100,323 results match your criteria Geriatric Times[Journal]


Anticholinergic Burden and Dry Mouth in Middle-Aged People.

JDR Clin Trans Res 2019 Apr 23:2380084419844511. Epub 2019 Apr 23.

1 Periodontology and Geriatric Dentistry, Unit of Oral Health Sciences Research, University of Oulu, Oulu, Finland.

Introduction: Anticholinergic burden refers to the cumulative effect of taking 1 or more drugs with anticholinergic properties. At the moment, little is known about the association between the anticholinergic burden and dry mouth.

Objectives: The objective of this article was to study, whether an anticholinergic burden is associated with dry mouth among middle-aged people. Read More

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http://dx.doi.org/10.1177/2380084419844511DOI Listing

Putting the Measurement of Physical Capacity of Older Adults in Its Place.

Circulation 2019 Apr;139(17):2000-2002

Department of Internal Medicine, Section on Gerontology and Geriatric Medicine, Wake Forest School of Medicine, Winston-Salem, NC.

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http://dx.doi.org/10.1161/CIRCULATIONAHA.119.039116DOI Listing

Novel Therapies for an Aging Population: Grappling With Price, Value, and Affordability.

JAMA 2019 Apr;321(16):1567-1568

Institute for Clinical & Economic Review, Boston, Massachusetts.

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http://dx.doi.org/10.1001/jama.2019.2633DOI Listing

Effects of Interval Training on Visceral Adipose Tissue in Centrally Obese 70-Year-Old Individuals: A Randomized Controlled Trial.

J Am Geriatr Soc 2019 Apr 23. Epub 2019 Apr 23.

Department of Community Medicine and Rehabilitation, Geriatric Medicine, Umeå University, Umeå, Sweden.

Objective: To investigate the effects of 10 weeks of progressive vigorous-intensity interval training as a single intervention on body composition among 70-year-old individuals with central obesity.

Design: Randomized controlled trial (ClinicalTrials.gov registration No. Read More

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http://dx.doi.org/10.1111/jgs.15919DOI Listing

Altered large-scale functional brain networks in neurological Wilson's disease.

Brain Imaging Behav 2019 Apr 22. Epub 2019 Apr 22.

Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.

Wilson's disease patients with neurological symptoms have motor symptoms and cognitive deficits, including frontal executive, visuospatial processing, and memory impairments. Although the brain structural abnormalities associated with Wilson's disease have been documented, it remains largely unknown how Wilson's disease affects large-scale functional brain networks. In this study, we investigated functional brain networks in Wilson's disease. Read More

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http://dx.doi.org/10.1007/s11682-019-00066-yDOI Listing
April 2019
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Super-elderly patient-specific perioperative complications in breast cancer surgery.

Surg Today 2019 Apr 22. Epub 2019 Apr 22.

Department of Medical Oncology, Osaka City General Hospital, 2-13-22 Miyakojima-hondori, Miyakojima-ku, Osaka, 534-0021, Japan.

Purpose: Geriatric surgery poses specific challenges due to patient vulnerability in relation to aging. We analyzed perioperative challenges concerning super-elderly patients with breast cancer.

Methods: Between 2013 and 2018, 908 patients with breast cancer were treated surgically. Read More

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http://link.springer.com/10.1007/s00595-019-01812-x
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http://dx.doi.org/10.1007/s00595-019-01812-xDOI Listing
April 2019
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Effects of decompressive operation on cardiac autonomic regulation in patients with cervical spondylotic myelopathy: analysis of blood pressure, heart rate, and heart rate variability.

Eur Spine J 2019 Apr 22. Epub 2019 Apr 22.

Department of Orthopaedics, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450000, Henan Province, People's Republic of China.

Purpose: To investigate the effects of cervical decompression operation on cardiac autonomic regulation and its relationship to recovery of somatic neurological function in cervical spondylotic myelopathy (CSM) patients.

Methods: One hundred and thirty-two consecutive patients were enrolled in this study, in which 73 patients received decompression operation and the remaining 59 were treated non-operatively. The follow-up period was 6 months. Read More

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http://dx.doi.org/10.1007/s00586-019-05972-9DOI Listing

Differential effects of neurodegeneration biomarkers on subclinical cognitive decline.

Alzheimers Dement (N Y) 2019 12;5:129-138. Epub 2019 Apr 12.

Wisconsin Alzheimer's Disease Research Center, University of Wisconsin-Madison, Madison, WI, USA.

