3,349 results match your criteria Giant Cell Tumor Imaging


Deep palmar tumorous conditions of the hand.

J Orthop Surg (Hong Kong) 2019 May-Aug;27(2):2309499019840736

2 Hand Microsurgery Orthopaedics and Traumatology (EMOT) Hospital, Izmir, Turkey.

Purpose:: Deep palmar tumors of the hand are very rare, and reported cases are usually benign. The most important issue is frequent anatomical variations with challenging surgical exposure and excision of these lesions. Some case reports or a small series of patients have been reported in the literature. Read More

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http://journals.sagepub.com/doi/10.1177/2309499019840736
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http://dx.doi.org/10.1177/2309499019840736DOI Listing
April 2019
2 Reads

Measurement of morphological parameters of giant cell tumor of bone in the knee.

Oncol Lett 2019 Apr 21;17(4):3867-3873. Epub 2019 Feb 21.

Department of Bone Tumors, Tianjin Hospital, Tianjin 300211, P.R. China.

The aim of the present study was to characterize the morphological parameters of giant cell tumor of bone (GCTB) in the knee. The imaging data of 250 patients with GCTB in the knee were retrospectively reviewed, and the morphological parameters were analyzed. The study included 137 cases with GCTB in the distal femur and 113 cases with GCTB in the proximal tibia. Read More

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http://dx.doi.org/10.3892/ol.2019.10064DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425395PMC

Myoepithelial carcinoma of tibia mimic giant cell tumor: a case report with emphasis on MR features.

Skeletal Radiol 2019 Mar 13. Epub 2019 Mar 13.

Department of Medical Imaging, Chi Mei Medical Center, No. 901, Zhonghua Rd., Yongkang Dist., Tainan City, 710, Taiwan.

Intraosseous myoepithelial carcinoma is an extremely rare type of bone tumor that most often presents in the long tubular bones, but also occurs in small tubular bones and the axial skeleton. We report the radiographic images and complete magnetic resonance (MR) features of a 44-year-old male with right knee pain of 7 months' duration. The radiographic findings and convention MR images indicated a giant cell tumor of the bone. Read More

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http://dx.doi.org/10.1007/s00256-019-03198-wDOI Listing

T2*-weighted MR imaging findings of giant cell tumors of bone: radiological-pathological correlation.

Jpn J Radiol 2019 Mar 11. Epub 2019 Mar 11.

Department of Radiology, Gifu University School of Medicine, 1-1 Yanagido, Gifu, 501-1194, Japan.

Purpose: To assess the correlation between T2*-weighted MR imaging and pathological findings of giant cell tumors (GCT) of bone.

Methods: Of the 33 patients with histopathologically proven GCT of bone, 12 were examined using 1.5-T MR imaging, including T2*-weighted imaging, and were included in this study. Read More

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http://dx.doi.org/10.1007/s11604-019-00829-zDOI Listing

Convolutional neural network to predict the local recurrence of giant cell tumor of bone after curettage based on pre-surgery magnetic resonance images.

Eur Radiol 2019 Mar 11. Epub 2019 Mar 11.

Radiology Department, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, HaiNing Rd.100, Shanghai, 200080, China.

Objective: To predict the local recurrence of giant cell bone tumors (GCTB) on MR features and the clinical characteristics after curettage using a deep convolutional neural network (CNN).

Methods: MR images were collected from 56 patients with histopathologically confirmed GCTB after curettage who were followed up for 5.8 years (range, 2. Read More

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http://link.springer.com/10.1007/s00330-019-06082-2
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http://dx.doi.org/10.1007/s00330-019-06082-2DOI Listing
March 2019
3 Reads

Cu and fluorescein labeled anti-miRNA peptide nucleic acids for the detection of miRNA expression in living cells.

Sci Rep 2019 Mar 4;9(1):3376. Epub 2019 Mar 4.

Nuclear Medicine Unit, Oncology and Advanced Technologies Department, Azienda Unità Sanitaria Locale-IRCCS di Reggio Emilia, 42123, Reggio Emilia, Italy.

MiRNAs are single stranded RNAs of 18-22 nucleotides. They are promising diagnostic and prognostic markers for several pathologies including tumors, neurodegenerative, cardiovascular and autoimmune diseases. In the present work the development and characterization of anti-miRNA radiolabeled probes based on peptide nucleic acids (PNAs) for potential non-invasive molecular imaging in vivo of giant cell arteritis are described. Read More

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http://dx.doi.org/10.1038/s41598-018-35800-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6399270PMC
March 2019
3 Reads

Giant multilocular prostatic cystadenoma.

World J Surg Oncol 2019 Feb 26;17(1):42. Epub 2019 Feb 26.

Department of Colorectal Surgery, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 1040045, Japan.

Background: The giant multilocular prostatic cystadenoma is a very rare benign tumor of the prostate gland. It is composed of predominantly cystic enlarged prostatic glands in a fibrous stroma and spreads extensively into the pelvis. Because of the large size at the time of diagnosis, it is not always possible to determine the exact point of origin for these multilocular cystic neoplasms. Read More

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http://dx.doi.org/10.1186/s12957-019-1579-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6391754PMC
February 2019
5 Reads

Does Denosumab Change the Giant Cell Tumor Treatment Strategy? Lessons Learned From Early Experience.

