3,327 results match your criteria Giant Cell Tumor Imaging


Denosumab versus zoledronic acid in cases of surgically unsalvageable giant cell tumor of bone: A randomized clinical trial.

J Bone Oncol 2019 Apr 23;15:100217. Epub 2019 Jan 23.

Department of Bone and Soft Tissue Tumor Surgery, Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute, No 44 of Xiaoheyan Road, Dadong District, Shenyang, Liaoning Province 110042, China.

Background: Although denosumab has been approved as an antiresorptive agent for giant cell tumor of bone, its efficacy has not been proven.

Objectives: To compare the efficacy and safety of denosumab and zoledronic acid treatment in patients with surgically unsalvageable giant cell tumor of bone.

Methods: A total of 250 patients with surgically unsalvageable giant cell tumor of bone were included in this randomized clinical trial. Read More

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http://dx.doi.org/10.1016/j.jbo.2019.100217DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357891PMC
April 2019
1 Read

Similar local recurrence but better function with curettage versus resection for bone giant cell tumor and pathological fracture at presentation.

J Surg Oncol 2019 Feb 7. Epub 2019 Feb 7.

Department of Orthopaedic Oncology, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy.

Background: There are conflicting reports for the outcome of the patients with giant cell tumor of bone (GCTB) and pathological fracture at presentation treated with curettage or resection. This study compared local recurrence, complications, and function after curettage versus resection for these patients.

Materials And Methods: We retrospectively studied the files of 46 patients with histologically confirmed GCTB of the extremities admitted and treated from 1982 to 2015. Read More

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http://dx.doi.org/10.1002/jso.25391DOI Listing
February 2019

Neoadjuvant denosumab.

Bone Joint J 2019 Feb;101-B(2):170-177

Tata Memorial Centre, HBNI, Mumbai, India.

Aims: The aims of this study were to evaluate the efficacy of preoperative denosumab in achieving prospectively decided intention of therapy in operable giant cell tumour of bone (GCTB) patients, and to document local recurrence-free survival (LRFS).

Patients And Methods: A total of 44 patients received preoperative denosumab: 22 to facilitate curettage, 16 to facilitate resection, and six with intent of converting resection to curettage. There were 26 male and 18 female patients. Read More

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http://dx.doi.org/10.1302/0301-620X.101B2.BJJ-2018-0907.R2DOI Listing
February 2019

An Unusual Case of Giant Cell Tumor of the Distal Tibia.

J Orthop Case Rep 2018 Jul-Aug;8(4):29-31

Department of Orthopedics, Epping Tristar Medical Centre, Australia.

Introduction: Giant cell tumors are common in proximal tibia and distal end radius and have a low tendency to recur. They have been treated successfully with excision and cementing or sandwich bone grafting without recurrence. Here, we present a rare case of giant cell tumor (GCT) of the distal tibia treated successfully with no recurrence at the end of 2 years. Read More

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http://dx.doi.org/10.13107/jocr.2250-0685.1144DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343573PMC
January 2019

Coexistence of giant cell tumor of tendon sheath and enchondroma in the middle phalanx of the little finger mimicking a malignant tumor: A case report.

Oncol Lett 2019 Feb 28;17(2):1969-1973. Epub 2018 Nov 28.

Department of Orthopedic Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Hiroshima 734-8551, Japan.

Giant cell tumor of the tendon sheath is a type of slow-growing benign soft tissue tumor that typically arises from the synovium of the tendon sheath. Enchondroma is a benign bone tumor comprising of mature hyaline cartilage that centrally develops within the tubular bone. While giant cell tumor of the tendon sheath or enchondroma are common benign soft tissue and bone tumors, respectively the simultaneous occurrence of these tumors in the same region of the hand is exceedingly rare, and it can mimic a malignant tumor, thereby making the diagnosis more challenging. Read More

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http://dx.doi.org/10.3892/ol.2018.9775DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341555PMC
February 2019

Tumor immunohistochemistry and preoperative magnetic resonance imaging features predict local recurrence of giant cell tumor of bone following intralesional curettage.

Oncol Lett 2019 Feb 30;17(2):1425-1434. Epub 2018 Nov 30.

Department of Radiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, P.R. China.

Giant cell tumor of bone (GCTB) is among the most prevalent types of tumor of the bone in East and Southeast Asia. The high rate of local recurrence following intralesional curettage poses a challenge for the clinical treatment of GCTB. In the present study, the expression of matrix metalloproteinase-9 (MMP-9), vascular endothelial growth factor (VEGF), receptor activator of nuclear factor-κB (RANK) and RANK ligand (RANKL) in GCTB was investigated by immunohistochemical staining. Read More

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http://www.spandidos-publications.com/10.3892/ol.2018.9778
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http://dx.doi.org/10.3892/ol.2018.9778DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341842PMC
February 2019
6 Reads

Reliability of imaging based diagnosis of lateral ventricular masses in children.

World Neurosurg 2019 Jan 17. Epub 2019 Jan 17.

Department of Neurological Sciences, Christian Medical College and Hospital, Vellore 632004, Tamil Nadu, India. Electronic address:

Objective: We studied the accuracy of the radiological diagnosis of lateral ventricular masses in children (<20 years of age).

