3,506 results match your criteria Giant Cell Tumor Imaging


Multimodality Imaging Features of a Misleading Sacral Giant Cell Tumor in 18F-FDG PET/CT, Bone Scan, and MRI.

Clin Nucl Med 2020 Jun 25. Epub 2020 Jun 25.

From the Unité de Médecine Nucléaire.

We report the case of an asymptomatic 66-year-old woman referred for initial staging of an invasive ductal breast carcinoma. Initial workup incidentally revealed a bone tumor of right sacral wing corresponding to a giant cell tumor (GCT). We present the imaging characteristics of GCT on Tc-HDP bone scan (doughnut sign), F-FDG PET/CT (intense and heterogeneous uptake of a prominent geographic lytic lesion with partial rupture of cortical), and MRI (hyposignal with gadolinium enhancement on T1-weighted images and heterogeneous hypersignal on T2-weighted images). Read More

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http://dx.doi.org/10.1097/RLU.0000000000003148DOI Listing

Bone up on spinal osseous lesions: a case review series.

Insights Imaging 2020 Jun 29;11(1):80. Epub 2020 Jun 29.

Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL, 32224, USA.

Spinal osseous neoplasms are frequently encountered and can be challenging when present as solitary lesions. Familiarity with the range of benign and malignant spinal pathology can help the radiologist formulate a comprehensive differential diagnosis. This article focuses on the spectrum of extradural spinal tumors, accounting for the majority of primary spinal tumors, by comparing the epidemiology, pathophysiology, clinical presentation, and characteristic imaging appearance of these lesions. Read More

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http://dx.doi.org/10.1186/s13244-020-00883-6DOI Listing

Bone Tumors: Benign Bone Tumors.

Authors:
Yee Lam

FP Essent 2020 Jun;493:11-21

UNC Department of Family Medicine, 590 Manning Drive, Chapel Hill, NC 27599.

Primary benign bone tumors are uncommon and most often affect children and young adults. They typically are detected incidentally on imaging, though some patients present with pain, swelling, or other symptoms. The four main categories of benign bone tumor are: bone-forming (eg, osteoid osteoma, osteoblastoma, fibrous dysplasia, enostosis), cartilage-forming (eg, osteochondroma, enchondroma), connective tissue, and vascular; the latter two are rare. Read More

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When primary hyperparathyroidism comes as good news.

Endocrinol Diabetes Metab Case Rep 2020 Jun 4;2020. Epub 2020 Jun 4.

Department of Medicine and Surgery, Endocrine Unit, University of Insubria, Varese, Italy.

Summary: Brown tumors are osteoclastic, benign lesions characterized by fibrotic stroma, intense vascularization and multinucleated giant cells. They are the terminal expression of the bone remodelling process occurring in advanced hyperparathyroidism. Nowadays, due to earlier diagnosis, primary hyperparathyroidism keeps few of the classical manifestations and brown tumors are definitely unexpected. Read More

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http://dx.doi.org/10.1530/EDM-20-0046DOI Listing

A Case Report of Giant Cell Tumor of the Flexor Tendon Sheath in Index Finger.

J Orthop Case Rep 2020 ;9(6):78-81

Department of Orthopedics, Jawaharlal Nehru Medical College, Datta Meghe Institute of Medical Sciences (Deemed to be University), Sawangi, Wardha, Maharashtra, India.

Introduction: Giant cell tumor of the tendon sheath (GCTTS) is an uncommon benign soft tissue tumor of unknown etiology. It is seen more commonly in hand than ankle and foot. It presents as a painless and palpable swelling. Read More

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http://dx.doi.org/10.13107/jocr.2019.v09.i06.1598DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7276606PMC
January 2020

Giant Cell Tumor of Third Metacarpal: A Rare Case Report and Review of Literature.

J Orthop Case Rep 2020 ;9(6):11-14

Department of Orthopaedics, Apollo Hospital, Bhubaneswar, Odisha, India.

Introduction: Giant cell tumor (GCT) or osteoclastoma is an osteolytic, mostly benign but locally aggressive tumor occurring in young adults at the meta-epiphyseal region of long bones such as lower end of the femur, upper end of the tibia, and lower end of the radius, and proximal humerus in descending order of frequency. Only 2% of all GCT of bone occur in hand. GCT of metacarpal (MC) has different characteristics than that of other long bones. Read More

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http://dx.doi.org/10.13107/jocr.2019.v09.i06.1566DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7276591PMC
January 2020

Update on Circumscribed Gliomas and Glioneuronal Tumors.

