97,479 results match your criteria Geriatric Times[Journal]
Liver Int 2018 Dec 16. Epub 2018 Dec 16.
Laboratory for the identification of prognostic factors of response to the treatment against infectious diseases, University of Campania, Naples, Italy.
Aim: The aim of the present study was to identify, among the patients with failure to DAA regimen, those with a late relapse (after the achievement of a sustained virological response at week 12) and to characterize the clinical, epidemiological and virological features of these patients.
Material And Methods: 129 HCV patients with non-response to an IFN-free regimen were enrolled. Sanger sequencing of NS3, NS5A and NS5B was performed at failure by home-made protocols. Read More
Inflammation 2018 Dec 15. Epub 2018 Dec 15.
Department of Cardiology, Zhejiang Hospital, 12 Lingyin Road, Zhejiang, Hangzhou, China.
The administration of cannabinoid receptor 2 (CB2R) agonist has been reported to produce a cardioprotective effect against the pathogenesis and progression of myocardial infarction (MI). Here in this study, we investigated the specific mechanism related to inflammatory suppression. JWH-133 was used for the activation of CB2R. Read More
Nephron 2018 Dec 14:1-9. Epub 2018 Dec 14.
Department of Renal Medicine, Lancashire Teaching Hospitals NHS Foundation Trust, Preston, United Kingdom.
Background/aims: Frail patients with chronic kidney disease (CKD) have an increased hospitalisation and mortality rate. However, many popular frailty screening methods have not been validated in patients with CKD. This study evaluates the diagnostic accuracy of several frailty screening methods in patients with CKD G4-5 and those established on haemodialysis (G5D). Read More
Drug Alcohol Depend 2018 Dec 8;195:1-5. Epub 2018 Dec 8.
Columbia University, Department of Epidemiology, Mailman School of Public Health, New York, NY, USA.
Background: Benzodiazepine overdose rates have increased in the US, largely from concomitant use of other drugs such as opioids. Studies are needed to examine trends in prescription tranquilizer (e.g. Read More
Pharmacol Res 2018 Dec 13. Epub 2018 Dec 13.
Department of Pharmacy, Xiangya Hospital, Central South University, Changsha, 410008, China; National Clinical Research Center for Geriatric Disorders (XIANGYA), Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China. Electronic address:
Stress response refers to the systemic nonspecific response upon exposure to strong stimulation or chronic stress, such as severe trauma, shock, infection, burn, major surgery or improper environment, which disturb organisms and damage their physical and psychological health. However, the pathogenesis of stress induced disorder remains complicated and diverse under different stress exposure. Recently, studies have revealed a specific role of microRNAs (miRNAs) in regulating cellular function under different types of stress, suggesting a significant role in the treatment and prevention of stress-related diseases, such as stress ulcer, posttraumatic stress disorder, stress-induced cardiomyopathy and so on. Read More
Biol Psychol 2018 Dec 13. Epub 2018 Dec 13.
Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Baltimore, MD, USA.
Objective: Studies have linked self-reported discrimination to telomere attrition, a biological marker of accelerated cellular aging. However, it is unknown whether intersections between social categories-race, socioeconomic status (SES), sex, and age-influence the association of varying forms of discrimination with telomere length. We examined these associations in a socioeconomically and racially/ethnically diverse urban sample. Read More
Clin Nutr 2018 Nov 30. Epub 2018 Nov 30.
Servicio de Geriatría, Hospital Universitario Ramón y Cajal (IRYCIS), Madrid, Spain. Electronic address:
Recent definitions of malnutrition include low muscle mass within its diagnostic criteria. In fact, malnutrition is one of the main risk factors of skeletal muscle loss contributing to the onset of sarcopenia. However, differences in the screening and diagnosis of skeletal muscle loss, especially as a result of malnutrition in clinical and community settings, still occur mainly as techniques and thresholds used vary in clinical practice. Read More
Neuroimage 2018 Dec 12. Epub 2018 Dec 12.
