12,742 results match your criteria Ghana medical journal[Journal]


Feasibility study on direct fermentation of soybean meal by Bacillus stearothermophilus under non-sterile conditions.

J Sci Food Agric 2018 Dec 15. Epub 2018 Dec 15.

School of Food & Biological Engineering, Jiangsu University, Zhenjiang, 212003, China.

Background: To evaluate the feasibility of high-temperature solid-state fermentation using soybean meal (SBM) during the non-sterile process, Bacillus stearothermophilus was employed to assess the nutritional quality and bioactivity of SBM after fermentation.

Results: The fermented SBM (FSBM) without autoclaving showed significant improvements in nutritional quality and bioactivity. The contents of peptides and, crude and soluble proteins increased by 131. Read More

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December 2018
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Temporal trend and spatial clustering of cholera epidemic in Kumasi-Ghana.

Sci Rep 2018 Dec 14;8(1):17848. Epub 2018 Dec 14.

Faculty of Geo-Information Science and Earth Observation (ITC), University of Twente, Enschede, Netherlands.

Knowledge of the temporal trends and spatial patterns will have significant implications for effective preparedness in future epidemics. Our objective was to investigate the temporal trends and the nature of the spatial interaction of cholera incidences, dwelling on an outbreak in the Kumasi Metropolis, Ghana. We developed generalized nonparametric and segmented regression models to describe the epidemic curve. Read More

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December 2018
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Is the decline in neonatal mortality in northern Ghana, 1996-2012, associated with the decline in the age of BCG vaccination? An ecological study.

BMJ Open 2018 Dec 14;8(12):e023752. Epub 2018 Dec 14.

Navrongo Health Research Centre, Navrongo, Ghana.

Objective: To examine the association between early Bacille Calmette-Guerin (BCG) vaccination and neonatal mortality in northern Ghana.

Methods: This ecological study used vaccination and mortality data from the Navrongo Health and Demographic Surveillance System. First, we assessed and compared changes in neonatal mortality rates (NMRs) and median BCG vaccination age from 1996 to 2012. Read More

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December 2018

Perceptions of climate change and occupational heat stress risks and adaptation strategies of mining workers in Ghana.

Sci Total Environ 2018 Dec 5;657:365-378. Epub 2018 Dec 5.

Edith Cowan University, Perth, Western Australia, Australia; Ghana Institute of Management and Public Administration, Ghana. Electronic address:

Heavy physical workload for long hours coupled with increasing workplace heat exposure due to rising temperatures stemming from climate change, especially where there are inadequate prevention and control policies, adversely affect workers' health and safety, productive capacity and social well-being. However, variations in workers' concerns and awareness of occupational heat stress and climate change risks impede the effectiveness of heat stress management. A mixed method approach was used to assess climate change perceptions and occupational heat stress risks and adaptation strategies of Ghanaian mining workers. Read More

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December 2018

Serological and PCR-based markers of ocular Chlamydia trachomatis transmission in northern Ghana after elimination of trachoma as a public health problem.

PLoS Negl Trop Dis 2018 Dec 14;12(12):e0007027. Epub 2018 Dec 14.

Clinical Research Department, Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London, United Kingdom.

Background: Validation of elimination of trachoma as a public health problem is based on clinical indicators, using the WHO simplified grading system. Chlamydia trachomatis (Ct) infection and anti-Ct antibody responses (anti-Pgp3) have both been evaluated as alternative indicators in settings with varying levels of trachoma. There is a need to evaluate the feasibility of using tests for Ct infection and anti-Pgp3 antibodies at scale in a trachoma-endemic country and to establish the added value of the data generated for understanding transmission dynamics in the peri-elimination setting. Read More

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December 2018

Incidence, Causes, and Correlates of Maternal Near-Miss Morbidity: a multi-centre cross-sectional study.

BJOG 2018 Dec 12. Epub 2018 Dec 12.

University of Michigan, Ann Arbor, Michigan, USA.

Objective: To explore the incidence and factors associated with maternal near-miss.

Design: Cross-sectional study with an embedded case-control study.

Setting: Three tertiary referral hospitals in southern Ghana. Read More

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December 2018

Evidence of promoting prevention and the early detection of breast cancer among women, a hospital-based education and screening interventions in low- and middle-income countries: a systematic review protocol.