Introduction: Neurodegeneration appears to be the biological mechanism most proximate to cognitive decline in Alzheimer's disease. We test whether t-tau and alternative biomarkers of neurodegeneration-neurogranin and neurofilament light protein (NFL)-add value in predicting subclinical cognitive decline.

Methods: One hundred fifty cognitively unimpaired participants received a lumbar puncture for cerebrospinal fluid and at least two neuropsychological examinations (mean age at first visit = 59. Read More

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http://dx.doi.org/10.1016/j.trci.2019.02.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6462765PMC

White matter hyperintensities in vascular contributions to cognitive impairment and dementia (VCID): Knowledge gaps and opportunities.

Alzheimers Dement (N Y) 2019 9;5:107-117. Epub 2019 Apr 9.

Molecular & Clinical Sciences Research Institute, St George's University of London and Department of Neurology, St George's University Hospitals NHS Foundation Trust, London, UK.

White matter hyperintensities (WMHs) are frequently seen on brain magnetic resonance imaging scans of older people. Usually interpreted clinically as a surrogate for cerebral small vessel disease, WMHs are associated with increased likelihood of cognitive impairment and dementia (including Alzheimer's disease [AD]). WMHs are also seen in cognitively healthy people. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S23528737193000
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http://dx.doi.org/10.1016/j.trci.2019.02.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461571PMC
April 2019
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Recharacterization data for a geriatric gastrin polycolonal antibody.

Data Brief 2019 Jun 1;24:103886. Epub 2019 Apr 1.

Department of Cellular and Molecular Physiology, Institute of Translational Medicine, University of Liverpool, Crown St, Liverpool, L69 3BX, UK.

Radioimmunoassay data on the recharacterization of a gastrin polycolonal antibody first generated in 1973 is presented. The data include specificity, effect of matrix, and the establishment of a reference range for circulating fasting gastrin concentrations in normal subjects. For a discussion of the interpretation of the data, please see doi, 10. Read More

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http://dx.doi.org/10.1016/j.dib.2019.103886DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461591PMC

Antineoplastic therapy side effects and polypharmacy in older adults with cancer.

Top Geriatr Rehabil 2019 Jan-Mar;35(1):15-30

Oncology Consultants, Houston, Texas.

The geriatric oncology population requires special consideration in rehabilitation care planning due to drug side effects and potential drug interactions that occur with cancer treatment. Antineoplastic therapies incite side effects that are frequently managed with additional pharmacological interventions, often resulting in a cascade of drug side effects. Moreover, this population is disproportionately affected by multiple pre-existing co-morbidities that require the use of multiple medications. Read More

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http://dx.doi.org/10.1097/TGR.0000000000000212DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6474376PMC
January 2020

Continence Promotion and Successful Aging: The Role of the Multidisciplinary Continence Clinic.

Geriatrics (Basel) 2018 Dec 16;3(4). Epub 2018 Dec 16.

Division of Geriatric Medicine, Providence Health Care, Vancouver, BC, V6Z 1Y6, Canada.

Incontinence is a common yet under-recognized issue that impacts quality of life, especially for older adults in whom there is often a multifactorial etiology. A retrospective chart review was performed on a representative sample of patients seen at our multidisciplinary continence clinic in Vancouver, Canada from January to December 2017 inclusive. Initial assessment was performed by the nurse continence advisor (NCA) or geriatrician depending on the source of referral. Read More

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http://www.mdpi.com/2308-3417/3/4/91
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http://dx.doi.org/10.3390/geriatrics3040091DOI Listing
December 2018
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A New Strategic Approach to Successful Aging and Healthy Aging.

Authors:
Roger Y Wong

Geriatrics (Basel) 2018 Nov 29;3(4). Epub 2018 Nov 29.

Division of Geriatric Medicine, Department of Medicine, Faculty of Medicine, University of British Columbia, Vancouver, BC V5Z 1M9, Canada.

Successful aging is not a new concept, although its definition remains controversial, because of its multi-dimensional nature. [.. Read More

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http://www.mdpi.com/2308-3417/3/4/86
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http://dx.doi.org/10.3390/geriatrics3040086DOI Listing
November 2018
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Geriatrics Evaluation and Management in the Veterans Administration-An Historical Perspective.

Geriatrics (Basel) 2018 Nov 25;3(4). Epub 2018 Nov 25.

The San Francisco VA Medical Center, The University of California San Francisco School of Medicine, San Francisco, CA 94121, USA.

