2,667 results match your criteria Gianotti-Crosti Syndrome Papular Acrodermatitis of Childhood


Treatment of acrodermatitis continua of Hallopeau: A case series of 39 patients.

J Dermatol 2020 Jul 6. Epub 2020 Jul 6.

Department of Dermatology, Venereology and Allergology, University Medical Center, Göttingen, Germany.

Acrodermatitis continua of Hallopeau (ACH) is a rare chronic inflammatory skin disease. Treatment is extremely challenging and mostly based on empirics as there is only scarce evidence from case reports and few small case series. In this retrospective study, patients with ACH treated at five university medical centers were analyzed according to patient and disease characteristics and treatment experience. Read More

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http://dx.doi.org/10.1111/1346-8138.15466DOI Listing

Biologics in the treatment of pustular psoriasis.

Expert Opin Drug Saf 2020 Jul 2:1-11. Epub 2020 Jul 2.

Department of Dermatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing, China.

Introduction: Pustular psoriasis is a group of skin diseases characterized by neutrophil infiltration in the epidermis and formation of sterile pustules. Conventional treatments, such as retinoids and immunosuppressive drugs, have improved the clinical manifestations; however, many patients suffer from drug-related toxicity or are resistant to therapy.

Areas Covered: In this review, the authors focus on the efficacy and safety of these biologics, including anti-IL-1β (gevokizumab and canakinumab), anti-IL-1 R (anakinra), anti-IL-36 R (BI 655130), anti-tumor necrosis factor-α (etanercept, infliximab, and adalimumab), anti-IL-12/23 (ustekinumab), anti-IL-17A (secukinumab and ixekizumab), anti-IL-17RA (brodalumab), anti-IL-2 R (basiliximab), anti-IL-6 R (tocilizumab), and anti-IL-23 (risankizumab and guselkumab), for treating pustular psoriasis. Read More

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http://dx.doi.org/10.1080/14740338.2020.1785427DOI Listing

Clinical characteristics, genetics, comorbidities and treatment of palmoplantar pustulosis: A retrospective analysis of 66 cases in a single center in Taiwan.

J Dermatol 2020 Jul 1. Epub 2020 Jul 1.

Department of Dermatology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan.

We retrospectively analyzed 66 patients with palmoplantar pustulosis (PPP) from January 1994 to September 2019 in our department. Interleukin-36 receptor antagonist gene (IL36RN) intron 3 c.115+6T>C mutation was present in two out of 27 patients (7. Read More

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http://dx.doi.org/10.1111/1346-8138.15470DOI Listing

Acrodermatitis Enteropathica as a Presentation of Cystic Fibrosis in an Infant.

Indian Pediatr 2020 Jun;57(6):573

Kanchi Kamakoti CHILDS Trust Hospital, Chennai, India.

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Acrodermatitis chronica atrophicans by Borrelia afzelii in an unusual geographical zone.

Rheumatology (Oxford) 2020 Jun 13. Epub 2020 Jun 13.

Department of Dermatology, Universidad Autónoma de Nuevo León, Hospital Universitario 'Dr José Eleuterio González', Monterrey, Nuevo León, México.

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http://dx.doi.org/10.1093/rheumatology/keaa275DOI Listing
June 2020
4.475 Impact Factor

Presentation of Acrodermatitis Chronica Atrophicans Rashes on Lyme Disease Patients in Canada.

Authors:
John D Scott

Healthcare (Basel) 2020 Jun 4;8(2). Epub 2020 Jun 4.

International Lyme and Associated Diseases Society, 2 Wisconsin Circle, Suite 700, Chevy Chase, MD 20815-7007, USA.

Lyme disease (Lyme borreliosis) is a complex multisystem illness with varying clinical manifestations. This tick-borne zoonosis is caused by the spirochetal bacterium, Borrelia burgdorferi sensu lato (Bbsl) and, worldwide, presents with at least 20 different types of rashes. Certain cutaneous rashes are inherently interconnected to various stages of Lyme disease. Read More

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http://dx.doi.org/10.3390/healthcare8020157DOI Listing

Intramatricial methotrexate for treatment of resistant acrodermatitis continua of Hallopeau: An alternative in COVID-19.