Syst Rev 2018 Dec 14;7(1):234. Epub 2018 Dec 14.

Discipline of Nursing, School of Nursing and Public Health, University of KwaZulu-Natal, Durban, 4001, South Africa.

Background: Given the increasing burden of breast cancer in the low- and middle-income countries, cost-effective approaches are needed to improve the early detection of breast cancer in these continents. Global policies and guidelines are now placing much emphasis on promoting early detection of breast cancer through integrated education and screening interventions. The proposed systematic review aims to map evidence on hospital-based breast cancer education, breast self-examination, and clinical breast examination services for women in low- and middle-income countries. Read More

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December 2018

Diagnostic capacity, and predictive values of rapid diagnostic tests for accurate diagnosis of Plasmodium falciparum in febrile children in Asante-Akim, Ghana.

Malar J 2018 Dec 14;17(1):468. Epub 2018 Dec 14.

Worldwide Universities Network, University of Ghana, P.O. Box LG 13, Legon, Accra, Ghana.

Background: This study seeks to compare the performance of HRP2 (First Response) and pLDH/HRP2 (Combo) RDTs for falciparum malaria against microscopy and PCR in acutely ill febrile children at presentation and follow-up.

Methods: This is an interventional study that recruited children < 5 years who reported to health facilities with a history of fever within the past 72 h or a documented axillary temperature of 37.5 °C. Read More

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December 2018

Contamination Levels and Sources of Heavy Metals and a Metalloid in Surface Soils in the Kumasi Metropolis, Ghana.

J Health Pollut 2017 Sep 7;7(15):28-39. Epub 2017 Sep 7.

Laboratory of Toxicology, Graduate School of Veterinary Medicine, Hokkaido University, Kita 18, Nishi 9, Kita ku, Sapporo 060-0818, Japan.

Background: Environmental contamination with heavy metals and metalloids due to industrial, smelting and mining activities have become common in large and growing cities. Kumasi is one of the most industrialized cities in Ghana and experiences metal pollution due to recent and past activities. Although metals are naturally abundant in the area, their accumulation in soils could potentially lead to adverse effects on local ecosystems. Read More

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September 2017

Resource Prospects of Municipal Solid Wastes Generatedin the Ga East Municipal Assembly of Ghana.

J Health Pollut 2017 Jun 22;7(14):37-47. Epub 2017 Jun 22.

Research Desk Consulting Ltd., Kwabenya-Accra, Ghana.

Background: Municipal solid wastes management has recently become an important public health concern. Municipal solid wastes are a major source of raw materials that could be used for resource recovery for diverse applications.

Objectives: The present study aimed to determine the composition of municipal solid waste and recoverable resources from the waste of the Ga East Municipal Assembly (GEMA) in the Greater Accra region of Ghana. Read More

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Biodegradation of Pollutants in Waste Water from Pharmaceutical, Textile and Local Dye Effluent in Lagos, Nigeria.

J Health Pollut 2016 Dec 19;6(12):34-42. Epub 2016 Dec 19.

Environmental Biology Unit, Department of Biological Science, Yaba College of Technology, Yaba, Lagos, Nigeria.

Background: Discharged effluents from industry have been responsible for the deterioration of the aquatic environment in many parts of the world, especially in developing countries. Increasing industrialization and urbanization have resulted in the discharge of large amounts of waste into the environment, resulting in high pollution loads. Utilization of microbes such as fungi and bacteria have been used for pollution degradation. Read More

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December 2016
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Levels of Polychlorinated Biphenyls in Plastic Resin Pellets from Six Beaches on the Accra-Tema Coastline, Ghana.

J Health Pollut 2016 Sep 13;6(11):9-17. Epub 2016 Sep 13.

School of Basic and Biomedical Sciences, University of Health and Allied Sciences, PMB 31 Ho, Volta Region, Ghana.

Background: Polychlorinated biphenyls (PCBs) are organic compounds, known to be carcinogenic and banned by the Stockholm Convention. PCBs are hydrophobic substances able to accumulate in organic materials, including plastic pellets. Plastic resin pellets are industrial raw materials that are remolded finished products for industrial and domestic use, commonly used for packaging. Read More

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September 2016

Evaluation of Heavy Metal Pollution in the Suame Industrial Area, Kumasi, Ghana.

