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Br J Cancer 2019 Feb 22. Epub 2019 Feb 22.

Department of Medical Oncology, Charing Cross Gestational Trophoblastic Disease Centre, Imperial College NHS Healthcare Trust and Imperial College London, London, UK.

Background: Placental-site trophoblastic (PSTT) and epithelioid trophoblastic tumours (ETT) are the rarest malignant forms of gestational trophoblastic disease (GTD). Our prior work demonstrated that an interval of ≥48 months from the antecedent pregnancy was associated with 100% death rate, independent of the stage. Here, we assess whether modified treatments for these patients have increased survival and identify new prognostic factors. Read More

Int J Hematol Oncol Stem Cell Res 2018 Oct;12(4):291-297

Department of Obstetrics and Gynecology, Imam Reza Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran.

The present study was conducted to determine the response to treatment in patients with GTN, the survival rate and to investigate the outcomes of first pregnancy after chemotherapy. The treatment protocol was based on the FIGO Staging of GTN and the Modified WHO Prognostic Scoring. Complete remission was achieved with MTX in 100% of the low-risk patients and with combination therapy in 91% of the high-risk cases. Read More

Placenta 2019 Feb 12. Epub 2019 Feb 12.

Mother Infant Research Institute, Tufts Medical Center, Boston, MA, USA. Electronic address:

Workshops are an important part of the IFPA annual meeting as they allow for discussion of specialized topics. At IFPA meeting 2018 there were nine themed workshops, five of which are summarised in this report. These workshops discussed new perspectives and knowledge in the following areas of research: 1) preeclampsia; 2) abnormally invasive placenta; 3) placental infection; 4) gestational trophoblastic disease; 4) drug delivery to treat placental dysfunction. Read More

Metabolites 2019 Feb 9;9(2). Epub 2019 Feb 9.

Gynecologic Oncology Department, Poznan University of Medical Sciences, Polna 33, 60-535 Poznan, Poland.

Gestational trophoblastic disease (GTD) is a group of highly aggressive, rare tumors. Human chorionic gonadotropin is a common biomarker used in the diagnosis and monitoring of GTD. To improve our knowledge of the pathology of GTD, we performed protein-peptide profiling on the urine of patients affected with gestational trophoblastic neoplasm (GTN). Read More

J Gynecol Oncol 2018 Nov 23. Epub 2018 Nov 23.

Women's Reproductive Health Laboratory of Zhejiang Province, Women's Hospital, Zhejiang University School of Medicine, Hangzhou, China.

Objective: To investigate the significance of lung nodule in hydatidiform mole, we retrospectively compared the clinical outcomes of those patients treated with different strategies.

Methods: The patients were divided into three groups: chemotherapy immediately once lung nodule was detected (group 1, n=17), delayed chemotherapy until human chorionic gonadotrophin (hCG) level met the diagnostic criteria for gestational trophoblastic neoplasia (GTN) (group 2, n=18), and hCG surveillance alone until hCG level was normalized spontaneously (group 3, n=18). The clinical parameters of these patients were collected and analyzed. Read More

Eur J Cancer 2019 Feb 4;109:162-171. Epub 2019 Feb 4.

Department of Medical Oncology, Charing Cross Hospital Campus of Imperial College, London, UK. Electronic address:

Objective: The objective of the study was to evaluate the effect of high-dose chemotherapy (HDC) with peripheral blood stem cell support (PBSCS) on survival of patients with gestational trophoblastic neoplasia (GTN) with either refractory choriocarcinomas or a poor-prognosis placental site/epithelioid trophoblastic tumours (PSTT/ETTs).

Methods: Databases of two referral centres for gestational trophoblastic disease were searched, and 32 patients treated with HDC between 1994 and 2015 were identified. Tissue samples were retrieved for genetic evaluation. Read More

Eur Respir Rev 2019 Mar 6;28(151). Epub 2019 Feb 6.

National Pulmonary Hypertension Service, Royal Brompton Hospital, Imperial College London, London, UK.

