152,764 results match your criteria Gestational Trophoblastic Neoplasia


Metabolic Syndrome in Very Low Birth Weight Young Adults and Controls: The New Zealand 1986 VLBW Study.

J Pediatr 2018 Dec 10. Epub 2018 Dec 10.

Christchurch Health and Development Study, University of Otago, Christchurch, New Zealand.

Objective: To assess the physical well-being and components of the metabolic syndrome in a national cohort of very low birth weight (VLBW) young adults and same age controls.

Study Design: The New Zealand VLBW Study cohort prospectively included all infants with birth weight <1500 g born in 1986, with 338 (82%) surviving to discharge home. Height and weight were measured at age 7-8 years. Read More

View Article
December 2018

Magnitude of fetal macrosomia and its associated factors at public health institutions of Hawassa city, southern Ethiopia.

BMC Res Notes 2018 Dec 13;11(1):888. Epub 2018 Dec 13.

School of Public Health, College of Medicine and Health Sciences, Hawassa University, Hawassa, Ethiopia.

Objectives: This study aimed to determine the magnitude of fetal macrosomia and associated factors at public health institutions of Hawassa city, southern Ethiopia.

Results: In this study, the magnitude of fetal macrosomia found to be 11.86%. Read More

View Article
December 2018

The association between active tobacco use during pregnancy and growth outcomes of children under five years of age: a systematic review and meta-analysis.

BMC Public Health 2018 Dec 13;18(1):1372. Epub 2018 Dec 13.

Nutrition Innovation, PATH, 2201 Westlake Avenue, Suite 200, Seattle, WA, 98121, USA.

Background: Despite considerable global efforts to reduce growth faltering in early childhood, rates of stunting remain high in many regions of the world. Current interventions primarily target nutrition-specific risk factors, but these have proven insufficient. The objective of this study was to synthesize the evidence on the relationship between active tobacco use during pregnancy and growth outcomes in children under five years of age. Read More

View Article
December 2018

Compressive radial neuropathy by a synovial cyst during pregnancy: A clinical case report.

Medicine (Baltimore) 2018 Dec;97(49):e13455

Department of Physical Medicine and Rehabilitation, Tung's Taichung Metroharbor Hospital, Taichung, Taiwan.

Rationale: Compressive radial neuropathy by a synovial cyst in the radial tunnel during pregnancy is a rare occurrence. The management of radial nerve compression caused by a synovial cyst in a pregnant patient is a surgical dilemma owing to the fetal and maternal risks of treatment.

Patient Concerns And Diagnosis: A 37-year-old pregnant woman presented with progressive forearm pain at the gestational age of 12 weeks. Read More

View Article
December 2018

Safety of atovaquone-proguanil during pregnancy.

J Travel Med 2018 Dec 13. Epub 2018 Dec 13.

Malaria Branch, Center for Global Health, Centers for Disease Control and Prevention, Atlanta, GA USA.

Background: Malaria during pregnancy increases the risk of maternal and fetal complications. There are very limited options available for prophylaxis in pregnant travelers. Atovaquone-Proguanil (AP or Malarone®) is an effective and well-tolerated antimalarial medication, but is not recommended for use in pregnancy due to limited data on safety. Read More

View Article
December 2018

Mean and variance of greenness and pregnancy outcomes in Tel Aviv during 2000-14: longitudinal and cross-sectional approaches.

Int J Epidemiol 2018 Dec 13. Epub 2018 Dec 13.

Ministry of Health, Jerusalem, Israel.

Background: Natural environments may have beneficial impacts on pregnancy outcomes. However, longitudinal evidence is limited and the associations with variance in surrounding greenness is unknown. Our objective was to evaluate these associations among 73 221 live births in Tel Aviv, Israel. Read More

View Article
December 2018

Indications leading to termination of pregnancy between 22 and 31 weeks of gestational age in France: A population-based cohort study.

Eur J Obstet Gynecol Reprod Biol 2018 Dec 3;233:12-18. Epub 2018 Dec 3.

Inserm UMR 1153, Obstetrical, Perinatal and Pediatric Epidemiology Research Team (Epopé), Center for Epidemiology and Statistics Sorbonne Paris Cité, DHU Risks in pregnancy, Paris Descartes University, Paris, France.

Objective: To estimate the prevalence and indications of terminations of pregnancy (TOP) between 22 and 31 weeks of gestational age in France and to examine the characteristics of women by indication of TOP.

Study Design: From the EPIPAGE 2 population-based cohort study of preterm births in France in 2011, we selected 5009 singleton live births, stillbirths and TOP that occurred between 22 and 31 weeks. We estimated the proportion of TOP by gestational age. Read More

View Article
December 2018

Field ultrasound evaluation of some gestational parameters in jennies.

