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Synaptic potentiation and rapid antidepressant response to ketamine in treatment-resistant major depression: A replication study.

Psychiatry Res Neuroimaging 2018 Sep 12;283:64-66. Epub 2018 Sep 12.

Experimental Therapeutics and Pathophysiology Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, USA.

Preclinical and clinical evidence has demonstrated that ketamine has rapid antidepressant effects. Studies using pre-treatment with an AMPA inhibitor suggest that enhancing AMPA throughput is crucial to ketamine's effects, including increases in both basal and evoked gamma power. This study sought to replicate previous findings of increased gamma response to a somatosensory stimulus at 230 min and Day 1 in ketamine responders versus non-responders in 31 depressed subjects and 25 healthy controls. Read More

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September 2018

Evidence for the Associated Production of a Single Top Quark and a Photon in Proton-Proton Collisions at sqrt[s]=13  TeV.

Authors:
A M Sirunyan A Tumasyan W Adam F Ambrogi E Asilar T Bergauer J Brandstetter M Dragicevic J Erö A Escalante Del Valle M Flechl R Frühwirth V M Ghete J Hrubec M Jeitler N Krammer I Krätschmer D Liko T Madlener I Mikulec N Rad H Rohringer J Schieck R Schöfbeck M Spanring D Spitzbart A Taurok W Waltenberger J Wittmann C-E Wulz M Zarucki V Chekhovsky V Mossolov J Suarez Gonzalez E A De Wolf D Di Croce X Janssen J Lauwers M Pieters H Van Haevermaet P Van Mechelen N Van Remortel S Abu Zeid F Blekman J D'Hondt I De Bruyn J De Clercq K Deroover G Flouris D Lontkovskyi S Lowette I Marchesini S Moortgat L Moreels Q Python K Skovpen S Tavernier W Van Doninck P Van Mulders I Van Parijs D Beghin B Bilin H Brun B Clerbaux G De Lentdecker H Delannoy B Dorney G Fasanella L Favart R Goldouzian A Grebenyuk A K Kalsi T Lenzi J Luetic N Postiau E Starling L Thomas C Vander Velde P Vanlaer D Vannerom Q Wang T Cornelis D Dobur A Fagot M Gul I Khvastunov D Poyraz C Roskas D Trocino M Tytgat W Verbeke B Vermassen M Vit N Zaganidis H Bakhshiansohi O Bondu S Brochet G Bruno C Caputo P David C Delaere M Delcourt B Francois A Giammanco G Krintiras V Lemaitre A Magitteri A Mertens M Musich K Piotrzkowski A Saggio M Vidal Marono S Wertz J Zobec F L Alves G A Alves M Correa Martins Junior G Correia Silva C Hensel A Moraes M E Pol P Rebello Teles E Belchior Batista Das Chagas W Carvalho J Chinellato E Coelho E M Da Costa G G Da Silveira D De Jesus Damiao C De Oliveira Martins S Fonseca De Souza H Malbouisson D Matos Figueiredo M Melo De Almeida C Mora Herrera L Mundim H Nogima W L Prado Da Silva L J Sanchez Rosas A Santoro A Sznajder M Thiel E J Tonelli Manganote F Torres Da Silva De Araujo A Vilela Pereira S Ahuja C A Bernardes L Calligaris T R Fernandez Perez Tomei E M Gregores P G Mercadante S F Novaes Sandra S Padula A Aleksandrov R Hadjiiska P Iaydjiev A Marinov M Misheva M Rodozov M Shopova G Sultanov A Dimitrov L Litov B Pavlov P Petkov W Fang X Gao L Yuan M Ahmad J G Bian G M Chen H S Chen M Chen Y Chen C H Jiang D Leggat H Liao Z Liu F Romeo S M Shaheen A Spiezia J Tao Z Wang E Yazgan H Zhang S Zhang J Zhao Y Ban G Chen A Levin J Li L Li Q Li Y Mao S J Qian D Wang Z Xu Y Wang C Avila A Cabrera C A Carrillo Montoya L F Chaparro Sierra C Florez C F González Hernández M A Segura Delgado B Courbon N Godinovic D Lelas I Puljak T Sculac Z Antunovic M Kovac V Brigljevic D Ferencek K Kadija B Mesic A Starodumov T Susa M W Ather A Attikis M Kolosova G Mavromanolakis J Mousa C Nicolaou F Ptochos P A Razis H Rykaczewski M Finger M Finger E Ayala E Carrera Jarrin H Abdalla A A Abdelalim E Salama S Bhowmik A Carvalho Antunes De Oliveira R K Dewanjee K Ehataht M Kadastik M Raidal C Veelken P Eerola H Kirschenmann J Pekkanen M Voutilainen J Havukainen J K Heikkilä T Järvinen V Karimäki R Kinnunen T Lampén K Lassila-Perini S Laurila S Lehti T Lindén P Luukka T Mäenpää H Siikonen E Tuominen J Tuominiemi T Tuuva M Besancon F Couderc M Dejardin D Denegri J L Faure F Ferri S Ganjour A Givernaud P Gras G Hamel de Monchenault P Jarry C Leloup E Locci J Malcles G Negro J Rander A Rosowsky M Ö Sahin M Titov A Abdulsalam C Amendola I Antropov F Beaudette P Busson C Charlot R Granier de Cassagnac I Kucher A Lobanov J Martin Blanco C Martin Perez M Nguyen C Ochando G Ortona P Paganini P Pigard J Rembser R Salerno J B Sauvan Y Sirois A G Stahl Leiton A Zabi A Zghiche J-L Agram J Andrea D Bloch J-M Brom E C Chabert V Cherepanov C Collard E Conte J-C Fontaine D Gelé U Goerlach M Jansová A-C Le Bihan N Tonon P Van Hove S Gadrat S Beauceron C Bernet G Boudoul N Chanon R Chierici D Contardo P Depasse H El Mamouni J Fay L Finco S Gascon M Gouzevitch G Grenier B Ille F Lagarde I B Laktineh H Lattaud M Lethuillier L Mirabito S Perries A Popov V Sordini G Touquet M Vander Donckt S Viret A Khvedelidze Z Tsamalaidze C Autermann L Feld M K Kiesel K Klein M Lipinski M Preuten M P Rauch C Schomakers J Schulz M Teroerde B Wittmer V Zhukov A Albert D Duchardt M Endres M Erdmann S Erdweg T Esch R Fischer S Ghosh A Güth T Hebbeker C Heidemann K Hoepfner H Keller L Mastrolorenzo M Merschmeyer A Meyer P Millet S Mukherjee T Pook M Radziej H Reithler M Rieger A Schmidt D Teyssier S Thüer G Flügge O Hlushchenko T Kress A Künsken T Müller A Nehrkorn A Nowack C Pistone O Pooth D Roy H Sert A Stahl M Aldaya Martin T Arndt C Asawatangtrakuldee I Babounikau K Beernaert O Behnke U Behrens A Bermúdez Martínez D Bertsche A A Bin Anuar K Borras V Botta A Campbell P Connor C Contreras-Campana V Danilov A De Wit M M Defranchis C Diez Pardos D Domínguez Damiani G Eckerlin T Eichhorn A Elwood E Eren E Gallo A Geiser A Grohsjean M Guthoff M Haranko A Harb J Hauk H Jung M Kasemann J Keaveney C Kleinwort J Knolle D Krücker W Lange