98,836 results match your criteria Geriatric Times[Journal]


TELOMERE LENGTH AND HEALTH OUTCOMES: AN UMBRELLA REVIEW OF SYSTEMATIC REVIEWS AND META-ANALYSES OF OBSERVATIONAL STUDIES.

Ageing Res Rev 2019 Feb 15. Epub 2019 Feb 15.

National Research Council, Neuroscience Institute, Aging Branch, Padova, Italy; Ambulatory of Nutrition, IRCCS "S. de Bellis" National Institute of Gastroenterology-Research Hospital Castellana Grotte Bari Italy, Italy. Electronic address:

The aim of the present study was to map and grade evidence for the relationships between telomere length with a diverse range of health outcomes, using an umbrella review of systematic reviews with meta-analyses. We searched for meta-analyses of observational studies reporting on the association of telomere length with any health outcome (clinical disease outcomes and intermediate traits). For each association, random-effects summary effect size, 95% confidence interval (CI), and 95% prediction interval were calculated. Read More

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http://dx.doi.org/10.1016/j.arr.2019.02.003DOI Listing
February 2019
4.940 Impact Factor

Hyperglycemia is associated with psoriatic inflammation in both humans and mice.

J Invest Dermatol 2019 Feb 15. Epub 2019 Feb 15.

Department of Immunology, Nagoya City University Graduate School of Medical Sciences, Nagoya 467-8601, Japan. Electronic address:

Chronic low-grade inflammation can cause several metabolic syndromes. Patients with psoriasis, a chronic immunological skin inflammation, often develop diabetes. However, it is not clear to date how psoriasis leads to, or is correlated with, glucose intolerance. Read More

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http://dx.doi.org/10.1016/j.jid.2019.01.029DOI Listing
February 2019

Small Molecule Amyloid-β Protein Precursor Processing Modulators Lower Amyloid-β Peptide Levels via cKit Signaling.

J Alzheimers Dis 2019 ;67(3):1089-1106

Department of Biochemistry, Boston University School of Medicine, Boston, MA, USA.

Alzheimer's disease (AD) is characterized by the accumulation of neurotoxic amyloid-β (Aβ) peptides consisting of 39-43 amino acids, proteolytically derived fragments of the amyloid-β protein precursor (AβPP), and the accumulation of the hyperphosphorylated microtubule-associated protein tau. Inhibiting Aβ production may reduce neurodegeneration and cognitive dysfunction associated with AD. We have previously used an AβPP-firefly luciferase enzyme complementation assay to conduct a high throughput screen of a compound library for inhibitors of AβPP dimerization, and identified a compound that reduces Aβ levels. Read More

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http://dx.doi.org/10.3233/JAD-180923DOI Listing
January 2019

Factors Associated with Length of Stay in Hospital Patients with and Without Dementia.

J Alzheimers Dis 2019 ;67(3):1055-1065

Network Aging Research, University of Heidelberg, Heidelberg, Baden-Wuerttemberg, Germany.

Background: Hospital care of older adults, especially of those with dementia, is associated with a high risk of complications and increased mortality. Adverse events are often triggered by hospital-related factors, hence the time spent in hospitals should be limited. There is little knowledge of the specific factors influencing hospitalizations of older persons. Read More

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http://dx.doi.org/10.3233/JAD-180593DOI Listing
January 2019

Therapeutic Potential of AMP-Activated Protein Kinase in Alzheimer's Disease.

J Alzheimers Dis 2019 Feb 13. Epub 2019 Feb 13.

Department of Internal Medicine, Gerontology & Geriatric Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA.

Currently there is no cure or effective disease-modifying therapy for Alzheimer's disease (AD), the most common form of dementia that is becoming a global threat to public health. It is important to develop novel therapeutic strategies targeting AD pathophysiology particularly synaptic failure and cognitive impairments. Recent studies revealed several molecular signaling pathways potentially linked to brain pathology and synaptic failure in AD, including AMP-activated protein kinase (AMPK), a master kinase that plays a central role in the maintenance of cellular energy homeostasis. Read More

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http://dx.doi.org/10.3233/JAD-181043DOI Listing
February 2019

Antiepileptic Drug Use Is Associated with an Increased Risk of Pneumonia Among Community-Dwelling Persons with Alzheimer's Disease-Matched Cohort Study.

J Alzheimers Dis 2019 Feb 11. Epub 2019 Feb 11.

School of Pharmacy, University of Eastern Finland, Kuopio, Finland.

Background: Antiepileptic drugs (AEDs) have sedative properties which may lead to an increased risk of pneumonia.

Objectives: To investigate whether incident AED use is associated with an increased risk of pneumonia among community-dwelling persons with Alzheimer's disease (AD). In addition, we determined the risk according to duration of AED use and specific AEDs. Read More

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http://dx.doi.org/10.3233/JAD-180912DOI Listing
February 2019

Distinctive Neurochemistry in Alzheimer's Disease via 7 T In Vivo Magnetic Resonance Spectroscopy.

