11,419 results match your criteria Germinoma Central Nervous System


Long-term follow-up of intensive chemotherapy followed by reduced-dose and reduced-field irradiation for intracranial germ cell tumor.

Authors:

J Neurosurg Pediatr 2018 Nov 1:1-8. Epub 2018 Nov 1.

OBJECTIVEThe authors analyzed the efficacy of intensive chemotherapy followed by reduced-dose and reduced-field irradiation for intracranial germ cell tumors (GCTs) and evaluated the long-term late effects caused by chemoradiotherapy (CRT).METHODSThe authors performed a retrospective study. The subjects were 24 patients who received CRT between April 1994 and April 2015. Read More

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November 2018

Bromocriptine-responsive supersellar germinoma with the expression of dopamine receptors: A case report.

Clin Neurol Neurosurg 2018 Nov 10;176:15-18. Epub 2018 Nov 10.

Department of Neurosurgery, Center of Pituitary Tumor, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197# Ruijin Er Road, Shanghai, 200025, China. Electronic address:

Background: Germinomas are sensitive to radiotherapy and chemotherapy. However, there has been no report involving in the potential therapeutic effect of dopamine agonists (DAs) such as bromocriptine on germinomas.

Case Description: A 20-year-old female was presented with bitemporal visual disturbance and amenorrhea. Read More

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November 2018
3 Reads

Fast-developing fatal diffuse leptomeningeal dissemination of a pineal germinoma in a young child: a case report and literature review.

Br J Neurosurg 2018 Nov 19:1-8. Epub 2018 Nov 19.

a Department of Neurosurgery , West China Hospital, Sichuan University , Chengdu , Sichuan 610041 , China.

Background: Intracranial germinomas are uncommon and constitute less than 1% of all intracranial tumors. They usually arise in the midline of the brain, most commonly in the pineal region. Pineal germinomas tend to spread through the cerebrospinal fluid (CSF). Read More

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November 2018
2 Reads

Unusual presentation of epilepsy of germinoma located in the frontal-lobe: case report and literature review.

Br J Neurosurg 2018 Nov 19:1-3. Epub 2018 Nov 19.

a Department of Neurosurgery , The First Affiliated Hospital of Zhengzhou University , ZhengZhou , HeNan Province , PR China.

Germinoma is rare in peripheral lobar locations in the brain, with only 10 cases of primary frontal lobe germinoma having been reported in the previous literature. Epilepsy is a rare manifestation of germinomas. We describe an unusual case of a primary frontal germinoma in a 21-year-old man who presented with epilepsy. Read More

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November 2018
2 Reads

Secondary glioblastoma after treatment of intracranial germinoma - would radiation-only therapy still be safe? Case report.

BMC Cancer 2018 Nov 16;18(1):1119. Epub 2018 Nov 16.

Department of Neurosurgery, Seoul National University Bundang Hospital, 82, Gumi-ro 173 Beon-gil, Bundang-gu, Seongnam-si, Gyeonggi-do, 13620, Republic of Korea.

Back Ground: Intracranial germinomas are one of the most radiosensitive tumors and are curable by radiotherapy (RT) alone. RT-only therapy without chemotherapy is effective. But, as patients with germinoma can expect long-term survival, the adverse effects of RT and late sequelae in survivors are of most concern. Read More

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November 2018
2 Reads

Diagnostic radiation-induced regression of a metastatic primary intracranial germinoma: a case report.

Br J Neurosurg 2018 Nov 4:1-4. Epub 2018 Nov 4.

a Department of Neurosurgery , Kwong Wah Hospital , Yaumatei , Hong Kong.

Pineal region germinomas are sensitive to radiotherapy. Standard neurosurgical management involves obtaining a tissue biopsy and to relieve the often accompanying obstructive hydrocephalus. We present a patient with a suspected hyper-radiosensitive metastatic primary intracranial germinoma where computed tomography scanning resulted in tumor regression before radiotherapy could be administered. Read More

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November 2018
2 Reads

Re-irradiation for Paediatric Tumours.

