Search our Database of Scientific Publications and Authors

I’m looking for a

    2524 results match your criteria Gianotti-Crosti Syndrome Papular Acrodermatitis of Childhood

    1 OF 51

    Cutaneous Lyme borreliosis: Guideline of the German Dermatology Society.
    Ger Med Sci 2017 5;15:Doc14. Epub 2017 Sep 5.
    Klinik für Infektiologie Klinik St Georg, Leipzig, Germany.
    This guideline of the German Dermatology Society primarily focuses on the diagnosis and treatment of cutaneous manifestations of Lyme borreliosis. It has received consensus from 22 German medical societies and 2 German patient organisations. It is the first part of an AWMF (Arbeitsgemeinschaft der Wissenschaftlichen Medizinischen Fachgesellschaften e. Read More

    The genetic basis for most patients with pustular skin disease remains elusive.
    Br J Dermatol 2017 Aug 5. Epub 2017 Aug 5.
    Institute of Human Genetics, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.
    Background: Rare variants in the genes IL36RN, CARD14 and AP1S3 have been identified to cause/ contribute to pustular skin diseases, primarily generalized pustular psoriasis (GPP).

    Objectives: To better understand the disease-relevance of these genes, we screened our cohorts of patients with pustular skin diseases (primarily GPP and palmoplantar pustular psoriasis [PPP]) for coding changes in these three genes. Carriers of single heterozygous IL36RN mutations were screened for a second mutation in IL36RN. Read More

    Diagnosis of acrodermatitis enteropathica in resource limited settings.
    BMJ Case Rep 2017 Aug 2;2017. Epub 2017 Aug 2.
    Department of Dermatology and Venereology, All India Institute of Medical Sciences, New Delhi, India.
    Acrodermatitis enteropathica (AE) is a rare inherited zinc deficiency that usually manifests in infancy within days in cases of bottlefed infants and days to weeks after weaning in breastfed infants. It is characterised by diarrhoea, dermatitis, alopecia and systemic symptoms. We report a case of acquired nutritional AE in a 6-month-old female infant who had diarrhoeal episodes and the characteristic dermatitis lesions in the acral and anogenital regions. Read More

    Characterization of zinc amino acid complexes for zinc delivery in vitro using Caco-2 cells and enterocytes from hiPSC.
    Biometals 2017 Jul 17. Epub 2017 Jul 17.
    WG Cellular Neurobiology and Neuro-Nanotechnology, Department of Biological Sciences, University of Limerick, Limerick, Ireland.
    Zn is essential for growth and development. The bioavailability of Zn is affected by several factors such as other food components. It is therefore of interest, to understand uptake mechanisms of Zn delivering compounds to identify ways to bypass the inhibitory effects of these factors. Read More

    Necrolytic Acral Erythema in Seronegative Hepatitis C.
    Case Rep Dermatol 2017 Jan-Apr;9(1):69-73. Epub 2017 Mar 17.
    Division of Dermatology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
    Necrolytic acral erythema (NAE) is a distinctive skin disorder. The exact cause and pathogenesis is still unclear. Most studies report an association of NAE with hepatitis C virus (HCV) infection. Read More

    [Analysis of SLC39A4 gene mutation in a patient with acrodermatitis enteropathica].
    Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2017 Jun;34(3):387-389
    Department of Dermatology, the Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan 637000, China.
    Objective: To detect pathogenic mutation of the SLC39A4 gene in a male patient with acrodermatitis enteropathica (AE).

    Methods: Peripheral venous blood sample and clinical data from the patient and his parents were collected. One hundred unrelated healthy individuals were recruited as controls. Read More

    European consensus statement on phenotypes of pustular psoriasis.
    J Eur Acad Dermatol Venereol 2017 Jun 6. Epub 2017 Jun 6.
    Division of Genetics and Molecular Medicine, King's College, London, UK.
    Pustular psoriasis (PP) is a group of inflammatory skin conditions characterized by infiltration of neutrophil granulocytes in the epidermis to such an extent that clinically visible sterile pustules develop. Because of clinical co-incidence, PP is currently grouped with psoriasis vulgaris (PV). However, PP and PV are phenotypically different, respond differently to treatments and seem to be distinct on the genetic level. Read More

    Short- and Long-Term Management of an Acute Pustular Psoriasis Flare: A Case Report.
    J Cutan Med Surg 2017 Sep/Oct;21(5):452-456. Epub 2017 May 23.
    2 Faculty of Medicine, University of Toronto, Toronto, ON, Canada.
    Background: Generalised pustular psoriasis (GPP) and acrodermatitis continua of Hallopeau (ACH) are chronic, relapsing variants of pustular psoriasis proven to be remarkably challenging to treat. Due to their uncommon presentation, there are few described cases in literature and scarce evidence for management. Further information is needed to help dermatologists formulate treatment plans for patients presenting with such diseases. Read More