Theriogenology 2018 Nov 22;126:95-105. Epub 2018 Nov 22.

Department of Veterinary Science, University of Torino, Largo Braccini 2/4, 10095, Grugliasco, TO, Italy.

The aim of this study was to collect and analyze ultrasound measurements of fetal-maternal structures during normal and pathological pregnancies in jennies, a livestock species of growing interest. For two breeding seasons, 38 jennies of different breeds and crossbreeds aged between 3 and 18 years were monitored weekly by transrectal examination using a portable Esaote ultrasound (MyLab™ 30 GOLD VET) with a 5-7.5 MHz probe. Read More

View Article
November 2018

Hepatic hexokinase domain containing 1 (HKDC1) improves whole body glucose tolerance and insulin sensitivity in pregnant mice.

Biochim Biophys Acta Mol Basis Dis 2018 Dec 10. Epub 2018 Dec 10.

Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Illinois at Chicago, IL, USA; Jesse Brown Veterans Affairs Medical Center, Chicago, IL, USA. Electronic address:

Hexokinase domain containing 1, a recently discovered putative fifth hexokinase, is hypothesized to play key roles in glucose metabolism. Specifically, during pregnancy in a recent genome wide association study (GWAS), a strong correlation between HKDC1 and 2-h plasma glucose in pregnant women from different ethnic backgrounds was shown. Our earlier work also reported diminished glucose tolerance during pregnancy in our whole body HKDC1 heterozygous mice. Read More

View Article
December 2018

Quantification of fetal steroids in nails of neonates to quantify prenatal stress and growth restriction.

Biol Psychol 2018 Dec 10. Epub 2018 Dec 10.

General Pediatrics, Neonatology and Pediatric Cardiology, Heinrich-Heine-University, Moorenstraße 5, 40225, Düsseldorf, Germany. Electronic address:

This study assesses the impact of prenatal stress and intrauterine growth restriction (IUGR) on the dehydroepiandrosterone (DHEA) and dehydroepiandrosteronesulfate (DHEAS) concentrations in nails of newborns. Nail samples were gained from 56 newborn infants. The concentration of DHEA and DHEAS was measured by liquid chromatography/tandem mass spectrometry. Read More

View Article
December 2018

Horner's Syndrome and Upper Extremity Weakness After Quadratus Lumborum Block for Postcesarean Section Analgesia: A Case Report.

A A Pract 2018 Dec 11. Epub 2018 Dec 11.

Boston University School of Medicine, Boston, Massachusetts.

A healthy, 34-year-old primigravida at 41 weeks gestational age presented for cesarean delivery due to a category 2 fetal heart tracing remote from delivery. After completion of the surgery under epidural anesthesia, bilateral quadratus lumborum blocks were performed for postoperative pain. Approximately 4 hours later, the patient developed left-sided arm weakness, left miosis, and ptosis. Read More

View Article
December 2018

Is there a relationship between restless legs syndrome and medical problems in pregnant women? A cross-sectional study in Iran.

Acta Neurol Belg 2018 Dec 12. Epub 2018 Dec 12.

Midwifery Department, Menopause Andropause Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

This study aimed to assess the relationship between RLS and medical problems among pregnant women. In this study, 700 pregnant women were recruited. A socio-demographic questionnaire and the International Restless Legs Questionnaire were used to gather information. Read More

View Article
December 2018

Arterial ischemic stroke (AIS) in childhood: clinical report from a single control center.

Childs Nerv Syst 2018 Dec 12. Epub 2018 Dec 12.

Department of Pediatrics, AOU Policlinico-Vittorio Emanuele, University of Catania, via S. Sofia 78, 95123, Catania, Italy.

Introduction: Stroke is the clinical designation for a rapidly developing loss of brain function due to an interruption in the blood supply to all or part of the brain. It is the third cause of death in adults and one of the top 10 causes in pediatric age. The perinatal period of onset is the second only to adult age group in the incidence of stroke. Read More

View Article
December 2018

Intrauterine fetal MR versus postmortem MR imaging after therapeutic termination of pregnancy: evaluation of the concordance in the detection of brain abnormalities at early gestational stage.

Eur Radiol 2018 Dec 12. Epub 2018 Dec 12.

Pediatric Radiology and Neuroradiology Department, Children's Hospital V. Buzzi - ASST Fatebenefratelli-Sacco, Via Castelvetro 32, 20154, Milan, Italy.

