3,680 results match your criteria Giant Cell Tumor Imaging

Ovarian dysgerminoma with pseudo-Meigs syndrome: A case report.

Medicine (Baltimore) 2021 Jun;100(23):e26319

Forensic and Pathology Laboratory, Jiaxing University Medical College, Jiaxing, ZJ, China.

Rationale: Dysgerminoma is a rare malignant tumor of the ovary, more frequently occurring in young women. The main signs of pseudo-Meigs syndrome (PMS) are ascites and hydrothorax accompanying benign or malignant ovarian tumors (no fibroma or fibroma-like tumor).

Patient Concerns: A 19-year-old woman with fever and chest tightness for 2 days. Read More

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A unique case of adamantinoma-like Ewing sarcoma in the calcaneus, exhibiting prominent squamous differentiation and displaying EWSR1 gene rearrangement.

Skeletal Radiol 2021 Jun 10. Epub 2021 Jun 10.

Sparsh Orthopedic Oncology, Ahmedabad, Gujrat, India.

Adamantinoma-like Ewing sarcoma is uncommonly reported in the skeletal sites, including small bones of the feet.A 15-year-old girl presented with pain and swelling in her left foot, leading to difficulty in walking for 8 months. Plain radiograph revealed an ill-defined, lytic-sclerotic lesion without significant periosteal reaction in her left calcaneus. Read More

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Giant Cell Tumor of Bone of the First Rib Successfully Treated with Combined Preoperative Denosumab Therapy and Surgery via a Transmanubrial Approach.

Am J Case Rep 2021 Jun 1;22:e931796. Epub 2021 Jun 1.

Department of Orthopedic Surgery, Kyushu Rosai Hospital, Kitakyushu, Fukuoka, Japan.

BACKGROUND Giant cell tumor of bone (GCTB) is a locally aggressive, intermediate tumor that rarely metastasizes. GCTB typically affects the ends of long bones and rarely involves the ribs. Curettage is typically the treatment of choice for GCTB in long bones. Read More

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Malignant giant cell tumor in the left upper arm soft tissue of an adolescent: A case report.

World J Clin Cases 2021 May;9(15):3704-3710

Department of Radiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan Province, China.

Background: Giant cell tumor of soft tissue (GCT-ST) is an extremely rare low-grade soft tissue tumor that is originates in superficial tissue and rarely spreads deeper. GCT-ST has unpredictable behavior. It is mainly benign, but may sometimes become aggressive and potentially increase in size within a short period of time. Read More

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FDG PET/CT in Tenosynovial Giant Cell Tumor of the Lumbar Facet Joint.

Clin Nucl Med 2021 May 26. Epub 2021 May 26.

From the Shanghai University, Shanghai Universal Medical Imaging Diagnostic Center School of Medicine, Shanghai University, Shanghai, China.

Abstract: Tenosynovial giant cell tumor rarely affects the facet joints of the spine. We describe FDG PET/CT findings in a case of tenosynovial giant cell tumor arising from the left L2 to L3 facet joint. The tumor caused osteolytic bone destruction of the facet joint and showed intense FDG uptake with SUVmax of 10. Read More

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Cyclin D1 expression in ganglioglioma, pleomorphic xanthoastrocytoma and pilocytic astrocytoma.

Exp Mol Pathol 2021 May 19;121:104652. Epub 2021 May 19.

University Hospital of Saint Etienne, North Hospital, Department of Pathology, Avenue Albert Raimond, 42055, Saint Etienne CEDEX 2, France; Corneal Graft Biology, Engineering and Imaging Laboratory, BiiGC, EA2521, Federative Institute of Research in Sciences and Health Engineering, Faculty of Medicine, Jean Monnet University, Saint-Etienne, France.

Ganglioglioma, pleomorphic xanthoastrocytoma (PXA) and pilocytic astrocytoma are rare brain neoplasms with frequent activation of mitogen-activated protein (MAP) kinase pathway. A downstream marker of MAP-kinase pathway activation is cyclin D1. However, the expression of cyclin D1 has not been studied in the differential diagnosis between these brain tumors. Read More

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Spinal Bony Involvement of IgG4-related Disease Treated by a Spondylectomy.

NMC Case Rep J 2021 Apr 2;8(1):27-31. Epub 2021 Apr 2.

Department of Neurosurgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

Immunoglobulin G4-related sclerosing disease (IgG4RD) is an emerging immune-mediated fibro-inflammatory disorder which can involve any organ. We describe the first IgG4-RD spondylitis treated with total en-bloc spondylectomy (TES). A 55-year-old man presented with back pain. Read More

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Tenosynovial giant cell tumor involving the cervical spine: A case report.