Clin Orthop Relat Res 2018 Sep;476(9):1773-1782

M. G. Agarwal, M. K. Gundavda, R. Reddy, Orthopedic Oncology, PD Hinduja Hospital and Medical Research Center, Mumbai, India R. Gupta, Orthopedic Oncology, Fortis Hospital Mohali, India.

Background: Although giant cell tumors (GCTs) are benign, their aggressiveness and tendency to recur locally challenge the orthopaedic surgeon's ability to perform joint-preserving intralesional surgery with an acceptably low risk of local recurrence. Denosumab has emerged as a possible medical treatment of GCT because it seems to halt the progression of GCT, alleviate pain, and increase perilesional bone formation, but its exact role has been questioned, and specifically its efficacy and associated complications are not well characterized.

Questions/purposes: (1) Does denosumab reduce the risk of recurrence after resection or intralesional surgery? (2) What are the complications associated with the use of denosumab?

Methods: Fifty-four patients with 30 primary and 25 recurrent tumors between November 2013 and July 2016 were treated with denosumab after a confirmed histopathologic diagnosis of GCT. Read More

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http://dx.doi.org/10.1007/s11999.0000000000000243DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6259809PMC
September 2018
5 Reads

Giant Cell Tumor of the Tendon Sheath (GCTTS) with Multiple Bone Destruction of Different States: A Case Report.

J Hand Surg Asian Pac Vol 2019 Mar;24(1):110-115

1 Department of Orthopedic Surgery, Dongguk University Ilsan Hospital, Dongguk University College of Medicine, Goyang, Korea.

Giant cell tumour of tendon sheath (GCTTS) is considered benign, but well known for its high recurrence rate. Bone involvement of GCTTS is not uncommon and closely related to local recurrence after surgery. Radiologic findings of bone involvement are pressure erosion, circumscribed cortical destruction and degenerative arthritis. Read More

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http://dx.doi.org/10.1142/S2424835519720068DOI Listing
March 2019
1 Read

Denosumab versus zoledronic acid in cases of surgically unsalvageable giant cell tumor of bone: A randomized clinical trial.

J Bone Oncol 2019 Apr 23;15:100217. Epub 2019 Jan 23.

Department of Bone and Soft Tissue Tumor Surgery, Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute, No 44 of Xiaoheyan Road, Dadong District, Shenyang, Liaoning Province 110042, China.

Background: Although denosumab has been approved as an antiresorptive agent for giant cell tumor of bone, its efficacy has not been proven.

Objectives: To compare the efficacy and safety of denosumab and zoledronic acid treatment in patients with surgically unsalvageable giant cell tumor of bone.

Methods: A total of 250 patients with surgically unsalvageable giant cell tumor of bone were included in this randomized clinical trial. Read More

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http://dx.doi.org/10.1016/j.jbo.2019.100217DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357891PMC
April 2019
1 Read

Similar local recurrence but better function with curettage versus resection for bone giant cell tumor and pathological fracture at presentation.

J Surg Oncol 2019 Feb 7. Epub 2019 Feb 7.

Department of Orthopaedic Oncology, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy.

Background: There are conflicting reports for the outcome of the patients with giant cell tumor of bone (GCTB) and pathological fracture at presentation treated with curettage or resection. This study compared local recurrence, complications, and function after curettage versus resection for these patients.

Materials And Methods: We retrospectively studied the files of 46 patients with histologically confirmed GCTB of the extremities admitted and treated from 1982 to 2015. Read More

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http://dx.doi.org/10.1002/jso.25391DOI Listing
February 2019
1 Read

Neoadjuvant denosumab: its role and results in operable cases of giant cell tumour of bone.

Bone Joint J 2019 02;101-B(2):170-177

Tata Memorial Centre, HBNI, Mumbai, India.

Aims: The aims of this study were to evaluate the efficacy of preoperative denosumab in achieving prospectively decided intention of therapy in operable giant cell tumour of bone (GCTB) patients, and to document local recurrence-free survival (LRFS).

Patients And Methods: A total of 44 patients received preoperative denosumab: 22 to facilitate curettage, 16 to facilitate resection, and six with intent of converting resection to curettage. There were 26 male and 18 female patients. Read More

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http://dx.doi.org/10.1302/0301-620X.101B2.BJJ-2018-0907.R2DOI Listing
February 2019
1 Read

An Unusual Case of Giant Cell Tumor of the Distal Tibia.

J Orthop Case Rep 2018 Jul-Aug;8(4):29-31

Department of Orthopedics, Epping Tristar Medical Centre, Australia.