Methods: In this retrospective study, data were collected from children with lateral ventricular masses managed in our unit between 2001 and 2016. There were 43 patients (26 males; 17 females; mean age, 12. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18788750193007
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http://dx.doi.org/10.1016/j.wneu.2018.12.196DOI Listing
January 2019
4 Reads

Surgical Treatment for a Giant Solitary Plasmacytoma with Skull Erosion.

Cureus 2018 Nov 1;10(11):e3535. Epub 2018 Nov 1.

Neurosurgery, Taipei Veterans General Hospital, Taipei, TWN.

Solitary plasmacytoma of the skull, a single malignant monoclonal plasma cell proliferation without systemic involvement, is rare and often misdiagnosed by radiological examinations only. In this article, the authors presented a 40-year-old man who had a painless protruding mass over the midline of the posterior head region. A brain magnetic resonance imaging (MRI) revealed an enhanced mass lesion over the midline of the parieto-occipital region with skull erosion. Read More

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http://dx.doi.org/10.7759/cureus.3535DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6319599PMC
November 2018
1 Read

[Current Status of Diagnosis and Treatment of Pulmonary Sarcomatoid Carcinoma].

Zhongguo Fei Ai Za Zhi 2018 Dec;21(12):902-906

Department of Thoracic Surgery, Nationanl Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, 
Chinese Academy of Medical Scienses and Peking Union Medical College, Beijing 100021, China.

Pulmonary sarcomatoid carcinoma (PSC) is a rare, poorly differentiated, subtype of non-small cell lung carcinoma (NSCLC) and constitutes approximately 0.1% to 0.5% of all lung malignancies. Read More

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http://dx.doi.org/10.3779/j.issn.1009-3419.2018.12.07DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6318565PMC
December 2018
1 Read

The penetrating properties of the tumor homing peptide LyP-1 in model lipid membranes.

J Pept Sci 2018 Dec 27:e3145. Epub 2018 Dec 27.

Department of Physics, Alexandru I. Cuza University, Iasi, Romania.

Cell-penetrating peptides (CPPs) have the property to cross the plasma membrane and enhance its permeability. CPPs were successfully used to deliver numerous cargoes such as drugs, proteins, nucleic acids, imaging and radiotherapeutic agents, gold and magnetic nanoparticles, or liposomes inside cells. Although CPPs were intensively investigated over the past 20 years, the exact molecular mechanisms of translocation across membranes are still controversial and vary from passive to active mechanisms. Read More

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http://doi.wiley.com/10.1002/psc.3145
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http://dx.doi.org/10.1002/psc.3145DOI Listing
December 2018
18 Reads

Bone Involvement Mimicking an Aggressive Bone Lesion in a Diffuse-type Tenosynovial Giant Cell Tumor in the Thoracic Vertebral Lamina: A Case Report.

J Orthop Case Rep 2018 May-Jun;8(3):14-17

Department of Orthopaedic Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

Introduction: Diffuse-type tenosynovial giant cell tumor (D-TGCT), or pigmented villonodular synovitis, is a benign, but aggressive lesion, primarily involving large joints. The spine is rarely affected, with the involvement of the thoracic spine being particularly rare. Massive bone involvement associated with facet joints is a characteristic of spinal D-TGCT. Read More

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http://dx.doi.org/10.13107/jocr.2250-0685.1088DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6298722PMC
December 2018

An Unusual Presentation of Giant Cell Tumor of the Tibia in a Skeletally Immature Patient.

J Orthop Case Rep 2018 May-Jun;8(3):10-13

Department of Pathology, JSS Medical College and Hospital, Mysore, Karnataka, India.

Introduction: Giant cell tumors (GCTs) are locally aggressive tumors that principally affect the epiphysis of long bones. Histologically, these tumors consist of three types of cells: Osteoclast-like multinucleated giant cells, round mononuclear cells resembling mononucleocytes, and spindle-shaped round fibroblast-like stromal cells. Radiographically, the tumors appear osteolytic and radiolucent without a sclerotic border. Read More

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http://dx.doi.org/10.13107/jocr.2250-0685.1086DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6298713PMC
December 2018
1 Read

Long-term follow-up of intensive chemotherapy followed by reduced-dose and reduced-field irradiation for intracranial germ cell tumor.

J Neurosurg Pediatr 2018 Nov 1:1-8. Epub 2018 Nov 1.

7Radiation Oncology, Mie University Graduate School of Medicine, Tsu City, Mie, Japan.

OBJECTIVEThe authors analyzed the efficacy of intensive chemotherapy followed by reduced-dose and reduced-field irradiation for intracranial germ cell tumors (GCTs) and evaluated the long-term late effects caused by chemoradiotherapy (CRT).METHODSThe authors performed a retrospective study. The subjects were 24 patients who received CRT between April 1994 and April 2015. Read More

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http://dx.doi.org/10.3171/2018.9.PEDS18181DOI Listing
November 2018
1 Read

Application of fused image in detecting abnormalities of temporomandibular joint.

Dentomaxillofac Radiol 2018 Dec 12:20180129. Epub 2018 Dec 12.