Tumoral pulmonary hypertension (PH) comprises a variety of subtypes in patients with a current or previous malignancy. Tumoral PH principally includes the tumour-related pulmonary microvascular conditions pulmonary tumour microembolism and pulmonary tumour thrombotic microangiopathy. These inter-related conditions are frequently found in specimens but are notoriously difficult to diagnose The outlook for patients remains extremely poor although there is some emerging evidence that pulmonary vasodilators and anti-inflammatory approaches may improve survival. Read More

Indian J Pathol Microbiol 2019 Jan-Mar;62(1):142-145

Department of Pathology and Laboratory Medicine, King Saud University and King Khalid University Hospital, Riyadh, Saudi Arabia.

One of the very rare forms of gestational neoplastic diseases is the malignant placental site trophoblastic tumor. Due to its rarity, the data regarding its diagnosis and management are limited. The prognosis of this tumor is unpredictable with potential malignant behavior and metastasis. Read More

Indian J Pathol Microbiol 2019 Jan-Mar;62(1):54-60

Department of Pathology, S.C.B. Medical Colllege, Cuttack, Odisha, India.

Background: Gestational trophoblastic disease (GTD) constitutes a spectrum of tumors and tumor-like conditions, characterized by proliferation of pregnancy-associated trophoblastic tissue of progressive malignant potential. It is very difficult to differentiate these complex groups of lesions basing on histomorphology alone. Immunohistochemistry (IHC) with cyclin E, P63, and Ki-67 has a definite role in the identification of different trophoblasts and entities of GTD and also in the determination of biological behavior. Read More

Int J Gynecol Cancer 2019 Jan 29. Epub 2019 Jan 29.

Department of Gynaecologic Oncology, Kidwai Memorial Institute of Oncology, Bengaluru, Karnataka, India.

Objectives: To assess the importance of salvage therapy in the management of high-risk gestational trophoblastic neoplasia (HR GTN) after failure of first line multiagent chemotherapy.

Methods: This retrospective study involving women with HR GTN treated at Kidwai cancer institute from 2000 to 2015. Initial chemotherapy consisted of etoposide, methotrexate with folinic acid, actinomycin D, cyclophosphamide and vincristine (EMA-CO). Read More

Eur J Obstet Gynecol Reprod Biol 2019 Mar 6;234:117-119. Epub 2019 Jan 6.

Trophoblastic Disease Centre, Charing Cross Hospital, London, UK.

Objective: To determine whether post-pregnancy human chorionic gonadotrophin screening after previous hydatidiform mole identifies patients with recurrent gestational trophoblastic disease.

Study Design: A retrospective evaluation of 9315 patients who underwent post-pregnancy screening from 2000 to 2009, as part of the National Gestational Trophoblastic Disease Service in the UK.

Results: Patients with previous hydatidiform mole, who had human chorionic gonadotrophin screening after one or more subsequent pregnancies, were identified (n = 9315). Read More

J Cancer 2019 1;10(1):11-19. Epub 2019 Jan 1.

Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730, PR China.

Epithelioid trophoblastic tumors (ETTs) are the rarest type of gestational trophoblastic neoplasias. We investigated the clinical features, treatments, outcomes, and prognostic factors in patients with ETT, and explored potential therapeutic targets. We retrospectively analyzed the clinical features, treatments, survival, and prognostic factors of 21 ETT patients treated at our institution between January 2002 and December 2017. Read More

Hum Reprod Update 2019 Jan 11. Epub 2019 Jan 11.

Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology and Key Laboratory of Assisted Reproduction, Department of Obstetrics and Gynecology, Ministry of Education, Center for Reproductive Medicine, Peking University Third Hospital, Beijing, China.

Background: Initially identified as suppressors of metastasis in various types of cancer, kisspeptins are a family of neuropeptides that are key regulators of the mammalian reproductive axis. Accumulating evidence has shown that kisspeptin is able to control both the pulsatile and surge GnRH release, playing fundamental roles in female reproduction, which include the secretion of gonadotropins, puberty onset, brain sex differentiation, ovulation and the metabolic regulation of fertility. Furthermore, recent studies have demonstrated the involvement of the kisspeptin system in the processes of implantation and placentation. Read More

Int J Gynecol Cancer 2019 Jan;29(1):108-112

Department of Obstetrics and Gynaecology, Radboud University Medical Centre, Nijmegen, The Netherlands.