Surg Pathol Clin 2020 Jun;13(2):249-266

Department of Pathology and Immunology, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA. Electronic address:

Well-circumscribed intra-axial CNS tumors encompass a wide variety of gliomas and glioneuronal tumors, usually corresponding to WHO grades I and II. Nonetheless, sometimes high-grade 'diffuse' gliomas such as gliosarcoma and giant cell glioblastoma can be relatively circumscribed but are often found to have foci of diffuse infiltration on careful examination, harboring distinct molecular alterations. These tumors are excluded from the discussion in this chapter with the current review emphasizing on lower-grade entities to include a brief description of their histology and associated molecular findings. Read More

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http://dx.doi.org/10.1016/j.path.2020.02.004DOI Listing

Functional outcome in giant cell tumor of distal radius treated with excision and fibular arthroplasty: a case series.

Eur J Orthop Surg Traumatol 2020 May 1. Epub 2020 May 1.

Department of Orthopaedics, All India Institute of Medical Sciences, Rishikesh, 318, Building 86, Rishikesh, Uttarakhand, 249203, India.

Introduction: Giant cell tumor (GCT) of bone is a locally aggressive benign neoplasm that is associated with a wide spectrum of biological activity ranging from latent benign to highly recurrent and has occasional metastatic potential. It affects the meta-epiphyseal region of long bones of young adults with most common site involved is the distal femur, followed by the distal radius. Plain radiographs and contrast-enhanced magnetic resonance imaging are the imaging modalities widely used followed by definite histopathology for diagnosis. Read More

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http://dx.doi.org/10.1007/s00590-020-02679-2DOI Listing

Giant cell tumor of the talus: A case report.

Radiol Case Rep 2020 Jul 22;15(7):825-831. Epub 2020 Apr 22.

Department of Radiology, Texas Tech University Health Sciences Center El Paso, 5001 El Paso Drive, CSB-A02, El Paso, TX 79905.

Giant cell tumor is a benign primary bone neoplasm which most often occurs in a periarticular location. Involvement of the bones of the foot and ankle is rare, and there have been a limited number of previous case reports involving the talus. Here we report a case of giant cell tumor of the talus, which was initially radiographically occult in a 43-year-old female, with emphasis on MRI imaging characteristics. Read More

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http://dx.doi.org/10.1016/j.radcr.2020.03.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7182696PMC

Radiological findings of denosumab treatment for giant cell tumours of bone.

Skeletal Radiol 2020 Apr 26. Epub 2020 Apr 26.

Radiology Department, Nuffield Orthopaedic Centre, Oxford, OX3 7HE, UK.

Giant cell tumours of bone (GCTB) are benign giant cell-rich tumours typically occurring in the epi-metaphysis of skeletally mature patients. Despite their benign classification, GCTB may be locally aggressive with local recurrence as a challenging issue. Denosumab is a human monoclonal antibody that inhibits osteolysis via the RANK-RANK ligand pathway. Read More

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http://dx.doi.org/10.1007/s00256-020-03449-1DOI Listing

Recurrence of pigmented villonodular synovitis of the knee: A case report with review of literature on the risk factors causing recurrence.

Medicine (Baltimore) 2020 Apr;99(16):e19856

Department of Orthopaedic Surgery, Wuhan Fourth Hospital, Wuhan City, China.

Rationale: Pigmented villonodular synovitis is a rare disease which may involve any joints. It has localized and diffuse forms, and the latter is more aggressive with a higher recurrence rate. Different treatments are applied to each form of the disease, but there is no standard surgical procedure or any consensus on whether adjuvant therapy should be used. Read More

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http://dx.doi.org/10.1097/MD.0000000000019856DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7220429PMC

Femoral pseudotumor secondary to injury in a patient with idiopathic thrombocytopenic purpura: Case report.

Medicine (Baltimore) 2020 Apr;99(15):e19788

Department of Radiology, The Third Hospital of Hebei Medical University, Shijiazhuang Hebei Province, China.

Rationale: Idiopathic thrombocytopenic purpura (ITP) is the condition of having a low platelet count of unknown causes and is a poorly understood acquired hemorrhagic disease involving destruction of platelets in the reticuloendothelial system induced by antiplatelet antibodies. Patients with ITP can have traumatic intra-articular, intraosseous or soft tissue hemorrhage which may present as a rare intraosseous pseudotumor on medical imaging.

Patient Concerns: A 30-year old male patient had complaint of pain in the right leg for 1 year. Read More

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http://dx.doi.org/10.1097/MD.0000000000019788DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7220076PMC
April 2020
5.723 Impact Factor

Shoulder Tumor/Tumor-Like Lesions: What to Look for.