4 Center for Temporomandibular Disorders and Orofacial Pain, Peking University School and Hospital of Stomatology , Beijing , China.

Objectives:: To present a method for image fusion of cone beam CT (CBCT)/CT and MRI and to explore whether the image data sets fused in such a way could aid the detection of temporomandibular joint (TMJ) anatomical structures and lesions.

Methods:: There were five cases included in this study. One case was space occupying lesion giant cell tumour of tendon sheaths, one case was chronic inflammation in the condyle, one case was articular disc calcification of the bilateral TMJs, and the other two cases were TMJ disorders (anterior disc displacement without reduction). Read More

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https://www.birpublications.org/doi/10.1259/dmfr.20180129
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http://dx.doi.org/10.1259/dmfr.20180129DOI Listing
December 2018
2 Reads

Giant Cell Tumor of the Frontal Bone: A Case Report and Literature Review.

Cureus 2018 Sep 24;10(9):e3353. Epub 2018 Sep 24.

Neurosurgery, Advocate Good Samaritan Hospital, Downers Grove, USA.

Giant cell tumors are rare benign lesions that typically occur at the epiphyses of long bones in the extremities and present with pain or swelling. These lesions very seldom occur in the skull, where they preferentially affect the sphenoid and temporal bones that develop by endochondral ossification. We report a rare case of a giant cell tumor of the frontal bone and review the literature on these lesions. Read More

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https://www.cureus.com/articles/13786-giant-cell-tumor-of-th
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http://dx.doi.org/10.7759/cureus.3353DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6255713PMC
September 2018
16 Reads

Temporal Bone Tumors: An Imaging Update.

Neuroimaging Clin N Am 2019 Feb;29(1):145-172

Department of Radiology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, 243 Charles Street, Boston, MA 02114, USA.

In their variety, temporal bone tumors mirror the complexity of the structure from which they arise. They include more familiar lesions, such as vestibular schwannomas and paragangliomas, and also rarer neoplasms, such as nonvestibular schwannomas, sarcomas, giant cell tumors, Schneiderian papillomas, and endolymphatic sac tumors. Diagnostic imaging is invaluable in evaluating such lesions because they are typically challenging to access surgically and monitor clinically. Read More

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http://dx.doi.org/10.1016/j.nic.2018.09.007DOI Listing
February 2019
15 Reads

Giant sellar metastasis from renal cell carcinoma: A case report and literature review.

Medicine (Baltimore) 2018 Nov;97(47):e13376

Department of Neurosurgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China.

Rationale: Sellar metastasis is a rare and complex disease whose clinical features are strongly associated with the primary malignancy. Here, we present a rare case of giant sellar metastasis spread from renal cell carcinoma (RCC).

Patient Concerns: A 30-year-old Chinese woman was admitted to our Hospital, reporting headache, nasal congestion, nausea, vomiting, and a sharp decline in her right eye vision. Read More

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http://dx.doi.org/10.1097/MD.0000000000013376DOI Listing
November 2018
13 Reads

Management of large-vessel vasculitis.

Curr Opin Rheumatol 2019 Jan;31(1):25-31

Department of Internal Medicine, Division of Rheumatology, School of Medicine, Istanbul University - Cerrahpasa, Istanbul, Turkey.

Purpose Of Review: Glucocorticoids are the mainstay of therapy for large-vessel vasculitis, but potential toxicity and frequent relapses led to studies with nonbiologic and biologic glucocorticoid-sparing agents. The aim of this review is to discuss the recent evidence for the management of giant cell arteritis (GCA) and Takayasu arteritis (TAK).

Recent Findings: Tocilizumab proved to be a powerful glucocorticoid-sparing agent for GCA in a randomized placebo-controlled trial, whereas the trials with tocilizumab and abatacept failed to show a significant difference from placebo in relapse-free survival rate in TAK. Read More

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http://dx.doi.org/10.1097/BOR.0000000000000561DOI Listing
January 2019
12 Reads

Perivascular epithelioid cell tumor outgrowth from the liver.

Int J Surg Case Rep 2018 10;53:295-298. Epub 2018 Nov 10.

Departments of Transplantation, Baskent University, Ankara, Turkey. Electronic address:

Introduction: Perivascular epithelioid celltumor (PEComa) is a rare mesenchymal neoplasia and can be found in various body sites. On the other hand, hepatic PEComa is very rare, with only a few studies having reported hepatic malignant PEComa. There is no gold standard regarding the use of diagnostic imaging studies. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22102612183047
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http://dx.doi.org/10.1016/j.ijscr.2018.10.046DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6240724PMC
November 2018
9 Reads

Osteoclast-like giant cell rich carcinomas of the lung: a Clinicopathological, Immunohistochemical, and molecular study of three cases.

Hum Pathol 2018 Nov 14. Epub 2018 Nov 14.