Objectives: Because gestational trophoblastic disease is rare, little evidence is available from randomized controlled trials on optimal treatment and follow-up. Treatment protocols vary within Europe, and even between different centers within countries. One of the goals of the European Organization for Treatment of Trophoblastic Diseases (EOTTD) is to harmonize treatment in Europe. Read More

Expert Rev Mol Diagn 2019 Feb 29;19(2):175-188. Epub 2019 Jan 29.

a Department of Pathology , Yale University School of Medicine , New Haven , CT , USA.

Introduction: Among various human tissue identity testing platforms, short tandem repeat (STR) genotyping has emerged as the most powerful and cost-effective method. Beyond forensic applications, tissue identity testing has become increasingly important in modern medical practice, in areas such as diagnostic pathology. Areas covered: A brief overview of various molecular/genetic techniques for identity testing is provided. Read More

Ginekol Pol 2018 ;89(12):711-715

The Chair and Clinic of Obstetrics, Gynaecologic Diseases and Oncological Gynaecology of the Second Faculty of Medicine of Warsaw Medical University, Poland.

Choriocarcinoma is one of rare neoplasms of female reproductive organs. In the last decade only a few cases of this disease have been registered in Poland. The paper presents the current principles of diagnosis and treatment options for this rare disease based on the authors' clinical experience (description of the case) and literature review. Read More

BMC Cancer 2019 Jan 7;19(1):13. Epub 2019 Jan 7.

Department of Obstetrics and Gynecology, Women's Hospital, Zhejiang University School of Medicine, No.1 Xueshi Road, Hangzhou, 310006, Zhejiang Province, China.

Background: The clinical value of total hysterectomy for patients with hydatidiform mole (HM) being at least 40 years old remains highly controversial. Since the practice of hysterectomy has been applied globally for decades, there is an urgent need to perform a systematic review to assess its risks and benefits.

Methods: Six electronic databases, including four English databases and one Chinese database, were searched from the inception of each database till October 6th 2017. Read More

Wellcome Open Res 2016 6;1:32. Epub 2018 Dec 6.

Shoklo Malaria Research Unit, Mahidol-Oxford Tropical Medicine Research Unit, Mahidol University, Mae Sot, Thailand.

No universal  demarcation of gestational age  distinguishes miscarriage and stillbirth or extreme preterm birth (exPTB). This study provides a synopsis of outcome between 22 to <28 weeks gestation from a low resource setting. A retrospective record review of a population on the Thailand-Myanmar border was conducted. Read More

J Assist Reprod Genet 2019 Jan 5. Epub 2019 Jan 5.

Department of Reproductive Medicine, Saint Mary's Hospital, Manchester Academic Health Sciences Centre, Manchester University NHS Foundation Trust, Oxford Road, Manchester, M13 9WL, UK.

Introduction: The use of assisted reproduction techniques (ART) is increasing; however, reports of molar pregnancy following ART remain scarce. Currently, the Human Fertility and Embryology Authority (HFEA) collates data on the molar pregnancies that have resulted through the use of ART. Recently, they have indicated that they will no longer collect these data. Read More

Zhonghua Yi Xue Za Zhi 2018 Dec;98(47):3896-3899

Department of Obstetrics and Gynecology, Women's Hospital, School of Medicine, Zhejiang University, Hangzhou 310006, China.

This study aims to evaluate the efficacy of EMA-CO as an initial regimen for high-risk gestational trophoblastic neoplasia and to analysis the influenced factors. A total of 81 patients with high-risk gestational trophoblastic neoplasia (HRGTN) treated in Women Hospital Affiliated Zhejiang University from Jan 2007 to Jan 2017 whose primary chemotherapies were EMA-CO were enrolled.The International Federation of Gynecology and Obstetrics (FIGO) prognosis score of all the patients was ≥7. Read More

Arch Gynecol Obstet 2018 Dec 19. Epub 2018 Dec 19.

