loci and identify five new genome-wide loci (IQCK, ACE, ADAM10, ADAMTS1, and WWOX), two of which (ADAM10, ACE) were identified in a recent genome-wide association (GWAS)-by-familial-proxy of Alzheimer's or dementia. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41588-019-0358-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6463297PMC
March 2019
15 Reads
29.352 Impact Factor

Interrogating the Genetic Determinants of Tourette's Syndrome and Other Tic Disorders Through Genome-Wide Association Studies.

Am J Psychiatry 2019 Mar;176(3):217-227

The Psychiatric and Neurodevelopmental Genetics Unit, Center for Genomic Medicine, Department of Psychiatry, Massachusetts General Hospital, Boston (Yu, Illmann, Osiecki, Smoller, Pauls, Neale, Scharf); the Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, Mass. (Yu, Neale, Scharf); the Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, University of California, Los Angeles (Sul, Huang, Zelaya, Ophoff, Freimer, Coppola); the Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles (Sul, Huang, Zelaya, Freimer, Coppola); the Department of Molecular Biology and Genetics, Democritus University of Thrace, Xanthi, Greece (Tsetsos); the Department of Biological Sciences, Purdue University, West Lafayette, Ind. (Tsetsos, Paschou); deCODE Genetics/Amgen, Reykjavik, Iceland (Nawaz, H. Stefansson, K. Stefansson); the Bioinformatics Interdepartmental Program, University of California, Los Angeles (Huang, Zelaya); the Department of Psychiatry, University of California, San Francisco (Darrow); the Department of Psychiatry, UCSF Weill Institute for Neurosciences, University of California, San Francisco (Hirschtritt, Willsey); the Department of Psychiatry, Massachusetts General Hospital, Boston (Greenberg, Roffman, Buckner); the Clinic of Psychiatry, Social Psychiatry, and Psychotherapy, Hannover Medical School, Hannover, Germany (Muller-Vahl); the Institute of Human Genetics, Hannover Medical School, Hannover, Germany (Stuhrmann); McGill University Health Center, University of Montreal, McGill University Health Centre, Montreal (Dion); the Montreal Neurological Institute, Department of Neurology and Neurosurgery, McGill University, Montreal (Rouleau); the Department of Psychiatry and Psychotherapy, Medical University Vienna, Vienna (Aschauer, Stamenkovic); Biopsychosocial Corporation, Vienna (Aschauer, Schlögelhofer); University Health Network, Youthdale Treatment Centres, and University of Toronto, Toronto (Sandor); the Krembil Research Institute, University Health Network, Hospital for Sick Children, and University of Toronto, Toronto (Barr); Johns Hopkins University School of Medicine, Baltimore (Grados, Singer); the Institute of Human Genetics, University Hospital Bonn, University of Bonn Medical School, Bonn, Germany (Nöthen); the Department of Child and Adolescent Psychiatry, Psychosomatics, and Psychotherapy, University Hospital Essen, University of Duisburg-Essen, Essen, Germany (Hebebrand, Hinney); the Yale Child Study Center and the Department of Psychiatry, Yale University School of Medicine, New Haven, Conn. (King, Fernandez); the Institute of Medical Chemistry, Molecular Biology, and Pathobiochemistry, Semmelweis University, Budapest, Hungary (Barta); Vadaskert Child and Adolescent Psychiatric Hospital, Budapest, Hungary (Tarnok, Nagy); the Institute of Human Genetics, University Hospital Essen, University Duisburg-Essen, Essen, Germany (Depienne); Sorbonne Universités, UPMC Université Paris 06, UMR S 1127, CNRS UMR 7225, ICM, Paris (Depienne, Worbe, Hartmann); French Reference Centre for Gilles de la Tourette Syndrome, Groupe Hospitalier Pitié-Salpêtrière, Paris (Worbe, Hartmann); Assistance Publique-Hôpitaux