3,900 results match your criteria Giant Cell Tumor Imaging

Surgical management of 144 diffuse-type TGCT patients in a single institution: A 20-year cohort study.

J Surg Oncol 2022 Jun 23. Epub 2022 Jun 23.

Department of Orthopedic Surgery, Leiden University Medical Center, Leiden, The Netherlands.

Background And Objectives: Surgery is the mainstay of treatment for tenosynovial giant cell tumors (TGCTs). However, achieving a cure through surgery alone remains challenging, especially for the diffuse-type (D-TGCT).

Methods: Our goal was to describe the surgical management of patients with D-TGCT related to large joints, treated between 2000 and 2020. Read More

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[Experience with Denosumab in central giant-cell granuloma].

Andes Pediatr 2022 Apr;93(2):247-252

Hospital Universitario Central de Asturias, Oviedo, España.

Introduction: Central Giant Cell Granuloma is an infrequent bone lesion located mainly in the maxillary bone. The main treatment is surgery with wide margins, so it sometimes causes great morbidity and esthetic al terations. Denosumab, a RANK-ligand inhibitor monoclonal antibody, has been presented as a valid therapeutic alternative in the treatment of these lesions. Read More

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The Evaluation of Correlation Between Serum PTH and Dentoskeletal Changes in Panoramic Imaging of Hemodialysis Patients.

Iran J Kidney Dis 2022 May;16(3):203-208

Department of Maxillofacial Radiology, School of Dentistry, Guilan University of Medical Sciences, Rasht, Iran.

Introduction: This study aimed to investigate the relationship between serum levels of PTH and dental and bone changes in the panoramic view of hemodialysis patients.

Methods: Out of 236 patients with end-stage kidney disease (ESKD) who were hospitalized in two hemodialysis centers, 68 ones were selected and concerning their PTH serum levels, they were assigned to case group (PTH > 300 pg/mL) and control group (150 < PTH < 300 pg/mL). Patients in both groups had undergone dialysis for at least 6 months. Read More

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Aneurysmal bone cyst secondary to giant cell tumor of the extremities: a case series of 30 patients.

Am J Transl Res 2022 15;14(5):3198-3206. Epub 2022 May 15.

Department of Orthopedics, The First Affiliated Hospital of Guangxi Medical University Nanning, Guangxi, China.

The purpose was to investigate the clinical features, diagnosis, treatment, and prognosis of aneurysmal bone cyst (ABC) secondary to giant cell tumors (GCT) of the extremities. Data from patients with ABC secondary to GCT of the extremities were obtained from the medical records. Clinical features, imaging findings, pathologic diagnosis, surgical methods, and prognosis were analyzed. Read More

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Recent advances in the diagnosis and therapy of large vessel vasculitis.

Pol Arch Intern Med 2022 Jun 6. Epub 2022 Jun 6.

Large vessel vasculitis (LVV), including Takayasu arteritis (TAK) and giant cell arteritis (GCA), causes granulomatous vascular inflammation mainly in large vessels, and is the most common primary vasculitis in adults. Vascular inflammation may evoke many clinical features including vision impairment, stroke, limb ischemia, and aortic aneurysms. The best way to diagnose LVV is to combine medical history, physical examination, various laboratory tests, and imaging modalities. Read More

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A Rare Case of Primary Cardiac Lymphoma Presenting with Acute Myocardial Infarction: to Be Happy or to Be Sorry?

Turk Kardiyol Dern Ars 2022 06;50(4):300-303

Department of Cardiovascular Surgery, Bakırköy Dr. Sadi Konuk Training and Research Hospital, İstanbul, Turkey.

Among primary malignant tumors of the heart, primary cardiac lymphomas are extremely rare. Early diagnosis is crucial in primary cardiac lymphoma cases as its non-specific symp- toms often lead to delayed diagnosis and poor prognosis. In this case report, we presented a challenging case of primary cardiac lymphoma that was noticed during echocardiography of a patient admitted with acute myocardial infarction. Read More

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Xanthogranulomatous epithelial tumors and keratin-positive giant cell-rich soft tissue tumors: two aspects of a single entity with frequent HMGA2-NCOR2 fusions.

