6,783 results match your criteria Gestational Trophoblastic Neoplasia


Evaluation of High-Dose Vitamin A Treatment in Postmolar Patients with Low and Plateauing Serum Human Chorionic Gonadotropin Levels.

Rev Bras Ginecol Obstet 2020 May 29;42(5):240-247. Epub 2020 May 29.

Rio de Janeiro Gestational Trophoblastic Disease Reference Center, Department of Obstetrics and Gynecology, Maternity School, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.

Objective:  To compare the effect of high-dose vitamin A (HD Vit-A) use during postmolar follow-up of patients with low and plateauing (L&P) serum human chorionic gonadotropin (hCG) levels, from the moment serum hCG plateaued (P-hCG) to the first normal serum hCG value (< 5 IU/L).

Methods:  The present retrospective series case study compared two nonconcurrent cohorts of patients. Control group (CG): 34 patients with L&P serum hCG levels who underwent expectant management for 6 months after uterine evacuation, from 1992 to 2010; study group (SG): 32 patients in similar conditions who received 200,000 IU of Vit-A daily, from the identification of a P-hCG level to the first normal hCG value or the diagnosis of progression to gestational trophoblastic neoplasia (GTN), from 2011 to 2017. Read More

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http://dx.doi.org/10.1055/s-0040-1710302DOI Listing

Usefulness of methylation-specific multiplex ligation-dependent probe amplification for identification of parental origin of triploidy.

J Hum Genet 2020 Jun 1. Epub 2020 Jun 1.

Department of Genetics, Institute of Psychiatry and Neurology, Sobieskiego 9, 02-957, Warsaw, Poland.

Triploidy is a genetic aberration resulting from an extra haploid set of chromosomes of paternal (diandric) or maternal (digynic) origin. Diandric cases, opposite to digynic ones, may lead to gestational trophoblastic neoplasia (GTN) or generate maternal complications, therefore their identification is crucial, but reproducibility of traditionally used histopathological assessment is poor. The aim of the study was to analyse the usefulness of methylation-specific multiplex ligation-dependent probe amplification (MS-MLPA) with probes for two differentially methylated regions (DMR) at chromosome 11p. Read More

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http://dx.doi.org/10.1038/s10038-020-0784-0DOI Listing

How to optimize the management of gestational trophoblastic disease during the COVID era?

Am J Obstet Gynecol 2020 May 28. Epub 2020 May 28.

New England Trophoblastic Disease Center, Division of Gynecologic Oncology, Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women's Hospital, Harvard Medical School, Boston - MA, USA.

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http://dx.doi.org/10.1016/j.ajog.2020.05.042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7256512PMC

An international randomized phase III trial of pulse actinomycin-D versus multi-day methotrexate for the treatment of low risk gestational trophoblastic neoplasia; NRG/GOG 275.

Gynecol Oncol 2020 May 24. Epub 2020 May 24.

University of Texas Southwestern Medical Center, Dallas, TX, USA. Electronic address:

Objectives: Methotrexate and actinomycin-D are both effective first-line drugs for low-risk (WHO score 0-6) Gestational Trophoblastic Neoplasia (GTN) with considerable debate about which is more effective, less toxic, and better tolerated. The primary trial objective was to test if treatment with multi-day methotrexate (MTX) was inferior to pulse actinomycin-D (ACT-D). Secondary objectives included evaluation of severity and frequency of adverse events, and impact on quality of life (QOL). Read More

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http://dx.doi.org/10.1016/j.ygyno.2020.05.013DOI Listing

Hemoptysis as the first symptom in the diagnosis of metastatic choriocarcinoma in the third trimester of pregnancy: A case report.

Case Rep Womens Health 2020 Jul 28;27:e00211. Epub 2020 Apr 28.

Department of Obstetrics, Miguel Servet Maternal University Hospital, Paseo Isabel la Católica, 1-3, 50009 Zaragoza, Spain.

Introduction: Choriocarcinoma is a rare neoplasm (1/40000 pregnancies). In the context of a viable pregnancy, the incidence is even lower (1/160000).

Case Report: A woman in her second pregnancy was admitted at 31 + 6 weeks of gestation with hemoptysis and abnormal vaginal bleeding. Read More

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http://dx.doi.org/10.1016/j.crwh.2020.e00211DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7226679PMC

Intraplacental choriocarcinoma and fetomaternal haemorrhage and maternal disseminated intravascular coagulopathy in a term pregnancy: A case report.

Case Rep Womens Health 2020 Jul 6;27:e00216. Epub 2020 May 6.

Hornsby Kuringai Hospital, Northern Sydney Local Health District, Sydney, Australia.