Introduction: Giant cell tumors are common in proximal tibia and distal end radius and have a low tendency to recur. They have been treated successfully with excision and cementing or sandwich bone grafting without recurrence. Here, we present a rare case of giant cell tumor (GCT) of the distal tibia treated successfully with no recurrence at the end of 2 years. Read More

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http://dx.doi.org/10.13107/jocr.2250-0685.1144DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343573PMC
January 2019

Coexistence of giant cell tumor of tendon sheath and enchondroma in the middle phalanx of the little finger mimicking a malignant tumor: A case report.

Oncol Lett 2019 Feb 28;17(2):1969-1973. Epub 2018 Nov 28.

Department of Orthopedic Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Hiroshima 734-8551, Japan.

Giant cell tumor of the tendon sheath is a type of slow-growing benign soft tissue tumor that typically arises from the synovium of the tendon sheath. Enchondroma is a benign bone tumor comprising of mature hyaline cartilage that centrally develops within the tubular bone. While giant cell tumor of the tendon sheath or enchondroma are common benign soft tissue and bone tumors, respectively the simultaneous occurrence of these tumors in the same region of the hand is exceedingly rare, and it can mimic a malignant tumor, thereby making the diagnosis more challenging. Read More

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http://dx.doi.org/10.3892/ol.2018.9775DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341555PMC
February 2019

Tumor immunohistochemistry and preoperative magnetic resonance imaging features predict local recurrence of giant cell tumor of bone following intralesional curettage.

Oncol Lett 2019 Feb 30;17(2):1425-1434. Epub 2018 Nov 30.

Department of Radiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, P.R. China.

Giant cell tumor of bone (GCTB) is among the most prevalent types of tumor of the bone in East and Southeast Asia. The high rate of local recurrence following intralesional curettage poses a challenge for the clinical treatment of GCTB. In the present study, the expression of matrix metalloproteinase-9 (MMP-9), vascular endothelial growth factor (VEGF), receptor activator of nuclear factor-κB (RANK) and RANK ligand (RANKL) in GCTB was investigated by immunohistochemical staining. Read More

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http://www.spandidos-publications.com/10.3892/ol.2018.9778
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http://dx.doi.org/10.3892/ol.2018.9778DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341842PMC
February 2019
13 Reads

Reliability of Imaging-Based Diagnosis of Lateral Ventricular Masses in Children.

World Neurosurg 2019 Jan 17. Epub 2019 Jan 17.

Department of Neurological Sciences, Christian Medical College and Hospital, Vellore, Tamil Nadu, India. Electronic address:

Objective: We studied the accuracy of the radiologic diagnosis of lateral ventricular masses in children (<20 years of age).

Methods: In this retrospective study, data were collected from children with lateral ventricular masses managed in our unit between 2001 and 2016. There were 43 patients (26 boys and 17 girls; mean age, 12. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18788750193007
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http://dx.doi.org/10.1016/j.wneu.2018.12.196DOI Listing
January 2019
13 Reads

Surgical Treatment for a Giant Solitary Plasmacytoma with Skull Erosion.

Cureus 2018 Nov 1;10(11):e3535. Epub 2018 Nov 1.

Neurosurgery, Taipei Veterans General Hospital, Taipei, TWN.

Solitary plasmacytoma of the skull, a single malignant monoclonal plasma cell proliferation without systemic involvement, is rare and often misdiagnosed by radiological examinations only. In this article, the authors presented a 40-year-old man who had a painless protruding mass over the midline of the posterior head region. A brain magnetic resonance imaging (MRI) revealed an enhanced mass lesion over the midline of the parieto-occipital region with skull erosion. Read More

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http://dx.doi.org/10.7759/cureus.3535DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6319599PMC
November 2018
2 Reads

Diffuse-Type Tenosynovial Giant Cell Tumor of the Shoulder Evaluated by FDG PET/CT.

Clin Nucl Med 2019 Apr;44(4):310-312

Nuclear Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.

Diffuse-type tenosynovial giant cell tumor is a locally aggressive neoplasm that typically involves the knee and hip but rarely involves the shoulder. In this case, a 74-year-old woman presented a painless mass in the right shoulder. FDG PET/CT demonstrated intense FDG uptake with an SUVmax of 19. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002451DOI Listing
April 2019
12 Reads

[Current Status of Diagnosis and Treatment of Pulmonary Sarcomatoid Carcinoma].

Zhongguo Fei Ai Za Zhi 2018 Dec;21(12):902-906

Department of Thoracic Surgery, Nationanl Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, 
Chinese Academy of Medical Scienses and Peking Union Medical College, Beijing 100021, China.

Pulmonary sarcomatoid carcinoma (PSC) is a rare, poorly differentiated, subtype of non-small cell lung carcinoma (NSCLC) and constitutes approximately 0.1% to 0.5% of all lung malignancies. Read More

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http://dx.doi.org/10.3779/j.issn.1009-3419.2018.12.07DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6318565PMC
December 2018
1 Read

The penetrating properties of the tumor homing peptide LyP-1 in model lipid membranes.

J Pept Sci 2019 Mar 27;25(3):e3145. Epub 2018 Dec 27.

Department of Physics, Alexandru I. Cuza University, Iasi, Romania.