Center for Biomedical Imaging Research, Department of Biomedical Engineering, School of Medicine, Tsinghua University, Beijing, China. Electronic address:
Reduction in cerebral blood flow (CBF), one of the major metrics for cerebral perfusion, is associated with many brain disorders. Therefore, early characterization of CBF prior to occurrence of symptoms is essential for prevention of cerebral ischemic disorders. We hypothesized that large artery atherosclerosis might be a potential indicator for decline in cerebral perfusion. Read More
Neurosci Biobehav Rev 2018 Dec 12. Epub 2018 Dec 12.
Institute of Neuroscience, Newcastle University Institute of Ageing, Newcastle Upon Tyne, UK; Newcastle Upon Tyne Hospital NHS Foundation Trust, UK. Electronic address:
Gait is complex, described by diverse characteristics underpinned by widespread central nervous system networks including motor and cognitive functions. Despite this, neural substrates of discrete gait characteristics are poorly understood, limiting understanding of gait impairment in ageing and disease. This structured review aims to map gait characteristics, defined from a pre-specified model reflecting independent gait domains, to brain imaging parameters in older adults. Read More
Eur J Pharmacol 2018 Dec 12. Epub 2018 Dec 12.
Department of Physiology, Shiga University of Medical Science, Otsu, Japan. Electronic address:
The human Kv1.5 channel (hKv1.5) produces the ultrarapid delayed rectifier potassium current (I), which is important for determining the repolarization of action potential in the cardiac atrium. Read More
Diabet Med 2018 Dec 15. Epub 2018 Dec 15.
Department of Social Sciences and Health Policy, Wake Forest School of Medicine.
Aims: To examine (1) the prevalence of depressive symptoms in women with Type 2 diabetes, (2) the associations between depressive symptoms and the following dependent variables: sleep disturbance; physical activity; physical health-related; and global quality of life, and (3) the potential moderating effects of antidepressants and optimism on the relationship between depressive symptoms and dependent variables.
Methods: Participants in the Women's Health Initiative who had Type 2 diabetes and data on depressive symptoms (N=8895) were included in the analyses. In multivariable linear regression models controlling for sociodemographic, medical and psychosocial covariates, we examined the main effect of depressive symptoms, as well as the interactions between depressive symptoms and antidepressant use, and between depressive symptoms and optimism, on sleep disturbance, physical activity, physical health-related quality of life and global quality of life. Read More
J Gastroenterol Hepatol 2018 Dec 14. Epub 2018 Dec 14.
Department of Gastroenterology, The Second Military Medical University, Shanghai, China.
Background & Aims: Pancreatic extracorporeal shock wave lithotripsy (P-ESWL) is first-line treatment for chronic pancreatitis (CP) patients with pancreatic stones. However, the performance of P-EWSL in geriatric patients remains unclear. We aimed to evaluate the safety and efficacy of P-ESWL for them. Read More
Cancer Treat Res 2019 ;171:21-35
Department of Medicine, Northwestern University, Chicago, IL, USA.
Cancer is primarily a disease of aging. This chapter discusses relevant aspect of the physiology of aging, medication use and toxicity, comorbidities, and specific challenges in treating older adults with cancer. Read More
Biomol NMR Assign 2018 Dec 14. Epub 2018 Dec 14.
Department of Chemistry and Biochemistry, Miami University, 651 E. High St, Oxford, OH, 45056, USA.
The ever-increasing occurrence of antibiotic resistance presents a major threat to public health. Specifically, resistance conferred by β-lactamases places the efficacy of currently available antibiotics at risk. Klebsiella pneumoniae carbapenemase-2 (KPC-2) is a β-lactamase that enables carbapenem resistance and represents a clear and present danger to global public health. Read More
Aging Clin Exp Res 2018 Dec 14. Epub 2018 Dec 14.
Department of Electrophysiology, Heart Center of Leipzig, Leipzig, Germany.
