2,796 results match your criteria Gianotti-Crosti Syndrome Papular Acrodermatitis of Childhood

Impact of Zinc Transport Mechanisms on Embryonic and Brain Development.

Nutrients 2022 Jun 17;14(12). Epub 2022 Jun 17.

Department of Pharmacology, Rutgers-Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA.

The trace element zinc (Zn) binds to over ten percent of proteins in eukaryotic cells. Zn flexible chemistry allows it to regulate the activity of hundreds of enzymes and influence scores of metabolic processes in cells throughout the body. Deficiency of Zn in humans has a profound effect on development and in adults later in life, particularly in the brain, where Zn deficiency is linked to several neurological disorders. Read More

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[Atypical involvement of purpuric syndrome caused by parvovirus B19. Case report in a 12-year-old female].

Rev Chilena Infectol 2022 02;39(1):95-99

Hospital Universitario Miguel Servet, Zaragoza, España.

Parvovirus B19 is the cause of a variety of exanthematous diseases during childhood and adolescence, such as erythema infectiosum and papular purpuric gloves and socks syndrome. This is an unusual, benign and acute acrodermatitis. Aphtous stomatitis, fever and other systemic symptoms can be associated with the eruption of the purpuric rash. Read More

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February 2022

Line-field confocal optical coherence tomography (LC-OCT) as a new tool for non-invasive differential diagnosis of pustular skin disorders.

J Eur Acad Dermatol Venereol 2022 Jun 13. Epub 2022 Jun 13.

Dermatology Unit and Skin Bank, Department of Medical, Surgical and Neurosciences, Siena University Hospital, Siena, Italy.

Background: The spectrum of pustular skin disorders (PSD) is large and particularly challenging, including inflammatory, infectious and amicrobial diseases. Moreover, although pustules represent the unifying clinical feature, they can be absent or not fully developed in the early stage of the disease. The line-field confocal optical coherence tomography (LC-OCT) is a recently developed imaging technique able to perform a non-invasive, in vivo, examination of the epidermis and upper dermis, reaching very high image resolution and virtual histology. Read More

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Secondary acrodermatitis enteropathica-like skin findings in a case of methylmalonic acidemia.

Pediatr Dermatol 2022 Jun 11. Epub 2022 Jun 11.

Department of Dermatology, West China Hospital, Sichuan University, Chengdu, China.

Methylmalonic acidemia (MMA) is an autosomal recessive genetic disorder caused by decreased activity of methylmalonyl-CoA mutase or metabolic disturbance of its coenzyme cobalamin, cutaneous manifestations are rare clinical signs in this disease. Herein, we describe a Chinese boy with MMA fed with a formula lacking branched-chain amino acids presenting with erythroderma and acrodermatitis enteropathica-like rash, a homozygous nonsense mutation c.742C>T (p. Read More

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Acroangiodermatitis presenting as unilateral hypertrophic verrucous plaques.

Dermatol Online J 2022 Mar 15;28(2). Epub 2022 Mar 15.

Department of Internal Medicine, UTHealth McGovern Medical School, Houston, Texas, USA.

Acroangiodermatitis (AAD)[KL1] is a rare vasoproliferative disorder often involving the extremities that has been classified into two variants. Mali-type AAD is more common and associated with chronic venous stasis. Stewart-Bluefarb syndrome[KL2], the other variant, is associated with underlying arteriovenous abnormalities. Read More

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Heterologous Expression of Full-Length and Truncated Human ZIP4 Zinc Transporter in .

Biomolecules 2022 May 21;12(5). Epub 2022 May 21.

Department of Chemistry and Biochemistry, Worcester Polytechnic Institute, Worcester, MA 01609, USA.

The human (h) transporter hZIP4 is the primary Zn importer in the intestine. hZIP4 is also expressed in a variety of organs such as the pancreas and brain. Dysfunction of hZIP4 can result in the Zn deficiency disease acrodermatitis enteropathica (AE). Read More

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[Viral exanthems in children].

