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    2490 results match your criteria Gianotti-Crosti Syndrome Papular Acrodermatitis of Childhood

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    Chronic Lyme borreliosis associated with minimal change glomerular disease: a case report.
    BMC Nephrol 2017 Feb 6;18(1):51. Epub 2017 Feb 6.
    Department of Nephrology, Dialysis and Hypertension, Edouard Herriot Hospital, Hospices Civils de Lyon, 5 Place d'Arsonval, 69437, Lyon, Cedex 03, France.
    Background: There are only few cases of renal pathology induced by Lyme borreliosis in the literature, as this damage is rare and uncommon in humans. This patient is the first case of minimal change glomerular disease associated with chronic Lyme borreliosis.

    Case Presentation: A 65-year-old Caucasian woman was admitted for an acute edematous syndrome related to a nephrotic syndrome. Read More

    Ustekinumab for the treatment of acrodermatitis continua of Hallopeau refractory to anti-TNF agents.
    Dermatol Ther 2017 Jan 30. Epub 2017 Jan 30.
    Department of Dermatology, Gazi University Faculty of Medicine, Ankara, Turkey.
    Acrodermatitis continua of Hallopeau (ACH) is a variant of pustular psoriasis that is often very difficult to treat. Almost all anti-psoriatic agents have been used in the treatment of ACH. Ustekinumab, a fully human monoclonal antibody of the IgG1 class, is directed to the shared p40 subunit of cytokines IL-12 and IL-23. Read More

    Enzootic origins for clinical manifestations of Lyme borreliosis.
    Infect Genet Evol 2016 Dec 28;49:48-54. Epub 2016 Dec 28.
    Laboratory for Zoonoses and Environmental Microbiology, National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands. Electronic address:
    Both early localized and late disseminated forms of Lyme borreliosis are caused by Borrelia burgdorferi senso lato. Differentiating between the spirochetes that only cause localized skin infection from those that cause disseminated infection, and tracing the group of medically-important spirochetes to a specific vertebrate host species, are two critical issues in disease risk assessment and management. Borrelia burgdorferi senso lato isolates from Lyme borreliosis cases with distinct clinical manifestations (erythema migrans, neuroborreliosis, acrodermatitis chronica atrophicans, and Lyme arthritis) and isolates from Ixodes ricinus ticks feeding on rodents, birds and hedgehogs were typed to the genospecies level by sequencing part of the intergenic spacer region. Read More

    Pathogenetic implications of the age at time of diagnosis and skin location for acrodermatitis chronica atrophicans.
    Ticks Tick Borne Dis 2017 Feb 24;8(2):266-269. Epub 2016 Nov 24.
    Department of Infectious Diseases, University Medical Centre Ljubljana, Ljubljana, Slovenia. Electronic address:
    Background: The pathogenesis of acrodermatitis chronica atrophicans (ACA) is not well understood.

    Objective: The purpose of this study was to gain a better understanding of ACA by utilizing a large data set of adult Slovenian patients with Lyme borreliosis.

    Methods: The age of 590 ACA patients was compared with that of patients with other manifestations of Lyme borreliosis. Read More

    Lyme borreliosis.
    Nat Rev Dis Primers 2016 12 15;2:16090. Epub 2016 Dec 15.
    Bacterial Diseases Branch, Division of Vector-Borne Diseases, Centers for Disease Control and Prevention, Fort Collins, Colorado, USA.
    Lyme borreliosis is a tick-borne disease that predominantly occurs in temperate regions of the northern hemisphere and is primarily caused by the bacterium Borrelia burgdorferi in North America and Borrelia afzelii or Borrelia garinii in Europe and Asia. Infection usually begins with an expanding skin lesion, known as erythema migrans (referred to as stage 1), which, if untreated, can be followed by early disseminated infection, particularly neurological abnormalities (stage 2), and by late infection, especially arthritis in North America or acrodermatitis chronica atrophicans in Europe (stage 3). However, the disease can present with any of these manifestations. Read More