Clin Oncol (R Coll Radiol) 2018 Oct 29. Epub 2018 Oct 29.

Radiation Medicine Program, Princess Margaret Cancer Centre, University Health Network, Toronto, Canada; Department of Radiation Oncology, University of Toronto, Toronto, Canada.

Despite best available therapy, many children with cancer develop recurrence after multimodal treatment, including initial radiation therapy. Re-irradiation is defined as the use of a second course of radiation therapy with a retreatment volume that overlaps substantially with that of a previously delivered course of radiation therapy. Re-irradiation is an important part of salvage treatment for patients with recurrent ependymoma, diffuse intrinsic pontine glioma, medulloblastoma and germinoma. Read More

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October 2018
2 Reads

Pineal and Suprasellar Germinoma Cooccurence with Vertebra Plana: A Case Report.

Brain Tumor Res Treat 2018 Oct;6(2):73-77

Department of Neurosurgery, Mashhad University of Medical Sciences, Mashhad, Iran.

Germinoma is the most common type of intracranial germ cell tumors (GCTs). Pineal gland and suprasellar region are the most frequent sites of central nervous system (CNS) involvement. Intracranial masses caused by Langerhans cell histiocytosis (LCH) mimics features of CNS GCTs. Read More

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October 2018
3 Reads

Clinical case seminar: Familial intracranial germinoma.

Endokrynol Pol 2018 ;69(5):612-618

Clinic for Endocrinology, Diabetes and Metabolic Diseases, Clinical Centre of Serbia, Belgrade, Serbia, Serbia and Montenegro; University of Belgrade, School of Medicine, Belgrade, Serbia.

Background: Intracranial germinomas (ICG) are uncommon brain neoplasms with extremely rare familial occurance. Since ICG invades hypothalamus and/or pituitary, the endocrine dysfunction is one of the common determinants of these tumors. We presented two brothers with the history of ICG. Read More

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January 2018
7 Reads

Delays in Diagnosis of Pediatric Histologically Confirmed Sellar Germ Cell Tumors in China: A Retrospective Risk Factor Analysis.

World Neurosurg 2018 Oct 24. Epub 2018 Oct 24.

Department of Neurosurgery, Peking Union Medical College Hospital, Beijing, China. Electronic address:

Background: Sellar germ cell tumors (GCTs) occur more frequently in childhood. Some will present as malignancy with infiltration and metastasis. However, the association between the timeliness of diagnosis and outcome has been controversial. Read More

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October 2018
6 Reads
2.420 Impact Factor

Bilateral optic neuropathy with central diabetes insipidus in a child.

Indian J Ophthalmol 2018 Nov;66(11):1642-1644

Institute of Neuroscience, SIMS Hospitals, Chennai, Tamil Nadu, India.

Central nervous system germ cell tumors are rare and they occur in the first two decades of life. Optic nerve germinomas can sometimes mimic optic nerve inflammation. In this case report, we discuss an 11-year-old girl who presented with features of presumed bilateral optic neuritis and developed polyuria and polydipsia, subsequently she was diagnosed to have infiltrative etiology. Read More

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November 2018
1 Read

A systematic review of shunt-related extraneural metastases of primary central nervous system tumors.

Clin Neurol Neurosurg 2018 Nov 27;174:239-243. Epub 2018 Sep 27.

Department of Neurosurgery, University of North Carolina School of Medicine, Chapel Hill, North Carolina, United States. Electronic address:

Extraneural metastasis (ENM) of primary central nervous system (CNS) tumors is an uncommon occurrence. Case reports and case series describe ENM after shunting, but this phenomenon has not been well characterized. In this review we aim to better understand the risk factors and clinical implications of ENM associated with shunting. Read More

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November 2018
9 Reads

Ultrasonographic features of testicular metastasis from renal clear cell carcinoma that mimics a seminoma: A case report.

Medicine (Baltimore) 2018 Oct;97(40):e12728

Department of Ultrasound, West China Hospital, Sichuan University, Chengdu, Sichuan, China.

