1,045 results match your criteria Germinoma Central Nervous System


Central diabetes insipidus and pituitary stalk thickening in adults: distinction of neoplastic from non-neoplastic lesions.

Eur J Endocrinol 2020 Jul;181(3):95-105

Department of Endocrinology and Nutrition, Université Catholique de Louvain, Cliniques Universitaires Saint-Luc, Brussels, Belgium.

Context: Association of central diabetes insipidus (CDI) and pituitary stalk thickening (PST) may have several etiologies (including malignancies) and differential diagnosis remains often difficult.

Objective: The purpose of this study was to identify which clinical, biochemical or radiological features could help clinicians to make an etiological diagnosis, especially distinguishing neoplastic from non-neoplastic pituitary stalk lesions.

Designs And Methods: We retrospectively analyzed clinical, biochemical, radiological and histological data of 38 adult patients diagnosed with CDI and PST of proven etiology. Read More

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http://dx.doi.org/10.1530/EJE-20-0058DOI Listing

Pediatric Central Nervous System Germinoma: What Can We Understand From a Worldwide Effort to Maximize Cure and Minimize Risk?

Int J Radiat Oncol Biol Phys 2020 Jun 7;107(2):227-231. Epub 2020 Apr 7.

Department of Radiation Oncology and Neurosurgery, University of Cincinnati College of Medicine, Cincinnati, Ohio.

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http://dx.doi.org/10.1016/j.ijrobp.2020.03.039DOI Listing

A Rare Case of a Pediatric Medullary Intracranial Germinoma.

World Neurosurg 2020 06 5;138:137-140. Epub 2020 Mar 5.

Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, Connecticut, USA. Electronic address:

Background: Germinomas are rare intracranial lesions, with medulla germinomas being reported in only approximately 20 cases to date. These tumors are extremely sensitive to radiotherapy, and knowledge of them can allow for accurate diagnosis as well as significantly impact treatment and prognosis.

Case Description: We present a case of medullary germinoma and review the cases previously reported in the literature. Read More

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http://dx.doi.org/10.1016/j.wneu.2020.02.147DOI Listing

Comparison on epidemiology, tumor location, histology, and prognosis of intracranial germ cell tumors between Mayo Clinic and Japanese consortium cohorts.

J Neurosurg 2020 Jan 31:1-11. Epub 2020 Jan 31.

Departments of1Neurologic Surgery and.

Objective: Central nervous system (CNS) germ cell tumors (GCTs) are rare malignant neoplasms that arise predominantly in adolescents and young adults. CNS GCTs demonstrate characteristic trends in national associations, with implications for both tumor incidence and genetics. Although the incidence of CNS GCTs is markedly higher in East Asia than Western countries, direct comparative analyses between these CNS GCT populations are limited. Read More

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http://dx.doi.org/10.3171/2019.11.JNS191576DOI Listing
January 2020

Endoscopic Transsphenoidal Approach in Treatment of Germinomas of the Chiasmosellar Region.

Asian J Neurosurg 2019 Oct-Dec;14(4):1190-1195. Epub 2019 Nov 25.

Department of Neurooncology, N. N. Burdenko National Scientific and Practical Center for Neurosurgery, Moscow, Russia.

Introduction: Germinogenic central nervous system (CNS) tumors represent a heterogeneous group of tumors, constituting approximately 0.4% of all primary brain tumors. Removal of the tumor has no prognostic value. Read More

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http://dx.doi.org/10.4103/ajns.AJNS_156_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6896623PMC
November 2019

Intensity-modulated ventricular irradiation for intracranial germ-cell tumors: Survival analysis and impact of salvage re-irradiation.

PLoS One 2019 20;14(12):e0226350. Epub 2019 Dec 20.

Department of Hematology and Clinical Oncology, Hospital Israelita Albert Einstein, São Paulo, Brazil.

Background And Purpose: The roles of surgery, chemotherapy, and parameters of radiation therapy for treating very rare central nervous system germ cell tumors (CNS-GCT) are still under discussion. We aimed to evaluate the survival and recurrence patterns of patients with CNS-GCT treated with chemotherapy followed by whole ventricle irradiation with intensity-modulated radiation therapy.