Comprehensive geriatric assessment, defined as an interdisciplinary assessment and development of an overall plan of treatment and follow-up, has become a fundamental part of clinical geriatric care. Since the 1970s, the US Department of Veterans Affairs (VA) has encouraged the development of geriatric evaluation and management programs. Evolution of geriatric evaluation and management has occurred over time and many VA medical centers have transferred inpatient geriatric evaluation programs to long-term care Community Living Centers, home, and outpatient settings. Read More

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http://www.mdpi.com/2308-3417/3/4/84
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http://dx.doi.org/10.3390/geriatrics3040084DOI Listing
November 2018
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An Analysis of Geriatric Medicine in Malaysia-Riding the Wave of Political Change.

Geriatrics (Basel) 2018 Nov 15;3(4). Epub 2018 Nov 15.

Ageing and Age-Associated Disorders Research Group, Faculty of Medicine, University of Malaya, Kuala Lumpur 50603, Malaysia.

Malaysia became the centre of international attention when it democratically removed a semi-authoritarian government of 62 years during its 14th general election this year. This electoral success has provided geriatric medicine in Malaysia with a high-impact ageing icon by installing the oldest prime minister in the world. A wave of optimism for the expansion of geriatric services in Malaysia, which met with numerous challenges in the last two decades, has emerged as a result of this political change. Read More

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http://dx.doi.org/10.3390/geriatrics3040080DOI Listing
November 2018

Successful Aging and Frailty: A Systematic Review.

Authors:
Darryl Rolfson

Geriatrics (Basel) 2018 Nov 15;3(4). Epub 2018 Nov 15.

Division of Geriatric Medicine, Department of Medicine, University of Alberta, Edmonton, AB T6G 2P4, Canada.

The terms successful aging (SA) and frailty appear to have much in common, both in terms of overlapping constructs and common challenges with consensus and operationalization. The aim of this review is to summarize existing literature that defines that relationship. Primary and secondary source articles that used either term in the title or abstract were systematically reviewed for relevance to the study objective. Read More

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http://dx.doi.org/10.3390/geriatrics3040079DOI Listing
November 2018

Falls in Geriatric Populations and Hydrotherapy as an Intervention: A Brief Review.

Geriatrics (Basel) 2018 Oct 18;3(4). Epub 2018 Oct 18.

Neuromechanics Laboratory, Mississippi State University, Mississippi State, MS 39762, USA.

Falls and fall-related injuries are a serious health concern in geriatric populations, especially with age-related deficits in postural control and during postural control challenging dual-task situations. Balance training has been reported to be beneficial in reducing falls. However, some of these exercises have their inherent physical challenges that prevent the elderly population from performing them effectively. Read More

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http://dx.doi.org/10.3390/geriatrics3040071DOI Listing
October 2018

Implementing Chief Resident Immersion Training (CRIT) in the Care of Older Adults: Overcoming Barriers and Promoting Facilitators.

Geriatrics (Basel) 2018 Sep 26;3(4). Epub 2018 Sep 26.

Division of General Internal Medicine, Palliative Medicine and Medical Education, Department of Internal Medicine, University of Louisville, 550 South Jackson St, 3rd Fl, Ste A3K00, Louisville, KY 40202, USA.

The Chief Resident Immersion Training (CRIT) in the Care of Older Adults curriculum was developed at Boston University School of Medicine to improve the care of older adults through an educational intervention. The curriculum targeted chief residents (CRs) because their role as mediators between learners and faculty provides the greatest potential impact for transmitting knowledge. The goals of CRIT are to: (1) provide education on geriatric principles and on teaching/leadership skills, (2) foster interdisciplinary collaboration, and (3) complete an action project. Read More

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http://dx.doi.org/10.3390/geriatrics3040062DOI Listing
September 2018

The Acute Care for Elders Unit Model of Care.

Authors:
Robert M Palmer

Geriatrics (Basel) 2018 Sep 11;3(3). Epub 2018 Sep 11.

Internal Medicine, Eastern Virginia Medical School 825 Fairfax Avenue, Suite 201 Norfolk, VA 23507, USA.

Older patients are at risk for loss of self-care abilities during the course of an acute medical illness that results in hospitalization. The Acute Care for Elders (ACE) Unit is a continuous quality improvement model of care designed to prevent the patient's loss of independence from admission to discharge in the performance of activities of daily living (hospital-associated disability). The ACE unit intervention includes principles of a prepared environment that encourages safe patient self-care, a set of clinical guidelines for bedside care by nurses and other health professionals to prevent patient disability and restore self-care lost by the acute illness, and planning for transitions of care and medical care. Read More

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http://dx.doi.org/10.3390/geriatrics3030059DOI Listing
September 2018

Strategies to Promote Broad-Based Implementation of Acute Care for Elders (ACE) Units.