Hautarzt 2022 Jun 25;73(6):452-460. Epub 2022 May 25.

Klinik für Dermatologie, Venerologie und Allergologie, Universitätsklinikum Schleswig-Holstein, Campus Kiel, Rosalind-Franklin-Str. 7, 24105, Kiel, Deutschland.

Viral and paraviral exanthems are the most common exanthems in children and are often the reason for a medical evaluation, especially in pediatric primary care and emergency rooms. Familiarity with the various eruptions is important for early diagnosis and patient management as well as minimizing the risk of infection. In this review, we present the newly described entities reactive infectious mucocutaneous eruptions (RIME) and the pediatric inflammatory multisystem syndrome (PIMS). Read More

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Acrodermatitis enteropathica-like eruption.

JAAD Case Rep 2022 Jun 25;24:20-23. Epub 2022 Mar 25.

Department of Dermatology, Mohammed V University in Rabat, Ibn Sina University Hospital, Rabat, Morocco.

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A case of acrodermatitis continua of Hallopeau successfully treated with guselkumab.

Dermatol Ther 2022 Apr 14:e15514. Epub 2022 Apr 14.

Dermatology Unit, Department of Mentals and Physical Health and Preventive Medicine, University of Campania Luigi Vanvitelli, Naples, Italy.

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Certolizumab Pegol: A New Therapeutic Approach for Acrodermatitis Continua of Hallopeau.

Skin Appendage Disord 2022 Mar 17;8(2):146-149. Epub 2021 Sep 17.

Dermatological Clinic, Department of Clinical and Molecular Sciences, Polytechnic University of the Marche Region, Ancona, Italy.

Introduction: Acrodermatitis continua of Hallopeau (ACH) is a rare, chronic, and recurrent form of pustular psoriasis (PP) localized to one or more digits. Due to the rarity of ACH, no clear treatment guidelines are currently available, making the therapeutic approach more complex.

Case Presentation: We report the first case of a young woman with ACH who was successfully treated with certolizumab pegol (CZP). Read More

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Acrodermatitis continua of Hallopeau: historical perspectives and modern management.

Ital J Dermatol Venerol 2022 Apr;157(2):132-136

Rutgers New Jersey Medical School, Unit of Dermatology, Newark, NJ, USA -

Acrodermatitis continua of Hallopeau is a sterile pustular dermatosis primarily of the digits. Often considered a type of pustular psoriasis, it may be difficult to diagnose and even more difficult to treat. Initial involvement of a distal finger or toe may appear as erythema which should not be confused with the chilblains-like findings potentially associated with COVID-19 infection. Read More

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Palmoplantar pustulosis and acrodermatitis continua of Hallopeau: demographic and clinical comparative study in a large multicentre cohort.

J Eur Acad Dermatol Venereol 2022 Apr 2. Epub 2022 Apr 2.

Dermatology Department, Hôpital Robert-Debré, Reims, France.

Background: Acral pustular disease within the pustular psoriasis/psoriasis-like spectrum mainly includes palmoplantar pustulosis (PPP) and acrodermatitis continua of Hallopeau (ACH). Scarce data argue for a distinction between these two entities, but no study has compared the clinical and epidemiologic characteristics of ACH and PPP.

Objectives: We aimed to perform a comparative description of the epidemiological and clinical characteristics of PPP and ACH in a multicentre retrospective cohort. Read More

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Transient Symptomatic Zinc Deficiency: An Overlooked Diagnosis in Acrodermatitis Enteropathica like Eruption in an Exclusively Breastfed Preterm Infant.

Oman Med J 2022 Mar 22;37(2):e364. Epub 2022 Mar 22.

Department of Pediatrics, Al-Kindy College of Medicine, University of Baghdad, Baghdad, Iraq.

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The Performance of Nine Commercial Serological Screening Assays for the Diagnosis of Lyme Borreliosis: a Multicenter Modified Two-Gate Design Study.

Microbiol Spectr 2022 04 17;10(2):e0051022. Epub 2022 Mar 17.