World J Clin Cases 2021 May;9(14):3394-3402

Department of Spine Surgery, Xiangya Hospital, Central South University, Changsha 410008, Hunan Province, China.

Background: Tenosynovial giant cell tumors (TGCTs) are a frequent benign proliferative disease originating from the synovial membrane. However, TGCTs rarely occur in the spine. The purpose of this paper is to report a case of TGCT occurring in the cervical spine. Read More

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H3F3A-mutated Giant Cell Tumour of Bone without Giant Cells - Clinical Presentation, Radiology, and Histology of Three Cases.

Histopathology 2021 May 15. Epub 2021 May 15.

Bone Tumour Reference Center at the Institute of Pathology, University Hospital Basel, Basel, Switzerland.

Aims: Giant cell tumour of bone (GCTB) is histologically defined as a lesion containing reactive giant cells and a neoplastic mononuclear cell population; in up to 92% GCTB is characterized by a specific mutation of the histone gene H3F3A. The cellular composition ranges from giant cell-rich to giant cell-poor tumours. The diagnosis of GCTB can be challenging and several other lesions need to be excluded, e. Read More

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A huge malignant phyllodes tumor of the breast with osteoclast-like giant cells: a case report.

Gland Surg 2021 Apr;10(4):1508-1514

Department of Breast Surgery, Second Affiliated Hospital of Dalian Medical University, Dalian, China.

The malignant phyllodes tumor (PT) of the breasts is a rare type of fibroepithelial neoplasm. Osteoclast-like giant cells (OLGCs) exist in many types of tumors. But malignant PTs with OLGCs were rarely reported. Read More

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A case report. Tenosynovial giant cell tumour in the tendon of extensor digitorium longus.

Foot (Edinb) 2021 Jun 23;47:101775. Epub 2021 Jan 23.

Wye Valley NHS Trust, Department of Podiatric Surgery, Belmont, Ruckland Lane, Hereford, United Kingdom. Electronic address:

Soft tissue lesions found within the foot and ankle can vary in their origin. Tenosynovial giant-cell tumours (TSGCT) are quoted as rare in their presentation yet also reported to be the sixth most common benign lesion in the foot. This article presents a case report following the patient journey suffering with a TSGCT of the fourth toe. Read More

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Hypopharyngeal spindle cell lipoma: A case report and review of literature.

Medicine (Baltimore) 2021 May;100(18):e25782

Department of Otorhinolaryngology.

Rationale: Spindle cell lipoma is a rare, uncommon type of benign lipomatous tumor, a distinct group of lipomas composed of mature adipocytes, uniform spindle cells, and multinucleated giant cells associated with ropey collagen. Immunohistochemically, spindle cell lipoma is characterized by the diffuse expression of CD34.

Patient Concerns: We present a rare case of a 56-year-old man who complained of vomiting out of a smooth and giant mass in the oral cavity provoked by an intra-abdominal pressure increase. Read More

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Sacral Giant Cell Tumor-Induced Cauda Equina Syndrome: Case Report with Successful Management.

J Neurosci Rural Pract 2021 Apr 4;12(2):398-401. Epub 2020 Nov 4.

Department of Pathology, All India Institute of Medical Sciences, Patna, Bihar, India.

Sacral giant cell tumor (GCT) is a rare entity. It often presents late after massive enlargement of tumor. Here we are reporting a case of sacral GCT treated successfully at our institute. Read More

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Angioleiomyoma of the sacrum: a case report and literature review of similar sacral lesions.

Radiol Case Rep 2021 Jun 10;16(6):1428-1432. Epub 2021 Apr 10.

Department of Oncology, Tai'an City Cancer Prevention Hospital, Taian City Shandong, China.

Angioleiomyoma is a solitary smooth muscle cell tumor that originates from the tunical media of arteries and veins. Its origin in the sacrum is rare, only one case has been recorded in the literature to date, but cases with bone destruction are even rarer. We present a 49-year-old woman with lumbosacral pain, unsteady gait and right lower extremity pain for two years, accompanied by radiation pain. Read More

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Chondroblastoma of the patella with secondary aneurysmal bone cyst, an easily misdiagnosed bone tumor:a case report with literature review.

BMC Musculoskelet Disord 2021 Apr 23;22(1):381. Epub 2021 Apr 23.

Ningxia Medical University, 1160 Shengli Street, Xingqing District, Yinchuan, 750004, People's Republic of China.