Dermatol Ther 2020 Jun 8:e13787. Epub 2020 Jun 8.

Department of Dermatology, Venereology and Leprosy, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, Karnataka, India.

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http://dx.doi.org/10.1111/dth.13787DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7300587PMC

Lyme borreliosis: diagnosis and management.

BMJ 2020 May 26;369:m1041. Epub 2020 May 26.

Amsterdam University Medical Centers, location AMC, Department of Medicine, Division of Infectious Diseases, and Amsterdam Multidisciplinary Lyme borreliosis Center, Amsterdam, Netherlands.

Lyme borreliosis is the most common vectorborne disease in the northern hemisphere. It usually begins with erythema migrans; early disseminated infection particularly causes multiple erythema migrans or neurologic disease, and late manifestations predominantly include arthritis in North America, and acrodermatitis chronica atrophicans (ACA) in Europe. Diagnosis of Lyme borreliosis is based on characteristic clinical signs and symptoms, complemented by serological confirmation of infection once an antibody response has been mounted. Read More

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http://dx.doi.org/10.1136/bmj.m1041DOI Listing

Acrodermatitis enteropathica: a hereditary form of zinc deficiency.

QJM 2020 May 22. Epub 2020 May 22.

Division of Pediatric Endocrinology and Metabolism, Children's Medical Center, Osaka City General Hospital, 2-13-22, Miyakojima-Hondori, Miyakojima, Osaka, Japan.

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http://dx.doi.org/10.1093/qjmed/hcaa176DOI Listing

Alopecia universalis-like hair loss in acrodermatitis enteropathica.

Clin Exp Dermatol 2020 May 19. Epub 2020 May 19.

Department of Dermatology, Leicester Royal Infirmary, Leicester, UK.

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http://dx.doi.org/10.1111/ced.14232DOI Listing

Is 640 nm high-fluence visible red light a valuable adjunct for treating pemphigus vegetans? A single case report.

J Cosmet Dermatol 2020 May 2. Epub 2020 May 2.

Departments of Dermatology, The Eighth Affiliated Hospital Sun Yat-sen University, Shenzhen, China.

Background: Pemphigus vegetans is an autoimmune bullous disorder characterized by vegetating lesions commonly over the flexures. This disorder is characterized by vegetating lesions more commonly over flexures. Cerebriform tongue, a morphology with typical pattern of sulci and gyri over dorsum of the tongue, is a well-known sign seen in pemphigus vegetans. Read More

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http://dx.doi.org/10.1111/jocd.13420DOI Listing

[Exanthem and painful leg in a 72-year-old female patient].

Authors:
S Macagnino

Internist (Berl) 2020 Jun;61(6):617-620

Krankenhaus Bad Waldsee, Oberschwabenklinik gGmbH, Robert-Koch-Straße 38, 88339, Bad Waldsee, Deutschland.

The case of a 72-year-old female patient with exanthem and concomitant neuropathy of the instep of the foot and progressive ipsilateral lower leg pain is reported. Sonographically, a superficial vein thrombosis with extension into the deep venous system originating from the exanthem was observed. On the basis of the clinical picture as well as the serological and electrophysiological findings, a rare diagnosis of acrodermatitis chronica atrophicans with peripheral neuropathy was made, which could significantly promote the local development of venous thrombosis. Read More

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http://dx.doi.org/10.1007/s00108-020-00792-2DOI Listing

Necrolytic Acral Erythema: Current Insights.

Clin Cosmet Investig Dermatol 2020 5;13:275-281. Epub 2020 Apr 5.

Department of Dermatology, Venereology and Leprosy, SN Medical College, Bagalkote 587102, Karnataka, India.