Cell-penetrating peptides (CPPs) have the property to cross the plasma membrane and enhance its permeability. CPPs were successfully used to deliver numerous cargoes such as drugs, proteins, nucleic acids, imaging and radiotherapeutic agents, gold and magnetic nanoparticles, or liposomes inside cells. Although CPPs were intensively investigated over the past 20 years, the exact molecular mechanisms of translocation across membranes are still controversial and vary from passive to active mechanisms. Read More

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http://doi.wiley.com/10.1002/psc.3145
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http://dx.doi.org/10.1002/psc.3145DOI Listing
March 2019
24 Reads

Bone Involvement Mimicking an Aggressive Bone Lesion in a Diffuse-type Tenosynovial Giant Cell Tumor in the Thoracic Vertebral Lamina: A Case Report.

J Orthop Case Rep 2018 May-Jun;8(3):14-17

Department of Orthopaedic Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

Introduction: Diffuse-type tenosynovial giant cell tumor (D-TGCT), or pigmented villonodular synovitis, is a benign, but aggressive lesion, primarily involving large joints. The spine is rarely affected, with the involvement of the thoracic spine being particularly rare. Massive bone involvement associated with facet joints is a characteristic of spinal D-TGCT. Read More

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http://dx.doi.org/10.13107/jocr.2250-0685.1088DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6298722PMC
December 2018

An Unusual Presentation of Giant Cell Tumor of the Tibia in a Skeletally Immature Patient.

J Orthop Case Rep 2018 May-Jun;8(3):10-13

Department of Pathology, JSS Medical College and Hospital, Mysore, Karnataka, India.

Introduction: Giant cell tumors (GCTs) are locally aggressive tumors that principally affect the epiphysis of long bones. Histologically, these tumors consist of three types of cells: Osteoclast-like multinucleated giant cells, round mononuclear cells resembling mononucleocytes, and spindle-shaped round fibroblast-like stromal cells. Radiographically, the tumors appear osteolytic and radiolucent without a sclerotic border. Read More

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http://dx.doi.org/10.13107/jocr.2250-0685.1086DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6298713PMC
December 2018
2 Reads

Long-term follow-up of intensive chemotherapy followed by reduced-dose and reduced-field irradiation for intracranial germ cell tumor.

J Neurosurg Pediatr 2018 11;23(3):317-324

Radiation Oncology, Mie University Graduate School of Medicine, Tsu City, Mie, Japan.

OBJECTIVE The authors analyzed the efficacy of intensive chemotherapy followed by reduced-dose and reduced-field irradiation for intracranial germ cell tumors (GCTs) and evaluated the long-term late effects caused by chemoradiotherapy (CRT). METHODS The authors performed a retrospective study. The subjects were 24 patients who received CRT between April 1994 and April 2015. Read More

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http://dx.doi.org/10.3171/2018.9.PEDS18181DOI Listing
November 2018
5 Reads

Application of fused image in detecting abnormalities of temporomandibular joint.

Dentomaxillofac Radiol 2019 Mar 12;48(3):20180129. Epub 2018 Dec 12.

4 Center for Temporomandibular Disorders and Orofacial Pain, Peking University School and Hospital of Stomatology , Beijing , China.

Objectives:: To present a method for image fusion of cone beam CT (CBCT)/CT and MRI and to explore whether the image data sets fused in such a way could aid the detection of temporomandibular joint (TMJ) anatomical structures and lesions.

Methods:: There were five cases included in this study. One case was space occupying lesion giant cell tumour of tendon sheaths, one case was chronic inflammation in the condyle, one case was articular disc calcification of the bilateral TMJs, and the other two cases were TMJ disorders (anterior disc displacement without reduction). Read More

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https://www.birpublications.org/doi/10.1259/dmfr.20180129
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http://dx.doi.org/10.1259/dmfr.20180129DOI Listing
March 2019
6 Reads

Giant Cell Tumor of the Frontal Bone: A Case Report and Literature Review.

Cureus 2018 Sep 24;10(9):e3353. Epub 2018 Sep 24.

Neurosurgery, Advocate Good Samaritan Hospital, Downers Grove, USA.

Giant cell tumors are rare benign lesions that typically occur at the epiphyses of long bones in the extremities and present with pain or swelling. These lesions very seldom occur in the skull, where they preferentially affect the sphenoid and temporal bones that develop by endochondral ossification. We report a rare case of a giant cell tumor of the frontal bone and review the literature on these lesions. Read More

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https://www.cureus.com/articles/13786-giant-cell-tumor-of-th
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http://dx.doi.org/10.7759/cureus.3353DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6255713PMC
September 2018
23 Reads

Temporal Bone Tumors: An Imaging Update.

Neuroimaging Clin N Am 2019 Feb;29(1):145-172

Department of Radiology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, 243 Charles Street, Boston, MA 02114, USA.