Background And Purpose: Fetal postmortem MR Imaging (pmMRI) has been recently used as an adjuvant tool to conventional brain autopsy after termination of pregnancy (TOP). Our purpose was to compare the diagnostic performance of intrauterine MRI (iuMRI) and pmMRI in the detection of brain anomalies in fetuses at early gestational age (GA).

Material And Methods: We retrospectively collected 53 fetuses who had undergone iuMRI and pmMRI for suspected brain anomalies. Read More

View Article
December 2018

Early life adiposity and telomere length across the life course: a systematic review and meta-analysis.

Wellcome Open Res 2017 18;2:118. Epub 2017 Dec 18.

MRC Integrative Epidemiology Unit, Population Health Sciences, University of Bristol, Bristol, UK.

: The relationship between adiposity at birth and in childhood, and telomere length is yet to be determined. We aimed to systematically review and meta-analyse the results of studies assessing associations between neonatal and childhood adiposity, and telomere length. : We searched Medline, EMBASE and PubMed for studies reporting associations between adiposity measured in the neonatal period or childhood, and leucocyte telomere length, measured at any age via quantitative polymerase chain reaction, or terminal restriction fragment analysis, either cross-sectionally, or longitudinally. Read More

View Article
December 2017

Early Inflammatory Markers for the Diagnosis of Late-Onset Sepsis in Neonates: The Nosodiag Study.

Front Pediatr 2018 13;6:346. Epub 2018 Nov 13.

Service de Pédiatrie II, Hôpital de Hautepierre, Strasbourg, France.

Early diagnosis is essential to improve the treatment and prognosis of newborn infants with nosocomial bacterial infections. Although cytokines and procalcitonin (PCT) have been evaluated as early inflammatory markers, their diagnostic properties have rarely been compared. This study evaluated and compared the ability of individual inflammatory markers available for clinician (PCT, semi-quantitative determination of IL-8) and of combinations of markers (CRP plus IL-6 or quantitative or semi-quantitative determination of IL-8) to diagnose bacterial nosocomial infections in neonates. Read More

View Article
November 2018

An embryo-fetal development toxicity study with dimethylaminoethyl ginkgolide B in rats and rabbits.

Toxicol Res (Camb) 2018 Nov 28;7(6):1225-1235. Epub 2018 Aug 28.

School of Pharmaceutical Sciences , Nanjing Tech University , Nanjing , 211816 , China . Email: ; Email:

(a herbal product) has long been used in traditional Chinese medicine to treat cerebrovascular and cardiovascular diseases. Ginkgolide B is one of the important pharmacologically active components of . Dimethylaminoethyl ginkgolide B (a novel ginkgolide B derivative) has been developed to overcome the poor water-solubility of natural drugs and to achieve higher bioavailability. Read More

View Article
November 2018

[Efficacy and safety of selective brain hypothermia therapy on neonatal hypoxic-ischemic encephalopathy].

Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 2018 Nov;30(11):1046-1050

Department of Pediatrics, the First Affiliated Hospital of Bengbu Medical College, Bengbu 233004, Anhui, China (Chen X, Peng WS, Zhang Z, Zhao Q, Zhou Y, Chen L); Department of Pediatric, Anhui Provincial Hospital, the First Affiliated Hospital of University of Science and Technology of China, Hefei 230001, Anhui, China (Pan JH). Corresponding author: Pan Jiahua, Email:

Objective: To evaluate the efficacy and safety of selective brain hypothermia (SBH) in the treatment of neonates with moderate or severe neonatal hypoxic-ischemic encephalopathy (HIE), and the effect of SBH treatment on serum levels of neuron-specific enolase (NSE) and central nervous specific protein S100.

Methods: A prospective randomized controlled trial was conducted. From January 2015 to June 2017, 42 children with moderate to severe HIE in the neonatal intensive care unit (NICU) of the First Affiliated Hospital of Bengbu Medical College were enrolled, and they were randomly divided into SBH treatment group and routine treatment group after obtaining the consent of the guardian of the children. Read More

View Article
November 2018

Baby Steps - a structured group education programme with accompanying mobile web application designed to promote physical activity in women with a history of gestational diabetes: study protocol for a randomised controlled trial.

Trials 2018 Dec 12;19(1):682. Epub 2018 Dec 12.

Diabetes Research Centre, College of Medicine, Biological Sciences and Psychology, University of Leicester, Leicester, LE5 4PW, UK.