Centre for Infectious Disease Control, National Institute for Public Health and the Environmentgrid.31147.30 (RIVM), Bilthoven, the Netherlands.

In this retrospective study, the performance of nine serological screening assays for Lyme borreliosis (LB) diagnostics was evaluated using a study population of LB cases and controls. Sera derived from 74 well-defined LB cases and 122 controls were included. The LB cases were diagnosed with erythema migrans (EM;  = 11), Lyme neuroborreliosis (LNB;  = 35), Lyme arthritis (LA;  = 20), or acrodermatitis chronica atrophicans (ACA;  = 8). Read More

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Acrodermatitis continua of Hallopeau: Is apremilast an efficacious treatment option?

Dermatol Ther 2022 May 14;35(5):e15423. Epub 2022 Mar 14.

Section of Dermatology-Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy.

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Oral adverse events due to zinc deficiency after pancreaticoduodenectomy requiring continuous intravenous zinc supplementation: a case report and literature review.

BMC Oral Health 2022 03 3;22(1):52. Epub 2022 Mar 3.

Faculty of Dental Medicine, Oral Diagnosis and Medicine, Hokkaido University, Sapporo, Japan.

Background: Zinc is mainly absorbed in the duodenum and proximal jejunum, which are removed during pancreaticoduodenectomy (PD). Little is known about the adverse oral events and skin disorders caused by zinc deficiency after PD. Herein, we reviewed studies on the development of zinc deficiency after PD and reported about a patient with zinc deficiency after PD who required home intravenous zinc replacement. Read More

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Acrodermatitis continua of Hallopeau successfully treated with ixekizumab: A case report.

Dermatol Ther 2022 May 22;35(5):e15383. Epub 2022 Feb 22.

Section of Dermatology, Department of Clinical Medicine and Surgery, University of Naples, Naples, Italy.

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[Post-vaccination Gianotti-Crosti syndrome with unusual localization].

Therapie 2022 Jan 24. Epub 2022 Jan 24.

Centre national de pharmacovigilance, 1006 Tunis, Tunisie; Unité de recherche : UR17ES12, La Rabta, faculté de médecine, université Tunis- El-Manar, 1007 Tunis, Tunisie.

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January 2022

Case of Olmsted Syndrome with Essential Thrombocytosis Misdiagnosed as Acrodermatitis Enteropathica.

Indian J Dermatol 2021 Sep-Oct;66(5):574

Department of Pathology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.

Olmsted syndrome is a rare genodermatosis. Palmoplantar keratoderma and periorificial keratodermic plaques are the most important clinical findings. Additional findings associated with a large number of systems may accompany such as teeth, nail deformities, alopecia, mental retardation, and bone-joint anomalies. Read More

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January 2022

Clinico-Pathological and Dermoscopic Features in Acrodermatitis Continua of Hallopeau.

Indian J Dermatol 2021 Sep-Oct;66(5):543-544

Department of Dermatology, Venereology and Leprosy, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India E-mail:

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January 2022

A persistent plaque on the back of the hand.

Clin Exp Dermatol 2022 Apr 10;47(4):795-798. Epub 2022 Jan 10.

Dermatology, Imperial College Healthcare NHS Trust, London, UK.

We report the case of a 75-year-old woman presenting with acrodermatitis chronica atrophicans affecting the right hand dorsum, developing after an insect bite sustained in Greece. Diagnosis was confirmed by serology, PCR and histopathological findings. The plaque resolved following a 3-week course of oral doxycycline. Read More

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[Diagnosis of a rare and severe inflammatory bowel disease in an infant with peri-orificial ulcerations].

Ann Pathol 2021 Dec 31. Epub 2021 Dec 31.

Institut médicolégal de Marseille, hôpital de la Timone-Adultes, 264, rue Saint-Pierre, 13385 Marseille cedex 5, France.

