1,079 results match your criteria Germinoma Central Nervous System

Multi-institutional analysis of treatment modalities in basal ganglia and thalamic germinoma.

Pediatr Blood Cancer 2021 Jun 14:e29172. Epub 2021 Jun 14.

Division of Hematology, Oncology and Bone Marrow Transplant, Nationwide Children's Hospital and The Ohio State University, Columbus, Ohio, USA.

Background: Central nervous system (CNS) germinomas are treatment-sensitive tumors with excellent survival outcomes. Current treatment strategies combine chemotherapy with radiotherapy (RT) in order to reduce the field and dose of RT. Germinomas originating in the basal ganglia/thalamus (BGTGs) have proven challenging to treat given their rarity and poorly defined imaging characteristics. Read More

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Co-existence of multiple sclerosis and germinoma in an adult male: Case report.

Surg Neurol Int 2021 19;12:177. Epub 2021 Apr 19.

Department of Neurosurgery, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, United States.

Background: Concurrent diagnosis of multiple sclerosis (MS) and the central nervous system (CNS) germinoma is rare. The diagnostic criteria for MS rely primarily on clinical presentation, and CNS germinoma can present as an MS mimic. These factors contribute to the rarity of dual diagnosis. Read More

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Neoadjuvant Chemotherapy and Whole Ventricular Irradiation for Pure Intracranial Germinoma: A Comparison of Three Brain-Sparing Techniques.

Cureus 2021 Mar 3;13(3):e13670. Epub 2021 Mar 3.

Department of Radiation Oncology, Keck School of Medicine of the University of Southern California, Los Angeles, USA.

Objective To quantitate and compare the dosimetric properties of three brain-sparing radiation therapy techniques for pure intracranial germinomas with dose-volume analysis of target and normal brain structures. Methods We identified 18 patients with central nervous system (CNS) germinoma who had achieved local control and had excellent neurocognitive outcomes. Four patients who were treated with a simultaneous integrated boost (SIB) plan of 22. Read More

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Stalking the Diagnosis.

N Engl J Med 2021 Apr;384(13):1262-1267

From the Departments of Medicine (D.J.M., H.H.) and Neurology (M.R.) and the Division of Infectious Diseases (H.H.), University of California, San Francisco, San Francisco; and the Department of Neurology and the Division of Hematology and Oncology, Feinberg School of Medicine, Northwestern University, Chicago (P.K.).

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[Germinoma in a patient with emaciation and growth retardation. Case report].

Arch Argent Pediatr 2021 04;119(2):e171-e175

Médica de planta de Clínica Pediátrica, Sector de Internación (CEM 4), Hospital General de Niños Pedro de Elizalde, Ciudad Autónoma de Buenos Aires, Argentina.

Central nervous system tumors are the second most frequent oncological disease among children and teenagers. Among the intracranial tumors, the germ cells ones are infrequent. The symptoms they cause are headaches, nausea and vomiting, hormonal deficits, visual disturbances, weight loss, poor growth and early puberty. Read More

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An Unusual Case of Primary Intracranial Germinoma with Diffuse Subarachnoid Spread Masquerading as Tuberculous Meningitis.

Asian J Neurosurg 2020 Oct-Dec;15(4):1027-1030. Epub 2020 Oct 19.

Department of Pathology, Govind Ballabh Pant Institute of Postgraduate Medical Education and Research, New Delhi, India.

Central nervous system (CNS) germinomas often extend or disseminate into the ventricular and subarachnoid space. We present a case of primary CNS germinoma consisting mainly of meningeal dissemination, which is extremely unusual and must be kept in the differential diagnosis. Read More

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October 2020

Clinical outcomes of pediatric patients with autism spectrum disorder and other neurodevelopmental disorders and intracranial germ cell tumors.

Pediatr Blood Cancer 2021 Mar 10:e28935. Epub 2021 Mar 10.

Department of Radiation Oncology, Massachusetts General Hospital, Boston, Massachusetts, USA.

Introduction: Intracranial germ cell tumors (IGCTs) are rare tumors of the central nervous system with peak incidence around puberty. Given the developmental origins of IGCTs, we investigated the prevalence of neurodevelopmental disorders (NDDs) in patients with IGCTs and characterized outcomes for patients with NDD and IGCTs.

Methods: A retrospective review of medical records was conducted for 111 patients diagnosed with IGCTs between 1998 and 2018 and evaluated at the Massachusetts General Hospital. Read More

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Relapse pattern and quality of life in patients with localized basal ganglia germinoma receiving focal radiotherapy, whole-brain radiotherapy, or craniospinal irradiation.

Radiother Oncol 2021 05 19;158:90-96. Epub 2021 Feb 19.