Mod Pathol 2022 Jun 11. Epub 2022 Jun 11.

Department of Pathology and Immunology, Division of Anatomic Pathology, Washington University School of Medicine, St. Louis, MO, USA.

Xanthogranulomatous epithelial tumor (XGET) and keratin-positive giant cell-rich soft tissue tumor with HMGA2-NCOR2 fusion (KPGCT) are two recently described neoplasms with both distinct and overlapping clinical and histopathologic features. We hypothesized that XGET and KPGCT may be related and represent a histologic spectrum of a single entity. To test this, we sought to characterize the clinical, radiographic, immunohistochemical, ultrastructural and molecular features of additional tumors with features of XGET and/or KPGCT, which we refer to descriptively as keratin-positive xanthogranulomatous/giant cell-rich tumors (KPXG/GCT). Read More

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Arthroscopic Synovectomy for Tenosynovial Giant Cell Tumor/Pigmented Villonodular Synovitis in the Posterior Knee Using the Posterior Trans-Septal Portal Technique.

JBJS Essent Surg Tech 2022 Jan-Mar;12(1). Epub 2022 Mar 21.

Department of Orthopaedics and Rehabilitation, Yale School of Medicine, New Haven, Connecticut.

Tenosynovial giant cell tumor (T-GCT) and pigmented villonodular synovitis (PVNS) are interchangeable terms for an uncommon benign proliferation of synovial tissue. Although neoplastic and inflammatory origins have been hypothesized, the etiology of this condition is unknown. There is controversy regarding surgical treatment, as the open and arthroscopic approaches to synovectomy have shown comparable reported outcomes in the literature. Read More

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Imaging of Paget's Disease of Bone.

Radiol Clin North Am 2022 Jul;60(4):561-573

Department of Radiology, University of Miami Miller School of Medicine, Jackson Memorial Hospital, Miami, FL 33136, USA.

Paget's disease is a metabolic bone disorder affecting the elderly and characterized by bone resorption followed by compensatory bone formation. Radiography is the imaging modality of choice for the diagnosis whereas bone scintigraphy helps stage the extent of the disease and assess response to treatment. MRI and CT are important imaging methods in the assessment of complications and surgical planning. Read More

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Tenosynovial Giant Cell Tumor Mimicking Acute Septic Arthritis of the Hip: A Case Report.

J Am Acad Orthop Surg Glob Res Rev 2022 Jun 6;6(6). Epub 2022 Jun 6.

From the Weill Cornell Medical College, New York, NY (Honig) and the Department of Orthopaedic Surgery, The Johns Hopkins University, Baltimore, MD (Dr. Harris, Dr. Sabharwal, Dr. Levin, and Dr. Honcharuk).

A 12-year-old boy presented to the pediatric emergency department with a 5-day history of atraumatic, progressively worsening right hip pain and inability to ambulate. He was afebrile and had elevated inflammatory markers (Erythrocyte Sedimentation Rate [ESR]: 42 mm/hr, C-Reactive Protein [CRP]: 6.6 mg/dL) with a normal white blood cell count of 6050 cells/mm3. Read More

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Malignant giant cell tumor of toe: A case report and review of literature.

Medicine (Baltimore) 2022 Jun 3;101(22):e29471. Epub 2022 Jun 3.

Department of Orthopedic Surgery, Kindai University Hospital, Osaka-Sayama City, Japan.

Introduction: A giant cell tumor of soft tissue (GCST) is a benign soft tissue tumor that often occurs subcutaneously in the extremities. Rare cases of malignant GCST have been reported, but its pathogenesis remains unclear.

Patients Concerns: We report a case of a 68-year-old man who noticed a painless mass on his second toe one and a half years ago. Read More

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Gliosarcoma with unusual glial components: Two case reports.

Neuropathology 2022 May 29. Epub 2022 May 29.

Department of Neuropathology, St Mary's Hospital, Fukuoka, Japan.

