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    2554 results match your criteria Gianotti-Crosti Syndrome Papular Acrodermatitis of Childhood

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    Generalized pustular psoriasis: a review and update on treatment.
    J Eur Acad Dermatol Venereol 2018 Mar 24. Epub 2018 Mar 24.
    Department of Dermatology, Rutgers-New Jersey Medical School, Newark, NJ, USA.
    Generalized pustular psoriasis (GPP) is a subtype of pustular psoriasis characterized by painful and occasionally disfiguring cutaneous manifestations with sepsis-like systemic symptoms. Affecting any age and race, GPP can occur with other forms of psoriasis or by itself. Stimuli for flares include medications, infections and environmental triggers. Read More

    MKLN1 splicing defect in dogs with lethal acrodermatitis.
    PLoS Genet 2018 Mar 22;14(3):e1007264. Epub 2018 Mar 22.
    Institute of Genetics, Vetsuisse Faculty, University of Bern, Bern, Switzerland.
    Lethal acrodermatitis (LAD) is a genodermatosis with monogenic autosomal recessive inheritance in Bull Terriers and Miniature Bull Terriers. The LAD phenotype is characterized by poor growth, immune deficiency, and skin lesions, especially at the paws. Utilizing a combination of genome wide association study and haplotype analysis, we mapped the LAD locus to a critical interval of ~1. Read More

    Acquired bullous acrodermatitis enteropathica as a histologic mimic of pemphigus foliaceus in a patient on parenteral nutrition.
    Dermatol Online J 2017 Jul 15;23(7). Epub 2017 Jul 15.
    Department of Dermatology, Hofstra Northwell School of Medicine, New Hyde Park, New York. vsharon@ northwell.edu.
    Acquired zinc deficiency can develop as a consequence of poor nutritional intake or from dependence on total parenteral nutrition. Acquired zinc deficiency dermatitis classically manifests with erosions and scaly plaques in a periorificial and acral distribution. We present a case of a woman on parenteral nutrition who presented with bullous acrodermatitis mimicking pemphigus foliaceus histopathologically. Read More

    The Role of the Slc39a Family of Zinc Transporters in Zinc Homeostasis in Skin.
    Nutrients 2018 Feb 16;10(2). Epub 2018 Feb 16.
    Division of Pathology, Department of Oral Diagnostic Sciences, School of Dentistry, Showa University, Tokyo 142-8555, Japan.
    The first manifestations that appear under zinc deficiency are skin defects such as dermatitis, alopecia, acne, eczema, dry, and scaling skin. Several genetic disorders including acrodermatitis enteropathica (also known as Danbolt-Closs syndrome) and Brandt's syndrome are highly related to zinc deficiency. However, the zinc-related molecular mechanisms underlying normal skin development and homeostasis, as well as the mechanism by which disturbed zinc homeostasis causes such skin disorders, are unknown. Read More

    Zinc and Skin Disorders.
    Nutrients 2018 Feb 11;10(2). Epub 2018 Feb 11.
    Department of Dermatology, Faculty of Medicine, University of Yamanashi, Yamanashi 409-3898, Japan.
    The skin is the third most zinc (Zn)-abundant tissue in the body. The skin consists of the epidermis, dermis, and subcutaneous tissue, and each fraction is composed of various types of cells. Firstly, we review the physiological functions of Zn and Zn transporters in these cells. Read More

    Acrodermatitis Continua of Hallopeau with Bone Resorption in an 8-Year-Old Patient: A Case Report.
    Case Rep Dermatol 2017 Sep-Dec;9(3):259-264. Epub 2017 Dec 18.
    Department of Dermatology, King Saud University Medical City, Riyadh, Saudi Arabia.
    Acrodermatitis continua of Hallopeau (ACH) is an uncommon inflammatory disease manifesting as sterile pustular eruption of the fingers and toes. The disease is of a chronic relapsing nature and is often refractory to treatment. With longstanding disease, osteitis with consequent bone resorption of the underlying phalanges can occur, leading to disability. Read More