Rationale: Testicular metastases from renal cell carcinoma (RCC) are extremely rare. To the best of our knowledge, only 35 cases have been described in the literatures.

Patient Concerns: A 64-year-old male presented to our urology clinic for a palpable painless mass on his right side of the scrotum by self-examination 1 week ago, with a general abdominal ultrasonographic report showing a mass in his right kidney. Read More

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October 2018
2 Reads

Placental alkaline phosphatase levels in cerebrospinal fluid can have a decisive role in the differential diagnosis of intracranial germ cell tumors.

J Neurosurg 2018 Sep 28:1-8. Epub 2018 Sep 28.

Department of Neurosurgery, Tokyo Women's Medical University, Tokyo.

Objective: Placental alkaline phosphatase (PLAP) in CSF can provide a very high diagnostic value in cases of intracranial germ cell tumors (GCTs), especially in pure germinomas, to the level of not requiring histological confirmation. Unlike other tumor markers, reliable data analysis with respect to the diagnostic value of PLAP serum or CSF levels has not been available until now. This is the first systematic and comprehensive study examining the diagnostic value of CSF PLAP in patients with intracranial GCTs. Read More

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September 2018
7 Reads

Classic and "Dissecting" Gonadoblastoma in a Phenotypic Girl With a 46, XX Peripheral Karyotype and No Evidence of a Disorder of Sex Development.

Int J Gynecol Pathol 2018 Sep 24. Epub 2018 Sep 24.

Department of Pathology, Indiana University School of Medicine, Indianapolis, Indiana (L.M.R.) Spectrum Health, Grand Rapids, Michigan (M.M.D.) Patho-Lab Diagnostics, Nes-Ziona, Israel (B.C.).

Herein, we report a case of a 9-yr-old girl who had a 46, XX peripheral karyotype and apparent developmentally normal ovaries. She presented with abdominal pain and a right adnexal mass. No clinical or pathologic evidence of gonadal dysgenesis or undifferentiated gonadal tissue was detected. Read More

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September 2018
2 Reads

Null Cell Adenoma of the Pituitary: Pseudo-rosettes Say It Best When Immunohistochemistry Says Nothing At All!

Head Neck Pathol 2018 Sep 24. Epub 2018 Sep 24.

Department of Neurosurgery, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.

Null cell adenoma is composed of adenohypophyseal cells that show no evidence of any specific cell type differentiation by immunohistochemistry or transcription factors like pituitary-specific positive transcription factor 1 and steroidogenic factor 1. Though rare, pituitary ependymoma and germinoma are also known to occur at sellar region and in such instances, it is challenging to differentiate them from a pituitary null cell adenoma featuring papillary architecture and perivascular pseudo-rosettes. We describe a case of an elderly diabetic lady presenting with headache and blurring of vision for past 3 months due to a sellar tumour. Read More

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September 2018

Treatment outcomes of intracranial germinoma: a retrospective analysis of 170 patients from a single institution.

J Cancer Res Clin Oncol 2018 Sep 12. Epub 2018 Sep 12.

Department of Radiation Oncology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 1 Shuaifuyuan Wangfujing Dongcheng District, Beijing, China.

Purpose: To perform a retrospective analysis of patients with intracranial germinoma treated in our department to evaluate treatment outcomes and determine optimal treatment strategies.

Methods: We reviewed the treatment outcomes of 170 patients with intracranial germinoma who were treated in our department from January 1996 to January 2017. The median patient age was 15 years old. Read More

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September 2018
2 Reads

A case of bilateral vasculitis associated with pineal germinoma.

Am J Ophthalmol Case Rep 2018 Sep 19;11:142-145. Epub 2018 Jul 19.

Department of Surgery, Division of Ophthalmology, Kobe University Graduate School of Medicine, 7-5-2 Kusunoki-cho, Chuo-ku, Kobe, Hyogo, Japan.

Purpose: To report a rare case of bilateral periphlebitis associated with a pineal germinoma.

