5,968 results match your criteria Giardiasis


Efficacy of 5-nitroimidazole compounds for giardiasis in Cuban children: systematic review and meta-analysis.

Infez Med 2019 Mar;27(1):58-67

University of the Basque Country UPV/EHU and CIBERSAM. Medical School, Department of Neuroscience, Leioa, Spain.

Five-nitroimidazole (5-NI) compounds are among the most commonly used medications in the treatment of giardiasis. However, after more than five decades of their initial indication for such treatment, there are some concerns about the efficacy of 5-NIs in giardiasis. This study sought to compare the efficacy of any 5-NI with any other antigiardial drug for the treatment of Cuban children with giardiasis. Read More

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Giardia lamblia subtypes and their relationship with clinical symptoms in patients with giardiasis.

Infect Disord Drug Targets 2019 Mar 13. Epub 2019 Mar 13.

Department of Psychiatry, Faculty of medicine, Ilam University of Medical Sciences, Ilam. Iran.

Giardia lamblia has proved to be the most common intestinal protozoan parasite in humans that causes giardiasis. Given the high mutations in the genome of this parasite, the present study was conducted to determine the prevalence of Giardia lamblia subtypes and their relationship with clinical symptoms in patients who appear to have giardiasis. In 69 stool specimens with an appropriate number of giardia cysts, the DNA was first purified, and the genotype was then determined based on the glutamate dehydrogenase (gdh) gene sequence using PCR-RFLP. Read More

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http://dx.doi.org/10.2174/1871526519666190314094437DOI Listing
March 2019
1 Read

Identification of a novel potassium channel (GiK) as a potential drug target in : Computational descriptions of binding sites.

PeerJ 2019 27;7:e6430. Epub 2019 Feb 27.

Departamento de Microbiología y Patología, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico.

Background: The protozoan is the causal agent of giardiasis, one of the main diarrheal infections worldwide. Drug resistance to common antigiardial agents and incidence of treatment failures have increased in recent years. Therefore, the search for new molecular targets for drugs against infection is essential. Read More

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http://dx.doi.org/10.7717/peerj.6430DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6397635PMC
February 2019
3 Reads

Cytopreparation of duodenal biopsy fixative improves detection rate of Giardia in clinically suspected cases.

Cytopathology 2019 Feb 28. Epub 2019 Feb 28.

Department of Pathology, GB Pant Institute of Postgraduate Medical Education and Research, New Delhi, 110002.

Background: Giardia intestinalis is a flagellated protozoan, frequently documented as an agent for enteric illness worldwide. Laboratory procedures for diagnosis include stool examination, antigenic detection assays and at times mucosal biopsy. We hypothesized that the formalin fixative used as a preservative for mucosal biopsy can be a good diagnostic sample for detecting surface mucosal and luminal infective agents like Giardia. Read More

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http://dx.doi.org/10.1111/cyt.12684DOI Listing
February 2019
1 Read

Frequencies of Common Infectious Organisms Causing Chronic Diarrhea in Renal Transplant Patients.

Exp Clin Transplant 2019 01;17(Suppl 1):212-215

From the Department of Hepatogastroenterology, Sindh Institute of Urology and Transplantation, Karachi, Pakistan.

Objectives: Gastrointestinal complications are common in kidney transplant patients, with the most frequent being diarrhea (60%). Chronic diarrhea affects the patient's quality of life, causes fatigue and weight loss and malabsorption, increases the number of hospitalizations, increases serum creatinine levels, and causes alterations in immunosuppressive drug levels. Diarrhea is also associated with an increased risk of graft failure and death. Read More

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http://dx.doi.org/10.6002/ect.MESOT2018.P69DOI Listing
January 2019
2 Reads
0.798 Impact Factor

Detection and molecular characterization of Giardia spp. in captive Psittaciformes in Brazil.

Prev Vet Med 2019 Mar 15;164:10-12. Epub 2019 Jan 15.

Universidade Estadual Paulista (Unesp), Faculdade de Medicina Veterinária, Araçatuba. Rua Clóvis Pestana, 793, CEP 16050-680, Bairro Dona Amélia, Araçatuba, SP, Brazil. Electronic address:

This study aimed to perform the detection and molecular characterization of Giardia spp. in Psittaciformes from the Southern and Southeastern regions of Brazil. Fecal samples were obtained from 359 adult exotic captive Psittaciformes belonging to 13 genera, randomly selected from 33 aviaries located in the Southern and Southeastern regions of Brazil during a bird exhibition at the 2015 Ornithological Championship of the Ornithological Federation of Brazil (FOB). Read More

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http://dx.doi.org/10.1016/j.prevetmed.2019.01.006DOI Listing
March 2019
1 Read

Quality of life and its association with irritable bowel syndrome and fatigue ten years after giardiasis.

Neurogastroenterol Motil 2019 Feb 14:e13559. Epub 2019 Feb 14.

Research Unit for General Practice, NORCE Norwegian Research Centre, Bergen, Norway.