Background: Chondroblastoma (CB) is a rare, primary, benign bone tumor that commonly affects men aged 15-20 years. It is usually detected in the epiphysis of the long bones, such as the proximal femur, humerus, and tibia. The patella is an infrequent site. Read More

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Three-dimensional-printed custom-made patellar endoprosthesis for recurrent giant cell tumor of the patella: A case report and review of the literature.

World J Clin Cases 2021 Apr;9(11):2524-2532

Department of Orthopedics, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China.

Background: Giant cell tumor (GCT) is a benign lesion and rarely involves the patella. This disease is characterized by a relatively high recurrence rate after primary treatment. resection has been a predominant option for recurrent GCT. Read More

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Role of diffusion-weighted MRI in differentiating between benign and malignant bone lesions: a prospective study.

Clin Radiol 2021 Apr 14. Epub 2021 Apr 14.

Radio-diagnosis Department, Faculty of Medicine, South Valley University, Qena, Egypt.

Aim: To evaluate the ability of diffusion-weighted magnetic resonance imaging (DW-MRI) to differentiate between benign and malignant bony tumours.

Materials And Methods: This prospective study was conducted from October, 2018 to December, 2019. The study included 62 patients (37 male and 25 female) with clinically suspected bony lesions referred to the Radiology Department. Read More

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Acute leg compartment syndrome after CT-guided core needle biopsy of a giant cell tumor of the proximal fibula.

Acta Orthop Belg 2020 Dec;86(4):624-627

Imaging-guided percutaneous core needle biopsy (CNB) is the preferred diagnostic method for bone and soft tissue tumors. In less than 1% of cases, complications are clinically significant and include mainly haema-toma and bleeding. We present a case of acute compartment syndrome (ACS) following CNB of the proximal fibula. Read More

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December 2020

Prediction of the early recurrence in spinal giant cell tumor of bone using radiomics of preoperative CT: Long-term outcome of 62 consecutive patients.

J Bone Oncol 2021 Apr 16;27:100354. Epub 2021 Mar 16.

Department of Radiology, Peking University Third Hospital, 49 North Garden Road, Haidian District, Beijing 100191, China.

Objectives: To determine if radiomics analysis based on preoperative computed tomography (CT) can predict early postoperative recurrence of giant cell tumor of bone (GCTB) in the spine.

Methods: In a retrospective review, 62 patients with pathologically confirmed spinal GCTB from March 2008 to February 2018, with a minimum follow-up of 24 months, were identified. The mean follow-up was 73. Read More

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Osteosarcoma Mimicking Tenosynovial Giant Cell Tumor of the Hip in a Pediatric Patient: A Case Report.

JBJS Case Connect 2021 04 13;11(2). Epub 2021 Apr 13.

University of Pennsylvania, Philadelphia, Pennsylvania.

Case: A 17-year-old boy presented to the clinic complaining of right hip pain after soccer participation. Clinical findings and imaging studies led to the diagnoses of femoroacetabular impingement and diffuse tenosynovial giant cell tumor (TGCT). Comprehensive arthroscopic management and biopsy revealed a diagnosis of osteosarcoma. Read More

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Radiological Assessment of Giant Cell Tumour of Bone in the Sacrum: From Diagnosis to Treatment Response Evaluation.

Curr Med Imaging 2021 Apr 6. Epub 2021 Apr 6.

Department of Orthopaedic Surgery, IRCCS Rizzoli, Bologna. Italy.

Giant cell tumour of bone (GCTB) typically occurs in young adults from 20-40 years old. Although the majority of lesions are located in the epi-metaphyses of the long bones, approximately one third of tumours is located in the axial skeleton, of which only 4% in the sacrum. Sacral tumours tend to be large at the time of presentation, and they present with aggressive features such as marked cortical destruction and an associated soft tissue component. Read More

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A Giant Borderline Phyllodes Tumor of Breast With Skin Ulceration Leading to Non-Insular Tumorigenic Hypoglycemia: A Case Report and Literature Review.

Front Endocrinol (Lausanne) 2021 25;12:651568. Epub 2021 Mar 25.

Department of Pathology, The Fourth Affiliated Hospital of Harbin Medical University, Harbin, China.

Phyllodes tumor (PT) is a special type of breast tumors, including three types: malignant, borderline, and benign. Most of these tumors form unilateral disease and can rapidly increase in size. The occurrence of axillary lymph node metastasis is rare. Read More

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A severe headache due to pigmented villonodular synovitis in a rare location: facial nerve on temporomandibular joint. A case report.