Magn Reson Imaging Clin N Am 2020 May;28(2):301-316

Department of Radiology, University of California San Diego, School of Medicine, UCSD Teleradiology and Education Center, 408 Dickinson Street, Mail Code #8226, San Diego, CA 92103-8226, USA.

This article discusses the most common tumor and tumor-like lesions arising at the shoulder. Osseous tumors of the shoulder rank second in incidence to those at the knee joint and include benign osteochondromas and myeloma or primary malignant lesions, such as osteosarcoma or chondrosarcomas. Soft tissue tumors are overwhelmingly benign, with lipomas predominating, although malignant lesions, such as liposarcomas, can occur. Read More

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http://dx.doi.org/10.1016/j.mric.2019.12.011DOI Listing

Intraosseous gout mimicking giant cell tumor of the patella.

Skeletal Radiol 2020 Aug 31;49(8):1325-1328. Epub 2020 Mar 31.

Department of Radiology, John D. Dingell VA Medical Center, 4646 John R St., Detroit, MI, 48201, USA.

Intraosseous gout involving the patella is an unusual presentation of the common inflammatory crystal deposition disease. In most reported cases of gout in the patella, there is prominent involvement of the adjacent patellar or quadriceps tendons of the extensor mechanism. A report from Japan describes another pattern of deposition, with a lesion arising in the synchondrosis of a bipartite patella. Read More

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http://dx.doi.org/10.1007/s00256-020-03422-yDOI Listing

Huge aneurysmal bone cyst secondary to giant cell tumor of the hand phalanx: a case report and related literature.

BMC Cancer 2020 Mar 19;20(1):233. Epub 2020 Mar 19.

Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Background: Aneurysmal bone cyst (ABC) secondary to Giant Cell Tumor of bone (GCT) is a rare lesion, of which the incidence is about 0.011 to 0.053 per 100,000 every year. Read More

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http://dx.doi.org/10.1186/s12885-020-06746-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7083031PMC

Do Massive Allograft Reconstructions for Tumors of the Femur and Tibia Survive 10 or More Years after Implantation?

Clin Orthop Relat Res 2020 Mar;478(3):517-524

L. A. Aponte-Tinao, M. A. Ayerza, J. I. Albergo, G. L. Farfalli, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina.

Background: Massive bone allografts have been used for limb salvage in patients undergoing bone tumor resections as an alternative to endoprostheses. Although several studies on massive allograft reconstructions for bone tumors reported that most complications occur in the first 3 years after surgery, there are no long-term reports on complications to substantiate this contention. We believe such information is important so that surgeons and patients can make more informed decisions when choosing a reconstructive method after tumor resection. Read More

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http://dx.doi.org/10.1097/CORR.0000000000000806DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7145084PMC

A rare localized giant cell tumor of the tendon sheath originating from the ligamentum mucosum: A case report.

Jt Dis Relat Surg 2020 ;31(1):149-53

Department of Orthopedics and Traumatology, Düzce University Faculty of Medicine, Düzce, Turkey.

Giant cell tumor of the tendon sheath (GCTTS) occurs most often in the hand and rarely in the feet, and as an extremely uncommon presentation in the knee joint. Case reports involving GCTTS in the knee joint generally describe it originating from the nearby anterior cruciate ligament, posterior cruciate ligament, patellar tendon, and medial plica. To the best of our knowledge, there are no previously reported case reports involving GCTTS originating in the ligamentum mucosum. Read More

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http://dx.doi.org/10.5606/ehc.2020.72323DOI Listing
January 2020

Benign bone tumors of hand and wrist: evaluation of diagnosis and treatment.

Jt Dis Relat Surg 2020 ;31(1):81-7

Department of Orthopedics and Traumatology, Health Sciences University, Haydarpaşa Numune Training and Research Hospital, Istanbul, Turkey.

Objectives: This study aims to investigate the choice of graft or cement, the relationship between the graft types and union rates, functional results, and complications in hand and wrist benign bone lesions while also evaluating the diagnosis and treatment modalities of lesions with high recurrence potential like giant cell- containing lesions.

Patients And Methods: Between September 2005 and May 2016, 48 benign osseous hand and wrist tumors of 48 patients (22 males, 26 females; mean age 33±13.1 years; range, 11 to 70 years) were reviewed retrospectively. Read More

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http://dx.doi.org/10.5606/ehc.2020.72162DOI Listing
January 2020

Fetal subependymal giant cell astrocytoma: A case report and review of the literature.

Surg Neurol Int 2020 25;11:26. Epub 2020 Feb 25.

Departments of Neurosurgery, Children's Hospital "Aghia Sofia", Athens, Greece.