    Autoinflammatory keratinization diseases: An emerging concept encompassing various inflammatory keratinization disorders of the skin.
    J Dermatol Sci 2018 Feb 1. Epub 2018 Feb 1.
    Department of Dermatology, Fujita Health University School of Medicine, Toyoake, Japan.
    Classifying inflammatory skin diseases is challenging, especially for the expanding group of disorders triggered by genetic factors resulting in hyperactivated innate immunity that result in overlapping patterns of dermal and epidermal inflammation with hyperkeratosis. For such conditions, the umbrella term "autoinflammatory keratinization diseases" (AIKD) has been proposed. AIKD encompasses diseases with mixed pathomechanisms of autoinflammation and autoimmunity, and includes IL-36 receptor antagonist (IL-36Ra)-related pustulosis, CARD14-mediated pustular psoriasis, pityriasis rubra pilaris (PRP) type V, and familial keratosis lichenoides chronica (KLC). Read More

    ACRODERMATITIS ENTEROPATHICA: CLINICAL MANIFESTATIONS AND PEDIATRIC DIAGNOSIS.
    Rev Paul Pediatr 2018 Jan 15. Epub 2018 Jan 15.
    Universidade de São Paulo, Ribeirão Preto, São Paulo, Brasil.
    Objective: To report a case of acrodermatitis enteropathica, a rare disease with autosomal recessive inheritance.

    Case Description: An 11-month-old boy was presenting symmetrical erythematous and yellowish-brownish crusted lesions on his face, feet, hands and knees, intermittent diarrhea, fever, and recurrent infections since the age of six months. He was thin and had scarce hair on the scalp. Read More

    Nail psoriasis: clinical features, pathogenesis, differential diagnoses, and management.
    Psoriasis (Auckl) 2017 16;7:51-63. Epub 2017 Oct 16.
    Department of Dermatology, Inselspital, University of Bern, Bern, Switzerland.
    Psoriasis is the skin disease that most frequently affects the nails. Depending on the very nail structure involved, different clinical nail alterations can be observed. Irritation of the apical matrix results in psoriatic pits, mid-matrix involvement may cause leukonychia, whole matrix affection may lead to red lunulae or severe nail dystrophy, nail bed involvement may cause salmon spots, subungual hyperkeratosis, and splinter hemorrhages, and psoriasis of the distal nail bed and hyponychium causes onycholysis whereas that of the proximal nail fold causes psoriatic paronychia. Read More

    [Acrodermatitis enteropathica].
    Bol Med Hosp Infant Mex 2017 Jul - Aug;74(4):295-300. Epub 2017 Jul 5.
    Servicio de Infectología Pediátrica, Centro Médico Nacional 20 de Noviembre, ISSSTE, Ciudad de México, México.
    Introduction: Acrodermatitis enteropathica is a low-incidence disease due to inherited or acquired zinc deficiency. It is characterized by acral dermatitis, alopecia, diarrhea and growth retardation. The dermatological condition may mimic a cutaneous fungal infection or other pathogen-related skin diseases. Read More

    Disorders of metal metabolism.
    Transl Sci Rare Dis 2017 Dec 18;2(3-4):101-139. Epub 2017 Dec 18.
    Section on Human Biochemical Genetics, Medical Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, MD, USA.
    Trace elements are chemical elements needed in minute amounts for normal physiology. Some of the physiologically relevant trace elements include iodine, copper, iron, manganese, zinc, selenium, cobalt and molybdenum. Of these, some are metals, and in particular, transition metals. Read More

    Acrodermatitis acidaemica.
    Clin Exp Dermatol 2018 Apr 15;43(3):315-318. Epub 2018 Jan 15.
    Department of Dermatology, St George's Healthcare NHS Trust, London, UK.
    Methylmalonic acidaemia (MMA) is an inborn error of amino acid metabolism that may be associated with cutaneous manifestations mimicking other diagnoses, including staphylococcal scalded skin syndrome (SSSS), psoriasis and acrodermatitis enteropathica. Whether this is due to the underlying metabolic disorder itself or occurs as a consequence of dietary restriction has yet to be elucidated. Skin biopsies typically show histological features shared by a number of other metabolic disorders and nutritional deficiency-associated diseases. Read More