In their variety, temporal bone tumors mirror the complexity of the structure from which they arise. They include more familiar lesions, such as vestibular schwannomas and paragangliomas, and also rarer neoplasms, such as nonvestibular schwannomas, sarcomas, giant cell tumors, Schneiderian papillomas, and endolymphatic sac tumors. Diagnostic imaging is invaluable in evaluating such lesions because they are typically challenging to access surgically and monitor clinically. Read More

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http://dx.doi.org/10.1016/j.nic.2018.09.007DOI Listing
February 2019
23 Reads

Giant sellar metastasis from renal cell carcinoma: A case report and literature review.

Medicine (Baltimore) 2018 Nov;97(47):e13376

Department of Neurosurgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China.

Rationale: Sellar metastasis is a rare and complex disease whose clinical features are strongly associated with the primary malignancy. Here, we present a rare case of giant sellar metastasis spread from renal cell carcinoma (RCC).

Patient Concerns: A 30-year-old Chinese woman was admitted to our Hospital, reporting headache, nasal congestion, nausea, vomiting, and a sharp decline in her right eye vision. Read More

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http://dx.doi.org/10.1097/MD.0000000000013376DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6392949PMC
November 2018
19 Reads

Management of large-vessel vasculitis.

Curr Opin Rheumatol 2019 Jan;31(1):25-31

Department of Internal Medicine, Division of Rheumatology, School of Medicine, Istanbul University - Cerrahpasa, Istanbul, Turkey.

Purpose Of Review: Glucocorticoids are the mainstay of therapy for large-vessel vasculitis, but potential toxicity and frequent relapses led to studies with nonbiologic and biologic glucocorticoid-sparing agents. The aim of this review is to discuss the recent evidence for the management of giant cell arteritis (GCA) and Takayasu arteritis (TAK).

Recent Findings: Tocilizumab proved to be a powerful glucocorticoid-sparing agent for GCA in a randomized placebo-controlled trial, whereas the trials with tocilizumab and abatacept failed to show a significant difference from placebo in relapse-free survival rate in TAK. Read More

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http://dx.doi.org/10.1097/BOR.0000000000000561DOI Listing
January 2019
18 Reads

Pigmented villonodular synovitis does not influence the outcome following cementless total hip arthroplasty using ceramic-on-ceramic articulation: a case-control study with middle-term follow-up.

J Orthop Surg Res 2018 Nov 20;13(1):294. Epub 2018 Nov 20.

Department of Orthopaedic Surgery, General Hospital of People's Liberation Army, No.28 Fuxing Road, Haidian District, Beijing, 100853, China.

Background: Pigmented villonodular synovitis (PVNS) is a relatively rare, locally aggressive, and potentially recurrent synovial disease of large joints. The purpose of this study was to investigate (1) the disease recurrence rate and (2) the treatment outcomes including Harris hip scores, complications, and revision following cementless total hip arthroplasty (THA) with ceramic-on-ceramic (CoC) articulation in patients with PVNS.

Methods: Twenty-two patients (14 females and 8 males) with histologically confirmed PVNS underwent cementless THA using CoC bearings between 2000 and 2013. Read More

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http://dx.doi.org/10.1186/s13018-018-0996-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6245816PMC
November 2018
13 Reads

Perivascular epithelioid cell tumor outgrowth from the liver.

Int J Surg Case Rep 2018 10;53:295-298. Epub 2018 Nov 10.

Departments of Transplantation, Baskent University, Ankara, Turkey. Electronic address:

Introduction: Perivascular epithelioid celltumor (PEComa) is a rare mesenchymal neoplasia and can be found in various body sites. On the other hand, hepatic PEComa is very rare, with only a few studies having reported hepatic malignant PEComa. There is no gold standard regarding the use of diagnostic imaging studies. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22102612183047
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http://dx.doi.org/10.1016/j.ijscr.2018.10.046DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6240724PMC
November 2018
18 Reads

Osteoclast-like giant cell-rich carcinomas of the lung: a clinicopathological, immunohistochemical, and molecular study of 3 cases.

Hum Pathol 2019 Mar 14;85:168-173. Epub 2018 Nov 14.

Department of Pathology, the University of Texas, MD Anderson Cancer Center, Houston, TX 77030, USA. Electronic address:

Three cases of primary carcinomas of the lung each with an extensive osteoclast-like giant cell component are presented. The patients are 3 men between the ages of 58 and 67 years (average, 62.5 years) who presented with nonspecific symptoms. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00468177183042
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http://dx.doi.org/10.1016/j.humpath.2018.10.030DOI Listing
March 2019
13 Reads

A Triple-Classification Radiomics Model for the Differentiation of Primary Chordoma, Giant Cell Tumor, and Metastatic Tumor of Sacrum Based on T2-Weighted and Contrast-Enhanced T1-Weighted MRI.

J Magn Reson Imaging 2019 Mar 14;49(3):752-759. Epub 2018 Nov 14.

Department of Radiology, Peking University People's Hospital, Beijing, P. R. China.

Background: Preoperative differentiation between primary sacral chordoma (SC), sacral giant cell tumor (SGCT), and sacral metastatic tumor (SMT) is important for treatment decisions.