A Lelek T Lenz J Leonard K Lipka W Lohmann R Mankel I-A Melzer-Pellmann A B Meyer M Meyer M Missiroli G Mittag J Mnich V Myronenko S K Pflitsch D Pitzl A Raspereza M Savitskyi P Saxena P Schütze C Schwanenberger R Shevchenko A Singh H Tholen O Turkot A Vagnerini G P Van Onsem R Walsh Y Wen K Wichmann C Wissing O Zenaiev R Aggleton S Bein L Benato A Benecke V Blobel T Dreyer E Garutti D Gonzalez P Gunnellini J Haller A Hinzmann A Karavdina G Kasieczka R Klanner R Kogler N Kovalchuk S Kurz V Kutzner J Lange D Marconi J Multhaup M Niedziela C E N Niemeyer D Nowatschin A Perieanu A Reimers O Rieger C Scharf P Schleper S Schumann J Schwandt J Sonneveld H Stadie G Steinbrück F M Stober M Stöver A Vanhoefer B Vormwald I Zoi M Akbiyik C Barth M Baselga S Baur E Butz R Caspart T Chwalek F Colombo W De Boer A Dierlamm K El Morabit N Faltermann B Freund M Giffels M A Harrendorf F Hartmann S M Heindl U Husemann F Kassel I Katkov S Kudella H Mildner S Mitra M U Mozer Th Müller M Plagge G Quast K Rabbertz M Schröder I Shvetsov G Sieber H J Simonis R Ulrich S Wayand M Weber T Weiler S Williamson C Wöhrmann R Wolf G Anagnostou G Daskalakis T Geralis A Kyriakis D Loukas G Paspalaki I Topsis-Giotis G Karathanasis S Kesisoglou P Kontaxakis A Panagiotou I Papavergou N Saoulidou E Tziaferi K Vellidis K Kousouris I Papakrivopoulos G Tsipolitis I Evangelou C Foudas P Gianneios P Katsoulis P Kokkas S Mallios N Manthos I Papadopoulos E Paradas J Strologas F A Triantis D Tsitsonis M Bartók M Csanad N Filipovic P Major M I Nagy G Pasztor O Surányi G I Veres G Bencze C Hajdu D Horvath Á Hunyadi F Sikler T Á Vámi V Veszpremi G Vesztergombi N Beni S Czellar J Karancsi A Makovec J Molnar Z Szillasi P Raics Z L Trocsanyi B Ujvari S Choudhury J R Komaragiri P C Tiwari S Bahinipati C Kar P Mal K Mandal A Nayak D K Sahoo S K Swain S Bansal S B Beri V Bhatnagar S Chauhan R Chawla N Dhingra R Gupta A Kaur M Kaur S Kaur R Kumar P Kumari M Lohan A Mehta K Sandeep S Sharma J B Singh A K Virdi G Walia A Bhardwaj B C Choudhary R B Garg M Gola S Keshri Ashok Kumar S Malhotra M Naimuddin P Priyanka K Ranjan Aashaq Shah R Sharma R Bhardwaj M Bharti R Bhattacharya S Bhattacharya U Bhawandeep D Bhowmik S Dey S Dutt S Dutta S Ghosh K Mondal S Nandan A Purohit P K Rout A Roy S Roy Chowdhury G Saha S Sarkar M Sharan B Singh S Thakur P K Behera R Chudasama D Dutta V Jha V Kumar P K Netrakanti L M Pant P Shukla T Aziz M A Bhat S Dugad G B Mohanty N Sur B Sutar Ravindra Kumar Verma S Banerjee S Bhattacharya S Chatterjee P Das M Guchait Sa Jain S Karmakar S Kumar M Maity G Majumder K Mazumdar N Sahoo T Sarkar S Chauhan S Dube V Hegde A Kapoor K Kothekar S Pandey A Rane S Sharma S Chenarani E Eskandari Tadavani S M Etesami M Khakzad M Mohammadi Najafabadi M Naseri F Rezaei Hosseinabadi B Safarzadeh M Zeinali M Felcini M Grunewald M Abbrescia C Calabria A Colaleo D Creanza L Cristella N De Filippis M De Palma A Di Florio F Errico L Fiore A Gelmi G Iaselli M Ince S Lezki G Maggi M Maggi G Miniello S My S Nuzzo A Pompili G Pugliese R Radogna A Ranieri G Selvaggi A Sharma L Silvestris R Venditti P Verwilligen G Zito G Abbiendi C Battilana D Bonacorsi L Borgonovi S Braibant-Giacomelli R Campanini P Capiluppi A Castro F R Cavallo S S Chhibra C Ciocca G Codispoti M Cuffiani G M Dallavalle F Fabbri A Fanfani E Fontanesi P Giacomelli C Grandi L Guiducci F Iemmi S Lo Meo S Marcellini G Masetti A Montanari F L Navarria A Perrotta F Primavera T Rovelli G P Siroli N Tosi S Albergo A Di Mattia R Potenza A Tricomi C Tuve G Barbagli K Chatterjee V Ciulli C Civinini R D'Alessandro E Focardi G Latino P Lenzi M Meschini S Paoletti L Russo G Sguazzoni D Strom L Viliani L Benussi S Bianco F Fabbri D Piccolo F Ferro F Ravera E Robutti S Tosi A Benaglia A Beschi L Brianza F Brivio V Ciriolo S Di Guida M E Dinardo S Fiorendi S Gennai A Ghezzi P Govoni M Malberti S Malvezzi A Massironi D Menasce F Monti L Moroni M Paganoni D Pedrini S Ragazzi T Tabarelli de Fatis D Zuolo S Buontempo N Cavallo A Di Crescenzo F Fabozzi F Fienga G Galati A O M Iorio W A Khan L Lista S Meola P Paolucci C Sciacca E Voevodina P Azzi N Bacchetta D Bisello A Boletti A Bragagnolo R Carlin P Checchia M Dall'Osso P De Castro Manzano T Dorigo U Dosselli F Gasparini U Gasparini A Gozzelino S Y Hoh S Lacaprara P Lujan M Margoni A T Meneguzzo J Pazzini P Ronchese R Rossin F Simonetto A Tiko E Torassa M Zanetti P Zotto G Zumerle A Braghieri A Magnani P Montagna S P Ratti V Re M Ressegotti C Riccardi P Salvini I Vai P Vitulo M Biasini G M Bilei C Cecchi D Ciangottini L Fanò P Lariccia R Leonardi E Manoni G Mantovani V Mariani M Menichelli A Rossi A Santocchia D Spiga K Androsov P Azzurri G Bagliesi L Bianchini T Boccali L Borrello R Castaldi M A Ciocci R Dell'Orso G Fedi F Fiori L Giannini A Giassi M T Grippo F Ligabue E Manca G Mandorli A Messineo F Palla A Rizzi P Spagnolo R Tenchini G Tonelli A Venturi P G Verdini L Barone F Cavallari M Cipriani D Del Re E Di Marco M Diemoz S Gelli E Longo B Marzocchi P Meridiani G Organtini F Pandolfi R Paramatti F Preiato S Rahatlou C Rovelli F Santanastasio N Amapane R Arcidiacono S Argiro M Arneodo N Bartosik R Bellan C Biino N Cartiglia F Cenna S Cometti M Costa R Covarelli N Demaria B Kiani C Mariotti S Maselli E Migliore V Monaco E Monteil M Monteno M M Obertino L Pacher N Pastrone M Pelliccioni G L Pinna Angioni A Romero M Ruspa R Sacchi K Shchelina V Sola A Solano D Soldi A Staiano S Belforte V Candelise M Casarsa F Cossutti A Da Rold G Della Ricca F Vazzoler A Zanetti D H Kim G N Kim M S Kim J Lee S Lee S W Lee C S Moon Y D Oh S I Pak S Sekmen D C Son Y C Yang H Kim D H Moon G Oh J Goh T J Kim S Cho S Choi Y Go D Gyun S Ha B Hong Y Jo K Lee K S Lee S Lee J Lim S K Park Y Roh H S Kim J Almond J Kim J S Kim H Lee K Lee K Nam S B Oh B C Radburn-Smith S H Seo