1,006 results match your criteria Germinoma Central Nervous System


Bifocal germinoma in a patient with 16p11.2 microdeletion syndrome.

Endocrinol Diabetes Metab Case Rep 2019 Feb 7;2019. Epub 2019 Feb 7.

Department of Endocrinology, Diabetes and Metabolism.

Intracranial germinomas are rare tumors affecting mostly patients at young age. Therefore, molecular data on its etiopathogenesis are scarce. We present a clinical case of a male patient of 25 years with an intracranial germinoma and a 16p11. Read More

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http://dx.doi.org/10.1530/EDM-18-0149DOI Listing
February 2019
7 Reads

Germinoma Involving the Retina: An Unusual Presentation of Recurrent Intracranial Mixed Germ Cell Tumor.

World Neurosurg 2019 Jan 7. Epub 2019 Jan 7.

The Department of Pathology & Laboratory Medicine, Nationwide Children's Hospital, Columbus, OH 43205 and The Department of Pathology, The Ohio State University, College of Medicine, Columbus, OH 43210 USA.

Background: We report a patient with primary central nervous system mixed malignant germ cell tumor (GCT) who presented with recurrent malignant germinomatous infiltration of the retina.

Case Description: A ten-year-old girl initially presented with a large suprasellar mixed malignant GCT with a near-complete response after initial induction chemotherapy and irradiation. Three and half years after initial therapy, she presented with progressively worsening vision in her left eye. Read More

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http://dx.doi.org/10.1016/j.wneu.2018.12.143DOI Listing
January 2019
1 Read
2.417 Impact Factor

Pineal and Suprasellar Germinoma Cooccurence with Vertebra Plana: A Case Report.

Brain Tumor Res Treat 2018 Oct;6(2):73-77

Department of Neurosurgery, Mashhad University of Medical Sciences, Mashhad, Iran.

Germinoma is the most common type of intracranial germ cell tumors (GCTs). Pineal gland and suprasellar region are the most frequent sites of central nervous system (CNS) involvement. Intracranial masses caused by Langerhans cell histiocytosis (LCH) mimics features of CNS GCTs. Read More

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https://synapse.koreamed.org/DOIx.php?id=10.14791/btrt.2018.
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http://dx.doi.org/10.14791/btrt.2018.6.e9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6212690PMC
October 2018
5 Reads

Bilateral optic neuropathy with central diabetes insipidus in a child.

Indian J Ophthalmol 2018 Nov;66(11):1642-1644

Institute of Neuroscience, SIMS Hospitals, Chennai, Tamil Nadu, India.

Central nervous system germ cell tumors are rare and they occur in the first two decades of life. Optic nerve germinomas can sometimes mimic optic nerve inflammation. In this case report, we discuss an 11-year-old girl who presented with features of presumed bilateral optic neuritis and developed polyuria and polydipsia, subsequently she was diagnosed to have infiltrative etiology. Read More

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http://dx.doi.org/10.4103/ijo.IJO_281_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6213697PMC
November 2018
5 Reads

A systematic review of shunt-related extraneural metastases of primary central nervous system tumors.

Clin Neurol Neurosurg 2018 Nov 27;174:239-243. Epub 2018 Sep 27.

Department of Neurosurgery, University of North Carolina School of Medicine, Chapel Hill, North Carolina, United States. Electronic address:

Extraneural metastasis (ENM) of primary central nervous system (CNS) tumors is an uncommon occurrence. Case reports and case series describe ENM after shunting, but this phenomenon has not been well characterized. In this review we aim to better understand the risk factors and clinical implications of ENM associated with shunting. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03038467183040
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http://dx.doi.org/10.1016/j.clineuro.2018.09.038DOI Listing
November 2018
16 Reads

Suprasellar Germinomas: 2 Case Reports and Literature Review.

World Neurosurg 2018 Sep 15;117:165-171. Epub 2018 Jun 15.

Pathology Institute of Passo Fundo, Passo Fundo, Brazil.

Background: Germinomas are rare malignant central nervous system tumors, a type of germ cell tumor, according to the 2016 World Health Organization Classification of Brain Tumors. Most of these tumors develop along the midline, most often from the pineal gland, followed by tumors arising in the suprasellar cisterns. Suprasellar germinomas commonly manifest with diabetes insipidus, visual impairment, and hypothalamic-pituitary failure. Read More

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http://dx.doi.org/10.1016/j.wneu.2018.06.041DOI Listing
September 2018
15 Reads

Neuropsychological Consequences for Survivors of Childhood Brain Tumor in Malaysia.