Gliosarcoma is characterized by the presence of alternating lesions of glial and mesenchymal components. Although many mesenchymal components have been reported, there are few reports on glial components. We here report two cases of gliosarcoma. Read More

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Surgical Treatment Patterns, Healthcare Resource Utilization, and Economic Burden in Patients with Tenosynovial Giant Cell Tumor Who Underwent Joint Surgery in the United States.

J Health Econ Outcomes Res 2022 4;9(1):68-74. Epub 2022 Mar 4.

Rothman Institute and Fox Chase Cancer Center.

Tenosynovial giant cell tumors (TGCT) are rare and locally aggressive neoplasms in synovium, bursae, and tendon sheaths, which cause pain, joint dysfunction, and damage to the affected joints. To evaluate the surgical patterns and economic burden among patients with TGCT who underwent joint surgery in the United States. Patients newly diagnosed with TGCT, aged 18-64 years, who underwent joint surgery post-TGCT diagnosis were identified from the OptumHealth Care Solutions, Inc database (Q1/1999-Q1/2017). Read More

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Radiologic and clinical changes after denosumab treatment for giant cell tumors of the mobile spine: a quantitative study.

Insights Imaging 2022 May 26;13(1):93. Epub 2022 May 26.

Department of Orthopaedics, Peking University Third Hospital, No. 49 North Garden Road, Haidian District, Beijing, 100191, China.

Objectives: To analyze the radiologic and clinical changes after denosumab treatment in patients with giant cell tumors (GCTs) in the mobile spine.

Methods: Clinical data and images by computed tomography and magnetic resonance imaging at a single center were retrospectively reviewed before and after denosumab treatment.

Results: Pre- and post-treatment data from 24 patients were evaluated. Read More

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Undifferentiated carcinoma of the pancreas with osteoclast like giant cells: Literature review with CT/MR imaging findings in 3 cases.

Radiol Case Rep 2022 Jul 13;17(7):2529-2533. Epub 2022 May 13.

Department of Radiology, Sir Run Run Shaw hospital, Zhejiang University School of Medicine, Hangzhou City 310016, Zhejiang Province, China.

Undifferentiated carcinoma with osteoclast-like giant cells of pancreas (UCOGCP) is a relatively rare tumor worldwide. Its accurate preoperative diagnosis is extremely difficult. Because the mass is usually large and closely related to neighboring structures, it is difficult to locate the tumor and it is often misdiagnosed as pancreatic cancer, neuroendocrine tumor or gastrointestinal stromal tumor. Read More

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Giant malignant sacrococcygeal germ cell tumor in a newborn: A rare case report.

Radiol Case Rep 2022 Jul 7;17(7):2416-2423. Epub 2022 May 7.

Department of Radiology - "AORN Santobono Pausilipon", Pediatric Hospital, Naples, Italy.

Malignant germ cell tumors constitute about 3%-4% of all neoplasms occurring before the age of 15. They arise in the ovaries, the testes, and in several other locations, including the lower back, the chest, the brain, and the abdomen. In infants and young children, the sacrococcygeal region is the most common site for extragonadal germ cell tumors, and teratomas account for the vast majority of sacrococcygeal germ cell tumors. Read More

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Risk factors of fracture following curettage for bone giant cell tumors of the extremities.

BMC Musculoskelet Disord 2022 May 19;23(1):477. Epub 2022 May 19.

Department of Orthopaedic Oncology, IRCCS Istituto Ortopedico Rizzoli, Via Pupilli 1, 40136, Bologna, Italy.

Background: Following curettage of giant cell tumor of bone (GCTB), it is common to fill the cavity with polymethylmethacrylate (PMMA) bone cement, bone allograft, or artificial bone to maintain bone strength; however, there is a 2-14% risk of postoperative fractures. We conducted this retrospective study to clarify the risk factors for fractures after curettage for GCTB of the extremities.

Methods: This study included 284 patients with GCTBs of the extremities who underwent curettage at our institutions between 1980 and 2018 after excluding patients whose cavities were not filled with anything or who had additional plate fixation. Read More

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Giant Cell Tumour Of The Occipital Bone In A 13-Year Old Male.