Background: A diagnosis of gestational diabetes (GDM) is associated with an over sevenfold increase in the risk of developing type 2 diabetes (T2D), while among parous women with T2D, up to 30% have a history of GDM. Lifestyle interventions have been shown to reduce the risk of incident T2D in adults with impaired glucose tolerance, including in women with a history of GDM. The aim of this study is to establish whether a group self-management education programme, supported by a mobile web application, can improve levels of physical activity at 12 months in women who have had GDM. Read More

View Article
December 2018

Association between cesarean section and constipation in infants: the Japan Environment and Children's Study (JECS).

BMC Res Notes 2018 Dec 12;11(1):882. Epub 2018 Dec 12.

Toyama Regional Center for JECS, University of Toyama, Toyama, Japan.

Objective: There have been increasing reports on the association between cesarean section (C-section) and the subsequent development of diseases in infants. C-section affects the diversity of microbiota in the infant's gut. In the present study, we investigated the association between infants delivered by C-section and the development of constipation at 1 year old due to altered gut microbiota using data from the Japan Environment and Children's Study (JECS). Read More

View Article
December 2018

Re-comparing of three different epidemic seasons of bronchiolitis: different prophylaxis approaches.

Ital J Pediatr 2018 Dec 12;44(1):148. Epub 2018 Dec 12.

Neonatology-NICU Casilino General Hospital, via Casilina 1049, 00169, Rome, Italy.

During the last epidemic season of bronchiolitis (S2, years 2016-2017) we performed a single Centre analysis in inborn infant of 30-32 gestational age and age < 12 months who did not receive prophylaxis with palivizumab (PLV), in light of the current AIFA (Italian Drug Agency) guidelines restricting the time of the prophylaxis to those born < 30 weeks of gestational age. During that epidemic season, we observed a rising trend of bronchiolitis-related hospitalization and an increased rate of mechanical ventilation in preterm child compared to the previous one (S1, years 2015-2016) during which infants of this same gestational age received palivizumab (PLV) prophylaxis, according to the 2015 Italian Guidelines.In light of the revised AIFA guidelines (November 2017), allowing once again prophylaxis with PLV in infants of > 30 weeks gestational age, we decided to repeat our observation during the last epidemic season (S3, years 2017-2018), in order to compare ours infants of 30-32 gestational age with preterm of the same gestational age born in our unit in the previous seasons (S1 and S2), to evaluate the clinical impact of the different prophylaxis approaches. Read More

View Article
December 2018

Periconceptional folic acid supplementation and sex difference in prevention of neural tube defects and their subtypes in China: results from a large prospective cohort study.

Nutr J 2018 Dec 12;17(1):115. Epub 2018 Dec 12.

Institute of Reproductive and Child Health / Key Laboratory of Reproductive Health, National Health Commission of the People's Republic of China, Peking University, Beijing, 100191, People's Republic of China.

Background: Folic acid (FA) supplementation is known to prevent neural tube defects (NTDs). We examined whether this preventive effect differs by the sex of the infant.

Methods: Data were gathered from a large population-based cohort study in China that evaluated the effects of FA supplementation on NTDs. Read More

View Article
December 2018

Decision makers' experience of participatory dynamic simulation modelling: methods for public health policy.

BMC Med Inform Decis Mak 2018 Dec 12;18(1):131. Epub 2018 Dec 12.

The Australian Prevention Partnership Centre, Sax Institute, PO Box K617, Haymarket, Sydney, NSW, 1240, Australia.

Background: Systems science methods such as dynamic simulation modelling are well suited to address questions about public health policy as they consider the complexity, context and dynamic nature of system-wide behaviours. Advances in technology have led to increased accessibility and interest in systems methods to address complex health policy issues. However, the involvement of policy decision makers in health-related simulation model development has been lacking. Read More

View Article
December 2018

Rationale, design, and methods for the Medical Optimization and Management of Pregnancies with Overt Type 2 Diabetes (MOMPOD) study.

BMC Pregnancy Childbirth 2018 Dec 12;18(1):488. Epub 2018 Dec 12.

The University of North Carolina at Chapel Hill School of Medicine, Campus Box 7516, Chapel Hill, NC, 27599-7516, USA.

Background: Annually in the US, over 100,000 pregnant women with overt type 2 diabetes give birth. Strict maternal glycemic control is the key to optimizing infant outcomes. Medical treatment of type 2 diabetes in pregnancy is generally restricted to insulin, as data on the safety and efficacy of oral hypoglycemic agents in pregnancy are limited. Read More

View Article
December 2018

Aberrant structural and functional connectivity and neurodevelopmental impairment in preterm children.

J Neurodev Disord 2018 Dec 13;10(1):38. Epub 2018 Dec 13.

Departments of Neurology, Pediatrics and Mallinckrodt Institute of Radiology, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8111, St. Louis, MO, 63110, USA.