Background: Cardiac implantable electronic devices (CIEDs) are widely used to treat bradyarrhythmias or improve the prognosis of patients with heart failure (HF).
Aims: To evaluate age-related (≤ 75 vs. > 75 years) attitudes, worries, psychological effects and needs in an Italian CIEDs population. Read More
Eur Radiol 2018 Dec 14. Epub 2018 Dec 14.
Department of Radiological, Oncological and Pathological Sciences, Sapienza University of Rome "Sapienza", Viale Regina Elena 324, 00161, Rome, Italy.
Objectives: To investigate the prognostic role of early post-infarction cardiac magnetic resonance (CMR) on long-term risk stratification of ST segment elevation myocardial infarction (STEMI) patients with preserved left ventricular ejection fraction (LVEF).
Methods: Seventy-seven STEMI patients treated by primary percutaneous coronary intervention (PCI) and LVEF > 50% at CMR were included. The median time between STEMI and CMR was 5 days (IQR 2-8). Read More
Neurology 2018 Dec 14. Epub 2018 Dec 14.
From the Department of Epidemiology (C.Z., Z.Z., A.W., Tan Xu, X.B., H.P., J.Y., L.H., Tian Xu, Y.Z.), School of Public Health and Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University, Suzhou, China; Department of Epidemiology (C.Z., J.C., J.H.), Tulane University School of Public Health and Tropical Medicine, New Orleans, LA; Department of Epidemiology (J.Y.), School of Public Health, Guizhou Medical University, Guiyang; Department of Preventive Medicine (L.H.), Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine, Ningbo University, Ningbo, China; Department of Medicine (J.C., J.H.), Tulane University School of Medicine, New Orleans, LA; Department of Neurology (Tian Xu), Affiliated Hospital of Nantong University, Nantong; Department of Neurology (Y.P.), Affiliated Hospital of North China University of Science and Technology; Department of Neurology (J.W.), Yutian County Hospital, Tangshan; Department of Epidemiology (Q.L.), School of Public Health, Taishan Medical College, Taian; Department of Neurology (Z.J.), Kerqin District First People's Hospital of Tongliao City, Tongliao; and Department of Neurology (D.G.), Affiliated Hospital of Xuzhou Medical College, Xuzhou, China.
Objective: To study the prognostic significance of multiple novel biomarkers in combination after ischemic stroke.
Methods: We derived data from the China Antihypertensive Trial in Acute Ischemic Stroke, and 12 informative biomarkers were measured. The primary outcome was the combination of death and major disability (modified Rankin Scale score ≥3) at 3 months after ischemic stroke, and secondary outcomes included major disability, death, and vascular events. Read More
BMJ Open 2018 Dec 14;8(12):e023803. Epub 2018 Dec 14.
Department of Geriatric Medicine, Odense University Hospital, Odense, Denmark.
Objectives: The objective was to describe the prevalence of geriatric conditions among older medical patients in the emergency department (ED) and the association with admission, mortality, reattendance and loss of independency.
Design: Population-based prospective cohort study.
Setting: ED of a large university hospital. Read More
J Am Med Dir Assoc 2018 Dec 11. Epub 2018 Dec 11.
Department of Geriatrics and Aging Research, University Hospital Zurich and University of Zurich, Switzerland; Centre on Aging and Mobility, University Hospital Zurich and City Hospital Waid Zurich, Switzerland; University Clinic for Acute Geriatric Care, City Hospital Waid, Zurich, Switzerland. Electronic address:
Objectives: To evaluate 2 simple strategies, vitamin D and a home exercise program, in functional recovery during the first year after hip fracture.
Design: Secondary analysis of a factorial clinical trial. Patients were randomly allocated to 800 IU (standard of care) or 2000 IU vitamin D and a daily instruction of a simple home exercise program (SHEP) or standard physiotherapy alone during acute care. Read More
Clin Nutr 2018 Dec 1. Epub 2018 Dec 1.