Necrolytic acral erythema (NAE) is now considered as a distinct clinical entity. It clinically presents as well demarcated hyperpigmented papules and plaques with thick adherent scales distributed symmetrically over dorsum of feet. It usually develops in patients with Hepatitis C virus (HCV) infection. Read More

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http://dx.doi.org/10.2147/CCID.S189175DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7147628PMC

A novel homozygous mutation p.E88K in maternal SLC30A2 gene as a cause of transient neonatal zinc deficiency.

Exp Dermatol 2020 Jun 23;29(6):556-561. Epub 2020 Apr 23.

Department of Dermatovenereology, West China Hospital, Sichuan University, Chengdu, China.

The SLC30A2 gene encodes zinc transporter ZnT2, which is indispensable for the transport of zinc into the breast milk in the mammary gland. Transient neonatal zinc deficiency (TNZD) is caused by a mutation in the maternal SLC30A2 gene and has a clinical presentation similar to that of acrodermatitis enteropathica (AE). We described the case of a Chinese infant who presented with AE-like lesions 10 days after birth. Read More

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http://dx.doi.org/10.1111/exd.14099DOI Listing

A case of pediatric acrodermatitis continua of Hallopeau successfully treated with adalimumab biosimilar.

Dermatol Ther 2020 May 3;33(3):e13327. Epub 2020 Apr 3.

Section of Dermatology, Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy.

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http://dx.doi.org/10.1111/dth.13327DOI Listing

Spesolimab: A Novel Treatment for Pustular Psoriasis.

J Cutan Med Surg 2020 Mar/Apr;24(2):199-200

54473 507266 Division of Dermatology, McGill University Health Centre, Montreal General Hospital, QC, Canada.

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http://dx.doi.org/10.1177/1203475419888862DOI Listing

Acrodermatitis Enteropathica.

J Pediatr 2020 May 21;220:258-259. Epub 2020 Feb 21.

Department of Dermatology, Venereology and Leprology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.

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http://dx.doi.org/10.1016/j.jpeds.2020.01.017DOI Listing
May 2020
3.790 Impact Factor

Efficacy and safety of TNF blockers and of ustekinumab in palmoplantar pustulosis and in acrodermatitis continua of Hallopeau.

J Eur Acad Dermatol Venereol 2020 Feb 6. Epub 2020 Feb 6.

Dermatology Department, Hôpital Robert-Debré, Reims, France.

Background: Palmoplantar pustulosis (PPP) and acrodermatitis continua of Hallopeau (ACH) are rare variants of psoriasis. Knowledge of the efficacy of biologics is scarce.

Objectives: To evaluate the real-life efficacy of tumour necrosis factor blockers and ustekinumab in PPP and in ACH. Read More

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http://dx.doi.org/10.1111/jdv.16265DOI Listing
February 2020

Analysis of the relationship between the mutation site of the SLC39A4 gene and acrodermatitis enteropathica by reporting a rare Chinese twin: a case report and review of the literature.

BMC Pediatr 2020 Jan 27;20(1):34. Epub 2020 Jan 27.

Dermatology Hospital of Southern Medical University, Guangzhou, China.

Background: Acrodermatitis enteropathica (AE) is a rare autosomal recessive hereditary skin disease caused by mutations in the SLC39A4 gene and is characterized by periorificial dermatitis, alopecia and diarrhoea due to insufficient zinc absorption. Only one of the three known sets of twins with AE has genetic information. This case reports the discovery of new mutation sites in rare twin patients and draws some interesting conclusions by analysing the relationship between genetic information and clinical manifestations. Read More

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http://dx.doi.org/10.1186/s12887-020-1942-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6983971PMC
January 2020

Elucidating the H Coupled Zn Transport Mechanism of ZIP4; Implications in Acrodermatitis Enteropathica.

Int J Mol Sci 2020 Jan 22;21(3). Epub 2020 Jan 22.

Department of Physiology and Cell Biology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva 84105, Israel.