Department of Gynecology and Obstetrics, Ruhr University Bochum, Herne, Germany.

Background And Purpose: Choriocarcinoma (CCA) is a rare form of malignant trophoblastic disease. Systemic polychemotherapy with etoposide, methotrexate, actinomycin D, cyclophosphamide, and vincristine (EMA/CO) is the mainstay of treatment for metastatic disease. Due to the rarity of the condition, however, the evidence basis for this management is small and other chemotherapy regimens may also be effective. Read More

Nuklearmedizin 2018 Dec 18;57(6):N57. Epub 2018 Dec 18.

Gynecol Oncol Rep 2018 Nov 31;26:102-104. Epub 2018 Oct 31.

Division of Gynecologic Oncology, The University of Iowa Hospitals and Clinics, United States.

When elevated serum hCG is discovered during the work up of a gynecologic tumor, it is paramount to identify the source of hCG prior to initiation of treatment. Potential sources of hCG include viable intrauterine pregnancy, ectopic pregnancy, miscarriage, gestational trophoblastic disease, pituitary hCG production, phantom hCG (heterophilic antibody interference), and tumor production. Here, we present a case of elevated hCG in a young women with a large complex pelvic mass. Read More

Obstet Gynecol 2019 Jan;133(1):163-166

Departments of Obstetrics and Gynecology and Pathology, Tufts Medical Center, Boston, Massachusetts.

Background: Gestational trophoblastic neoplasia rarely occurs in term pregnancies. Stage IV choriocarcinoma treated with conventional chemotherapy can result in death as a result of hemorrhagic sequelae at tumor sites.

Case: A 30-year-old woman at 34 weeks of gestation presented with a persistent cough, worsening dyspnea, and vaginal bleeding. Read More

Medicine (Baltimore) 2018 Nov;97(48):e13439

Interdisciplinary Department of Medicine, Gynecology and Obstetrics Clinic, University of Bari.

Rationale: Placental site trophoblastic tumor (PSTT) is a very rare malignant tumor, belonging to a family of pregnancy-related illnesses, called gestational trophoblastic diseases (GTD). Less than 300 cases of PSTT have been reported in literature, with an incidence of ≈ 1/50,000-100,000 pregnancies representing only 0.23% to 3. Read More

Arch Pathol Lab Med 2018 Dec;142(12):1485-1502

From the Department of Pathology, The Johns Hopkins Hospital, Baltimore, Maryland.

Context.—: Distinction of hydatidiform moles from nonmolar specimens and subclassification of hydatidiform moles as complete hydatidiform mole versus partial hydatidiform mole are important for clinical practice and investigational studies. Risk of persistent gestational trophoblastic disease and clinical management differ for these entities. Read More

Gynecol Oncol 2019 02 22;152(2):361-367. Epub 2018 Nov 22.

Department of Medical Oncology, Charing Cross Hospital, London, United Kingdom.

Objective: Epithelioid Trophoblastic Tumor (ETT) is an extremely rare form of Gestational Trophoblastic Neoplasia (GTN). Knowledge on prognostic factors and optimal management is limited. We identified prognostic factors, optimal treatment, and outcome from the world's largest case series of patients with ETT. Read More

J Int Med Res 2019 Feb 9;47(2):673-681. Epub 2018 Nov 9.

1 Department of Gynecology, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China.

Objective: This study aimed to determine the diagnostic value of magnetic resonance imaging (MRI), hysteroscopy, and laparoscopy to avoid unnecessary treatment when patients present with clinical manifestations that are close to those of gestational trophoblastic neoplasia (GTN).

Methods: Three patients who were falsely diagnosed with presumed GTN and received needless chemotherapy in our hospital from July 2011 to March 2012 were studied. We also reviewed data of patients with similar clinical features who were diagnosed as having residual pregnancy in recent years. Read More

Arch Pathol Lab Med 2019 Jan 8;143(1):65-74. Epub 2018 Nov 8.