J Alzheimers Dis 2019 Feb 11. Epub 2019 Feb 11.

Center for Magnetic Resonance Research and Department of Radiology, University of Minnesota, Minneapolis, MN, USA.

This study's objective was to increase understanding of biological mechanisms underlying clinical Alzheimer's disease (AD) by noninvasively measuring an expanded neurochemical profile and exploring how well this advanced technology distinguishes AD from cognitively normal controls. We measured concentrations of 14 neurochemicals using ultra-high field (7 T) ultra-short echo time (8 ms) magnetic resonance spectroscopy (MRS) in 16 participants with mild to moderate clinical AD and 33 age- and gender-matched control participants. MRS was localized to the posterior cingulate cortex (PCC), a region known to be impacted by AD, and the occipital cortex (OCC), a control region. Read More

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http://dx.doi.org/10.3233/JAD-180861DOI Listing
February 2019

Sweeteners modulate bioactivity of endothelial progenitor cells but not induce detrimental effects both on inflammation and behavioural changes.

Int J Food Sci Nutr 2019 Feb 18:1-13. Epub 2019 Feb 18.

a IRCCS SDN , Naples , Italy.

This study sought to determine the possible detrimental effects of several low- or non-caloric sweeteners on endothelial progenitor cells (EPCs), inflammation and behavioural changes in mice. C57BL/6 male mice received low and high dose of natural and artificial sweeteners for 4 weeks. EPCs, physical and biochemical variables, inflammation and behavioural changes were evaluated. Read More

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http://dx.doi.org/10.1080/09637486.2018.1563052DOI Listing
February 2019
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A coordination project for improvement of osteoporosis medication use among patients who sustained an osteoporotic fracture: The Israeli experience.

Osteoporos Sarcopenia 2018 Dec 30;4(4):134-139. Epub 2018 Nov 30.

Pat Matthews Academic School of Nursing, Hillel Yaffe Medical Center, Hadera, Israel.

Objectives: The aim of this study was to examine whether coordination between healthcare providers at an inpatient rehabilitation facility and healthcare providers in a community setting improves osteoporosis medication use in the community.

Methods: In 2012, a coordination project between an inpatient geriatric rehabilitation facility located in north-central Israel and general practitioners in the community setting was initiated. In this retrospective pseudo-experimental study, we compared osteoporosis medication use among patients who were hospitalized at the facility following an osteoporotic fracture during 2011-2012, and who constituted the control group (n=120), and patients who were hospitalized at the facility during 2013-2015, and who constituted the trial group (n=129). Read More

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http://dx.doi.org/10.1016/j.afos.2018.11.084DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372825PMC
December 2018

The development of Taiwan Fracture Liaison Service network.

Osteoporos Sarcopenia 2018 Jun 7;4(2):47-52. Epub 2018 Jun 7.

Superintendent Office, National Taiwan University Hospital Chu-Tung Branch, Hsinchu County, Taiwan.

Osteoporosis and its associated fragility fractures are becoming a severe burden in the healthcare system globally. In the Asian-Pacific (AP) region, the rapidly increasing in aging population is the main reason accounting for the burden. Moreover, the paucity of quality care for osteoporosis continues to be an ongoing challenge. Read More

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http://dx.doi.org/10.1016/j.afos.2018.06.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362955PMC

The impact of sarcopenia on the results of lumbar spinal surgery.

Osteoporos Sarcopenia 2018 Mar 11;4(1):33-36. Epub 2018 Mar 11.

Department of Orthopaedics, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan.

Objectives: As the population ages, the number of lumbar spinal surgeries performed on sarcopenic patients will increase. The purpose of this study was to investigate the prevalence of sarcopenia and evaluated its impact on the results of lumbar spinal surgery.

Methods: This study included 2 groups: One group consisted of patients who underwent whole-body dual-energy X-ray absorptiometry (DXA) scanning before the option of undergoing surgery for lumbar spinal disease (LSD group) and a second group consisted of patients underwent DXA scanning for osteoporosis screening under hospital watch at the geriatric medicine department (control group). Read More

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http://dx.doi.org/10.1016/j.afos.2018.02.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362951PMC

From brain collections to modern brain banks: A historical perspective.

Alzheimers Dement (N Y) 2019 5;5:52-60. Epub 2019 Feb 5.

University of Pavia, Pavia, Italy.

Our current knowledge of the structure, function, and diseases of the brain comes from direct examination of its substance. In the last centuries, only a few elite had managed to retrieve, gather, and preserve the elusive brain for their own research. The resulting brain collections, stored in formalin-filled jars or dried up in cabinets, served anatomical, neuropathological, anthropometric, ideological, and diagnostic purposes. Read More

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http://dx.doi.org/10.1016/j.trci.2018.12.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365388PMC
February 2019

Time Is Not More Abstract Than Space in Sound.

Front Psychol 2019 1;10:48. Epub 2019 Feb 1.