    An acrodermatitis enteropathica-associated Zn transporter, ZIP4, regulates human epidermal homeostasis.
    J Invest Dermatol 2016 Dec 7. Epub 2016 Dec 7.
    Basic Research & Innovation Division, R&D Unit, AmorePacific Corporation, Yongin, Republic of Korea. Electronic address:
    Acrodermatitis enteropathica (AE) is an autosomal recessive disorder that is characterized by scaly eczematous dermatosis accompanied by alopecia and diarrhea. Various mutations in the SLC39A4 gene (ZIP4), which encodes a zinc transporter, are responsible for this disorder. However, the molecular mechanism underlying the involvement of ZIP4 in the pathogenesis of this condition has yet to be established. Read More

    Acrodermatitis caused by nutritional deficiency and metabolic disorders.
    Clin Dermatol 2017 Jan - Feb;35(1):64-67. Epub 2016 Sep 10.
    Department of Dermatology, University of Connecticut Health Center, Farmington, CT. Electronic address:
    Both the metabolism and dietary intake of vitamins and minerals are essential to homeostatic function in the body. Dietary excess or deficiency, as well as genetic and acquired disorders in metabolism, can present dermatologically and systemically. More specifically, disorders in metabolism of zinc, biotin, essential fatty acids, and vitamin B, can appear with acrally distributed dermatoses. Read More

    Progress in the molecular diagnosis of Lyme disease.
    Expert Rev Mol Diagn 2017 Jan 28;17(1):19-30. Epub 2016 Nov 28.
    a Institute of Microbiology ansd Immunology, Faculty of Medicine , University of Ljubljana , Ljubljana , Slovenia.
    Introduction: Current laboratory testing of Lyme borreliosis mostly relies on serological methods with known limitations. Diagnostic modalities enabling direct detection of pathogen at the onset of the clinical signs could overcome some of the limitations. Molecular methods detecting borrelial DNA seem to be the ideal solution, although there are some aspects that need to be considered. Read More

    Secondary acrodermatitis enteropathica-like lesions in a child with newly diagnosed coeliac disease.
    Paediatr Int Child Health 2016 Feb 26;36(1):72-5. Epub 2014 Dec 26.
    Department of Paediatrics, SCB Medical College , Cuttack.
    Zinc deficiency in patients with coeliac disease (CD) may result either from cumulative loss of insoluble zinc complexes or impaired zinc absorption because of damaged intestinal epithelial cell membrane. Zinc deficiency in CD is mild to moderate, though severe deficiency can occur in refractory or chronic CD cases with poor response to gluten-free diet (GFD). A boy aged 19 months presented with persistent diarrhoea, was diagnosed with CD, and developed severe zinc deficiency with acrodermatitis enteropathica-like disease while on GFD and zinc supplementation. Read More

    Homogeneous Inflammatory Gene Profiles Induced in Human Dermal Fibroblasts in Response to the Three Main Species of Borrelia burgdorferi sensu lato.
    PLoS One 2016 5;11(10):e0164117. Epub 2016 Oct 5.
    EA7290 Early Bacterial Virulence: Lyme borreliosis Group, FMTS, Université de Strasbourg, Strasbourg, France.
    In Lyme borreliosis, the skin is the key site for bacterial inoculation by the infected tick and for cutaneous manifestations. We previously showed that different strains of Borrelia burgdorferi sensu stricto isolated from tick and from different clinical stages of the Lyme borreliosis (erythema migrans, and acrodermatitis chronica atrophicans) elicited a very similar transcriptional response in normal human dermal fibroblasts. In this study, using whole transcriptome microarray chips, we aimed to compare the transcriptional response of normal human dermal fibroblasts stimulated by 3 Borrelia burgdorferi sensu lato strains belonging to 3 main pathogenic species (B. Read More

    Speckled variance optical coherence tomography for the assessment of nail involvement in acrodermatitis continua of Hallopeau: A case study.
    J Int Med Res 2016 Sep;44(1 suppl):119-123
    Department of Dermatology, University of Modena and Reggio Emilia, Modena, Italy.
    Noninvasive techniques for nail imaging would be useful for confirming diagnosis and monitoring treatment response at the microscopic level in patients with nail psoriasis. However, the use of ultrasound and high-resolution magnetic resonance imaging in nail evaluation is limited. Optical coherence tomography (OCT) produces high-resolution images of transversal tissue sections and represents an optimal approach to the study of the nail. Read More

    Isoleucine Deficiency in a Neonate Treated for Maple Syrup Urine Disease Masquerading as Acrodermatitis Enteropathica.
    Indian Pediatr 2016 Aug;53(8):738-40
    Departments of Neonatology, *Pediatrics and #Clinical Genetics Unit,Christian Medical College, Vellore, Tamilnadu, India. Correspondence to: Dr Benjamin Ross, Department of Neonatology, Christian Medical College, Vellore 632 004, Tamilnadu, India.
    Background: Special diet with restricted branched-chain-amino-acids used for treating maple syrup urine disease can lead to specific amino acid deficiencies.