U K Yang H D Yoo G B Yu D Jeon H Kim J H Kim J S H Lee I C Park Y Choi C Hwang J Lee I Yu V Dudenas A Juodagalvis J Vaitkus I Ahmed Z A Ibrahim M A B Md Ali F Mohamad Idris W A T Wan Abdullah M N Yusli Z Zolkapli J F Benitez A Castaneda Hernandez J A Murillo Quijada H Castilla-Valdez E De La Cruz-Burelo M C Duran-Osuna I Heredia-De La Cruz R Lopez-Fernandez J Mejia Guisao R I Rabadan-Trejo M Ramirez-Garcia G Ramirez-Sanchez R Reyes-Almanza A Sanchez-Hernandez S Carrillo Moreno C Oropeza Barrera F Vazquez Valencia J Eysermans I Pedraza H A Salazar Ibarguen C Uribe Estrada A Morelos Pineda D Krofcheck S Bheesette P H Butler A Ahmad M Ahmad M I Asghar Q Hassan H R Hoorani A Saddique M A Shah M Shoaib M Waqas H Bialkowska M Bluj B Boimska T Frueboes M Górski M Kazana M Szleper P Traczyk P Zalewski K Bunkowski A Byszuk K Doroba A Kalinowski M Konecki J Krolikowski M Misiura M Olszewski A Pyskir M Walczak M Araujo P Bargassa C Beirão Da Cruz E Silva A Di Francesco P Faccioli B Galinhas M Gallinaro J Hollar N Leonardo M V Nemallapudi J Seixas G Strong O Toldaiev D Vadruccio J Varela S Afanasiev P Bunin M Gavrilenko I Golutvin I Gorbunov A Kamenev V Karjavine A Lanev A Malakhov V Matveev P Moisenz V Palichik V Perelygin S Shmatov S Shulha N Skatchkov V Smirnov N Voytishin A Zarubin V Golovtsov Y Ivanov V Kim E Kuznetsova P Levchenko V Murzin V Oreshkin I Smirnov D Sosnov V Sulimov L Uvarov S Vavilov A Vorobyev Yu Andreev A Dermenev S Gninenko N Golubev A Karneyeu M Kirsanov N Krasnikov A Pashenkov D Tlisov A Toropin V Epshteyn V Gavrilov N Lychkovskaya V Popov I Pozdnyakov G Safronov A Spiridonov A Stepennov V Stolin M Toms E Vlasov A Zhokin T Aushev R Chistov M Danilov P Parygin D Philippov S Polikarpov E Tarkovskii V Andreev M Azarkin I Dremin M Kirakosyan S V Rusakov A Terkulov A Baskakov A Belyaev E Boos V Bunichev M Dubinin L Dudko V Klyukhin O Kodolova N Korneeva I Lokhtin I Miagkov S Obraztsov M Perfilov V Savrin P Volkov A Barnyakov V Blinov T Dimova L Kardapoltsev Y Skovpen I Azhgirey I Bayshev S Bitioukov D Elumakhov A Godizov V Kachanov A Kalinin D Konstantinov P Mandrik V Petrov R Ryutin S Slabospitskii A Sobol S Troshin N Tyurin A Uzunian A Volkov A Babaev S Baidali V Okhotnikov P Adzic P Cirkovic D Devetak M Dordevic J Milosevic J Alcaraz Maestre A Álvarez Fernández I Bachiller M Barrio Luna J A Brochero Cifuentes M Cerrada N Colino B De La Cruz A Delgado Peris C Fernandez Bedoya J P 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F Fallavollita D Fasanella G Franzoni J Fulcher W Funk D Gigi A Gilbert K Gill F Glege M Guilbaud D Gulhan J Hegeman C Heidegger V Innocente A Jafari P Janot O Karacheban J Kieseler A Kornmayer M Krammer C Lange P Lecoq C Lourenço L Malgeri M Mannelli F Meijers J A Merlin S Mersi E Meschi P Milenovic F Moortgat M Mulders J Ngadiuba S Nourbakhsh S Orfanelli L Orsini F Pantaleo L Pape E Perez M Peruzzi A Petrilli G Petrucciani A Pfeiffer M Pierini F M Pitters D Rabady A Racz T Reis G Rolandi M Rovere H Sakulin C Schäfer C Schwick M Seidel M Selvaggi A Sharma P Silva P Sphicas A Stakia J Steggemann M Tosi D Treille A Tsirou V Veckalns M Verzetti W D Zeuner L Caminada K Deiters W Erdmann R Horisberger Q Ingram H C Kaestli D Kotlinski U Langenegger T Rohe S A Wiederkehr M Backhaus L Bäni P Berger N Chernyavskaya G Dissertori M Dittmar M Donegà C Dorfer T A Gómez Espinosa C Grab D Hits T Klijnsma W Lustermann R A Manzoni M Marionneau M T Meinhard F Micheli P Musella F Nessi-Tedaldi J Pata F 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Agaras A Cakir K Cankocak Y Komurcu S Sen B Grynyov L Levchuk F Ball L Beck J J Brooke D Burns E Clement D Cussans O Davignon H Flacher J Goldstein G P Heath H F Heath L Kreczko D M Newbold S Paramesvaran B Penning T Sakuma D Smith V J Smith J Taylor A Titterton K W Bell A Belyaev C Brew R M Brown D Cieri D J A Cockerill J A Coughlan K Harder S Harper J Linacre E Olaiya D Petyt C H Shepherd-Themistocleous A Thea I R Tomalin T Williams W J Womersley R Bainbridge P Bloch J Borg S Breeze O Buchmuller A Bundock D Colling P Dauncey G Davies M Della Negra R Di Maria Y Haddad G Hall G Iles T James M Komm C Laner L Lyons A-M Magnan S Malik A Martelli J Nash A Nikitenko V Palladino M Pesaresi D M Raymond A Richards A Rose E Scott C Seez A Shtipliyski G Singh M Stoye T Strebler S Summers A Tapper K Uchida T Virdee N Wardle D Winterbottom J Wright S C Zenz J E Cole P R Hobson A Khan P Kyberd C K Mackay A Morton I D Reid L Teodorescu S Zahid K Call J Dittmann K Hatakeyama H Liu C Madrid B Mcmaster N Pastika C Smith R Bartek A Dominguez A Buccilli S I Cooper C Henderson P Rumerio C West D Arcaro T Bose D Gastler D Rankin C Richardson J Rohlf L Sulak D Zou G Benelli X Coubez D Cutts M Hadley J Hakala U Heintz J M Hogan K H M Kwok E Laird G Landsberg J Lee Z Mao M Narain S Sagir R Syarif E Usai D Yu R Band C Brainerd R Breedon D Burns M Calderon De La Barca Sanchez M Chertok J Conway R Conway P T Cox R Erbacher C Flores G Funk W Ko O Kukral R Lander M Mulhearn D Pellett J Pilot S Shalhout M Shi D Stolp D Taylor K Tos M Tripathi Z Wang F Zhang M Bachtis C Bravo R Cousins A Dasgupta A Florent J Hauser M Ignatenko N Mccoll S Regnard D Saltzberg C Schnaible V Valuev E Bouvier K Burt R Clare J W Gary S M A Ghiasi Shirazi G Hanson G Karapostoli E Kennedy F Lacroix O R Long M Olmedo Negrete M I Paneva W Si L Wang H Wei S Wimpenny B R Yates J G Branson P Chang S Cittolin M Derdzinski R Gerosa D Gilbert B Hashemi A Holzner D Klein G Kole V Krutelyov J Letts M Masciovecchio D Olivito S Padhi M Pieri M Sani V Sharma S Simon M Tadel A Vartak S Wasserbaech J Wood F Würthwein A Yagil G Zevi Della Porta N Amin R Bhandari J Bradmiller-Feld C Campagnari M Citron A Dishaw V Dutta M Franco Sevilla L Gouskos R Heller J Incandela A Ovcharova H Qu J Richman D