Background: Despite advances in antenatal and neonatal care, preterm birth remains a leading cause of neurological disabilities in children. Infants born prematurely, particularly those delivered at the earliest gestational ages, commonly demonstrate increased rates of impairment across multiple neurodevelopmental domains. Indeed, the current literature establishes that preterm birth is a leading risk factor for cerebral palsy, is associated with executive function deficits, increases risk for impaired receptive and expressive language skills, and is linked with higher rates of co-occurring attention deficit hyperactivity disorder, anxiety, and autism spectrum disorders. Read More

View Article
December 2018

Changes in the Prevalence of Embryologic Remnants in Umbilical Cord With Gestational Age.

Pediatr Dev Pathol 2018 Dec 12:1093526618813663. Epub 2018 Dec 12.

2 Department of Clinical Genetics, Lund University, Lund, Sweden.

The aim of this study was to examine the prevalence of embryologic remnants in umbilical cords of different gestational ages. Sections from 392 umbilical cords were examined using light microscopy. Of these, 52% contained at least 1 remnant, most commonly of the allantoic duct type. Read More

View Article
December 2018

Cytokine Changes in Maternal Peripheral Blood Correlate With Time-to-Delivery in Pregnancies Complicated by Premature Prelabor Rupture of the Membranes.

Reprod Sci 2018 Dec 12:1933719118815590. Epub 2018 Dec 12.

2 Lunenfeld-Tanenbaum Research Institute at Mount Sinai Hospital, Toronto, Ontario, Canada.

Premature prelabor rupture of the membranes (PPROM) causes one-third of preterm births worldwide and is most likely caused by subclinical intrauterine infection and/or inflammation. We proposed that women with systemic inflammation at the time of PPROM would have shorter latency. Peripheral blood samples were collected from 20 singleton pregnant women with PPROM between 23 ± 1 and 33 ± 6 weeks. Read More

View Article
December 2018

Use and experiences with external fetal monitoring devices among obstetrical providers.

J Matern Fetal Neonatal Med 2018 Dec 12:1-6. Epub 2018 Dec 12.

a Department of Obstetrics and Gynecology , The Ohio State University College of Medicine , Columbus , OH , USA.

Introduction: Fetal heart rate monitoring presents one of the few available methods for evaluating the fetus prior to birth. However, current devices on the market have significant shortcomings. We sought to describe the use and experiences with external fetal monitoring (EFM) devices among obstetrical providers. Read More

View Article
December 2018

Primary Prevention of Airway Allergy.

Curr Treat Options Allergy 2018 5;5(4):347-355. Epub 2018 Nov 5.

1Skin and Allergy Hospital, Helsinki University Central Hospital, Meilahdentie 2, 00250 Helsinki, Finland.

Purpose Of Review: The aim of this paper is to review and summarize the current knowledge of prevention of airway allergy.

Recent Findings: Allergic rhinitis and asthma are allergic airway diseases. Due to their increasing incidence and socioeconomic burden, allergic airway diseases have recently gained attention worldwide. Read More

View Article
November 2018

Associations between gestational weight gain and rate of infancy weight gain in Hawai'i and Puerto Rico WIC participants.

BMC Obes 2018 3;5:41. Epub 2018 Dec 3.

1Department of Human Nutrition, Food and Animal Sciences, College of Tropical Agriculture and Human Resources, University of Hawai'i at Mānoa. Agricultural Sciences 216, 1955 East-West Rd, Honolulu, HI 96822 USA.

Background: Excessive gestational weight gain and rapid infancy weight gain (RIWG) are associated with increased susceptibility to childhood obesity. Since low-income and minority children are particularly at risk, investigation of the associations between gestational weight gain and rate of infancy weight gain may inform childhood obesity prevention. This study investigated the associations between gestational weight gain and rate of infancy weight gain during the first four to six months postpartum in participants from the Special Supplemental Nutrition Program for Women, Infants, and Children (WIC) in Hawai'i and Puerto Rico. Read More

View Article
December 2018

Comparing Different Diagnostic Guidelines for Gestational Diabetes Mellitus in Relation to Birthweight in Sri Lankan Women.

Front Endocrinol (Lausanne) 2018 15;9:682. Epub 2018 Nov 15.

Division of O&G, KK Women's and Children's Hospital, Singapore, Singapore.