    Pustular psoriasis and related pustular skin diseases.
    Br J Dermatol 2018 Mar 15;178(3):614-618. Epub 2018 Jan 15.
    Department of Dermatology, AP-HP Hôpital Saint-Louis, 1 Avenue Claude Vellefaux, Paris CEDEX 10, 75475, France.
    Patients with pustular psoriasis or related pustular diseases may have genetic abnormalities impairing the function of key players of the innate skin immune system. Recently, identification of these abnormalities has changed the paradigm of several of these diseases. These include generalized pustular psoriasis, palmoplantar pustular psoriasis and acrodermatitis continua of Hallopeau, and also drug-induced acute exanthematous generalized pustular eruption. Read More

    Septolobular panniculitis in disseminated Lyme borreliosis.
    J Cutan Pathol 2018 Apr 9;45(4):274-277. Epub 2018 Feb 9.
    Departments of Dermatology and Pathology, University of Iowa Hospitals and Clinics, Iowa City, Iowa.
    Lyme disease classically evolves through clinical manifestations according to the stage of illness. Because many of the systemic symptoms are non-specific, and because serology may yield false negative results, cutaneous findings merit even greater importance to diagnosis. The prototypical skin lesion, erythema migrans (EM), occurs early and is the only independent diagnostic clinical feature according to the guidelines of the Infectious Diseases Society of America. Read More

    Correlation of Reflectance Confocal Microscopy and Dermatopathology Findings in a Case of Acrodermatitis Chronica Atrophicans.
    Am J Dermatopathol 2017 Nov 29. Epub 2017 Nov 29.
    Department of Dermatology, Medical University of Graz, Graz, Austria.
    Acrodermatitis chronica atrophicans (ACA) that is characterized by thin, papery dry, translucent, and alopecic patches with visible superficial veins is a late cutaneous manifestation of Lyme borreliosis. Clinical findings, a history of exposure to tick bite, and serology are helpful for the diagnosis of ACA and sometimes a biopsy is performed to rule out other infectious or inflammatory processes. In this study, we report reflectance confocal microscopy (RCM) findings in a case of ACA. Read More

    Skin Lesions Associated with Nutritional Management of Maple Syrup Urine Disease.
    Case Rep Dermatol Med 2017 25;2017:3905658. Epub 2017 Oct 25.
    Division of Nutrition, Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand.
    Introduction: Maple syrup urine disease (MSUD) is an inborn error of branched chain amino acids (BCAAs) metabolism. We report an infant with MSUD who developed 2 episodes of cutaneous lesions as a result of isoleucine deficiency and zinc deficiency, respectively.

    Case Presentation: A 12-day-old male infant was presented with poor milk intake and lethargy. Read More

    Acquired Acrodermatitis Enteropathica: A Case Study.
    Cureus 2017 Sep 8;9(9):e1667. Epub 2017 Sep 8.
    Internal Medicine, University of Central Florida College of Medicine.
    We present a case of severe acquired acrodermatitis enteropathica in a vegan adult female with multiple underlying comorbidities. Acquired acrodermatitis enteropathica or zinc-deficiency dermatitis is the most common diagnosis than many practitioners realize with up to 10% of the patients in developed nations with the risk of zinc deficiency. The condition can be difficult to diagnose due to many similarly-presenting conditions. Read More

    Efficacy and safety of acitretin monotherapy in children with pustular psoriasis: results from 15 cases and a literature review.
    J Dermatolog Treat 2017 Nov 9:1-11. Epub 2017 Nov 9.
    c Institute of Dermatology , Guangzhou Medical University , Guangzhou , P.R. China.
    Background: There is a few evidence-based information regarding the efficacy and safety of acitretin treatment in children with pustular psoriasis (PP).

    Objective: This study aimed to provide an additional evidence for this field.