Department of Radiation Oncology, Beijing Tiantan Hospital, Capital Medical University, China; Beijing Neurosurgery Institute, Capital Medical University, China.

Background And Purpose: The optimal target volume in localized basal ganglia (BG) germinoma is still undetermined. Thus, based on the relapse pattern and health-related quality of life (HRQOL), we evaluated three target volumes.

Material And Methods: The clinical data of 161 patients with localized BG germinoma were included in this retrospective study. Read More

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[Treatment outcomes in patients with central nervous system germinoma (neuro-ophthalmic aspects)].

Zh Vopr Neirokhir Im N N Burdenko 2021 ;85(1):78-86

Burdenko Neurosurgery Center, Moscow, Russia.

Objective: The analyze the neuro-ophthalmic outcomes in patients with pineal and suprasellar germinoma after complex treatment.

Material And Methods: There were 125 patients (88 males, 37 females) with primary CNS germinoma for the period 2008-2017. All patients were divided into 3 groups depending on the tumor localization: pineal area - 62 patients, suprasellar neoplasm - 38 patients, bifocal germinoma - 25 patients. Read More

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February 2021

Multimodality treatment for Central Nervous System Germ Cell Tumors: Disease spectrum and management strategies - A tertiary care center experience from India.

Clin Neurol Neurosurg 2021 Mar 13;202:106481. Epub 2021 Jan 13.

Department of Radiotherapy & Oncology, PGIMER, Chandigarh, India. Electronic address:

Objective: Intracranial germ cell tumors (GCTs) are relatively rare neoplasms, representing 2-3 % of paediatric brain tumors in Western countries and 8-15 % in East Asia. Here, we discuss the clinical features and treatment outcomes in patients with central nervous system (CNS) GCTs treated at our institute.

Methods: Medical records of all primary CNS GCT patients were retrieved retrospectively from 2007 to 2019. Read More

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Characterization of high-grade pineal region lesions: the usefulness of apparent diffusion coefficient volumetric values.

Acta Radiol 2021 Jan 26:284185120986912. Epub 2021 Jan 26.

Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Roma-UOC Radiologia e Neuroradiologia, Polo Diagnostica per immagini, radioterapia, oncologia ed ematologia, Area diagnostica per immagini, Rome, Italy.

Background: High-grade pineal region tumors are rare and heterogeneous types of primary central nervous system neoplasms; radiological differential diagnosis is challenging but it is important because it has a therapeutic relevance.

Purpose: To discriminate among high-grade pineal region tumors by combining apparent diffusion coefficient (ADC) volumetric values and qualitative features in order to predict their histology.

Material And Methods: Twenty-two patients with high-grade pineal region tumors were assessed by qualitative and quantitative analysis. Read More

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January 2021

Mission impossible: chemotherapy in the intensive care for pineal region germ cell tumor.

Childs Nerv Syst 2021 Jan 20. Epub 2021 Jan 20.

Department of Neurosurgery, All India Institute of Medical Sciences, New Delhi, India.

Pineal region tumors are rare and a heterogenous group of primary central nervous system tumors which are primarily classified as germ cell tumors and non-germ cell tumors. Chemotherapy and radiotherapy as the primary treatment modalities have been reported to result in good outcomes. We discuss the case of a young girl who presented to our emergency department in an unconscious state and had a large lesion in the posterior third ventricular region, but without any associated hydrocephalus which could explain her stuporous state. Read More

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January 2021

Detecting non-germinomatous germ cell tumor component by arterial spin labeling perfusion-weighted MR imaging in central nervous system germ cell tumor.

Eur J Radiol 2021 Mar 7;136:109523. Epub 2021 Jan 7.

Department of Neurosurgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8551, Japan. Electronic address:

Purpose: Differentiating between germinoma and non-germinomatous germ cell tumor (NGGCT) is important because sensitivity to chemotherapy and/or radiotherapy is quite different between these two subgroups. In this study, we evaluated whether the arterial spin labeling (ASL) based perfusion-weighted imaging (PWI) could provide additional information for the differential diagnosis between germinoma and NGGCT.

Method: Between 2011 and 2018, 20 patients with central nervous system (CNS) germ cell tumor (GCT) who underwent preoperative MR imaging including ASL-PWI were enrolled in this study. Read More

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Ovarian tissue cryopreservation and transplantation in patients with central nervous system tumours.

Hum Reprod 2021 04;36(5):1296-1309

Pôle de Gynécologie, Institut de Recherche Expérimentale et Clinique (IREC), Université Catholique de Louvain, Brussels, Belgium.