J Ayub Med Coll Abbottabad 2022 Apr-Jun;34(2):378-380

3Department of Radiology, Mayo Clinic, Florida, USA.

Giant Cell Tumours (GCT) are usually found at the extremities of the long bones and their presence in the skull being less than 1%. In the skull, sphenoidal bone and temporal bone are the commonest sites. There have been very few reports of GCTs of the occipital bone. Read More

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Dumbbell-type tenosynovial giant cell tumor of the buttocks: a report of two cases.

Transl Cancer Res 2022 Apr;11(4):952-958

Department of Orthopaedics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Background: Tenosynovial giant cell tumor (TSGCT) is a benign tumor derived from the synovium of the joints, bursa, and tendon sheaths, which is mainly located around the tendon sheath of hand and foot. Extra-articular TSGCT are relatively rare and are mainly found in the soft tissue around the large joint. They are rarer when located purely intramuscular or subcutaneous, and mostly in the lower extremities. Read More

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CD44+ and CD133+ Non-Small Cell Lung Cancer Cells Exhibit DNA Damage Response Pathways and Dormant Polyploid Giant Cancer Cell Enrichment Relating to Their p53 Status.

Int J Mol Sci 2022 Apr 28;23(9). Epub 2022 Apr 28.

School of Biological and Medical Physics, Moscow Institute of Physics and Technology, 141700 Dolgoprudny, Russia.

Cancer stem cells (CSCs) play a critical role in the initiation, progression and therapy relapse of many cancers including non-small cell lung cancer (NSCLC). Here, we aimed to address the question of whether the FACS-sorted CSC-like (CD44 + &CD133 +) vs. non-CSC (CD44-/CD133- isogenic subpopulations of p53wt A549 and p53null H1299 cells differ in terms of DNA-damage signaling and the appearance of "dormant" features, including polyploidy, which are early markers (predictors) of their sensitivity to genotoxic stress. Read More

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Total neurological recovery after surgical decompression and treatment with denosumab of large unresectable spinal giant cell tumour expanding to mediastinum.

BMJ Case Rep 2022 May 12;15(5). Epub 2022 May 12.

Orthopaedic Surgery, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand

There is a controversy over the medical treatment of unresectable spinal giant cell tumour (GCT) regarding dosing and duration. We studied a spinal GCT case that had expanded to the thoracic spinal canal and mediastinum and was successfully treated by surgical decompression and denosumab. A woman in her 30s presented with weakness in both the lower extremities. Read More

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Primary giant cell tumour of the breast with recurrence: A rare case report.

SA J Radiol 2022 20;26(1):2393. Epub 2022 Apr 20.

Department of Radiology, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa.

Giant cell tumour (GCT) arising from the soft tissues of the breast is a rare disease with only eight cases previously reported in the literature. We present a case of histologically proven GCT of the breast, which demonstrated recurrence a few months after resection. Read More

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Localized Giant Cell Tumor of the Tendon Sheath of the Upper Cervical Spine: A Case Report.

Neurol India 2022 Mar-Apr;70(2):764-766

Department of Neurosurgery, West China Hospital, Sichuan University, Ghana.

Introduction: Giant cell tumor of the tendon sheath (GCTTS) is commonly seen in the appendicular skeleton, and rarely arises from the axial skeleton. We describe a rare case of GCTTS in an adolescent in the upper cervical spine.

Case Presentation: A previously healthy 16-year-old boy presented with a 6-month history of numbness of right upper extremity, and had experienced a neck pain 4 months ago. Read More

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Intra-articular Neoplasms and Masslike Lesions of the Knee: Emphasis on MR Imaging.

Magn Reson Imaging Clin N Am 2022 May 13;30(2):339-350. Epub 2022 Apr 13.

Department of Radiology, UCSD Health System, University of California, HCOP MRI, 408 Dickinson Street, San Diego, CA 92103-8226, USA.