Materials And Methods: We reviewed the clinical outcomes of 20 consecutive patients with CNS-GCT treated with chemotherapy and intensity-modulated radiation therapy from 2004 to 2014 in two partner institutions. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0226350PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6924640PMC

Isolated Langerhans cell histiocytosis in the hypothalamic-pituitary region: a case report.

BMC Endocr Disord 2019 Dec 19;19(1):143. Epub 2019 Dec 19.

Department of Endocrinology, the First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, 310003, Zhejiang, China.

Background: Langerhans cell histiocytosis (LCH) is a rare disease that mainly affects children, but this disease is significantly rarer in patients who are older than 15 years. In this disease, any organ can be involved. The skeleton, skin and lung are commonly affected, and isolated hypothalamic-pituitary (HP) involvement is relatively rare. Read More

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http://dx.doi.org/10.1186/s12902-019-0474-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6924050PMC
December 2019

In Reply to Byun et al.

Int J Radiat Oncol Biol Phys 2020 01;106(1):219-220

Radiation Medicine Program, Princess Margaret Cancer Centre, University Health Network, Toronto, Canada; Division of Haematology/Oncology, Hospital for Sick Children, Toronto, Canada.

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http://dx.doi.org/10.1016/j.ijrobp.2019.09.046DOI Listing
January 2020

In Regard to Yan et al.

Int J Radiat Oncol Biol Phys 2020 01;106(1):218-219

Department of Radiation Oncology, Yonsei Cancer Center, Yonsei University College of Medicine, Seoul, Republic of Korea; Department of Radiation Oncology, CHA Bundang Medical Center, CHA University, Seongnam, Republic of Korea.

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http://dx.doi.org/10.1016/j.ijrobp.2019.09.045DOI Listing
January 2020

Intracranial Germ Cell Tumors in Adolescents and Young Adults: A 40-Year Multi-Institutional Review of Outcomes.

Int J Radiat Oncol Biol Phys 2020 02 22;106(2):269-278. Epub 2019 Oct 22.

Princess Margaret Cancer Centre, Toronto, Ontario; University of Toronto, Toronto, Ontario; The Hospital for Sick Children, Toronto, Ontario.

Purpose: The aim of this study was to determine the practice patterns and outcomes of intracranial germ cell tumors (IGCT) in adolescents and young adults according to different therapeutic approaches.

Methods And Materials: One-hundred twelve patients with IGCT aged 15 to 39 years were managed at either XX or the XY center from 1975 to 2015. The charts were retrospectively reviewed and data collected. Read More

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http://dx.doi.org/10.1016/j.ijrobp.2019.10.020DOI Listing
February 2020
1 Read
4.258 Impact Factor

Symptom interval and treatment burden for patients with malignant central nervous system germ cell tumours.

Arch Dis Child 2020 Mar 8;105(3):247-252. Epub 2019 Oct 8.

Paediatric Oncology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.

Objective: Patients with central nervous system germ cell tumours (CNS-GCTs) commonly initially present to primary care or general paediatricians. Prolonged symptom intervals (SI) are frequently seen in CNS-GCTs and have been associated with inferior outcomes in other brain tumours. This study reviewed the clinical presentation of CNS-GCTs and examined the effect of prolonged SI. Read More

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http://dx.doi.org/10.1136/archdischild-2019-317245DOI Listing
March 2020
2 Reads

Clinical and neuropsychological outcome of pediatric non-midline central nervous system germinoma treated with chemotherapy and reduced dose/volume irradiation: The Children's Hospital Los Angeles experience.

Pediatr Blood Cancer 2019 12 10;66(12):e27983. Epub 2019 Sep 10.

Children's Center for Cancer and Blood Diseases, Division of Hematology, Oncology and Blood and Marrow Transplantation, Children's Hospital Los Angeles, Los Angeles, California.

Background: Germ cell tumors (GCT) arising from non-midline structures (basal ganglia, thalamus, and posterior fossa) are rare. Although patients with midline (pineal and suprasellar) germinoma have excellent survival with chemotherapy and whole ventricular irradiation (WVI), germinoma in non-midline locations have traditionally been treated with craniospinal irradiation (CSI) or whole brain irradiation (WBI) to achieve similar outcomes. However, CSI and WBI are associated with significant long-term neuropsychological sequelae. Read More

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http://dx.doi.org/10.1002/pbc.27983DOI Listing
December 2019
2 Reads
2.562 Impact Factor

Integrated clinical, histopathological, and molecular data analysis of 190 central nervous system germ cell tumors from the iGCT Consortium.