Department of Pathology, the University of Texas, M D Anderson Cancer Center, Houston, TX. Electronic address:

Three cases of primary carcinomas of the lung each with an extensive osteoclast-like giant cell component are presented. The patients are three men between the ages of 58 and 67years (average: 62.5years) who presented with non-specific symptomatology. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00468177183042
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http://dx.doi.org/10.1016/j.humpath.2018.10.030DOI Listing
November 2018
9 Reads

A Triple-Classification Radiomics Model for the Differentiation of Primary Chordoma, Giant Cell Tumor, and Metastatic Tumor of Sacrum Based on T2-Weighted and Contrast-Enhanced T1-Weighted MRI.

J Magn Reson Imaging 2019 Mar 14;49(3):752-759. Epub 2018 Nov 14.

Department of Radiology, Peking University People's Hospital, Beijing, P. R. China.

Background: Preoperative differentiation between primary sacral chordoma (SC), sacral giant cell tumor (SGCT), and sacral metastatic tumor (SMT) is important for treatment decisions.

Purpose: To develop and validate a triple-classification radiomics model for the preoperative differentiation of SC, SGCT, and SMT based on T2-weighted fat saturation (T2w FS) and contrast-enhanced T1-weighted (CE T1w) MRI.

Study Type: Retrospective. Read More

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http://doi.wiley.com/10.1002/jmri.26238
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http://dx.doi.org/10.1002/jmri.26238DOI Listing
March 2019
8 Reads

Evaluation of a Novel General Pituitary Hormone Score to Evaluate the Function of the Residual Anterior Pituitary (Adenohypophysis) in Patients Following Surgery for Pituitary Adenoma.

Med Sci Monit 2018 Nov 6;24:7944-7951. Epub 2018 Nov 6.

Department of Neurosurgery, Fuzhou General Hospital, Fujian Medical University, Fuzhou, Fujian, China (mainland).

BACKGROUND The aim was to develop and assess a general pituitary hormone score to evaluate the function of the anterior pituitary (adenohypophysis) in patients following resection of pituitary adenomas. MATERIAL AND METHODS Sixty-six patients with pituitary null cell macroadenoma (1-3 cm diameter) (N=38) and pituitary null cell giant adenoma (≥3 cm diameter) (N=28) had preoperative and postoperative data including magnetic resonance imaging (MRI) and measurement of six pituitary hormones levels, adrenocorticotropic hormone (ACTH), growth hormone (GH), thyroid-stimulating hormone (TSH), prolactin (PRL), follicle-stimulating hormone (FSH), and luteinizing hormone (LH). The postoperative general pituitary hormone score, for 57 patients who underwent subtotal resection (>60%) and nine patients who underwent partial resection (≤60%), was 1-5 for each hormone level (score range, 6-30). Read More

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https://www.medscimonit.com/abstract/index/idArt/909925
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http://dx.doi.org/10.12659/MSM.909925DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6234753PMC
November 2018
6 Reads

Squamous cell carcinoma arising in a partially ruptured giant mature cystic teratoma: A case report.

Radiol Case Rep 2019 Jan 24;14(1):97-102. Epub 2018 Oct 24.

Cooper University Hospital, Department of Diagnostic Radiology, One Cooper Plaza, Camden, NJ 08103, USA.

Mature cystic teratomas are the most common ovarian germ cell tumors and represent 70% of the benign ovarian tumors occurring in women under age 30. In less than 2% of cases, these tumors can transform into malignancies. Squamous cell carcinoma arises most frequently from these tumors (in 80% of cases). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S19300433183041
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http://dx.doi.org/10.1016/j.radcr.2018.09.029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6204922PMC
January 2019
2 Reads

Long-term Follow-up of the Use of a Synthetic Bone Graft Composite in the Surgical Management of Primary Bone Tumors.

Orthopedics 2018 Nov 29;41(6):e868-e875. Epub 2018 Oct 29.

The surgical management of benign and benign aggressive bone tumors typically involves intralesional curettage and reconstruction of the resulting defect with cement or bone graft material. At the authors' institution, an injectable synthetic calcium sulfate-calcium phosphate composite is now the standard graft material for these cases. This study reports the long-term follow-up, specifically the stability of bone regeneration, for the use of the synthetic graft material for oncologic reconstruction. Read More

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https://www.healio.com/doiresolver?doi=10.3928/01477447-2018
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http://dx.doi.org/10.3928/01477447-20181023-03DOI Listing
November 2018
10 Reads

Arthroscopic Excision of Tendinous Giant Cell Tumors Causing Locking in the Knee Joint.

Acta Chir Orthop Traumatol Cech 2018 ;85(2):109-112

Istanbul Medipol University, Department of Orthopaedics and Traumatology, Istanbul, Turkey.

PURPOSE OF THE STUDY Non-osseous giant cell tumors are locally aggressive tumors arising around joints. They are commonly located around synovial joints such as wrist and knee and occasionally cause mechanical symptoms. MATERIAL AND METHODS This retrospective case series includes 7 patients operated due to intraarticular lesion. Read More

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January 2019
6 Reads

Large Multilocular Cystic Lesions in the Uterine Cervix: Differential Diagnosis and Significance.

J Med Ultrasound 2018 Jul-Sep;26(3):153-156. Epub 2018 May 7.

Department of Obstetrics and Gynecology, Faculty of Medicine, Alexandria University, Alexandria, Egypt.