Authors:
Roger Y Wong

Geriatrics (Basel) 2018 Sep 6;3(3). Epub 2018 Sep 6.

Division of Geriatric Medicine, Department of Medicine, Faculty of Medicine, University of British Columbia, Vancouver, BC V5Z 1M9, Canada.

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http://dx.doi.org/10.3390/geriatrics3030058DOI Listing
September 2018

Vet Connect: A Quality Improvement Program to Provide Telehealth Subspecialty Care for Veterans Residing in VA-Contracted Community Nursing Homes.

Geriatrics (Basel) 2018 Sep 5;3(3). Epub 2018 Sep 5.

VA Eastern Colorado Healthcare System Center of Innovation for Veteran-Centric and Value-Driven Care, 13611 East Colfax Ave., Aurora, CO 80045, USA.

Veterans residing in Veterans Health Administration (VA) contracted Community Nursing Homes (CNHs) receive primary care from the CNH they reside in, but often travel to Veterans Affairs Medical Centers (VAMCs) for specialty care services. The Vet Connect project is a quality improvement project aiming to implement video technology to support access to specialty care. : Eight Denver VAMC specialty care providers and three project nurses underwent telehealth training and obtained appropriate equipment. Read More

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http://dx.doi.org/10.3390/geriatrics3030057DOI Listing
September 2018

Orthogeriatrics and Hip Fracture Care in the UK: Factors Driving Change to More Integrated Models of Care.

Authors:
Mark Middleton

Geriatrics (Basel) 2018 Aug 28;3(3). Epub 2018 Aug 28.

Department of Trauma and Orthopaedics, St George's University Hospitals NHS Foundation Trust, Blackshaw Road, Tooting, London SW17 0QT, UK.

In the United Kingdom (UK), approximately 80,000 hip fractures each year result in an estimated annual cost of two billion pounds in direct healthcare costs alone. Various models of care exist for collaboration between orthopaedic surgeons and geriatricians in response to the complex medical, rehabilitation, and social needs of this patient group. Mounting evidence suggests that more integrated models of orthogeriatric care result in superior quality of care indicators and clinical outcomes. Read More

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http://dx.doi.org/10.3390/geriatrics3030055DOI Listing

Acute Care for Elders (ACE) Team Model of Care: A Clinical Overview.

Geriatrics (Basel) 2018 Aug 6;3(3). Epub 2018 Aug 6.

Division of Gerontology, Geriatrics, and Palliative Care, University of Alabama, Birmingham, AL 35294, USA.

The Institute of Medicine (IOM) Reports of and have called for more interprofessional and coordinated hospital care. For over 20 years, Acute Care for Elders (ACE) Units and models of care that disseminate ACE principles have demonstrated outcomes in-line with the IOM goals. The objective of this overview is to provide a concise summary of studies that describe outcomes of ACE models of care published in 1995 or later. Read More

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http://dx.doi.org/10.3390/geriatrics3030050DOI Listing

Use of Clinical Video Telehealth as a Tool for Optimizing Medications for Rural Older Veterans with Dementia.

Geriatrics (Basel) 2018 Jul 30;3(3). Epub 2018 Jul 30.

Division of Geriatrics, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA.

Community-Based Outpatient Clinics (CBOCs) allow delivery of primary care to rural veterans who are far from a main Veterans Affairs (VA) campus. However, CBOCs often do not have physicians with geriatric training. We used a clinical video telehealth (CVT) dementia service (Teledementia clinic) based in the Pittsburgh VA Healthcare System to optimize dementia patients' medications and potentially inappropriate medications (PIMs). Read More

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http://dx.doi.org/10.3390/geriatrics3030044DOI Listing

The Resurgence of Home-Based Primary Care Models in the United States.

Geriatrics (Basel) 2018 Jul 16;3(3). Epub 2018 Jul 16.

Home Centered Care Institute, Schaumburg, IL 60173, USA.

This article describes the forces behind the resurgence of home-based primary care (HBPC) in the United States and then details different HBPC models. Factors leading to the resurgence include an aging society, improved technology, an increased emphasis on home and community services, higher fee-for-service payments, and health care reform that rewards value over volume. The cost savings come principally from reduced institutional care in hospitals and skilled nursing facilities. Read More

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http://www.mdpi.com/2308-3417/3/3/41
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http://dx.doi.org/10.3390/geriatrics3030041DOI Listing
July 2018
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Frailty Screening and Case-Finding for Complex Chronic Conditions in Older Adults in Primary Care.

Geriatrics (Basel) 2018 Jul 7;3(3). Epub 2018 Jul 7.