Front Psychol 2018 29;9:703. Epub 2018 May 29.

Department of Clinical Child and Adolescent Studies, Faculty of Social Sciences, Leiden University, Leiden, Netherlands.

This study aimed to evaluate neuropsychological consequences in survivors of childhood brain tumor. A case-control study was conducted over a period of 4 months in a tertiary referral center in Kuala Lumpur, Malaysia. Fourteen survivors of childhood brain tumor aged 7-18 years, who were off-treatment for at least 1 year and were in remission, and 31 unrelated healthy controls were recruited. Read More

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http://dx.doi.org/10.3389/fpsyg.2018.00703DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5986920PMC
May 2018
9 Reads

Central Nervous System Germ Cell Tumors: A Review of the Literature.

J Child Neurol 2018 Aug 30;33(9):610-620. Epub 2018 May 30.

1 Department of Neurosurgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Central nervous system germ cell tumors are rare intracranial tumors that mainly occur in pediatrics with substantial variation in the incidence among different regions and genders. Histologically, central nervous system germ cell tumors can be divided into germinomas and nongerminomatous germ cell tumors. The molecular pathology of central nervous system germ cell tumors, particularly germinomas, is mainly based on the presence of isochromosome 12p, gain-of-function of the KIT gene, and a globally low DNA methylation profile. Read More

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http://dx.doi.org/10.1177/0883073818772470DOI Listing
August 2018
6 Reads

Widespread Intra-abdominal Carcinomatosis from a Rhabdoid Meningioma after Placement of a Ventriculoperitoneal Shunt: A Case Report and Review of the Literature.

Asian J Neurosurg 2018 Apr-Jun;13(2):386-393

Department of Neurosurgery, University Surgical Cluster, National University Hospital, Singapore.

Intra-abdominal metastasis (IAM) of central nervous system (CNS) tumors through ventriculoperitoneal shunt (VPS) is rare but has been previously reported (e.g., germinomas and medulloblastomas). Read More

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http://dx.doi.org/10.4103/ajns.AJNS_42_15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5898111PMC
April 2018
6 Reads

Widespread Intra-abdominal Carcinomatosis from a Rhabdoid Meningioma after Placement of a Ventriculoperitoneal Shunt: A Case Report and Review of the Literature.

Asian J Neurosurg 2018 Jan-Mar;13(1):176-183

Department of Neurosurgery, University Surgical Cluster, National University Health System, Singapore.

Intra-abdominal metastasis (IAM) of central nervous system (CNS) tumors via ventriculoperitoneal shunt (VPS) is rare but has been previously reported (e.g., germinomas and medulloblastomas). Read More

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http://dx.doi.org/10.4103/1793-5482.181128DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5820881PMC
March 2018
6 Reads

Central Nervous System Germinomas Express Programmed Death Ligand 1.

J Neuropathol Exp Neurol 2018 Apr;77(4):312-316

Department of Pathology (Neuropathology) and Neurological Surgery, University of Virginia, Charlottesville, Virginia.

Immunomodulation and tumor-induced tolerance is one of the central mechanisms in the oncogenesis of malignant and benign neoplasms. While numerous pathways have been described, signaling through the programmed death receptor 1 (PD-1) on T lymphocytes, via activation through its ligand, programmed death ligand 1 (PD-L1) expressed on tumor cells is one of the central pathways involved in tumor-induced tolerance. While the neoplastic component of germinomas of the CNS is the germ cell, these tumors also exhibit an abundance of quiescent tumor-infiltrating lymphocytes. Read More

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http://dx.doi.org/10.1093/jnen/nly008DOI Listing
April 2018
5 Reads

Intracranial germinoma causing cerebral haemiatrophy and hypopituitarism.

Pract Neurol 2018 Aug 29;18(4):306-310. Epub 2018 Jan 29.

Neurology Department, Hospital das Clínicas, Universidade de São Paulo, São Paulo, Brazil.

A young woman presented with primary amenorrhoea, progressive haemiparesis, visual disturbance, dementia and focal motor seizures. Investigations showed hypopituitarism, unilateral cerebral atrophy and inflamed cerebrospinal fluid. A trans-sphenoidal biopsy gave a unifying diagnosis of a pituitary germinoma. Read More

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http://dx.doi.org/10.1136/practneurol-2017-001771DOI Listing
August 2018
6 Reads

[A comparative analysis of anti-N-methyl-D-aspartate receptor encephalitis with or without abnormal findings on cranial magnetic resonance imaging].