Purpose: To develop and validate a triple-classification radiomics model for the preoperative differentiation of SC, SGCT, and SMT based on T2-weighted fat saturation (T2w FS) and contrast-enhanced T1-weighted (CE T1w) MRI.

Study Type: Retrospective. Read More

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http://doi.wiley.com/10.1002/jmri.26238
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http://dx.doi.org/10.1002/jmri.26238DOI Listing
March 2019
9 Reads

Evaluation of a Novel General Pituitary Hormone Score to Evaluate the Function of the Residual Anterior Pituitary (Adenohypophysis) in Patients Following Surgery for Pituitary Adenoma.

Med Sci Monit 2018 Nov 6;24:7944-7951. Epub 2018 Nov 6.

Department of Neurosurgery, Fuzhou General Hospital, Fujian Medical University, Fuzhou, Fujian, China (mainland).

BACKGROUND The aim was to develop and assess a general pituitary hormone score to evaluate the function of the anterior pituitary (adenohypophysis) in patients following resection of pituitary adenomas. MATERIAL AND METHODS Sixty-six patients with pituitary null cell macroadenoma (1-3 cm diameter) (N=38) and pituitary null cell giant adenoma (≥3 cm diameter) (N=28) had preoperative and postoperative data including magnetic resonance imaging (MRI) and measurement of six pituitary hormones levels, adrenocorticotropic hormone (ACTH), growth hormone (GH), thyroid-stimulating hormone (TSH), prolactin (PRL), follicle-stimulating hormone (FSH), and luteinizing hormone (LH). The postoperative general pituitary hormone score, for 57 patients who underwent subtotal resection (>60%) and nine patients who underwent partial resection (≤60%), was 1-5 for each hormone level (score range, 6-30). Read More

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https://www.medscimonit.com/abstract/index/idArt/909925
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http://dx.doi.org/10.12659/MSM.909925DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6234753PMC
November 2018
7 Reads

Prognostic Significance of Preoperative Plasma D-Dimer Level and Clinical Factors in Patients with Spinal Giant Cell Tumor: Retrospective Analysis of 153 Patients in a Single Center.

World Neurosurg 2019 Feb 2;122:e872-e880. Epub 2018 Nov 2.

Department of Orthopedic Oncology, Changzheng Hospital, Second Military Medical University, Huangpu District, Shanghai, P.R. China. Electronic address:

Background: Giant cell tumor (GCT) of the spine is a benign tumor with local aggressiveness and potential for recurrence. No published study has discussed the prognostic role of preoperative D-dimer (D-D) level in spinal GCT. The purpose of this retrospective study was to evaluate the prognostic value of preoperative plasma D-D level and clinical factors. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18788750183246
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http://dx.doi.org/10.1016/j.wneu.2018.10.169DOI Listing
February 2019
11 Reads

Squamous cell carcinoma arising in a partially ruptured giant mature cystic teratoma: A case report.

Radiol Case Rep 2019 Jan 24;14(1):97-102. Epub 2018 Oct 24.

Cooper University Hospital, Department of Diagnostic Radiology, One Cooper Plaza, Camden, NJ 08103, USA.

Mature cystic teratomas are the most common ovarian germ cell tumors and represent 70% of the benign ovarian tumors occurring in women under age 30. In less than 2% of cases, these tumors can transform into malignancies. Squamous cell carcinoma arises most frequently from these tumors (in 80% of cases). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S19300433183041
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http://dx.doi.org/10.1016/j.radcr.2018.09.029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6204922PMC
January 2019
3 Reads

Long-term Follow-up of the Use of a Synthetic Bone Graft Composite in the Surgical Management of Primary Bone Tumors.

Orthopedics 2018 Nov 29;41(6):e868-e875. Epub 2018 Oct 29.

The surgical management of benign and benign aggressive bone tumors typically involves intralesional curettage and reconstruction of the resulting defect with cement or bone graft material. At the authors' institution, an injectable synthetic calcium sulfate-calcium phosphate composite is now the standard graft material for these cases. This study reports the long-term follow-up, specifically the stability of bone regeneration, for the use of the synthetic graft material for oncologic reconstruction. Read More

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https://www.healio.com/doiresolver?doi=10.3928/01477447-2018
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http://dx.doi.org/10.3928/01477447-20181023-03DOI Listing
November 2018
15 Reads

Arthroscopic Excision of Tendinous Giant Cell Tumors Causing Locking in the Knee Joint.

Acta Chir Orthop Traumatol Cech 2018 ;85(2):109-112

Istanbul Medipol University, Department of Orthopaedics and Traumatology, Istanbul, Turkey.

PURPOSE OF THE STUDY Non-osseous giant cell tumors are locally aggressive tumors arising around joints. They are commonly located around synovial joints such as wrist and knee and occasionally cause mechanical symptoms. MATERIAL AND METHODS This retrospective case series includes 7 patients operated due to intraarticular lesion. Read More

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January 2019
9 Reads

Large Multilocular Cystic Lesions in the Uterine Cervix: Differential Diagnosis and Significance.