J Health Pollut 2016 Jun 21;6(10):56-63. Epub 2016 Jun 21.

School of Basic and Biomedical Sciences, University of Health and Allied Sciences, PMB 31, Ho, Volta Region, Ghana.

Background: Heavy metal pollution in industrial and residential areas in cities has become a public health issue in Ghana. Anecdotal evidence suggests that most industrial areas have elevated levels of heavy metals in soil. As a result of poor zoning and unregulated activities, large sections of seemingly industrial areas are also used as residential areas. Read More

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Distribution and Risk Assessment of Heavy Metals in Surface Water from Pristine Environments and Major Mining Areas in Ghana.

J Health Pollut 2015 Dec 21;5(9):86-99. Epub 2015 Dec 21.

Environmental Group, Department of Chemistry, School of Physical Sciences, University of Cape Coast, Cape Coast, Ghana.

Background: Ghana, like many countries in Africa, has a history of heavy metal pollution largely emanating from industrial effluent discharges and anthropogenic deposits on prevailing winds of pollutants from industrial activities. One of the biggest contributors to pollution in the Ghanaian environment is mineral mining.

Objectives: The aim of this study was to determine the distribution and health risks of heavy metals in surface water from both pristine environments and major mining areas in Ghana. Read More

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December 2015
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Haematological parameters and lipid profile abnormalities among patients with Type-2 diabetes mellitus in Ghana.

Lipids Health Dis 2018 Dec 13;17(1):283. Epub 2018 Dec 13.

Department of Medical Laboratory Sciences, School of Biomedical and Allied Health Sciences, College of Health Sciences, University of Ghana, P. O. Box KB 143, Korle-Bu, Accra, Ghana.

Background: Diabetes mellitus is a non-infectious disease that has a high prevalence worldwide. Altered level of many haematological parameters have been observed in patients with diabetes. The levels of lipids are also affected in diabetes by many factors since carbohydrate metabolism affect lipid metabolism. Read More

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December 2018

Examining trends in inequality in the use of reproductive health care services in Ghana and Nigeria.

BMC Pregnancy Childbirth 2018 Dec 13;18(1):492. Epub 2018 Dec 13.

Department of Health Services Research, CAPHRI, Maastricht University Medical Center, Faculty of Health, Medicine and Life Sciences, Maastricht University, PO Box 616, 6200MD, Maastricht, The Netherlands.

Background: Equitable use of reproductive health care services is of critical importance since it may affect women's and children's health. Policies to reduce inequality in access to reproductive health care services are often general and frequently benefit the richer population. This is known as the inverse equity situation. Read More

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December 2018
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Experience and Future Perceived Risk of Floods and Diarrheal Disease in Urban Poor Communities in Accra, Ghana.

Int J Environ Res Public Health 2018 Dec 12;15(12). Epub 2018 Dec 12.

Regional Institute for Population Studies, University of Ghana, Legon, Accra GA521, Ghana.

Diarrheal disease is a critical health condition in urban areas of developing countries due to increasing urbanization and its associated problems of sanitation and poor access to good drinking water. Increasing floods in cities have been linked to the risk of diarrheal disease. There are few studies that specifically link flooding with diarrhea diseases. Read More

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December 2018

A shear assay study of single normal/breast cancer cell deformation and detachment from poly-di-methyl-siloxane (PDMS) surfaces.

J Mech Behav Biomed Mater 2018 Nov 15;91:76-90. Epub 2018 Nov 15.

Department of Mechanical Engineering, Worcester Polytechnic Institute (WPI), Worcester, MA 01609, USA; Department of Materials Science and Engineering, African University of Science and Technology, Km 10, Airport Road, Galadimawa, Abuja, Federal Capital Territory, Nigeria; Advanced Biotechnology Laboratory, Sheda Science and Technology Complex, Abuja, Nigeria. Electronic address:

This paper presents the results of a combined experimental and analytical/computational study of viscoelastic cell deformation and detachment from poly-di-methyl-siloxane (PDMS) surfaces. Fluid mechanics and fracture mechanics concepts are used to model the detachment of biological cells observed under shear assay conditions. The analytical and computational models are used to compute crack driving forces, which are then related to crack extension during the detachment of normal breast cells and breast cancer cells from PDMS surfaces that are relevant to biomedical implants. Read More

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November 2018

Measured energy content of frequently purchased restaurant meals: multi-country cross sectional study.