Observations: A 17-year-old male teenager presented at a local clinic complaining of blurred vision in both eyes. The treating physician identified bilateral uveitis, and prescribed the patient with a local steroid treatment. Read More

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September 2018

Intracranial Germ Cell Tumors: Spectrum of Disease in an Indian Cohort and Management Strategies.

J Neurosci Rural Pract 2018 Jul-Sep;9(3):291-297

Department of Neuropathology, National Institute of Mental Health and Neurosciences, Bengaluru, Karnataka, India.

Background: Germ cell tumors (GCTs) represent approximately 3% of primary pediatric brain tumors in the West, whereas in Asia, they constitute between 8% and 15% of pediatric brain tumors.

Methods: We retrospectively studied all patients with intracranial GCT managed at our institute from January 1998 to December 2013. The clinical data and radiological data were analyzed. Read More

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August 2018
5 Reads

Spermatocytic seminoma with rhabdomyoblastic differentiation: Case report and review of literature.

Indian J Pathol Microbiol 2018 Jul-Sep;61(3):437-439

Department of Pathology, HBT Medical College and Dr. R. N. Cooper Municipal General Hospital, Mumbai, Maharashtra, India.

Spermatocytic seminoma (SCS) is an indolent germ cell tumor of the testis. It has an excellent prognosis and orchidectomy is generally curative. Very rarely, it can be complicated by a sarcomatous transformation which is associated with a very aggressive behavior and requires adjuvant therapy. Read More

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November 2018
2 Reads

Thalamic germinoma: a challenging diagnosis, case report and literature review.

J Surg Case Rep 2018 Jul 3;2018(7):rjy154. Epub 2018 Jul 3.

Neurosurgery Department, National Neuroscience Institute, King Fahd Medical City, Riyadh, Saudi Arabia.

The thalamus and basal ganglia are unusual locations for an intracranial germ cell tumors. We are reporting a rare case of thalamic germinoma in an 18-year-old male. Challenging presentation, radiological appearance and pathological finding after surgical intervention delayed the diagnosis and treatment. Read More

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July 2018
15 Reads

Response to 'Aberrant expression of TdT in seminomatous germ cell neoplasia'.

Virchows Arch 2018 09 6;473(3):387. Epub 2018 Jul 6.

Institute of Pathology, Justus-Liebig-University, 35392, Giessen, Germany.

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September 2018
5 Reads

Aberrant expression of TdT in seminomatous germ cell neoplasia.

Virchows Arch 2018 09 3;473(3):385-386. Epub 2018 Jul 3.

Department of Pathology, VCU School of Medicine, 1200 E Marshall Street, Gateway 6-205, PO Box 980622, Richmond, VA, 23298, USA.

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September 2018
6 Reads

A Craniopharyngioma Associated With Elevated Cerebrospinal Fluid HCG Concentrations Misdiagnosed as a Germinoma.

Front Neurol 2018 14;9:449. Epub 2018 Jun 14.

Department of Endocrinology, Chinese People's Liberation Army General Hospital, Beijing, China.

Craniopharyngiomas and germinomas are both rare cranial tumors that most commonly present during childhood or adolescence. Although these tumors have different origins, their clinical and radiological features may be similar. In this article, we report the case of a 35-year female patient with clinical and radiological findings and increased human chorionic gonadotrophin (HCG) levels in the cerebrospinal fluid (CSF) that were consistent with a germinoma. Read More

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June 2018
11 Reads

Peritoneal Myeloid Sarcoma in a Patient Treated for a Testicular Seminoma.

Am J Case Rep 2018 Jun 29;19:763-766. Epub 2018 Jun 29.

Division of Medical Oncology, Mercy Hospital, Metz-Thionville Regional Hospital Center, Ars-Laquenexy, France.

BACKGROUND Myeloid sarcoma is a rare extramedullary soft tissue neoplasm composed of myeloblastic cells, usually associated to hematologic tumor disorders and a poor prognosis. Its diagnosis is very difficult as radiological images are not specific. Histology and immunohistochemistry are necessary for an accurate diagnosis. Read More

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June 2018
5 Reads

[Preoperative and postoperative ophthalmic symptoms in patients with space-occupying lesions of the midbrain and pineal region].