Department of Neurology, University of Pennsylvania, Philadelphia, PA, United States.

Time is talked about in terms of space more frequently than the other way around. Some have suggested that this asymmetry runs deeper than language. The idea that we think about abstract domains (like time) in terms of relatively more concrete domains (like space) but not can be traced to Conceptual Metaphor Theory. Read More

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http://dx.doi.org/10.3389/fpsyg.2019.00048DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367220PMC
February 2019

Comparison of health-related quality of life in patients with rheumatoid arthritis during conventional or conventional plus biological therapy in Poland.

Patient Prefer Adherence 2019 24;13:223-231. Epub 2019 Jan 24.

Department of Clinical Nursing Faculty of Health Sciences, Medical University, Wroclaw, Poland.

Purpose: The main purpose of this study was to compare the level of health-related quality of life (HRQoL) using Nottingham Health Profile (NHP) in Polish patients with rheumatoid arthritis (RA) during therapy applying disease-modifying antirheumatic drugs (DMARDs) with conventional synthetics (csDMARDs) or with csDMARDs in combination with biological drugs (bDMARDs). The second purpose was to analyze the correlation between the domain values of NHP and the demographic and clinical parameters, functional efficiency, and mood.

Patients And Methods: The studies involved 212 patients with RA, divided into two groups: group I - 126 persons treated using csDMARDs, group II - 86 patients using csDMARDs in combination with bDMARDs. Read More

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http://dx.doi.org/10.2147/PPA.S189152DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6352871PMC
January 2019

DAF-16 stabilizes the aging transcriptome and is activated in mid-aged Caenorhabditis elegans to cope with internal stress.

Aging Cell 2019 Feb 17:e12896. Epub 2019 Feb 17.

National Institute of Biological Sciences, Beijing, China.

The roles and regulatory mechanisms of transcriptome changes during aging are unclear. It has been proposed that the transcriptome suffers decay during aging owing to age-associated down-regulation of transcription factors. In this study, we characterized the role of a transcription factor DAF-16, which is a highly conserved lifespan regulator, in the normal aging process of Caenorhabditis elegans. Read More

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http://dx.doi.org/10.1111/acel.12896DOI Listing
February 2019

Sleep Quality, Duration, and Associated Sexual Function at Older Age: Findings from the English Longitudinal Study of Ageing.

J Sex Med 2019 Feb 14. Epub 2019 Feb 14.

Department of Behavioural Science and Health, University College London, London, United Kingdom.

Introduction: One factor that may plausibly be associated with sexual dysfunction is sleep disturbance. Like sexual problems, complaints of sleep disturbance increase with age and are commonly reported by older adults.

Aims: To examine associations between sleep quality, duration, and a range of sexual problems in a large, representative sample of older adults. Read More

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http://dx.doi.org/10.1016/j.jsxm.2019.01.005DOI Listing
February 2019
3.151 Impact Factor

Increasing postural sway in balance test is related to locomotive syndrome risk: A cross-sectional study.

J Orthop Sci 2019 Feb 14. Epub 2019 Feb 14.

Department of Orthopaedic Surgery, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan. Electronic address:

Background: Locomotive syndrome risk level has been recently proposed to evaluate physical ability. Impaired balance control is one of the most important risk factors for falls. However, the relationship between locomotive syndrome risk and postural sway according to the balance test is unclear. Read More

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http://dx.doi.org/10.1016/j.jos.2019.01.011DOI Listing
February 2019

Pharmacoepidemiology in older people: Purposes and future directions.

Therapie 2019 Jan 31. Epub 2019 Jan 31.

Aging Research Center, Karolinska Institutet, SE-171 77 Stockholm, Sweden.

Knowledge of the benefit/risk ratio of drugs in older adults is essential to optimise medication use. While randomised controlled trials are fundamental to the process of drug development and bringing new drugs to the market, they often exclude older adults, especially those suffering from frailty, multimorbidity and/or receiving polypharmacy. Therefore, it is generally unknown whether the benefits and harms of drugs established through pre-marketing clinical trials are translatable to the real-word population of older adults. Read More

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http://dx.doi.org/10.1016/j.therap.2018.10.006DOI Listing
January 2019

A year in review in Minerva Anestesiologica 2018.

Minerva Anestesiol 2019 Feb;85(2):206-220

Department of Anesthesiology and Critical Care Medicine, University Hospital Dresden, Dresden, Germany.

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http://dx.doi.org/10.23736/S0375-9393.19.13597-3DOI Listing
February 2019

Functional characterization of AC5 gain-of-function variants: Impact on the molecular basis of ADCY5-related dyskinesia.

Biochem Pharmacol 2019 Feb 14. Epub 2019 Feb 14.