BMJ 2018 Dec 12;363:k4864. Epub 2018 Dec 12.

State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, PRC

Objective: To measure the energy content of frequently ordered meals from full service and fast food restaurants in five countries and compare values with US data.

Design: Cross sectional survey.

Setting: 223 meals from 111 randomly selected full service and fast food restaurants serving popular cuisines in Brazil, China, Finland, Ghana, and India were the primary sampling unit; 10 meals from five worksite canteens were also studied in Finland. Read More

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December 2018

Are health facilities well equipped to provide basic quality childbirth services under the free maternal health policy? Findings from rural Northern Ghana.

BMC Health Serv Res 2018 Dec 12;18(1):959. Epub 2018 Dec 12.

Faculty of Health, University of Technology Sydney, Sydney, New South Wales, Australia.

Background: Basic inputs and infrastructure including drugs, supplies, equipment, water and electricity are required for the provision of quality care. In the era of the free maternal health policy in Ghana, it is unclear if such basic inputs are readily accessible in health facilities. The study aimed to assess the availability of basic inputs including drugs, supplies, equipment and emergency transport in health facilities. Read More

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December 2018

Safety and effectiveness of antimalarial therapy in sickle cell disease: a systematic review and network meta-analysis.

BMC Infect Dis 2018 Dec 12;18(1):650. Epub 2018 Dec 12.

Centre for Tropical Clinical Pharmacology and Therapeutics, School of Medicine and Dentistry, University of Ghana, Accra, Ghana.

Background: About 80% of all reported sickle cell disease (SCD) cases in children anually are recorded in Africa. Although malaria is considered a major cause of death in SCD children, there is limited data on the safety and effectiveness of the available antimalarial drugs used for prophylaxis. Also, previous systematic reviews have not provided quantitative measures of preventive effectiveness. Read More

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December 2018
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risks due to consumption of aquaculture-produced shrimp.

Microb Risk Anal 2018 Aug 13;9:22-32. Epub 2018 Apr 13.

Department of Civil, Architectural, and Environmental Engineering, Drexel University, 3141 Chestnut Street, Philadelphia, PA 19104.

The use of aquaculture is increasing to meet the growing global demand for seafood. However, the use of aquaculture for seafood production incurs potential human health risks, especially from enteric bacteria such as spp. spp. Read More

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Characterization, Spatial Variation and Risk Assessment of Heavy Metals and a Metalloid in Surface Soils in Obuasi, Ghana.

J Health Pollut 2018 Sep 20;8(19):180902. Epub 2018 Aug 20.

Laboratory of Toxicology, Graduate School of Veterinary Medicine, Hokkaido University, Kita 18, Nishi 9, Kita ku, Sapporo 060-0818, Japan.

Background: Soil contamination with heavy metals and metalloids has become an increasingly important issue in recent years.

Objectives: The present study examines possible contamination of the environment with metals from gold mining activities in Obuasi, Ghana.

Methods: Soil samples were collected from commercial and residential areas and tailing dams in Obuasi in order to investigate the extent of lead (Pb), cadmium (Cd), mercury (Hg), copper (Cu), zinc (Zn), cobalt (Co), chromium (Cr), nickel (Ni) and arsenic (As) pollution, create thematic maps showing the extent of heavy metals pollution, identify the sources of pollution, and to assess risks to humans and the surrounding ecological system. Read More

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September 2018

Adsorption of Potentially Toxic Metals from Mono and Multi-Metal Systems Using Groundnut and Shea Nut Shell Biochars.

J Health Pollut 2018 Jun 11;8(18):180602. Epub 2018 Jun 11.

Department of Ecotourism and Environmental Management, Faculty of Natural Resources and Environment, University for Development Studies, Tamale, Ghana.

Background: Adsorption is a unique and promising method for the removal of trace metals from an aqueous environment using cost-effective and readily available biochars.

Objective: The present study examined mono and simultaneous adsorption of cadmium (Cd), mercury (Hg) and lead (Pb) onto biochars produced at pyrolysis temperatures of 350 ± 5°C and 700 ± 5°C.