    Methods: A retrospective study was undertaken for 15 children with PP who received acitretin in doses of 0. Read More

    Cutaneous Lyme borreliosis: Guideline of the German Dermatology Society.
    Ger Med Sci 2017 5;15:Doc14. Epub 2017 Sep 5.
    Klinik für Infektiologie Klinik St Georg, Leipzig, Germany.
    This guideline of the German Dermatology Society primarily focuses on the diagnosis and treatment of cutaneous manifestations of Lyme borreliosis. It has received consensus from 22 German medical societies and 2 German patient organisations. It is the first part of an AWMF (Arbeitsgemeinschaft der Wissenschaftlichen Medizinischen Fachgesellschaften e. Read More

    The genetic basis for most patients with pustular skin disease remains elusive.
    Br J Dermatol 2018 Mar 22;178(3):740-748. Epub 2018 Jan 22.
    Institute of Human Genetics, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.
    Background: Rare variants in the genes IL36RN, CARD14 and AP1S3 have been identified to cause or contribute to pustular skin diseases, primarily generalized pustular psoriasis (GPP).

    Objectives: To better understand the disease relevance of these genes, we screened our cohorts of patients with pustular skin diseases [primarily GPP and palmoplantar pustular psoriasis (PPP)] for coding changes in these three genes. Carriers of single heterozygous IL36RN mutations were screened for a second mutation in IL36RN. Read More

    Diagnosis of acrodermatitis enteropathica in resource limited settings.
    BMJ Case Rep 2017 Aug 2;2017. Epub 2017 Aug 2.
    Department of Dermatology and Venereology, All India Institute of Medical Sciences, New Delhi, India.
    Acrodermatitis enteropathica (AE) is a rare inherited zinc deficiency that usually manifests in infancy within days in cases of bottlefed infants and days to weeks after weaning in breastfed infants. It is characterised by diarrhoea, dermatitis, alopecia and systemic symptoms. We report a case of acquired nutritional AE in a 6-month-old female infant who had diarrhoeal episodes and the characteristic dermatitis lesions in the acral and anogenital regions. Read More

    Characterization of zinc amino acid complexes for zinc delivery in vitro using Caco-2 cells and enterocytes from hiPSC.
    Biometals 2017 Oct 17;30(5):643-661. Epub 2017 Jul 17.
    WG Cellular Neurobiology and Neuro-Nanotechnology, Department of Biological Sciences, University of Limerick, Limerick, Ireland.
    Zn is essential for growth and development. The bioavailability of Zn is affected by several factors such as other food components. It is therefore of interest, to understand uptake mechanisms of Zn delivering compounds to identify ways to bypass the inhibitory effects of these factors. Read More

    Typical and atypical clinical appearance of atopic dermatitis.
    Clin Dermatol 2017 Jul - Aug;35(4):354-359. Epub 2017 Mar 24.
    Icahn School of Medicine at Mt Sinai, New York, NY. Electronic address:
    Atopic dermatitis is a complex, systemic inflammatory disorder associated with a variety of clinical features. The original criteria of Hanifin and Rajka include major criteria and a list of about two dozen minor criteria however, even the minor criteria do not include some features of atopic dermatitis noted less commonly but still seen with some frequency. This contribution first reviews the common clinical appearance of atopic dermatitis in infancy, childhood, and adulthood, as well as the less typical appearances, including lichenoid atopic dermatitis; juvenile plantar dermatosis; nummular-type atopic dermatitis; follicular atopic dermatitis; alopecia of atopic dermatitis; eczema coxsackium; and psoriasiform, perineal, and lip licker's dermatitis. Read More

    Necrolytic Acral Erythema in Seronegative Hepatitis C.
    Case Rep Dermatol 2017 Jan-Apr;9(1):69-73. Epub 2017 Mar 17.
    Division of Dermatology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
    Necrolytic acral erythema (NAE) is a distinctive skin disorder. The exact cause and pathogenesis is still unclear. Most studies report an association of NAE with hepatitis C virus (HCV) infection. Read More

    [Analysis of SLC39A4 gene mutation in a patient with acrodermatitis enteropathica].
    Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2017 Jun;34(3):387-389
    Department of Dermatology, the Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan 637000, China.
    Objective: To detect pathogenic mutation of the SLC39A4 gene in a male patient with acrodermatitis enteropathica (AE).