Purdue University, Medicinal Chemistry and Molecular Pharmacology, 575 Stadium Mall Drive, West Lafayette, IN, 47907; Purdue Institute for Integrative Neuroscience, Hall for Discovery Learning - #399, 207 South Martin Jischke Drive, West Lafayette, IN. 47907; Purdue Institute for Drug Discovery, 720 Clinic Drive, West Lafayette, IN. 47907. Electronic address:

Adenylyl cyclases are key points for the integration of stimulatory and inhibitory G protein-coupled receptor (GPCR) signals. Adenylyl cyclase type 5 (AC5) is highly expressed in striatal medium spiny neurons (MSNs), and is known to play an important role in mediating striatal dopaminergic signaling. Dopaminergic signaling from the D expressing MSNs of the direct pathway, as well as the D expressing MSNs of the indirect pathway both function through the regulation of AC5 activity, controlling the production of the 2 messenger cAMP, and subsequently the downstream effectors. Read More

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http://dx.doi.org/10.1016/j.bcp.2019.02.005DOI Listing
February 2019

Medication-related risk factors and its association with repeated hospital admissions in frail elderly: A case control study.

Res Social Adm Pharm 2019 Feb 13. Epub 2019 Feb 13.

University of Bradford, School of Pharmacy and Medical Sciences, Bradford, UK.

Background: Repeated hospital admissions are prevalent in older people. The role of medication in repeated hospital admissions has not been widely studied. The hypothesis that medication-related risk factors for initial hospital admissions were also associated with repeated hospital admissions was generated. Read More

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http://dx.doi.org/10.1016/j.sapharm.2019.02.001DOI Listing
February 2019

Continuing pharmacy education practices in geriatric care among pharmacists in the Upper Midwest.

J Am Pharm Assoc (2003) 2019 Feb 13. Epub 2019 Feb 13.

Objectives: To summarize select continuing pharmacy education (CPE) topics and hours related to geriatric care completed by community, hospital/clinic, and long-term care (LTC)/consultant pharmacists in the previous 12 months, whether pharmacy workplace influenced topic selection or completion, and to describe CPE sources used by community versus hospital/clinic pharmacists.

Design: Cross-sectional survey (2017).

Setting And Participants: Licensed pharmacists in North Dakota, South Dakota, Minnesota, Iowa, and Nebraska with primary practice settings in community pharmacies, hospitals, or clinics or those practicing as consultant pharmacists. Read More

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http://dx.doi.org/10.1016/j.japh.2018.12.020DOI Listing
February 2019

The relationship between lower extremity swelling, quadriceps strength, and functional performance following total knee arthroplasty.

Knee 2019 Feb 13. Epub 2019 Feb 13.

The University of Colorado Denver AMC, Department of Physical Medicine and Rehabilitation, United States of America; Veterans Affairs Geriatric Research, Education and Clinical Center, Denver, CO, United States of America.

Background: The relationships between swelling after total knee arthroplasty (TKA) and quadriceps strength and functional performance are poorly understood. Therefore, the aim of this study was to examine the relationships between lower extremity swelling, measured using bioelectrical impedance assessment (SF-BIA), and quadriceps strength and timed up and go (TUG) times following TKA.

Methods: 53 participants (64 ± 9. Read More

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http://dx.doi.org/10.1016/j.knee.2019.01.012DOI Listing
February 2019

Predictive Capacity of Frailty Phenotype Toward Patterns of Disability Identified Using Latent Class Analysis.

J Am Med Dir Assoc 2019 Feb 13. Epub 2019 Feb 13.

Geriatric Unit, Campus Bio-Medico University, Rome, Italy.

Objectives: Frailty phenotype (FP) has low sensitivity toward the identification of older people who will lose 1 or more activities of daily living. Nevertheless, the definition of disability in terms of activities of daily living may not resemble the pattern of functional impairment occurring during aging. The aim of this study was to examine the discriminative capacity of the FP toward the identification of patterns of disabilities in an extended list of tasks, identified among community-dwelling older people. Read More

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http://dx.doi.org/10.1016/j.jamda.2018.12.018DOI Listing
February 2019

Impact of Perceived Racism on Healthcare Access Among Older Minority Adults.

Am J Prev Med 2019 Feb 14. Epub 2019 Feb 14.

Social and Behavioral Sciences Department, Yale School of Public Health, New Haven, Connecticut; Department of Psychology, Graduate School of Arts and Sciences, Yale University, New Haven, Connecticut.

Introduction: Older minority individuals are less likely to receive adequate health care than their white counterparts. This study investigates whether perceived racism is associated with delayed/forgone care among minority older adults, and whether poor doctor communication mediates this relationship.

Methods: Study cohort consisted of minority participants, aged ≥65 years, in the 2015 California Health Interview Survey (N=1,756). Read More

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http://dx.doi.org/10.1016/j.amepre.2018.10.010DOI Listing
February 2019

Older ovarian cancer survivors report lower long-term health-related quality of life than younger survivors: A study from the population-based profiles registry.

Gynecol Oncol 2019 Feb 13. Epub 2019 Feb 13.

CoRPS - Center of Research on Psychology in Somatic Diseases, Department of Medical and Clinical Psychology, Tilburg University, the Netherlands; Netherlands Comprehensive Cancer Organisation, the Netherlands.