Introduction: Cervical nabothian cysts are common in women of reproductive age. Although cysts are generally small and asymptomatic, large ones are extremely rare and may be misdiagnosed as malignancy.

Case Study: We report a case of large multiple complex nabothian cyst, which was suspected as malignant one on imaging and examination. Read More

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http://www.jmuonline.org/text.asp?2018/26/3/153/231989
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http://dx.doi.org/10.4103/JMU.JMU_38_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6159317PMC
May 2018
15 Reads

Comparison of radiomics machine-learning classifiers and feature selection for differentiation of sacral chordoma and sacral giant cell tumour based on 3D computed tomography features.

Eur Radiol 2018 Oct 2. Epub 2018 Oct 2.

Department of Radiology, Peking University People's Hospital, 11 Xizhimen Nandajie, Xicheng District, Beijing, 100044, People's Republic of China.

Objective: We aimed to identify optimal machine-learning methods for preoperative differentiation of sacral chordoma (SC) and sacral giant cell tumour (SGCT) based on 3D non-enhanced computed tomography (CT) and CT-enhanced (CTE) features.

Methods: A total of 95 patients were divided into a training set and a validation set. Three best feature selection methods (Relief, least absolute shrinkage and selection operator (LASSO) and Random Forest (RF)) and three classification methods, including generalised linear models (GLM), support vector machines (SVM) and RF, were compared for their performance in distinguishing SC and SGCT. Read More

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http://dx.doi.org/10.1007/s00330-018-5730-6DOI Listing
October 2018
1 Read

Diagnosis of tuberous sclerosis complex in the fetus.

Eur J Paediatr Neurol 2018 Nov 12;22(6):1027-1034. Epub 2018 Sep 12.

1st Department of Pediatrics, Developmental Center "A. Fokas", Aristotle University of Thessaloniki, "Hippokratio" General Hospital, Thessaloniki, Greece. Electronic address:

Tuberous sclerosis complex is a dominantly inherited genetic disorder of striking clinical variability. It is caused by mutations in either TSC1 or TSC2 gene, which regulate cell growth and proliferation by inhibition of mTORC1 signaling. TS is characterized by the development of benign tumors in many tissues and organs and its neurological manifestations include epilepsy, autism, cognitive and behavioral dysfunction, and giant cell tumors. Read More

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http://dx.doi.org/10.1016/j.ejpn.2018.08.005DOI Listing
November 2018
9 Reads

[Histopathological classification principles of rheumatic joint diseases : Contribution of pathology to the diagnosis].

Orthopade 2018 Nov;47(11):939-946

Unfallchirurgische Klinik, Sektion obere Extremität, Fuß- und Rheumachirurgie, Medizinische Hochschule Hannover, Hannover, Deutschland.

Even though the diagnostics of rheumatic joint diseases are mostly based on clinical, immunoserological and imaging criteria, histopathology can also make a significant contribution. This is particularly true for clinically unclear monoarticular and periarticular diseases. The contribution of histopathology to the diagnosis of rheumatic diseases is manifold since the histopathological differential diagnosis includes the complete spectrum of synovial diseases. Read More

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http://dx.doi.org/10.1007/s00132-018-3649-xDOI Listing
November 2018
2 Reads

Assessment of denosumab treatment effects and imaging response in patients with giant cell tumor of bone.

World J Surg Oncol 2018 Sep 19;16(1):191. Epub 2018 Sep 19.

Amgen Inc., Thousand Oaks, CA, USA.

Background: Denosumab has been shown to reduce tumor size and progression, reform mineralized bone, and increase intralesional bone density in patients with giant cell tumor of bone (GCTB); however, radiologic assessment of tumors in bone is challenging. The study objective was to assess tumor response to denosumab using three different imaging parameters in a prespecified analysis in patients with GCTB from two phase 2 studies.

Methods: The studies enrolled adults and adolescents (skeletally mature and at least 12 years of age) with radiographically measurable GCTB that were given denosumab 120 mg every 4 weeks, with additional doses on days 8 and 15 of cycle 1. Read More

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http://dx.doi.org/10.1186/s12957-018-1478-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6146657PMC
September 2018
6 Reads

Central nervous system manifestations of tuberous sclerosis complex.

Am J Med Genet C Semin Med Genet 2018 Sep 19;178(3):291-298. Epub 2018 Sep 19.

Department of Neurosurgery, Baylor College of Medicine, Houston, Texas.

Tuberous sclerosis complex (TSC) is a neurocutaneous autosomal-dominant genetic syndrome marked by development of hamartomatous lesions arising from dysfunction of the mammalian target of rapamycin (mTOR) pathway. Although TSC remains a heterogeneous clinical entity, the recent inclusion of genetic diagnostic criteria reflects advancement in our understanding of its underlying etiopathogenesis. Abnormal cellular growth, differentiation, and migration result in multisystem sequelae, with neurologic manifestations of TSC representing the primary cause of morbidity and mortality for the majority of individuals. Read More

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http://dx.doi.org/10.1002/ajmg.c.31647DOI Listing
September 2018
1 Read

Desmoplastic fibroblastoma mimicking tenosynovial giant cell tumor encasing a tendon of the foot.