From the Department of Pathology, Yale University School of Medicine, New Haven, Connecticut.

Context.—: Gestational trophoblastic tumors include 3 distinct entities: gestational choriocarcinoma, placental site trophoblastic tumor, and epithelioid trophoblastic tumor. Accurate diagnosis is important for clinical management of the patient. Read More

Oncol Lett 2018 Nov 20;16(5):6458-6464. Epub 2018 Sep 20.

Jiangxi Provincial Key Laboratory of Reproductive Physiology and Pathology, Department of Physiology, School of Medicine, Nanchang University, Nanchang, Jiangxi 330006, P.R. China.

Uterine natural killer (uNK) cells have been hypothesized to serve a role in controlling trophoblast invasion and proliferation. The aim of the present study was to identify the distribution and number of uNK cells in normal pregnancy (NP), partial mole (PM), complete mole (CM) and invasive mole (IM). uNK cells were detected using dolichos biflorus agglutinin lectin immunohistochemistry in decidual and villous tissues from early NP (n=15), late NP (n=15), PM (n=22), CM (n=20) and IM (n=10). Read More

Cell Physiol Biochem 2018 5;50(5):1815-1831. Epub 2018 Nov 5.

Department of Obstetrics and Gynecology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an,

Background/aims: Choriocarcinoma (CC) is a highly aggressive gestational trophoblastic neoplasia; however, the underlying molecular mechanisms of its invasiveness and metastasis remain poorly understood. Human secreted frizzled-related protein 2 (SFRP2) could function as a tumor promoter or suppressor in different tumors, yet the role it plays in CC's invasion and metastasis is thoroughly unclear. The current study was aimed to explore the function and underlying mechanism of SFRP2 in CC. Read More

Int J Gynecol Cancer 2018 Nov;28(9):1766-1771

Pôle Information Médicale Evaluation Recherche, Equipe d'Accueil 4129, Hospices Civils de Lyon, Lyon.

Objective: This study aimed to assess the outcome of first-line hysterectomy in patients diagnosed as having gestational trophoblastic neoplasia (GTN) whose postoperative imaging showed lung images considered as metastases.

Methods: From 1999 to 2016, patients no longer wishing to conceive, treated by their initial physician by hysterectomy, and whose postoperative imaging workup showed lung images considered as metastasis were identified in the French Trophoblastic Disease Reference Center database. We sought to identify significant predictive factors of requiring salvage chemotherapy. Read More

Int J Gynecol Cancer 2018 Nov;28(9):1772-1780

Department of Reproductive Medicine, Graduate School of Medicine, Chiba University, Chiba, Japan.

Objective: The aim of this study was to evaluate the incidence and risk factors of gestational trophoblastic neoplasia (GTN) from hydatidiform moles (HMs) cytogenetically diagnosed in a prospective cohort setting.

Methods: The prospective observational cohort study included cases of cytogenetically defined molar pregnancies, which were diagnosed by a multiplex short tandem repeat polymorphism analysis. Cases were classified as androgenetic complete HMs (CHMs), diandric monogynic triploid partial HMs (PHMs), or biparental abortion. Read More

Cureus 2018 Aug 21;10(8):e3175. Epub 2018 Aug 21.

Internal Medicine, Dow Medical College, Karachi, PAK.

We report a case of partial mole and co-existing live fetus. This condition, uncommonly termed "sad fetus syndrome," is a rare subclass of gestational trophoblastic disease. Our case involves a 25-year-old primigravid woman who presented to the outpatient department at 18 weeks of gestation with lower abdominal pain, vaginal spotting, and severe nausea. Read More

Med J Malaysia 2018 Oct;73(5):332-333

Sarawak General Hospital, Radiotherapy and Oncology Department, Kuching, Sarawak, Malaysia.

No abstract provided. Read More

Int J Gynaecol Obstet 2018 Oct;143 Suppl 2:79-85

Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Radboud University Medical Centre Nijmegen, Nijmegen, Netherlands.