Department of Neurosciences and Aging, Division of Geriatric Medicine, Angers University Hospital, Angers University Memory Clinic, Research Center on Autonomy and Longevity, UPRES EA 4638, University of Angers, UNAM, Angers, France; Robarts Research Institute, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada.
Background: The European Society of Clinical Nutrition and Metabolism (ESPEN) has developed a consensus definition of malnutrition. This study aimed to determine the prevalence of malnutrition according to the ESPEN definition in otherwise healthy community-dwelling older women and to explore its value for predicting long-term mortality in this population.
Methods: This prospective population-based cohort study included 181 women (age ≥75 years) from a subsample of the EPIDémiologie de l'OStéoporose (EPIDOS) study participants from Toulouse. Read More
Biomed Pharmacother 2019 Jan 9;109:1319-1326. Epub 2018 Nov 9.
Department of Geriatric Medicine, The Affiliated Hospital of Qingdao University, Qingdao 266003, China. Electronic address:
Perivascular inflammation, vascular luminal area reduction and hemodynamics changes are important pathophysiologic bases of pulmonary hypertension (PH). In this study, PH was induced by an intraperitoneal single injection of monocrotaline (MCT, 60 mg/kg). Alginate oligosaccharides (AOS), one of the most famous marine drugs, provided protections in the perivascular inflammation, vascular luminal area reduction and hemodynamics changes of the PH rat induced by MCT. Read More
Biomed Pharmacother 2019 Jan 6;109:1140-1147. Epub 2018 Nov 6.
Department of Hepatobiliary Surgery, the First Affiliated Hospital of Xi'an Jiaotong University, 277 Yanta West Road, Xi'an, Shaanxi Province, 710061, China. Electronic address:
Long non-coding RNAs (lncRNAs) are critical regulators in the tumorigenesis and metastasis of hepatocellular carcinoma (HCC). LncRNA KTN1 antisense RNA 1 (KTN1-AS1) has been reported to play an important role in colorectal cancer and correlates with unfavorable clinical outcomes of head and neck squamous cell carcinoma. However, the clinical significance and functional role of KTN1-AS1 in HCC are still unclear. Read More
Exp Gerontol 2018 Dec 11. Epub 2018 Dec 11.
Unit for Aging Brain and Dementia, Department of Geriatric Medicine, Faculty of Medicine, Dokuz Eylul University, Izmir, Turkey.
It is not known whether undernutrition causes vitamin B12 and folate deficiencies. The present study aimed to determine whether nutritional status, measured using the Mini Nutritional Assessment (MNA) scale, and body mass index (BMI) are indicators of lower level serum vitamin B12 and folate in older adults. 1007 outpatients aged 65 years or over were included the study. Read More
J Nurs Care Qual 2018 Dec 12. Epub 2018 Dec 12.
Department of Medicine (Drs Krol, Jolly Graham, and White and Mr English), Center for Advanced Clinical Practice (Ms Allen), and Duke University School of Nursing (Ms Matters), Duke University Medical Center, Durham, North Carolina.
Background: Individuals discharged from the hospital to skilled nursing facilities (SNFs) experience high rates of unplanned hospital readmission, indicating opportunity for improvement in transitional care.
Local Problem: Local physicians providing care in SNFs were not associated with the discharging hospital health care system. As a result, substantive real-time communication between hospital and SNF physicians was not occurring. Read More
Am J Phys Med Rehabil 2018 Dec 13. Epub 2018 Dec 13.
Department of surgery, Academic Medical Center, Amsterdam, The Netherlands.
Objective: The preoperative phase is a potential window of opportunity. Although frail elderly patients are known to be more prone to postoperative complications, they are often not considered capable of accomplishing a full prehabilitation program. The aim of this study was to assess the feasibility of Fit4SurgeryTV, an at-home prehabilitation program specifically designed for frail elderly with colorectal cancer (CRC). Read More
Curr Opin Lipidol 2018 Dec 12. Epub 2018 Dec 12.
Geriatric Research, Education, and Clinical Center, Veterans Affairs Puget Sound Healthcare System.