Zhongguo Dang Dai Er Ke Za Zhi 2018 Jan;20(1):48-51

Children's Hospital Affiliated to Capital Institute of Pediatrics, Beijing 100020, China.

Objective: To investigate the clinical features of children with anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis with normal or abnormal cranial magnetic resonance imaging (MRI) findings via a comparative analysis.

Methods: A retrospective analysis was performed for the clinical data of 33 children with anti-NMDAR encephalitis. The clinical features and prognosis were compared between the children with normal and abnormal cranial MRI findings. Read More

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January 2018
14 Reads

Type, Frequency, and Spatial Distribution of Immune Cell Infiltrates in CNS Germinomas: Evidence for Inflammatory and Immunosuppressive Mechanisms.

J Neuropathol Exp Neurol 2018 Feb;77(2):119-127

Department of Neuropathology and Brain Tumor Reference Center, University of Bonn Medical Center, Bonn, Germany.

Central nervous system germinomas are characterized by a massive immune cell infiltrate. We systematically characterized these immune cells in 28 germinomas by immunophenotyping and image analysis. mRNA expression was analyzed by Nanostring technology and in situ RNA hybridization. Read More

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http://academic.oup.com/jnen/article/77/2/119/4728213
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http://dx.doi.org/10.1093/jnen/nlx106DOI Listing
February 2018
17 Reads

Third Ventricle Germ Cell Tumor Originating from the Infundibulum with Rapidly Expansive Enlargement.

Pediatr Neurosurg 2018 26;53(1):49-54. Epub 2017 Sep 26.

Department of Neurosurgery, Brain Research Institute, Niigata University, Niigata, Japan.

We present a pediatric case of a rapidly expanding third ventricle germ cell tumor (GCT). A 14-year-old boy suffered from gradual-onset central diabetes insipidus (DI) and received desmopressin treatment. Magnetic resonance imaging (MRI) showed nonspecific findings of the pituitary-hypothalamic axis. Read More

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http://dx.doi.org/10.1159/000480021DOI Listing
July 2018
11 Reads

Loco-regional extensions of central nervous system germ cell tumors: a retrospective radiological analysis of 100 patients.

Neuroradiology 2018 Jan 23;60(1):27-34. Epub 2017 Sep 23.

Imaging Department, Institut Curie, 26 rue d'Ulm, 75005, Paris, France.

Purpose: The current staging system of central nervous system (CNS) germ cell tumors (GCT) includes a binary classification in "localized" or "metastatic" disease based on the absence or presence of leptomeningeal dissemination. Loco-regional tumor dissemination has been barely described whereas its accurate definition might be useful in terms of prognosis and treatment, especially for radiation therapy planning. Our purpose was therefore to describe MR patterns and prevalence of loco-regional extensions of these tumors. Read More

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http://dx.doi.org/10.1007/s00234-017-1928-6DOI Listing
January 2018
21 Reads

Results of Combined Intraventricular Neuroendoscopic Procedures in 130 Cases with Special Focus on Fornix Contusions.

World Neurosurg 2017 Dec 18;108:817-825. Epub 2017 Sep 18.

Department of Neurosurgery, Medical School of the Saarland University, Homburg/Saar, Germany.

Objective: Increasing experience with intraventricular neuroendoscopic procedures shows good results in the combination of endoscopic third ventriculostomy (ETV) and tumor biopsy. Other possible combinations are mainly presented in subgroups in the literature. Here, we present our experience with combined intraventricular procedures within 1 setting over the last 2 decades. Read More

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http://dx.doi.org/10.1016/j.wneu.2017.09.045DOI Listing
December 2017
13 Reads

Craniospinal Germinomas in Patient with Down Syndrome Successfully Treated with Standard-Dose Chemotherapy and Craniospinal Irradiation: Case Report and Literature Review.

World Neurosurg 2017 Dec 12;108:995.e9-995.e15. Epub 2017 Sep 12.

Department of Neuro-Oncology/Neurosurgery, Saitama Medical University International Medical Center, Hidaka, Saitama, Japan.