Neuro Oncol 2019 12;21(12):1565-1577

Division of Brain Tumor Translational Research, National Cancer Center Research Institute, Tokyo, Japan.

Background: We integrated clinical, histopathological, and molecular data of central nervous system germ cell tumors to provide insights into their management.

Methods: Data from the Intracranial Germ Cell Tumor Genome Analysis (iGCT) Consortium were reviewed. A total of 190 cases were classified as primary germ cell tumors (GCTs) based on central pathological reviews. Read More

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http://dx.doi.org/10.1093/neuonc/noz139DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6917411PMC
December 2019
4 Reads

A Central Role of Radiation Therapy in Central Nervous System Germinoma.

Int J Radiat Oncol Biol Phys 2019 08;104(5):970-971

Department of Radiation Oncology, Dana-Farber Cancer Institute, Brigham and Women's Hospital, Boston, Massachusetts.

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http://dx.doi.org/10.1016/j.ijrobp.2019.05.020DOI Listing
August 2019
6 Reads

Spare the Rad, Spoil the Child (or Young Adult).

Authors:
Nadia N I Laack

Int J Radiat Oncol Biol Phys 2019 08;104(5):969

Mayo Clinic, Rochester, Minnesota.

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http://dx.doi.org/10.1016/j.ijrobp.2018.04.021DOI Listing

No Further Therapy.

Int J Radiat Oncol Biol Phys 2019 08;104(5):969-970

Division of Hematology/Oncology, Department of Pediatrics, Seattle Children's Hospital, Fred Hutchinson Cancer Research Center, Seattle, Washington.

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http://dx.doi.org/10.1016/j.ijrobp.2018.05.030DOI Listing
August 2019
4 Reads

Germination of Germinoma Treatment.

Int J Radiat Oncol Biol Phys 2019 08;104(5):967-968

Department of Radiation Medicine, Oregon Health & Science University, Portland, Oregon.

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http://dx.doi.org/10.1016/j.ijrobp.2018.03.040DOI Listing

Upfront chemotherapy followed by response adaptive radiotherapy for intracranial germinoma: Prospective multicenter cohort study.

Radiother Oncol 2019 09 15;138:180-186. Epub 2019 Jul 15.

Department of Neurosurgery, Yonsei University College of Medicine, Seoul, Republic of Korea. Electronic address:

Purpose: To assess the efficacy of upfront chemotherapy followed by response-adapted reduced-dose/reduced-volume radiotherapy (RT) for intracranial germinoma.

Materials And Methods: Ninety-one patients from five institutions were registered in the KSPNO G051/G081 Protocol. Germinomas were classified as solitary or multiple/disseminated diseases, and upfront chemotherapy was administered. Read More

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http://dx.doi.org/10.1016/j.radonc.2019.06.002DOI Listing
September 2019
6 Reads

Kelch-like Protein 11 Antibodies in Seminoma-Associated Paraneoplastic Encephalitis.

N Engl J Med 2019 07;381(1):47-54

From the Department of Biochemistry and Biophysics (C.M.-B., B.D.O., S.E.V., H.A.S., K.C.Z., L.M.K., J.L.D.), the Weill Institute for Neurosciences (B.T., I.O.B., S.J. Pleasure, M.R.W.), the Department of Neurology (B.T., I.O.B., S.J. Pleasure, M.R.W.), and the Chan Zuckerberg Biohub (J.L.D.), University of California, San Francisco, San Francisco; and the Departments of Laboratory Medicine and Pathology (D.D., T.J.K., A.M., V.A.L., S.J. Pittock), Neurology (D.D., A.M., V.A.L., S.J. Pittock), and Immunology (V.A.L.), Mayo Clinic, Rochester, MN.

A 37-year-old man with a history of seminoma presented with vertigo, ataxia, and diplopia. An autoantibody specific for kelch-like protein 11 (KLHL11) was identified with the use of programmable phage display. Immunoassays were used to identify KLHL11 IgG in 12 other men with similar neurologic features and testicular disease. Read More

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http://dx.doi.org/10.1056/NEJMoa1816721DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6800027PMC
July 2019
12 Reads
55.873 Impact Factor

Germinoma Mimicking Brain Inflammation: A Case Report.