    Adult autoimmune enteropathy presenting initially with acquired Acrodermatitis Enteropathica: a case report.
    BMC Dermatol 2017 May 18;17(1). Epub 2017 May 18.
    Department of Dermatology, Johns Hopkins University School of Medicine, 1550 Orleans Street, Koch CRB II, Unit 206, Baltimore, MD, 21231, USA.
    Background: Acrodermatitis enteropathica (AE) is a rare dermatitis secondary to zinc deficiency most commonly seen as an inherited disease in infants. In the last decade, increased number of reports have been published on the acquired form that presents in adulthood. Unlike its inherited counterpart, acquired AE (AAE) is often secondary to underlying pathologic or iatrogenic etiologies that interfere with nutritional absorption, such as inflammatory bowel disease or alcoholism. Read More

    A foot tumour as late cutaneous Lyme borreliosis: a new entity?
    Br J Dermatol 2017 May 6. Epub 2017 May 6.
    Dermatology Department, Nancy University Hospital, Vandoeuvre-les-Nancy, France.
    Acrodermatitis chronica atrophicans (ACA) is the late cutaneous form of Lyme borreliosis. The early inflammatory phase manifests with a bluish-red discoloration and doughy swelling of the skin. The atrophic phase represents a late-phase process with red discoloration, and a thin and wrinkled appearance of the skin. Read More

    Acrodermatitis enteropathica in a pair of twins.
    J Dermatol Case Rep 2016 Dec 31;10(4):65-67. Epub 2016 Dec 31.
    Department of Dermatology, College of Medicine, King Faisal University, Al-Ahsa, Saudi Arabia.
    Background: Acrodermatitis enteropathica (AE) is a rare autosomal recessive metabolic disorder. First described by Brandt in 1936 and was named by Danbolt. A mutation in the SLC39A4 gene on chromosome 8 q24. Read More

    Advances in pharmacotherapeutic management of common skin diseases in neonates and infants.
    Expert Opin Pharmacother 2017 May 21;18(7):717-725. Epub 2017 Apr 21.
    a Dermatology, Department of Experimental, Diagnostic and Specialty Medicine , Sant'Orsola-Malpighi Hospital, University of Bologna , Bologna , Italy.
    Introduction: neonatal and infantile skin diseases are frequently encountered in the clinical practice and represent worldwide a socioeconomic issue. They encompass a wide range of acquired or congenital conditions, including infections, vascular lesions and inflammatory diseases and can present with different degrees of severity, leading in some cases to dramatic complications. Areas covered: In this paper we report the most recent evidences on the management of some common skin diseases in neonates and infants. Read More

    Acquired Acrodermatitis Enteropathica Syndrome in a Kidney Transplant Receipt: A Case Report.
    Transplant Proc 2017 Apr;49(3):609-612
    Department of General Surgery, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.
    Acrodermatitis enteropathica syndrome (AE) is a clinical entity that results in severe zinc deficiency. It can be genetic or acquired. Acquired AE has been reported in patients with chronic liver disease, malabsorption syndrome, sickle cell anemia, and chronic renal failure. Read More

    Gianotti-Crosti syndrome: a case report of a teenager.
    An Bras Dermatol 2016 Sep-Oct;91(5 suppl 1):163-165
    Universidade do Estado do Rio de Janeiro (UERJ) - Rio de Janeiro (RJ), Brazil.
    Gianotti-Crosti syndrome is a rare disease characterized by acral papular eruption with symmetrical distribution. It is a benign and self-limited disease; the symptoms disappear after two to eight weeks, without recurrences or scars. Skin lesions are usually asymptomatic. Read More

    Depletion of Epidermal Langerhans Cells in the Skin Lesions of Pellagra Patients.
    Am J Dermatopathol 2017 Jun;39(6):428-432
    *Department of Dermatology, University of the Ryukyus, Okinawa, Japan; †Department of Dermatology, Tone-chuo Hospital, Numata, Japan; ‡Department of Dermatology, Gunma University, Maebashi, Japan; §Department of Dermatology, Wakayama Medical University, Wakayama, Japan; ¶Department of Dermatology, Nagasaki University, Nagasaki, Japan; and ‖Department of Dermatology, Saitama Medical University Saitama Medical Center, Kawagoe, Japan.
    Pellagra is a nutrient deficiency disease caused by insufficient niacin levels. Recent studies have shown that numbers of epidermal Langerhans cells decreased in other diseases caused by nutritional deficiencies, including necrolytic migratory erythema and acrodermatitis enteropathica. Epidermal Langerhans cells are capable of modulating or even halting the inflammatory reaction. Read More