Methods: Fifty mg/l of trace metal ions with 2 g/50 ml of adsorbent dosage were leached at constant room temperature of 24 ± 0. Read More

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Review of Environmental and Health Impacts of Mining in Ghana.

J Health Pollut 2018 Mar 12;8(17):43-52. Epub 2018 Mar 12.

Department of Ecotourism and Environmental Management, Faculty of Natural Resources and Environment, University for Development Studies, Nyankpala-Tamale, Ghana.

Mining has played an important role in the development of Ghana. Like all industries, mining has both benefits and risks for the people living in communities where minerals are found. How these environmental and health impacts are managed by the government, nearby communities and mining companies can either worsen or improve the lives of community inhabitants. Read More

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Microchimerism in Ghanaian children recipients of whole blood transfusion for severe anaemia.

Vox Sang 2018 Dec 6. Epub 2018 Dec 6.

Department of Haematology, University of Cambridge, Cambridge, UK.

Background And Objectives: Transfusion-acquired microchimerism (TA-Mc) has been reported in major trauma but not in young children despite relative immunodeficiency who, in sub-Saharan Africa, often suffer severe anaemia related to haemoglobinopathies or primary malaria infections. We examined the hypothesis that such massive red cell destructions might provide conditions favourable to TA-Mc, particularly when exposed to massive amounts of parasite antigens.

Materials And Methods: Twenty-seven female children <5 years transfused with male whole blood for severe anaemia (13 with acute malaria and 14 with other causes) were retrospectively identified, and a blood sample was collected >6 months post-transfusion. Read More

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December 2018

ART Denial: Results of a Home-Based Study to Validate Self-reported Antiretroviral Use in Rural South Africa.

AIDS Behav 2018 Dec 6. Epub 2018 Dec 6.

Department of Global Health and Population, Harvard T. H. Chan School of Public Health, 665 Huntington Ave, Boston, MA, 02115, USA.

There is increasing interest in home based testing and treatment of HIV to expand access to treatment in sub-Saharan Africa. Such programs rely on self-reported HIV history and use of antiretroviral therapy (ART). However, the accuracy of self-reported ART use in community settings is not well described. Read More

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December 2018

Evaluation of denaturing gradient gel electrophoresis for the detection of mycobacterial species and their potential association with waterborne pathogens.

Authors:
G Aboagye M T Rowe

J Water Health 2018 Dec;16(6):938-946

Food Microbiology Branch, Agri-Food and Biosciences Institute, Belfast, Northern Ireland, UK.

The versatility of denaturing gradient gel electrophoresis (DGGE) protocol provides enough grounds for its wide application over an array of microorganisms. This work was designed to evaluate DGGE for the detection and confirmation of mycobacteria and their association, if any, with waterborne pathogens. A total of 76 samples comprising raw untreated water, schmutzdecke, floccules and final treated water obtained from a common water source, and two water treatment works (WTW1 and WTW2), were analysed. Read More

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December 2018

The Challenges and Knowledge Gaps in Malaria Therapy: A Stakeholder Approach to Improving Oral Quinine Use in the Treatment of Childhood Malaria in Ghana.

J Pharm (Cairo) 2018 14;2018:1784645. Epub 2018 Nov 14.

Department of Pharmaceutics, Kwame Nkrumah University of Science & Technology, Kumasi, Ghana.

Background: The study was undertaken to elicit the knowledge, views, and perceptions of key stakeholders on malaria, its bioburden, and treatment options, in order to ascertain the knowledge gabs and challenges, especially in the use of oral quinine in childhood malaria.

Methods: A cross-sectional survey was conducted using a well-structured Likert Scale and self-administered questionnaire. The principal site of the study was a government-run children's hospital located in the Ashiedu Keteke Sub-Metro of Accra. Read More

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November 2018
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An overview on reproductive isolation in complex.

AoB Plants 2018 Dec 22;10(6):ply060. Epub 2018 Nov 22.

Rice Research Institute, Yunnan Agriculture University, Kunming, Yunnan, China.

Reproductive isolation is generally regarded as the essence of the speciation process. Studying closely related species is convenient for understanding the genetic basis of reproductive isolation. Therefore, the present review is restricted to the species and subspecies of the complex, which includes the two domestic rice cultivars and six wild species. Read More

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December 2018
2 Reads
1.743 Impact Factor

Highlights on the Application of Genomics and Bioinformatics in the Fight Against Infectious Diseases: Challenges and Opportunities in Africa.