Child Neurol Open 2019 20;6:2329048X19848181. Epub 2019 May 20.

Department of Neurology and Epileptology, Children's Memorial Health Institute, Warsaw, Poland.

The authors report a case of a germinoma of the brain in the child with symptoms restricted to central nervous system. Ten-year-old girl presented initially with sight deterioration, learning difficulties, abnormal behavior, polydipsia, and polyuria. Brain magnetic resonance examination revealed T2 hyperintensity of the corpus callosum, anterior commissure, and caudate nuclei. Read More

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http://dx.doi.org/10.1177/2329048X19848181DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6591517PMC
May 2019
6 Reads

Comprehensive Evaluation of Rare Pituitary Lesions: A Single Tertiary Care Pituitary Center Experience and Review of the Literature.

Endocr Pathol 2019 Sep;30(3):219-236

Department of Neurosurgery, Lausanne University Hospital, Rue du Bugnon 44, 1005, Lausanne, Switzerland.

The 2017 World Health Organization classification of central nervous system and endocrine tumors have introduced significant changes in the diagnostic criteria for pituitary lesions. The aim of our paper is to describe the epidemiological, clinico-pathological, and radiological features of a single consecutive institutional surgical series of rare pituitary lesions, using these new criteria. Of the 316 endoscopic endonasal trans-sphenoidal approaches performed for pituitary lesions between 2010 and 2018, 15 rare lesions were encountered. Read More

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http://dx.doi.org/10.1007/s12022-019-09581-6DOI Listing
September 2019
6 Reads
1.644 Impact Factor

Intratumoural immune cell landscape in germinoma reveals multipotent lineages and exhibits prognostic significance.

Neuropathol Appl Neurobiol 2020 02 29;46(2):111-124. Epub 2019 Jul 29.

Division of Brain Tumor Translational Research, National Cancer Center Research Institute, Tokyo, Japan.

Aims: Alterations in microenvironments are a hallmark of cancer, and these alterations in germinomas are of particular significance. Germinoma, the most common subtype of central nervous system germ cell tumours, often exhibits massive immune cell infiltration intermingled with tumour cells. The role of these immune cells in germinoma, however, remains unknown. Read More

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http://dx.doi.org/10.1111/nan.12570DOI Listing
February 2020
5 Reads
3.927 Impact Factor

Basal Ganglionic Germinoma With Syncytiotrophoblastic Giant Cells Mimicking a Growing Hematoma.

J Craniofac Surg 2019 Jun;30(4):e306-e308

Department of Neurosurgery, Central Hospital of Zibo, Zibo City, Shandong Province, China.

Basal ganglionic germinoma (BGG) with syncytiotrophoblastic giant cells (STGC) is a rare type of ectopic germ cell tumors with mild elevation of human chorionic gonadotropin level. Intratumoral hemorrhage is not uncommon for BGG, but presenting with repeated hemorrhage is very rare. Herein, we described an extremely rare case of BGG with STGC mimicking a growing hematoma. Read More

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http://dx.doi.org/10.1097/SCS.0000000000005226DOI Listing
June 2019
3 Reads

The Purely Endoscopic Supracerebellar Infratentorial Approach for Resecting Pineal Region Tumors with Preservation of Cerebellomesencephalic Vein: Technical Note and Preliminary Clinical Outcomes.

World Neurosurg 2019 Aug 25;128:e334-e339. Epub 2019 Apr 25.

Department of Neurosurgery, Zhongshan Hospital Affiliated to Fudan University, Shanghai, China; Shanghai Key Laboratory of Medical Image Computing and Computer Assisted Intervention, Shanghai Medical College, Fudan University, Shanghai, China. Electronic address:

Background: The cerebellomesencephalic vein (CMV) was frequently sacrificed in surgery approached via the supracerebellar infratentorial (SCIT) route for resecting pineal region tumors, which resulted in potential risk of neurologic deficit. Preserving the CMV in the SCIT approach could enhance the safety and effectiveness of this natural corridor surgery. The aim of this article was to identify the probability and safety of preserving the CMV through the application of neuroendoscopy in the SCIT approach. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.04.146DOI Listing
August 2019
8 Reads

Descriptive epidemiology of germ cell tumors of the central nervous system diagnosed in the United States from 2006 to 2015.