We report the case of an infant aged 8 and a half months, who had an apparent life-threatening event and died despite optimal resuscitation management. The medical history was marked by mild symptoms, mainly feeding difficulties and progressively settling skin lesions. Parents were related (first cousins) and the patient had two healthy older sisters. Read More

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December 2021

Pustular psoriasis as an autoinflammatory keratinization disease (AiKD): Genetic predisposing factors and promising therapeutic targets.

Masashi Akiyama

J Dermatol Sci 2022 Jan 25;105(1):11-17. Epub 2021 Nov 25.

Department of Dermatology, Nagoya University Graduate School of Medicine, Nagoya, Japan. Electronic address:

Pustular psoriasis is a chronic inflammatory skin disease characterized by erythematous plaques with sterile pustules. It includes the distinct clinical entities generalized pustular psoriasis (GPP), acrodermatitis continua of Hallopeau (ACH) and palmoplantar pustular psoriasis (PPPP). Recently clarified pathomechanisms of pustular psoriasis indicate that hyperactivation of the skin innate immunity, including of the IL-1/IL-36 axis, plays an important role in the pathogenesis of pustular psoriasis. Read More

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January 2022

Diagnosis of Lyme Borreliosis With a Novel, Seminested Real-Time Polymerase Chain Reaction Targeting the 5S-23S Intergenic Spacer Region: Clinical Features, Histopathology, and Immunophenotype in 44 Patients.

Am J Dermatopathol 2022 May;44(5):338-347

Dermatologikum Hamburg, Hamburg, Germany; and.

Abstract: Lyme borreliosis (LB) is the most common tick-borne infection in Europe and North America. Polymerase chain reaction (PCR) is an important tool to confirm the diagnosis, but not always successful, especially when organisms are sparse. We developed a novel, seminested real-time PCR assay [target: 5S-23S intergenic spacer region (IGS)] and compared it with 3 well-established conventional PCR assays (IGS/OspA/real-time IGS) on 596 formalin-fixed, paraffin-embedded routine skin biopsies. Read More

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Pustular Psoriasis: From Pathophysiology to Treatment.

Biomedicines 2021 Nov 23;9(12). Epub 2021 Nov 23.

Dermatology Unit, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, 20122 Milan, Italy.

Pustular psoriasis (PP) is a clinicopathological entity encompassing different variants, i.e., acute generalized PP (GPP), PP of pregnancy (impetigo herpetiformis), annular (and circinate) PP, infantile/juvenile PP, palmoplantar PP/palmoplantar pustulosis, and acrodermatitis continua of Hallopeau (ACH), which have in common an eruption of superficial sterile pustules on an erythematous base. Read More

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November 2021

Zinc ionophores: chemistry and biological applications.

J Inorg Biochem 2022 03 9;228:111691. Epub 2021 Dec 9.

Dipartimento di Scienze Chimiche, Università degli Studi di Catania, v.le A. Doria 6, 95125 Catania, Italy. Electronic address:

Zinc can play a pathophysiological role in several diseases and can interfere in key processes of microbial growth. This evidence justifies the efforts in applying Zinc ionophores to restore Zinc homeostasis and treat bacterial/viral infections such as coronavirus diseases. Zinc ionophores increase the intracellular concentration of Zinc ions causing significant biological effects. Read More

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Severe de novo pustular psoriasiform immune-related adverse event associated with nivolumab treatment for metastatic esophageal adenocarcinoma.

J Cutan Pathol 2022 May 22;49(5):472-481. Epub 2021 Dec 22.

Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

Breakthrough targeted therapies have produced significant improvements in survival for cancer patients, but have a propensity to cause cutaneous immune-related adverse events (irAEs). Psoriasiform irAEs, representing about 4% of dermatologic toxicities associated with immune checkpoint inhibitor (ICI) therapy, are usually mild, occur in older patients and present as an exacerbation of existing psoriasis after several doses of ICI therapy. We report a case of a 58-year-old woman with metastatic esophageal adenocarcinoma and no prior history of psoriasis who developed a pustular psoriasiform irAE, beginning 3 days after initiation of nivolumab and progressing to confluent erythroderma with pustules over 2 weeks despite topical steroid use. Read More

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