de Paris, Department of Neurology, Groupe Hospitalier Pitié-Salpêtrière, Paris (Worbe, Hartmann); Zucker School of Medicine at Hofstra/Northwell, Hempstead, New York (Budman); Child Neuropsychiatry, Department of Clinical and Experimental Medicine, University of Catania, Catania, Italy (Rizzo); the Stanley Institute for Cognitive Genomics, Cold Spring Harbor Laboratory, Cold Spring Harbor, New York (Lyon); the Department of Psychiatry, University of Utah, Salt Lake City (McMahon); Children's Mercy Hospital, Kansas City, Mo. (Batterson); the Department of Psychiatry, University Medical Center Groningen and Rijksuniversity Groningen, and Drenthe Mental Health Center, Groningen, the Netherlands (Cath); the Department of Neurology, Fixel Center for Neurological Diseases, McKnight Brain Institute, University of Florida, Gainesville (Malaty, Okun); Pennsylvania State University College of Medicine, Hershey (Berlin); Marquette University and University of Wisconsin-Milwaukee, Milwaukee (Woods); Tripler Army Medical Center and University of Hawaii John A. Burns School of Medicine, Honolulu (Lee); Parkinson's Disease Center and Movement Disorders Clinic, Department of Neurology, Baylor College of Medicine, Houston (Jankovic); the Division of Psychiatry, Department of Neuropsychiatry, University College London (Robertson); the Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati (Gilbert); Children's Hospital of Philadelphia, Philadelphia (Brown); the Department of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine, Miami (Coffey); the Department of Child and Adolescent Psychiatry, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands (Dietrich, Hoekstra); University of Iowa Carver College of Medicine, Iowa City (Kuperman); the Department of Pediatrics, University of Washington, Seattle (Zinner); the Department of Pediatrics, Landspitalinn University Hospital, Reykjavik, Iceland (Luðvigsson, Thorarensen); the Faculty of Medicine, University of Iceland, Reykjavík, Iceland (Sæmundsen, Stefansson); the State Diagnostic and Counselling Centre, Kópavogur, Iceland (Sæmundsen); the Department of Genetics and the Department of Medicine, Albert Einstein College of Medicine, Bronx, New York (Atzmon, Barzilai); the Department of Human Biology, Haifa University, Haifa, Israel (Atzmon); the Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany (Wagner); the Department of Psychiatry and Psychotherapy, University of Tübingen, Tübingen, Germany (Moessner); SUNY Downstate Medical Center Brooklyn, New York (C.M. Pato, M.T. Pato, Knowles); the Athinoula A. Martinos Center for Biomedical Research, Department of Radiology, Massachusetts General Hospital, Charlestown (Roffman, Buckner); the Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston (Smoller); the Center for Brain Science and Department of Psychology, Harvard University, Cambridge, Mass. (Buckner); the Institute for Neurodegenerative Diseases, UCSF Weill Institute for Neurosciences, University of California San Francisco, San Francisco (Willsey); the Department of Genetics and the Human Genetics Institute of New Jersey, Rutgers, the State University of New Jersey, Piscataway (Tischfield, Heiman); the Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, VU University Amsterdam, Amsterdam (Posthuma); the Division of Genetic Medicine, Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, Tenn. (Cox, Davis); the Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, Boston (Neale); the Department of Psychiatry, Genetics Institute, University of Florida, Gainesville (Mathews); and the Department of Neurology, Brigham and Women's Hospital, and the Department of Neurology, Massachusetts General Hospital, Boston (Scharf).