Background: Intraplacental choriocarcinoma (ICC) is a rare form of gestational trophoblastic disease that has been documented as complicating near-term pregnancies with massive fetomaternal haemorrhage (FMH), intrauterine fetal demise, neonatal anaemia, and disseminated disease of both mother and child.

Case: A 31-year-old woman at 38 weeks of gestation underwent caesarean section due to reduced fetal movements. The caesarean section was complicated by disseminated intravascular coagulopathy (DIC). Read More

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http://dx.doi.org/10.1016/j.crwh.2020.e00216DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7218156PMC

Quantitative Proteomic Profiling Identifies SOX8 as Novel Regulator of Drug Resistance in Gestational Trophoblastic Neoplasia.

Front Oncol 2020 28;10:557. Epub 2020 Apr 28.

Department of Gynecology and Obstetrics, Xiangya Hospital, Central South University, Changsha, China.

The development of drug resistance remains one of the major challenges to current chemotherapeutic regimens in gestational trophoblastic neoplasia (GTN). Further understanding on the mechanisms of drug resistance would help to develop more effective therapy to treat GTN. Herein, tandem mass tag-based (TMT) quantitative proteomic technique was used to establish drug resistance-related proteomic profiles in chemoresistant GTN cell models (JEG3/MTX, JEG3/VP16, JEG3/5-Fu). Read More

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http://dx.doi.org/10.3389/fonc.2020.00557DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7198745PMC

Heterozygous/dispermic complete mole confers a significantly higher risk for post-molar gestational trophoblastic disease.

Mod Pathol 2020 May 13. Epub 2020 May 13.

Department of Pathology, Yale University School of Medicine, New Haven, CT, USA.

Hydatidiform moles are classified at the genetic level as androgenetic complete mole and diandric-monogynic partial mole. Conflicting data exist whether heterozygous complete moles are more aggressive clinically than homozygous complete moles. We investigated clinical outcome in a large cohort of hydatidiform moles in Chinese patients with an emphasis on genotypical correlation with post-molar gestational trophoblastic disease. Read More

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http://dx.doi.org/10.1038/s41379-020-0566-4DOI Listing

EMA vs EMACO in the treatment of gestational trophoblastic neoplasia.

Gynecol Oncol 2020 May 11. Epub 2020 May 11.

Division of Gynecologic Oncology, Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States; Dana-Farber Cancer Institute, Boston, MA, United States; New England Trophoblastic Disease Center, Boston, MA, United States. Electronic address:

Objective: To compare experiences with EMA versus EMACO in the treatment of gestational trophoblastic neoplasia.

Methods: The medical records of women diagnosed with GTN at the New England Trophoblastic Disease Center from 1986 to 2019 were reviewed, and women receiving EMA or EMACO as their first multiagent regimen were eligible. Clinical characteristics, treatment, outcomes, and adverse events were compared between the two groups. Read More

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http://dx.doi.org/10.1016/j.ygyno.2020.04.699DOI Listing

Gestational trophoblastic neoplasia lethality among Brazilian women: A retrospective national cohort study.

Gynecol Oncol 2020 May 8. Epub 2020 May 8.

New England Trophoblastic Disease Center, Division of Gynecologic Oncology, Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

Objective: To investigate GTN lethality among Brazilian women comparing cases of death by GTN with those who survived, thereby identifying factors associated with GTN lethality.

Methods: We retrospectively reviewed medical records of women with GTN treated at ten Brazilian GTN Reference Centers, from January 1960 to December 2017. We evaluated factors associated with death from GTN and used Cox proportional hazards regression models to identify independent variables with significant influence on the risk of death. Read More

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http://dx.doi.org/10.1016/j.ygyno.2020.04.704DOI Listing

A case of multi-agent drug resistant choriocarcinoma treated with Pembrolizumab.

Gynecol Oncol Rep 2020 May 23;32:100574. Epub 2020 Apr 23.

Division of Gynecologic Surgery, Department of Obstetrics and Gynecology, Mayo Clinic, Rochester, MN, USA.

•High-risk multi-agent drug resistant GTN is a life threatening disease.•Majority of choriocarcinomas show intense PD-L1 immunoreactivity.•Pembrolizumab increases antitumor activity. Read More

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http://dx.doi.org/10.1016/j.gore.2020.100574DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7210394PMC

p57-discordant villi in hydropic products of conception: a clinicopathological study of 70 cases.

Hum Pathol 2020 May 5. Epub 2020 May 5.