    Perianal Lesions in Children: An Updated Review.
    Am J Clin Dermatol 2017 Jun;18(3):343-354
    Department of Dermatology, State University of New York Downstate Medical Center, 10 West, 800 Poly Place, Brooklyn, NY, 11203, USA.
    Perianal lesions in children are common reasons for dermatology clinic visits and a well-defined approach to diagnosis and management is helpful to the practicing clinician. In this article, we review and update various etiologies of perianal lesions in the pediatric population, including infectious, papulosquamous, vascular, and neoplastic. We provide a standard initial approach to diagnosis and updates on current management. Read More

    [Cutaneous manifestations of Lyme disease : Pitfalls in the serological diagnostic workup].
    Hautarzt 2017 Apr;68(4):329-339
    Abteilung für Dermatologie, Landesklinikum Wiener Neustadt, Wiener Neustadt, Österreich.
    Serology, the detection of B. burgdorferi-specific IgM and IgG serum antibodies, is the most common laboratory test to diagnose cutaneous manifestations of Lyme disease. In a two-tiered approach, an ELISA is used as a screening test. Read More

    Chronic Lyme borreliosis associated with minimal change glomerular disease: a case report.
    BMC Nephrol 2017 Feb 6;18(1):51. Epub 2017 Feb 6.
    Department of Nephrology, Dialysis and Hypertension, Edouard Herriot Hospital, Hospices Civils de Lyon, 5 Place d'Arsonval, 69437, Lyon, Cedex 03, France.
    Background: There are only few cases of renal pathology induced by Lyme borreliosis in the literature, as this damage is rare and uncommon in humans. This patient is the first case of minimal change glomerular disease associated with chronic Lyme borreliosis.

    Case Presentation: A 65-year-old Caucasian woman was admitted for an acute edematous syndrome related to a nephrotic syndrome. Read More

    Ustekinumab for the treatment of acrodermatitis continua of Hallopeau refractory to anti-TNF agents.
    Dermatol Ther 2017 Mar 30;30(2). Epub 2017 Jan 30.
    Department of Dermatology, Gazi University Faculty of Medicine, Ankara, Turkey.
    Acrodermatitis continua of Hallopeau (ACH) is a variant of pustular psoriasis that is often very difficult to treat. Almost all anti-psoriatic agents have been used in the treatment of ACH. Ustekinumab, a fully human monoclonal antibody of the IgG1 class, is directed to the shared p40 subunit of cytokines IL-12 and IL-23. Read More

    Enzootic origins for clinical manifestations of Lyme borreliosis.
    Infect Genet Evol 2017 Apr 28;49:48-54. Epub 2016 Dec 28.
    Laboratory for Zoonoses and Environmental Microbiology, National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands. Electronic address:
    Both early localized and late disseminated forms of Lyme borreliosis are caused by Borrelia burgdorferi senso lato. Differentiating between the spirochetes that only cause localized skin infection from those that cause disseminated infection, and tracing the group of medically-important spirochetes to a specific vertebrate host species, are two critical issues in disease risk assessment and management. Borrelia burgdorferi senso lato isolates from Lyme borreliosis cases with distinct clinical manifestations (erythema migrans, neuroborreliosis, acrodermatitis chronica atrophicans, and Lyme arthritis) and isolates from Ixodes ricinus ticks feeding on rodents, birds and hedgehogs were typed to the genospecies level by sequencing part of the intergenic spacer region. Read More

    Pathogenetic implications of the age at time of diagnosis and skin location for acrodermatitis chronica atrophicans.
    Ticks Tick Borne Dis 2017 Feb 24;8(2):266-269. Epub 2016 Nov 24.
    Department of Infectious Diseases, University Medical Centre Ljubljana, Ljubljana, Slovenia. Electronic address:
    Background: The pathogenesis of acrodermatitis chronica atrophicans (ACA) is not well understood.

    Objective: The purpose of this study was to gain a better understanding of ACA by utilizing a large data set of adult Slovenian patients with Lyme borreliosis.