Objective:: Tourette's syndrome is polygenic and highly heritable. Genome-wide association study (GWAS) approaches are useful for interrogating the genetic architecture and determinants of Tourette's syndrome and other tic disorders. The authors conducted a GWAS meta-analysis and probed aggregated Tourette's syndrome polygenic risk to test whether Tourette's and related tic disorders have an underlying shared genetic etiology and whether Tourette's polygenic risk scores correlate with worst-ever tic severity and may represent a potential predictor of disease severity. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1176/appi.ajp.2018.18070857DOI Listing
March 2019
286 Reads
12.295 Impact Factor

Clinician perceptions of respiratory infection risk; a rationale for research into mask use in routine practice.

Infect Dis Health 2019 Feb 21. Epub 2019 Feb 21.

Centre for Infectious Diseases and Microbiology, Westmead Institute for Medical Research, 176 Hawkesbury Rd, Westmead, NSW 2145, Australia; Marie Bashir Institute for Infectious Diseases and Biosecurity, University of Sydney, Camperdown, NSW 2050, Australia. Electronic address:

Outbreaks of emerging and re-emerging infectious diseases are global threats to society. Planning for, and responses to, such events must include healthcare and other measures based on current evidence. An important area of infection prevention and control (IPC) is the optimal use of personal protective equipment (PPE) by healthcare workers (HCWs), including masks for protection against respiratory pathogens. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.idh.2019.01.003DOI Listing
February 2019

Enhanced IL-1β production is mediated by a TLR2-MYD88-NLRP3 signaling axis during coinfection with influenza A virus and Streptococcus pneumoniae.

PLoS One 2019 22;14(2):e0212236. Epub 2019 Feb 22.

Department of Biology, Missouri State University, Springfield, Missouri, United States of America.

Viral-bacterial coinfections, such as with influenza A virus and Streptococcus pneumoniae (S.p.), are known to cause severe pneumonia. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212236PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6386446PMC
February 2019
2 Reads

Identifying Novel Sepsis Subphenotypes Using Temperature Trajectories.

Am J Respir Crit Care Med 2019 Feb 21. Epub 2019 Feb 21.

University of Chicago, Pulmonary and Critical Care, Chicago, Illinois, United States.

Rationale: Sepsis is a heterogeneous syndrome, and identifying clinically relevant subphenotypes is essential.

Objectives: To identify novel subphenotypes in hospitalized patients with infection using longitudinal temperature trajectories.

Methods: In the model development cohort, inpatient admissions meeting criteria for infection in the emergency department and receiving antibiotics within 24 hours of presentation were included. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1164/rccm.201806-1197OCDOI Listing
February 2019
1 Read

Integrated systems approach defines the antiviral pathways conferring protection by the RV144 HIV vaccine.

Nat Commun 2019 02 20;10(1):863. Epub 2019 Feb 20.

Department of Pathology, Case Western Reserve University, Cleveland, OH, 44106, USA.

The RV144 vaccine trial showed reduced risk of HIV-1 acquisition by 31.2%, although mechanisms that led to protection remain poorly understood. Here we identify transcriptional correlates for reduced HIV-1 acquisition after vaccination. Read More

View Article

Download full-text PDF

Source
http://www.nature.com/articles/s41467-019-08854-2
Publisher Site
http://dx.doi.org/10.1038/s41467-019-08854-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6382801PMC
February 2019
5 Reads

Radiation dose mapping and anastomotic complications after trimodality therapy for esophageal cancers.

Clin Transl Radiat Oncol 2019 Feb 24;15:76-82. Epub 2019 Jan 24.

Division of Radiation Oncology, University of Ottawa. 501 Smyth Road, Ottawa, Ontario K1H 8L6, Canada.

Background And Purpose: There is conflicting evidence with respect to the correlation between neoadjuvant chemoradiation and anastomotic complications following trimodality therapy in patients with esophageal cancer. We aimed to analyze the relationship between their dosimetry and any resulting anastomotic complications.

Materials And Methods: The medical records of 51 consecutive patients who underwent trimodality therapy between 2007 and 2014 were retrospectively reviewed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ctro.2018.12.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365800PMC
February 2019
3 Reads

Symposium review: Mechanisms of disruption of fertility by infectious diseases of the reproductive tract.

Authors:
Robert O Gilbert

J Dairy Sci 2019 Apr 14;102(4):3754-3765. Epub 2019 Feb 14.