Department of Pathology, Lyon Sud University Hospital, Hospices Civils de Lyon, Pierre Bénite, Lyon, 69495, France; French Reference Center for Gestational Trophoblastic Diseases, Lyon Sud University Hospital, Hospices Civils de Lyon, Pierre-Bénite, 69495, France. Electronic address:

p57 immunostaining is performed on hydropic products of conception to diagnose hydatidiform moles (HMs), which can progress to gestational trophoblastic neoplasia. Partial hydatidiform mole (PHM) and hydropic abortion (HA) display positive staining in stromal and cytotrophoblastic cells, whereas complete hydatidiform mole (CHM) is characterized by loss of p57 expression in both cell types. In some cases, an aberrant pattern is observed, called discordant p57 expression, with positive cytotrophoblast staining and negative stromal staining, or vice versa. Read More

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http://dx.doi.org/10.1016/j.humpath.2020.04.011DOI Listing

Doppler-based predictive model for methotrexate resistance in low-risk gestational trophoblastic neoplasia with myometrial invasion: prospective study with 147 Patients.

Ultrasound Obstet Gynecol 2020 May 8. Epub 2020 May 8.

Women's Reproductive Health Key Laboratory of Zhejiang Province, Women's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.

Objectives: This prospective clinical study aimed to evaluate the vascularization characteristics of low-risk gestational trophoblastic neoplasia (GTN) using Doppler imaging and to develop a predictive model of resistance to methotrexate (MTX).

Methods: Patients with low-risk GTN receiving primary MTX treatment were enrolled from the Women's Hospital, Zhejiang University School of Medicine, from September 2012 to August 2018. In the training set, clinical features and hemodynamic parameters with Doppler imaging before MTX therapy were analyzed by logistic regression for identifying the independent predictors, which were integrated into the model. Read More

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http://dx.doi.org/10.1002/uog.22069DOI Listing

Outcomes in the management of high-risk gestational trophoblastic neoplasia in trophoblastic disease centers in South America.

Int J Gynecol Cancer 2020 May 5. Epub 2020 May 5.

Division of Gynecologic Oncology, Department of Obstetrics, Gynecology and Reproductive Biology, New England Trophoblastic Disease Center, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.

Background: South America has a higher incidence of gestational trophoblastic disease than North America or Europe, but whether this impacts chemotherapy outcomes is unclear. The purpose of this study was to evaluate outcomes among women with high-risk gestational trophoblastic neoplasia (GTN) treated at trophoblastic disease centers in developing South American countries.

Methods: This retrospective cohort study included patients with high-risk GTN treated in three trophoblastic disease centers in South America (Botucatu and Rio de Janeiro, Brazil, and Buenos Aires, Argentina) from January 1990 to December 2014. Read More

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http://dx.doi.org/10.1136/ijgc-2020-001237DOI Listing

Adenomyosis presenting as a molar pregnancy: A case report.

Gynecol Oncol Rep 2020 May 23;32:100573. Epub 2020 Apr 23.

Division of Gynecologic Oncology, Washington University School of Medicine, St. Louis, MO, USA.

•We present a case of atypical adenomyosis with clinical, laboratory, and imaging findings suggestive of a molar pregnancy.•Adenomyosis causes uterine enlargement and may appear cystic on vaginal ultrasound.•Falsely elevated β-hCG in the setting of obesity and hypothyroidism may complicate diagnosing abnormal uterine bleeding. Read More

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http://dx.doi.org/10.1016/j.gore.2020.100573DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7191572PMC

Obstetric outcomes of twin pregnancies presenting with a complete hydatidiform mole and coexistent normal fetus: a systematic review and meta-analysis.

BJOG 2020 Apr 27. Epub 2020 Apr 27.

Faculty of Population Health Sciences, EGA Institute for Women's Health, University College London, London, UK.

Background: Epidemiological data on obstetric and oncologic complications in twin pregnancies combining a complete hydatidiform mole (CHM) coexisting with a normal fetus and placenta are limited.

Objectives: To evaluate perinatal and obstetric outcomes for mother and fetus and risk of gestational trophoblastic neoplasia (GTN) in twin pregnancies including a CHM.

Search Strategy: PubMed, MEDLINE and EMBASE and the grey literature were searched for articles published between May 1980 and May 2019 using a protocol designed a priori and registered on PROSPERO (CRD42018112524). Read More

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http://dx.doi.org/10.1111/1471-0528.16283DOI Listing

Gestational Trophoblastic Neoplasia After Human Chorionic Gonadotropin Normalization Following Molar Pregnancy: A Systematic Review and Meta-analysis.

Obstet Gynecol 2020 May;135(5):1226

Touro University California, Vallejo, California University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.

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http://dx.doi.org/10.1097/AOG.0000000000003847DOI Listing

Gestational Trophoblastic Neoplasia After Human Chorionic Gonadotropin Normalization Following Molar Pregnancy: A Systematic Review and Meta-Analysis.

Obstet Gynecol 2020 May;135(5):1225-1226

Department of Obstetrics and Gynecology, University of Florida College of Medicine, Jacksonville, Florida.