Front Genet 2018 27;9:575. Epub 2018 Nov 27.

West African Centre for Cell Biology of Infectious Pathogens, University of Ghana, Accra, Ghana.

Genomics and bioinformatics are increasingly contributing to our understanding of infectious diseases caused by bacterial pathogens such as and parasites such as . This ranges from investigations of disease outbreaks and pathogenesis, host and pathogen genomic variation, and host immune evasion mechanisms to identification of potential diagnostic markers and vaccine targets. High throughput genomics data generated from pathogens and animal models can be combined with host genomics and patients' health records to give advice on treatment options as well as potential drug and vaccine interactions. Read More

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November 2018

Malaria causes long-term effects on markers of iron status in children: a critical assessment of existing clinical and epidemiological tools.

Malar J 2018 Dec 11;17(1):464. Epub 2018 Dec 11.

Centre for Medical Parasitology, Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

Background: Most epidemiological studies on the interplay between iron deficiency and malaria risk classify individuals as iron-deficient or iron-replete based on inflammation-dependent iron markers and adjustment for inflammation by using C-reactive protein (CRP) or α-1-acid glycoprotein (AGP). The validity of this approach and the usefulness of fibroblast growth factor 23 (FGF23) as a proposed inflammation-independent iron marker were tested.

Methods: Conventional iron markers and FGF23 were measured in children with acute falciparum malaria and after 1, 2, 4, and 6 weeks. Read More

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December 2018
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Novel strains in malaria vectors from Sub-Saharan Africa.

Wellcome Open Res 2018 27;3:113. Epub 2018 Nov 27.

Department of Disease Control, London School of Hygiene & Tropical Medicine, London, WC1E 7HT, UK.

, a common insect endosymbiotic bacterium that can influence pathogen transmission and manipulate host reproduction, has historically been considered absent from the  genera, but has recently been found in  s.l. populations in West Africa. Read More

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November 2018
2 Reads

How does 'Becoming Breastfeeding Friendly' work? A Program Impact Pathways analysis.

Matern Child Nutr 2018 Dec 7:e12766. Epub 2018 Dec 7.

Yale School of Public Health, New Haven, CT, USA.

Becoming Breastfeeding Friendly (BBF) is an initiative designed to track country readiness and progress to effectively scale up breastfeeding programs. BBF includes a policy toolbox that has three components: the Becoming Breastfeeding Friendly Index (BBFI), case studies, and a 5-meeting process. Mapping pathways of how BBF was implemented and utilized enables contextually grounded interpretation of its impact on breastfeeding outcomes. Read More

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December 2018
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Health insurance and social capital in Ghana: a cluster randomised controlled trial.

Glob Health Res Policy 2018 6;3:35. Epub 2018 Dec 6.

6Cardiff University, Cardiff, CF10 3AT Wales, UK.

Background: The National Health Insurance Scheme (NHIS) was introduced in Ghana in 2003, enrolment is still far from the desired target of universal coverage. Low community engagement in the design and management of the system was identified as one of the main barriers. The aim of the current study was to explore the role of social capital in NHIS enrolment in two regions of Ghana, Western and Greater Accra. Read More

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December 2018
2 Reads

Respiratory failure requiring mechanical ventilation in critically ill adults in Ghana: A prospective observational study.

Afr J Emerg Med 2018 Dec 20;8(4):155-157. Epub 2018 Sep 20.

Department of Emergency Medicine, University of Florida, Gainesville, FL, USA.

Introduction: Respiratory failure is commonly seen in African emergency centres and intensive care units, but little is known about the need for intubation and mechanical ventilation.

Methods: From April to October 2017, we recorded the number of patients intubated and ventilated in the emergency centre and intensive care unit at Komfo Anokye Teaching Hospital in Kumasi, Ghana on a daily basis. We assessed patients for presence of acute respiratory distress syndrome (ARDS) using the Kigali Modification of the Berlin ARDS criteria. Read More

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December 2018

Experiences and perceptions of the theory-practice gap in nursing in a resource-constrained setting: A qualitative description study.

Nurs Open 2019 Jan 19;6(1):72-83. Epub 2018 Jul 19.