Schlegel-University of Waterloo Research Institute for Aging, University of Waterloo, Waterloo, ON N2J 0E2, Canada.

With the aging population, escalating demand for seniors' care and limited specialist resources, new care delivery models are needed to improve capacity for primary health care for older adults. This paper describes the "C5-75" (Case-finding for Complex Chronic Conditions in Seniors 75+) program, an innovative care model aimed at identifying frailty and commonly associated geriatric conditions among older adults within a Canadian family practice setting and targeting interventions for identified conditions using a feasible, systematic, evidence-informed multi-disciplinary approach. We screen annually for frailty using gait speed and handgrip strength, screen for previously undiagnosed comorbid conditions, and offer frail older adults multi-faceted interventions that identify and address unrecognized medical and psychosocial needs. Read More

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http://dx.doi.org/10.3390/geriatrics3030039DOI Listing

A Stab in the Dark: A Case Report of an Atypical Presentation of Giant Cell Arteritis (GCA).

Geriatrics (Basel) 2018 Jun 29;3(3). Epub 2018 Jun 29.

Medicine for Older People, University Hospital Southampton, Southampton SO16 6YD, UK.

Giant cell arteritis/temporal arteritis (GCA) is an inflammatory condition that affects large to medium vessels such as the aorta and its primary branches. Patients classically present with fatigue, fever, headache, jaw claudication and in severe cases, may suffer either transient (amaurosis fugax) or permanent visual loss. The reference standard for diagnosis is the temporal artery biopsy (TAB) and the mainstay of treatment is with immunosuppression. Read More

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http://dx.doi.org/10.3390/geriatrics3030036DOI Listing

Optimising Clinical Trial Design in Older Cancer Patients.

Geriatrics (Basel) 2018 Jun 22;3(3). Epub 2018 Jun 22.

Discipline of Radiation Therapy, School of Medicine, Trinity College Dublin, Dublin, Ireland.

Cancer is predominantly a disease of older patients, with over half of those aged over 65 years of age being diagnosed with cancer at some stage. Despite comprising a significant proportion of the patients that we see in clinical practice, there is a lack of representation of older patients in cancer clinical trials. This is mainly due to restrictive trial inclusion criteria that prevent older patients from participating. Read More

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http://dx.doi.org/10.3390/geriatrics3030034DOI Listing

Prediction of Emergency Department Re-Visits in Older Patients by the Identification of Senior at Risk (ISAR) Screening.

Geriatrics (Basel) 2018 Jun 21;3(3). Epub 2018 Jun 21.

Emergency Department, University Hospital Zurich, Raemistrasse 100, 8091 Zurich, Switzerland.

The "Identification of Seniors at Risk" (ISAR) screening is a tool to identify seniors at risk of adverse outcomes. We investigated whether seniors with a positive ISAR screening have an increased risk of Emergency Department (ED) re-visits and health-service costs. In a pilot project, we enrolled 96 ED patients (≥70 years) who received an ISAR screening in the ED. Read More

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http://dx.doi.org/10.3390/geriatrics3030033DOI Listing

Reaching Out to Rural Caregivers and Veterans with Dementia Utilizing Clinical Video-Telehealth.

Geriatrics (Basel) 2018 Jun 9;3(2). Epub 2018 Jun 9.

The Tennessee Valley Healthcare System (JB) Nashville TN 37212, USA.

Context: A clinical video telehealth (CVT) program was implemented to improve access and quality of dementia care to patients and their caregivers in rural areas. The program was offered as part of an established dementia clinic/geriatric primary care clinic in collaboration with five community-based outpatient clinics (CBOC's) affiliated with the Tennessee Valley Healthcare System (TVHS) in middle Tennessee. Telehealth support was provided by a physician-social worker team visit. Read More

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http://www.mdpi.com/2308-3417/3/2/29
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http://dx.doi.org/10.3390/geriatrics3020029DOI Listing
June 2018
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Altered Functional Brain Connectivity in Mild Cognitive Impairment during a Cognitively Complex Car Following Task.

Geriatrics (Basel) 2018 Apr 19;3(2). Epub 2018 Apr 19.

Neuroscience Research Program, Keenan Research Centre for Biomedical Science, St. Michael's Hospital, Toronto, ON M5B 1T8, Canada.

Mild cognitive impairment (MCI) can affect multiple cognitive abilities, leading to difficulty in performing complex, cognitively demanding daily tasks, such as driving. This study combined driving simulation and functional magnetic resonance imaging (fMRI) to investigate brain function in individuals with MCI while they performed a car-following task. The behavioral driving performance of 24 patients with MCI and 20 healthy age-matched controls was compared during a simulated car-following task. Read More

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http://dx.doi.org/10.3390/geriatrics3020020DOI Listing

The Prevalence of Oropharyngeal Dysphagia in Acute Geriatric Patients.