Background: Subependymal giant cell astrocytomas (SEGAs) appear approximately in 10% of patients with tuberous sclerosis. These tumors are most commonly diagnosed in childhood and adolescence, with diagnosed SEGAs being an extremely rare entity.

Case Description: We present the case of a congenital SEGA detected in an antenatal ultrasound and further investigated with fetal magnetic resonance imaging (MRI) scans at 22 and 32 weeks of gestational age. Read More

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http://dx.doi.org/10.25259/SNI_10_2019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7049878PMC
February 2020

Giant cell tumor of bone following denosumab treatment: assessment of tumor response using various imaging modalities.

Insights Imaging 2020 Feb 27;11(1):41. Epub 2020 Feb 27.

Medical Imaging Department, King Faisal Specialist Hospital and Research Centre, Riyadh, Kingdom of Saudi Arabia.

Background: Giant cell tumor (GCT) is a nonmalignant neoplasm composed of multinucleated giant and mononuclear stromal cells. This study aimed to compare imaging findings of GCT pre- and post-denosumab treatment, including lesion size, percentage of signal intensity/density change, and time of initial objective tumor response. This will have a great impact on selection of most appropriate imaging technique to accurately measure therapy response and its related complications, which would influence the physicians to tailor the treatment regimen to suit each patient. Read More

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http://dx.doi.org/10.1186/s13244-020-00845-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7046877PMC
February 2020

Diagnostic challenges in a case of an isolated third nerve palsy.

Am J Ophthalmol Case Rep 2020 Jun 30;18:100585. Epub 2020 Jan 30.

Ophthalmology, Standard University, USA.

Purpose: Neuro-ophthalmic manifestations may be the first and sole presenting feature of a nasopharyngeal carcinoma. Peri-neural spread is an emerging phenomenon that explains the distant spread of tumour cells well beyond the local extent of invasion. This under recognized route of tumour spread often results in delayed diagnosis and reduced life expectancy. Read More

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http://dx.doi.org/10.1016/j.ajoc.2020.100585DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7031130PMC

Tenosynovial giant cell tumor of the cervical spine: a case report.

Spinal Cord Ser Cases 2019 02 25;5(1):23. Epub 2019 Feb 25.

Department of Orthopaedic Surgery, School of Medicine, Keio University, Tokyo, Japan.

Introduction: Tenosynovial giant cell tumors (TSGCTs) generally occur in the limb joints, and only rarely in the spine. This case report describes a patient with TSGCT of the spine at C1-C2, which was treated surgically and diagnosed as TSGCT.

Case Presentation: A 32-year-old woman with a 4-month history of neck pain and numbness in both upper extremities was referred to our department. Read More

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http://dx.doi.org/10.1038/s41394-019-0172-1DOI Listing
February 2019

Soft-Tissue Tumors of the Hand-Imaging Features.

Can Assoc Radiol J 2020 May 22;71(2):161-173. Epub 2020 Jan 22.

Department of Radiology, University of Chicago, Chicago, IL, USA.

Imaging studies of the hands and fingers are common, and radiologists are generally comfortable with traumatic and degenerative conditions which arise frequently in daily practice. However, a variety of common and uncommon soft-tissue tumors also occur in the hand, the appropriate diagnosis of which can be a source of confusion for both clinicians and radiologists. These lesions often have overlapping imaging characteristics; however, a structured approach can help provide a focused differential diagnosis and impact further workup and management. Read More

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http://dx.doi.org/10.1177/0846537119888356DOI Listing

Recurrent giant cell tumour of the thoracic spine managed by total en bloc spondylectomy and denosumab therapy: a case report.

BMC Musculoskelet Disord 2020 Feb 15;21(1):105. Epub 2020 Feb 15.

Department of Orthopaedic Surgery, The First Affiliated Hospital of Nanchang University, Nanchang, 330006, Jiangxi, People's Republic of China.

Background: Giant cell tumour (GCT) of the bone is a rare, invasive benign bone tumour, which typically originates in the metaphyseal ends of long bones and rarely in the spine. Here, we report a rare case of recurrent GCT of the thoracic vertebra, which was managed by three-level total en bloc spondylectomy (TES) after denosumab therapy.

Case Presentation: A 50-year-old woman presented with a 2-month history of progressive lower back pain. Read More

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http://dx.doi.org/10.1186/s12891-020-3129-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7023717PMC
February 2020

Imaging of skull vault tumors in adults.

Insights Imaging 2020 Feb 13;11(1):23. Epub 2020 Feb 13.

Department of Neuroradiology, Hospital Universitari de Bellvitge, C. Feixa Llarga SN, 08907, L'Hospitalet de Llobregat, Spain.