Objective: To assess long-term differences in health-related quality of life (HRQoL) of older ovarian cancer survivors compared to both an age-matched normative population and to younger survivors. In addition, the differential effect of chemotherapy on HRQoL between older and younger survivors was compared.

Methods: Ovarian cancer survivors (n = 348) diagnosed between 2000 and 2010, as registered by the Dutch population-based Eindhoven Cancer Registry, were invited to complete the EORTC QLQ-C30 HRQoL questionnaire in 2012. Read More

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http://dx.doi.org/10.1016/j.ygyno.2019.02.001DOI Listing
February 2019

Chronic exposure to microcystin-LR reduces thyroid hormone levels by activating p38/MAPK and MEK/ERK signal pathway.

Ecotoxicol Environ Saf 2019 Feb 13;173:142-148. Epub 2019 Feb 13.

Department of Geriatric Endocrinology, Geriatric Hospital of Nanjing Medical University, Luojia Road 30, Nanjing 210024, China. Electronic address:

Microcystin-LR (MC-LR) is the most toxic and abundant microcystin that produced by cyanobacteria. Previous studies have shown MC-LR had acute toxic to thyroid, however, the mechanism is still unclear, and the effect of long-term, low-dose MC-LR on thyroid remains uncertain. In this study, we investigated the chronic, low-dose effect of MC-LR on mouse thyroid tissues and thyroid hormone metabolism. Read More

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http://dx.doi.org/10.1016/j.ecoenv.2019.02.024DOI Listing
February 2019

A modified Delphi and cross-sectional survey to facilitate selection of optimal outcomes and measures for a systematic review on geriatrician-led care models.

J Clin Epidemiol 2019 Feb 13. Epub 2019 Feb 13.

Li Ka Shing Knowledge Institute of St. Michael's Hospital, Toronto, Ontario; Division of Geriatric Medicine, Department of Medicine, University of Toronto, Ontario. Electronic address:

Objective: To identify relevant outcomes and measures to inform a systematic review (SR) on the comparative effectiveness of geriatrician-led care models.

Study Design And Setting: In the modified Delphi to select outcomes for inclusion in the SR, knowledge users (KU) from Ontario, Alberta and Saskatchewan rated outcome importance using a Likert scale. A survey was then completed by geriatricians to determine optimal measures for selected outcomes. Read More

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http://dx.doi.org/10.1016/j.jclinepi.2019.02.005DOI Listing
February 2019

Evaluating the properties of a frailty index and its association with mortality risk among patients with systemic lupus erythematosus.

Arthritis Rheumatol 2019 Feb 16. Epub 2019 Feb 16.

Division of Rheumatology, Department of Medicine and Department of Pathology, Queen Elizabeth II Health Sciences Center and Dalhousie University, Halifax, Nova Scotia, Canada.

Objective: To evaluate the properties of a frailty index (FI), constructed using data from the Systemic Lupus International Collaborating Clinics (SLICC) inception cohort, as a novel health measure in SLE.

Methods: For this secondary analysis, the baseline visit was defined as the first study visit at which both organ damage (SLICC/ACR Damage Index [SDI]) and health-related quality of life (Short-Form 36 [SF-36]) were assessed. The SLICC-FI was constructed using baseline data. Read More

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http://doi.wiley.com/10.1002/art.40859
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http://dx.doi.org/10.1002/art.40859DOI Listing
February 2019
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Frailty score for elderly patients is associated with short-term clinical outcomes in patients with ST-segment elevated myocardial infarction treated with primary percutaneous coronary intervention.

Neth Heart J 2019 Feb 15. Epub 2019 Feb 15.

Department of Cardiology, Leiden University Medical Centre, Leiden, The Netherlands.

Objective: Consistent with the aging population in the Western world, there is a growing number of elderly patients with ST-segment elevation myocardial infarction (STEMI). Primary percutaneous coronary intervention (PCI) is the recommended reperfusion strategy in elderly patients; risk models to determine which of these patients are prone to have poor clinical outcomes are, however, essential. The purpose of this study was to assess the association between frailty and short-term mortality and PCI-related serious adverse events (SAE) in elderly patients. Read More

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http://dx.doi.org/10.1007/s12471-019-1240-7DOI Listing
February 2019

Diabetes Management in Older Adults With Chronic Kidney Disease.

Curr Diab Rep 2019 Feb 15;19(3):11. Epub 2019 Feb 15.

Department of Medicine, Division of Nephrology, Stanford University School of Medicine, Stanford, CA, USA.

Purpose Of Review: Older adults often live with chronic disease including diabetes and its complications. In this review, we examine the complexity and heterogeneity of older adults with diabetes and chronic kidney disease, explore the nuances in their diabetes-related monitoring, and discuss their best diabetes management.