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http://dx.doi.org/10.1097/AOG.0000000000003846DOI Listing

Pitfalls in the assessment of gestational transient thyrotoxicosis.

Authors:
Shigeo Iijima

Gynecol Endocrinol 2020 Apr 17:1-6. Epub 2020 Apr 17.

Department of Regional Neonatal-Perinatal Medicine, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, Japan.

Gestational transient thyrotoxicosis (GTT) is associated with direct stimulation of the maternal thyroid gland by human chorionic gonadotropin (hCG). It is characterized by slightly higher thyroid hormone and lower thyroid-stimulating hormone (TSH) levels in early pregnancy and mild or no symptoms. While GTT must be distinguished from Graves' disease (GD), which is associated with maternal and fetal complications, treated GD and new-onset GD in pregnancy are occasionally challenging to distinguish. Read More

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http://dx.doi.org/10.1080/09513590.2020.1754391DOI Listing

Roles of Medicinal Plants and Constituents in Gynecological Cancer Therapy: Current Literature and Future Directions.

Curr Top Med Chem 2020 Apr 15. Epub 2020 Apr 15.

Department of Pharmacy, Abdul Wali Khan University, Mardan, 23200. Pakistan.

Gynecologic cancers, including cervical, primary peritoneal, ovarian, uterine/endometrial, vaginal and vulvar cancers and gestational trophoblastic disease, are characterized by abnormal cell proliferation in female reproductive cells. Due to the variable pathology of these cancers and the lack of appropriate screening tests in developing countries, cancer diagnosis can be reported in advanced stages in most women and this situation adversely affects prognosis and clinical outcomes of illness. For this reason, many researchers in the field of gynecological oncology have carried out many studies. Read More

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http://dx.doi.org/10.2174/1568026620666200416084440DOI Listing

Cost-effectiveness of second curettage for treatment of low-risk non-metastatic gestational trophoblastic neoplasia.

Gynecol Oncol 2020 Apr 7. Epub 2020 Apr 7.

Oregon Health & Sciences University, Portland, OR, United States. Electronic address:

Objective: Low-risk non-metastatic gestational trophoblastic neoplasia (GTN) has been treated with single agent chemotherapy, but second curettage is emerging as an alternative strategy with reported cure rates of 40%. We sought to estimate the cost-effectiveness of second curettage as the first line treatment of low-risk GTN.

Methods: A decision-analytic model was created using TreeAge software to compare costs and outcomes for women with WHO staged low-risk GTN undergoing treatment with 5-day methotrexate (MTX), biweekly pulsed actinomycin-D, or second curettage. Read More

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http://dx.doi.org/10.1016/j.ygyno.2020.03.029DOI Listing

Placental site trophoblastic tumor: Successful treatment of 13 cases.

Gynecol Oncol Rep 2020 May 13;32:100548. Epub 2020 Feb 13.

John I. Brewer Trophoblastic Disease Center, Division of Gynecologic Oncology, Department of Obstetrics & Gynecology, Northwestern University Feinberg School of Medicine Chicago, IL, USA.

Placental site trophoblastic tumor (PSTT) is a rare variant of gestational trophoblastic neoplasia (GTN) that is characterized by slow growth resulting in mostly uterine-confined disease, low human chorionic gonadotropin (hCG) levels, and resistance to chemotherapy. Our objective was to update our center's experience with PSTT with respect to presentation, prognostic factors, treatment, and outcomes from 2003 to 2019. Thirteen women with PSTT were identified. Read More

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http://dx.doi.org/10.1016/j.gore.2020.100548DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7132153PMC

Practical clinical guidelines of the EOTTD for treatment and referral of gestational trophoblastic disease.

Eur J Cancer 2020 May 1;130:228-240. Epub 2020 Apr 1.

Charing Cross Gestational Trophoblastic Disease Centre, Charing Cross Hospital, Imperial College London, London, UK. Electronic address:

Background And Aim: Gestational trophoblastic disease (GTD) is a heterogeneous group of disorders characterised by abnormal proliferation of trophoblastic tissue. Since GTD and its malignant sequel gestational trophoblastic neoplasia (GTN) are rare diseases, little evidence is available from randomised controlled trials on optimal treatment and follow-up. Treatment protocols vary within Europe, and even between different centres within countries. Read More

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http://dx.doi.org/10.1016/j.ejca.2020.02.011DOI Listing

Successful Management of the First Case of a Metastasized Complete Mole in Form of Twin Pregnancy in Jordan.

Am J Case Rep 2020 Apr 1;21:e923395. Epub 2020 Apr 1.

Department of Obstetrics and Gynecology, Faculty of Medicine, Yarmouk University, Irbid, Jordan.