The skull vault, formed by the flat bones of the skull, has a limited spectrum of disease that lies between the fields of neuro- and musculoskeletal radiology. Its unique abnormalities, as well as other ubiquitous ones, present particular features in this location. Moreover, some benign entities in this region may mimic malignancy if analyzed using classical bone-tumor criteria, and proper patient management requires being familiar with these presentations. Read More

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http://dx.doi.org/10.1186/s13244-019-0820-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7018895PMC
February 2020

Secondary aneurysmal bone cysts and associated primary lesions: imaging features of 49 cases.

Clin Imaging 2020 Jun 30;62:23-32. Epub 2020 Jan 30.

Department of Radiology and Biomedical Imaging, University of California, San Francisco, 505 Parnassus Ave, San Francisco, CA 94143, United States of America.

Purpose: To describe the imaging, anatomic, and clinical features of a series of secondary aneurysmal bone cysts (ABC) and to ascertain their most commonly associated primary bone lesions.

Methods: Forty-nine cases of histopathologically proven secondary ABCs were retrospectively reviewed. Demographic data and clinical history were obtained. Read More

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http://dx.doi.org/10.1016/j.clinimag.2020.01.022DOI Listing

[Clinicopathologic and molecular characteristics of myxoid angiomatoid fibrous histiocytoma].

Zhonghua Zhong Liu Za Zhi 2020 Jan;42(1):37-43

Department of Pathology, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical School, Hangzhou 310014, China.

To investigate the molecular genetic and clinicopathologic characteristics, immunophenotypes, diagnostic and differential diagnostic features of myxoid angiomatoid fibrous histiocytoma (MAFH). Three cases of MAFH were collected from the archives of Zhejiang Provincial People's Hospital between January 2015 to August 2018. The clinical and radiologic features, histomorphology, immunohistochemistry, molecular genetics and prognosis were analyzed. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0253-3766.2020.01.005DOI Listing
January 2020

[Molecular pathology in the diagnosis of bone tumors: current concepts].

Pathologe 2020 Mar;41(2):106-115

Knochentumor-Referenzzentrum, Institut für Pathologie, Universitätsspital Basel, Universität Basel, Schönbeinstrasse 40, Basel, 4031, Schweiz.

The integrative evaluation of histology and corresponding imaging is essential for the classification of bone tumors. Until a few years ago, there were hardly any molecular markers that could be used for diagnostic purposes. However, exome- and genome-wide sequencing analyses have since uncovered a number of tumor-specific aberrations that can be very helpful in ambiguous cases. Read More

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http://dx.doi.org/10.1007/s00292-019-00746-yDOI Listing

Cervical-Thoracic Epidural Giant Cell Reparative Granuloma: Case Report and Review of the Literature.

World Neurosurg 2020 Apr 10;136:66-69. Epub 2020 Jan 10.

Department of Medical Imaging, The Second Hospital of Hebei Medical University, Shijiazhuang, China. Electronic address:

Background: Giant cell reparative granuloma (GCRG) is a rare benign tumor. The jawbone is the most common site of occurrence, followed by sphenoid bone, craniofacial bone, hand and foot bones. The etiology of GCRG is unknown but may be related to an intraosseous hemorrhage following trauma. Read More

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http://dx.doi.org/10.1016/j.wneu.2020.01.015DOI Listing

A rare tumor in a rare location: giant cell tumor of the sacrum and ilium - case report and current perspectives.

Rom J Morphol Embryol 2019 ;60(3):985-992

Department of Oral Rehabilitation, Faculty of Dental Medicine, "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania;

Giant cell tumor (GCT) is considered a locally aggressive, intermediate grade benign bone neoplasm. In rare cases, GCT undergoes malignant degeneration or may cause distant metastasis, mainly in the pulmonary area. Most bone GCTs are situated in the epiphysis or metaphysis of long bones, while GCTs of the pelvis are quite rare. Read More

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Primary Pineal Rhabdomyosarcoma: A Rare Case.

Asian J Neurosurg 2019 Oct-Dec;14(4):1291-1294. Epub 2019 Nov 25.

Department of Pathology, Seth G.S.M.C, Mumbai, Maharashtra, India.

Primary pineal rhabdomyosarcoma (RMS) is extremely rare, and only three cases have been reported so far. Here, we report a case of 12-year-old male who presented with complaints of diplopia and diminution of vision since 15 days. He also had left-sided facial paresis. Read More

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http://dx.doi.org/10.4103/ajns.AJNS_53_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6896613PMC
November 2019

Giant Cervicodorsal Schwannoma.