Recent Findings: Although there remains an overall lack of studies in older adults with diabetes and chronic kidney disease, recent reports have highlighted their vulnerabilities. Read More

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http://dx.doi.org/10.1007/s11892-019-1128-3DOI Listing
February 2019

Spatiotemporal gait analysis of older persons in clinical practice and research : Which parameters are relevant?

Authors:
Ulrich Lindemann

Z Gerontol Geriatr 2019 Feb 15. Epub 2019 Feb 15.

Department of Clinical Gerontology and Rehabilitation, Robert-Bosch-Hospital, Auerbachstr. 110, 70376, Stuttgart, Germany.

For older persons walking is a basic activity of daily life which characterizes the person's functional mobility. Therefore, the improvement of walking performance is a major clinical outcome during geriatric rehabilitation. Furthermore, walking performance is relevant for several geriatric research issues. Read More

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http://dx.doi.org/10.1007/s00391-019-01520-8DOI Listing
February 2019

The feasibility of assessing frailty and sarcopenia in hospitalised older people: a comparison of commonly used tools.

BMC Geriatr 2019 Feb 15;19(1):42. Epub 2019 Feb 15.

Academic Geriatric Medicine, University of Southampton, Southampton, UK.

Background: Frailty and sarcopenia are common amongst hospitalised older people and associated with poor healthcare outcomes. Widely recognised tools for their identification are the Fried Frailty Phenotype, its self-report version the FRAIL Scale, and the European Working Group on Sarcopenia in Older People (EWGSOP) criteria. We studied the feasibility of using these tools in a hospital setting of acute wards for older people. Read More

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http://dx.doi.org/10.1186/s12877-019-1053-yDOI Listing
February 2019

Motor neuron disease-associated loss of nuclear TDP-43 is linked to DNA double-strand break repair defects.

Proc Natl Acad Sci U S A 2019 Feb 15. Epub 2019 Feb 15.

Department of Radiation Oncology, Houston Methodist Research Institute, Houston, TX 77030;

Genome damage and their defective repair have been etiologically linked to degenerating neurons in many subtypes of amyotrophic lateral sclerosis (ALS) patients; however, the specific mechanisms remain enigmatic. The majority of sporadic ALS patients feature abnormalities in the transactivation response DNA-binding protein of 43 kDa (TDP-43), whose nucleo-cytoplasmic mislocalization is characteristically observed in spinal motor neurons. While emerging evidence suggests involvement of other RNA/DNA binding proteins, like FUS in DNA damage response (DDR), the role of TDP-43 in DDR has not been investigated. Read More

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http://www.pnas.org/lookup/doi/10.1073/pnas.1818415116
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http://dx.doi.org/10.1073/pnas.1818415116DOI Listing
February 2019
3 Reads

Lactate and NEWS-L are fair predictors of mortality in critically ill geriatric emergency department patients.

Am J Emerg Med 2019 Feb 7. Epub 2019 Feb 7.

Emergency Medicine Department, Necmettin Erbakan University Meram Faculty of Medicine, Konya, Turkey.

Introduction: In this study, we aimed to investigate the prognostic power of the first lactate level measured in the emergency department (ED), National Early Warning Score (NEWS), and NEWS-lactate (NEWS-L) on ED admission in critically ill geriatric patients.

Methods: This retrospective observational study was conducted in the ED of a university hospital. Consecutive patients ≥65 years of age admitted to our ED between July 1, 2017, and December 31, 2017, and transferred to the intensive care unit after the ED follow-up period were included in the study. Read More

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http://dx.doi.org/10.1016/j.ajem.2019.02.006DOI Listing
February 2019

Increasing Social Activities Reduces Depression in Old Age, but Which Activities Matter?

Authors:
Gary J Kennedy

Am J Geriatr Psychiatry 2019 Jan 17. Epub 2019 Jan 17.

Division of Geriatric Psychiatry (GJK), Albert Einstein College of Medicine, Montefiore Medical Center, 111 East 210th St., Bronx, NY 10467. Electronic address:

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http://dx.doi.org/10.1016/j.jagp.2019.01.011DOI Listing
January 2019

Two years supervised resistance training prevented diabetes incidence in people with prediabetes: a randomized control trial.

Diabetes Metab Res Rev 2019 Feb 15:e3143. Epub 2019 Feb 15.

Jiangsu Province Hospital on Integration of Chinese and Western Medicine affiliated with Nanjing University of Chinese Medicine, Nanjing, China.

Aim: To explore the long-term effects of aerobic training (AT), resistance training (RT) and combined training (AT+RT) on the prevention of T2D incidence in patients with prediabetes.

Materials And Methods: In this randomized controlled trial, people with prediabetes (fasting glucose ≥5.6 mmol/L and <7. Read More

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http://dx.doi.org/10.1002/dmrr.3143DOI Listing
February 2019

The Acute Inflammatory Response after Trauma is heightened by Frailty: A Prospective Evaluation of Inflammatory and Endocrine System Alterations in Frailty.

J Trauma Acute Care Surg 2019 Feb 13. Epub 2019 Feb 13.