Background: Patients with Down syndrome (DS) are more likely to develop chemotherapy-related complications. The standard treatment for these patients with cancer has not yet been established, and the risks of standard chemotherapy are unclear. In this paper, a rare case of multiple craniospinal germinomas in a patient with DS, which was successfully treated with standard-dose chemotherapy combined with craniospinal irradiation, is reported. Read More

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http://dx.doi.org/10.1016/j.wneu.2017.09.024DOI Listing
December 2017
4 Reads
2.420 Impact Factor

Primary Mediastinal Pure Seminomatous Germ Cell Tumor (Germinoma) as a Rare Cause of Precocious Puberty in a 9-Year-Old Patient.

Urology 2017 Dec 6;110:216-219. Epub 2017 Sep 6.

Division of Urology, Hospital Universitario San Ignacio and Pontificia Universidad Javeriana School of Medicine, Bogotá D.C., Colombia; Department of Urology, Hospital Universitario Fundación Santa Fe de Bogotá, Bogotá D.C., Colombia.

Less than 5%-7% of germ cell tumors are extragonadal, with the central nervous system being the most common location in children, followed by retroperitoneum and mediastinum. Only 10% of mediastinal tumors are malignant and one-third of these are pure seminomas (germinomas). We report the case of a 9-year-old boy with development of secondary sexual characteristics. Read More

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http://dx.doi.org/10.1016/j.urology.2017.08.038DOI Listing
December 2017
19 Reads

Regression of Pineal Lesions: Spontaneous or Iatrogenic? A Case Report and Systematic Literature Review.

World Neurosurg 2017 Dec 24;108:939-947.e1. Epub 2017 Aug 24.

Department of Neurosurgery, University Hospital Münster, Münster, Germany.

Background: Tumors arising from the pineal region account for approximately 1% of intracranial neoplasms. We present a case of a previously healthy 5-year-old boy with an acute onset of headache. A magnetic resonance imaging (MRI) scan showed a pineal mass with aqueduct compression. Read More

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http://dx.doi.org/10.1016/j.wneu.2017.08.106DOI Listing
December 2017
20 Reads

A 42-Year-Old Male with Diabetes Insipidus.

Brain Pathol 2017 09;27(5):695-696

Department of Neurosurgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

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http://dx.doi.org/10.1111/bpa.12541DOI Listing
September 2017
3 Reads

Histology-Stratified Tumor Control and Patient Survival After Stereotactic Radiosurgery for Pineal Region Tumors: A Report From the International Gamma Knife Research Foundation.

World Neurosurg 2017 Nov 24;107:974-982. Epub 2017 Jul 24.

Division of Neurosurgery, Department of Surgery, Université de Sherbrooke, Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, Québec, Canada. Electronic address:

Background: Pineal region tumors represent a rare and histologically diverse group of lesions. Few studies are available to guide management and the outcomes after stereotactic radiosurgery (SRS).

Methods: Patients who underwent SRS for a pineal region tumor and for whom at least 6 months of imaging follow-up was available were retrospectively assessed in 5 centers. Read More

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http://dx.doi.org/10.1016/j.wneu.2017.07.097DOI Listing
November 2017
83 Reads

Pitfalls of Neuroendoscopic Biopsy of Intraventricular Germ Cell Tumors.

World Neurosurg 2017 Oct 12;106:430-434. Epub 2017 Jul 12.

Department of Neurosurgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.

Objective: A neuroendoscopic biopsy has become common for the diagnosis of ventricular tumors. However, its utility in patients with germ cell tumors (GCTs) has not been well discussed. We examined the usefulness and pitfalls of neuroendoscopic biopsies of intraventricular GCTs at a single institution. Read More

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http://dx.doi.org/10.1016/j.wneu.2017.07.013DOI Listing
October 2017
16 Reads

Optimal radiotherapy target volumes in intracranial nongerminomatous germ cell tumors: Long-term institutional experience with chemotherapy, surgery, and dose- and field-adapted radiotherapy.

Pediatr Blood Cancer 2017 Nov 11;64(11). Epub 2017 Jul 11.

Department of Radiation Oncology, Mayo Clinic, Rochester, Minnesota.

Purpose: To evaluate patterns of failure after multimodality treatment of nongerminomatous germ cell tumors (NGGCTs).

Materials And Methods: We retrospectively reviewed records of 34 patients diagnosed with primary intracranial NGGCT between 1988 and 2014.

Results: Thirty-four patients received induction chemotherapy followed by radiation with or without surgery. Read More

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http://dx.doi.org/10.1002/pbc.26637DOI Listing
November 2017
12 Reads

A rare case report and literatures review on primary germinoma in cerebellar hemisphere.