J Exp Ther Oncol 2019 Dec;13(2):155-158

Department of Neurosurgery, Sri Ramachandra University, Chennai, Tamil Nadu, India.

Objective: Schwannomas are benign slow growing tumors that arise from myelin producing Schwann cells. Schwannomas developing in cervical-dorsal region are rare benign neoplasms which are emerges leisurely remains asymptomatic some times and functionally inactive tumours. Giant Schwannomas extending over two or more vertebral levels have been documented and attempts have been made to classify these in available literature, however inadequate. Read More

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December 2019

Surgical strategies for primary malignant tumors of the thoracic and lumbar spine.

Orthop Traumatol Surg Res 2020 02 13;106(1S):S53-S62. Epub 2019 Dec 13.

Université Paris Sud, hôpital Bicêtre, 78, rue du Général-Leclerc, 94275 Le Kremlin-Bicêtre cedex, France.

Background: Primary malignant tumors of the thoracic and lumbar spine are rare. They are mainly hematologic malignancies and more rarely sarcomas or chordomas. Giant-cell tumors and osteoblastomas, while benign, are locally very aggressive and their excision should be discussed as an option. Read More

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http://dx.doi.org/10.1016/j.otsr.2019.05.028DOI Listing
February 2020

Primary Intra-Osseous Basaloid Squamous Cell Carcinoma of Mandible: Report of Rare Case with Proposed Diagnostic Criteria.

J Coll Physicians Surg Pak 2019 Dec;29(12):1215-1217

Department of Oral Pathology, NIMS Dental College, Jaipur, India.

Basaloid squamous cell carcinoma (BSCC) is a distinctive variant of squamous cell carcinoma (SCC) characterised by nests of basaloid cells. BSCC is an aggressive and rare tumor of head and neck region; and is relatively rare in oral cavity in comparison to SCC. Although, infrequent, but primary intra-osseous SCC (PIOSCC) has been reported in the jaws. Read More

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http://dx.doi.org/10.29271/jcpsp.2019.12.1215DOI Listing
December 2019
0.318 Impact Factor

Development of Fluorescently Labeled SSEA-3, SSEA-4, and Globo-H Glycosphingolipids for Elucidating Molecular Interactions in the Cell Membrane.

Int J Mol Sci 2019 Dec 7;20(24). Epub 2019 Dec 7.

The United Graduate School of Agricultural Science, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan.

Glycosphingolipids (GSLs), such as the globo-series GSLs stage-specific embryonic antigen 3 (SSEA-3), SSEA-4, and Globo-H, are specifically expressed on pluripotent stem cells and cancer cells, and are known to be associated with various biological processes such as cell recognition, cell adhesion, and signal transduction. However, the behavior and biological roles of these GSLs are still unclear. In our previous study, we observed the interactions between the lipid raft and GSLs in real-time using single-molecule imaging, where we successfully synthesized various fluorescent analogs of GSLs (e. Read More

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http://dx.doi.org/10.3390/ijms20246187DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6941013PMC
December 2019

Fluorescein-guided removal of peripheral nerve sheath tumors: a preliminary analysis of 20 cases.

J Neurosurg 2019 Dec 6:1-10. Epub 2019 Dec 6.

1Department of Neurosurgery, Fondazione IRCCS Istituto Neurologico Carlo Besta.

Objective: Benign peripheral nerve sheath tumors (PNSTs) include mainly schwannomas-the most common tumors arising from peripheral nerves-and neurofibromas. Due to their origin, distinguishing between functional intact nerve and the fibers from whence the PNST arose may not always be easy to perform. The introduction of intraoperative tools to better visualize these tumors could be helpful in achieving a gross-total resection. Read More

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http://dx.doi.org/10.3171/2019.9.JNS19970DOI Listing
December 2019

Sonic Hedgehog-Activated Large Cell/Anaplastic Medulloblastoma with Myogenic Differentiation.

World Neurosurg 2020 Mar 3;135:16-18. Epub 2019 Dec 3.

Departments of Neuropathology and Neurosurgery, National Institute of Mental Health and Neurosciences, Bangladore, India. Electronic address:

Background: Medulloblastoma (MB) with myogenic differentiation is a rare histologic variant.

Case Description: We report a case of a 7-year-old female child who presented with a left cerebellar mass. Histopathologic examination showed a cellular neoplasm comprising undifferentiated cells along with foci of bizarre giant cells. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.11.161DOI Listing

Giant cell tumor of soft tissue of the breast: Case report with H3F3A mutation analysis and review of the literature.

Pathol Res Pract 2020 Feb 19;216(2):152750. Epub 2019 Nov 19.