Study Question: Is there a possibility of reseeding cancer cells potentially present in frozen ovarian tissue from patients with central nervous system (CNS) tumours?

Summary Answer: Malignancy reseeding in cryopreserved ovarian tissue from 20 patients with CNS tumours was not detected by histology, immunohistochemistry (IHC), molecular biology or xenotransplantation.

What Is Known Already: Ovarian metastasis potential has been documented in patients with leukaemia, borderline ovarian tumours, advanced breast cancer and Ewing sarcoma. However, data on the safety of transplanting frozen-thawed ovarian tissue from cancer patients with CNS tumours are still lacking. Read More

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Primary intracranial germ cell tumors in children 36-year experience of a single center.

J Cancer Res Ther 2020 Oct-Dec;16(6):1459-1465

Department of Pediatric Oncology, Faculty of Medicine, Hacettepe University, Ankara, Turkey.

Purpose: Intracranial germ cell tumors (ICGCTs) comprise approximately 0.4%-3% of all brain tumors. In this study, we aim to evaluate clinical characteristics, treatment and outcomes of patients with ICGCT. Read More

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December 2020

Treatment of Primary Central Nervous System Germinomas With Short-course Induction Chemotherapy Followed by Low-dose Radiotherapy Without a Tumor Bed Boost: Prognostic Impact of Human Chorionic Gonadotropin.

J Pediatr Hematol Oncol 2020 Nov 23. Epub 2020 Nov 23.

Department of Radiation Oncology, Proton and Radiation Therapy Center, Linkou Chang Gung Memorial Hospital.

Objective: To investigate the clinical utility of short-course induction chemotherapy followed by low-dose radiotherapy without a tumor bed boost in patients with primary central nervous system (CNS) germinomas.

Methods: We retrospectively reviewed the clinical records of patients with primary CNS germinomas who received short-course induction chemotherapy (2 cycles of cisplatin 20 mg/m plus etoposide 40 or 100 mg/m for 5 days) followed by low-dose radiotherapy (dose: 2340 cGy) without a tumor bed boost. Disease-free survival and overall survival served as the main outcome measures. Read More

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November 2020

Treatment outcome and long-term follow-up of central nervous system germ cell tumor using upfront chemotherapy with subsequent photon or proton radiation therapy: a single tertiary center experience of 127 patients.

BMC Cancer 2020 Oct 9;20(1):979. Epub 2020 Oct 9.

Departments of Pediatrics, Seoul National University College of Medicine, Seoul, Republic of Korea.

Background: Central nervous system germ cell tumors (CNS GCTs) are a heterogeneous group of brain tumors, which are more common in Asian countries. There have been different therapeutic strategies in treating germinoma and non-germinomatous germ cell tumors (NGGCT), depending on prognosis. Moreover, long-term follow up should be emphasized due to higher late complication rates. Read More

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October 2020

Klinefelter syndrome and germ cell tumors: review of the literature.

Int J Pediatr Endocrinol 2020 30;2020:18. Epub 2020 Sep 30.

Department of Pediatrics, ZNA Queen Paola Children's Hospital, Lindendreef 1, 2020 Antwerp, Belgium.

Objective: The most common presentation of Klinefelter syndrome (KS) is infertility and features of hypogonadism. Currently no consensus exists on the risk of malignancy in this syndrome. Several case reports show an incidence of extragonadal germ cells tumors (eGCT) of 1. Read More

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September 2020

Single-institution case series of pituitary biopsy for suspected germinoma in the pediatric population: diagnostic utility, operative risks, and biopsy approaches.

Sci Rep 2020 09 17;10(1):15257. Epub 2020 Sep 17.

Department of Neurosurgery, Boston Children's Hospital, 300 Longwood Avenue, Boston, MA, 02115, USA.

Little has been reported on the safety and efficacy of pituitary biopsy in the pediatric population for suspected germinoma. An updated review is needed. Patients who underwent biopsy (endoscopic endonasal vs. Read More

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September 2020

Central diabetes insipidus caused by a pituitary stalk germinoma resembling infundibuloneurohypophysitis.

BMJ Case Rep 2020 Sep 9;13(9). Epub 2020 Sep 9.

Endocrinology, Instituto Portugues de Oncologia de Lisboa Francisco Gentil EPE, Lisbon, Portugal.

We report the case of a pituitary stalk germinoma initially misdiagnosed and treated as infundibuloneurohypophysitis (INH). A 27-year-old man presented with a 1-year history of polydipsia, polyuria, nycturia consistent with central diabetes insipidus and a hyperintense pituitary stalk lesion on MRI. A possible INH diagnosis was considered, after excluding other pathologies. Read More

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September 2020

Endoscopic Ipsilateral Interhemispheric Approach for Resection of Selected Deep Medial Brain Tumors.