Skeletal Radiol 2018 Sep 18. Epub 2018 Sep 18.

Department of Orthopaedic Surgery, CHA Bundang Medical Center, CHA University School of Medicine, 59, Yatap-ro, Bundang-gu, Seongnam-si, Gyeonggi-do, 13496, Republic of Korea.

Desmoplastic fibroblastoma is an uncommon, benign fibrous soft tissue tumor that usually occurs in the arms, shoulders, neck, hands, and feet in the fifth to seventh decades of life. In general, it is commonly located in the subcutaneous tissue and skeletal muscle. The authors report an unusual case of a desmoplastic fibroblastoma mimicking tenosynovial giant cell tumor encasing a tendon of the foot in a 72-year-old woman. Read More

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http://dx.doi.org/10.1007/s00256-018-3068-4DOI Listing
September 2018
2 Reads

Giant cell tumor of a rib following denosumab treatment.

Radiol Case Rep 2018 Oct 1;13(5):1018-1020. Epub 2018 Jun 1.

McGill University Health Centre, Department of Diagnostic Radiology, Montreal General Hospital, 1650 Cedar Avenue, Montreal, QC H3G 1A4, Canada.

Giant cell tumor (GCT) of the bone is an aggressive lytic lesion, commonly treated with surgery. Denosumab is a relatively recently introduced osteoclast activation inhibitor used for neoadjuvant therapy of GCT. Here we report the case of a GCT of a rib undergoing extensive osteosclerosis on computed tomography imaging following treatment with denosumab. Read More

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http://dx.doi.org/10.1016/j.radcr.2018.04.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6137337PMC
October 2018
1 Read

MRI assessment of the bone adjacent to giant cell tumours and its association with local recurrence after intralesional curettage.

Clin Radiol 2018 Nov 15;73(11):984.e19-984.e28. Epub 2018 Sep 15.

Department of Radiology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Electronic address:

Aim: To assess the tumour border surrounding giant cell tumour of the bone (GCTB) using magnetic resonance imaging (MRI) and investigate its association with local recurrence.

Materials And Methods: Sixty-nine GCTBs in proximal tibiae and distal femurs were studied. The pathological basis of the paintbrush border sign was explored. Read More

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http://dx.doi.org/10.1016/j.crad.2018.06.021DOI Listing
November 2018
1 Read

The predictive value of preoperative neutrophil-lymphocyte ratio (NLR) on the recurrence of the local pigmented villonodular synovitis of the knee joint.

BMC Musculoskelet Disord 2018 Sep 19;19(1):339. Epub 2018 Sep 19.

Division of orthopaedic surgery, Huashan Hospital, Fudan University, Shanghai, 200040, China.

Background: To explore and evaluate the predictive value of preoperative Neutrophil-lymphocyte ratio (NLR) on the recurrence of pigmented villonodular synovitis (PVNS) of the knee joint treated by arthroscopic surgery combining local radiotherapy.

Methods: Sixty pathological-proven PVNS cases of the knee joint in our department from April 2006 to March 2017 were included. All of them are treated by arthroscopic synovectomy combined with adjuvant radiotherapy. Read More

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http://dx.doi.org/10.1186/s12891-018-2258-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6145334PMC
September 2018
10 Reads

[Visceral parasitic migration of liver: a clinicopathologic analysis of seven cases].

Zhonghua Bing Li Xue Za Zhi 2018 Sep;47(9):710-713

Department of Pathology, the Affiliated Drum Tower Hospital of Medical School of Nanjing University, Nanjing 210008, China.

To investigate the clinical, radiological and pathological features of visceral parasitic migration of the liver. Seven cases of visceral parasitic migration of liver were identified at the Affiliated Drum Tower Hospital of Medical School of Nanjing University from January 2008 to July 2017. Clinical data, enhanced CT image and pathological features were analyzed, combining with literature review. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0529-5807.2018.09.012DOI Listing
September 2018
1 Read

Applications of PET/CT and PET/MR Imaging in Primary Bone Malignancies.

PET Clin 2018 Oct 17;13(4):623-634. Epub 2018 Aug 17.

Division of Nuclear Medicine, Department of Radiology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90007, USA.

Primary bone malignancies are characterized with anatomic imaging. However, in recent years, there has been an increased interest in PET/computed tomography scanning and PET/MRI with fludeoxyglucose F 18 for evaluating and staging musculoskeletal neoplasms. These hybrid imaging modalities have shown promise largely owing to their high sensitivity, ability to perform more thorough staging, and ability to monitor treatment response. Read More

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http://dx.doi.org/10.1016/j.cpet.2018.05.012DOI Listing
October 2018
14 Reads

Severity classification of Tenosynovial Giant Cell Tumours on MR imaging.

Surg Oncol 2018 Sep 3;27(3):544-550. Epub 2018 Jul 3.

Orthopaedic Surgery, Leiden University Medical Center, Leiden, the Netherlands. Electronic address:

Aim: Current development of novel systemic agents requires identification and monitoring of extensive Tenosynovial Giant Cell Tumours (TGCT). This study defines TGCT extension on MR imaging to classify severity.