Stuart I Suarez S Wang J Yoo D Anderson A Bornheim J M Lawhorn H B Newman T Q Nguyen M Spiropulu J R Vlimant R Wilkinson S Xie Z Zhang R Y Zhu M B Andrews T Ferguson T Mudholkar M Paulini M Sun I Vorobiev M Weinberg J P Cumalat W T Ford F Jensen A Johnson M Krohn E MacDonald T Mulholland R Patel K Stenson K A Ulmer S R Wagner J Alexander J Chaves Y Cheng J Chu A Datta K Mcdermott N Mirman J R Patterson D Quach A Rinkevicius A Ryd L Skinnari L Soffi S M Tan Z Tao J Thom J Tucker P Wittich M Zientek S Abdullin M Albrow M Alyari G Apollinari A Apresyan A Apyan S Banerjee L A T Bauerdick A Beretvas J Berryhill P C Bhat G Bolla K Burkett J N Butler A Canepa G B Cerati H W K Cheung F Chlebana M Cremonesi J Duarte V D Elvira J Freeman Z Gecse E Gottschalk L Gray D Green S Grünendahl O Gutsche J Hanlon R M Harris S Hasegawa J Hirschauer Z Hu B Jayatilaka S Jindariani M Johnson U Joshi B Klima M J Kortelainen B Kreis S Lammel D Lincoln R Lipton M Liu T Liu J Lykken K Maeshima J M Marraffino D Mason P McBride P Merkel S Mrenna S Nahn V O'Dell K Pedro C Pena O Prokofyev G Rakness L Ristori A Savoy-Navarro B Schneider E Sexton-Kennedy A Soha W J Spalding L Spiegel S Stoynev J Strait N Strobbe L Taylor S Tkaczyk N V Tran L Uplegger E W Vaandering C Vernieri M Verzocchi R Vidal M Wang H A Weber A Whitbeck D Acosta P Avery P Bortignon D Bourilkov A Brinkerhoff L Cadamuro A Carnes M Carver D Curry R D Field S V Gleyzer B M Joshi J Konigsberg A Korytov K H Lo P Ma K Matchev H Mei G Mitselmakher D Rosenzweig K Shi D Sperka J Wang S Wang X Zuo Y R Joshi S Linn A Ackert T Adams A Askew S Hagopian V Hagopian K F Johnson T Kolberg G Martinez T Perry H Prosper A Saha C Schiber R Yohay M M Baarmand V Bhopatkar S Colafranceschi M Hohlmann D Noonan M Rahmani T Roy F Yumiceva M R Adams L Apanasevich D Berry R R Betts R Cavanaugh X Chen S Dittmer O Evdokimov C E Gerber D A Hangal D J Hofman K Jung J Kamin C Mills I D Sandoval Gonzalez M B Tonjes H Trauger N Varelas H Wang X Wang Z Wu J Zhang M Alhusseini B Bilki W Clarida K Dilsiz S Durgut R P Gandrajula M Haytmyradov V Khristenko J-P Merlo A Mestvirishvili A Moeller J Nachtman H Ogul Y Onel F Ozok A Penzo C Snyder E Tiras J Wetzel B Blumenfeld A Cocoros N Eminizer D Fehling L Feng A V Gritsan W T Hung P Maksimovic J Roskes U Sarica M Swartz M Xiao C You A Al-Bataineh P Baringer A Bean S Boren J Bowen A Bylinkin J Castle S Khalil A Kropivnitskaya D Majumder W Mcbrayer M Murray C Rogan S Sanders E Schmitz J D Tapia Takaki Q Wang S Duric A Ivanov K Kaadze D Kim Y Maravin D R Mendis T Mitchell A Modak A Mohammadi L K Saini N Skhirtladze F Rebassoo D Wright A Baden O Baron A Belloni S C Eno Y Feng C Ferraioli N J Hadley S Jabeen G Y Jeng R G Kellogg J Kunkle A C Mignerey S Nabili F Ricci-Tam Y H Shin A Skuja S C Tonwar K Wong D Abercrombie B Allen V Azzolini A Baty G Bauer R Bi S Brandt W Busza I A Cali M D'Alfonso Z Demiragli G Gomez Ceballos M Goncharov P Harris D Hsu M Hu Y Iiyama G M Innocenti M Klute D Kovalskyi Y-J Lee P D Luckey B Maier A C Marini C Mcginn C Mironov S Narayanan X Niu C Paus C Roland G Roland G S F Stephans K Sumorok K Tatar D Velicanu J Wang T W Wang B Wyslouch S Zhaozhong A C Benvenuti R M Chatterjee A Evans P Hansen Sh Jain S Kalafut Y Kubota Z Lesko J Mans N Ruckstuhl R Rusack J Turkewitz M A Wadud J G Acosta S Oliveros E Avdeeva K Bloom D R Claes C Fangmeier F Golf R Gonzalez Suarez R Kamalieddin I Kravchenko J Monroy J E Siado G R Snow B Stieger A Godshalk C Harrington I Iashvili A Kharchilava C Mclean D Nguyen A Parker S Rappoccio B Roozbahani G Alverson E Barberis C Freer A Hortiangtham D M Morse T Orimoto R Teixeira De Lima T Wamorkar B Wang A Wisecarver D Wood S Bhattacharya O Charaf K A Hahn N Mucia N Odell M H Schmitt K Sung M Trovato M Velasco R Bucci N Dev M Hildreth K Hurtado Anampa C Jessop D J Karmgard N Kellams K Lannon W Li N Loukas N Marinelli F Meng C Mueller Y Musienko M Planer A Reinsvold R Ruchti P Siddireddy G Smith S Taroni M Wayne A Wightman M Wolf A Woodard J Alimena L Antonelli B Bylsma L S Durkin S Flowers B Francis A Hart C Hill W Ji T Y Ling W Luo B L Winer S Cooperstein P Elmer J Hardenbrook S Higginbotham A Kalogeropoulos D Lange M T Lucchini J Luo D Marlow K Mei I Ojalvo J Olsen C Palmer P Piroué J Salfeld-Nebgen D Stickland C Tully S Malik S Norberg A Barker V E Barnes S Das L Gutay M Jones A W Jung A Khatiwada B Mahakud D H Miller N Neumeister C C Peng S Piperov H Qiu J F Schulte J Sun F Wang R Xiao W Xie T Cheng J Dolen N Parashar Z Chen K M Ecklund S Freed F J M Geurts M Kilpatrick W Li B P Padley R Redjimi J Roberts J Rorie W Shi Z Tu J Zabel A Zhang A Bodek P de Barbaro R Demina Y T Duh J L Dulemba C Fallon T Ferbel M Galanti A Garcia-Bellido J Han O Hindrichs A Khukhunaishvili P Tan R Taus A Agapitos J P Chou Y Gershtein E Halkiadakis M Heindl E Hughes S Kaplan R Kunnawalkam Elayavalli S Kyriacou A Lath R Montalvo K Nash M Osherson H Saka S Salur S Schnetzer D Sheffield S Somalwar R Stone S Thomas P Thomassen M Walker A G Delannoy J Heideman G Riley S Spanier O Bouhali A Celik M Dalchenko M De Mattia A Delgado S Dildick R Eusebi J Gilmore T Huang T Kamon S Luo R Mueller A Perloff L Perniè D Rathjens A Safonov N Akchurin J Damgov F De Guio P R Dudero S Kunori K Lamichhane S W Lee T Mengke S Muthumuni T Peltola S Undleeb I Volobouev Z Wang S Greene A Gurrola R Janjam W Johns C Maguire A Melo H Ni K Padeken J D Ruiz Alvarez P Sheldon S Tuo J Velkovska M Verweij Q Xu M W Arenton P Barria B Cox R Hirosky M Joyce A Ledovskoy H Li C Neu T Sinthuprasith Y Wang E Wolfe F Xia R Harr P E Karchin N Poudyal J Sturdy P Thapa S Zaleski M Brodski J Buchanan C Caillol D Carlsmith S Dasu L Dodd B Gomber M Grothe M Herndon A Hervé U Hussain P Klabbers A Lanaro K Long R Loveless T Ruggles A Savin V Sharma N Smith W H Smith N Woods