BACKGROUND A complete mole with a living fetus in a form of twin pregnancy that is a rare obstetric event. The development of metastatic gestational trophoblastic disease is the most important and serious complication. It is debatable whether to terminate the pregnancy or to continue. Read More

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http://dx.doi.org/10.12659/AJCR.923395DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7162559PMC

The potential of serum fetal DNA for early diagnosis of gestational trophoblastic disease.

Turk J Obstet Gynecol 2019 Dec 28;16(4):249-254. Epub 2020 Feb 28.

Private Practise, Clinic of Obstetrics and Gynecology, Gaziantep, Turkey.

Objective: To study cell-free DNA (cfDNA) levels in patients with gestational trophoblastic disease (GTD) in order to test the hypothesis that cfDNA circulating in maternal plasma could provide early detection of GTD.

Materials And Methods: This study included 32 patients with GTD (complete mole and partial mole) and 30 non-GTD patients in the first trimester of pregnancy with no other medical problems. cfDNA levels in maternal serum were measured using polymerase chain reaction analysis on Y-chromosome-specific sequences. Read More

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http://dx.doi.org/10.4274/tjod.galenos.2019.54815DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7090260PMC
December 2019

Maternal complications in molecularly confirmed diandric and digynic triploid pregnancies: single institution experience and literature review.

Arch Gynecol Obstet 2020 May 26;301(5):1139-1145. Epub 2020 Mar 26.

Department of Gynecologic Oncology and Obstetrics, Centre of Postgraduate Medical Education, Czerniakowska 231, 00-416, Warsaw, Poland.

Objectives: Assessment of the maternal complications in molecularly confirmed diandric and digynic triploid pregnancies.

Methods: Sonographic features, biochemical results, and clinical presentation were analyzed. Beta-hCG level was controlled after diandric triploidy. Read More

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http://dx.doi.org/10.1007/s00404-020-05515-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7181501PMC

Recurrent Molar in Five Consecutive Pregnancies - A Case Report.

Int J Womens Health 2020 9;12:171-174. Epub 2020 Mar 9.

Lucknow Cancer Institute, Lucknow, India.

Recurrent molar pregnancy is very rare. In this case report, we highlight a case of a patient who experienced five recurrent molar pregnancies without an intervening normal pregnancy. A 22-year-old patient was admitted to our labour room with a fifth consecutive molar pregnancy. Read More

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http://dx.doi.org/10.2147/IJWH.S230417DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7071727PMC

Prevalence of Partial Hydatidiform Mole in Products of Conception From Gestations With Fetal Triploidy Merits Reflex Genotype Testing Independent of the Morphologic Appearance of the Chorionic Villi.

Am J Surg Pathol 2020 Jun;44(6):849-858

Departments of Pathology.

Diagnosis of first-trimester partial mole is challenging as the key morphologic features may not be well-developed and may overlap with those of a nonmolar gestation harboring a cytogenetic disorder or degenerative changes. Genotype testing has emerged as the reference tool to distinguish partial mole (diandric triploid genotype) from its nonmolar mimics. However, observer variation in defining the minimum threshold of how much morphologic alteration is required to trigger genotype testing may result in a subset of partial moles that go undetected. Read More

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http://dx.doi.org/10.1097/PAS.0000000000001466DOI Listing

ABO blood type compatibility is not a risk factor for gestational trophoblastic neoplasia development from androgenetic complete hydatidiform moles.

Am J Reprod Immunol 2020 Jun 8;83(6):e13237. Epub 2020 Apr 8.

Department of Reproductive Medicine, Graduate School of Medicine, Chiba University, Chiba, Japan.

Problem: Complete hydatidiform moles (CHMs) are allografts to patients in terms of an androgenetic origin. Thus, some immunological reactions may be involved in the development of gestational trophoblastic neoplasia (GTN) from CHMs. This study aimed to evaluate the effect of ABO blood group on the prognosis of androgenetic CHMs. Read More

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http://dx.doi.org/10.1111/aji.13237DOI Listing

Head-to-head comparison of [F]-fluorodeoxyglucose and [F]-fluorocholine positron emission tomography/computed tomography in three patients with rare gestational trophoblastic neoplasms: A case series.

World J Nucl Med 2020 Jan-Mar;19(1):72-77. Epub 2019 Jul 23.

Department of Neurosurgery, Oncology, OBGYN, Biomedical Engineering, School of Medicine, College of Engineering, and Karmanos Cancer Institute, Wayne State University, Detroit, Michigan, USA.