J Neurooncol 2019 Jun 25;143(2):251-260. Epub 2019 Apr 25.

Central Brain Tumor Registry of the United States, Hinsdale, IL, USA.

Purpose: Germ cell tumors (GCT) in the central nervous system (CNS) are rare tumors that occur with highest frequency in males, Asian populations, and children less than age 20 years. Due to the rarity of these tumors, their patterns of incidence are not well-described. The aim of this study is to provide the most up-to-date data on incidence and survival patterns for CNS GCT by sex, race, and age at diagnosis. Read More

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http://link.springer.com/10.1007/s11060-019-03173-4
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http://dx.doi.org/10.1007/s11060-019-03173-4DOI Listing
June 2019
25 Reads
3.070 Impact Factor

Redefining Ventricular Target Volume in Germinoma: Is Inclusion of Temporal Horns Necessary?

Int J Radiat Oncol Biol Phys 2019 07 30;104(4):852-858. Epub 2019 Mar 30.

Radiation Medicine Program, Princess Margaret Cancer Centre, University Health Network, Toronto, Canada; Division of Haematology/Oncology, Hospital for Sick Children, Toronto, Canada. Electronic address:

Purpose: We reviewed the outcomes of a retrospective germinoma cohort and analyzed radiation therapy plans to determine dosimetric differences for critical structures.

Methods And Materials: Data from pediatric patients treated with photon radiation for intracranial germinoma were analyzed for clinical outcomes and dosimetry to critical structures, with particular interest in the temporal ventricular horns (TVHs). A consensus contour was generated for TVH-sparing ventricular clinical target volumes (CTVs) via deformable image registration. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03603016193056
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http://dx.doi.org/10.1016/j.ijrobp.2019.03.039DOI Listing
July 2019
15 Reads

Pontomedullary germinoma with suprasellar and spinal metastasis: A report and comprehensive review of literature.

Neurol India 2019 Jan-Feb;67(1):308-311

Department of Neurosurgery, All India Institute of Medical Sciences, New Delhi, India.

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http://dx.doi.org/10.4103/0028-3886.253629DOI Listing
January 2020
3 Reads
1.084 Impact Factor

Granulomatous CNS inflammation associated with seminoma.

J Neurol 2019 Jun 11;266(6):1389-1393. Epub 2019 Mar 11.

Centre for Neurosarcoidosis, Neuroimmunology Unit, Institute of Immunity and Transplantation, University College London, London, NW3 2PF, UK.

Two cases in which a neurological disorder was identified pathologically to be due to a granulomatous infiltration were found after diagnosis to have an associated testicular seminoma with pathologically proven lymphatic metastasis. We present the clinical and imaging features, and pathological appearances of the lymphatic tissue and the brain. We summarise the literature to date and discuss the pathogenesis of the disorder and its treatment. Read More

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http://dx.doi.org/10.1007/s00415-019-09270-8DOI Listing
June 2019
24 Reads

Primary cavernous sinus germinoma with atypical extension pattern: a case report and review of the literature.

Childs Nerv Syst 2019 09 22;35(9):1615-1619. Epub 2019 Feb 22.

Department of Neurosurgery, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki, 305-8575, Japan.

Primary intracranial germinoma is a rare central nervous system tumor that usually arises in the pineal and the supra-sellar region. Here, we report a rare case of primary intracavernous sinus germinoma with an atypical extension pattern, with a comparison to germinomas originating from the cavernous sinus as described in the existing literature. A 12-year-old boy was admitted to our hospital with the chief complaint of the left-side ptosis and double vision. Read More

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http://dx.doi.org/10.1007/s00381-019-04092-5DOI Listing
September 2019
13 Reads

Bifocal germinoma in a patient with 16p11.2 microdeletion syndrome.

Endocrinol Diabetes Metab Case Rep 2019 Feb 7;2019. Epub 2019 Feb 7.

Department of Endocrinology, Diabetes and Metabolism.

Intracranial germinomas are rare tumors affecting mostly patients at young age. Therefore, molecular data on its etiopathogenesis are scarce. We present a clinical case of a male patient of 25 years with an intracranial germinoma and a 16p11. Read More

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http://dx.doi.org/10.1530/EDM-18-0149DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6373620PMC
February 2019
29 Reads

Germinoma Involving the Retina: An Unusual Presentation of Recurrent Intracranial Mixed Germ Cell Tumor.