Division of Trauma, Critical Care, Emergency Surgery, and Burns, Department of Surgery, University of Arizona, College of Medicine, Tucson, Arizona.

Introduction: Frailty is a geriatric syndrome characterized by decreased physiological reserves, increased inflammation, and decreased anabolic-endocrine response. The biomarkers associated with frailty are poorly understood in trauma. The aim of this study was to analyze the association between frailty and immune: IL-1β, IL-6, IL-2Rα, TNF-α and endocrine biomarkers: Insulin-like growth factor-1(IGF-1), and growth hormone(GH) in trauma patients. Read More

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http://dx.doi.org/10.1097/TA.0000000000002229DOI Listing
February 2019
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Dispersal of gram-negative bacilli from contaminated sink drains to cover gowns and hands during hand washing.

Infect Control Hosp Epidemiol 2019 Feb 15:1-3. Epub 2019 Feb 15.

Geriatric Research, Education, and Clinical Center,Louis Stokes Cleveland VA Medical Center,Cleveland, Ohio.

We demonstrated that hand washing resulted in frequent dispersal of gram-negative bacilli from colonized sink drains in hospitals to cover gowns and hands. A plastic drain cover reduced but did not eliminate the risk for contamination. This mechanism of dispersal could result in contamination of healthcare personnel and patients. Read More

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http://dx.doi.org/10.1017/ice.2019.25DOI Listing
February 2019

Inflammatory biomarkers, depressive symptoms and falls among the elderly in Panama.

Curr Aging Sci 2019 Feb 15. Epub 2019 Feb 15.

Centro de Neurociencias y Unidad de Investigación Clínica, Instituto de Investigaciones Científicas y Servicios de Alta Tecnología (INDICASAT AIP), Ciudad del Saber. Panama.

Background: Falls are common among elderly adults, and are predictors of hospitalization, institutionalization and mortality.

Objective: The objective of the present study was to examine the relationship between blood-based markers of inflammation and fall events in a sample of elderly Hispanic adults.

Method: Data were collected from 190 participants enrolled in the Panama Aging Research Initiative study who completed baseline clinical and cognitive assessments. Read More

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http://dx.doi.org/10.2174/1874609812666190215125104DOI Listing
February 2019

Impregnated acetate gauze compared with lipido-colloid contact layer at dressing removal pain: a single-blind cross-over randomised control trial.

J Wound Care 2019 Feb;28(2):89-101

Dermatologist; Dermatology and out-patients consultations, Hôpital Dupuytren, Limoges, France.

Objective:: To evaluate the performance of Jelonet Plus (JP) and UrgoTul (UT), assessing pain at dressing removal when managing acute or chronic wounds at granulation and epithelialisation stages.

Methods:: This was a randomised, multicentre, controlled single-blinded study using a cross-over design. Hospitalised and ambulatory patients presenting with non-infected acute or chronic wounds (at least 40% of wound area of ≤100cm covered with granulation tissue) were randomly allocated to be treated with either JP or UT dressings applied according to a standardised local care procedure for two days. Read More

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http://dx.doi.org/10.12968/jowc.2019.28.2.89DOI Listing
February 2019

Progressive brain atrophy in chronically infected and treated HIV+ individuals.

J Neurovirol 2019 Feb 14. Epub 2019 Feb 14.

Department of Public Health, Infection Unit, Tufts University School of Medicine, Boston, MA, USA.

Growing evidence points to persistent neurological injury in chronic HIV infection. It remains unclear whether chronically HIV-infected individuals on combined antiretroviral therapy (cART) develop progressive brain injury and impaired neurocognitive function despite successful viral suppression and immunological restoration. In a longitudinal neuroimaging study for the HIV Neuroimaging Consortium (HIVNC), we used tensor-based morphometry to map the annual rate of change of regional brain volumes (mean time interval 1. Read More

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http://dx.doi.org/10.1007/s13365-019-00723-4DOI Listing
February 2019

Transurethral resection of the prostate with preservation of the bladder neck decreases postoperative retrograde ejaculation.

Wideochir Inne Tech Maloinwazyjne 2019 Jan 14;14(1):96-101. Epub 2018 Nov 14.

Department of Geriatric Medicine, Xiang Ya Hospital, Central South University, Changsha, China.

Introduction: Even though transurethral resection of the prostate (TURP) is the standard surgical treatment for benign prostatic hyperplasia (BPH), there is a high rate of postoperative retrograde ejaculation.

Aim: To evaluate the effectiveness of TURP with preservation of the bladder neck in comparison with that of standard TURP.

Material And Methods: This is a retrospective study. Read More

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http://dx.doi.org/10.5114/wiitm.2018.79536DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372866PMC
January 2019

Motoric Cognitive Risk Syndrome: Could It Be Defined Through Increased Five-Times-Sit-to-Stand Test Time, Rather Than Slow Walking Speed?

Front Aging Neurosci 2018 23;10:434. Epub 2019 Jan 23.