Childs Nerv Syst 2017 Nov 8;33(11):2039-2045. Epub 2017 Jul 8.

Department of Pediatric Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100050, China.

Object: Primary intracranial germinoma is a rare intracranial lesion which accounts for approximately 0.5-2% of all intracranial tumors. Generally, primary intracranial germinoma occurs in the midline structures of the central nervous system of a pediatric patient. Read More

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http://dx.doi.org/10.1007/s00381-017-3502-2DOI Listing
November 2017
26 Reads

Intracranial Germinoma: Systemic Chemotherapy in Addition to Dose-Reduced Radiation Therapy.

Am J Ther 2017 Sep/Oct;24(5):e609-e610

1Department of Medicine, McGaw Medical Center of Northwestern University, Chicago, IL; 2Department of Neurology and Rehabilitation Medicine, University of Cincinnati Medical Center, Cincinnati, OH; and 3The Vontz Center for Molecular Studies, Cincinnati, OH.

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http://dx.doi.org/10.1097/MJT.0000000000000469DOI Listing
September 2018
3 Reads

MRI features of pediatric intracranial germ cell tumor subtypes.

J Neurooncol 2017 Aug 27;134(1):221-230. Epub 2017 May 27.

Department of Neurosurgery, Taipei Medical University Hospital, Taipei, Taiwan, ROC.

Intracranial germ cell tumors differ in histology and location, and require different clinical management strategies. We characterized the imaging features that may aid pre-operative differentiation of intracranial germinomas and non-germinomatous germ cell tumors (NGGCTs). This retrospective study analyzed 85 patients with intracranial germ cell tumors and adequate preoperative or pretreatment MRIs between 2000 and 2013 at our institution. Read More

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http://dx.doi.org/10.1007/s11060-017-2513-xDOI Listing
August 2017
21 Reads

[Recommendations for the organ donation from patients with brain or medullary primitive tumors on behalf of the Association of the Neuro-oncologists of French Expression (ANOCEF) and the Club of Neuro-oncology of the French Society of Neurosurgery].

Bull Cancer 2017 Sep 23;104(9):771-788. Epub 2017 May 23.

APHP, UMPC-Sorbonne universités, hôpital Pitié-Salpêtrière, 75013 Paris, France.

Requests of organs to be transplanted increase. As a matter of urgency, it is not always easy to decide if a patient carrier of a brain tumor can be candidate in the donation. After a review of the literature, the members of the Association of the Neuro-oncologists of French Expression (ANOCEF) and the Club of Neuro-oncology of the French Society of Neurosurgery propose consensual recommendations in case of donor carrier of primitive tumor intra-cranial or intra-medullary. Read More

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http://dx.doi.org/10.1016/j.bulcan.2017.02.007DOI Listing
September 2017
36 Reads

Holmes' tremor secondary to a posterior third ventricular germinoma: a rare case report.

Childs Nerv Syst 2017 Jun 3;33(6):885-887. Epub 2017 May 3.

Department of Neurosurgery, All India Institute of Medical Sciences, New Delhi, India.

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http://dx.doi.org/10.1007/s00381-017-3425-yDOI Listing

Clinical presentation and outcome of children with central diabetes insipidus associated with a self-limited or transient pituitary stalk thickening, diagnosed as infundibuloneurohypophysitis.

Clin Endocrinol (Oxf) 2017 Aug 5;87(2):171-176. Epub 2017 Jun 5.

Division of Pediatric Endocrinology, UZ Gent, Gent, Belgium.

Objective: Despite lymphocytic or autoimmune infundibuloneurohypophysitis (INH) is an increasingly recognized aetiology in children with central diabetes insipidus (CDI); clinical data on epidemiology (clinical evolution, predisposing factors, complications), diagnosis and management of this entity are limited and mostly based on published case reports. The aim of this study was to gain a broader insight in the natural history of this disease by analysing the clinical presentation, radiological pituitary stalk changes, associated autoimmunity and hormonal deficiencies in children with CDI and a self-limiting or transient stalk thickening (ST), diagnosed as autoimmune infundibuloneurohypophysitis, during the last 15 years in four Belgian university hospitals.

Design And Patients: The medical files of nine CDI patients with a ST at initial presentation and no signs of Langerhans cell histiocytosis or germinoma at presentation and/or during follow-up of more than 1. Read More

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http://dx.doi.org/10.1111/cen.13362DOI Listing
August 2017
2 Reads

Anomalous intracranial germinoma with unilateral cerebral peduncle swelling.