World Neurosurg 2020 12 27;144:162-169. Epub 2020 Aug 27.

Department of Neurosurgery, John Radcliffe Hospital, Oxford University Hospitals NHS Foundation Trust, Oxford, UK; Nuffield Department of Clinical Neurosciences, University of Oxford, John Radcliffe Hospital, Oxford, UK; Nuffield Department of Surgery, University of Oxford, John Radcliffe Hospital, Oxford, UK. Electronic address:

Background: The interhemispheric fissure provides a natural surgical corridor to access tumors of the deep medial surface of the brain. Conventional microscopic approaches to these tumors are limited by the narrow width of the interhemispheric fissure and need for retraction of brain tissue or traversing overlying cortex. Over the last decade, the endoscope has been used to improve visualization of the operative field in neurosurgery, with benefits in terms of surgical ergonomics and extent of tumor resections. Read More

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December 2020

The clinical and imaging features of infratentorial germinomas compared with supratentorial ectopic germinomas.

Acta Radiol 2020 Aug 27:284185120952780. Epub 2020 Aug 27.

Department of Radiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, PR China.

Background: Intracranial germinoma is very sensitive to chemoradiotherapy, while the risk of infratentorial operation is high. The accurate diagnosis can provide the more reasonable treatment, avoiding the unnecessary therapeutic risks.

Purpose: To evaluate the clinical and imaging features of infratentorial germinomas. Read More

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So-called bifocal tumors with diabetes insipidus and negative tumor markers: are they all germinoma?

Neuro Oncol 2021 02;23(2):295-303

Department of Neurosurgery, Nagoya University School of Medicine, Nagoya, Japan.

Background: The Delphi consensus statements on the management of germ cell tumors (GCTs) failed to reach agreements on the statement that the cases with (i) pineal and neurohypophyseal bifocal lesion, (ii) with diabetes insipidus, and (iii) with negative tumor markers can be diagnosed as germinoma without histological verification. To answer this, multicenter retrospective analysis was performed.

Methods: A questionnaire on clinical findings, histological diagnosis, and details of surgical procedures was sent to 86 neurosurgical and 35 pediatrics departments in Japan. Read More

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February 2021

[Neuro-ophthalmological symptoms in patients with pineal and suprasellar germinoma].

Vestn Oftalmol 2020 ;136(4):39-46

N.N. Burdenko National Medical Research Center of Neurosurgery, Moscow, Russia.

Purpose: To analyze neuro-ophthalmology symptoms in patients with germinomas located in pineal and suprasellar regions.

Material And Methods: The study analyzed 133 patients with germinoma who were receiving treatment in Burdenko Neuro-surgical Institute from 2008 to 2017. Assessment of results was performed by neuro-ophthalmology examination, a computerized oculograph was used for the objectification of the severity of ocular-motor and pupillary disorders. Read More

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Sellar Pathologies Mimicking Pituitary Tumors.

Neurol India 2020 May-Jun;68(Supplement):S154-S160

Department of Neurosurgery, Bombay Hospital Institute of Medical Sciences, Mumbai, Maharashtra, India.

The most common sellar pathology that merits neurosurgical attention is the pituitary adenoma. However, some developmental, inflammatory, and neoplastic lesions may primarily or secondarily involve the sella, mimicking pituitary tumors. Advances in imaging and endocrinological assessment have helped in the recognition of these less common sellar, supra sellar pathologies, which may occasionally create confusion in management. Read More

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Central diabetes insipidus and pituitary stalk thickening in adults: distinction of neoplastic from non-neoplastic lesions.

Eur J Endocrinol 2020 Jul;181(3):95-105

Department of Endocrinology and Nutrition, Université Catholique de Louvain, Cliniques Universitaires Saint-Luc, Brussels, Belgium.

Context: Association of central diabetes insipidus (CDI) and pituitary stalk thickening (PST) may have several etiologies (including malignancies) and differential diagnosis remains often difficult.

Objective: The purpose of this study was to identify which clinical, biochemical or radiological features could help clinicians to make an etiological diagnosis, especially distinguishing neoplastic from non-neoplastic pituitary stalk lesions.

Designs And Methods: We retrospectively analyzed clinical, biochemical, radiological and histological data of 38 adult patients diagnosed with CDI and PST of proven etiology. Read More

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Teaching Video NeuroImages: Convergence retraction nystagmus due to compressive lesion of the dorsal midbrain.

Neurology 2020 05 4;94(21):e2285-e2286. Epub 2020 May 4.

From the Department of Ophthalmology and Vision Sciences, University of Toronto, Canada.

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