    Methods: The age of 590 ACA patients was compared with that of patients with other manifestations of Lyme borreliosis. Read More

    Lyme borreliosis.
    Nat Rev Dis Primers 2016 12 15;2:16090. Epub 2016 Dec 15.
    Bacterial Diseases Branch, Division of Vector-Borne Diseases, Centers for Disease Control and Prevention, Fort Collins, Colorado, USA.
    Lyme borreliosis is a tick-borne disease that predominantly occurs in temperate regions of the northern hemisphere and is primarily caused by the bacterium Borrelia burgdorferi in North America and Borrelia afzelii or Borrelia garinii in Europe and Asia. Infection usually begins with an expanding skin lesion, known as erythema migrans (referred to as stage 1), which, if untreated, can be followed by early disseminated infection, particularly neurological abnormalities (stage 2), and by late infection, especially arthritis in North America or acrodermatitis chronica atrophicans in Europe (stage 3). However, the disease can present with any of these manifestations. Read More

    A case-control study on the association of pulse oral poliomyelitis vaccination and Gianotti-Crosti syndrome.
    Int J Dermatol 2017 Jan;56(1):75-79
    JC School of Public Health and Primary Care, The Chinese University of Hong Kong and Prince of Wales Hospital, Hong Kong.
    Background: Since 1995, the Indian government has been launching two National Immunization Days (NIDs) annually to administer oral polio vaccines (OPVs) to children under the age of 5. Our aim was to investigate the association between OPVs and Gianotti-Crosti syndrome (GCS).

    Methods: A board-certified dermatologist in solo practice conducted the examinations. Read More

    An Acrodermatitis Enteropathica-Associated Zn Transporter, ZIP4, Regulates Human Epidermal Homeostasis.
    J Invest Dermatol 2017 Apr 7;137(4):874-883. Epub 2016 Dec 7.
    Basic Research & Innovation Division, R&D Unit, AmorePacific Corporation, Yongin, Republic of Korea. Electronic address:
    Acrodermatitis enteropathica is an autosomal recessive disorder characterized by scaly eczematous dermatosis accompanied by alopecia and diarrhea. Various mutations in the SLC39A4 gene (ZIP4), which encodes a zinc transporter, are responsible for this disorder. However, the molecular mechanism underlying the involvement of ZIP4 in the pathogenesis of this condition has yet to be established. Read More

    Acrodermatitis caused by nutritional deficiency and metabolic disorders.
    Clin Dermatol 2017 Jan - Feb;35(1):64-67. Epub 2016 Sep 10.
    Department of Dermatology, University of Connecticut Health Center, Farmington, CT. Electronic address:
    Both the metabolism and dietary intake of vitamins and minerals are essential to homeostatic function in the body. Dietary excess or deficiency, as well as genetic and acquired disorders in metabolism, can present dermatologically and systemically. More specifically, disorders in metabolism of zinc, biotin, essential fatty acids, and vitamin B, can appear with acrally distributed dermatoses. Read More

    Acral manifestations of systemic diseases: Drug-induced and infectious diseases.
    Clin Dermatol 2017 Jan - Feb;35(1):55-63. Epub 2016 Sep 10.
    Department of Dermatology, Second University of Naples, Naples, Italy.
    Drug reactions and systemic diseases often involve the skin. In particular, most drug-induced reactions and many infectious diseases present with dermatologic manifestations localized acrally, that is on distal portions of limbs (hand, foot) and head (ears, nose). A detailed review of all acral dermatologic signs of drug reactions and systemic diseases is beyond the scope of this paper, although some of these disorders will be discussed specifically here. Read More

    Progress in the molecular diagnosis of Lyme disease.
    Expert Rev Mol Diagn 2017 Jan 28;17(1):19-30. Epub 2016 Nov 28.
    a Institute of Microbiology ansd Immunology, Faculty of Medicine , University of Ljubljana , Ljubljana , Slovenia.
    Introduction: Current laboratory testing of Lyme borreliosis mostly relies on serological methods with known limitations. Diagnostic modalities enabling direct detection of pathogen at the onset of the clinical signs could overcome some of the limitations. Molecular methods detecting borrelial DNA seem to be the ideal solution, although there are some aspects that need to be considered. Read More

    AcroangiodermatitisA Presentation of Two Cases of Nonhealing Ulcerations in the Lower Extremity.
    J Am Podiatr Med Assoc 2016 Sep;106(5):364-369
    Acroangiodermatitis (AAD), also known as pseudo-Kaposi's sarcoma, is an uncommon benign angioproliferative condition most commonly seen in the lower extremities. This condition often presents as discolored patches that progress to painful ulcerations. The list of vascular conditions associated with this diagnosis is vast. Read More