    Case Characteristics: We report a neonate who developed skin lesions due to isoleucine deficiency while using specialised formula.

    Intervention/outcome: Feeds were supplemented with expressed breast milk. Read More

    Antibody profile to Borrelia burgdorferi in veterinarians from Nuevo León, Mexico, a non-endemic area of this zoonosis.
    Reumatologia 2016 18;54(3):97-102. Epub 2016 Jul 18.
    Universidad Autonóma de Nuevo León, School of Biological Sciences, Institute of Biotechnology, Nuevo León, Mexico; Rheumatology Unit, Medical Faculty and University Hospital Dr. José Eleuterio González, Nuevo León, Mexico.
    Objectives: Lyme disease is a tick-borne disease caused by infections with Borrelia. Persons infected with Borrelia can be asymptomatic or can develop disseminated disease. Diagnosis and recognition of groups at risk of infection with Borrelia burgdorferi is of great interest to contemporary rheumatology. Read More

    A Souvenir From France: Acrodermatitis Chronica Atrophicans Presenting in the United States.
    Skinmed 2016 1;14(3):217-9. Epub 2016 Jun 1.
    Department of Dermatology, Robert Wood Johnson Medical School, Rutgers University, New Brunswick, NJ;
    A 70-year-old man was referred by his rheumatologist to our dermatology clinic for evaluation of dermatitis on his right arm that appeared 3 months earlier. The skin lesion was asymptomatic and the patient denied current systemic symptoms, including fever, chills, and joint pain; however, 10 months prior to this presentation he experienced arthritis in the left knee. At that time, Borrelia serology revealed positive IgG (6. Read More

    [Improvement in zinc nutrition due to zinc transporter-targeting strategy].
    Nihon Rinsho 2016 Jul;74(7):1234-8
    Adequate intake of zinc from the daily diet is indispensable to maintain health. However, the dietary zinc content often fails to fulfill the recommended daily intake, leading to zinc deficiency and also increases the risk of developing chronic diseases, particularly in elderly individuals. Therefore, increased attention is required to overcome zinc deficiency and it is important to improve zinc nutrition in daily life. Read More

    [The functional role of zinc in skin diseases].
    Nihon Rinsho 2016 Jul;74(7):1144-9
    Abstract Acrodermatitis enteropathica(AE) is caused by inherited or acquired zinc deficiency. Cutaneous clinical manifestations observed in AE include characteristic dermatitis on acral, periorificial and anogenital areas through an unknown mechanism. Recently, we found that mice fed a zinc-deficient diet develop a severe irritant contact dermatitis that has the histological features of the skin inflammation seen in AE patients. Read More

    Acrodermatitis dysmetabolica in an infant with maple syrup urine disease.
    Clin Exp Dermatol 2016 Aug 23;41(6):651-4. Epub 2016 Jun 23.
    Department of Dermatology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
    Acrodermatitis dysmetabolica (AD) is a rare, newly termed, and poorly understood disease that appears to be clinically similar to acrodermatitis enteropathica (AE). Both diseases are characterized by the triad of periorificial and acral dermatitis, diarrhoea, and alopecia. Unlike AE, which is caused by zinc deficiency, AD is caused by numerous metabolic disorders. Read More

    Zinc and skin biology.
    Arch Biochem Biophys 2016 Dec 7;611:113-119. Epub 2016 Jun 7.
    Department of Dermatology, Faculty of Medicine, University of Yamanashi, Yamanashi, 409-3898, Japan.
    Of all tissues, the skin has the third highest abundance of zinc in the body. In the skin, the zinc concentration is higher in the epidermis than in the dermis, owing to a zinc requirement for the active proliferation and differentiation of epidermal keratinocytes. Here we review the dynamics and functions of zinc in the skin as well as skin disorders associated with zinc deficiency, zinc finger domain-containing proteins, and zinc transporters. Read More