Phys Rev Lett 2018 Nov;121(22):221802

University of Wisconsin, Madison, Wisconsin, USA.

The first evidence of events consistent with the production of a single top quark in association with a photon is reported. The analysis is based on proton-proton collisions at sqrt[s]=13  TeV and recorded by the CMS experiment in 2016, corresponding to an integrated luminosity of 35.9  fb^{-1}. Read More

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November 2018

The Structural Effects of Modality on the Rise of Symbolic Language: A Rebuttal of Evolutionary Accounts and a Laboratory Demonstration.

Front Psychol 2018 28;9:2300. Epub 2018 Nov 28.

Laboratoire de Sciences Phonétiques, Département de Linguistique, Université de Montréal, Montreal, QC, Canada.

Why does symbolic communication in humans develop primarily in an oral medium, and how do theories of language origin explain this? Non-human primates, despite their ability to learn and use symbolic signs, do not develop symbols as in oral language. This partly owes to the lack of a direct cortico-motoneuron control of vocalizations in these species compared to humans. Yet such modality-related factors that can impinge on the rise of symbolic language are interpreted differently in two types of evolutionary storylines. Read More

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November 2018

Multiproxy evidence highlights a complex evolutionary legacy of maize in South America.

Science 2018 Dec;362(6420):1309-1313

Department of Life Science, University of Warwick, Coventry CV4 7AL, UK.

Domesticated maize evolved from wild teosinte under human influences in Mexico beginning around 9000 years before the present (yr B.P.), traversed Central America by ~7500 yr B. Read More

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December 2018

UGT1A1 genotypes and unconjugated hyperbilirubinemia phenotypes in post-neonatal Chinese children: A retrospective analysis and quantitative correlation.

Medicine (Baltimore) 2018 Dec;97(49):e13576

Department of Pediatrics, Jinshan Hospital of Fudan University, Shanghai, China.

To retrospectively analyze and quantitatively correlate UGT1A1 (bilirubin UDP- glucuronosyltransferase gene) genotypes and unconjugated hyperbilirubinemia (UCH) phenotypes among Chinese children.We retrospectively reviewed UCH patients, quantitatively analyzed genotype-phenotype correlation by comparing with healthy controls. Pfam database, SWISS-model, and Pymol were used for UGT1A1 protein domain analysis and protein modeling for assessing the effect of novel missense variants on protein structure. Read More

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December 2018

Red-flag sepsis and SOFA identifies different patient population at risk of sepsis-related deaths on the general ward.

Medicine (Baltimore) 2018 Dec;97(49):e13238

Department of Anaesthesia, Intensive Care and Pain Medicine, Division of Population Medicine, Cardiff University, Heath Park Campus, Cardiff.

Controversy exists regarding the best diagnostic and screening tool for sepsis outside the intensive care unit (ICU). Sequential organ failure assessment (SOFA) score has been shown to be superior to systemic inflammatory response syndrome (SIRS) criteria, however, the performance of "Red Flag sepsis criteria" has not been tested formally.The aim of the study was to investigate the ability of Red Flag sepsis criteria to identify the patients at high risk of sepsis-related death in comparison to SOFA based sepsis criteria. Read More

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December 2018

Periods of high dengue transmission defined by rainfall do not impact efficacy of dengue vaccine in regions of endemic disease.

PLoS One 2018 13;13(12):e0207878. Epub 2018 Dec 13.

Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America.

Objective: To evaluate the association of rainy season with overall dengue disease incidence and with the efficacy of the Sanofi Pasteur recombinant, live, attenuated, tetravalent vaccine (CYD-TDV) in two randomized, controlled multicenter phase III clinical trials in Asia and Latin America.

Methods: Rainy seasons were defined for each study site using climatological information from the World Meteorological Organization. The dengue attack rate in the placebo group for each study month was calculated as the number of symptomatic, virologically-confirmed dengue events in a given month divided by the number of participants at risk in the same month. Read More

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December 2018

Hydrogen finds a home in ionic devices.

Nat Mater 2019 Jan;18(1):7-8

NIST Center for Neutron Research, National Institute of Standards and Technology, Gaithersburg, MD, USA.

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January 2019

Dasatinib is preferentially active in the activated B-cell subtype of diffuse large B-cell lymphoma.

J Proteome Res 2018 Dec 12. Epub 2018 Dec 12.

Diffuse large B-cell lymphoma (DLBCL) is a heterogeneous disease, with at least one-third of its patients relapsing after treatment with the current chemotherapy regimen, R-CHOP. By gene expression profiling, patients with DLBCL can be categorized into two clinically relevant subtypes: activated B-cell (ABC) and germinal center B-cell (GCB) DLBCL. Patients with the ABC subtype have a poorer prognosis than those with GCB, and are defined by chronic, overactive signaling through the B-cell receptor and NF-κB pathways. Read More

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December 2018
2 Reads

Peptide receptor radionuclide therapy for patients with advanced pancreatic neuroendocrine tumors.

Semin Oncol 2018 Aug 24;45(4):236-248. Epub 2018 Oct 24.

Mayo Clinic Cancer Center, Rochester, MN, USA. Electronic address:

Lu-DOTATATE peptide receptor radionuclide therapy (PRRT) is now approved for patients with advanced gastroenteropancreatic neuroendocrine tumors (NET), and it is therefore important to understand the efficacy and safety of PRRT in this patient population. PRRT efficacy and safety outcomes have frequently been summarized for patient populations with gastroenteropancreatic NET, but not specifically in patients with pancreatic NET (panNET). The pivotal phase 3 trial of Lu-DOTATATE PRRT in NET was restricted to patients with a midgut primary site. Read More

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Engaging the African American Church to Improve Communication About Palliative Care and Hospice: Lessons From a Multilevel Approach.

J Palliat Care 2018 Dec 12:825859718810718. Epub 2018 Dec 12.

1 Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

Background:: As the spiritual family for many African Americans, the church presents an opportunity to improve communication about palliative care and hospice (PCH). However, sustainable change in church-based, practices related to PCH requires a compreshensive, multilevel approach.

Objectives:: Our primary goal was to encourage churches to embrace palliative care and hospice as acceptable alternatives for end-of-life care by creating venues to improve communications about PCH. Read More

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December 2018

Curators and sojourners in learning networks: Practices for transformation.

Authors:
Julie Risien

Eval Program Plann 2018 Dec 4;73:71-79. Epub 2018 Dec 4.

Center for Research on Lifelong STEM Learning, Oregon State University, 254 Gilbert Hall, Corvallis, OR, 97331, United States. Electronic address:

Networks are a promising mechanism for creating systemic change. Studies abound, but do not examine roles and practices to reveal the processes through which networks create transformative capacity. This participatory single case study provides a framework to examine structures, roles and practices. Read More

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December 2018

Updates on the use of intravesical therapies for non-muscle invasive bladder cancer: how, when and what.

World J Urol 2018 Dec 7. Epub 2018 Dec 7.

H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.

Introduction: Intravesical therapy has been an important aspect of the management of non-muscle invasive bladder cancer (NMIBC) for 40 years. Bacillus Calmette-Guerin (BCG) is considered standard of care for intermediate and high-grade non-invasive disease, yet understanding the nuances of subsequent intravesical therapy is important for any provider managing bladder cancer. Herein, we review the literature and describe optimal use of intravesical therapies for NMIBC. Read More

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December 2018

Influence of molecular weight on PNIPAM brush modified colloidal silica particles.

Soft Matter 2018 Dec 10. Epub 2018 Dec 10.

Priority Research Centre for Advanced Particle Processing and Transport, University of Newcastle, Callaghan, NSW 2308, Australia.

The effect of molecular weight and temperature on the phase transition and internal structure of poly(N-isopropylacrylamide) brush modified colloidal silica particles was investigated using dynamic light scattering (DLS) and small angle neutron scattering (SANS) between 15 and 45 °C. Dry particle analysis utilising transmission electron microscopy (TEM), Fourier-transform infrared spectroscopy (FTIR) and thermogravimetric analysis (TGA) all confirmed the thickness of the polymer brush shell increased as a function of polymerisation time. Hydrodynamic diameter and electrophoretic mobility results revealed that the brush modified particles transitioned from swollen shells to a collapsed conformation between 15 and 35 °C. Read More

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December 2018

Pre-mRNA modifications and their role in nuclear processing.