Cellular Zn homeostasis is tightly regulated and primarily mediated by designated Zn transport proteins, namely zinc transporters (ZnTs; SLC30) that shuttle Zn efflux, and ZRT-IRT-like proteins (ZIPs; SLC39) that mediate Zn influx. While the functional determinants of ZnT-mediated Zn efflux are elucidated, those of ZIP transporters are lesser understood. Previous work has suggested three distinct molecular mechanisms: (I) HCO3 or (II) H coupled Zn transport, or (III) a pH regulated electrodiffusional mode of transport. Read More

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http://dx.doi.org/10.3390/ijms21030734DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7037870PMC
January 2020

Pustular Psoriasis: The Dawn of a New Era.

Authors:
Hervez Bachelez

Acta Derm Venereol 2020 Jan 30;100(3):adv00034. Epub 2020 Jan 30.

Department of Dermatology, Université de Paris; APHP Hôpital Louis, FR-75010 Paris, France.

Pustular psoriasis is a clinically heterogeneous entity of different, orphan disease subtypes, among which the most clearly defined are generalized pustular psoriasis, palmoplantar psoriasis, and acrodermatitis continua of Hallopeau. Although phenotypically and genetically distinct from psoriasis vulgaris, these subtypes may be associated with plaque psoriasis lesions, establishing the rationale for their inclusion in the psoriasis spectrum. Unlike psoriasis, however, their genetic background is thought to be mainly monogenic, as shown by the recent identification of mutations in 3 different genes of the skin innate immune system; IL36RN, CARD14 and AP1S3. Read More

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http://dx.doi.org/10.2340/00015555-3388DOI Listing
January 2020

Genomics-based treatment in a patient with two overlapping heritable skin disorders: Epidermolysis bullosa and acrodermatitis enteropathica.

Hum Mutat 2020 May 25;41(5):906-912. Epub 2020 Jan 25.

Department of Dermatology and Cutaneous Biology, Sidney Kimmel Medical College and Jefferson Institute of Molecular Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania.

Next-generation sequencing (NGS) is helpful in diagnosing complex genetic disorders and phenotypes, particularly when more than one overlapping condition is present. From a large cohort of 362 families with clinical manifestations of skin and mucosal fragility, referred by several major medical centers, one patient was found by NGS to have two overlapping heritable skin diseases, recessive dystrophic epidermolysis bullosa (RDEB; COL7A1 mutations) and acrodermatitis enteropathica (AE; SLC39A4 mutations). The pathogenicity of the variants was studied at gene expression as well as ultrastructural and tissue levels. Read More

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http://dx.doi.org/10.1002/humu.23980DOI Listing
May 2020
5.144 Impact Factor

[Lyme Borreliosis: Cutaneous and Neurologic Manifestations, Case Definitions and Therapy].

Dtsch Med Wochenschr 2020 01 8;145(1):19-28. Epub 2020 Jan 8.

Lyme borreliosis is the most common zoonosis in Germany with an incidence of up to 138/100 000. More than 90 % of all cases show dermatological manifestations. Early manifestations are erythema migrans, multiple erythemata migrantia, and (less frequently) borrelial lymphocytoma. Read More

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http://dx.doi.org/10.1055/a-0793-4513DOI Listing
January 2020

Cutaneous manifestations of HAV, HBV, HCV.

G Ital Dermatol Venereol 2019 Dec 4. Epub 2019 Dec 4.

DISSAL, Department of Dermatology, Ospedale Policlinico San Martino, Genoa, Italy.

Hepatotropic viral infections are a relevant global health problem and present multiple extrahepatic manifestations in addition to hepatic disease. Along with generic cutaneous symptoms correlated to the cholestatic liver disease that may arise during the infection, some cutaneous manifestations of hepatotropic viral infections are characteristic, enabling to suspect the underlying infection. This review will present the principal cutaneous manifestations of hepatotropic virus infection. Read More

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http://dx.doi.org/10.23736/S0392-0488.19.06488-5DOI Listing
December 2019

Effectiveness of brodalumab in acrodermatitis continua of Hallopeau: A case report.