    [Pustular psoriasis].
    Hautarzt 2016 Jun;67(6):445-53
    Klinik für Dermatologie, Venerologie und Allergologie, Universitätsmedizin Göttingen, Robert-Koch-Str. 40, UMG, 37075, Göttingen, Deutschland.
    A number of pustular skin diseases share clinical, pathogenetic, and epidemiological aspects with plaque-type psoriasis, and their classification as a separate clinical entity or as a subtype of psoriasis remains controversial, which is also reflected in the multitude of their names. They include generalized pustular psoriasis with its subtypes, acrodermatitis continua suppurativa (Hallopeau), acute pustulosis palmopantaris, palmoplantar pustular psoriasis, and pustular variants of a mostly TNF-blocker triggered paradoxical psoriasiform dermatitis. In this article, the epidemiology, clinical picture, pathogenesis, genetics, and therapy of these pustular skin diseases are described. Read More

    IL36RN Mutations Affect Protein Expression and Function: A Basis for Genotype-Phenotype Correlation in Pustular Diseases.
    J Invest Dermatol 2016 Sep 21;136(9):1811-9. Epub 2016 May 21.
    INSERM unit U1163, Imagine Institute, Necker-Enfants Malades Hospital, Paris, France. Electronic address:
    Homozygous or compound heterozygous IL36RN gene mutations underlie the pathogenesis of psoriasis-related pustular eruptions including generalized pustular psoriasis, palmoplantar pustular psoriasis, acrodermatitis continua of Hallopeau, and acute generalized exanthematous pustular eruption. We identified two unreported IL36RN homozygous mutations (c.41C>A/p. Read More

    Acrodermatitis Enteropathica: A Case Report.
    Medicine (Baltimore) 2016 May;95(20):e3553
    From the Pediatrics Department (NN, O-EF, VVL, AI, VS), "Gr. T. Popa" University of Medicine and Pharmacy; and "St Mary" Children Emergency Hospital (LC), Iasi, Romania.
    Acrodermatitis enteropathica is a rare genetic autosomal recessive disorder, characterized by periorificial dermatitis, alopecia, and diarrhea. It is caused by mutations in the gene that encodes a membrane protein that binds zinc. We report a 14-month-old boy, admitted for erythematous, scaly and pustular lesions, initially located in the inguinal and perianal regions and on thighs, and very few erythematous lesions on the face. Read More

    Imbalanced presence of Borrelia burgdorferi s.l. multilocus sequence types in clinical manifestations of Lyme borreliosis.
    Infect Genet Evol 2016 Aug 25;42:66-76. Epub 2016 Apr 25.
    Laboratory for Zoonoses and Environmental Microbiology, National Institute for Public Health and Environment (RIVM), Bilthoven, The Netherlands.
    In this study we used typing based on the eight multilocus sequence typing scheme housekeeping genes (MLST) and 5S-23S rDNA intergenic spacer (IGS) to explore the population structure of Borrelia burgdorferi sensu lato isolates from patients with Lyme borreliosis (LB) and to test the association between the B. burgdorferi s.l. Read More

    Pityriasis Rosea, Gianotti-Crosti Syndrome, Asymmetric Periflexural Exanthem, Papular-Purpuric Gloves and Socks Syndrome, Eruptive Pseudoangiomatosis, and Eruptive Hypomelanosis: Do Their Epidemiological Data Substantiate Infectious Etiologies?
    Infect Dis Rep 2016 Mar 21;8(1):6418. Epub 2016 Mar 21.
    JC School of Public Health and Primary Care, The Chinese University of Hong Kong and Prince of Wales Hospital , Shatin, Hong Kong.
    Many clinical and laboratory-based studies have been reported for skin rashes which may be due to viral infections, namely pityriasis rosea (PR), Gianotti-Crosti syndrome (GCS), asymmetric periflexural exanthem/unilateral laterothoracic exanthem (APE/ULE), papular-purpuric gloves and socks syndrome (PPGSS), and eruptive pseudo-angiomatosis (EP). Eruptive hypomelanosis (EH) is a newly discovered paraviral rash. Novel tools are now available to investigate the epidemiology of these rashes. Read More