Geriatrics (Basel) 2018 Mar 26;3(2). Epub 2018 Mar 26.

Department of Geriatric, North Denmark Hospital, DK-9800 Hjørring, Denmark.

Oropharyngeal dysphagia (OD) is underdiagnosed and undertreated in many geriatric centers. The aim of this study is to explore the prevalence of OD in acute geriatric patients. The outcome was mortality during hospitalization, mortality, and rehospitalization within 0⁻30 and 31⁻180 days of discharge. Read More

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http://dx.doi.org/10.3390/geriatrics3020015DOI Listing

One-Year Mortality Rates Before and After Implementing Quality-Improvement Initiatives to Prevent Inpatient Falls (2012⁻2016).

Geriatrics (Basel) 2018 Mar 5;3(1). Epub 2018 Mar 5.

Acute Medicine, Ysbyty Ystrad Fawr, Aneurin Bevan University Health Board, Ystrad Mynach, Wales CF82 7EP, UK.

Single-room ward design has previously been associated with increased risk of inpatient falls and adverse outcomes. However, following quality initiatives, the incidence of inpatient falls has shown a sustained reduction. Benefits have also been observed in the reduction of hip fractures. Read More

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http://dx.doi.org/10.3390/geriatrics3010009DOI Listing

High Prevalence of Diabetes in Patients With Primary Aldosteronism (PA) Associated With Subclinical Hypercortisolism and Prediabetes More Prevalent in Bilateral Than Unilateral PA: A Large, Multicenter Cohort Study in Japan.

Diabetes Care 2019 May;42(5):938-945

Department of Endocrinology and Metabolism, National Hospital Organization Kyoto Medical Center, Kyoto, Japan.

Objective: To investigate the prevalence and causes of diabetes in patients with primary aldosteronism (PA) in a multi-institutional cohort study in Japan.

Research Design And Methods: The prevalence of diabetes was determined in 2,210 patients with PA (diagnosed or glycated hemoglobin [HbA] ≥6.5% [≥48 mmol/mol]; NGSP) and compared with that of the Japanese general population according to age and sex. Read More

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http://dx.doi.org/10.2337/dc18-1293DOI Listing

The effect of aging on brain injury and recovery after stroke.

Neurobiol Dis 2019 Jun;126:1-2

Pittsburgh Institute of Brain Disorders & Recovery and Department of Neurology, University of Pittsburgh, Pittsburgh, PA 15213; Geriatric Research, Education and Clinical Center, Veterans Affairs Pittsburgh Health Care System, Pittsburgh, PA 15261.

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http://dx.doi.org/10.1016/j.nbd.2019.04.001DOI Listing

Hematology and Clinical Chemistry Reference Intervals for Inbred Strain 13/N Guinea Pigs (Cavia porcellus).

J Am Assoc Lab Anim Sci 2019 Apr 22. Epub 2019 Apr 22.

Inbred strain 13/N guinea pigs are frequently used as animal models in studies of emerging and high-pathogenicity viruses.To date, clinical reference intervals have not been established for hematology and clinical chemistry parameters in this strain.We obtained whole-blood samples from the cranial vena cava of healthy strain 13/N colony animals for inhouse CBC and clinical chemistry analyses. Read More

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http://dx.doi.org/10.30802/AALAS-JAALAS-18-000118DOI Listing

Correction to: Postoperative delirium in critically ill surgical patients: incidence, risk factors, and predictive scores.

BMC Anesthesiol 2019 Apr 22;19(1):58. Epub 2019 Apr 22.

Integrated Perioperative Geriatric Excellent Research Center, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand.

Following publication of the original article [1], the authors reported a missing data on Table 1 in their paper. The original article [1] has been updated. Read More

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http://dx.doi.org/10.1186/s12871-019-0732-8DOI Listing

Thirty-Day Readmission Risk Model for Older Adults Hospitalized With Acute Myocardial Infarction.

Circ Cardiovasc Qual Outcomes 2019 May;12(5):e005320

Leon H. Charney Division of Cardiology, Department of Medicine; Division of Healthcare Delivery Science, Department of Population Health, New York University School of Medicine (J.A.D.).