Zh Vopr Neirokhir Im N N Burdenko 2018 ;82(3):42-47

Burdenko Neurosurgical Institute, 4-ya Tverskaya-Yamskaya Str., 16, Moscow, Russia, 125047.

The most common clinical manifestations of space-occupying lesions of the midbrain and pineal region are oculomotor and pupil disorders and ophthalmoscopic signs of intracranial hypertension.

Purpose: To identify patterns of neuro-ophthalmic symptoms before and after surgical treatment in patients with space-occupying lesions of the midbrain and pineal region.

Material And Methods: We analyzed neurological symptoms in 231 patients with space-occupying lesions of the midbrain and pineal region before and after surgical treatment. Read More

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January 2018
7 Reads

Suprasellar Germinomas: 2 Case Reports and Literature Review.

World Neurosurg 2018 Sep 15;117:165-171. Epub 2018 Jun 15.

Pathology Institute of Passo Fundo, Passo Fundo, Brazil.

Background: Germinomas are rare malignant central nervous system tumors, a type of germ cell tumor, according to the 2016 World Health Organization Classification of Brain Tumors. Most of these tumors develop along the midline, most often from the pineal gland, followed by tumors arising in the suprasellar cisterns. Suprasellar germinomas commonly manifest with diabetes insipidus, visual impairment, and hypothalamic-pituitary failure. Read More

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September 2018
8 Reads

Retroperitoneal seminoma, a rare cause of testicular pain.

BMJ Case Rep 2018 Jun 14;2018. Epub 2018 Jun 14.

Department of General Surgery, Royal Free London NHS Foundation Trust, London, London, UK.

Extragonadal retroperitoneal seminomas are a rare cause of testicular pain in males. We report the case of a 46-year-old man, who presented with right-sided testicular pain, clinically mimicking testicular torsion. The patient underwent a scrotal exploration, which revealed normal testes. Read More

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June 2018
3 Reads

Neuropsychological Consequences for Survivors of Childhood Brain Tumor in Malaysia.

Front Psychol 2018 29;9:703. Epub 2018 May 29.

Department of Clinical Child and Adolescent Studies, Faculty of Social Sciences, Leiden University, Leiden, Netherlands.

This study aimed to evaluate neuropsychological consequences in survivors of childhood brain tumor. A case-control study was conducted over a period of 4 months in a tertiary referral center in Kuala Lumpur, Malaysia. Fourteen survivors of childhood brain tumor aged 7-18 years, who were off-treatment for at least 1 year and were in remission, and 31 unrelated healthy controls were recruited. Read More

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May 2018
8 Reads

[Thickening of the pituitary stalk in children and adolescents with central diabetes insipidus: Causes and consequences].

An Pediatr (Barc) 2018 Jun 9. Epub 2018 Jun 9.

Servicio de Pediatría y Endocrinología, Hospital Infantil Universitario Niño Jesús, Madrid, España; Departamento de Pediatría, Universidad Autónoma de Madrid, Madrid, España; CIBER Fisiopatología de la Obesidad y Nutrición, Instituto de Salud Carlos III, Madrid, España.; IMDEA Instituto de Alimentación, CEI UAM + CSIC, Madrid, España.

Background: Central diabetes insipidus (CDI) is a rare disorder in children. The aetiology of CDI in childhood is heterogeneous. The aim of this study is to illustrate the importance of a careful clinical and neuro-radiological follow-up of the pituitary and hypothalamus region in order to identify the aetiology and the development of associated hormonal deficiencies. Read More

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June 2018
4 Reads

Is carboplatin-based chemotherapy as effective as cisplatin-based chemotherapy in the treatment of advanced-stage dysgerminoma in children, adolescents and young adults?

Gynecol Oncol 2018 08 5;150(2):253-260. Epub 2018 Jun 5.

Children's and Young Persons Cancer Services, University College London Hospital Trusts, London, UK.