Background: Gastroenteritis has been associated with complications such as irritable bowel syndrome (IBS) and chronic fatigue (CF). Little is known about the implications for quality of life (QoL) in this setting. The aims of this study were to evaluate the association between exposure to Giardia infection and QoL ten years after the infection, and how this related to IBS and CF. Read More

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http://dx.doi.org/10.1111/nmo.13559DOI Listing
February 2019
1 Read

Comparison of multiplexed-tandem real-time PCR panel with reference real-time PCR molecular diagnostic assays for detection of Giardia intestinalis and Tritrichomonas foetus in cats.

Vet Parasitol 2019 Feb 6;266:12-17. Epub 2019 Jan 6.

Veterinary Pathology Diagnostic Services, Sydney School of Veterinary Science, University of Sydney, NSW 2006, Australia. Electronic address:

Giardia intestinalis and Tritrichomonas foetus are frequent enteric protozoan parasites of the gastrointestinal track of domestic cats. Because of different treatment options for the parasites, confirmation of presence of one or both pathogens is necessary. The PCR based assays are suitable for differential diagnosis. Read More

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http://dx.doi.org/10.1016/j.vetpar.2018.12.009DOI Listing
February 2019
3 Reads

Etiology and severity of diarrheal diseases in infants at the semiarid region of Brazil: A case-control study.

PLoS Negl Trop Dis 2019 02 8;13(2):e0007154. Epub 2019 Feb 8.

INCT-Biomedicine and Department of Physiology and Pharmacology, Faculty of Medicine, Federal University of Ceará, Fortaleza, CE, Brazil.

Background: Diarrheal diseases are an important cause of morbidity and mortality among children in developing countries. We aimed to study the etiology and severity of diarrhea in children living in the low-income semiarid region of Brazil.

Methodology: This is a cross-sectional, age-matched case-control study of diarrhea in children aged 2-36 months from six cities in Brazil's semiarid region. Read More

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http://dx.plos.org/10.1371/journal.pntd.0007154
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http://dx.doi.org/10.1371/journal.pntd.0007154DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6383952PMC
February 2019
5 Reads

A Novel Nano Magnetic Beads Dot ELISA Immunoassay and Its Application on the Detection of Coproantigen.

Iran J Parasitol 2018 Oct-Dec;13(4):532-540

Dept. of Parasitology, Faculty of Medicine, Benha University, Benha, Egypt.

Background: The traditional basis of diagnosis is identification of trophozoites or cysts in the stool of infected patients. Recently the advent of more objective techniques like antigen detection methods has led to an increase in their use versus those that rely on subjective microscopic examination of fecal specimens for cysts may facilitate diagnosis of in stool specimens.

Methods: This cross-sectional study was carried out from Oct 2015 to Feb 2016 on patients admitted to Benha University Hospitals (Benha, Egypt) and outpatients of Theodor Bilharz Research Institute (TBRI) (Giza, Egypt). Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348222PMC
January 2019

The International Collaborative on Fatigue Following Infection (COFFI).

Fatigue 2018 19;6(2):106-121. Epub 2018 Jan 19.

Kirby Institute, University of New South Wales, Sydney, New South Wales, Australia.

Background: The purpose of the Collaborative on Fatigue Following Infection (COFFI) is for investigators of post-infection fatigue (PIF) and other syndromes to collaborate on these enigmatic and poorly understood conditions by studying relatively homogeneous populations with known infectious triggers. Utilizing COFFI, pooled data and stored biosamples will support both epidemiological and laboratory research to better understand the etiology and risk factors for development and progression of PIF.

Methods: COFFI consists of prospective cohorts from the UK, Netherlands, Norway, USA, New Zealand and Australia, with some cohorts closed and some open to recruitment. Read More

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https://www.tandfonline.com/doi/full/10.1080/21641846.2018.1
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http://dx.doi.org/10.1080/21641846.2018.1426086DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333416PMC
January 2018
7 Reads

Molecular characterisation and taxon assemblage typing of giardiasis in primary school children living close to the shoreline of Lake Albert, Uganda.

Parasite Epidemiol Control 2019 Feb 23;4:e00074. Epub 2018 Nov 23.

Department of Parasitology, Liverpool School of Tropical Medicine, Liverpool L3 5QA, UK.

As part of an epidemiological survey for gastrointestinal parasites in school children across five primary schools on the shoreline of Lake Albert, the prevalence of giardiasis was 87.0% (n = 254) as determined by real-time PCR analysis of faecal samples with a genus-specific 18S rDNA probe. Faecal samples were further characterised with taxon assemblage-specific triose phosphate isomerase (TPI) Taqman® probes and by sequence characterisation of the -giardin gene. Read More

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http://dx.doi.org/10.1016/j.parepi.2018.e00074DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6324016PMC
February 2019
1 Read

Characterization of proteolytic activities of Giardia lamblia with the ability to cleave His-tagged N-terminal sequences.

Mol Biochem Parasitol 2019 Mar 15;228:16-26. Epub 2019 Jan 15.