Purpose Of Review: Various groups have explored the effect of apolipoprotein E (APOE) on neurodegeneration through nutritional and metabolic alterations. In this review, we hope to summarize recent findings in humans as well as preclinical APOE models.
Recent Findings: Metabolic pathways including lipid metabolism appear to play a large role in the pathophysiology of Alzheimer's disease. Read More
Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Oct;32(19):1464-1468
Department of Otorhinolaryngology, Beijing Shijitan Hospital, Affiliated to Capital Medical University.
To analyze the dynamic changes of the clinical features of chronic rhinosinusitis in recent 10 years, so as to deeply understand the characteristics of chronic rhinosinusitis, and to provide new ideas for treatment of chronic rhinosinusitis. This retrospective study was performed in patients who were diagnosed as chronic rhinosinusitis and enrolled. General information, clinical examination and pathological results were all collected, then patients' age, gender, the incidence of asthma and allergic rhinitis, peripheral eosinophil percentage, olfactory dysfunction and pathological results were statistically analyzed. Read More
J Clin Psychiatry 2018 Nov 27;80(1). Epub 2018 Nov 27.
Division of Geriatric Psychiatry, Sunnybrook Health Sciences Centre and University of Toronto, Toronto, Ontario, Canada.
Objective: Late-life depression has been associated with increased risk of mild cognitive impairment (MCI) and dementia. Predictors of increased risk are incompletely understood. Identification of potentially modifiable risk factors could facilitate prevention of MCI and dementia. Read More
J Clin Psychiatry 2018 Dec 4;80(1). Epub 2018 Dec 4.
Department of Neuropsychiatry, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan.
Objective: Placebo effects remain largely unexplored in clinical trials of long-acting injectable (LAI) antipsychotics for schizophrenia. This study aims to characterize patients showing improvements after placebo injections and to search for criteria for the prediction of subsequent response based on the magnitude of score changes after the first week of treatment.
Methods: Data from 450 patients with schizophrenia (DSM-IV) who received placebo injections in 4 double-blind randomized controlled trials evaluating efficacy of LAI paliperidone palmitate obtained through the Yale University Open Data Access (YODA) project were analyzed. Read More
J Clin Psychiatry 2018 Dec 4;80(1). Epub 2018 Dec 4.
Columbia University College of Physicians and Surgeons, New York State Psychiatric Institute, New York, USA.
Background: According to prevailing models and classical reports, abrupt responses to antidepressant medication are not true drug responses but rather transient placebo effects. By contrast, recent reports suggest that early sudden improvements have a lasting effect and appear in most patients receiving medication. Clinical guidelines influenced by these contradictory findings are mixed and confusing. Read More
J Clin Psychiatry 2018 Nov 20;79(6). Epub 2018 Nov 20.
Institute for Clinical Evaluative Sciences, London, Ontario, Canada.
Objective: Lithium is an effective treatment for mood disorders, but lithium level and renal monitoring every 3 months is recommended in older patients treated with lithium to prevent serious adverse events. This study examined lithium monitoring practices in a large geriatric cohort.
Methods: This population-based cohort study (N = 11,006) used linked health care administrative databases. Read More
J Adv Nurs 2018 Dec 14. Epub 2018 Dec 14.
Warwick Research in Nursing, University of Warwick and Oxford Trauma, Kadoorie Centre, NDORMS, University of Oxford and Oxford University Hospitals NHS Trust.
Aim: To explore assessment on a hospital ward for older people from the perspectives of patients and healthcare professionals.
Design: A qualitative study drawing on grounded theory was undertaken between February 2015 - January 2016.
Methods: Interviews with 15 patients and 22 healthcare professionals, a focus group with six healthcare professionals, 45 hours of observation and review of 18 sets of patient notes. Read More
Ann Neurol 2018 Dec 14. Epub 2018 Dec 14.