Methods: In part one, six MR parameters were defined by field-experts to assess disease extension on MR images: type of TGCT, articular involvement, cartilage-covered bone invasion, and involvement of muscular/tendinous tissue, ligaments or neurovascular structures. Read More

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http://dx.doi.org/10.1016/j.suronc.2018.07.002DOI Listing
September 2018
1 Read

Total spondylectomy for Enneking stage III giant cell tumor of the mobile spine.

Eur Spine J 2018 Sep 12. Epub 2018 Sep 12.

Department of Orthopaedic Surgery, Graduate School of Medical Science, Kanazawa University, 13-1 Takara-machi, Kanazawa, 920-8641, Japan.

Purpose: We reported the surgical outcomes of total en bloc spondylectomy (TES) with intralesional T-saw transpedicular osteotomy in patients with Enneking stage III spinal giant cell tumors (GCTs).

Methods: The medical records and imaging and pathological studies of 25 consecutive patients with Enneking stage III spinal GCTs undergoing surgery at our institution who were followed for at least 2 years were retrospectively reviewed.

Results: Eight men and 17 women (mean age: 34. Read More

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http://dx.doi.org/10.1007/s00586-018-5761-3DOI Listing
September 2018
1 Read

Intra-articular fibroma-like perivascular epithelioid tumor (PEComa) mimicking tenosynovial giant cell tumor, diffuse type.

Skeletal Radiol 2018 Sep 11. Epub 2018 Sep 11.

Division of Musculoskeletal Imaging and Intervention, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Yawkey 6E, 55 Fruit Street, Boston, MA, 02114, USA.

Perivascular epithelioid cell tumors (PEComas) are rare mesenchymal neoplasms composed of perivascular epithelioid cells that are immunoreactive for both melanocytic and myogenic markers. Recently, a fibroma-like PEComa associated with tuberous sclerosis complex (TSC) has been identified. We describe the first intra-articular case of a fibroma-like PEComa in a 44-year-old man who presented with a hypointense intra-articular knee mass, which was mistaken for tenosynovial giant cell tumor, diffuse type. Read More

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http://link.springer.com/10.1007/s00256-018-3065-7
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http://dx.doi.org/10.1007/s00256-018-3065-7DOI Listing
September 2018
13 Reads

Modified Lemaire extra-articular stabilisation of the knee for the treatment of anterolateral instability combined with diffuse pigmented villonodular synovitis: a case report.

BMC Musculoskelet Disord 2018 Sep 11;19(1):330. Epub 2018 Sep 11.

Department of Orthopedic and Trauma Surgery, Medical Center - Albert-Ludwigs-University of Freiburg, Faculty of Medicine, Albert-Ludwigs-University of Freiburg, Freiburg im Breisgau, Germany.

Background: Diffuse pigmented villonodular synovitis (PVNS) of the knee is a rare proliferative joint disease associated with high recurrence rates following surgical treatment. Intra-articular joint instability in conjunction with PVNS implies complex reconstructive strategies due to the destructive nature of the disease.

Case Presentation: Here, we present the case of a young patient with refractory PVNS and a chronic ipsilateral anterior cruciate ligament (ACL) rupture. Read More

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https://bmcmusculoskeletdisord.biomedcentral.com/articles/10
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http://dx.doi.org/10.1186/s12891-018-2248-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6134778PMC
September 2018
18 Reads

Fine needle aspiration of giant cell tumor involving thyroid gland: A case report of an unprecedented entity.

Diagn Cytopathol 2018 Oct 26;46(10):879-882. Epub 2018 Aug 26.

Department of Pathology, West China Hospital of Sichuan University, Chengdu, China.

Fine-needle aspiration (FNA) is commonly used to evaluate both primary thyroid lesions (PTLs) and secondary thyroid neoplasms (STNs). Although STNs are uncommon, metastases from various primary sites particularly the kidney, lung, and breast have been previously described. Giant cell tumor (GCT) is typically found in the metaphyseal-epiphyseal area of long bones that seldom involves thyroid. Read More

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http://dx.doi.org/10.1002/dc.24053DOI Listing
October 2018
1 Read

A Rare Incidence of Pigmented Villonodular Synovitis of the Ankle in an Adolescent.

J Foot Ankle Surg 2018 Nov - Dec;57(6):1263-1266. Epub 2018 Aug 23.

Assistant Professor, Department of Orthopaedic Surgery, Stony Brook University Hospital, Stony Brook, NY. Electronic address:

Pigmented villonodular synovitis mostly affects the knee and other large joints such as the hip. Although the disease is most commonly found in adult patients aged 30 to 40 years, rare cases in children and the elderly have been reported. We present the case of an 11-year-old female who was found to have biopsy-proven pigmented villonodular synovitis in her subtalar joint in 2012. Read More

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http://dx.doi.org/10.1053/j.jfas.2018.03.029DOI Listing
August 2018
1 Read

MRI of intracranial intraventricular lesions.

Clin Imaging 2018 Nov - Dec;52:226-239. Epub 2018 Aug 1.

Vancouver General Hospital, 899 W 12th Ave, Vancouver, BC V5Z 1M9, Canada.