Childs Nerv Syst 2017 Apr 10;33(4):563-565. Epub 2017 Mar 10.

Neurosurgical Service, KK Women's and Children's Hospital (Singapore), 100 Bukit Timah Road, Singapore, 229899, Singapore.

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http://dx.doi.org/10.1007/s00381-017-3355-8DOI Listing
April 2017
6 Reads

Identification of characteristic features of pineal germinoma that enhance accuracy of preoperative differentiation in pineal region tumors: its significance on optimum surgical treatment.

Neurosurg Rev 2018 Jan 1;41(1):197-206. Epub 2017 Mar 1.

Department of Neurosurgery, Ehime University School of Medicine, 454 Shitsukawa, Toon, Ehime, 791-0295, Japan.

The aim of the study is to identify characteristic features of pineal germinoma that enhance preoperative accuracy in differentiating germinoma from other pineal region tumors. Twenty-one consecutive patients with pineal region tumors were enrolled. In all patients, tumor resection was performed to verify the histology. Read More

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http://dx.doi.org/10.1007/s10143-017-0835-yDOI Listing
January 2018
9 Reads

Pineal germ cell tumors: Two cases with review of histopathologies and biomarkers.

J Clin Neurosci 2017 Apr 8;38:23-31. Epub 2017 Feb 8.

Department of Neurosurgery, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, United States; Department of Radiation Oncology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, United States; Department of Head and Neck Surgery, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, United States; Jonsson Comprehensive Cancer Center, University of California, Los Angeles, Los Angeles, CA, United States. Electronic address:

Pineal germ cell tumors (GCTs) are primarily seen in pediatric and Asian populations. These tumors are divided into germinomatous and non-germinomatous GCTs (NGGCTs). GCTs are thought to arise by misplacement of totipotent stem cells en route to gonads during embryogenesis. Read More

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http://dx.doi.org/10.1016/j.jocn.2016.12.024DOI Listing
April 2017
10 Reads

Craniospinal irradiation using helical tomotherapy for central nervous system tumors.

J Radiat Res 2017 Mar;58(2):238-246

Department of Radiation Oncology, University Hospital of Heidelberg, Im Neuenheimer Feld 400, Heidelberg 69120, Germany.

The aim of this study was to describe early and late toxicity, survival and local control in 45 patients with primary brain tumors treated with helical tomotherapy craniospinal irradiation (HT-CSI). From 2006 to 2014, 45 patients with central nervous system malignancies were treated with HT-CSI. The most common tumors were medulloblastoma in 20 patients, ependymoma in 10 patients, intracranial germinoma (ICG) in 7 patients, and primitive neuroectodermal tumor in 4 patients. Read More

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http://dx.doi.org/10.1093/jrr/rrw095DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5439401PMC
March 2017
7 Reads

Transsphenoidal Posterior Pituitary Lobe Biopsy in Patients with Neurohypophysial Lesions.

World Neurosurg 2017 Mar 27;99:543-547. Epub 2016 Dec 27.

Department of Neurosurgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.

Objective: The differential diagnosis of neurohypophysial lesions is difficult, and surgical biopsies are indispensable in the histologic diagnosis of some patients. Although pituitary stalk biopsies are uniformly performed, there is a considerable risk that they will result in impaired hormonal secretion. We attempt to clarify the usefulness and safety of posterior pituitary lobe biopsy by transsphenoidal surgery (TSS). Read More

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http://dx.doi.org/10.1016/j.wneu.2016.12.080DOI Listing
March 2017
21 Reads

Primary Germinoma Originating from the Insular Lobe: A Case Report and Review of the Literature.

World Neurosurg 2017 Feb 19;98:871.e1-871.e7. Epub 2016 Dec 19.

Biomechanics and Medical Information Institute, Beijing University of Technology, Beijing, China.

Background: Primary intracranial germinomas occurring in the cerebral hemisphere are extremely rare, with only a few reported cases in the literature. We describe an unusual case of a primary germinoma that developed in the insular lobe, with little involvement in the basal frontal lobe.

Case Description: A 19-year-old man presented with headache and vomiting. Read More

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http://dx.doi.org/10.1016/j.wneu.2016.12.004DOI Listing
February 2017
17 Reads

Anti-pituitary antibodies against corticotrophs in IgG4-related hypophysitis.

Pituitary 2017 Jun;20(3):301-310

Department of Endocrinology and Diabetes, Nagoya University Graduate School of Medicine, Nagoya, 466-8550, Japan.