Background: Early readmissions among older adults hospitalized for acute myocardial infarction (AMI) are costly and difficult to predict. Aging-related functional impairments may inform risk prediction but are unavailable in most studies. Our objective was to, therefore, develop and validate an AMI readmission risk model for older patients who considered functional impairments and was suitable for use before hospital discharge. Read More

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https://www.ahajournals.org/doi/10.1161/CIRCOUTCOMES.118.005
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http://dx.doi.org/10.1161/CIRCOUTCOMES.118.005320DOI Listing
May 2019
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Temporal Trends of Percutaneous Coronary Interventions in Older Adults With Acute Myocardial Infarction.

Circ Cardiovasc Interv 2019 May;12(5):e007812

Sinai Hospital of Baltimore, LifeBridge Health Cardiovascular Institute, MD (M.M.).

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http://dx.doi.org/10.1161/CIRCINTERVENTIONS.119.007812DOI Listing

Improving reperfusion time within the ESCAPE Endovascular Clinical Trial.

Eur Stroke J 2017 Mar 30;2(1):64-69. Epub 2016 Nov 30.

Departments of Clinical Neurosciences, Medicine, Radiology and Community Health Sciences, Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Canada.

Introduction: Endovascular treatment of acute ischemic stroke is more effective when performed quickly. In this report, we describe quality interventions to ensure fast endovascular treatment times in the ESCAPE (Endovascular Treatment for Small Core and Anterior circulation Proximal Occlusion with Emphasis on Minimizing CT to Recanalization Times) trial.

Methods: An "audit and feedback" intervention using webinar and letter was used to improve treatment time over the course of the trial. Read More

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http://dx.doi.org/10.1177/2396987316681176DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6453179PMC

Clinical Decision-Making for Older Patients With Multiple Chronic Conditions: A Case-Based Exercise for Medical Students.

Authors:
Amy C Denham

MedEdPORTAL 2016 Sep 30;12:10477. Epub 2016 Sep 30.

Clinical Associate Professor, Department of Family Medicine, University of North Carolina at Chapel Hill School of Medicine.

Introduction: Over half of patients over age 65 in the US have multimorbidity, defined as having three or more chronic diseases, but most clinical research on chronic disease management focuses on single chronic diseases. An expert panel convened by the American Geriatrics Society has provided a framework of guiding principles for clinical decision-making in patients with multimorbidity. This resource describes a session for second-year medical students at the end of their preclinical curriculum, in which students practice using a framework for clinical decision-making for patients with multiple chronic diseases. Read More

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http://dx.doi.org/10.15766/mep_2374-8265.10477DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6464446PMC
September 2016

Breast Health Disparities: A Primer for Medical Students.

MedEdPORTAL 2016 Sep 28;12:10471. Epub 2016 Sep 28.

Associate Professor of Medicine, Department of Humanities, Health and Society, Florida International University Herbert Wertheim College of Medicine.

Introduction: While breast cancer incidence rates have remained stable and mortality rates have declined for white women, breast cancer mortality has steadily increased for African American women since the 1950s. It has often been assumed that genetic risks linked to African ancestry are the cause for these disparities. However, a better understanding of the role of stress and social and environmental factors in health lends evidence to the social determinants behind the increasing gaps in breast health outcomes. Read More

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http://dx.doi.org/10.15766/mep_2374-8265.10471DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6464433PMC
September 2016

Road Map for Opioid Management in the Inpatient Setting: A Structured Approach to Opioid Selection and Titration.

MedEdPORTAL 2016 Sep 28;12:10470. Epub 2016 Sep 28.

Assistant Dean of Faculty Development and Curriculum, Winthrop University Hospital Campus, Stony Brook University School of Medicine.

Introduction: Effective pain management is a major challenge of medicine as patients with acute and chronic pain conditions require careful evaluation and treatment. Despite required pain management education in postgraduate training, effective pain management is often not achieved in the hospital setting. For example, the Accreditation Council for Graduate Medical Education in 2007 required internal medicine residencies to include instruction on pain management. Read More

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http://dx.doi.org/10.15766/mep_2374-8265.10470DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6464480PMC
September 2016

Simulating Interprofessional Geriatric Patient Care Using Telehealth: A Team-Based Learning Activity.

MedEdPORTAL 2016 Jun 17;12:10415. Epub 2016 Jun 17.

Associate Professor, University of Oklahoma Health Sciences Center.

Introduction: More than one-third of Oklahomans live in rural counties, and 63 of Oklahoma's 77 counties are classified as health professional shortage areas, where telemedicine would be beneficial. In response to this need, in 2012, the Colleges of Nursing and Allied Health at the University of Oklahoma Health Sciences Center implemented a sequence of interprofessional learning experiences to prepare nurse practitioner, physical therapy, and occupational therapy students in team-based geriatric care using telehealth technologies.