Dermatol Ther 2020 01 11;33(1):e13170. Epub 2019 Dec 11.

Department of Health Sciences, University Magna Graecia of Catanzaro, Catanzaro, Italy.

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http://dx.doi.org/10.1111/dth.13170DOI Listing
January 2020

Acrodermatitis Enteropathica Associated With Inflammatory Bowel Disease.

ACG Case Rep J 2019 Sep 29;6(9):e00209. Epub 2019 Aug 29.

Division of Gastroenterology, Hackensack University (Palisades) Medical Center, North Bergen, NJ.

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http://dx.doi.org/10.14309/crj.0000000000000209DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6831137PMC
September 2019

[Cutaneous manifestations of nutritional deficiencies].

Rev Med Suisse 2019 Nov;15(672):2125-2130

Service de médecine interne, Département de médecine, CHUV, 1011 Lausanne.

In elderly or chronically ill patients, nutritional deficiencies are common and the presence of related skin lesions is not unusual. Recognition of such cutaneous involvement is important regarding the diagnosis essentially based on clinical elements. By using some clinical case reports, we will describe several pathologies related to nutritional deficiencies like scurvy, pellagra and acquired acrodermatitis enteropathica. Read More

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November 2019

Image Gallery: Pemphigus vulgaris mimicking acrodermatitis continua of Hallopeau.

Br J Dermatol 2020 Apr 19;182(4):e115. Epub 2019 Nov 19.

Department of Dermatology, Peking University People's Hospital, Beijing, China.

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http://dx.doi.org/10.1111/bjd.18599DOI Listing

Concurrence of Acrodermatitis Enteropathica and Eczema Herpeticum in a Child with Atopic Dermatitis.

Case Rep Dermatol 2019 Sep-Dec;11(3):240-248. Epub 2019 Sep 10.

Department of Dermatology and Venereology, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada/Dr. Sardjito Hospital, Yogyakarta, Indonesia.

Acrodermatitis enteropathica (AcE) is a rare, autosomal recessive inherited disorder caused by mutation of the gene coding for zinc transport protein (ZIP 4). The disease appears during childhood especially in breastfeeding or post-breastfeeding infant. Eczema herpeticum refers to a disseminated skin infection of herpes simplex virus that usually leads to vesicular eruptions commonly seen on a background of atopic dermatitis (AD). Read More

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http://dx.doi.org/10.1159/000502509DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6787433PMC
September 2019
50 Reads

Treatment of Recalcitrant Acrodermatitis Continua of Hallopeau With Brodalumab

J Drugs Dermatol 2019 Oct;18(10):1047

To the Editor: Acrodermatitis continua of Hallopeau (ACH) is a relatively rare chronic disorder with clinical findings of pustules and erythematous plaques on the digits.1 Although it is a variant of pustular psoriasis, it can be resistant to multiple lines of therapy. We describe for the first time a patient with recalcitrant ACH successfully treated with brodalumab, an interleukin-17 receptor A (IL-17RA) blocking antibody. Read More

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October 2019

Acrodermatitis continua of Hallopeau: clinical perspectives.

Psoriasis (Auckl) 2019 9;9:65-72. Epub 2019 Aug 9.

Department of Dermatology, University of California, San Francisco, CA, USA.

Acrodermatitis continua of Hallopeau (ACH) is a rare, sterile pustular eruption of one or more digits. The condition presents with tender pustules and underlying erythema on the tip of a digit, more frequently arising on a finger than a toe. As far as classification, ACH is considered a localized form of pustular psoriasis. Read More

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http://dx.doi.org/10.2147/PTT.S180608DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6691962PMC
August 2019
1 Read

Acquired Acrodermatitis Enteropathica.

JAMA Dermatol 2019 Aug 28. Epub 2019 Aug 28.