Purpose: IgG4-related disease is a systemic inflammatory disease characterized by infiltration of IgG4-positive plasma cells into multiple organs, including the pituitary gland. Autoimmunity is thought to be involved in the pathogenesis of IgG4-related disease. The diagnosis of IgG4-related hypophysitis (IgG4-RH) is difficult because its clinical features, such as pituitary swelling and hypopituitarism, are similar to those of other pituitary diseases, including lymphocytic hypophysitis and sellar/suprasellar tumors. Read More

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http://dx.doi.org/10.1007/s11102-016-0780-8DOI Listing
June 2017
4 Reads

Pediatric pineal germinomas: Epigenetic and genomic approach.

Clin Neurol Neurosurg 2017 Jan 19;152:45-51. Epub 2016 Nov 19.

Unidad de Investigación Médica en Genética Humana, Hospital de Pediatría "Dr. Silvestre Frenk Freud", Centro Médico Nacional "Siglo XXI", IMSS, Av. Cuauhtémoc 330, Col. Doctores, 06720, Del. Cuauhtémoc, México D.F., Mexico. Electronic address:

Objective: We identify and correlate chromosomal alterations, methylation patterns and gene expression in pediatric pineal germinomas.

Methods: CGH microarray, methylation and gene expression were performed through the Agilent platform. The results were analyzed with MatLab software, MapViewer, DAVID, GeneCards and Hippie. Read More

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http://dx.doi.org/10.1016/j.clineuro.2016.11.012DOI Listing
January 2017
16 Reads

Efficacy of Ifosfamide-Cisplatin-Etoposide (ICE) Chemotherapy for a CNS Germinoma in a Child With Down Syndrome.

J Pediatr Hematol Oncol 2017 01;39(1):e39-e42

Departments of *Pediatrics †Neurosurgery ‡Radiation Oncology and Image-Applied Therapy §Human Health Sciences, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

Intracranial germ cell tumor is sometimes associated with Down syndrome; however, no optimal treatment has been developed due to the high risk of recurrence and treatment-related mortality. Here, we report on a patient with an intracranial germinoma in the bilateral basal ganglia. The patient received 3 courses of ifosfamide-cisplatin-etoposide in combination with whole-brain irradiation (24 Gy), with no serious complications. Read More

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http://dx.doi.org/10.1097/MPH.0000000000000711DOI Listing
January 2017
10 Reads

Unusual cause of profound weight loss in a young woman.

BMJ Case Rep 2016 Nov 22;2016. Epub 2016 Nov 22.

Department of Endocrinology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.

A 27-year-old woman presented with anorexia, weight loss and psychiatric symptoms for the past 4 years. She did not have history of headache, visual disturbances or symptoms of raised intracranial pressure. She was sarcopenic with body mass index of 10. Read More

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http://dx.doi.org/10.1136/bcr-2016-218013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5129103PMC
November 2016
5 Reads

Successful treatment of Aspergillus ventriculitis through voriconazole adaptive pharmacotherapy, immunomodulation, and therapeutic monitoring of cerebrospinal fluid (1→3)-β-D-glucan.

Med Mycol 2017 Jan 12;55(1):109-117. Epub 2016 Nov 12.

Transplantation-Oncology Infectious Diseases Program and Infectious Diseases Translational Research Laboratory, Division of Infectious Diseases, Weill Cornell Medicine, New York, NY, USA

Aspergillus ventriculitis is an uncommon but often fatal form of invasive aspergillosis of the central nervous system (CNS). As little is known about the diagnosis, treatment, and outcome of this potentially lethal infection, we report the strategies used to successfully treat Aspergillus ventriculitis complicating a pineal and pituitary germinoma with emphasis on the critical role of adaptive pharmacotherapy of voriconazole and serial monitoring of (1→3)-β-D-glucan in cerebrospinal fluid. We describe several rationally based therapeutic modalities, including adaptive pharmacotherapy, combination therapy, sargramostim-based immunomodulation, and biomarker-based therapeutic monitoring of the CNS compartment. Read More

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http://dx.doi.org/10.1093/mmy/myw118DOI Listing
January 2017
12 Reads

Perifocal Inflammatory Reaction with Volume Fluctuation Caused by Diagnostic Radiation-Induced Regression in Germinoma Makes Histological Diagnosis Difficult despite Its Disappearance following Treatment: A Significant Pitfall and Countermeasures to It.