Objective: Dysgerminoma is the most common malignant ovarian germ cell tumor (GCT) with peak incidence during adolescence and young adulthood. Current standard of care for patients with disease that has spread outside of the ovary (advanced-stage) utilizes platin-based chemotherapy regimens. The study objective was to compare clinical outcomes between platin-based (carboplatin versus cisplatin) strategies across all age groups (children < 11 years (y), adolescents = 11-25 y and young adult women > 25 y) for advanced-stage dysgerminoma. Read More

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August 2018
3 Reads

A rare subtype of meningioma: Case series of anaplastic meningioma and review of the literature.

Medicine (Baltimore) 2018 Jun;97(23):e11019

Department of Pathology, First Affiliated Hospital and College of Basic Medical Sciences of China Medical University.

Rationale: Anaplastic meningioma, a rare subtype of meningioma, has malignant morphological characteristics and a World Health Organization (WHO) grade of III.

Patient Concerns: In this report, we present findings from 6 cases of anaplastic meningioma.

Diagnoses: Pathological examination of the tumors, including hematoxylin and eosin staining and immunohistochemical staining, was performed. Read More

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June 2018
3 Reads
5.720 Impact Factor

Central Nervous System Germ Cell Tumors: A Review of the Literature.

J Child Neurol 2018 Aug 30;33(9):610-620. Epub 2018 May 30.

1 Department of Neurosurgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Central nervous system germ cell tumors are rare intracranial tumors that mainly occur in pediatrics with substantial variation in the incidence among different regions and genders. Histologically, central nervous system germ cell tumors can be divided into germinomas and nongerminomatous germ cell tumors. The molecular pathology of central nervous system germ cell tumors, particularly germinomas, is mainly based on the presence of isochromosome 12p, gain-of-function of the KIT gene, and a globally low DNA methylation profile. Read More

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August 2018
5 Reads

[A Case of Ventriculoperitoneal Shunt Dysfunction in an Adult Secondary to Constipation].

No Shinkei Geka 2018 May;46(5):385-389

Department of Neurosurgery, Tohoku University Graduate School of Medicine.

Introduction: Ventriculoperitoneal(VP)shunts function because of the pressure differential between the intracranial space and the peritoneal cavity. Although chronic constipation is often a cause of VP shunt dysfunction in children, it is not well recognized in adults. We present a case of shunt dysfunction that not only resolved after resolution of constipation but also resulted in overdrainage. Read More

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Unilateral paraneoplastic optic disc edema and retinal periphlebitis in pineal germinoma.

Am J Ophthalmol Case Rep 2018 Jun 13;10:236-239. Epub 2018 Mar 13.

Koc University School of Medicine, Department of Ophthalmology, Istanbul, Turkey.

Purpose: To describe a unilateral ocular paraneoplastic syndrome in pineal germinoma.

Observations: A 24-year-old male presented with diplopia, excessive thirst, and frequent urination. Cranial MRI showed a mass in pineal gland. Read More

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Intracranial Germ Cell Tumor in the Molecular Era.

J Korean Neurosurg Soc 2018 May 1;61(3):333-342. Epub 2018 May 1.

Division of Pediatric Neurosurgery, Seoul National University Children's Hospital, Seoul National University College of Medicine, Seoul, Korea.

Intracranial germ cell tumors (iGCTs) are a heterogeneous group of tumors with peculiar characteristics clearly distinguished from other brain tumors of neuroepithelial origin. Diverse histology, similarity to gonadal GCT, predilection to one sex, and geographic difference in incidence all present enigmas and fascinating challenges. The treatment of iGCT has advanced for germinoma to date; thus, clinical attention has shifted from survival to long-term quality of life. Read More

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Prognostic impact of bleomycin pulmonary toxicity on the outcomes of patients with germ cell tumors.

Med Oncol 2018 Apr 26;35(6):80. Epub 2018 Apr 26.

Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science, 2-5-1, Shikata-cho, Kita-ku, Okayama, 700-8558, Japan.