    Methods: Peripheral venous blood sample and clinical data from the patient and his parents were collected. One hundred unrelated healthy individuals were recruited as controls. Read More

    European consensus statement on phenotypes of pustular psoriasis.
    J Eur Acad Dermatol Venereol 2017 Nov 29;31(11):1792-1799. Epub 2017 Aug 29.
    Division of Genetics and Molecular Medicine, King's College, London, UK.
    Pustular psoriasis (PP) is a group of inflammatory skin conditions characterized by infiltration of neutrophil granulocytes in the epidermis to such an extent that clinically visible sterile pustules develop. Because of clinical co-incidence, PP is currently grouped with psoriasis vulgaris (PV). However, PP and PV are phenotypically different, respond differently to treatments and seem to be distinct on the genetic level. Read More

    Short- and Long-Term Management of an Acute Pustular Psoriasis Flare: A Case Report.
    J Cutan Med Surg 2017 Sep/Oct;21(5):452-456. Epub 2017 May 23.
    2 Faculty of Medicine, University of Toronto, Toronto, ON, Canada.
    Background: Generalised pustular psoriasis (GPP) and acrodermatitis continua of Hallopeau (ACH) are chronic, relapsing variants of pustular psoriasis proven to be remarkably challenging to treat. Due to their uncommon presentation, there are few described cases in literature and scarce evidence for management. Further information is needed to help dermatologists formulate treatment plans for patients presenting with such diseases. Read More

    Adult autoimmune enteropathy presenting initially with acquired Acrodermatitis Enteropathica: a case report.
    BMC Dermatol 2017 May 18;17(1). Epub 2017 May 18.
    Department of Dermatology, Johns Hopkins University School of Medicine, 1550 Orleans Street, Koch CRB II, Unit 206, Baltimore, MD, 21231, USA.
    Background: Acrodermatitis enteropathica (AE) is a rare dermatitis secondary to zinc deficiency most commonly seen as an inherited disease in infants. In the last decade, increased number of reports have been published on the acquired form that presents in adulthood. Unlike its inherited counterpart, acquired AE (AAE) is often secondary to underlying pathologic or iatrogenic etiologies that interfere with nutritional absorption, such as inflammatory bowel disease or alcoholism. Read More

    A foot tumour as late cutaneous Lyme borreliosis: a new entity?
    Br J Dermatol 2017 Oct 8;177(4):1127-1130. Epub 2017 Sep 8.
    Dermatology Department, Nancy University Hospital, Vandoeuvre-les-Nancy, France.
    Acrodermatitis chronica atrophicans (ACA) is the late cutaneous form of Lyme borreliosis. The early inflammatory phase manifests with a bluish-red discoloration and doughy swelling of the skin. The atrophic phase represents a late-phase process with red discoloration, and a thin and wrinkled appearance of the skin. Read More

    Acrodermatitis enteropathica in a pair of twins.
    J Dermatol Case Rep 2016 Dec 31;10(4):65-67. Epub 2016 Dec 31.
    Department of Dermatology, College of Medicine, King Faisal University, Al-Ahsa, Saudi Arabia.
    Background: Acrodermatitis enteropathica (AE) is a rare autosomal recessive metabolic disorder. First described by Brandt in 1936 and was named by Danbolt. A mutation in the SLC39A4 gene on chromosome 8 q24. Read More

    Advances in pharmacotherapeutic management of common skin diseases in neonates and infants.
    Expert Opin Pharmacother 2017 May 21;18(7):717-725. Epub 2017 Apr 21.
    a Dermatology, Department of Experimental, Diagnostic and Specialty Medicine , Sant'Orsola-Malpighi Hospital, University of Bologna , Bologna , Italy.
    Introduction: neonatal and infantile skin diseases are frequently encountered in the clinical practice and represent worldwide a socioeconomic issue. They encompass a wide range of acquired or congenital conditions, including infections, vascular lesions and inflammatory diseases and can present with different degrees of severity, leading in some cases to dramatic complications. Areas covered: In this paper we report the most recent evidences on the management of some common skin diseases in neonates and infants. Read More