Intra-articular masses affecting the knee joint are uncommon lesions that encompass a range of neoplastic and nonneoplastic disorders. A joint mass limited to a single articulation is most commonly related to neoplastic or focal proliferative disease, whereas masses affecting multiple articulations are typically caused by underlying inflammatory arthritides, metabolic abnormalities, or systemic deposition disorders. This article focuses on those masses that present in a monoarticular fashion, emphasizing the lesions that most commonly affect the knee joint. Read More

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Clinical and radiological outcomes of combined modular prothesis and cortical strut for revision proximal femur in giant cell tumor of bone patients.

J Orthop Surg (Hong Kong) 2022 01;30(1):10225536221095202

Department of Orthopedics, The Second Xiangya Hospital of Central South University, Changsha, China.

Background: Femoral bone deficiency is a challenging problem in revision proximal femoral replacement. The purpose of this study is to evaluate the clinical and radiological outcomes of revision proximal femoral replacement as a salvage treatment for severe bone loss after oncologic proximal replacement surgery in patient with benign giant cell tumor of bone.

Methods: 16 patients (6 men and 10 women) were included in this retrospective study, with a mean age of 46. Read More

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January 2022

Spontaneous rupture of an undifferentiated carcinoma with osteoclast-like giant cells of the pancreas presenting as intra-abdominal bleeding: a case report.

Surg Case Rep 2022 Apr 29;8(1):79. Epub 2022 Apr 29.

Department of Surgery, Kindai University Nara Hospital, 1248-1 Otoda-cho, Ikoma, Nara, 630-0293, Japan.

Background: Undifferentiated carcinoma is a very rare histologic subtype, representing only 0.8% to 5.7% of all pancreatic exocrine neoplasms. Read More

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Rare malignant melanotic nerve sheath tumors of the upper limb nerves: utility of high-frequency ultrasonography in preoperative imaging.

Skeletal Radiol 2022 Apr 28. Epub 2022 Apr 28.

Department of Ultrasound, Xijing Hospital, the Fourth Military Medical University, No. 127 Changle West Road, Xi'an, 710032, China.

Melanotic nerve sheath tumor (MNST) is a rare variant of schwannoma. Here, we report an unusual case of multiple MNST lesions located in the upper limb nerves. The patient presented with a mass on the left wrist in 2016 and another mass on the left thumb in 2017. Read More

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Intramural Gastric Metastasis: A Rare Presentation of Esophageal Squamous Cell Carcinoma.

J Med Ultrasound 2022 Jan-Mar;30(1):47-49. Epub 2021 Aug 21.

Department of Pathology, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India.

Intramural gastric metastasis of the esophageal carcinoma, excluding the direct extension of primary neoplasm, is rare. However, intramural metastasis to the esophagus is commoner than this. These are more common in squamous cell carcinoma variant. Read More

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The clinical challenges and dilemma in the management of uncommon maxillary sinus tumors - A report of two cases.

J Oral Maxillofac Pathol 2022 Feb 28;26(Suppl 1):S116-S118. Epub 2022 Feb 28.

Department of Pathology, Tata Memorial Center, Homi Bhabha National Institute, Mumbai, Maharashtra, India.

Maxillary sinus is the common site for the nose and paranasal sinus tumors with diverse histopathological types and the treatment for each may differ. Making a histopathological diagnosis on occasion can be challenging. We had two patients presenting with upper alveolus growth in whom establishing the histopathological diagnosis was challenging. Read More

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February 2022

Soft tissue aneurysmal bone cyst of left hemithorax: An extremely rare case.

Indian J Pathol Microbiol 2022 Apr-Jun;65(2):452-454

Department of Surgical Oncology, The Gujarat Cancer and Research Institute, New Civil Hospital Campus, Asarwa, Ahmedabad, Gujarat, India.

Aneurysmal bone cyst (ABC) is a benign expansile cystic lesion that can affect any bone of the skeleton, especially the femur, tibia, and humerus. Lesions with histologic features of an ABC can be originated within soft tissue in exceedingly rare cases. Extra-skeletal ABC may mimic a variety of benign and malignant lesions and can be confused with other common or rare giant cell-rich tumors of soft tissue. Read More

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