Methods: The sequence included modules on interprofessional competencies, a simulated patient case, and clinical experiences. Read More

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http://dx.doi.org/10.15766/mep_2374-8265.10415DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6464453PMC

Advising Patients on How to Achieve Long-Term Weight Loss.

Ann Intern Med 2019 Apr 23. Epub 2019 Apr 23.

Baltimore VA Medical Center Geriatric Research Education and Clinical Center and University of Maryland School of Medicine, Baltimore, Maryland (L.I.K., J.D.S.).

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http://dx.doi.org/10.7326/M19-0782DOI Listing

Risk of deterioration of geriatric traumatic brain injury in patients treated with antithrombotic drugs.

World Neurosurg 2019 Apr 19. Epub 2019 Apr 19.

The Japan Neurotrauma Data Bank Committee, The Japan Society of Neurotraumatology, Tokyo, Japan.

Objective: Developed countries have rapidly aging populations, and use of antithrombotic drugs is increasing. We investigated the effects of antithrombotic drugs and reversal of these drugs in geriatric traumatic brain injury (TBI) patients.

Methods: Age, gender, mechanism of injury, Glasgow Coma Scale on admission, head CT findings, antithrombotic therapy, acute exacerbation, and outcomes at discharge were examined in 711 patients with geriatric TBI complicated with traumatic intracranial hemorrhage using data from the Japan Neurotrauma Data Bank Project 2015 (JNTDB P2015). Read More

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http://dx.doi.org/10.1016/j.wneu.2019.04.108DOI Listing

Dermal Calcium Loss is Not the Primary Determinant of PTH Secretion during Exercise.

Med Sci Sports Exerc 2019 Apr 18. Epub 2019 Apr 18.

Department of Medicine, Division of Geriatric Medicine, University of Colorado Denver, Aurora, CO.

Introduction: Exercise can cause a decrease in serum ionized calcium (iCa) concentration, which stimulates parathyroid hormone (PTH) secretion and activates bone resorption. We postulated that dermal Ca loss during cycling exercise is the major determinant of the serum iCa, PTH, and bone resorption (C-terminal telopeptide of type 1 collagen; CTX) responses.

Methods: To investigate this, women (n=13) and men (n=12) aged 18 to 45 years performed the same exercise bout under cool (18°C) and warm (26°C) conditions. Read More

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http://dx.doi.org/10.1249/MSS.0000000000002017DOI Listing
April 2019
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Chronic pain is associated with a brain aging biomarker in community-dwelling older adults.

Pain 2019 May;160(5):1119-1130

Department of Neuroimaging, Centre for Neuroimaging Sciences, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom.

Chronic pain is associated with brain atrophy with limited evidence on its impact in the older adult's brain. We aimed to determine the associations between chronic pain and a brain aging biomarker in persons aged 60 to 83 years old. Participants of the Neuromodulatory Examination of Pain and Mobility Across the Lifespan (NEPAL) study (N = 47) completed demographic, psychological, and pain assessments followed by a quantitative sensory testing battery and a T1-weighted magnetic resonance imaging. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001491DOI Listing

The need of developing selective prediction models in elderly patients with heart failure.

Int J Clin Pract 2019 Apr 22:e13354. Epub 2019 Apr 22.

IRCCS Ospedale Policlinico San Martino Genoa, 10 largo Benzi, 16132, Genoa, Italy.

It is with great interest that we have read the article by Özlek and co-workers, who performed a post-hoc analysis of results from the APOLLON trial (A comPrehensive, ObserationaL registry of heart faiLure with mid-range and preserved ejection fractiON). The authors investigated in a real-world study (patients included in a registry) the effects of treatment of octogenarian individuals with heart failure (HF) with mid-range and preserved ejection fraction, and then, the authors compared the observation in elderly to younger subjects. Interestingly, the authors reported that elderly patients with HF were similarly treated as compared to younger patients (in terms of ACE-Is/ARBs, β-blockers, MRAs, digoxin, ivabradine and diuretics), thus suggesting adherence to guideline recommendations independently of the age of subjects. Read More

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http://dx.doi.org/10.1111/ijcp.13354DOI Listing

Geriatric Oncology: Getting Even Better with Age.

J Am Geriatr Soc 2019 Apr 22. Epub 2019 Apr 22.

Division of Medical Oncology, Department of Medicine, Washington University School of Medicine, St Louis, Missouri.

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http://dx.doi.org/10.1111/jgs.15947DOI Listing