Quant Biol 2018 Sep 4;6(3):210-227. Epub 2018 Sep 4.

Department of Molecular Biophysics & Biochemistry, Yale University, New Haven, CT 06520, USA.

Background: Cellular non-coding RNAs are extensively modified post-transcriptionally, with more than 100 chemically distinct nucleotides identified to date. In the past five years, new sequencing based methods have revealed widespread decoration of eukaryotic messenger RNA with diverse RNA modifications whose functions in mRNA metabolism are only beginning to be known.

Results: Since most of the identified mRNA modifying enzymes are present in the nucleus, these modifications have the potential to function in nuclear pre-mRNA processing including alternative splicing. Read More

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September 2018

Factors associated with DAA virological treatment failure and resistance-associated substitutions description in HIV/HCV coinfected patients.

World J Hepatol 2018 Nov;10(11):856-866

Univ. Bordeaux, ISPED, Inserm, Bordeaux Population Health Research Center, team MORPH3EUS, UMR 1219, CIC-EC 1401, Bordeaux F-33000, France.

Aim: To describe factors associated with treatment failure and frequency of resistance-associated substitutions (RAS).

Methods: Human immunodeficiency virus (HIV)/hepatitis C virus (HCV) coinfected patients starting a first direct-acting antiviral (DAA) regimen before February 2016 and included in the French ANRS CO13 HEPAVIH cohort were eligible. Failure was defined as: (1) non-response [HCV-RNA remained detectable during treatment, at end of treatment (EOT)]; and (2) relapse (HCV-RNA suppressed at EOT but detectable thereafter). Read More

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November 2018

GABA-modulating bacteria of the human gut microbiota.

Nat Microbiol 2018 Dec 10. Epub 2018 Dec 10.

Antimicrobial Discovery Center, Department of Biology, Northeastern University, Boston, MA, USA.

The gut microbiota affects many important host functions, including the immune response and the nervous system. However, while substantial progress has been made in growing diverse microorganisms of the microbiota, 23-65% of species residing in the human gut remain uncultured, which is an obstacle for understanding their biological roles. A likely reason for this unculturability is the absence in artificial media of key growth factors that are provided by neighbouring bacteria in situ. Read More

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December 2018

PET neuroimaging reveals histone deacetylase dysregulation in schizophrenia.

J Clin Invest 2018 Dec 10. Epub 2018 Dec 10.

Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, USA.

Background: Patients with schizophrenia (SCZ) experience chronic cognitive deficits. Histone deacetylases (HDACs) are enzymes that regulate cognitive circuitry; however, the role of HDACs in cognitive disorders, including SCZ, remains unknown in humans. We previously determined that HDAC2 mRNA levels were lower in dorsolateral prefrontal cortex (DLPFC) tissue from donors with SCZ compared with controls. Read More

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December 2018

Intrinsic functional boundaries of lateral frontal cortex in the common marmoset monkey.

J Neurosci 2018 Dec 10. Epub 2018 Dec 10.

Centre for Functional and Metabolic Mapping, Robarts Research Institute, University of Western Ontario, London, Ontario, Canada, N6A 5B7

The common marmoset () is a small New World primate species that has been recently targeted as a potentially powerful preclinical model of human prefrontal cortex dysfunction. Although the structural boundaries of frontal cortex were described in marmosets at the start of the 20 century (Brodmann, 1909) and refined more recently (e.g. Read More

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December 2018

Development and Validation of a Diabetic Retinopathy Screening Modality Using a Hand-Held Nonmydriatic Digital Retinal Camera by Physician Graders at a Tertiary-Level Medical Clinic: Protocol for a Validation Study.

JMIR Res Protoc 2018 Dec 10;7(12):e10900. Epub 2018 Dec 10.

National Hospital of Sri Lanka, Colombo, Sri Lanka.

Background: Visual impairment and blindness from diabetic retinopathy (DR), which can be reduced by early screening and treatment, is an emerging public health concern in low-income and middle-income countries (LMICs) owing to the increasing prevalence of diabetes mellitus (DM). However, no systematic screening exists in most LMIC settings. The Western province of Sri Lanka has the highest prevalence of DM (18. Read More

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December 2018

Multi-omics and potential applications in wine production.

Curr Opin Biotechnol 2018 Dec 7;56:172-178. Epub 2018 Dec 7.

Section for Evolutionary Genomics, Natural History Museum of Denmark, University of Copenhagen, Copenhagen, Denmark; Norwegian University of Science and Technology, University Museum, Trondheim, Norway. Electronic address:

The wine microbiome - that is the microbial communities associated with the fermentation of must, is one of the most important factors in transforming grapes to wine, including flavour and aroma. Recent developments in high throughput sequencing and other 'omics methodologies are rapidly changing the level and complexity of information that we are able to extract from the wine microbiome. This will significantly enhance not only our understanding of which microbes are present at the various stages of the grapevine growth and winemaking process, but also improve our understanding of the complex interactions between microbes, the substrate and environment, ultimately shaping wine production. Read More

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December 2018
1 Read

Role of Post-Acute Care on Hospital Readmission After High-Risk Surgery.

J Surg Res 2019 Feb 6;234:116-122. Epub 2018 Oct 6.

Department of Urology, University of Pittsburgh, Pittsburgh, Pennsylvania.

Background: Payment models, including the Hospital Readmissions Reduction Program and bundled payments, place pressures on hospitals to limit readmissions. Against this backdrop, we sought to investigate the association of post-acute care after major surgery and readmission rates.

Methods: We identified patients undergoing high-risk surgery (abdominal aortic aneurysm repair, coronary bypass grafting, aortic valve replacement, carotid endarterectomy, esophagectomy, pancreatectomy, lung resection, and cystectomy) from 2005 to 2010 using the Healthcare Cost and Utilization Project's State Inpatient Database. Read More

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February 2019

Mental health first aid training among pharmacy and other university students and its impact on stigma toward mental illness.

Curr Pharm Teach Learn 2018 Oct 20;10(10):1342-1347. Epub 2018 Jul 20.

Purdue University College of Pharmacy, 575 West Stadium Avenue, West Lafayette, IN 47907, United States. Electronic address:

Background And Purpose: Information on effective and replicable methods employed in pharmacy and other college students to combat stigmatizing beliefs toward those with mental illness is limited. Mental Health First Aid (MHFA) is an international, standardized, eight-hour course focused on helping members of the general public triage a mental health crisis. The objective of this study was to determine the effect of MHFA training on stigmatizing attitudes toward those with mental illness among pharmacy and non-pharmacy students. Read More

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October 2018

Stereotactic body radiation therapy for stage I non-small cell lung carcinomas: Moderate hypofractionation optimizes outcome.

Lung Cancer 2018 Dec 16;126:201-207. Epub 2018 Nov 16.

Department of Radiotherapy, Centre Paul Strauss, 3, rue de la porte de l'hôpital, BP 42, 67065, Strasbourg cedex, France; Laboratory of Radiobiology, EA 3430, Fédération de Médecine Translationnelle de Strasbourg (FMTS), Strasbourg University, Strasbourg, France. Electronic address:

Objectives: In case of inoperability or refusal of surgery, stereotactic body radiation therapy (SBRT) is the most effective treatment for a stage I non-small cell lung carcinoma (NSCLC). The results obtained by this irradiation technique are considerably superior to those observed in the time of conventional 3D irradiation and its toxicities are much less important, which makes it possible in elderly patients, or those presenting cardio-pulmonary comorbidities and a poor perfomance status.

Materials And Methods: This study is a retrospective analysis of 90 patients who underwent SBRT for a stage I NSCLC between 2010 and 2015. Read More

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December 2018

Evaluation of magnesium alloys for use as an intraluminal tracheal for pediatric applications in a rat tracheal bypass model.

J Biomed Mater Res B Appl Biomater 2018 Dec 6. Epub 2018 Dec 6.

Department of Bioengineering, University of Pittsburgh, Pittsburgh, Pennsylvania, 15261.