Ross University School of Veterinary Medicine, PO Box 334, Basseterre, St. Kitts and Nevis, West Indies. Electronic address:

Diseases of postpartum dairy cows impair reproductive processes, resulting in prolonged anestrus, reduced conception, and increased pregnancy attrition, regardless of whether the initial disease precedes insemination (even by many weeks), occurs close to insemination, or follows fertilization. Bacteria and their products activate pattern recognition receptors that respond to pathogen-associated molecular patterns (PAMP). These receptors include toll-like receptors (TLR), nucleotide-binding oligomerization domain (NOD)-like receptors and others, and their activation culminates in upregulation of proinflammatory cytokines such as IL-1β, IL-18, and tumor necrosis factor-α. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3168/jds.2018-15602DOI Listing

Stifle joint osteoarthritis at the time of diagnosis of cranial cruciate ligament injury is higher in Boxers and in dogs weighing more than 35 kilograms.

Vet Radiol Ultrasound 2019 Feb 15. Epub 2019 Feb 15.

Department of Population Health and Pathobiology, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, 27607.

Osteoarthritis is a ubiquitous disease in dogs. The purpose of this retrospective study was to characterize the severity and distribution of osteoarthritis (OA) within the joint and to identify differences among dog breeds in the severity of OA in the cranial cruciate ligament (CCL)-deficient stifle joint. Radiographs of 240 stifles from 51 Boxers, 66 German Shepherds, 100 Labrador Retrievers, and 23 Siberian Huskies with confirmed CCL rupture were included. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/vru.12718DOI Listing
February 2019
2 Reads

in individuals at risk for rheumatoid arthritis.

Ann Rheum Dis 2019 May 13;78(5):590-593. Epub 2019 Feb 13.

Department of Microbial Immune Regulation, Helmholtz Centre for Infection Research, Braunschweig, Germany

Objectives: Rheumatoid arthritis (RA) has been associated with a relative expansion of faecal Prevotellaceae. To determine the microbiome composition and prevalence of spp. in a group of individuals at increased risk for RA, but prior to the development of the disease. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/annrheumdis-2018-214514DOI Listing
May 2019
3 Reads

Infective Endocarditis in Injection Drug Users: A Recurrent Disease.

J Am Coll Cardiol 2019 Feb;73(5):571-572

Aix-Marseille Université, Institut de Recherche pour le Developpement, Assistance Publique Hopitaux de Marseille, Microbes Evolution Phylogeny and Infection, Institut Hospitalo-Universitaire Méditerranée Infection, Marseille, France.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jacc.2018.10.081DOI Listing
February 2019
1 Read

Absence of adaptive evolution is the main barrier against influenza emergence in horses in Asia despite frequent virus interspecies transmission from wild birds.

PLoS Pathog 2019 02 7;15(2):e1007531. Epub 2019 Feb 7.

MRC-University of Glasgow Centre for Virus Research, Glasgow, United Kingdom.

Virus ecology and evolution play a central role in disease emergence. However, their relative roles will vary depending on the viruses and ecosystems involved. We combined field studies, phylogenetics and experimental infections to document with unprecedented detail the stages that precede initial outbreaks during viral emergence in nature. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1371/journal.ppat.1007531DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366691PMC
February 2019
2 Reads

Comparison of Loop-Mediated Isothermal Amplification and Real-Time PCR Assays for Detection of Strongyloides Larvae in Different Specimen Matrices.

J Clin Microbiol 2019 Apr 28;57(4). Epub 2019 Mar 28.

Parasitology Laboratory, Centre for Infectious Diseases and Microbiology, Institute for Clinical Pathology and Medical Research-New South Wales Health Pathology, Westmead Hospital, Westmead, New South Wales, Australia.

can cause disease that ranges from asymptomatic chronic infection to fatal hyperinfection. Diagnosis from stool can be challenging because the most sensitive conventional tests require live larvae to be effective and there can be low larval output in chronic infection. Nucleic acid amplification tests (NAAT) have been developed to complement existing diagnostic methods. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/JCM.01173-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440779PMC
April 2019
3 Reads