We report the efficacy of dual positron emission tomography/computed tomography (PET/CT) imaging with [F]-2'-fluoro-2'-deoxy-D-glucose ([F]-FDG) and [F]-fluorocholine ([F]-FCH) in patients with gestational trophoblastic neoplasia (GTN) for primary diagnosis and staging of this rare pregnancy-related disorder. Whole-body PET/CT with [F]-FDG and [F]-FCH was performed in three patients with GTN in 2 consecutive days. Each detectable lesion was characterized by visual and quantitative analyses. Read More

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http://dx.doi.org/10.4103/wjnm.WJNM_91_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7067124PMC

Differential expression of SALL4 in CTCs derived from hydatidiform moles and gestational trophoblastic neoplasms.

Am J Reprod Immunol 2020 May 16;83(5):e13233. Epub 2020 Apr 16.

State Key Laboratory of Molecular Oncology, Department of Clinical Laboratory, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Problem: To investigate EMT phenotype and SALL4 expression of circulating tumour cells (CTCs) in patients with gestational trophoblastic neoplasm (GTN).

Method Of Study: CanPatrol CTC detection system in combination with SALL4 RNA in situ hybridization was used to investigate the profile of CTCs in different types of gestational trophoblastic disease (GTD). Circulating CTCs were phenotyped and annotated with SALL4 expression in 41 GTD patients, including 12 HM and 29 GTN, as well as 22 pregnant volunteers. Read More

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http://dx.doi.org/10.1111/aji.13233DOI Listing
May 2020
2.438 Impact Factor

[Epithelioid trophoblastic tumour with pulmonary metastasis].

Rev Med Liege 2020 Mar;75(3):145-150

Service de Pneumologie, CHR Verviers, Belgique.

Epithelioid trophoblastic tumours are rare kind of gestational trophoblastic disease. Their detection is made by repetitive measurement of ?HCG after any gestational period (including spontaneous abortion). Epithelioid trophoblastic tumour can cause pulmonary metastasis. Read More

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Demographics, natural history and treatment outcomes of non-molar gestational choriocarcinoma: a UK population study.

BJOG 2020 Mar 7. Epub 2020 Mar 7.

Department of Medical Oncology, Trophoblastic Tumour Screening and Treatment Centre, Charing Cross Hospital, Imperial Hospitals NHS Trust, London, UK.

Objective: To investigate the demographics, natural history and treatment outcomes of non-molar gestational choriocarcinoma.

Design: A retrospective national population-based study.

Setting: UK 1995-2015. Read More

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http://dx.doi.org/10.1111/1471-0528.16202DOI Listing

Evaluation of a routine second curettage for hydatidiform mole: a cohort study.

Int J Clin Oncol 2020 Jun 6;25(6):1178-1186. Epub 2020 Mar 6.

Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, 466-8550, Japan.

Objective: The aim of this study was to evaluate routine second curettage for hydatidiform mole (HM) by comparing the characteristics and outcomes of developing gestational trophoblastic neoplasia (GTN).

Study Design: This was a cohort study including 173 patients diagnosed with HM between January 2002 and August 2019 who were followed up at Nagoya University Hospital, Japan. After an evacuation, 105 and 68 patients were managed with the routine method (routine group) and elective method (elective group) for a second curettage, respectively. Read More

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http://dx.doi.org/10.1007/s10147-020-01640-xDOI Listing

Single or two drug combination therapy as initial treatment for low risk, gestational trophoblastic neoplasia. A Canadian analysis.

Gynecol Oncol 2020 May 4;157(2):367-371. Epub 2020 Mar 4.

Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, Ontario M4N3M5, Canada.

Introduction: Low risk gestational trophoblastic neoplasia, WHO prognostic score of 0 to 6, is highly curable. There is no consensus on the optimal chemotherapy. Common regimens are q2wk actinomycin-D (ACT-D), weekly intramuscular methotrexate (MTX) or multi-day MTX. Read More

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http://dx.doi.org/10.1016/j.ygyno.2020.02.005DOI Listing

Risk factors for second-line dactinomycin failure after methotrexate treatment for low-risk gestational trophoblastic neoplasia: a retrospective study.

BJOG 2020 Mar 6. Epub 2020 Mar 6.

Department of Medical Oncology, Radboud University Medical Centre, Nijmegen, The Netherlands.

Objective: To find risk factors for second-line dactinomycin failure in patients with low-risk gestational trophoblastic neoplasia (GTN).

Design: Retrospective multicentre study.

Setting: Tertiary reference centre. Read More

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http://dx.doi.org/10.1111/1471-0528.16198DOI Listing

Stage IV choriocarcinoma in a 47-year-old-woman 12 years after her last known pregnancy: A case report.

Case Rep Womens Health 2020 Apr 30;26:e00180. Epub 2020 Jan 30.

Department of Obstetrics and Gynaecology, Gosford Hospital, Australia.