Division of Geriatric Medicine, Department of Medicine, Sir Mortimer B. Davis - Jewish General Hospital and Lady Davis Institute for Medical Research, McGill University, Montreal, QC, Canada.

Slow walking speed, time to perform the five-times-sit-to-stand (FTSS) test and motoric cognitive risk syndrome (MCR; defined as slow gait speed combined with subjective cognitive complaint) have been separately used to screen older individuals at risk of cognitive decline. This study seeks to (1) compare the characteristics of older individuals with MCR, as defined through slow walking speed and/or increased FTSS time; and (2) examine the relationship between MCR and its motor components as well as amnestic (a-MCI) and non-amnestic (na-MCI) Mild Cognitive Impairment. A total of 633, individuals free of dementia, were selected from the cross-sectional "Gait and Alzheimer Interactions Tracking" study. Read More

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http://dx.doi.org/10.3389/fnagi.2018.00434DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366305PMC
January 2019

Accessibility and Uptake of Pre-Exposure Prophylaxis for HIV Prevention in the Veterans Health Administration.

Fed Pract 2018 Mar;35(Suppl 2):S42-S48

is the Deputy Director and the National Infectious Diseases Officer for the Veterans Health Administration, Office of Specialty Care Services, HIV, Hepatitis, and Related Conditions Programs (HHRC). and are Data Analysts for the HHRC Data and Analytics Group and Data Analysts for the Health Services Research and Development at VA Puget Sound Healthcare System. is a Staff Physician and the Director of the VA National Liver Disease Database at VA Puget Sound Healthcare System, the Director of the HHRC Data Analytics Group, and Assistant Professor of Medicine in the Division of General Internal Medicine at the University of Washington in Seattle. is a Staff Physician in the Geriatric Research Education and Clinical Center, Division of Infectious Diseases at Louis Stokes Cleveland VAMC and an Assistant Professor in the Department of Internal Medicine, Division of Infectious Diseases at Case Western Reserve University School of Medicine, both in Cleveland, Ohio. is an Investigator at the Center for Access and Delivery Research and Evaluation at Iowa City VA Health Care System and an Associate Professor in the University of Iowa Department of Medicine. is a staff physician in the Infectious Diseases Section of the VA Portland Healthcare System and an Assistant Professor, at Oregon Health and Sciences University in the Division of Infectious Diseases, both in Portland.

To increase access, the National PrEP Working Group is expanding outreach outside of primary care and among nonspecialists, ensuring uniformly high-quality care and targeting high-risk populations. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6375402PMC

Setting and Method of Measurement Affect Blood Pressure Readings in Older Veterans.

Fed Pract 2018 Jun;35(6):16-21

is a Medical Student at Florida International University Herbert Wertheim College of Medicine in Miami. is the Clinical Director of the Geriatric Research, Education, and Clinical Center; is Director and is a Kinesiology Exercise Specialist of the Gerofit Program; and is a Research Associate, all at Greater Los Angeles VA Healthcare System in California. is an Associate Professor of Medicine, and Dr. Castle is a Professor of Medicine at the David Geffen School of Medicine at UCLA.

The present study demonstrated that standardized measurements of blood pressure were lower than the routine method used in most office settings. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368018PMC

Providing Rural Veterans With Access to Exercise Through Gerofit.

Fed Pract 2018 Nov;35(11):16-23

is an Exercise Physiologist, is a Biostatistician, and is a Physician and the Director of Geriatric Research and Education at the Salem VAMC in Virginia. is Associate Director of Research in the Geriatric Research, Education, and Clinical Center (GRECC) at Durham VAMC in North Carolina. is an Exercise Physiologist and is a Physician in the GRECC at the Greater Los Angeles VAHS in California. is a physician in the GRECC at the Miami VAHS in Florida. Dr. Morey is a Professor at Duke University Medical Center in Durham. Dr. Lee is an Associate Professor at the David Geffen School of Medicine at University of California Los Angeles. Dr. Valencia is an Assistant Professor at University of Miami Miller School of Medicine and Florida International University in Miami, Florida. Dr. Oursler is an Associate Professor at Virginia Tech Carilion School of Medicine in Roanoke, Virginia.

Clinical video telehealth can be used to deliver functional circuit exercise training to older veterans in remote locations. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366594PMC
November 2018

Sex-specific association between soluble corin and metabolic syndrome in Chinese adults.

Hypertens Res 2019 Feb 14. Epub 2019 Feb 14.

Department of Epidemiology, School of Public Health and Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University, Suzhou, China.

Soluble corin has been associated with cardiovascular disease and its risk factors, but whether it is associated with metabolic syndrome (MetS), a cluster of cardiometabolic disorders, remains unclear. We aimed to examine the association between soluble corin and MetS in Chinese men and women. We examined serum soluble corin using immunoassays in 962 men (mean age, 53 years) and 1536 women (mean age, 54 years) free of cardiovascular disease. Read More

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http://dx.doi.org/10.1038/s41440-019-0228-4DOI Listing
February 2019