Grupo de Investigación en Biomoléculas y Salud Infantil, Laboratorio de EIMyT, Instituto Nacional de Pediatría, S.S., Mexico City, 04530, Mexico. Electronic address:

Giardia lamblia is one of the most common protozoan infectious agents in the world and is responsible for diarrheal disease and chronic postinfectious illness. During the host-parasite interaction, proteases are important molecules related to virulence, invasion, and colonization, not only for Giardia but also for other parasites. We aimed to characterize the cysteine protease activity detected in trophozoite lysates. Read More

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http://dx.doi.org/10.1016/j.molbiopara.2019.01.001DOI Listing
March 2019
3 Reads

Therapeutic uses of metronidazole and its side effects: an update.

Eur Rev Med Pharmacol Sci 2019 Jan;23(1):397-401

Área Académica de Medicina, Instituto de Ciencias de la Salud, Universidad Autónoma del Estado de Hidalgo, Circuito Ex Hacienda, Pachuca de Soto Hidalgo, México.

Objective: Metronidazole is an antibiotic widely used in different medical conditions such as trichomoniasis, amoebiasis, and giardiasis among others. Its use has been associated with toxicity; however, it is not well characterized. In this review, we discuss the different therapeutic uses of metronidazole and its side effects in order to aid future investigation in this field. Read More

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http://dx.doi.org/10.26355/eurrev_201901_16788DOI Listing
January 2019
3 Reads

Prevalence and genotypic identification of Cryptosporidium spp., Giardia duodenalis and Enterocytozoon bieneusi in pre-weaned dairy calves in Guangdong, China.

Parasit Vectors 2019 Jan 17;12(1):41. Epub 2019 Jan 17.

Key Laboratory of Zoonosis of Ministry of Agriculture, College of Veterinary Medicine, South China Agricultural University, Guangzhou, 510642, China.

Background: Cryptosporidium spp., Giardia duodenalis and Enterocytozoon bieneusi are common enteric pathogens in humans and animals. Data on the transmission of these pathogens are scarce from Guangdong, China, which has a subtropical monsoon climate and is the epicenter for many emerging infectious diseases. Read More

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http://dx.doi.org/10.1186/s13071-019-3310-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337774PMC
January 2019
4 Reads

[THE ITERATIVE APPROACH TO PRICING LABORATORY SERVICES FOR THE PROVISION OF MEDICAL AID (COPROPROCYCOSOPHICAL EXAMINATION ON LYAMBLIOSIS)].

Georgian Med News 2018 Nov(284):136-140

Kharkiv Medical Academy of Postgraduate Education of the Ministry of Health of Ukraine; Yaroslav Mudriy National Law University, Kharkiv, Ukraine.

The purpose of the study was to substantiate the theoretical and methodical principles of pricing for laboratory services in the diagnosis of giardiasis, taking into account their iterability and peculiarities of parasitic research methods. The methods of laboratory study of gum disease of native smear, treated with Lyulol solution, and ether-formalin enrichment on the criteria of their quality and effectiveness are analyzed. On the basis of the study of the effectiveness of the first and repeated analyzes, the conclusion on the iterative nature of laboratory studies of giardiasis and the effectiveness of the use of an iterative approach to the determination of prices for laboratory services is substantiated. Read More

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November 2018
7 Reads

Comparative Analysis of Antigiardial Potential of Heat Inactivated and Probiotic Protein of Probiotic Lactobacillus rhamnosus GG in Murine Giardiasis.

Probiotics Antimicrob Proteins 2019 Jan 4. Epub 2019 Jan 4.

Department of Microbiology, Basic Medical Sciences, Panjab University, (Block-1), South Campus, Chandigarh, 160014, India.

The present study was designed to envisage the antigiardial efficacy of killed probiotic and probiotic protein (PP) of Lactobacillus rhamnosus GG in murine giardiasis. Experimentally, it was observed that animal administered either with probiotic protein emulsified with adjuvant (PP + Giardia) or killed probiotic (killed probiotic (i/p) + Giardia) had significantly reduced Giardia cycle with respect to observed severity and duration of giardiasis compared with Giardia-infected mice. Further, it was found that animals belonging to PP + Giardia and killed probiotic (i/p) + Giardia had significantly high levels of antigiardial IgA antibody and nitric oxide both in serum and in intestinal fluid compared with Giardia-infected and counter control mice. Read More

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http://link.springer.com/10.1007/s12602-018-9506-8
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http://dx.doi.org/10.1007/s12602-018-9506-8DOI Listing
January 2019
7 Reads

Study on Giardia duodenalis and Cryptosporidium spp. infection in veterinarians in Poland.

Ann Agric Environ Med 2018 Dec 18;25(4):732-733. Epub 2018 Dec 18.

Institute of Rural Health, Lublin, Poland.

The risk of exposure to zoonotic factors among veterinarians comprises still underestimated problem. Many etiological factors of infectious diseases are so far poorly known, including the way of their transmission from environment to humans and their impact for health. The main aim of the study was to determine the risk of two selected zoonosis infections caused by Giardia duodenalis and Cryptosporidium spp. Read More

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http://dx.doi.org/10.26444/aaem/101576DOI Listing
December 2018
1 Read

Lactoferrin and lactoferricin endocytosis halt Giardia cell growth and prevent infective cyst production.