Department of Dermatology, Venereology and Leprology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

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http://dx.doi.org/10.1001/jamadermatol.2019.2342DOI Listing
August 2019
2 Reads

Case Report: Paradoxical acrodermatitis of Hallopeau-like eruption following anti-IL-17 therapy.

F1000Res 2019 26;8:336. Epub 2019 Mar 26.

Unit of Dermatology, Department of Medicine, University of Padua, Padova, 35121, Italy.

Psoriasis is a chronic immune-mediated inflammatory disease. Up to 40% of patients with psoriasis may develop psoriatic arthritis.  Currently, interleukin (IL)-17/IL-23 pathways are identified as key factors in the immunopathogenesis of both conditions. Read More

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http://dx.doi.org/10.12688/f1000research.18493.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6685451PMC
June 2020
5 Reads

Serological diagnostics of Lyme borreliosis: comparison of assays in twelve clinical laboratories in Northern Europe.

Eur J Clin Microbiol Infect Dis 2019 Oct 9;38(10):1933-1945. Epub 2019 Aug 9.

Division of Clinical Microbiology, Laboratory Medicine, Jönköping Region Jönköping County, Sweden and Department of Clinical and Experimental Medicine, Linköping University, Ryhov County Hospital, SE-551 85, Jönköping, Sweden.

Lyme borreliosis (LB), caused by spirochetes belonging to the Borrelia burgdorferi sensu lato complex, is the most common tick-borne infection in Europe. Laboratory diagnosis of LB is mainly based on the patients' medical history, clinical signs and symptoms in combination with detection of Borrelia-specific antibodies where indirect enzyme-linked-immunosorbent assay (ELISA) is the most widely used technique. The objective of the study was to evaluate and compare the diagnostic accuracy (sensitivities and specificities) of serological tests that are currently in use for diagnosis of LB in clinical laboratories in Northern Europe, by use of a large serum panel. Read More

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http://dx.doi.org/10.1007/s10096-019-03631-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6778534PMC
October 2019
2 Reads

Combined zinc and vitamin B6 deficiency in a patient with diffuse red rash and angular cheilitis 6 years after Roux-en-Y gastric bypass.

BMJ Case Rep 2019 Aug 2;12(8). Epub 2019 Aug 2.

Department of Internal Medicine, School of Medicine, University of Florida, Gainesville, Florida, USA.

A 39-year-old woman with a history of Roux-en-Y gastric bypass (RYGB) surgery and alcohol use presented with a confluent erythematous rash involving the perineum spreading outward to the abdomen, thighs and lower back. She had angular cheilitis and glossitis. The rash was painful and blistering in scattered areas. Read More

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http://dx.doi.org/10.1136/bcr-2019-230605DOI Listing
August 2019
4 Reads

Image Gallery: Acrodermatitis enteropathica: recurrent flares in adulthood.

Br J Dermatol 2019 11 1;181(5):e114. Epub 2019 Aug 1.

Beaumont Hospital, Department of Dermatology, Beaumont Road, Dublin, 9, Ireland.

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http://dx.doi.org/10.1111/bjd.18208DOI Listing
November 2019
1 Read

Acroangiodermatitis of Mali and Stewart-Bluefarb syndrome.

Cutis 2019 Jun;103(6):336-339

Advanced Dermatology Associates LTD, Allentown, USA.

Acroangiodermatitis (AAD), also known as pseudo-Kaposi sarcoma, is a rare benign vascular proliferation mainly of the extremities. It is characterized by violaceous patches or plaques resembling Kaposi sarcoma. The term pseudo-Kaposi sarcoma encompasses 2 variants of acroangiodermatitis: Mali type and Stewart-Bluefarb syndrome (SBS). Read More

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June 2019
5 Reads

Acrodermatitis enteropathica-like skin eruption with neonatal seizures in a child with biotinidase deficiency.

Clin Exp Dermatol 2020 Mar 21;45(2):266-267. Epub 2019 Aug 21.

Department of Dermatology and Venereology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, 110029, India.