    Gianotti-Crosti syndrome as presenting sign of cytomegalovirus infection: A case report and a critical appraisal of its possible cytomegalovirus etiology.
    J Clin Virol 2016 May 19;78:120-2. Epub 2016 Mar 19.
    IRCCS A.O.U. San Martino-IST, Department of Dermatology, Largo Rosanna Benzi 10, Genoa 16132, Italy.
    Gianotti-Crosti syndrome (GCS) is a self-limiting exanthem of acute onset with a characteristic acral distribution, usually occurring in children. It is characterized by symmetric pink to red-brown papular or papulovesicular lesions that are a few millimetres in diameter, distributed on the face, buttocks and limbs. It may be accompanied by low-grade fever, hepato-splenomegaly and lymphadenopathy. Read More

    The diagnostic accuracy of serological tests for Lyme borreliosis in Europe: a systematic review and meta-analysis.
    BMC Infect Dis 2016 Mar 25;16:140. Epub 2016 Mar 25.
    National Institute for Public Health and the Environment (RIVM), Antonie van Leeuwenhoeklaan 9, 3721 MA, Bilthoven, The Netherlands.
    Background: Interpretation of serological assays in Lyme borreliosis requires an understanding of the clinical indications and the limitations of the currently available tests. We therefore systematically reviewed the accuracy of serological tests for the diagnosis of Lyme borreliosis in Europe.

    Methods: We searched EMBASE en MEDLINE and contacted experts. Read More

    The Functions of Metallothionein and ZIP and ZnT Transporters: An Overview and Perspective.
    Int J Mol Sci 2016 Mar 4;17(3):336. Epub 2016 Mar 4.
    Division of Integrated Life Science, Graduate School of Biostudies, Kyoto University, Kyoto 606-8502, Japan.
    Around 3000 proteins are thought to bind zinc in vivo, which corresponds to ~10% of the human proteome. Zinc plays a pivotal role as a structural, catalytic, and signaling component that functions in numerous physiological processes. It is more widely used as a structural element in proteins than any other transition metal ion, is a catalytic component of many enzymes, and acts as a cellular signaling mediator. Read More

    A Case of Acrodermatitis Continua of Hallopeau Following Chronic Pustular Cheilitis.
    Dermatol Ther (Heidelb) 2016 Mar 26;6(1):89-94. Epub 2016 Feb 26.
    Department of Dermatology, Spedali Civili di Brescia, University of Brescia, Brescia, Italy.
    We describe the case of a young male affected by chronic pustular psoriasis of the lips that remained the only manifestation of acrodermatitis continua of Hallopeau (ACH) for years before the onset of the characteristic hand lesions. Read More

    Acrodermatitis Dysmetabolica in a Child with Cystic Fibrosis.
    Pediatr Dermatol 2016 Mar-Apr;33(2):e93-4. Epub 2016 Feb 9.
    Princess Margaret Hospital, Perth, Western Australia, Australia.
    Acrodermatitis dysmetabolica is an umbrella term encompassing the other metabolic causes of an erosive periorificial and acral dermatitis that mimics acrodermatitis enteropathica. Causes include acquired zinc, amino acid, biotin, and fatty acid deficiencies. We present the case of an exclusively breastfed, 2-month-old boy with known cystic fibrosis admitted with failure to thrive and erosive dermatitis. Read More

    Expanding the clinicopathological spectrum of late cutaneous Lyme borreliosis (acrodermatitis chronica atrophicans [ACA]): A prospective study of 20 culture- and/or polymerase chain reaction (PCR)-documented cases.
    J Am Acad Dermatol 2016 Apr 9;74(4):685-92. Epub 2016 Jan 9.
    Clinique Dermatologique, Hôpitaux Universitaires de Strasbourg, Faculté de Médecine, Université de Strasbourg, Strasbourg, France. Electronic address:
    Background: The diagnosis of acrodermatitis chronica atrophicans (ACA), the late cutaneous manifestation of Lyme borreliosis, can be challenging. Histologic changes in ACA have been described in a few studies from endemic countries, relying on cases documented by serology only.

    Objectives: We sought to reassess the clinicopathological spectrum of ACA in a series of thoroughly documented cases. Read More

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