Division of Pathology, Cancer Institute of Japanese Foundation for Cancer Research, Tokyo, Japan.

Giant cell tumors of soft tissue (GCT-ST) arising in the breast are extremely rare. We report a unique case of breast GCT-ST coincident with ductal carcinoma in situ (DCIS), diagnosed with histological, immunohistochemical, and H3F3A (Histone H3.3) mutation analyses. Read More

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http://dx.doi.org/10.1016/j.prp.2019.152750DOI Listing
February 2020
4 Reads

Giant Cell Tumor with Secondary Aneurysmal Bone Cyst of the Patella: A Case Report.

Cureus 2019 Oct 1;11(10):e5819. Epub 2019 Oct 1.

Pathology, All India Institute of Medical Sciences, Bhubaneswar, IND.

A 15-year-old girl presented with pain and swelling on the anterior aspect of the right knee for one year. The radiological evaluation with x-rays and magnetic resonance imaging suggested a benign aggressive lesion of the right patella with a cortical breach. Core needle biopsy of the lesion revealed it to be a giant cell tumor (GCT). Read More

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http://dx.doi.org/10.7759/cureus.5819DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6827857PMC
October 2019

[Unique Experience of Cherubism Targeted Therapy].

Probl Sotsialnoi Gig Zdravookhranenniiai Istor Med 2019 Aug;27(Special Issue):608-622

Russian Children's Clinical Hospital of Pirogov Russian National Research Medical University, 119571, Moscow, Russia.

The family form of giant cell reparative granuloma or cherubism is a rare benign lesion of the jaws which causes face deformation reminiscent of the cherubs portrayed in Renaissance art. Radical surgery, especially in children before puberty, is impossible or irrational, because it leads to disablement. For four years, a child with cherubism was undergoing an outpatient supervision in the Department of Maxillofacial Surgery in Russian Children Clinical Hospital. Read More

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http://dx.doi.org/10.32687/0869-866X-2019-27-si1-608-622DOI Listing

Lipoma arborescens - Uncommon Diagnosis for Joint Swelling: Case Report and Review of the Literature.

Z Orthop Unfall 2019 Nov 19. Epub 2019 Nov 19.

Gelenkchirurgie, HELIOS ENDO-Klinik Hamburg.

Introduction: Soft tissue swelling of the knee joint can be caused by many diseases. Lipomas are one of the most reasonable differential diagnoses we have to consider. Therefore, we now present the uncommon case of a Lipoma arborescens (LA) and differentiate it from a quite similar manifesting spindle cell lipoma as follows. Read More

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http://dx.doi.org/10.1055/a-0997-6959DOI Listing
November 2019

[A Case Of cT3bN2M0 Pleomorphic Giant Cell Carcinoma of the Bladder without Recurrence after Neoadjuvant Chemotherapy and Radical Cystectomy for 4 Years].

Hinyokika Kiyo 2019 Sep;65(9):377-380

The Department of Urology, Shimada Municipal Hospital.

Pleomorphic giant cell carcinoma of the bladder is a highly malignant subtype and its prognosis is very poor. Among 22 previously reported cases, 14 cases were diagnosed as muscle-invasive tumors and the 10 patients died within 1.5 years after the initial diagnosis. Read More

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http://dx.doi.org/10.14989/ActaUrolJap_65_9_377DOI Listing
September 2019

Giant cell tumor of tendon sheath in the wrist that damaged the extensor indicis proprius tendon: a case report and literature review.

BMC Cancer 2019 Nov 6;19(1):1057. Epub 2019 Nov 6.

Department of Orthopedics, The First Affiliated Hospital, Zhejiang University, #79 Qingchun Road, Hangzhou, Zhejiang Province, 310003, People's Republic of China.

Background: Giant cell tumor of the tendon sheath (GCTTS) is a benign soft tissue (synovial membrane) tumor that rarely involves the hands or wrists. And Tendon impairment caused by GCTTS is extremely rare.

Case Presentation: Here, we reported a case of a 60-year-old female with a 10-year history of gradually increasing mass in her left dorsal wrist. Read More

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http://dx.doi.org/10.1186/s12885-019-6293-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6836650PMC
November 2019

Aneurysmal Patellar Bone Cyst: Case Reportt.

Rev Bras Ortop (Sao Paulo) 2019 Sep 29;54(5):609-616. Epub 2019 Oct 29.

Hospital Santo Antônio, Blumenau, SC, Brasil.