World Neurosurg 2019 Jan 7. Epub 2019 Jan 7.

The Department of Pathology & Laboratory Medicine, Nationwide Children's Hospital, Columbus, OH 43205 and The Department of Pathology, The Ohio State University, College of Medicine, Columbus, OH 43210 USA.

Background: We report a patient with primary central nervous system mixed malignant germ cell tumor (GCT) who presented with recurrent malignant germinomatous infiltration of the retina.

Case Description: A ten-year-old girl initially presented with a large suprasellar mixed malignant GCT with a near-complete response after initial induction chemotherapy and irradiation. Three and half years after initial therapy, she presented with progressively worsening vision in her left eye. Read More

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http://dx.doi.org/10.1016/j.wneu.2018.12.143DOI Listing
January 2019
9 Reads
2.417 Impact Factor

Autopsy report of a late delayed radiation injury after a period of 45 years.

Neuropathology 2019 Apr 4;39(2):106-110. Epub 2019 Jan 4.

Faculty of Cancer Pathology, Hokkaido University Graduate School of Medicine, Sapporo, Japan.

For delayed radiation injury, image analysis has considerably advanced, but neuropathological findings are still required to establish diagnosis. A patient who had received radiation therapy for pineal germinoma at age 14 developed neurological and psychiatric abnormalities after 15 years as a late delayed radiation injury. Autopsy at age 59 revealed diffuse changes in the white matter consisting in order of severity of myelin pallor, demyelination, and necrosis which were characterized by a lack of glial reaction. Read More

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http://doi.wiley.com/10.1111/neup.12528
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http://dx.doi.org/10.1111/neup.12528DOI Listing
April 2019
32 Reads

Paraneoplastic recurrent tumefactive demyelination in a 62-year-old man with metastatic seminoma.

Neurol Neuroimmunol Neuroinflamm 2019 01 13;6(1):e527. Epub 2018 Dec 13.

Ottawa Hospital, Division of Neurology (S.T., P.R.B.); The Children's Hospital of Eastern Ontario (I.H.); The Ottawa Hospital (J.W.), Department of Pathology and Laboratory Medicine; and The Ottawa Hospital Research Institute (P.R.B.), ON, Canada.

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http://dx.doi.org/10.1212/NXI.0000000000000527DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299676PMC
January 2019
6 Reads

Pineal and Suprasellar Germinoma Cooccurence with Vertebra Plana: A Case Report.

Brain Tumor Res Treat 2018 Oct;6(2):73-77

Department of Neurosurgery, Mashhad University of Medical Sciences, Mashhad, Iran.

Germinoma is the most common type of intracranial germ cell tumors (GCTs). Pineal gland and suprasellar region are the most frequent sites of central nervous system (CNS) involvement. Intracranial masses caused by Langerhans cell histiocytosis (LCH) mimics features of CNS GCTs. Read More

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https://synapse.koreamed.org/DOIx.php?id=10.14791/btrt.2018.
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http://dx.doi.org/10.14791/btrt.2018.6.e9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6212690PMC
October 2018
15 Reads

Bilateral optic neuropathy with central diabetes insipidus in a child.

Indian J Ophthalmol 2018 Nov;66(11):1642-1644

Institute of Neuroscience, SIMS Hospitals, Chennai, Tamil Nadu, India.

Central nervous system germ cell tumors are rare and they occur in the first two decades of life. Optic nerve germinomas can sometimes mimic optic nerve inflammation. In this case report, we discuss an 11-year-old girl who presented with features of presumed bilateral optic neuritis and developed polyuria and polydipsia, subsequently she was diagnosed to have infiltrative etiology. Read More

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http://dx.doi.org/10.4103/ijo.IJO_281_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6213697PMC
November 2018
11 Reads

A systematic review of shunt-related extraneural metastases of primary central nervous system tumors.

Clin Neurol Neurosurg 2018 11 27;174:239-243. Epub 2018 Sep 27.