Department of Mental Health, School of Nursing and Midwifery, College of Health and Allied Sciences University of Cape Coast Cape Coast Ghana.

Aim: To describe experiences and perceptions of theory-practice gap in nursing in a resource-constrained setting. Theory-practice gap is extensively discussed and studied in some parts of the world. Interventions to bridge the theory-practice gap have been varied and depend on an understanding of the contextual healthcare environment. Read More

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January 2019

Genetic diversity of hepatitis viruses in West-African countries from 1996 to 2018.

World J Hepatol 2018 Nov;10(11):807-821

Biochemistry-Microbiology, CERBA/LABIOGENE, Ouagadougou 02006, Burkina Faso.

The severity of hepatic pathology and the response to treatment depend on the hepatitis virus genotype in the infected host. The objective of this review was to determine the distribution of hepatitis virus genotypes in West African countries. A systematic review of the literature in PubMed, Google Scholar and Science Direct was performed to identify 52 relevant articles reporting hepatitis A, B, C, D, E and G viruses genotypes. Read More

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November 2018

Meta-narrative review of molecular methods for diagnosis and monitoring of multidrug-resistant tuberculosis treatment in adults.

Int J Mycobacteriol 2018 Oct-Dec;7(4):299-309

Kibong'oto Infectious Diseases Hospital, Sanya Juu, Siha, Kilimanjaro; Department of Global Health and Biomedical Sciences, School of Life Science and Bioengineering, Nelson Mandela-African Institution for Science and Technology, Arusha, Tanzania.

Early and accurate diagnosis and rigorous clinical and microbiological monitoring of multidrug-resistant tuberculosis (MDR-TB) treatment can curb morbidity and mortality. While others are still under evaluation, the World Health Organization has recommended few novel molecular methods for MDR-TB diagnosis only. We present current molecular methods for diagnosis and monitoring of MDR-TB treatment in TB-endemic settings. Read More

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December 2018

Usual adult occupation and risk of prostate cancer in West African men: the Ghana Prostate Study.

Occup Environ Med 2018 Dec 7. Epub 2018 Dec 7.

Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA.

Objectives: Established prostate cancer (PCa) risk factors include age, family history of PCa and African ancestry. Studies, mostly among highly screened, predominantly European ancestral populations, suggest that employment in certain occupations (eg, farming, military) may also have an increased risk for PCa. Here, we evaluated the association between usual adult occupation and PCa risk in Ghanaian men, a population with historically low rates of PCa screening. Read More

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December 2018

Case for equity between Paris Climate agreement's Co-benefits and adaptation.

Sci Total Environ 2018 Nov 23;656:732-739. Epub 2018 Nov 23.

Regional Institute for Population Studies, University of Ghana, Legon, Ghana; Climate Change Working Group, University of Ghana, Legon, Ghana; School of Animal, Plant and Environmental Sciences, University of the Witwatersrand, Johannesburg, South Africa. Electronic address:

There are heightened debates on limited opportunity of the global adaptation policy goals of the Paris Climate Agreement (PaCA) to match efforts at mitigation and adaptation. This has been attributed partially to the overstatement in Article 7 Paragraph 4 of the PaCA that "greater levels of mitigation" reduces the cost of additional adaptation through mitigation Co-benefits. Therefore, the paper explores how Article 7 of the PaCA partially faults the natural synergy between mitigation and adaptation to equally reduce aggregate emission, although mitigation could help reduce adaptation to physical exposure. Read More

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November 2018

Temporal Trends of Pediatric Hospitalizations with Acute Disseminated Encephalomyelitis in the United States: An Analysis from 2006 to 2014 using National Inpatient Sample.

J Pediatr 2018 Dec 6. Epub 2018 Dec 6.

Department of Pediatrics, Tulane University, New Orleans, LA; Department of Pediatrics, Texas Tech University Health Sciences Center, Amarillo, TX.

Objective: To determine the temporal trends in the epidemiology of acute disseminated encephalomyelitis (ADEM) and hospitalization outcomes in the US from 2006 through 2014.

Study Design: Pediatric (≤18 years of age) hospitalizations with ADEM discharge diagnosis were identified from the National (Nationwide) Inpatient Sample (NIS) for years 2006 through 2014. Trends in the incidence of ADEM with respect to age, sex, race, and region were examined. Read More

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December 2018

Global patterns of mortality in international migrants: a systematic review and meta-analysis.