Harvard Aging Brain Study, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Objectives: Amyloid-beta (Aβ) and tau pathologies are commonly observed among clinically normal older individuals at post-mortem and can now be detected with in vivo neuroimaging. The association and interaction of these proteinopathies with prospective cognitive decline in normal aging and preclinical Alzheimer's disease (AD) remains to be fully elucidated.
Methods: One hundred and thirty-seven older individuals (age=76. Read More
Diabetes Metab Res Rev 2018 Dec 13:e3116. Epub 2018 Dec 13.
Division of Family Medicine, Department of Family and Community Medicine, Tri-Service General Hospital; and School of Medicine, National Defense Medical Center, Taipei, Taiwan, Republic of China.
Objective To elucidate whether the PF-combined definition of metabolic syndrome (MetS) would show a better predictive ability for cause-specific mortality than the common MetS. Methods The data were derived from the National Health and Nutrition Examination Survey from 1999 through 2002. We investigated three types of MetS including WCMetS, PFMetS, and PF-combined definition MetS. Read More
Geriatr Gerontol Int 2018 Dec;18(12):1655
Unit of Geriatric Medicine, University Campus Biomedico, Rome, Italy.
Geriatr Gerontol Int 2018 Dec;18(12):1652-1653
Unit of Geriatrics, Department of Internal Medicine, Azienda Ospedaliera di Cosenza, Cosenza, Italy.
Geriatr Gerontol Int 2018 Dec;18(12):1647-1648
Geriatric Unit, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
Geriatr Gerontol Int 2018 Dec 12. Epub 2018 Dec 12.
Geriatric Unit, Internal Medicine Department, Bellvitge University Hospital-IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain.
Aim: To assess whether 1-year mortality in older patients experiencing a first admission for acute heart failure was related to sex, and to explore differential characteristics according to sex.
Methods: We reviewed the medical records of 1132 patients aged >70 years of age admitted within a 3-year period because of a first episode of acute heart failure. We analyzed sex differences. Read More
Psychogeriatrics 2018 Dec 13. Epub 2018 Dec 13.
School of Psychology, University of Queensland, Brisbane, St Lucia, Queensland, Australia.
Dementia is a neurocognitive disorder that affects a person's abilities in daily functioning. Anxiety and depression symptoms are common among persons with dementia. Cognitive behavioural therapy (CBT) has been tested to manage their depression and anxiety symptoms. Read More
J Am Geriatr Soc 2018 Dec 13. Epub 2018 Dec 13.
Division of Public Health Sciences, Washington University School of Medicine, St Louis, Missouri.
Background/objectives: The incidence of myeloma in older adults is increasing, yet little is known about geriatric impairments in these patients. We aimed to examine the prevalence of geriatric impairments in older adults with myeloma and the association between geriatric assessment and autologous stem cell transplant eligibility.
Design: Prospective cohort study. Read More
J Am Geriatr Soc 2018 Dec 12. Epub 2018 Dec 12.
Department of Anesthesiology and Pain Medicine, University of Washington, Seattle, Washington.
Objectives: To determine the prevalence and impact of common co-occurring symptoms among community-dwelling older adults in the United States.
Design: The National Health and Aging Trends Study is a nationally representative, prospective study with annual data collection between 2011 and 2017.
Setting: Community-based, in-person interviews (survey response rates, 71%-96%). Read More
Public Health Nurs 2018 Dec 11. Epub 2018 Dec 11.
Nell Hodgson Woodruff School of Nursing, Emory University, Atlanta, Georgia.
Objective: To increase our understanding about the health beliefs of African-American parents and their daughters toward HPV infection and HPV vaccine acceptance.
Methods: The Health Belief Model was used as a guiding framework. Principles of grounded theory, theoretical sampling, and constant comparison analysis were used to qualitatively analyze data generated from personal interviews of African-American parents (n = 30) and their 12- to 17-year-old daughters (n = 34). Read More
Br J Haematol 2018 Dec 12. Epub 2018 Dec 12.
Service d'Hématologie, Hôpital Pitié Salpêtrière APHP, Sorbonne Universités, Paris, France.