Introduction: Choriocarcinoma is a rare, invasive, gestational trophoblastic disease that secretes high levels of beta human chorionic gonadotropin (BhCG) and is thought to affect 1 in 40,000 pregnancies. We present a rare case of metastatic choriocarcinoma.

Case Presentation: A 47-year-old woman presented with shortness of breath, anemia and an elevated serum BhCG level. Read More

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http://dx.doi.org/10.1016/j.crwh.2020.e00180DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7033518PMC

Complete Molar Pregnancy in Posmenopausal Woman-a Case Report.

Med Arch 2019 Dec;73(6):436-437

University Department of Gynecology and Obstetrics, University Clinical Center, Tuzla, Bosnia and Herzegovina.

Introduction: Gestational trophoblastic desease (GTD) is disease typical for reproductive period of women and is extremly rare in postmenopausal period of woman's life.

Aim: To present a rare case of mollar pregnancy in 57 years of age postmenopausal woman.

Case Report: A multiparous woman aged 57 years, and two yars after last menstrual bleeding, was admitted at Clinic, due to hyperplastic endometrium findings and moderate prolonged postmenopausal uterine bleeding. Read More

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http://dx.doi.org/10.5455/medarh.2019.73.436-437DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7007621PMC
December 2019

Conservative management of uterine rupture in gestational trophoblastic neoplasia.

Gynecol Oncol Rep 2020 May 30;32:100539. Epub 2020 Jan 30.

Department of Gynecologic Oncology, Icahn School of Medicine at Mount Sinai, United States.

•Uterine artery embolization as management of uterine rupture due to invasive GTN.•Fertility preservation for select cases of uterine rupture due to invasive GTN.•Conservative surgery and chemotherapy for invasive GTN with uterine rupture. Read More

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http://dx.doi.org/10.1016/j.gore.2020.100539DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7011027PMC

Pre-operative classification of molar pregnancy: How good is ultrasound?

Aust N Z J Obstet Gynaecol 2020 Feb 17. Epub 2020 Feb 17.

Acute Gynaecology, Early Pregnancy and Advanced Endosurgery Unit, Nepean Clinical School- University of Sydney, Sydney, New South Wales, Australia.

Background: Histopathology is the reference standard for diagnosing hydatidiform molar pregnancy (HMP).

Aim: To assess the performance of pre-operative transvaginal ultrasound (TVS) to predict HMP.

Materials And Methods: A retrospective diagnostic accuracy study was performed on women who had both TVS and histopathological examination of uterine curettings between January 2011-February 2017. Read More

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http://dx.doi.org/10.1111/ajo.13130DOI Listing
February 2020

Insights into the hyperglycosylation of human chorionic gonadotropin revealed by glycomics analysis.

PLoS One 2020 11;15(2):e0228507. Epub 2020 Feb 11.

Department of Life Sciences, Imperial College London, London, United Kingdom.

Human chorionic gonadotropin (hCG) is a glycoprotein hormone that is essential for the maintenance of pregnancy. Glycosylation of hCG is known to be essential for its biological activity. "Hyperglycosylated" variants secreted during early pregnancy have been proposed to be involved in initial implantation of the embryo and as a potential diagnostic marker for gestational diseases. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0228507PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7012436PMC

Effectiveness and toxicity of second-line actinomycin D in patients with methotrexate-resistant postmolar low-risk gestational trophoblastic neoplasia.

Gynecol Oncol 2020 May 7;157(2):372-378. Epub 2020 Feb 7.

New England Trophoblastic Disease Center, Division of Gynecologic Oncology, Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women's Hospital, MA, USA; Harvard Medical School, Boston, MA, USA.

Objectives: The purpose of this study was to evaluate both the outcomes and toxicity of second-line actinomycin D (ActD) chemotherapy in methotrexate (MTX) - resistant low-risk postmolar gestational trophoblastic neoplasia (GTN) with 5-day ActD versus pulsed ActD.

Methods: This retrospective cohort study included patients with MTX-resistant low-risk postmolar GTN from 1974 to 2016. Second-line chemotherapy consisted of 5-day ActD (10-12 μg/kg per day for 5 days every 14 days) or biweekly ActD (1. Read More

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http://dx.doi.org/10.1016/j.ygyno.2020.02.001DOI Listing

The 16-year experience in treating low-risk gestational trophoblastic neoplasia patients with failed primary methotrexate chemotherapy.

J Gynecol Oncol 2020 Jan 7. Epub 2020 Jan 7.

Department of Gynecologic Oncology, Women's Hospital, School of Medicine Zhejiang University, Hangzhou, China.