While the International Association of Diabetes and Pregnancy Study Groups (IADPSG) criteria is widely adopted in many countries, clinicians have questioned the applicability of these diagnostic thresholds for different races/ethnicities. We first compared the prevalence of gestational diabetes mellitus (GDM) diagnosed with different criteria including IADPSG, World Health Organization (WHO) 1999 and Sri Lankan national guidelines, and subsequently related individual guidelines-specific GDM prevalence to offspring birthweight in Sri Lanka. We retrospectively collected data on singleton pregnancies ( = 795) from two tertiary hospitals in Sri Lanka. Read More

View Article
November 2018

Family History of Diabetes Is Associated With Delayed Fetal Postprandial Brain Activity.

Front Endocrinol (Lausanne) 2018 20;9:673. Epub 2018 Nov 20.

Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Center Munich at the University of Tübingen, Tübingen, Germany.

We have previously shown that fetuses of mothers with gestational diabetes mellitus (GDM) and insulin resistance exhibit a prolongation of fetal auditory event-related brain responses (fAER) compared to fetuses of normal glucose tolerant women during an oral glucose tolerance test (oGTT). This implies that maternal metabolism may program the developing fetal brain. We now asked whether a family history of type 2 diabetes without metabolic programing also impacts fetal brain activity. Read More

View Article
November 2018

Neurofilament Light Chain: Blood Biomarker of Neonatal Neuronal Injury.

Front Neurol 2018 20;9:984. Epub 2018 Nov 20.

Department of Neonatology, University Children's Hospital Basel, University of Basel, Basel, Switzerland.

Neurofilament light chain (NfL) is a highly promising biomarker of neuroaxonal injury that has mainly been studied in adult neurodegenerative disease. Its involvement in neonatal disease remains largely unknown. Our aim was to establish NfL plasma concentrations in preterm and term infants in the first week of life. Read More

View Article
November 2018

Supine vs. Prone Position With Turn of the Head Does Not Affect Cerebral Perfusion and Oxygenation in Stable Preterm Infants ≤32 Weeks Gestational Age.

Front Physiol 2018 22;9:1664. Epub 2018 Nov 22.

Department of Pediatrics, University Hospital Schleswig-Holstein, Kiel, Germany.

Intraventricular hemorrhage (IVH) is a frequent major damage to the brain of premature babies ≤32 weeks gestational age, and its incidence (20-25%) has not significantly changed lately. Because of the intrinsic fragility of germinal matrix blood vessels, IVH occurs following disruption of subependymal mono-layer arteries and is generally attributed to ischemia-reperfusion alterations or venous congestion, which may be caused by turn of the head. Therefore, supine position with the head in a midline position is considered a standard position for preterm infants during their first days of life. Read More

View Article
November 2018

Giving Birth After Fertility Sparing Treatment of Embrional Carcinoma Figo III C: Case Report and Literature Review.

Med Arch 2018 Nov;72(5):371-373

Department for Pathology, Policlinic for Laboratory Diagnostic, University Clinical Center Tuzla, Tuzla, Bosnia and Herzegovina.

Introduction: Malignant ovarian germ cell tumors (MOGCTs) account for 2-5% of all ovarian cancers and among them pure embryonal cell cancer is rare condition (1, 2, 3, 4).

Aim: To show successful pregnancy after unilateral salpingooopherectomy and chemotherapy in a girl with embryonal carcinoma of ovary (ECO).

Case Report: Patient had FIGO stage III c disease. Read More

View Article
November 2018

Effect of Lifestyle Coaching Including Telemonitoring and Telecoaching on Gestational Weight Gain and Postnatal Weight Loss: A Systematic Review.

Telemed J E Health 2018 Dec 6. Epub 2018 Dec 6.

1 Faculty of Health and Social Work, Research Unit Healthy Living, University Colleges Leuven-Limburg , Genk, Belgium .

Background: Obesity during pregnancy, excessive gestational weight gain (GWG), and postpartum weight retention (PPWR) are associated with health risks for mothers and their offspring. Face-to-face lifestyle interventions can reduce GWG and PPWR, but they are resource-demanding and effects on long-term maternal and fetal outcomes are scarce.

Objectives: To explore the existing literature about the effect of technology-supported lifestyle interventions including telemonitoring and-coaching on GWG and PPWR. Read More

View Article
December 2018

Variation in outcome reporting in randomised controlled trials of interventions for the prevention and treatment of fetal growth restriction.

Ultrasound Obstet Gynecol 2018 Dec 6. Epub 2018 Dec 6.

Fetal Medicine Unit, St George's University Hospitals NHS Foundation Trust, London, UK.

Background: Fetal growth restriction (FGR) contributes to stillbirth, prematurity, neonatal and infant mortality and morbidity. Although FGR is well known to be associated with adverse outcomes for the mother and offspring, effective interventions for the prevention of FGR are yet to be established. The majority of pregnancies complicated by FGR are not detected antenatally and there are limited effective interventions for established FGR. Read More

View Article
December 2018

Gestational diabetes mellitus alters DNA methylation profiles in pancreas of the offspring mice.