Department of Neurosurgery, University of North Carolina School of Medicine, Chapel Hill, North Carolina, United States. Electronic address:

Extraneural metastasis (ENM) of primary central nervous system (CNS) tumors is an uncommon occurrence. Case reports and case series describe ENM after shunting, but this phenomenon has not been well characterized. In this review we aim to better understand the risk factors and clinical implications of ENM associated with shunting. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03038467183040
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http://dx.doi.org/10.1016/j.clineuro.2018.09.038DOI Listing
November 2018
25 Reads

Seminoma with Neoplastic Meningitis Treated with Craniospinal Irradiation.

Oncologist 2018 11 16;23(11):1385-1387. Epub 2018 Jul 16.

Divisions of Hematology/Oncology and Neuro-Oncology, Massachusetts General Hospital, Boston, Massachusetts, USA.

Pure seminoma is a histological subtype of testicular cancer that accounts for 50% of testicular germ cell tumors. It has a very low rate of metastasis to the central nervous system, with only one previously reported case of neoplastic meningitis (cancer that has spread to the cerebrospinal fluid). Traditionally, neoplastic meningitis has an ominous prognosis when associated with primary tumors that commonly spread to the leptomeninges, like breast and lung. Read More

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http://theoncologist.alphamedpress.org/lookup/doi/10.1634/th
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http://dx.doi.org/10.1634/theoncologist.2017-0223DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6291321PMC
November 2018
18 Reads

[Preoperative and postoperative ophthalmic symptoms in patients with space-occupying lesions of the midbrain and pineal region].

Zh Vopr Neirokhir Im N N Burdenko 2018;82(3):42-47

Burdenko Neurosurgical Institute, 4-ya Tverskaya-Yamskaya Str., 16, Moscow, Russia, 125047.

The most common clinical manifestations of space-occupying lesions of the midbrain and pineal region are oculomotor and pupil disorders and ophthalmoscopic signs of intracranial hypertension.

Purpose: To identify patterns of neuro-ophthalmic symptoms before and after surgical treatment in patients with space-occupying lesions of the midbrain and pineal region.

Material And Methods: We analyzed neurological symptoms in 231 patients with space-occupying lesions of the midbrain and pineal region before and after surgical treatment. Read More

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http://dx.doi.org/10.17116/neiro201882342DOI Listing
June 2019
13 Reads

Suprasellar Germinomas: 2 Case Reports and Literature Review.

World Neurosurg 2018 Sep 15;117:165-171. Epub 2018 Jun 15.

Pathology Institute of Passo Fundo, Passo Fundo, Brazil.

Background: Germinomas are rare malignant central nervous system tumors, a type of germ cell tumor, according to the 2016 World Health Organization Classification of Brain Tumors. Most of these tumors develop along the midline, most often from the pineal gland, followed by tumors arising in the suprasellar cisterns. Suprasellar germinomas commonly manifest with diabetes insipidus, visual impairment, and hypothalamic-pituitary failure. Read More

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http://dx.doi.org/10.1016/j.wneu.2018.06.041DOI Listing
September 2018
36 Reads

Neuropsychological Consequences for Survivors of Childhood Brain Tumor in Malaysia.

Front Psychol 2018 29;9:703. Epub 2018 May 29.

Department of Clinical Child and Adolescent Studies, Faculty of Social Sciences, Leiden University, Leiden, Netherlands.

This study aimed to evaluate neuropsychological consequences in survivors of childhood brain tumor. A case-control study was conducted over a period of 4 months in a tertiary referral center in Kuala Lumpur, Malaysia. Fourteen survivors of childhood brain tumor aged 7-18 years, who were off-treatment for at least 1 year and were in remission, and 31 unrelated healthy controls were recruited. Read More

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http://dx.doi.org/10.3389/fpsyg.2018.00703DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5986920PMC
May 2018
19 Reads

[Thickening of the pituitary stalk in children and adolescents with central diabetes insipidus: Causes and consequences].

An Pediatr (Barc) 2019 May 9;90(5):293-300. Epub 2018 Jun 9.

Servicio de Pediatría y Endocrinología, Hospital Infantil Universitario Niño Jesús, Madrid, España; Departamento de Pediatría, Universidad Autónoma de Madrid, Madrid, España; CIBER Fisiopatología de la Obesidad y Nutrición, Instituto de Salud Carlos III, Madrid, España.; IMDEA Instituto de Alimentación, CEI UAM + CSIC, Madrid, España.