Objective: To assess the outcomes and toxic effects of 5-day actinomycin D (Act-D) salvage therapy and to explore the predictors of Act-D resistance in patients with low-risk gestational trophoblastic neoplasia (GTN)who failed 5-day methotrexate (MTX) chemotherapy.

Methods: This retrospective study analyzed patients with low-risk GTN administered Act-D salvage therapy after failing MTX chemotherapy at Women's Hospital, Zhejiang University School of Medicine between January 2000 and December 2015. The clinical parameters of these patients were collected and analyzed. Read More

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http://dx.doi.org/10.3802/jgo.2020.31.e36DOI Listing
January 2020

Management and risk factors of recurrent gestational trophoblastic neoplasia: An update from 2004 to 2017.

Cancer Med 2020 Apr 5;9(7):2590-2599. Epub 2020 Feb 5.

Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Objective: We investigated the clinical characteristics, treatments, and survival of patients with gestational trophoblastic neoplasia (GTN) who experienced recurrence. Factors predictive of recurrence were also investigated.

Methods: Patients with GTN who recurred after completing chemotherapy at Peking Union Medical College Hospital Trophoblastic Disease Center were identified between January 2004 and December 2017. Read More

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http://dx.doi.org/10.1002/cam4.2901DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7131839PMC

Next-Generation Sequencing Panel Analysis of Clinically Relevant Mutations in Circulating Cell-Free DNA from Patients with Gestational Trophoblastic Neoplasia: A Pilot Study.

Biomed Res Int 2020 8;2020:1314967. Epub 2020 Jan 8.

Obstetrics and Gynecology Hospital of Fudan University, Shanghai 200011, China.

Gestational trophoblastic neoplasia (GTN) originates from placental tissue and exhibits the potential for invasion and metastasis. Gene alterations in GTN have not been extensively studied because of a lack of qualified tumor specimens after chemotherapy. GTN has a rapid growth rate and is highly metastatic, which makes circulating tumor DNA (ctDNA) sequencing a promising modality for gene profiling. Read More

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http://dx.doi.org/10.1155/2020/1314967DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6970497PMC
January 2020

Metastatic Brain Choriocarcinoma in a Postmenopausal Woman: A Case Report.

Am J Case Rep 2020 Jan 27;21:e917656. Epub 2020 Jan 27.

Department of Women's Health, Arrowhead Regional Medical Center, Colton, CA, USA.

BACKGROUND Choriocarcinoma is the most aggressive form of gestational trophoblastic disease and usually occurs in women of childbearing age, most commonly within 1 year after an abnormal pregnancy. Postmenopausal choriocarcinoma is exceptionally rare and few cases have been described in the literature. CASE REPORT We present the case of a 66-year-old woman who presented to the Emergency Department with sudden onset of left upper- and lower-extremity weakness. Read More

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http://dx.doi.org/10.12659/AJCR.917656DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6998797PMC
January 2020

The impact of previous cesarean section (C/S) on the risk for post-molar gestational trophoblastic neoplasia (GTN).

Gynecol Oncol 2020 Mar 15;156(3):606-610. Epub 2020 Jan 15.

Department of Obstetrics and Gynecology, Korea University Guro Hospital, College of Medicine, Korea University, Seoul, Republic of Korea. Electronic address:

Objective: To investigate the relationship between previous cesarean section (C/S) and risk for post-molar gestational trophoblastic neoplasia (GTN).

Methods: Data from patients who were treated for hydatidiform moles between 1995 and 2016 were retrospectively reviewed. Patient age, gravidity, parity, abortion history, gestational age, pretreatment beta-human chorionic gonadotropin (HCG), previous molar pregnancy, clinical symptoms, enlarged uterus, theca lutein cyst, type of GTN, World Health Organization risk score, chemotherapy, and mode of delivery were recorded. Read More

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http://dx.doi.org/10.1016/j.ygyno.2019.11.032DOI Listing

Delivery of Euthyroid Baby following Hyperthyroidism in Twin Gestation with Coexisting Complete Hydatidiform Mole.

Case Rep Endocrinol 2019 26;2019:2941501. Epub 2019 Dec 26.

Department of Endocrinology, Diabetes and Metabolism, University of Kentucky, Lexington, KY, USA.

Context: Gestational trophoblastic disease (GTD) is a rare complication of pregnancy, ranging from molar pregnancy to choriocarcinoma. Twin pregnancies with GTD and coexisting normal fetus are extremely rare with an estimated incidence of 1 case per 22,000-100,000 pregnancies. Molecular mimicry between human chorionic gonadotrophin (hCG) and thyroid-stimulating hormone (TSH) leads to gestational trophoblastic hyperthyroidism (GTH) which is further associated with increased maternal and fetal complications. Read More

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http://dx.doi.org/10.1155/2019/2941501DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6944968PMC
December 2019