Sci Rep 2018 Dec 21;8(1):18020. Epub 2018 Dec 21.

Instituto de Investigación Médica Mercedes y Martín Ferreyra, INIMEC - CONICET, Universidad Nacional de Córdoba, Córdoba, 5000, Argentina.

Lactoferrin (LF) is an 80 KDa iron-binding glycoprotein that plays a significant role in the innate immune system and is considered to be an important microbicide molecule. It has been suggested to be effective in the treatment of giardiasis, an intestinal disease caused by the protozoan parasite G. lamblia. Read More

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http://dx.doi.org/10.1038/s41598-018-36563-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6303297PMC
December 2018
2 Reads

Cross-sectional epidemiological investigations of Giardia lamblia in children in Pakistan.

Sao Paulo Med J 2018 Sep-Oct;136(5):449-453

MSc, PhD. Microbiologist and Assistant Professor, Department of Microbiology, Government College University Faisalabad, Faisalabad, Pakistan.

Background: The prevalence of Giardia lamblia in Pakistani children is currently unknown. The aim here was to evaluate the prevalence and risk factors of Giardia lamblia in children exhibiting diarrhea.

Design And Setting: Cross-sectional study at different district healthcare hospitals in Pakistan. Read More

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http://dx.doi.org/10.1590/1516-3180.2018.0350060918DOI Listing
February 2019
9 Reads

Treatment of refractory paediatric giardiasis using secnidazole plus albendazole: a case series.

Infez Med 2018 Dec;26(4):379-384

Academic Paediatric Hospital "Centro Habana", Benjumeda y Morales, Cerro, La Habana, Cuba.

Giardia lamblia, the aetiological agent of human giardiasis, is a frequently identified protozoan infection of the upper small intestine. It mainly affects children and has a wide range of clinical manifestations, from asymptomatic carriage to acute or chronic diarrhoea with dehydration, abdominal pain, nausea, vomiting, excessive flatulence and weight loss. Standard treatment for giardiasis is commonly with 5-nitroimidazole (5-NI) compounds, or nitazoxanide; however, some individuals experience treatment failure. Read More

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December 2018
11 Reads

Prevalence of intestinal parasites and the absence of soil-transmitted helminths in Añatuya, Santiago del Estero, Argentina.

Parasit Vectors 2018 Dec 14;11(1):638. Epub 2018 Dec 14.

Fundación Mundo Sano, Paraguay, 1535, Buenos Aires, Argentina.

Background: Intestinal parasites (IP) have been reported in point studies from different provinces of Argentina. The presence of soil-transmitted helminths (STH) was detected in many of these studies, including varied prevalences of all five species of STH in the north were the climate is more appropriate for transmission. Nonetheless, Argentina lacks a comprehensive prevalence map of STH. Read More

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http://dx.doi.org/10.1186/s13071-018-3232-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6295026PMC
December 2018

Persistent Occurrence of and Subtypes in a Welfare Institute.

Front Microbiol 2018 20;9:2830. Epub 2018 Nov 20.

Key Laboratory of Zoonosis of Ministry of Agriculture, College of Veterinary Medicine, South China Agricultural University, Guangzhou, China.

Few data are available on the transmission dynamics of intestinal protozoa in children in welfare institutes. In this study, fecal specimens were collected from 396 children in a welfare institute in Shanghai, China during December 2011 (207 specimens), June 2012 (78 specimens), and September 2013 (111 specimens), and examined for spp., , and by PCR analysis of the small subunit rRNA, triosephosphate isomerase, and internal transcribed spacer genes, respectively. Read More

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http://dx.doi.org/10.3389/fmicb.2018.02830DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6256193PMC
November 2018
3 Reads

Comparative effect of manuka honey on anaerobic parasitic protozoans with standard drug therapy under conditions: A preliminary study.

Indian J Pharmacol 2018 Jul-Aug;50(4):197-203

Department of Medical Parasitology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Background: From the past five decades, metronidazole and tinidazole have been used for treating nonresistant and resistant giardiasis and trichomoniasis. However, due to the occurrence of drug resistance to standard therapy idealizes us to explore some additional therapies which is cost-effective, easy accessibility, and natural which has least side effects. Manuka honey obtained from is well known for its antibacterial and wound healing properties and is thought to be a better option as an additional therapy. Read More

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http://dx.doi.org/10.4103/ijp.IJP_227_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6234710PMC
March 2019
2 Reads
0.679 Impact Factor

Prolonged duodenal mucosal lymphocyte alterations in patients with and without post infectious functional gastrointestinal disorders after Giardia infection.

J Infect Dis 2018 Nov 30. Epub 2018 Nov 30.

Department of Clinical Science, Faculty of Medicine, University of Bergen, Bergen, Norway.

Objective: Persisting low grade inflammation is suggested to play a role in post-infectious functional gastrointestinal disorders (PI-FGID). The present study examined alterations in duodenal mucosal lymphocytes during and after Giardia gastroenteritis in patients who did, or did not, develop PI-FGID.