Pediatr Neurosurg 2017 11;52(2):87-92. Epub 2016 Nov 11.

Department of Neurosurgery, Uonuma Institute of Community Medicine, Niigata University Medical and Dental Hospital, Niigata, Japan.

We present a pediatric case of neurohypophyseal germinoma with a perifocal inflammatory reaction (PIR) with volume fluctuation caused by diagnostic radiation-induced regression (DRIR). On-target biopsy failed to confirm the histology because PIR hardly contained any germinoma cells. DRIR-related fluctuation of the tumor volume disguised germinoma as inflammation. Read More

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http://dx.doi.org/10.1159/000450583DOI Listing
March 2017
8 Reads

Spermatocytic Seminoma with Brain Metastasis.

Pathol Oncol Res 2017 Jan 4;23(1):223-224. Epub 2016 Nov 4.

Department of Urology, School of Medicine, Kyung Hee University, #149 Sangil-Dong, Gangdong-Gu, Seoul, 134-727, South Korea.

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http://dx.doi.org/10.1007/s12253-016-0142-xDOI Listing
January 2017
3 Reads

Case 32-2016. A 20-Year-Old Man with Gynecomastia.

N Engl J Med 2016 10;375(16):1567-1579

From the Departments of Radiation Oncology (S.M.M., N.J.T.), Radiology (O.R.), Pediatric Endocrinology (N.A.S.), Neurology (A.B.C.), Pediatric Hematology-Oncology (D.H.E.), and Pathology (D.H.O.), Massachusetts General Hospital, and the Departments of Radiation Oncology (S.M.M., N.J.T.), Radiology (O.R.), Pediatric Endocrinology (N.A.S.), Neurology (A.B.C.), Pediatric Hematology-Oncology (D.H.E.), and Pathology (D.H.O.), Harvard Medical School - both in Boston.

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http://dx.doi.org/10.1056/NEJMcpc1610098DOI Listing
October 2016
8 Reads

Intracranial germ cell tumors: a multi-institutional experience from three tertiary care centers in India.

Childs Nerv Syst 2016 Nov 30;32(11):2173-2180. Epub 2016 Jul 30.

Department of Pathology, All India Institute of Medical Sciences, New Delhi, 110029, India.

Objective: Central nervous system germ cell tumors (CNS GCTs) are relatively rare neoplasms. Incidence of CNS GCTs in Western literature is low (0.3-0. Read More

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http://dx.doi.org/10.1007/s00381-016-3167-2DOI Listing
November 2016
25 Reads

Disease characteristics and survival outcomes of extragonadal primary germ cell tumour in two Canadian tertiary cancer centres.

Can Urol Assoc J 2016 May-Jun;10(5-6):E165-E170. Epub 2016 May 12.

Department of Medical Oncology, Tom Baker Cancer Centre, Calgary, AB, Canada.

Introduction: Extragonadal germ cell tumours (EGCTs) are a heterogeneous group with distinct natural history and responses to treatment modalities. We sought to evaluate characteristics and survival outcomes in men with EGCTs.

Methods: We performed a retrospective analysis on a consecutive list of men diagnosed with EGCT in two Albertan cancer centres between 1990 and 2013. Read More

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http://dx.doi.org/10.5489/cuaj.3357DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5065405PMC
May 2016
24 Reads

A case of stroke-like migraine attacks after radiation therapy.

Headache 2017 Feb 20;57(2):283-284. Epub 2016 Oct 20.

Department of Medicine, Midland Regional Hospital, Mullingar, Ireland.

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http://dx.doi.org/10.1111/head.12967DOI Listing
February 2017
2 Reads

Outcomes for pediatric patients with central nervous system germ cell tumors treated with proton therapy.

Clin Transl Radiat Oncol 2016 Dec 26;1:9-14. Epub 2016 Sep 26.

Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, USA.

Purpose: We assessed outcomes after proton therapy (PT) for central nervous system germinomas or non-germinomatous germ cell tumors (NGGCTs) in children.

Patients And Methods: We identified children with germ cell tumors of the central nervous system who received proton therapy in 2006-2009 and extracted information on tumor response, treatment failures, and toxicity.

Results: Of the 20 identified patients (median age 12 years [range 3-16]), 9 had germinoma and 11 NGGCTs; 19 patients received three-dimensional conformal PT and 1 scanning-beam PT. Read More

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http://dx.doi.org/10.1016/j.ctro.2016.08.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5893478PMC
December 2016
1 Read