Background: Central diabetes insipidus (CDI) is a rare disorder in children. The aetiology of CDI in childhood is heterogeneous. The aim of this study is to illustrate the importance of a careful clinical and neuro-radiological follow-up of the pituitary and hypothalamus region in order to identify the aetiology and the development of associated hormonal deficiencies. Read More

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http://dx.doi.org/10.1016/j.anpedi.2018.05.002DOI Listing
May 2019
10 Reads

Central Nervous System Germ Cell Tumors: A Review of the Literature.

J Child Neurol 2018 08 30;33(9):610-620. Epub 2018 May 30.

1 Department of Neurosurgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Central nervous system germ cell tumors are rare intracranial tumors that mainly occur in pediatrics with substantial variation in the incidence among different regions and genders. Histologically, central nervous system germ cell tumors can be divided into germinomas and nongerminomatous germ cell tumors. The molecular pathology of central nervous system germ cell tumors, particularly germinomas, is mainly based on the presence of isochromosome 12p, gain-of-function of the KIT gene, and a globally low DNA methylation profile. Read More

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http://dx.doi.org/10.1177/0883073818772470DOI Listing
August 2018
26 Reads

Widespread Intra-abdominal Carcinomatosis from a Rhabdoid Meningioma after Placement of a Ventriculoperitoneal Shunt: A Case Report and Review of the Literature.

Asian J Neurosurg 2018 Apr-Jun;13(2):386-393

Department of Neurosurgery, University Surgical Cluster, National University Hospital, Singapore.

Intra-abdominal metastasis (IAM) of central nervous system (CNS) tumors through ventriculoperitoneal shunt (VPS) is rare but has been previously reported (e.g., germinomas and medulloblastomas). Read More

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http://dx.doi.org/10.4103/ajns.AJNS_42_15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5898111PMC
April 2018
16 Reads

Indications for salvage surgery during treatment for intracranial germ cell tumors.

J Neurooncol 2018 Jul 26;138(3):601-607. Epub 2018 Mar 26.

Department of Neurosurgery, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi, 980-8574, Japan.

This study retrospectively reviewed our single institute experience to clarify the optimal indication and timing of salvage surgery. Retrospective analysis of 159 consecutive cases with germ cell tumors identified 20 cases with salvage surgery. These cases were classified based on the radiological response to neoadjuvant treatment before salvage surgery into increase (growing group, five cases), no change (stable group, seven cases), and decrease (shrinkage group, eight cases) in tumor size. Read More

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http://dx.doi.org/10.1007/s11060-018-2827-3DOI Listing
July 2018
10 Reads

Widespread Intra-abdominal Carcinomatosis from a Rhabdoid Meningioma after Placement of a Ventriculoperitoneal Shunt: A Case Report and Review of the Literature.

Asian J Neurosurg 2018 Jan-Mar;13(1):176-183

Department of Neurosurgery, University Surgical Cluster, National University Health System, Singapore.

Intra-abdominal metastasis (IAM) of central nervous system (CNS) tumors via ventriculoperitoneal shunt (VPS) is rare but has been previously reported (e.g., germinomas and medulloblastomas). Read More

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http://dx.doi.org/10.4103/1793-5482.181128DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5820881PMC
March 2018
16 Reads

Central Nervous System Germinomas Express Programmed Death Ligand 1.

J Neuropathol Exp Neurol 2018 04;77(4):312-316

Department of Pathology (Neuropathology) and Neurological Surgery, University of Virginia, Charlottesville, Virginia.

Immunomodulation and tumor-induced tolerance is one of the central mechanisms in the oncogenesis of malignant and benign neoplasms. While numerous pathways have been described, signaling through the programmed death receptor 1 (PD-1) on T lymphocytes, via activation through its ligand, programmed death ligand 1 (PD-L1) expressed on tumor cells is one of the central pathways involved in tumor-induced tolerance. While the neoplastic component of germinomas of the CNS is the germ cell, these tumors also exhibit an abundance of quiescent tumor-infiltrating lymphocytes. Read More

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http://dx.doi.org/10.1093/jnen/nly008DOI Listing
April 2018
14 Reads

Evolution of Unilateral Basal Ganglia Lesion Over 16 Months.

JAMA Neurol 2018 03;75(3):376-377

Department of Radiology, People's Liberation Army General Hospital, Beijing, China.

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http://dx.doi.org/10.1001/jamaneurol.2017.4875DOI Listing
March 2018
2 Reads