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http://dx.doi.org/10.1111/ced.14053DOI Listing
March 2020
8 Reads

Crusted scabies mimicking an acrodermatitis continua of Hallopeau.

Bol Med Hosp Infant Mex 2019 ;76(4):198-202

Dermopatología Clínica e Histología de la Piel. Ciudad de Guatemala, Guatemala.

Background: Crusted scabies (CS) is an uncommon, highly contagious, variant of classic scabies. Elevated concentrations of the mite Sarcoptes scabiei var. hominis are found in the skin lesions, which lead to a more exaggerated clinical picture than in classic scabies. Read More

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http://dx.doi.org/10.24875/BMHIM.19000012DOI Listing
April 2020
4 Reads

Zwei Fälle von Acrodermatitis continua suppurativa (Morbus Hallopeau) unter Behandlung mit IL-17A-Hemmern.

J Dtsch Dermatol Ges 2019 Jun;17(6):643-645

Dermatologie, Venerologie und Allergologie, Universitätsmedizin Göttingen, Göttingen, Deutschland.

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http://dx.doi.org/10.1111/ddg.13857_gDOI Listing
June 2019
1 Read

Two cases of acrodermatitis continua suppurativa (Hallopeau's disease) treated with IL-17A inhibitors.

J Dtsch Dermatol Ges 2019 06;17(6):643-645

Department of Dermatology, Venereology and Allergology, University of Goettingen, Goettingen, Germany.

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http://dx.doi.org/10.1111/ddg.13857DOI Listing
June 2019
4 Reads

Clinical Spectrum of Inherited Disorders of Metabolism.

Indian J Pediatr 2019 10 20;86(10):892-896. Epub 2019 Jun 20.

Kanchi Kamakoti CHILDS Trust Hospital and The CHILDS Trust Medical Research Foundation, 12-A, Nageswara road, Nungambakkam, Chennai, Tamil Nadu, 600034, India.

Objective: To study the clinical profile and outcome of children with Inborn errors of metabolism.

Methods: Thirty one newly diagnosed children with Inborn errors of metabolism over a 1 y period were studied for their relevant clinical, biochemical, diagnosis, treatment and follow-up details.

Results: Inborn errors of metabolism accounted for 2% of hospital admissions. Read More

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http://dx.doi.org/10.1007/s12098-019-02998-1DOI Listing
October 2019
4 Reads

Overlapping dermatologic diagnoses in severe Crohn's disease with duel genetic mutations.

Int J Dermatol 2019 Nov 17;58(11):e214-e216. Epub 2019 Jun 17.

Department of Dermatology, University of Florida College of Medicine, Gainesville, FL, USA.

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http://dx.doi.org/10.1111/ijd.14520DOI Listing
November 2019
1 Read

Outcomes of various types of therapy in patients with treatment-resistant acrodermatitis continua of Hallopeau.

Biologics 2019 20;13:83-87. Epub 2019 May 20.

Department of Dermatology and Venereology, I.M. Sechenov First Moscow State Medical University, Moscow 119991, Russian Federation.

Chronic acrodermatitis continua of Hallopeau (ACH) is a rare form of pustular psoriasis predominantly affecting the distal phalanges of the fingers and toes. The disease manifests by pustular rash with marked infiltration, fissures, and often results into severe dystrophy of nail plates. ACH is refractory to most of psoriasis standard of care (SOC) therapies. Read More

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http://dx.doi.org/10.2147/BTT.S199100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6535620PMC
May 2019
6 Reads

Treatment of acrodermatitis continua of hallopeau with ixekizumab.

J Dermatolog Treat 2019 Jul 5:1-3. Epub 2019 Jul 5.

a Skin Care Physicians of Georgia , Macon , GA , USA.

Acrodermatitis continua of hallopeau (ACH) is a rare chronic inflammatory variant of pustular psoriasis often restricted to the distal portions the digits in the hands and feet. ACH is of a chronic relapsing nature and is invariably recalcitrant to many available topical and systemic anti-psoriatic therapies. On account of its low prevalence and high resistance to treatments, no clinical guideline of ACH exists. Read More

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http://dx.doi.org/10.1080/09546634.2019.1628170DOI Listing
July 2019
8 Reads

Viral exanthems in children: A great imitator.