Design: Duodenal mucosal intraepithelial lymphocytes (IELs) and lamina propria CD3, CD4, CD8 and CD20 lymphocytes were quantified in 28 chronic giardiasis (CG) patients, 66 patients with persistent abdominal symptoms after acute Giardia infection (PI-FGID), 19 recovered controls (RC) and 16 healthy volunteers (HC). Read More

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http://dx.doi.org/10.1093/infdis/jiy690DOI Listing
November 2018
3 Reads

Molecular genotyping, diversity studies and high-resolution molecular markers unveiled by microsatellites in Giardia duodenalis.

PLoS Negl Trop Dis 2018 11 30;12(11):e0006928. Epub 2018 Nov 30.

Centro de Biologia Molecular e Engenharia Genética (CBMEG), Universidade Estadual de Campinas (UNICAMP), Campinas, São Paulo, Brazil.

Background: Giardia duodenalis (synonyms G. lamblia and G. intestinalis) is an enteric protozoan parasite of a wide range of mammalian hosts, including humans and various domestic and wild animals. Read More

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http://dx.doi.org/10.1371/journal.pntd.0006928DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6291164PMC
November 2018
1 Read

Treatment-refractory giardiasis: challenges and solutions.

Infect Drug Resist 2018 24;11:1921-1933. Epub 2018 Oct 24.

Norwegian National Advisory Unit on Tropical Infectious Diseases, Department of Medicine, Haukeland University Hospital, Bergen, Norway.

is the commonest parasitic diarrheal pathogen affecting humans and a frequent cause of waterborne/foodborne parasitic diseases worldwide. Prevalence of giardiasis is higher in children, living in poor, low hygiene settings in developing countries, and in travelers returning from highly endemic areas. The clinical picture of giardiasis is heterogeneous, with high variability in severity of clinical disease. Read More

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http://dx.doi.org/10.2147/IDR.S141468DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6207226PMC
October 2018
2 Reads

Effect of Hydroalcoholic Extract on Cysts Compared with Metronidazole in Vitro.

Iran J Parasitol 2018 Jul-Sep;13(3):486-492

Dept. of Pharmacology and Toxicology, Urmia Branch, Islamic Azad University, Urmia, Iran.

Background: Giardiasis, an intestinal infection, is made by the flagellate protozoan and on the other hand, positive effects of plants derivatives, especially phenolic derivatives, against giardiasis. The effect of (OV) hydroalcoholic extract is still uninvestigated. Thus, this study was conducted to evaluate the effect of OV hydroalcoholic extract on cysts compared with metronidazole in vitro. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6243170PMC
November 2018
11 Reads

Design, synthesis and biological evaluation of 2-nitroimidazopyrazin-one/-es with antitubercular and antiparasitic activity.

J Med Chem 2018 Nov 23. Epub 2018 Nov 23.

Tuberculosis and parasitic diseases, such as giardiasis, amebiasis, leishmaniasis and trypanosomiasis, all urgently require improved treatment options. Recently, it has been shown that anti-tubercular bicyclic nitroimidazoles such as pretomanid and delamanid have potential as repurposed therapeutics for the treatment of visceral leishmaniasis. Here we show that pretomanid also possesses potent activity against Giardia lamblia and Entamoeba histolytica, thus expanding the therapeutic potential of nitroimidazo-oxazines. Read More

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http://dx.doi.org/10.1021/acs.jmedchem.8b01578DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311682PMC
November 2018
2 Reads

Giardia duodenalis in small animals and their owners in Germany: A pilot study.

Zoonoses Public Health 2019 02 20;66(1):117-124. Epub 2018 Nov 20.

Small Animal Clinic, Faculty of Veterinary Medicine, Freie Universität Berlin, Berlin, Germany.

Giardia duodenalis is a relevant gastrointestinal protozoan pathogen of humans and animals. This species complex consists of eight genetically different assemblages. Assemblages A and B are pathogenic to humans and pets, thus confer zoonotic potential. Read More

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http://dx.doi.org/10.1111/zph.12541DOI Listing
February 2019
13 Reads

Cleavage specificity of recombinant Giardia intestinalis cysteine proteases: Degradation of immunoglobulins and defensins.

Mol Biochem Parasitol 2019 Jan 17;227:29-38. Epub 2018 Nov 17.

Department of Cell and Molecular Biology, BMC, Box 596, Uppsala University, SE-751 24, Uppsala, Sweden. Electronic address:

Giardia intestinalis is a protozoan parasite and the causative agent of giardiasis, a common diarrheal disease. Cysteine protease (CP) activities have been suggested to be involved in Giardia's pathogenesis and we have recently identified and characterized three secreted Giardia CPs; CP14019, CP16160 and CP16779. Here we have studied the cleavage specificity of these CPs using substrate phage display and recombinant protein substrates. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01666851183009
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http://dx.doi.org/10.1016/j.molbiopara.2018.10.004DOI Listing
January 2019
13 Reads

Highly Potent 1-1,2,3-Triazole-Tethered Isatin-Metronidazole Conjugates Against Anaerobic Foodborne, Waterborne, and Sexually-Transmitted Protozoal Parasites.