Bleomycin pulmonary toxicity (BPT) has been well described in patients with germ cell tumors treated with bleomycin etoposide and cisplatin chemotherapy (BEP). To assess the prognostic impact of BPT, we retrospectively identified 52 patients who underwent bleomycin etoposide and cisplatin chemotherapy from 2008 to 2017 in our institution, and evaluated the risk factors of BPT and its effect on prognosis. Patients who had received chemotherapy at another institution were excluded. Read More

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April 2018
1 Read

High-dose chemotherapy with autologous stem cell transplantation spares re-irradiation for recurrent intracranial germinoma.

Pediatr Blood Cancer 2018 Aug 25;65(8):e27104. Epub 2018 Apr 25.

Department of Human Health Sciences, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

The clinical outcome of high-dose chemotherapy (HDC) with autologous stem cell transplantation was retrospectively analyzed in six patients with recurrent intracranial germinoma. Prior to HDC, all patients achieved complete remission after platinum and ifosfamide-based chemotherapy. A melphalan-based conditioning regimen was administered in either a single cycle or multiple sequential cycles. Read More

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August 2018
5 Reads

Capsuloganglionic Germinoma: A Rare Site for Uncommon Childhood Tumor.

Asian J Neurosurg 2018 Apr-Jun;13(2):492-495

Department of Neurosurgery, SGPGIMS, Lucknow, Uttar Pradesh, India.

Germ cell tumors (GCTs) are rare intracranial tumors with a strong predilection for children. Commonly, these tumors arise either in the suprasellar or the pineal region. The basal ganglia-thalamus complex represents a rare site of nonmidline intracranial GCTs. Read More

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April 2018
6 Reads

Widespread Intra-abdominal Carcinomatosis from a Rhabdoid Meningioma after Placement of a Ventriculoperitoneal Shunt: A Case Report and Review of the Literature.

Asian J Neurosurg 2018 Apr-Jun;13(2):386-393

Department of Neurosurgery, University Surgical Cluster, National University Hospital, Singapore.

Intra-abdominal metastasis (IAM) of central nervous system (CNS) tumors through ventriculoperitoneal shunt (VPS) is rare but has been previously reported (e.g., germinomas and medulloblastomas). Read More

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April 2018
1 Read

Spontaneous rupture of seminoma in undescended testis with hemoperitoneum: a rare presentation.

BMJ Case Rep 2018 Apr 19;2018. Epub 2018 Apr 19.

General Surgery, Vardhman Mahavir Medical College, Safdarjung Hospital, New Delhi, Delhi, India.

Cryptorchidism is associated with increased risk of malignancy and infertility. We present a case of a 30-year-old man who presented to the Emergency Department of our tertiary care hospital with spontaneous intra-abdominal rupture of the seminoma in undescended testis with hemoperitoneum. This is a rare presentation of seminoma and emphasises the importance of scrotal examination in young men presenting with acute abdomen. Read More

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April 2018
4 Reads

PD-1/PD-L1 expression in a series of intracranial germinoma and its association with Foxp3+ and CD8+ infiltrating lymphocytes.

PLoS One 2018 4;13(4):e0194594. Epub 2018 Apr 4.

Department of Neurosurgery, Kyoto University Graduate School of Medicine, Kyoto, Japan.

One histopathological characteristic of intracranial germinoma is abundant tumor-infiltrating lymphocytes (TILs) showing a two-cell pattern with large undifferentiated tumor cells. The programmed cell death 1 (PD-1)/programmed cell death 1 ligand (PD-L) axis has recently been recognized as an anti-tumor immune system. To evaluate intratumor immune status in intracranial germinoma, we examined expressions of PD-1 and PD-L1 (clone 28-8) and subtypes of TILs. Read More

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July 2018
12 Reads

Anti-Muellerian hormone concentration in bitches with histopathologically diagnosed ovarian tumours and cysts.

Reprod Domest Anim 2018 Jun 30;53(3):784-792. Epub 2018 Mar 30.