J Diabetes Complications 2018 Nov 9. Epub 2018 Nov 9.

Department of Endocrinology, Shengli Clinical Medical College of Fujian Medical University, Fuzhou, Fujian, China; Department of Scientific Research, Fujian Academy of Medical Sciences, Fuzhou, Fujian, China. Electronic address:

Gestational diabetes mellitus (GDM), which has an increasing global prevalence, contributes to the susceptibility to metabolic dysregulation and obesity in the offspring via epigenetic modifications. However, the underlying mechanism remains largely obscure. The current study established a GDM mice model to investigate the alternations in the metabolic phenotypes and genomic DNA methylation in the pancreas of the offspring. Read More

View Article
November 2018

Electronic Algorithm Is Superior to Hospital Discharge Codes for Diagnoses of Hypertensive Disorders of Pregnancy in Historical Cohorts.

Mayo Clin Proc 2018 Dec;93(12):1707-1719

Division of Nephrology and Hypertension, University of Belgrade, Belgrade, Serbia; Department of Obstetrics and Gynecology, Mayo Clinic College of Medicine and Science, Mayo Clinic, Rochester, MN. Electronic address:

Objectives: To develop and validate criteria for the retrospective diagnoses of hypertensive disorders of pregnancy that would be amenable to the development of an electronic algorithm, and to compare the accuracy of diagnoses based on both the algorithm and diagnostic codes with the gold standard, of physician-made diagnoses based on a detailed review of medical records using accepted clinical criteria.

Patients And Methods: An algorithm for hypertensive disorders of pregnancy was developed by first defining a set of criteria for retrospective diagnoses, which included relevant clinical variables and diagnosis of hypertension that required blood pressure elevations in greater than 50% of readings ("the 50% rule"). The algorithm was validated using the Rochester Epidemiology Project (Rochester, Minnesota). Read More

View Article
December 2018

Proportion and factors of death among preterm neonates admitted in University of Gondar comprehensive specialized hospital neonatal intensive care unit, Northwest Ethiopia.

BMC Res Notes 2018 Dec 6;11(1):867. Epub 2018 Dec 6.

Department of Health Economics, Institute of Public Health, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.

Objective: Neonatal mortality accounts for 43% of under-five child mortality in Ethiopia where preterm is the second leading cause of neonatal death and steadily increased in low-income countries. Therefore, assessing the proportion of death and associated factors among preterm neonates has a paramount importance in designing an effective strategy to intervene and achieve sustainable development goal.

Results: In this study proportion of preterm neonatal death in this study was 28. Read More

View Article
December 2018

Risk factors for hypertensive disorders of pregnancy among mothers in Tigray region, Ethiopia: matched case-control study.

BMC Pregnancy Childbirth 2018 Dec 6;18(1):482. Epub 2018 Dec 6.

School of Public Health, Addis Ababa University, Addis Ababa, Ethiopia.

Background: Hypertensive disorders of pregnancy are a global public health concern both in developed and developing countries. However, evidences regarding the risk factors of hypertensive disorders of pregnancy are limited particularly in Ethiopia. The aim of the study was to assess risk factors associated with hypertensive disorders of pregnancy among mothers in public hospitals of Tigray. Read More

View Article
December 2018

Association between Dietary Glycemic Index and Excess Weight in Pregnant Women in the First Trimester of Pregnancy.

Rev Bras Ginecol Obstet 2018 Dec 12. Epub 2018 Dec 12.

Group of Research in Nutrition and Chronic Diseases, Universidade Estadual do Ceará, Fortaleza, CE, Brazil.

Objective:  To assess the association between dietary glycemic index (GI) and excess weight in pregnant women in the first trimester of pregnancy.

Methods:  A cross-sectional study in a sample of 217 pregnant women was conducted at the maternal-fetal outpatient clinic of the Hospital Geral de Fortaleza, Fortaleza, state of Ceará, Brazil, for routine ultrasound examinations in the period between 11 and 13 weeks + 6 days of gestation. Weight and height were measured and the gestational body mass index (BMI) was calculated. Read More

View Article
December 2018
6 Reads

Apgar Scoring System in Brazil's Live Births Records: Differences between Home and Hospital Births.

Rev Bras Ginecol Obstet 2018 Dec 12. Epub 2018 Dec 12.

Department of Radiology and Oncology, Universidade de São Paulo, São Paulo, SP, Brazil.