Jpn J Nurs Sci 2018 Dec 11. Epub 2018 Dec 11.
Section of Geriatric Dentistry, Department of General Dentistry, Fukuoka Dental College, Fukuoka, Japan.
Aim: To investigate nursing faculty members' perceptions of oral care and to identify the effects of an educational environment on their perceptions.
Methods: A cross-sectional questionnaire regarding oral care was conducted at eight nursing schools in Japan. A total of 156 (71. Read More
Acta Neurol Belg 2018 Dec 13. Epub 2018 Dec 13.
Geriatric Care Research Center, Rafsanjan University of Medical Science, Rafsanjan, Iran.
Parkinson's disease (PD) is one of the most common neuroinflammatory disorders and inflammatory processes seem to play an important role in the pathogenesis of PD. Chemokines as inflammatory mediators, which are involved in the recruitment of leukocytes, can play a role in the pathogenesis of PD. The aim of this study was to examine the serum level of eotaxins (CCL11, CCL24, and CCL26) and the expression of C-C chemokine receptor type 3 (CCR3) in patients with PD compared with healthy subjects. Read More
Esophagus 2018 Dec 13. Epub 2018 Dec 13.
AI Medical Service Inc., Tokyo, Japan.
Background And Aims: The endocytoscopic system (ECS) helps in virtual realization of histology and can aid in confirming histological diagnosis in vivo. We propose replacing biopsy-based histology for esophageal squamous cell carcinoma (ESCC) by using the ECS. We applied deep-learning artificial intelligence (AI) to analyse ECS images of the esophagus to determine whether AI can support endoscopists for the replacement of biopsy-based histology. Read More
AIDS Behav 2018 Dec 13. Epub 2018 Dec 13.
VA Puget Sound Health Care System, Health Services Research and Development, Seattle, WA, USA.
To quantify health care facility-level variation in pre-exposure prophylaxis (PrEP) use in the Veteran's Health Administration (VHA); to identify facility characteristics associated with PrEP use. Retrospective analysis of the health care facility-level rate of PrEP initiation in VHA through June 30, 2017. Standardized PrEP initiation rates were used to rank facilities. Read More
Geroscience 2018 Dec 13. Epub 2018 Dec 13.
Department of Animal, Dairy and Veterinary Sciences, Center for Integrated BioSystems, School of Veterinary Medicine, Utah State University, 4700 Old Main Hill, Logan, UT, 84322, USA.
Cardiovascular disease, rare in premenopausal women, increases sharply at menopause and is typically accompanied by chronic inflammation. Previous work in our laboratory demonstrated that replacing senescent ovaries in post-reproductive mice with young, actively cycling ovaries restored many health benefits, including decreased cardiomyopathy and restoration of immune function. Our objective here was to determine if depletion of germ cells from young transplanted ovaries would alter the ovarian-dependent extension of life and health span. Read More
Diabetologia 2018 Dec 13. Epub 2018 Dec 13.
Menzies Institute for Medical Research, University of Tasmania, 17 Liverpool Street, Private Bag 23, Hobart, TAS, 7000, Australia.
Aims/hypothesis: The aims of the study were to examine whether type 2 diabetes mellitus is associated with greater brain atrophy and cognitive decline, and whether brain atrophy mediates associations between type 2 diabetes and cognitive decline.
Methods: Participants without dementia aged 55-90 years from the Cognition and Diabetes in Older Tasmanians (CDOT) study underwent brain MRI (ventricular and total brain volume) and neuropsychological measures (global function and seven cognitive domains) at three time points over 4.6 years. Read More
Geriatr Orthop Surg Rehabil 2018 3;9:2151459318813976. Epub 2018 Dec 3.
Harborview Medical Center, Seattle, WA, USA.
Hip fractures result in significant morbidity and mortality in elders. Indicators of frailty are associated with poor outcomes. Commonly used frailty tools rely on motor skills that cannot be performed by this population. Read More