The MRI appearance of intraventricular neoplasms is often nonspecific, however knowledge of patient age and tumor location facilitates the formulation of a differential diagnosis. Imaging and pertinent clinical features of the following intraventricular neoplasms are reviewed: ependymoma, subependymoma, central neurocytoma, subependymal giant cell tumor, choroid plexus tumors, medulloblastoma, meningioma, chordoid glioma, rosette-forming glioneuronal tumor, central nervous system lymphoma, and metastasis. Read More

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http://dx.doi.org/10.1016/j.clinimag.2018.07.021DOI Listing
January 2019
6 Reads

Diagnostic Immunohistochemistry for Soft Tissue and Bone Tumors: An Update.

Adv Anat Pathol 2018 Nov;25(6):400-412

Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.

Although some soft tissue and bone tumors can be identified based on histologic features alone, immunohistochemistry plays a critical diagnostic role for most mesenchymal tumor types. The discovery of recurrent genomic alterations in many benign and malignant mesenchymal neoplasms has added important biologic insights and expanded the spectrum of some diagnostic subgroups. Some tumors are defined by unique genomic alterations, whereas others share abnormalities that are not tumor-specific and can be observed in a sometimes broad range of biologically unrelated neoplasms. Read More

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http://dx.doi.org/10.1097/PAP.0000000000000204DOI Listing
November 2018
16 Reads

[Treatment of proximal femoral benign lesions by proximal femoral nail anti-rotation combined with curettage and bone graft through the Watson-Jones approach].

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 2018 Jul;32(7):893-898

Department of Orthopedics, West China Hospital, Sichuan University, Chengdu Sichuan, 610041,

Objective: To evaluate the feasibility and effectiveness of proximal femoral nail anti-rotation (PFNA) combined with curettage and bone graft through Watson-Jones approach in the treatment of proximal femur benign tumors and tumor like lesions.

Methods: The clinical data of 38 patients with benign tumors and tumor like lesions in the proximal femur who were treated through the Watson-Jones approach with PFNA combined with curettage and bone graft between January 2008 and January 2015 were retrospective analysed. There were 24 males and 14 females with an average age of 28 years (range, 15-57 years). Read More

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http://dx.doi.org/10.7507/1002-1892.201801128DOI Listing
July 2018
11 Reads

Imaging findings in the progression of a giant cell glioblastoma.

Radiol Case Rep 2018 Oct 14;13(5):1007-1011. Epub 2018 Aug 14.

The University of Texas Medical Branch, 301 University Blvd., Galveston, TX 77555, USA.

First described in 1909, giant cell glioblastoma (GC) is a histologic variant of glioblastoma multiforme (GBM) that accounts for 1% of cases of primary GBM. It is characterized by a predominance of bizarre giant cells with abundant eosinophilic cytoplasm, and may portend an improved prognosis over classic GBM. Due to the rarity of GC, there is a paucity of reports that describe its associated radiologic findings. Read More

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http://dx.doi.org/10.1016/j.radcr.2018.07.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6097408PMC
October 2018
13 Reads

The utility of FDG-PET/CT imaging in the evaluation of multicentric reticulohistiocytosis: A case report.

Medicine (Baltimore) 2018 Aug;97(33):e11449

Department of Rheumatology.

Introduction: Multicentric reticulohistiocytosis (MRH) is a rare histiocytic disorder that involves the skin, joints, and visceral organs.

Case Presentation: We report a 67-year-old woman with MRH who presented with a 2-years history of polyarthralgia and skin nodules. Her symptoms were an inflammatory polyarthropathy with punched-out lesions of the distal interphalangeal (DIP) joints of both hands. Read More

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http://dx.doi.org/10.1097/MD.0000000000011449DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6112898PMC
August 2018
14 Reads

Denosumab in patients with aneurysmal bone cysts: A case series with preliminary results.

Tumori 2018 Oct 8;104(5):344-351. Epub 2018 Aug 8.

1 Chemotherapy Unit, IRCCS, Istituto Ortopedico Rizzoli, Bologna, Italy.

Purpose:: Aneurysmal bone cyst (ABC) is a rare skeletal tumor usually treated with surgery/embolization. We hypothesized that owing to similarities with giant cell tumor of bone (GCTB), denosumab was active also in ABC.

Methods:: In this observational study, a retrospective analysis of ABC patients treated with denosumab was performed. Read More

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http://dx.doi.org/10.1177/0300891618784808DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6247581PMC
October 2018
14 Reads

Preoperative Cytoreduction of Clival Giant Cell Tumor: An Effective Replication of the Systemic Modality in the Skull Base.

World Neurosurg 2018 Nov 1;119:97-102. Epub 2018 Aug 1.

Department of Neurosurgery, Sakra World Hospital, Bangalore, India.

Background: Giant cell tumors (GCTs) are benign tumors with a predilection for the epimetaphyseal region of the long bones. GCTs involving the skull base are rare, and only a few available cases have been reported. Surgical gross total resection is the recommended method of treatment for GCTs. Read More

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http://dx.doi.org/10.1016/j.wneu.2018.07.207DOI Listing
November 2018
7 Reads