J Med Ultrasound 2018 Jul-Sep;26(3):153-156. Epub 2018 May 7.

Department of Obstetrics and Gynecology, Faculty of Medicine, Alexandria University, Alexandria, Egypt.

Introduction: Cervical nabothian cysts are common in women of reproductive age. Although cysts are generally small and asymptomatic, large ones are extremely rare and may be misdiagnosed as malignancy.

Case Study: We report a case of large multiple complex nabothian cyst, which was suspected as malignant one on imaging and examination. Read More

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http://www.jmuonline.org/text.asp?2018/26/3/153/231989
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http://dx.doi.org/10.4103/JMU.JMU_38_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6159317PMC
May 2018
22 Reads

Comparison of radiomics machine-learning classifiers and feature selection for differentiation of sacral chordoma and sacral giant cell tumour based on 3D computed tomography features.

Eur Radiol 2019 Apr 2;29(4):1841-1847. Epub 2018 Oct 2.

Department of Radiology, Peking University People's Hospital, 11 Xizhimen Nandajie, Xicheng District, Beijing, 100044, People's Republic of China.

Objective: We aimed to identify optimal machine-learning methods for preoperative differentiation of sacral chordoma (SC) and sacral giant cell tumour (SGCT) based on 3D non-enhanced computed tomography (CT) and CT-enhanced (CTE) features.

Methods: A total of 95 patients were divided into a training set and a validation set. Three best feature selection methods (Relief, least absolute shrinkage and selection operator (LASSO) and Random Forest (RF)) and three classification methods, including generalised linear models (GLM), support vector machines (SVM) and RF, were compared for their performance in distinguishing SC and SGCT. Read More

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http://dx.doi.org/10.1007/s00330-018-5730-6DOI Listing
April 2019
4 Reads

Diagnosis of tuberous sclerosis complex in the fetus.

Eur J Paediatr Neurol 2018 Nov 12;22(6):1027-1034. Epub 2018 Sep 12.

1st Department of Pediatrics, Developmental Center "A. Fokas", Aristotle University of Thessaloniki, "Hippokratio" General Hospital, Thessaloniki, Greece. Electronic address:

Tuberous sclerosis complex is a dominantly inherited genetic disorder of striking clinical variability. It is caused by mutations in either TSC1 or TSC2 gene, which regulate cell growth and proliferation by inhibition of mTORC1 signaling. TS is characterized by the development of benign tumors in many tissues and organs and its neurological manifestations include epilepsy, autism, cognitive and behavioral dysfunction, and giant cell tumors. Read More

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http://dx.doi.org/10.1016/j.ejpn.2018.08.005DOI Listing
November 2018
12 Reads

[Histopathological classification principles of rheumatic joint diseases : Contribution of pathology to the diagnosis].

Orthopade 2018 Nov;47(11):939-946

Unfallchirurgische Klinik, Sektion obere Extremität, Fuß- und Rheumachirurgie, Medizinische Hochschule Hannover, Hannover, Deutschland.

Even though the diagnostics of rheumatic joint diseases are mostly based on clinical, immunoserological and imaging criteria, histopathology can also make a significant contribution. This is particularly true for clinically unclear monoarticular and periarticular diseases. The contribution of histopathology to the diagnosis of rheumatic diseases is manifold since the histopathological differential diagnosis includes the complete spectrum of synovial diseases. Read More

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http://dx.doi.org/10.1007/s00132-018-3649-xDOI Listing
November 2018
3 Reads

Assessment of denosumab treatment effects and imaging response in patients with giant cell tumor of bone.

World J Surg Oncol 2018 Sep 19;16(1):191. Epub 2018 Sep 19.

Amgen Inc., Thousand Oaks, CA, USA.

Background: Denosumab has been shown to reduce tumor size and progression, reform mineralized bone, and increase intralesional bone density in patients with giant cell tumor of bone (GCTB); however, radiologic assessment of tumors in bone is challenging. The study objective was to assess tumor response to denosumab using three different imaging parameters in a prespecified analysis in patients with GCTB from two phase 2 studies.

Methods: The studies enrolled adults and adolescents (skeletally mature and at least 12 years of age) with radiographically measurable GCTB that were given denosumab 120 mg every 4 weeks, with additional doses on days 8 and 15 of cycle 1. Read More

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http://dx.doi.org/10.1186/s12957-018-1478-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6146657PMC
September 2018
6 Reads

Central nervous system manifestations of tuberous sclerosis complex.

Am J Med Genet C Semin Med Genet 2018 Sep 19;178(3):291-298. Epub 2018 Sep 19.

Department of Neurosurgery, Baylor College of Medicine, Houston, Texas.

Tuberous sclerosis complex (TSC) is a neurocutaneous autosomal-dominant genetic syndrome marked by development of hamartomatous lesions arising from dysfunction of the mammalian target of rapamycin (mTOR) pathway. Although TSC remains a heterogeneous clinical entity, the recent inclusion of genetic diagnostic criteria reflects advancement in our understanding of its underlying etiopathogenesis. Abnormal cellular growth, differentiation, and migration result in multisystem sequelae, with neurologic manifestations of TSC representing the primary cause of morbidity and mortality for the majority of individuals. Read More

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http://dx.doi.org/10.1002/ajmg.c.31647DOI Listing
September 2018
3 Reads

Desmoplastic fibroblastoma mimicking tenosynovial giant cell tumor encasing a tendon of the foot.