Objective:  To promote informed choice for women and to compare home and hospital births in relation to the Apgar score.

Methods:  Mother's profile and Apgar score of naturally born infants (without forceps assistance) in Brazil between 2011 and 2015, in both settings-hospital or home-were collected from live birth records provided by the Informatics Department of the Unified Health System (DATASUS, in the Portuguese acronym). For the analysis, were included only data from low-risk deliveries, including gestational time between 37 and 41 weeks, singleton pregnancy, at least four visits of prenatal care, infants weighing between 2,500 g, and 4,000 g, mother age between 20-40 years old, and absence of congenital anomalies. Read More

View Article
December 2018
1 Read

Ruptured Renal Artery Aneurysm in a Pregnant Woman: Case Report and Literature Review.

Rev Bras Ginecol Obstet 2018 Dec 12. Epub 2018 Dec 12.

Universidade Positivo, Curitiba, PR, Brazil.

Renal artery aneurysms (RAAs) are rare and usually asymptomatic; ∼ 90% of them are unilateral. Once diagnosed during pregnancy, they may rupture, presenting a high maternal-fetal risk. The present study reports the case of a 32-year-old pregnant woman with a 30-week gestational age and a ruptured unilateral RAA. Read More

View Article
December 2018
1 Read

Letter to the Editor: Gestational Gigantomastia Complicated by PTHrP-mediated Hypercalcemia.

J Clin Endocrinol Metab 2018 Dec 11. Epub 2018 Dec 11.

Center for Bone Quality: Department of Internal Medicine: division of Endocrinology, Leiden University Medical Center, Leiden, the Netherlands.

View Article
December 2018

Impact of surfactant administration through a thin catheter in the delivery room: A quality control chart analysis coupled with a propensity score matched cohort study in preterm infants.

PLoS One 2018 12;13(12):e0208252. Epub 2018 Dec 12.

Department of Pediatrics, University of Rennes 1,Rennes, France.

Introduction: Most infants born before 30 weeks gestational age (GA) develop respiratory distress syndrome soon after birth. Methods of surfactant administration that avoid ventilation have been recently introduced. The aim of this study was to evaluate the impact of implementing a new procedure of less invasive surfactant administration (LISA) and determine whether it is associated with an improvement in respiratory outcome. Read More

View Article
December 2018

Relationship between amikacin blood concentration and ototoxicity in low birth weight infants.

J Infect Chemother 2019 Jan 24;25(1):17-21. Epub 2018 Oct 24.

Department of Pharmacy, Yamanashi Prefectural Central Hospital, Yamanashi, 400-8506, Japan.

Amikacin (AMK) is used as empiric therapy for severe infections such as sepsis in low birth weight (LBW) infants. AMK administered once daily (OD) in adults is reported to be therapeutically effective and prevent side effects, however, evidence on AMK administration in LBW infants is limited, with no clear indications of effectiveness. We performed therapeutic drug monitoring analysis of 20 infants treated with AMK OD for severe infections such as bacteremia. Read More

View Article
January 2019

Previous Adverse Outcome of Term Pregnancy and Risk of Preterm Birth in Subsequent Pregnancy.

Matern Child Health J 2018 Dec 11. Epub 2018 Dec 11.

The California Preterm Birth Initiative, University of California, San Francisco, San Francisco, CA, USA.

Objective Evaluate risk of preterm birth (PTB, < 37 completed weeks' gestation) among a population of women in their second pregnancy with previous full term birth but other adverse pregnancy outcome. Methods The sample included singleton live born infants between 2007 and 2012 in a birth cohort file maintained by the California Office of Statewide Health Planning and Development. The sample was restricted to women with two pregnancies resulting in live born infants and first birth between 39 and 42 weeks' gestation. Read More

View Article
December 2018

Th1/Th2 Dichotomy in Obese Women with Gestational Diabetes and Their Macrosomic Babies.

J Diabetes Res 2018 14;2018:8474617. Epub 2018 Nov 14.

Laboratory of Physiology and Functional Explorations, Faculty of Medicine, Pharmacy and Odontology, Cheikh Anta Diop University, 5005 Dakar-Fann, Senegal.

The aim of the study was to assess T cell differentiation and the modulation of inflammatory cytokines in obese and gestational diabetes mellitus (GDM) women and their macrosomic newborns. Hence, immediately after delivery, blood samples were collected through the mother's arm vein and the umbilical cordon vein. Biochemical parameters measured were HbA1C, glucose, insulin, triglyceride (TG), total cholesterol (Tchol), HDL cholesterol (HDLchol), and LDL cholesterol (LDLchol). Read More

View Article
November 2018
1 Read