Cranio 2021 Apr 9:1-4. Epub 2021 Apr 9.

Pathology Department, Haydarpa#x15F;a Numune Training and Research Hospital, Istanbul, Turkey.

: Pigmented villonodular synovitis (PVNS) is an infrequent benign tumor-like proliferative lesion developing from the synovial membranes of the joint, tendon sheath, and bursa.: A 44-year-old woman with numbness on the right side of her face, severe headaches, and swelling in temporomandibular region is presented. On head and neck magnetic resonance imaging, an encapsulated mass approximately 2 cm was detected. Read More

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Bilateral Renal Angiomyolipomas and Subependymal Giant Cell Astrocytoma Associated with Tuberous Sclerosis Complex: a Case Report and Review of The Literature.

Balkan J Med Genet 2020 Nov 23;23(2):93-98. Epub 2021 Mar 23.

University Clinic of Nephrology, Skopje, Republic of North Macedonia.

Tuberous sclerosis complex (TSC) is an autosomal-dominant multi system disorder. The genetic basis of the disorder is mutations in the or gene, which leads to over activation of the mammalian target of rapamycin (mTOR) protein complex and results in development of benign tumors in different body systems such as brain, skin, lungs and kidney. The mTOR inhibitors are presently the main treatment option for patients with TSC. Read More

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November 2020

Benign Osseous Tumors and Tumor-Like Conditions.

Semin Ultrasound CT MR 2021 Apr 29;42(2):150-163. Epub 2020 Aug 29.

Department of Musculoskeletal Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX.

We will provide an imaging-focused discussion of 3 benign bone tumors that do not fit in the categories of cartilaginous tumors or osteoid tumors. We have chosen giant cell tumor of bone, unicameral bone cyst, and fibrous dysplasia. All 3 of these entities are common enough that one does not have to be a musculoskeletal radiologist in a cancer hospital to encounter them occasionally, but none of them should be seen frequently. Read More

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Anti-IL17 antibody Secukinumab therapy is associated with ossification in giant cell tumor of bone: a case report of pathologic similarities and therapeutic potential similar to Denosumab.

BMC Musculoskelet Disord 2021 Apr 1;22(1):320. Epub 2021 Apr 1.

Department of Surgery, Orthopaedic Service, Memorial Sloan Kettering Cancer Center, 1275 York Ave., New York, NY, 10065, USA.

Background: Giant cell tumor of bone is a benign, locally aggressive neoplasm. Surgical resection is the preferred treatment method. However, for cases in which resection poses an increased risk to the patient, denosumab (anti-RANKL monoclonal antibody) is considered. Read More

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Bone Tumours of the Talus: 18-Year Cohort of Patients With Rare Osteoid Lesions.

Cureus 2021 Feb 26;13(2):e13565. Epub 2021 Feb 26.

Medical Sciences, Keele University, Keele, GBR.

Background Bone tumours of the talus are a rare cause of ankle pain. This study aims to provide additional clinical clarity regarding the presentation and management of a minimally researched topic. Methods Sixteen patients were diagnosed with bone tumour of the talus between 2002 and 2020 following referral for ankle pain. Read More

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February 2021

Statistics of pathogenic bacteria in the search of host cells.

Nat Commun 2021 03 31;12(1):1990. Epub 2021 Mar 31.

Université Côte d'Azur, Laboratoire J.A. Dieudonné, UMR 7351 CNRS, Nice, France.

A crucial phase in the infection process, which remains poorly understood, is the localization of suitable host cells by bacteria. It is often assumed that chemotaxis plays a key role during this phase. Here, we report a quantitative study on how Salmonella Typhimurium search for T84 human colonic epithelial cells. Read More

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[Ⅱ. Success and Limitations of Denosumab for Giant Cell Tumor of Bone].

Naofumi Asano

Gan To Kagaku Ryoho 2021 Mar;48(3):346-350

Dept. of Orthopaedic Surgery, Keio University School of Medicine.

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Cytomorphological Evaluation of Synovial Lesions in a Tertiary Care Centre in North India: A Retrospective Study.

J Cytol 2020 Oct-Dec;37(4):166-169. Epub 2020 Nov 6.

Department of Radio-Diagnosis and Imaging, Government Medical College, Jammu (J&K), India.

Background: Numerous pathological processes involve synovium and periarticular tissues that are characteristic and in some cases specific to a particular disease. Synovial fluid is a thick, stringy fluid found in the cavity of synovial joint. Examination of the synovium plays a key role in the diagnosis of many joint diseases. Read More

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November 2020