    Secondary acrodermatitis enteropathica-like lesions in a child with newly diagnosed coeliac disease.
    Paediatr Int Child Health 2016 Feb 26;36(1):72-5. Epub 2014 Dec 26.
    Department of Paediatrics, SCB Medical College , Cuttack.
    Zinc deficiency in patients with coeliac disease (CD) may result either from cumulative loss of insoluble zinc complexes or impaired zinc absorption because of damaged intestinal epithelial cell membrane. Zinc deficiency in CD is mild to moderate, though severe deficiency can occur in refractory or chronic CD cases with poor response to gluten-free diet (GFD). A boy aged 19 months presented with persistent diarrhoea, was diagnosed with CD, and developed severe zinc deficiency with acrodermatitis enteropathica-like disease while on GFD and zinc supplementation. Read More

    Homogeneous Inflammatory Gene Profiles Induced in Human Dermal Fibroblasts in Response to the Three Main Species of Borrelia burgdorferi sensu lato.
    PLoS One 2016 5;11(10):e0164117. Epub 2016 Oct 5.
    EA7290 Early Bacterial Virulence: Lyme borreliosis Group, FMTS, Université de Strasbourg, Strasbourg, France.
    In Lyme borreliosis, the skin is the key site for bacterial inoculation by the infected tick and for cutaneous manifestations. We previously showed that different strains of Borrelia burgdorferi sensu stricto isolated from tick and from different clinical stages of the Lyme borreliosis (erythema migrans, and acrodermatitis chronica atrophicans) elicited a very similar transcriptional response in normal human dermal fibroblasts. In this study, using whole transcriptome microarray chips, we aimed to compare the transcriptional response of normal human dermal fibroblasts stimulated by 3 Borrelia burgdorferi sensu lato strains belonging to 3 main pathogenic species (B. Read More

    Speckled variance optical coherence tomography for the assessment of nail involvement in acrodermatitis continua of Hallopeau: A case study.
    J Int Med Res 2016 Sep;44(1 suppl):119-123
    Department of Dermatology, University of Modena and Reggio Emilia, Modena, Italy.
    Noninvasive techniques for nail imaging would be useful for confirming diagnosis and monitoring treatment response at the microscopic level in patients with nail psoriasis. However, the use of ultrasound and high-resolution magnetic resonance imaging in nail evaluation is limited. Optical coherence tomography (OCT) produces high-resolution images of transversal tissue sections and represents an optimal approach to the study of the nail. Read More

    Itch Management in Childhood.
    Curr Probl Dermatol 2016 23;50:173-91. Epub 2016 Aug 23.
    Klinik für Dermatologie, Venerologie und Allergologie, Universitätsklinikum Schleswig-Holstein, Kiel, Germany.
    Itch in children is a very common symptom and is mainly related to a skin disease rather than an underlying systemic disorder. The most common dermatoses include atopic dermatitis, contact dermatitis, insect bites, scabies, and pediculosis capitis. There are specific diagnostic patterns which require the evaluation of a careful history and dermatological examination. Read More

    Isoleucine Deficiency in a Neonate Treated for Maple Syrup Urine Disease Masquerading as Acrodermatitis Enteropathica.
    Indian Pediatr 2016 Aug;53(8):738-40
    Departments of Neonatology, *Pediatrics and #Clinical Genetics Unit,Christian Medical College, Vellore, Tamilnadu, India. Correspondence to: Dr Benjamin Ross, Department of Neonatology, Christian Medical College, Vellore 632 004, Tamilnadu, India.
    Background: Special diet with restricted branched-chain-amino-acids used for treating maple syrup urine disease can lead to specific amino acid deficiencies.

    Case Characteristics: We report a neonate who developed skin lesions due to isoleucine deficiency while using specialised formula.

    Intervention/outcome: Feeds were supplemented with expressed breast milk. Read More

    Antibody profile to Borrelia burgdorferi in veterinarians from Nuevo León, Mexico, a non-endemic area of this zoonosis.
    Reumatologia 2016 18;54(3):97-102. Epub 2016 Jul 18.
    Universidad Autonóma de Nuevo León, School of Biological Sciences, Institute of Biotechnology, Nuevo León, Mexico; Rheumatology Unit, Medical Faculty and University Hospital Dr. José Eleuterio González, Nuevo León, Mexico.
    Objectives: Lyme disease is a tick-borne disease caused by infections with Borrelia. Persons infected with Borrelia can be asymptomatic or can develop disseminated disease. Diagnosis and recognition of groups at risk of infection with Borrelia burgdorferi is of great interest to contemporary rheumatology. Read More

    1 OF 51