Gestational trophoblastic disease (GTD) arises from abnormal placenta and is composed of a spectrum of premalignant to malignant disorders. Changes in epidemiology of GTD have been noted in various countries. In addition to histology, molecular genetic studies can help in the diagnostic pathway. Read More

Kobe J Med Sci 2018 May 28;64(1):E1-E5. Epub 2018 May 28.

Department of Obstetrics and Gynecology, Kobe University Graduate School of Medicine, Kobe, Japan.

Background: Both twin pregnancies with complete hydatidiform mole and coexisting normal fetus (CHMCF) and partial hydatidiform mole can be found in association with a live fetus and a placenta displaying a molar degeneration. Two cases of CHMCF using magnetic resonance imaging (MRI) for a diagnosis are reported.

Case: In the first, CHMCF was suspected at 12 weeks of gestation. Read More

Clin Nephrol Case Stud 2018 20;6:27-30. Epub 2018 Sep 20.

Department of Hematology, Nephrology, and Rheumatology, Akita University Graduate School of Medicine, and.

A 32-year-old woman presented with amenorrhea after a normal childbirth and subsequently developed nephrotic syndrome. Renal biopsy showed a thrombotic microangiopathy (TMA)-like glomerular lesion with deposits of immunoglobulins, complements, and fibrinogen. Increased serum levels of the beta subunit of human chorionic gonadotropin, abnormal uterine findings from imaging studies, and endometrial biopsy findings suggested gestational trophoblastic disease. Read More

Eur J Obstet Gynecol Reprod Biol 2018 Nov 25;230:136-140. Epub 2018 Sep 25.

Obstetrics and Gynecology Hospital, Fudan University, Shanghai, China; Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Shanghai, China. Electronic address:

Objective: We conducted a comprehensive analysis of gestational trophoblastic neoplasia (GTN) trials posted at online registries and aimed to provide useful information for future GTN trial designs.

Study Design: We searched ClinicalTrials.gov, EU Clinical Trials Register, WHO International Clinical Trials Registry Portal (ICTRP) Search Portal, Australian New Zealand Clinical Trial Registry, ISRCTN Register, and Chinese Clinical Trial Register for all the clinical trials reporting GTN treatments. Read More

Gynecol Oncol 2018 12 26;151(3):449-452. Epub 2018 Sep 26.

Obstetrics and Gynecology Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy.

Objective: To compare clinical outcomes of patients diagnosed with low-risk gestational trophoblastic neoplasia (GTN) receiving intramuscular methotrexate 50 mg total dose/day versus 1 mg/kg/day in a 8-day methotrexate/folinic acid (MTX/FA) regimen.

Methods: This retrospective, multicenter study included 176 patients: 99 (56%) receiving methotrexate 50 mg total dose/day on days 1, 3, 5, 7 alternated with FA 7,5 mg on days 2, 4, 6, 8, every 14 days (group A); and 77 patients (44%), receiving methotrexate 1 mg/kg/day on days 1, 3, 5, 7 alternated with FA 7,5 mg on days 2, 4, 6, 8, every 14 days (group B). Patients' characteristics and outcomes were compared by univariate analysis. Read More

BMJ Case Rep 2018 Sep 27;2018. Epub 2018 Sep 27.

Department of Obstetrics and Gynaecology, Our Lady of Lourdes Hospital, Drogheda, Ireland.

The classic features of molar pregnancy are irregular vaginal bleeding, hyperemesis, enlarged uterus for gestational age and early failed pregnancy. Less common presentations include hyperthyroidism, early onset pre-eclampsia or abdominal distension due to theca lutein cysts. Here, we present a case of molar pregnancy where a woman presented to the emergency department with symptoms of acute abdomen and was treated as ruptured ectopic pregnancy. Read More

Facts Views Vis Obgyn 2017 Dec;9(4):207-216

Antwerp University Hospital UZA, Department of Obstetrics and Gynaecology, Wilrijkstraat 10, 2650 Edegem,Belgium.

Background: The goal of this review is to evaluate the value of ultrasound for detection of retained products of conception (RCOP) after delivery.