    Brief Report: HPV-17 Infection in Darier Disease With Acrokeratosis Verrucosis of Hopf.
    Am J Dermatopathol 2017 May;39(5):370-373
    *Divisions of Dermatopathology and Dermatology, Department of Pathology, Albany Medical College, Albany, NY; †Division of Dermatology, Upper Hudson Valley Dermatology, Castleton, NY; and ‡Departments of Dermatology, Microbiology/Medical Genetics, and Internal Medicine, University of Texas Health Science Center, Houston, TX.
    The co-existence of Darier disease (DD) and acrokeratosis verruciformis of Hopf (AKV) has been noted for decades and the relationship between the 2 entities remains controversial. Although, it has been shown that both diseases are associated with mutations in ATPA2 gene, it is yet to be determined if they are the same disease, or separate but allelic, or interlinked in some other fashion. Herein, the authors report the case of a 13-year-old girl presenting with shiny flat-topped verruca plana-like papules, on the dorsal hands and feet and red-brown crusted papules on her forehead and along the sides of her neck. Read More

    Acquired Acrodermatitis Enteropathica Syndrome in a Kidney Transplant Receipt: A Case Report.
    Transplant Proc 2017 Apr;49(3):609-612
    Department of General Surgery, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.
    Acrodermatitis enteropathica syndrome (AE) is a clinical entity that results in severe zinc deficiency. It can be genetic or acquired. Acquired AE has been reported in patients with chronic liver disease, malabsorption syndrome, sickle cell anemia, and chronic renal failure. Read More

    Gianotti-Crosti syndrome: a case report of a teenager.
    An Bras Dermatol 2016 Sep-Oct;91(5 suppl 1):163-165
    Universidade do Estado do Rio de Janeiro (UERJ) - Rio de Janeiro (RJ), Brazil.
    Gianotti-Crosti syndrome is a rare disease characterized by acral papular eruption with symmetrical distribution. It is a benign and self-limited disease; the symptoms disappear after two to eight weeks, without recurrences or scars. Skin lesions are usually asymptomatic. Read More

    Depletion of Epidermal Langerhans Cells in the Skin Lesions of Pellagra Patients.
    Am J Dermatopathol 2017 Jun;39(6):428-432
    *Department of Dermatology, University of the Ryukyus, Okinawa, Japan; †Department of Dermatology, Tone-chuo Hospital, Numata, Japan; ‡Department of Dermatology, Gunma University, Maebashi, Japan; §Department of Dermatology, Wakayama Medical University, Wakayama, Japan; ¶Department of Dermatology, Nagasaki University, Nagasaki, Japan; and ‖Department of Dermatology, Saitama Medical University Saitama Medical Center, Kawagoe, Japan.
    Pellagra is a nutrient deficiency disease caused by insufficient niacin levels. Recent studies have shown that numbers of epidermal Langerhans cells decreased in other diseases caused by nutritional deficiencies, including necrolytic migratory erythema and acrodermatitis enteropathica. Epidermal Langerhans cells are capable of modulating or even halting the inflammatory reaction. Read More

    Perianal Lesions in Children: An Updated Review.
    Am J Clin Dermatol 2017 Jun;18(3):343-354
    Department of Dermatology, State University of New York Downstate Medical Center, 10 West, 800 Poly Place, Brooklyn, NY, 11203, USA.
    Perianal lesions in children are common reasons for dermatology clinic visits and a well-defined approach to diagnosis and management is helpful to the practicing clinician. In this article, we review and update various etiologies of perianal lesions in the pediatric population, including infectious, papulosquamous, vascular, and neoplastic. We provide a standard initial approach to diagnosis and updates on current management. Read More

    [Cutaneous manifestations of Lyme disease : Pitfalls in the serological diagnostic workup].
    Hautarzt 2017 Apr;68(4):329-339
    Abteilung für Dermatologie, Landesklinikum Wiener Neustadt, Wiener Neustadt, Österreich.
    Serology, the detection of B. burgdorferi-specific IgM and IgG serum antibodies, is the most common laboratory test to diagnose cutaneous manifestations of Lyme disease. In a two-tiered approach, an ELISA is used as a screening test. Read More

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