Skeletal Radiol 2019 Apr 18;48(4):637-641. Epub 2018 Sep 18.

Department of Orthopaedic Surgery, CHA Bundang Medical Center, CHA University School of Medicine, 59, Yatap-ro, Bundang-gu, Seongnam-si, Gyeonggi-do, 13496, Republic of Korea.

Desmoplastic fibroblastoma is an uncommon, benign fibrous soft tissue tumor that usually occurs in the arms, shoulders, neck, hands, and feet in the fifth to seventh decades of life. In general, it is commonly located in the subcutaneous tissue and skeletal muscle. The authors report an unusual case of a desmoplastic fibroblastoma mimicking tenosynovial giant cell tumor encasing a tendon of the foot in a 72-year-old woman. Read More

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http://dx.doi.org/10.1007/s00256-018-3068-4DOI Listing
April 2019
2 Reads

Giant cell tumor of a rib following denosumab treatment.

Radiol Case Rep 2018 Oct 1;13(5):1018-1020. Epub 2018 Jun 1.

McGill University Health Centre, Department of Diagnostic Radiology, Montreal General Hospital, 1650 Cedar Avenue, Montreal, QC H3G 1A4, Canada.

Giant cell tumor (GCT) of the bone is an aggressive lytic lesion, commonly treated with surgery. Denosumab is a relatively recently introduced osteoclast activation inhibitor used for neoadjuvant therapy of GCT. Here we report the case of a GCT of a rib undergoing extensive osteosclerosis on computed tomography imaging following treatment with denosumab. Read More

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http://dx.doi.org/10.1016/j.radcr.2018.04.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6137337PMC
October 2018
1 Read

MRI assessment of the bone adjacent to giant cell tumours and its association with local recurrence after intralesional curettage.

Clin Radiol 2018 Nov 15;73(11):984.e19-984.e28. Epub 2018 Sep 15.

Department of Radiology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Electronic address:

Aim: To assess the tumour border surrounding giant cell tumour of the bone (GCTB) using magnetic resonance imaging (MRI) and investigate its association with local recurrence.

Materials And Methods: Sixty-nine GCTBs in proximal tibiae and distal femurs were studied. The pathological basis of the paintbrush border sign was explored. Read More

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http://dx.doi.org/10.1016/j.crad.2018.06.021DOI Listing
November 2018
3 Reads

The predictive value of preoperative neutrophil-lymphocyte ratio (NLR) on the recurrence of the local pigmented villonodular synovitis of the knee joint.

BMC Musculoskelet Disord 2018 Sep 19;19(1):339. Epub 2018 Sep 19.

Division of orthopaedic surgery, Huashan Hospital, Fudan University, Shanghai, 200040, China.

Background: To explore and evaluate the predictive value of preoperative Neutrophil-lymphocyte ratio (NLR) on the recurrence of pigmented villonodular synovitis (PVNS) of the knee joint treated by arthroscopic surgery combining local radiotherapy.

Methods: Sixty pathological-proven PVNS cases of the knee joint in our department from April 2006 to March 2017 were included. All of them are treated by arthroscopic synovectomy combined with adjuvant radiotherapy. Read More

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http://dx.doi.org/10.1186/s12891-018-2258-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6145334PMC
September 2018
12 Reads

[Visceral parasitic migration of liver: a clinicopathologic analysis of seven cases].

Zhonghua Bing Li Xue Za Zhi 2018 Sep;47(9):710-713

Department of Pathology, the Affiliated Drum Tower Hospital of Medical School of Nanjing University, Nanjing 210008, China.

To investigate the clinical, radiological and pathological features of visceral parasitic migration of the liver. Seven cases of visceral parasitic migration of liver were identified at the Affiliated Drum Tower Hospital of Medical School of Nanjing University from January 2008 to July 2017. Clinical data, enhanced CT image and pathological features were analyzed, combining with literature review. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0529-5807.2018.09.012DOI Listing
September 2018
2 Reads

Applications of PET/CT and PET/MR Imaging in Primary Bone Malignancies.

PET Clin 2018 Oct 17;13(4):623-634. Epub 2018 Aug 17.

Division of Nuclear Medicine, Department of Radiology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90007, USA.

Primary bone malignancies are characterized with anatomic imaging. However, in recent years, there has been an increased interest in PET/computed tomography scanning and PET/MRI with fludeoxyglucose F 18 for evaluating and staging musculoskeletal neoplasms. These hybrid imaging modalities have shown promise largely owing to their high sensitivity, ability to perform more thorough staging, and ability to monitor treatment response. Read More

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http://dx.doi.org/10.1016/j.cpet.2018.05.012DOI Listing
October 2018
20 Reads