Methods: A systematic search was performed using 'postpartum', 'retained placenta', 'retained products' and 'ultrasound' resulting 82 publications, after screening titles and abstracts, 30 remained.

Results: On gray scale ultrasound, one must be focus on a thickened endometrial echo complex (EEC) with a cut off value of 10 mm and on an intracavitary mass. Read More

J Med Internet Res 2018 Sep 24;20(9):e10897. Epub 2018 Sep 24.

Division of Gynecologic Oncology, Obstetrics and Gynecology, Harvard Medical School, Boston, MA, United States.

Background: The term gestational trophoblastic disease (GTD) includes both complete and partial moles, which are uncommon nonviable pregnancies with the potential to evolve into a malignancy known as gestational trophoblastic neoplasia. While highly curable, the potential for malignancy associated with molar pregnancies worries the patients, leading them to seek information on the internet. A Facebook page headed by Brazilian specialized physicians in GTD was created in 2013 to provide online support for GTD patients. Read More

Int J Clin Oncol 2019 Feb 21;24(2):153-160. Epub 2018 Sep 21.

Department of Gynecological Surgery and Oncology, Obstetrics, University of Lyon 1, University Hospital Lyon Sud, Pierre-Bénite, France.

Objective: To evaluate the survival and functional outcome of patients with brain metastasis due to gestational trophoblastic neoplasia (GTN).

Methods: A 17-year retrospective study based on case review of women with brain metastasis from GTN identified by the electronic databases held in the French Reference Centre.

Primary Outcome Measure: 5-year overall survival calculated with the Kaplan-Meier method. Read More

Medicine (Baltimore) 2018 Sep;97(38):e12424

Department of Obstetrics and Gynecology, West China Second Hospital of Sichuan University.

Rationale: Familial hydatidiform mole is extremely rare while familial gestational trophoblastic neoplasia (GTN) has never been reported. Inspired by 2 biological sisters with postmolar GTN and liver toxicity, we reviewed susceptible maternal-effect genes and explored the role of possible drug transporter genes in the development of GTN.

Patient Concerns: We reported one Chinese family where the two sisters developed postmolar GTN while experiencing fast remission and significant hepatic toxicity from actinomycin D chemotherapy. Read More

Medicine (Baltimore) 2018 Sep;97(37):e12275

Rationale: Choriocarcinoma is the most malignant type of gestational trophoblastic neoplasia. Brain metastasis is the main cause of death and disability in choriocarc- inoma patients. Brain metastasis of choriocarcinoma easily invades the vessel wall to form microaneurysms, so we have reason to believe that multiple intracerebral hemorrhage is related to neoplastic intracranial microaneurysms. Read More

J Zoo Wildl Med 2018 Sep;49(3):828-832

A 47-yr-old multiparous female bonobo ( Pan paniscus) tested positive for pregnancy on a routine urine test. Because this geriatric animal was considered postreproductive, oral contraception had been discontinued. Sequential transabdominal ultrasound evaluations were performed under voluntary behavior and revealed that the uterus contained a mass of heterogenous tissue which was rapidly increasing in size. Read More

J Gynecol Oncol 2018 Nov;29(6):e89

Department of Reproductive Medicine, Chiba University Graduate School of Medicine, Chiba, Japan.

Objective: Highly effective chemotherapy for patients with low-risk gestational trophoblastic neoplasia (GTN) is associated with almost a 100% cure rate. However, 20%-30% of patients treated with chemotherapy need to change their regimens due to severe adverse events (SAEs) or drug resistance. We examined the treatment outcomes of second-line chemotherapy for patients with low-risk GTN. Read More

Life Sci 2018 Oct 6;211:25-30. Epub 2018 Sep 6.

Gynecologic Oncology Department, Poznan University of Medical Sciences, Polna 33, 60-535 Poznan, Poland.

Aims: Gestational trophoblastic neoplasms (GTN) exemplify a rare, mostly curable but highly aggressive disease. It is often associated with a rapid formation of distant metastases and most likely with an intense neoangiogenesis processes. The aim of the study was to analyze markers in serum of patients with GTN before chemotherapy compared to healthy pregnant women. Read More