Tracheal stenting currently using non-degradable stents is commonplace for treatment of trauma, prolonged intubation related adult airway obstructions, and pediatric patients-associated tracheal stenosis conditions. Degradable tracheal stent placement will avoid complications of stent removal and restenosis. Widespread reports exist on degradable magnesium alloys success for orthopedic and cardiovascular applications but none to date for intra tracheal use. Read More

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December 2018
4 Reads

Benzene Exposure Response and Risk of Myeloid Neoplasms in Chinese Workers: A Multicenter Case-Cohort Study.

J Natl Cancer Inst 2018 Dec 6. Epub 2018 Dec 6.

Nanchang Center for Disease Control and Prevention, Nanchang, China.

Background: There is international consensus that benzene exposure is causally related to acute myeloid leukemia (AML), and more recent evidence of association with myelodysplastic syndromes (MDS). However, there are uncertainties about the exposure response, particularly risks by time since exposure and age at exposure.

Methods: In a case-cohort study in 110 631 Chinese workers followed up during 1972-1999 we evaluated combined MDS/AML (n = 44) and chronic myeloid leukemia (n = 18). Read More

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December 2018
4 Reads

Long-term safety and activity of axicabtagene ciloleucel in refractory large B-cell lymphoma (ZUMA-1): a single-arm, multicentre, phase 1-2 trial.

Lancet Oncol 2018 Nov 30. Epub 2018 Nov 30.

University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Background: Axicabtagene ciloleucel is an autologous anti-CD19 chimeric antigen receptor (CAR) T-cell therapy. In the previous analysis of the ZUMA-1 registrational study, with a median follow-up of 15·4 months (IQR 13·7-17·3), 89 (82%) of 108 assessable patients with refractory large B-cell lymphoma treated with axicabtagene ciloleucel achieved an objective response, and complete responses were noted in 63 (58%) patients. Here we report long-term activity and safety outcomes of the ZUMA-1 study. Read More

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November 2018
1 Read
24.690 Impact Factor

Optimization of production of vesicular stomatitis virus (VSV) in suspension serum-free culture medium at high cell density.

J Biotechnol 2018 Nov 30;289:144-149. Epub 2018 Nov 30.

Department of Bioprocess Engineering, National Research Council Canada, Building Montreal, Montréal, Canada; Department of Bioengineering McGill University, Montréal, Canada.

During the last decade, oncolytic viruses such as vesicular stomatitis virus (VSV) have gained tremendous popularity as efficient vaccines for infectious diseases as well as for the treatment of cancer. Our laboratory has developed two stable cell lines, 293SF-3F6 (derived from HEK293A cells) and SF-BMAdR cells (a variant of A549 that expresses the E1 region of human adenovirus). These two cell lines were adapted to grow efficiently in suspension culture and in serum-free medium. Read More

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November 2018

Caspase- (8/3) Activation and Organ Inflammation in a Rat Model of Resuscitated Hemorrhagic Shock: A Role for Uric Acid.

J Trauma Acute Care Surg 2018 Nov 30. Epub 2018 Nov 30.

Centre de Recherche de l'Hôpital du Sacré-Cœur de Montréal (HSCM), 5400 boul. Gouin Ouest, Montréal, Québec, H4J 1C5, Canada.

Background: Multiple organ failure can develop after hemorrhagic shock (HS). Uric acid (UA) is released from dying cells and can be pro-inflammatory. We hypothesized that UA could be an alternative mediator of organ apoptosis and inflammation after HS. Read More

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November 2018
1 Read

EFFECT OF HIGH-DENSITY ORAL RABIES VACCINE BAITING ON RABIES VIRUS NEUTRALIZING ANTIBODY RESPONSE IN RACCOONS ( PROCYON LOTOR).

J Wildl Dis 2018 Dec 3. Epub 2018 Dec 3.

3   US Department of Agriculture, Animal and Plant Health Inspection Service, Wildlife Services, National Rabies Management Program, 59 Chenell Drive, Concord, New Hampshire 03301, USA.

From 2014 to 2016, we examined the effect of distributing oral rabies vaccine baits at high density (150 baits/km) in an area of Virginia that was naïve to oral rabies vaccination prior to the study. We also compared the effect of baiting at high density in a naïve area to baiting at standard density (75 baits/km) in an area that had been baited annually for 12 yr. Our results suggested that rabies virus seroconversion in raccoons ( Procyon lotor) gradually increased each year under the high-density bait treatment. Read More

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December 2018

Electrochemical potential zone of viability on CoCrMo surfaces is affected by cell type: Macrophages under cathodic bias are more resistant to killing.

J Biomed Mater Res A 2018 Dec 3. Epub 2018 Dec 3.

Department of Biomedical and Chemical Engineering, Syracuse University, Syracuse, New York.

Electrochemical interactions at the cell-metal interface determine cell viability and influence behavior in response to different electrode potential conditions, specifically cathodic biases. Mechanically assisted crevice corrosion, for example, induces cathodic potentials and the associated electrochemical consequences of increased reduction reactions at the implant surface may affect cell viability in a manner that is different for various cell phenotypes. Monocyte macrophage-like U937 cells were cultured on cobalt-chromium-molybdenum (CoCrMo) metal surfaces in vitro for 24 h to assess cell behavior in response to sustained applied voltages. Read More

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December 2018
1 Read

Immunological modulation following bone marrow-derived mesenchymal stromal cells and Th17 lymphocyte co-cultures.

Inflamm Res 2018 Nov 30. Epub 2018 Nov 30.

Osteoarthritis Research Unit, Department of Medicine, University of Montreal Hospital Research Center (CRCHUM), 900 rue Saint-Denis, R11.424, Montreal, QC, H2X 0A9, Canada.

Objective And Design: The objective of the study is to uncover the influence of human bone marrow-derived mesenchymal stem cells (BM-MSCs) on the generation of Th17 lymphocytes in co-cultures of both BM-MSCs and T cells.

Materials And Methods: BM-MSCs, characterized according to the international society for cellular therapy (ISCT) criteria, were co-cultured with T cells isolated from peripheral blood. The expression levels of IL-17 receptor, RORγt and IL-23 receptor were evaluated using flow cytometry. Read More

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November 2018
1 Read

A review and analysis of strategies for prediction, prevention and management of post-operative atrial fibrillation after non-cardiac thoracic surgery.

J Thorac Dis 2018 Nov;10(Suppl 32):S3799-S3808

Division of Thoracic Surgery, The Ottawa Hospital, University of Ottawa, Ottawa, ON, Canada.

Atrial fibrillation (AF) is the most common sustained arrhythmia after non-cardiac thoracic surgery and is associated with a significant increase in perioperative morbidity, intensive care unit (ICU) admission, and mortality. Practical guidance is needed to assist clinicians in managing this critical issue and direct further research. Here we aim to provide a synoptic review and analysis of the literature to distil practical recommendations for prediction, prevention and management of post-operative atrial fibrillation (POAF) suitable for clinical application and further evaluation. Read More

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November 2018
1 Read

Forecasting pulmonary air leak duration following lung surgery using transpleural airflow data from a digital pleural drainage device.

J Thorac Dis 2018 Nov;10(Suppl 32):S3747-S3754

Division of Thoracic Surgery, University of Ottawa, Ottawa, Ontario, Canada.

Background: Prolonged air leak (PAL) is often the limiting factor for hospital discharge after lung surgery. Our goal was to develop a statistical model that reliably predicts pulmonary air leak resolution by applying statistical time series modeling and forecasting techniques to digital drainage data.

Methods: Autoregressive Integrated Moving Average (ARIMA) modeling was used to forecast air leak flow from transplural air flow data. Read More

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November 2018
2 Reads

Aiming for evidence-based best practices in thoracic surgery-leadership in surgery.

J Thorac Dis 2018 Nov;10(Suppl 32):S3726-S3727

Division of Thoracic Surgery, Department of Surgery, University of Ottawa, Ottawa, Ontario, Canada.