Front Cell Infect Microbiol 2018 30;8:380. Epub 2018 Oct 30.

Department of Chemistry, Guru Nanak Dev University, Amritsar, India.

Parasitic infections like amebiasis, trichomoniasis, and giardiasis are major health threats in tropical and subtropical regions of the world. Metronidazole (MTZ) is the current drug of choice for amebiasis, giardiasis, and trichomoniasis but it has several adverse effects and potential resistance is a concern. In order to develop alternative antimicrobials, a library of 1-1,2,3-triazole-tethered metronidazole-isatin conjugates was synthesized using Huisgen's azide-alkyne cycloaddition reaction and evaluated for their amebicidal, anti-trichomonal, and anti-giardial potential. Read More

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https://www.frontiersin.org/article/10.3389/fcimb.2018.00380
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http://dx.doi.org/10.3389/fcimb.2018.00380DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6218680PMC
October 2018
7 Reads

Development of Molecular Diagnosis Using Multiplex Real-Time PCR and T4 Phage Internal Control to Simultaneously Detect Cryptosporidium parvum, Giardia lamblia, and Cyclospora cayetanensis from Human Stool Samples.

Korean J Parasitol 2018 Oct 31;56(5):419-427. Epub 2018 Oct 31.

Department of Parasitology and Tropical Medicine, Seoul National University College of Medicine, and Institute of Endemic Diseases, Seoul National University Medical Research Center, Seoul 03080, Korea.

This study aimed to develop a new multiplex real-time PCR detection method for 3 species of waterborne protozoan parasites (Cryptosporidium parvum, Giardia lamblia, and Cyclospora cayetanensis) identified as major causes of traveler's diarrhea. Three target genes were specifically and simultaneously detected by the TaqMan probe method for multiple parasitic infection cases, including Cryptosporidium oocyst wall protein for C. parvum, glutamate dehydrogenase for G. Read More

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http://dx.doi.org/10.3347/kjp.2018.56.5.419DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6243187PMC
October 2018
2 Reads

A spatial analysis of giardiasis and cryptosporidiosis in relation to public water supply distribution in North West England.

Spat Spatiotemporal Epidemiol 2018 11 13;27:61-70. Epub 2018 Oct 13.

CHICAS, Lancaster Medical School, Lancaster University, LA1 4YW United Kingdom.

Giardia and Cryptosporidium are both waterborne parasites and leading causes of gastroenteritis. Although specimens from diarrhoeic patients are routinely examined for Cryptosporidium, they are often not examined for Giardia so many cases go undiagnosed. Since 2002, all faecal specimens in Central Lancashire have been tested for infection with Giardia and Cryptosporidium. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18775845173005
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http://dx.doi.org/10.1016/j.sste.2018.09.002DOI Listing
November 2018
21 Reads

A Rare Complication of Giardiasis in Children: Protein-losing Enteropathy.

Pediatr Infect Dis J 2018 Dec;37(12):e345-e347

From the Division of Pediatric Gastroenterology, Hepatology and Nutrition.

Protein-losing enteropathy may develop as a complication of a wide spectrum of diseases. Three cases of giardiasis that presented with acute onset of hypoalbuminemia were documented, and resolution of protein loss after treatment was also confirmed. Thus, chronic enteric infections should be considered as an etiology of severe intestinal protein loss, particularly in children. Read More

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http://dx.doi.org/10.1097/INF.0000000000002025DOI Listing
December 2018
16 Reads

Occurrence and Multilocus Genotyping of in Yunnan Black Goats in China.

Biomed Res Int 2018 10;2018:4601737. Epub 2018 Oct 10.

State Key Laboratory of Veterinary Etiological Biology, Key Laboratory of Veterinary Parasitology of Gansu Province, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, Gansu Province 730046, China.

is an important zoonotic parasite which can parasitize in the intestines of humans and various animals. However, the information about the prevalence and genetic diversity of in goats in China is limited. It is yet to be known whether Yunnan black goats, a unique goat breed in subtropical Yunnan province, southwestern China, are infected with Thus, a total of 907 fecal samples were collected from Yunnan black goats in five regions in Yunnan province, to estimate the prevalence and genotypes of using a PCR-based approach. Read More

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https://www.hindawi.com/journals/bmri/2018/4601737/
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http://dx.doi.org/10.1155/2018/4601737DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6199876PMC
February 2019
10 Reads

Giardia: an under-reported foodborne parasite.

Int J Parasitol 2019 Jan 1;49(1):1-11. Epub 2018 Nov 1.

College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China.

Foodborne zoonotic pathogens are a serious public health issue and result in significant global economic losses. Despite their importance to public health, epidemiological data on foodborne diseases including giardiasis caused by the enteric parasite, Giardia duodenalis, are lacking. This parasite is estimated to cause ∼28. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00207519183024
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http://dx.doi.org/10.1016/j.ijpara.2018.07.003DOI Listing
January 2019
13 Reads

Improving basic skills in celiac-like disease diagnosis: a case report.