Clin Dermatol 2019 May - Jun;37(3):213-226. Epub 2019 Jan 11.

Department of Dermatology, University Children's Hospital Niño Jesús, Madrid, Spain. Electronic address:

Viral exanthems are frequent in children and are mostly self-limited. Early recognition and differentiation from other childhood illnesses are important to direct further investigations and treatment initiation. The clinical presentation of viral exanthems in children includes a polymorphic spectrum of skin eruptions ranging from classic viral exanthems to "atypical" presentations that can mimic nonviral diseases; thus, viral exanthems of childhood can be readily diagnosed on clinical grounds, but not rarely do they represent a diagnostic challenge. Read More

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http://dx.doi.org/10.1016/j.clindermatol.2019.01.009DOI Listing
December 2019
2.470 Impact Factor

Hypereosinophilic syndrome masquerading as acrodermatitis enteropathica.

Indian J Dermatol Venereol Leprol 2019 Jul-Aug;85(4):418-422

Department of Dermatology Venereology and Leprosy, Rajiv Gandhi Government General Hospital and Madras Medical College (Affiliated to The Tamil Nadu Dr. M.G.R Medical University) Chennai, Tamil Nadu, India.

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http://dx.doi.org/10.4103/ijdvl.IJDVL_607_17DOI Listing
February 2020
10 Reads

The histidine-rich loop in the extracellular domain of ZIP4 binds zinc and plays a role in zinc transport.

Biochem J 2019 06 28;476(12):1791-1803. Epub 2019 Jun 28.

Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, MI, U.S.A.

The Zrt-/Irt-like protein (ZIP) family mediates zinc influx from extracellular space or intracellular vesicles/organelles, playing a central role in systemic and cellular zinc homeostasis. Out of the 14 family members encoded in human genome, ZIP4 is exclusively responsible for zinc uptake from dietary food and dysfunctional mutations of ZIP4 cause a life-threatening genetic disorder, Acrodermatitis Enteropathica (AE). About half of the missense AE-causing mutations occur within the large N-terminal extracellular domain (ECD), and our previous study has shown that ZIP4-ECD is crucial for optimal zinc uptake but the underlying mechanism has not been clarified. Read More

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http://dx.doi.org/10.1042/BCJ20190108DOI Listing
June 2019
8 Reads

Atomic Absorbance Spectroscopy to Measure Intracellular Zinc Pools in Mammalian Cells.

J Vis Exp 2019 05 16(147). Epub 2019 May 16.

Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School;

Transition metals are essential micronutrients for organisms but can be toxic to cells at high concentrations by competing with physiological metals in proteins and generating redox stress. Pathological conditions that lead to metal depletion or accumulation are causal agents of different human diseases. Some examples include anemia, acrodermatitis enteropathica, and Wilson's and Menkes' diseases. Read More

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http://dx.doi.org/10.3791/59519DOI Listing
May 2019
25 Reads

Gianotti-Crosti syndrome (papular acrodermatitis of childhood) in the era of a viral recrudescence and vaccine opposition.

World J Pediatr 2019 Dec 27;15(6):521-527. Epub 2019 May 27.

Pediatric Institute, Kuala Lumpur General Hospital, Kuala Lumpur, Malaysia.

Background: Gianotti-Crosti syndrome is characterized by an acute onset of a papular or papulovesicular eruption with a symmetrical distribution.

Data Sources: A PubMed search was conducted using Clinical Queries with the key terms "Gianotti-Crosti syndrome" OR "papular acrodermatitis". The search strategy included meta-analyses, randomized controlled trials, clinical trials, observational studies, and reviews. Read More

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http://dx.doi.org/10.1007/s12519-019-00269-9DOI Listing
December 2019
4 Reads