Laboklin GmbH & Co.KG, Bad Kissingen, Germany.

Increased concentrations of Anti-Muellerian hormone (AMH) can indicate a granulosa cell tumour as shown in women, mares and cows. To investigate AMH to differentiate canine granulosa cell tumour from other ovarian pathologies, we evaluated the ovaries of 63 bitches. Blood serum samples were collected before surgery for AMH analysis. Read More

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June 2018
3 Reads

Large intra-abdominal seminoma in a left undescended testicle complicated by torsion.

BMJ Case Rep 2018 Mar 28;2018. Epub 2018 Mar 28.

Department of Urology, University of Texas Health Science Center, San Antonio, Texas, USA.

A 39-year-old man presented with a 2-day history of worsening constant, dull diffuse lower abdominal pain with associated constipation and known history of left undescended testicle. He was evaluated at an outside hospital where a non-contrasted CT scan revealed a 20 cm well-circumscribed soft tissue mass within the pelvis.He was referred and further imaging revealed a 12 cm heterogeneous mass with foci of air that appeared to be contiguous with the left spermatic cord. Read More

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March 2018
4 Reads

A Risk-Adapted Approach to Patients with Stage I Seminoma according to the Status of Rete Testis: The Fourth Spanish Germ Cell Cancer Group Study.

Oncology 2018 26;95(1):8-12. Epub 2018 Mar 26.

Medical Oncology Department, Institut Catalá d'Oncologia, IDIBELL, L'Hospitalet de Llobregat, L'Hospitalet de Llobregat, Spain.

Objective: The aim of this study was to assess a risk-adapted strategy for stage I seminoma guided by the presence of rete testis invasion.

Methods: Between January 2013 and December 2015, a total of 135 consecutive patients with stage I seminoma from 18 Spanish tertiary hospitals were included in a prospective multicenter study. Median patient age was 38 years (range 22-60). Read More

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July 2018
13 Reads

Indications for salvage surgery during treatment for intracranial germ cell tumors.

J Neurooncol 2018 Jul 26;138(3):601-607. Epub 2018 Mar 26.

Department of Neurosurgery, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi, 980-8574, Japan.

This study retrospectively reviewed our single institute experience to clarify the optimal indication and timing of salvage surgery. Retrospective analysis of 159 consecutive cases with germ cell tumors identified 20 cases with salvage surgery. These cases were classified based on the radiological response to neoadjuvant treatment before salvage surgery into increase (growing group, five cases), no change (stable group, seven cases), and decrease (shrinkage group, eight cases) in tumor size. Read More

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July 2018
1 Read

Neuroendoscopic Cylinder Surgery and 5-Aminolevulinic Acid Photodynamic Diagnosis of Deep-Seated Intracranial Lesions.

World Neurosurg 2018 Aug 23;116:e35-e41. Epub 2018 Mar 23.

Department of Neurosurgery, Nagoya University Graduate School of Medicine, Nagoya, Japan.

Background: Microscopic detection of intracranial brain tumors with 5-aminolevulinic acid (5-ALA) has proven extremely useful, and reports the use of 5-ALA have recently increased. However, few reports have described 5-ALA photodynamic diagnosis (PDD) using a neuroendoscope. We performed neuroendoscopic 5-ALA PDD for various brain lesions and present a procedure using only a neuroendoscope. Read More

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Granulomatous Response in Intracranial Germinomas: Diagnostic Problems.

Int J Appl Basic Med Res 2018 Jan-Mar;8(1):51-53

Department of Pathology, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India.

Intracranial germinomas are rare and account for <0.5% of primary intracranial tumors. In contrast to the gonadal germinomas, these do not show granulomatous response within the tumor. Read More

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March 2018
4 Reads

Active Surveillance for Stage I Testicular Cancer: A Four-decade-old Experiment Proven Correct.

Eur Urol 2018 06 16;73(6):908-909. Epub 2018 Mar 16.

Division of Urology, Department of Surgical Oncology, Princess Margaret Cancer Centre, Toronto, Canada. Electronic address:

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