Lancet 2018 Dec 5. Epub 2018 Dec 5.

Institute for Global Health, University College London, London, UK.

Background: 258 million people reside outside their country of birth; however, to date no global systematic reviews or meta-analyses of mortality data for these international migrants have been done. We aimed to review and synthesise available mortality data on international migrants.

Methods: In this systematic review and meta-analysis, we searched MEDLINE, Embase, the Cochrane Library, and Google Scholar databases for observational studies, systematic reviews, and randomised controlled trials published between Jan 1, 2001, and March 31, 2017, without language restrictions. Read More

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December 2018
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Loop-mediated isothermal amplification-based detection of typhoid fever on an automated Genie II Mk2 system - A case-control-based approach.

Acta Trop 2018 Dec 5;190:293-295. Epub 2018 Dec 5.

Infectious Diseases Epidemiology, Bernhard-Nocht Institute for Tropical Medicine Hamburg, Bernhard-Nocht-Str. 74, 20359, Hamburg, Germany; German Center for Infection Research (DZIF), Hamburg-Borstel-Lübeck, Germany.

Typhoid fever, caused by the bacterium Salmonella enterica subsp. enterica serovar Typhi, is an important cause of blood stream infections in the tropics, for which easy-to-apply molecular diagnostic approaches are desirable. The diagnostic performance of a newly introduced and a previously described loop-mediated isothermal amplification (LAMP) approach using different primer sets on a Genie II Mk2 device for the identification of Salmonella enterica ssp. Read More

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December 2018

Young maternal age is a risk factor for child undernutrition in Tamale Metropolis, Ghana.

BMC Res Notes 2018 Dec 10;11(1):877. Epub 2018 Dec 10.

Department of Nutritional Sciences, School of Allied Health Sciences, University for Development Studies, P O Box TL 1883, Tamale, Ghana.

Objective: Malnutrition is a common cause of morbidity and mortality in children. The aim of this study was to compare the nutritional status of children under 5 years of teenage and adult mothers in Tamale Metropolis, Ghana. A case-control study involving 300 (150 cases, 150 controls) mother-child pairs was carried out. Read More

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December 2018

Religion and Health: exploration of attitudes and health perceptions of faith healing users in urban Ghana.

BMC Public Health 2018 Dec 10;18(1):1358. Epub 2018 Dec 10.

Department of Geography and Rural Development, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.

Background: The main aim of the study was to explore the attitudes and health perceptions of faith healing users in Kumasi Metropolis, Ghana. This has become necessary because faith healing practice is an important area but remains neglected in the health care literature. In an age when biowestern medicine is touted as the cure for most diseases, understanding how and why individuals seek alternative treatment, specifically faith healing modalities may help to develop more effective health care interventions. Read More

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December 2018

Schizont transcriptome variation among clinical isolates and laboratory-adapted clones of the malaria parasite Plasmodium falciparum.

BMC Genomics 2018 Dec 10;19(1):894. Epub 2018 Dec 10.

Pathogen Molecular Biology Department, London School of Hygiene and Tropical Medicine, London, UK.

Background: Malaria parasites are genetically polymorphic and phenotypically plastic. In studying transcriptome variation among parasites from different infections, it is challenging to overcome potentially confounding technical and biological variation between samples. We investigate variation in the major human parasite Plasmodium falciparum, generating RNA-seq data on multiple independent replicate sample preparations of merozoite-containing intra-erythrocytic schizonts from a panel of clinical isolates and from long-term laboratory-adapted clones, with a goal of robustly identifying differentially expressed genes. Read More

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December 2018
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The impact of patient feedback on clinical practice.

Br J Hosp Med (Lond) 2018 Dec;79(12):700-703

Senior Health Services Administrator, Department of Administration, Kwesimintsim Government Hospital, Takoradi, Western Region, Ghana.

Feedback from patients about the care they have received is an integral part of quality in health care. This article looks at the extent to which patient feedback impacts the performance of clinicians and provision of clinical care. A non-systematic literature search was conducted in a narrative form on five electronic databases, including English language peer-reviewed articles published within the last 18 years. Read More

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December 2018