BMC Gastroenterol 2018 Nov 3;18(1):162. Epub 2018 Nov 3.

Gastroenterology and Gastrointestinal Endoscopy Unit, Sant'Andrea University Hospital, "Sapienza" University of Rome, Rome, Italy.

Background: The diagnosis of Coeliac disease (CD) requires a combination of sign/symptoms, positivity of specific antibodies and duodenal histological evidence of villous atrophy. Duodenal villous atrophy, despite representing the CD landmark, is not specific since it is found in many gastrointestinal disorders. Giardiasis is one of the most common human intestinal protozoan infestations in industrialized countries whose histological duodenal mucosa damage could mimic that of CD. Read More

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https://bmcgastroenterol.biomedcentral.com/articles/10.1186/
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http://dx.doi.org/10.1186/s12876-018-0894-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6215663PMC
November 2018
14 Reads

Acute phase response in organic lambs associated with colostrum serum amyloid A, weight gain, and Cryptosporidium and Giardia infections.

Res Vet Sci 2018 Dec 29;121:117-123. Epub 2018 Oct 29.

Institute of Veterinary Medicine and Animal Sciences, Estonian University of Life Sciences, Kreutzwaldi 62, Tartu 51014, Estonia.

In neonatal period, lamb's immune system goes through rapid adaptation to the extra-uterine environment. Success of this process can influence the animal's future performance and, thus, the quantitative assessment of it would greatly benefit sheep producers. The current study was conducted to investigate the acute phase response (APR) (measured through serum amyloid A (SAA), haptoglobin (Hp) and albumin (ALB)) in relation to later life growth (measured at 122 days of age), and naturally occurring Cryptosporidium and Giardia infections in neonatal lambs grown in organic farm. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00345288183047
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http://dx.doi.org/10.1016/j.rvsc.2018.10.013DOI Listing
December 2018
6 Reads

Activity of Thioallyl Compounds From Garlic Against Trophozoites and in Experimental Giardiasis.

Front Cell Infect Microbiol 2018 15;8:353. Epub 2018 Oct 15.

Departamento de Genética y Biología Molecular, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, Mexico City, Mexico.

Fresh aqueous extracts (AGEs) and several thioallyl compounds (TACs) from garlic have an important antimicrobial activity that likely involves their interaction with exposed thiol groups at single aminoacids or target proteins. Since these groups are present in trophozoites, in this work we evaluated the anti-giardial activity of AGE and several garlic's TACs. susceptibility assays showed that AGE affected trophozoite viability initially by a mechanism impairing cell integrity and oxidoreductase activities while diesterase activities were abrogated at higher AGE concentrations. Read More

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http://dx.doi.org/10.3389/fcimb.2018.00353DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6196658PMC
October 2018
16 Reads

Molecular detection and genotyping of pathogenic protozoan parasites in raw and treated water samples from southwest Colombia.

Parasit Vectors 2018 Oct 26;11(1):563. Epub 2018 Oct 26.

Grupo de Investigaciones Microbiológicas-UR (GIMUR), Programa de Biología, Facultad de Ciencias Naturales y Matemáticas, Universidad del Rosario, 110111, Bogotá, Colombia.

Background: Protozoan parasites such as Giardia duodenalis, Cryptosporidium spp., Cyclospora cayetanensis, Toxoplasma gondii and Entamoeba histolytica represent a great challenge to the systems producing water for human consumption because their cystic forms are persistent in the environment and resist to the disinfection methods conventionally used for their control. In this study, we investigated the presence of these protozoan pathogens in both raw and treated water samples used for the production of drinking water in Nariño Department, southwest Colombia. Read More

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https://parasitesandvectors.biomedcentral.com/articles/10.11
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http://dx.doi.org/10.1186/s13071-018-3147-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6203992PMC
October 2018
14 Reads

Genetics and serology of celiac disease during giardiasis.

Scand J Gastroenterol 2018 Oct - Nov;53(10-11):1427. Epub 2018 Oct 24.

b Genetic, Cardiovascular and Nutritional Diseases Laboratory , Setif-1 University , Setif , Algeria.

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http://dx.doi.org/10.1080/00365521.2018.1508612DOI Listing
February 2019
3 Reads
2.329 Impact Factor

The Influence of Climate and Livestock Reservoirs on Human Cases of Giardiasis.

Ecohealth 2018 Oct 22. Epub 2018 Oct 22.

Department of Population Medicine, Ontario Veterinary College, University of Guelph, 50 Stone Road East, Guelph, ON, N1G 2W1, Canada.

Giardia duodenalis is an intestinal parasite which causes diarrhoeal illness in people. Zoonotic subtypes found in livestock may contribute to human disease occurrence through runoff of manure into multi-use surface water. This study investigated temporal associations among selected environmental variables and G. Read More

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http://dx.doi.org/10.1007/s10393-018-1385-7DOI Listing
October 2018
2 Reads

Giardia duodenalis in the UK: current knowledge of risk factors and public health implications.