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November 2018
2 Reads

Effects of seating load magnitude and load orientation on seating mechanics in 5°40' mixed-alloy modular taper junctions.

J Biomech 2018 Nov 4. Epub 2018 Nov 4.

Syracuse University, Syracuse Biomaterials Institute, Syracuse, NY, United States; Department of Bioengineering, Clemson University, Charleston, SC, United States. Electronic address:

Background: Mechanically-assisted crevice corrosion of modular tapers continues to be a concern in total joint replacements. Surgical factors that may affect taper seating mechanics include seating load magnitude and load orientation. Seating mechanics is defined as the seating load versus displacement behavior. Read More

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November 2018

Biomaterial Approaches to Modulate Reactive Astroglial Response.

Cells Tissues Organs 2018 Dec 5:1-24. Epub 2018 Dec 5.

Department of Biomedical Engineering, Rensselaer Polytechnic Institute, Troy, New York,

Over several decades, biomaterial scientists have developed materials to spur axonal regeneration and limit secondary injury and tested these materials within preclinical animal models. Rarely, though, are astrocytes examined comprehensively when biomaterials are placed into the injury site. Astrocytes support neuronal function in the central nervous system. Read More

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December 2018
3 Reads

Medication Management Capacity and Its Neurocognitive Correlates in Huntington's Disease.

Arch Clin Neuropsychol 2018 Dec 5. Epub 2018 Dec 5.

Department of Psychology, Washington State University, Pullman, WA, USA.

Objective: Although medication management is a necessary daily activity for individuals with Huntington's disease (HD), medication management abilities and their relation to cognitive functioning have not been evaluated.

Method: Twenty individuals with HD and 20 healthy adults (HA) completed the Medication Management Abilities Assessment (MMAA). Individuals with HD also completed a self-report medication management measure and neuropsychological tests assessing executive function, retrospective memory, and prospective memory. Read More

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December 2018
3 Reads

The diagnostic performance of a simplified blood test (SteatoTest-2) for the prediction of liver steatosis.

Eur J Gastroenterol Hepatol 2018 Dec 3. Epub 2018 Dec 3.

Department of Hepatology, Assistance Publique-Hôpitaux de Paris, Pitié-Salpêtrière Hospital.

Background: Serum biomarkers of steatosis such as the SteatoTest are recommended for large-scale screening studies, because imaging is less accessible and more expensive.

Aims: The primary aim of this retrospective analysis of prospective studies was to construct a new SteatoTest-2 that was not inferior to the reference first-generation SteatoTest, but that did not include BMI or bilirubin, as these two components can increase test variability because of the assessment of weight and height and in case of Gilbert syndrome or hemolysis, respectively.

Patients And Methods: Five different subsets of 2997 patients with biopsies were evaluated for test construction and validation, and four to assess the prevalence of steatosis in target populations with increasing risks of steatosis. Read More

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December 2018

Injectable, magnetically-orienting electrospun fiber conduits for neuron guidance.

ACS Appl Mater Interfaces 2018 Dec 5. Epub 2018 Dec 5.

Magnetic electrospun fibers are of interest to biomaterial applications that strive to provide cell guidance that can be delivered using minimally invasive techniques. Magnetic electrospun fibers can be injected then magnetically positioned in situ, and the aligned fiber scaffolds provide consistent topographical guidance to cells. We developed and tested magnetically-responsive aligned poly-L-lactic acid (PLLA) electrospun fiber scaffolds for neural applications. Read More

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December 2018
3 Reads

Gut microbial features can predict host phenotype response to protein deficiency.

Physiol Rep 2018 Dec;6(23):e13932

Department of Medicine, Division of Endocrinology, Diabetes, and Metabolism, University of Illinois at Chicago, Chicago, IL.

Malnutrition remains a major health problem in low- and middle-income countries. During low protein intake, <0.67 g/kg/day, there is a loss of nitrogen (N ) balance, due to the unavailability of amino acid for metabolism and unbalanced protein catabolism results. Read More

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December 2018

Proliferation characteristics of cells cultured under periodic versus static conditions.

Cytotechnology 2018 Dec 4. Epub 2018 Dec 4.

Cellasys GmbH, Kronburg, Germany.

In vitro culture models have become an indispensable tool for assessing a vast variety of biological questions in many scientific fields. However, common in vitro cultures are maintained under static conditions, which do not reflect the in vivo situation and create a non-physiological environment. To assess whether the growth characteristics of cells cultured at pulsed-perfused versus static conditions differ, we observed the growth of differentially cultured cells in vitro by life-cell time-lapse imaging of recombinant HEK293 cells, stably expressing yellow fluorescent protein. Read More

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December 2018
5 Reads

Adaptation, Implementation, and Evaluation of a Public Health Research Methods Training for Youth.

Health Equity 2018 30;2(1):349-355. Epub 2018 Nov 30.

Brown School of Social Work, Washington University in St. Louis, St. Louis, Missouri.

To adapt, implement, and evaluate a public health research methods training program for youth. The Community Research Fellows Training Program is an evidence-based public health research methods training program for adults (18 years and older). The Youth Research Fellows Training (YRFT) is an adaptation of this program for youth. Read More

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November 2018

MGMT Promoter Methylation Cutoff with Safety Margin for Selecting Glioblastoma Patients into Trials Omitting Temozolomide. A Pooled Analysis of Four Clinical Trials.

Clin Cancer Res 2018 Dec 4. Epub 2018 Dec 4.

Laboratory of Molecular Neuro-Oncology, Department of Neurology, University Hospital and University of Zurich.

Purpose: The methylation status of the O6-methylguanine DNA methyltransferase (MGMT) gene promoter is predictive for benefit from temozolomide in glioblastoma. A clinically optimized cutoff was sought allowing patient selection for therapy without temozolomide, while avoiding to withhold it from patients who may potentially benefit.

Experimental Design: Quantitative MGMT methylation-specific PCR data were obtained for newly diagnosed glioblastoma patients screened or treated with standard radiotherapy and temozolomide in four randomized trials. Read More

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December 2018

Landscape structure affects the prevalence and distribution of a tick-borne zoonotic pathogen.

Parasit Vectors 2018 Dec 4;11(1):621. Epub 2018 Dec 4.

Institute of Biodiversity, Animal Health and Comparative Medicine, University of Glasgow, Glasgow, Scotland, UK.

Background: Landscape structure can affect pathogen prevalence and persistence with consequences for human and animal health. Few studies have examined how reservoir host species traits may interact with landscape structure to alter pathogen communities and dynamics. Using a landscape of islands and mainland sites we investigated how natural landscape fragmentation affects the prevalence and persistence of the zoonotic tick-borne pathogen complex Borrelia burgdorferi (sensu lato), which causes Lyme borreliosis. Read More

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December 2018
1 Read

Systemic Dissemination of Injected Foreign Material.

J Forensic Sci 2018 Dec 4. Epub 2018 Dec 4.

Forensic Science SA, GPO Box 2790, Adelaide, 5001.

A 32-year-old woman collapsed following an intravenous injection of material that included crushed pharmaceutical tablets. Resuscitation was attempted but was unsuccessful. She had an extensive past medical history of complications resulting from intravenous drug use. Read More

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December 2018
3 Reads

Prognostic model to predict postoperative acute kidney injury in patients undergoing major gastrointestinal surgery based on a national prospective observational cohort study.

Authors:

BJS Open 2018 Dec 27;2(6):400-410. Epub 2018 Jul 27.

Background: Acute illness, existing co-morbidities and surgical stress response can all contribute to postoperative acute kidney injury (AKI) in patients undergoing major gastrointestinal surgery. The aim of this study was prospectively to develop a pragmatic prognostic model to stratify patients according to risk of developing AKI after major gastrointestinal surgery.

Methods: This prospective multicentre cohort study included consecutive adults undergoing elective or emergency gastrointestinal resection, liver resection or stoma reversal in 2-week blocks over a continuous 3-month period. Read More

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December 2018
7 Reads