Patellar tumors are rare. Commonly benign, giant-cell tumors and chondroblastomas are the most frequent types of this tumor. Aneurysmal bone cysts are a less common type, corresponding to less than 1% of the cases. Read More

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http://dx.doi.org/10.1016/j.rbo.2017.09.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6819161PMC
September 2019

Biomimetic Carriers Based on Giant Membrane Vesicles for Targeted Drug Delivery and Photodynamic/Photothermal Synergistic Therapy.

ACS Appl Mater Interfaces 2019 Nov 18;11(47):43811-43819. Epub 2019 Nov 18.

Molecular Science and Biomedicine Laboratory (MBL), State Key Laboratory of Chemo/Bio-Sensing and Chemometrics, College of Biology, College of Chemistry and Chemical Engineering, Aptamer Engineering Center of Hunan Province , Hunan University , Changsha , Hunan 410082 , China.

Membrane vesicles derived from live cells show great potential in biological applications due to their preserved cell membrane properties. Here, we demonstrate that cell-derived giant membrane vesicles can be used as vectors to deliver multiple therapeutic drugs and carry out combinational phototherapy for targeted cancer treatment. We show that therapeutic drugs can be efficiently encapsulated into giant membrane vesicles and delivered to target cells by membrane fusion, resulting in synergistic photodynamic/photothermal therapy under light irradiation. Read More

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http://dx.doi.org/10.1021/acsami.9b11223DOI Listing
November 2019

Endoscopic Transforaminal Transchoroidal Approach to the Third Ventricle for Cystic and Solid Tumors.

World Neurosurg 2020 Feb 24;134:e453-e459. Epub 2019 Oct 24.

Department of Neurosurgery, Radboud University, Nijmegen, Netherlands.

Background: Endoscopic access to the third ventricle is limited by the confinements of the foramen of Monro and can be aided by opening of the choroidal fissure.

Objective: We describe the endoscopic transforaminal transchoroidal (ETTC) approach to the third ventricle with opening of the choroidal fissure to enlarge the posterior foramen of Monro for treatment of various third ventricular diseases.

Methods: We completed a retrospective review of a prospectively collected database at 3 tertiary academic facilities. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.10.099DOI Listing
February 2020
2.417 Impact Factor

Local Tumor Recurrence and Escape from Suppression of Bone Resorption With Denosumab Treatment in Two Adolescents With Giant Cell Tumors of Bone.

JBMR Plus 2019 Sep 18;3(9):e10196. Epub 2019 Jun 18.

Pediatric Bone Health Clinical Research Program, Children's Hospital of Eastern Ontario Research Institute Ottawa Canada.

Giant cell tumors of bone (GCTB) may be difficult to resect because of size or location. We describe two adolescents who were treated with denosumab and followed for tumoral and biochemical responses. Denosumab was effective in achieving sufficient regression to allow surgical resection and in preserving peritumor cortical bone. Read More

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http://dx.doi.org/10.1002/jbm4.10196DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6808219PMC
September 2019
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Image-Guided Percutaneous Management of Skull and Spine Giant Cell Tumors: Case Report of 2 Challenging Cases Successfully Treated with Doxycycline Sclerotherapy.

World Neurosurg X 2020 Jan 25;5:100061. Epub 2019 Sep 25.

Department of Radiology, Nationwide Children's Hospital, Columbus, Ohio, USA.

Background: A giant cell tumor (GCT) of bone is a benign, locally aggressive tumor that is often challenging to treat. When complete resection is not possible, curettage with or without adjuvants is the most common treatment. The high frequency of local recurrence and risk of injury to adjacent structures can limit this surgical approach, especially with skull and spine lesions. Read More

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http://dx.doi.org/10.1016/j.wnsx.2019.100061DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6807377PMC
January 2020

Unusual manifestations of diffuse-type tenosynovial giant cell tumor in two patients: importance of radiologic-pathologic correlation.

Skeletal Radiol 2020 Mar 28;49(3):483-489. Epub 2019 Oct 28.

Department of Radiology, Mayo Clinic, Charlton Building North, 1st Floor, 200 First Street SW, Rochester, MN, 55905, USA.

Diffuse-type tenosynovial giant cell tumor (TSGCT) is a rare, locally aggressive neoplasm. It most commonly occurs in the knee, followed by the hip, and has distinctive imaging features, including mass-like foci of low T2 signal intensity, "blooming" on gradient-echo MRI, and pronounced uptake on FDG PET/CT. Histologically, TSGCT demonstrates a neoplastic population of mononuclear cells admixed with hemosiderin-laden macrophages, foamy histiocytes, inflammatory cells, and osteoclast-like giant cells. Read More

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http://dx.doi.org/10.1007/s00256-019-03325-7DOI Listing