Parasitology 2019 Apr 15;146(4):413-424. Epub 2018 Oct 15.

The Moredun Research Institute,Pentlands Science Park,Bush Loan,Penicuik,Scotland EH26 0PZ,UK.

Giardia duodenalis is a ubiquitous flagellated protozoan parasite known to cause giardiasis throughout the world. Potential transmission vehicles for this zoonotic parasite are both water and food sources. As such consumption of water contaminated by feces, or food sources washed in contaminated water containing parasite cysts, may result in outbreaks. Read More

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http://dx.doi.org/10.1017/S0031182018001683DOI Listing
April 2019
2 Reads

Endoscopic findings in patients with familial Mediterranean fever and dyspeptic symptoms.

Prz Gastroenterol 2018 5;13(3):234-241. Epub 2018 Jul 5.

Department of Paediatric Allergy and Immunology, Medical Faculty, Cukurova University Sarıcam, Adana, Turkey.

Aim: The aim of the study was to evaluate the clinical, endoscopic, histopathological, laboratory, and imaging findings of patients with familial Mediterranean fever (FMF) presenting with dyspeptic symptoms.

Material And Methods: Endoscopy was performed in 28 patients with FMF undergoing colchicine therapy, who presented to our hospital between 2012 and 2014 with abdominal pain, diarrhoea, and dyspeptic complaints. Upper gastrointestinal system endoscopy was performed in all patients; 16 of these underwent colonoscopy. Read More

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https://www.termedia.pl/doi/10.5114/pg.2018.76954
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http://dx.doi.org/10.5114/pg.2018.76954DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6173081PMC
July 2018
19 Reads

Ocular Parasitosis Caused by Protozoan Infection during Travel: Focus on Prevention and Treatment.

Int J Prev Med 2018 17;9:79. Epub 2018 Sep 17.

Health Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran.

International travel is rising quickly worldwide. Many people travel to tropical and subtropical areas, where there has been increasing exposure of travelers to infectious pathogens. Ocular parasitic infections are more prevalent in these geographical areas and they can lead to morbidity and mortality, often due to late or misdiagnosis due to the unfamiliarity of health staff with these diseases. Read More

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http://dx.doi.org/10.4103/ijpvm.IJPVM_161_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6151969PMC
September 2018
16 Reads

Stunting, Beyond Acute Diarrhoea: Giardia Duodenalis, in Cambodia.

Nutrients 2018 Oct 3;10(10). Epub 2018 Oct 3.

United Nations Children's Fund (UNICEF), Integrated Early Childhood Development, Exchange Square, 5th Floor, No. 19&20, Street 106, Sangkat Wat Phnom, Khan Daun Penh, Phnom Penh 12100, Cambodia.

Background: The adverse outcomes of malnutrition on the development of a child are well acknowledged as are the broad variety of contextual factors that may impact child nutritional status. Adequate nutrient intake and the adoption of appropriate water, sanitation and hygiene measures are largely documented for their positive influence on health. Improved sanitation and protection from human feces can significantly lower the incidence of diarrhea and environmental enteropathy. Read More

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http://www.mdpi.com/2072-6643/10/10/1420
Publisher Site
http://dx.doi.org/10.3390/nu10101420DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6213534PMC
October 2018
13 Reads

Giardiasis: Characteristics, Pathogenesis and New Insights About Treatment.

Curr Top Med Chem 2018 ;18(15):1287-1303

Departamento de Ingenieria. Area Farmacia y Tecnologia Farmaceutica. Universidad Miguel Hernández de Elche, Elche, Spain.

Giardia intestinalis infection causes enterocytes damage and loss of brush border of the epithelial cells of the intestine that leads to shortening of microvilli and altered epithelial barrier function. This pathology results in aqueous diarrhoea, steatorrhea, nausea, abdominal pain, vomiting and weight loss. However, most infections are asymptomatic. Read More

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http://dx.doi.org/10.2174/1568026618666181002095314DOI Listing
February 2019
6 Reads

Epidemiology and associated risk factors of giardiasis in a peri-urban setting in New South Wales Australia.

Epidemiol Infect 2018 Sep 28:1-9. Epub 2018 Sep 28.

Public Health Unit,South Western Sydney Local Health District,Liverpool,Australia.

Giardiasis is one of the most important non-viral causes of human diarrhoea. Yet, little is known about the epidemiology of giardiasis in the context of developed countries such as Australia and there is a limited information about local sources of exposure to inform prevention strategies in New South Wales. This study aimed to (1) describe the epidemiology of giardiasis and (2) identify potential modifiable risk factors associated with giardiasis that are unique to south-western Sydney, Australia. Read More

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http://dx.doi.org/10.1017/S0950268818002637DOI Listing
September 2018
4 Reads

Five facts about Giardia lamblia.

PLoS Pathog 2018 09 27;14(9):e1007250. Epub 2018 Sep 27.

Laboratory of Molecular Parasitology, Institute of Parasitology, University of Zurich (ZH), Zurich, Switzerland.

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http://dx.doi.org/10.1371/journal.ppat.1007250DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6160191PMC
September 2018
1 Read